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2. Gene expression profiling of mucinous ovarian tumors and comparison with upper and lower gastrointestinal tumors identifies markers associated with adverse outcomes.

Author

Meagher, Nicola S, Gorringe, Kylie L, Wakefield, Matthew, Bolithon, Adelyn, Pang, Chi Nam Ignatius, Chiu, Derek S, Anglesio, Michael S, Mallitt, Kylie-Ann, Doherty, Jennifer A, Harris, Holly R, Schildkraut, Joellen M, Berchuck, Andrew, Cushing-Haugen, Kara L, Chezar, Ksenia, Chou, Angela, Tan, Adeline, Alsop, Jennifer, Barlow, Ellen, Beckmann, Matthias W, Boros, Jessica, Bowtell, David DL, Group, for the AOCS, Brand, Alison H, Brenton, James D, Campbell, Ian, Cheasley, Dane, Cohen, Joshua, Cybulski, Cezary, Elishaev, Esther, Erber, Ramona, Farrell, Rhonda, Fischer, Anna, Fu, Zhuxuan, Gilks, Blake, Gill, Anthony J, Initiative, for the Australian Pancreatic Genome, Gourley, Charlie, Grube, Marcel, Harnett, Paul R, Hartmann, Arndt, Hettiaratchi, Anusha, Høgdall, Claus K, Huzarski, Tomasz, Jakubowska, Anna, Jimenez-Linan, Mercedes, Kennedy, Catherine J, Kim, Byoung-Gie, Kim, Jae-Weon, Kim, Jae-Hoon, Klett, Kayla, Koziak, Jennifer M, Lai, Tiffany, Laslavic, Angela, Lester, Jenny, Leung, Yee, Li, Na, Liauw, Winston, Lim, Belle WX, Linder, Anna, Lubiński, Jan, Mahale, Sakshi, Mateoiu, Constantina, McInerny, Simone, Menkiszak, Janusz, Minoo, Parham, Mittelstadt, Suzana, Morris, David, Orsulic, Sandra, Park, Sang-Yoon, Pearce, Celeste Leigh, Pearson, John V, Pike, Malcolm C, Quinn, Carmel M, Mohan, Ganendra Raj, Rao, Jianyu, Riggan, Marjorie J, Ruebner, Matthias, Salfinger, Stuart, Scott, Clare L, Shah, Mitul, Steed, Helen, Stewart, Colin JR, Subramanian, Deepak, Sung, Soseul, Tang, Katrina, Timpson, Paul, Ward, Robyn L, Wiedenhoefer, Rebekka, Thorne, Heather, Investigators, for the kConFab, Cohen, Paul A, Crowe, Philip, Fasching, Peter A, Gronwald, Jacek, Hawkins, Nicholas J, Høgdall, Estrid, Huntsman, David G, James, Paul A, Karlan, Beth Y, and Kelemen, Linda E

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Ovarian Cancer, Rare Diseases, Cancer, Digestive Diseases, Genetics, 4.1 Discovery and preclinical testing of markers and technologies, Detection, screening and diagnosis, Female, Humans, Neoplasm Staging, Ovarian Neoplasms, Carcinoma, Ovarian Epithelial, Adenocarcinoma, Mucinous, Prognosis, Gastrointestinal Neoplasms, AOCS Group, Australian Pancreatic Genome Initiative, kConFab Investigators, Oncology & Carcinogenesis, Clinical sciences, Oncology and carcinogenesis
Abstract

PurposeAdvanced-stage mucinous ovarian carcinoma (MOC) has poor chemotherapy response and prognosis and lacks biomarkers to aid stage I adjuvant treatment. Differentiating primary MOC from gastrointestinal (GI) metastases to the ovary is also challenging due to phenotypic similarities. Clinicopathologic and gene-expression data were analyzed to identify prognostic and diagnostic features.Experimental designDiscovery analyses selected 19 genes with prognostic/diagnostic potential. Validation was performed through the Ovarian Tumor Tissue Analysis consortium and GI cancer biobanks comprising 604 patients with MOC (n = 333), mucinous borderline ovarian tumors (MBOT, n = 151), and upper GI (n = 65) and lower GI tumors (n = 55).ResultsInfiltrative pattern of invasion was associated with decreased overall survival (OS) within 2 years from diagnosis, compared with expansile pattern in stage I MOC [hazard ratio (HR), 2.77; 95% confidence interval (CI), 1.04-7.41, P = 0.042]. Increased expression of THBS2 and TAGLN was associated with shorter OS in MOC patients (HR, 1.25; 95% CI, 1.04-1.51, P = 0.016) and (HR, 1.21; 95% CI, 1.01-1.45, P = 0.043), respectively. ERBB2 (HER2) amplification or high mRNA expression was evident in 64 of 243 (26%) of MOCs, but only 8 of 243 (3%) were also infiltrative (4/39, 10%) or stage III/IV (4/31, 13%).ConclusionsAn infiltrative growth pattern infers poor prognosis within 2 years from diagnosis and may help select stage I patients for adjuvant therapy. High expression of THBS2 and TAGLN in MOC confers an adverse prognosis and is upregulated in the infiltrative subtype, which warrants further investigation. Anti-HER2 therapy should be investigated in a subset of patients. MOC samples clustered with upper GI, yet markers to differentiate these entities remain elusive, suggesting similar underlying biology and shared treatment strategies.

Published
2022

3. A first-in-class pan-lysyl oxidase inhibitor impairs stromal remodeling and enhances gemcitabine response and survival in pancreatic cancer

Author

Chitty, Jessica L., Yam, Michelle, Perryman, Lara, Parker, Amelia L., Skhinas, Joanna N., Setargew, Yordanos F. I., Mok, Ellie T. Y., Tran, Emmi, Grant, Rhiannon D., Latham, Sharissa L., Pereira, Brooke A., Ritchie, Shona C., Murphy, Kendelle J., Trpceski, Michael, Findlay, Alison D., Melenec, Pauline, Filipe, Elysse C., Nadalini, Audrey, Velayuthar, Sipiththa, Major, Gretel, Wyllie, Kaitlin, Papanicolaou, Michael, Ratnaseelan, Shivanjali, Phillips, Phoebe A., Sharbeen, George, Youkhana, Janet, Russo, Alice, Blackwell, Antonia, Hastings, Jordan F., Lucas, Morghan C., Chambers, Cecilia R., Reed, Daniel A., Stoehr, Janett, Vennin, Claire, Pidsley, Ruth, Zaratzian, Anaiis, Da Silva, Andrew M., Tayao, Michael, Charlton, Brett, Herrmann, David, Nobis, Max, Clark, Susan J., Biankin, Andrew V., Johns, Amber L., Croucher, David R., Nagrial, Adnan, Gill, Anthony J., Grimmond, Sean M., Pajic, Marina, Timpson, Paul, Jarolimek, Wolfgang, and Cox, Thomas R.

Published
2023
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4. Temporal profiling of the breast tumour microenvironment reveals collagen XII as a driver of metastasis

Author

Papanicolaou, Michael, Parker, Amelia L., Yam, Michelle, Filipe, Elysse C., Wu, Sunny Z., Chitty, Jessica L., Wyllie, Kaitlin, Tran, Emmi, Mok, Ellie, Nadalini, Audrey, Skhinas, Joanna N., Lucas, Morghan C., Herrmann, David, Nobis, Max, Pereira, Brooke A., Law, Andrew M. K., Castillo, Lesley, Murphy, Kendelle J., Zaratzian, Anaiis, Hastings, Jordan F., Croucher, David R., Lim, Elgene, Oliver, Brian G., Mora, Fatima Valdes, Parker, Benjamin L., Gallego-Ortega, David, Swarbrick, Alexander, O’Toole, Sandra, Timpson, Paul, and Cox, Thomas R.

Published
2022
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5. Multiphoton intravital microscopy of rodents

Author

Scheele, Colinda L. G. J., Herrmann, David, Yamashita, Erika, Lo Celso, Cristina, Jenne, Craig N., Oktay, Maja H., Entenberg, David, Friedl, Peter, Weigert, Roberto, Meijboom, Franck L. B., Ishii, Masaru, Timpson, Paul, and van Rheenen, Jacco

Published
2022
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8. Tumor Biomechanics Alters Metastatic Dissemination of Triple Negative Breast Cancer via Rewiring Fatty Acid Metabolism

Author

Filipe, Elysse C., primary, Velayuthar, Sipiththa, additional, Philp, Ashleigh, additional, Nobis, Max, additional, Latham, Sharissa L., additional, Parker, Amelia L., additional, Murphy, Kendelle J., additional, Wyllie, Kaitlin, additional, Major, Gretel S., additional, Contreras, Osvaldo, additional, Mok, Ellie T. Y., additional, Enriquez, Ronaldo F., additional, McGowan, Suzanne, additional, Feher, Kristen, additional, Quek, Lake‐Ee, additional, Hancock, Sarah E., additional, Yam, Michelle, additional, Tran, Emmi, additional, Setargew, Yordanos F. I., additional, Skhinas, Joanna N., additional, Chitty, Jessica L., additional, Phimmachanh, Monica, additional, Han, Jeremy Z. R., additional, Cadell, Antonia L., additional, Papanicolaou, Michael, additional, Mahmodi, Hadi, additional, Kiedik, Beata, additional, Junankar, Simon, additional, Ross, Samuel E., additional, Lam, Natasha, additional, Coulson, Rhiannon, additional, Yang, Jessica, additional, Zaratzian, Anaiis, additional, Da Silva, Andrew M., additional, Tayao, Michael, additional, Chin, Ian L., additional, Cazet, Aurélie, additional, Kansara, Maya, additional, Segara, Davendra, additional, Parker, Andrew, additional, Hoy, Andrew J., additional, Harvey, Richard P., additional, Bogdanovic, Ozren, additional, Timpson, Paul, additional, Croucher, David R., additional, Lim, Elgene, additional, Swarbrick, Alexander, additional, Holst, Jeff, additional, Turner, Nigel, additional, Choi, Yu Suk, additional, Kabakova, Irina V., additional, Philp, Andrew, additional, and Cox, Thomas R., additional

Published
2024
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11. Compression-dependent microtubule reinforcement enables cells to navigate confined environments

Author

Ju, Robert J., Falconer, Alistair D., Schmidt, Christanny J., Enriquez Martinez, Marco A., Dean, Kevin M., Fiolka, Reto P., Sester, David P., Nobis, Max, Timpson, Paul, Lomakin, Alexis J., Danuser, Gaudenz, White, Melanie D., Haass, Nikolas K., Oelz, Dietmar B., and Stehbens, Samantha J.

Abstract

Cells migrating through complex three-dimensional environments experience considerable physical challenges, including tensile stress and compression. To move, cells need to resist these forces while also squeezing the large nucleus through confined spaces. This requires highly coordinated cortical contractility. Microtubules can both resist compressive forces and sequester key actomyosin regulators to ensure appropriate activation of contractile forces. Yet, how these two roles are integrated to achieve nuclear transmigration in three dimensions is largely unknown. Here, we demonstrate that compression triggers reinforcement of a dedicated microtubule structure at the rear of the nucleus by the mechanoresponsive recruitment of cytoplasmic linker-associated proteins, which dynamically strengthens and repairs the lattice. These reinforced microtubules form the mechanostat: an adaptive feedback mechanism that allows the cell to both withstand compressive force and spatiotemporally organize contractility signalling pathways. The microtubule mechanostat facilitates nuclear positioning and coordinates force production to enable the cell to pass through constrictions. Disruption of the mechanostat imbalances cortical contractility, stalling migration and ultimately resulting in catastrophic cell rupture. Our findings reveal a role for microtubules as cellular sensors that detect and respond to compressive forces, enabling movement and ensuring survival in mechanically demanding environments.

Published
2024
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15. Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis

Author

Samuel, Monisha, Fonseka, Pamali, Sanwlani, Rahul, Gangoda, Lahiru, Chee, Sing Ho, Keerthikumar, Shivakumar, Spurling, Alex, Chitti, Sai V., Zanker, Damien, Ang, Ching-Seng, Atukorala, Ishara, Kang, Taeyoung, Shahi, Sanjay, Marzan, Akbar L., Nedeva, Christina, Vennin, Claire, Lucas, Morghan C., Cheng, Lesley, Herrmann, David, Pathan, Mohashin, Chisanga, David, Warren, Sean C., Zhao, Kening, Abraham, Nidhi, Anand, Sushma, Boukouris, Stephanie, Adda, Christopher G., Jiang, Lanzhou, Shekhar, Tanmay M., Baschuk, Nikola, Hawkins, Christine J., Johnston, Amelia J., Orian, Jacqueline Monique, Hoogenraad, Nicholas J., Poon, Ivan K., Hill, Andrew F., Jois, Markandeya, Timpson, Paul, Parker, Belinda S., and Mathivanan, Suresh

Published
2021
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18. Ex vivo culture of intact human patient derived pancreatic tumour tissue

Author

Kokkinos, John, Sharbeen, George, Haghighi, Koroush S., Ignacio, Rosa Mistica C., Kopecky, Chantal, Gonzales-Aloy, Estrella, Youkhana, Janet, Timpson, Paul, Pereira, Brooke A., Ritchie, Shona, Pandzic, Elvis, Boyer, Cyrille, Davis, Thomas P., Butler, Lisa M., Goldstein, David, McCarroll, Joshua A., and Phillips, Phoebe A.

Published
2021
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20. ROCK-mediated selective activation of PERK signalling causes fibroblast reprogramming and tumour progression through a CRELD2-dependent mechanism

Author

Boyle, Sarah Theresa, Poltavets, Valentina, Kular, Jasreen, Pyne, Natasha Theresa, Sandow, Jarrod John, Lewis, Alexander Charles, Murphy, Kendelle Joan, Kolesnikoff, Natasha, Moretti, Paul Andre Bartholomew, Tea, Melinda Nay, Tergaonkar, Vinay, Timpson, Paul, Pitson, Stuart Maxwell, Webb, Andrew Ian, Whitfield, Robert John, Lopez, Angel Francisco, Kochetkova, Marina, and Samuel, Michael Susithiran

Published
2020
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22. Fibroblast growth factor-induced lens fiber cell elongation is driven by the stepwise activity of Rho and Rac.

Author

Yuki Sugiyama, Reed, Daniel A., Herrmann, David, Lovicu, Frank J., Robinson, Michael L., Timpson, Paul, and Masai, Ichiro

Subjects
FIBROBLAST growth factors, FIBROBLASTS, CRYSTALLINE lens, FIBERS
Abstract

The spheroidal shape of the eye lens is crucial for precise light focusing onto the retina. This shape is determined by concentrically aligned, convexly elongated lens fiber cells along the anterior and posterior axis of the lens. Upon differentiation at the lens equator, the fiber cells increase in height as their apical and basal tips migrate towards the anterior and posterior poles, respectively. The forces driving this elongation and migration remain unclear. We found that, in the mouse lens, membrane protrusions or lamellipodia are observed only in the maturing fibers undergoing cell curve conversion, indicating that lamellipodium formation is not the primary driver of earlier fiber migration. We demonstrated that elevated levels of fibroblast growth factor (FGF) suppressed the extension of Racdependent protrusions, suggesting changes in the activity of FGF controlling Rac activity, switching to lamellipodium-driven migration. Inhibitors of ROCK, myosin and actin reduced the height of both early and later fibers, indicating that elongation of these fibers relies on actomyosin contractility. Consistent with this, active RhoA was detected throughout these fibers. Given that FGF promotes fiber elongation, we propose that it does so through regulation of Rho activity. [ABSTRACT FROM AUTHOR]

Published
2024
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23. BCRP drives intrinsic chemoresistance in chemotherapy-naïve breast cancer brain metastasis

Author

Uceda-Castro, Rebeca, primary, Margarido, Andreia S., additional, Song, Ji-Ying, additional, de Gooijer, Mark C., additional, Messal, Hendrik A., additional, Chambers, Cecilia R., additional, Nobis, Max, additional, Çitirikkaya, Ceren H., additional, Hahn, Kerstin, additional, Seinstra, Danielle, additional, Herrmann, David, additional, Timpson, Paul, additional, Wesseling, Pieter, additional, van Tellingen, Olaf, additional, Vennin, Claire, additional, and van Rheenen, Jacco, additional

Published
2023
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24. Therapeutic blockade of ER stress and inflammation prevents NASH and progression to HCC

Author

Boslem, Ebru, primary, Reibe, Saskia, additional, Carlessi, Rodrigo, additional, Smeuninx, Benoit, additional, Tegegne, Surafel, additional, Egan, Casey L., additional, McLennan, Emma, additional, Terry, Lauren V., additional, Nobis, Max, additional, Mu, Andre, additional, Nowell, Cameron, additional, Horadagoda, Neil, additional, Henstridge, Darren C., additional, Mellett, Natalie A., additional, Timpson, Paul, additional, Jones, Matthew, additional, Denisenko, Elena, additional, Forrest, Alistair R. R., additional, Tirnitz-Parker, Janina E. E., additional, Meikle, Peter J., additional, Rose-John, Stefan, additional, Karin, Michael, additional, and Febbraio, Mark A., additional

Published
2023
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25. Evidence that TLR4 Is Not a Receptor for Saturated Fatty Acids but Mediates Lipid-Induced Inflammation by Reprogramming Macrophage Metabolism

Author

Lancaster, Graeme I., Langley, Katherine G., Berglund, Nils Anton, Kammoun, Helene L., Reibe, Saskia, Estevez, Emma, Weir, Jacquelyn, Mellett, Natalie A., Pernes, Gerard, Conway, James R.W., Lee, Man K.S., Timpson, Paul, Murphy, Andrew J., Masters, Seth L., Gerondakis, Steve, Bartonicek, Nenad, Kaczorowski, Dominik C., Dinger, Marcel E., Meikle, Peter J., Bond, Peter J., and Febbraio, Mark A.

Published
2018
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28. A study examining the role of Rho family GTPases in the intracellular targeting of Src kinase during cell polarisation and migration

Author

Timpson, Paul

Subjects
572, Cellular adhesion
Abstract

The ability of a cell to polarise and move is governed by re-modelling of the cellular adhesion/cytoskeletal network that is in turn controlled by the Rho family of small GTPases. However, it is not known what signals lie downstream of Rad and Cdc42 during peripheral adhesion re-modelling that are required for directional migration. We show here that individual members of the Rho family, RhoA, Rac1 and Cdc42, direct the specific intracellular targeting of c-Src tyrosine kinase to focal adhesions, lamellipodia or filopodia, respectively, and that the adaptor function of c-Src (the combined SH3/SH2 domains coupled to green fluorescent protein) is sufficient for targeting. Furthermore, Src's catalytic activity is absolutely required at these peripheral cell-matrix attachment sites for adhesion re-modelling that converts RhoA-dependent focal adhesions into smaller focal complexes along Rad-induced lamellipodia or Cdc42-induced filopodia. Consequently, cells in which kinase-deficient c-Src occupies peripheral adhesion sites exhibit impaired polarisation towards migratory stimuli and reduced motility. Our findings demonstrate that individual Rho GTPases specify Src's exact peripheral localisation, and that RhoA, Rac1 and Cdc42 cannot co-ordinate cell structural changes and directed cell migration when Src is present at adhesion sites in an inactive form. Src's role, which involves phosphorylation of adhesion substrates including FAK, is to induce the necessary adhesion re-modelling downstream of Rac1 and Cdc42 during migratory cell responses.

Published
2002

29. MASTL overexpression promotes chromosome instability and metastasis in breast cancer

Author

Rogers, Samuel, McCloy, Rachael A., Parker, Benjamin L., Gallego-Ortega, David, Law, Andrew M. K., Chin, Venessa T., Conway, James R. W., Fey, Dirk, Millar, Ewan K. A., O’Toole, Sandra, Deng, Niantao, Swarbrick, Alexander, Chastain, Paul D., Cesare, Anthony J., Timpson, Paul, Caldon, C. Elizabeth, Croucher, David R., James, David E., Watkins, D. Neil, and Burgess, Andrew

Published
2018
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30. Monitoring AKT activity and targeting in live tissue and disease contexts using a real-time Akt-FRET biosensor mouse

Author

Conway, James R. W., primary, Warren, Sean C., additional, Lee, Young-Kyung, additional, McCulloch, Andrew T., additional, Magenau, Astrid, additional, Lee, Victoria, additional, Metcalf, Xanthe L., additional, Stoehr, Janett, additional, Haigh, Katharina, additional, Abdulkhalek, Lea, additional, Guaman, Cristian S., additional, Reed, Daniel A., additional, Murphy, Kendelle J., additional, Pereira, Brooke A., additional, Mélénec, Pauline, additional, Chambers, Cecilia, additional, Latham, Sharissa L., additional, Lenthall, Helen, additional, Deenick, Elissa K., additional, Ma, Yuanqing, additional, Phan, Tri, additional, Lim, Elgene, additional, Joshua, Anthony M., additional, Walters, Stacey, additional, Grey, Shane T., additional, Shi, Yan-Chuan, additional, Zhang, Lei, additional, Herzog, Herbert, additional, Croucher, David R., additional, Philp, Andy, additional, Scheele, Colinda L.G.J., additional, Herrmann, David, additional, Sansom, Owen J., additional, Morton, Jennifer P., additional, Papa, Antonella, additional, Haigh, Jody J., additional, Nobis, Max, additional, and Timpson, Paul, additional

Published
2023
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31. Data from Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition

Author

Sharbeen, George, primary, McCarroll, Joshua A., primary, Akerman, Anouschka, primary, Kopecky, Chantal, primary, Youkhana, Janet, primary, Kokkinos, John, primary, Holst, Jeff, primary, Boyer, Cyrille, primary, Erkan, Mert, primary, Goldstein, David, primary, Timpson, Paul, primary, Cox, Thomas R., primary, Pereira, Brooke A., primary, Chitty, Jessica L., primary, Fey, Sigrid K., primary, Najumudeen, Arafath K., primary, Campbell, Andrew D., primary, Sansom, Owen J., primary, Ignacio, Rosa Mistica C., primary, Naim, Stephanie, primary, Liu, Jie, primary, Russia, Nelson, primary, Lee, Julia, primary, Chou, Angela, primary, Johns, Amber, primary, Gill, Anthony J., primary, Gonzales-Aloy, Estrella, primary, Gebski, Val, primary, Guan, Yi Fang, primary, Pajic, Marina, primary, Turner, Nigel, primary, Apte, Minoti V., primary, Davis, Thomas P., primary, Morton, Jennifer P., primary, Haghighi, Koroush S., primary, Kasparian, Jorjina, primary, McLean, Benjamin J., primary, Setargew, Yordanos F., primary, and Phillips, Phoebe A., primary

Published
2023
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32. Data from Rho Kinase Inhibition by AT13148 Blocks Pancreatic Ductal Adenocarcinoma Invasion and Tumor Growth

Author

Rath, Nicola, primary, Munro, June, primary, Cutiongco, Marie Francene, primary, Jagiełło, Alicja, primary, Gadegaard, Nikolaj, primary, McGarry, Lynn, primary, Unbekandt, Mathieu, primary, Michalopoulou, Evdokia, primary, Kamphorst, Jurre J., primary, Sumpton, David, primary, Mackay, Gillian, primary, Vennin, Claire, primary, Pajic, Marina, primary, Timpson, Paul, primary, and Olson, Michael F., primary

Published
2023
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33. Supplemental Figures S1 to S5 from Rho Kinase Inhibition by AT13148 Blocks Pancreatic Ductal Adenocarcinoma Invasion and Tumor Growth

Author

Rath, Nicola, primary, Munro, June, primary, Cutiongco, Marie Francene, primary, Jagiełło, Alicja, primary, Gadegaard, Nikolaj, primary, McGarry, Lynn, primary, Unbekandt, Mathieu, primary, Michalopoulou, Evdokia, primary, Kamphorst, Jurre J., primary, Sumpton, David, primary, Mackay, Gillian, primary, Vennin, Claire, primary, Pajic, Marina, primary, Timpson, Paul, primary, and Olson, Michael F., primary

Published
2023
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34. Figure S2 from Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition

Author

Sharbeen, George, primary, McCarroll, Joshua A., primary, Akerman, Anouschka, primary, Kopecky, Chantal, primary, Youkhana, Janet, primary, Kokkinos, John, primary, Holst, Jeff, primary, Boyer, Cyrille, primary, Erkan, Mert, primary, Goldstein, David, primary, Timpson, Paul, primary, Cox, Thomas R., primary, Pereira, Brooke A., primary, Chitty, Jessica L., primary, Fey, Sigrid K., primary, Najumudeen, Arafath K., primary, Campbell, Andrew D., primary, Sansom, Owen J., primary, Ignacio, Rosa Mistica C., primary, Naim, Stephanie, primary, Liu, Jie, primary, Russia, Nelson, primary, Lee, Julia, primary, Chou, Angela, primary, Johns, Amber, primary, Gill, Anthony J., primary, Gonzales-Aloy, Estrella, primary, Gebski, Val, primary, Guan, Yi Fang, primary, Pajic, Marina, primary, Turner, Nigel, primary, Apte, Minoti V., primary, Davis, Thomas P., primary, Morton, Jennifer P., primary, Haghighi, Koroush S., primary, Kasparian, Jorjina, primary, McLean, Benjamin J., primary, Setargew, Yordanos F., primary, and Phillips, Phoebe A., primary

Published
2023
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35. Supplementary Table 2 from Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition

Author

Sharbeen, George, primary, McCarroll, Joshua A., primary, Akerman, Anouschka, primary, Kopecky, Chantal, primary, Youkhana, Janet, primary, Kokkinos, John, primary, Holst, Jeff, primary, Boyer, Cyrille, primary, Erkan, Mert, primary, Goldstein, David, primary, Timpson, Paul, primary, Cox, Thomas R., primary, Pereira, Brooke A., primary, Chitty, Jessica L., primary, Fey, Sigrid K., primary, Najumudeen, Arafath K., primary, Campbell, Andrew D., primary, Sansom, Owen J., primary, Ignacio, Rosa Mistica C., primary, Naim, Stephanie, primary, Liu, Jie, primary, Russia, Nelson, primary, Lee, Julia, primary, Chou, Angela, primary, Johns, Amber, primary, Gill, Anthony J., primary, Gonzales-Aloy, Estrella, primary, Gebski, Val, primary, Guan, Yi Fang, primary, Pajic, Marina, primary, Turner, Nigel, primary, Apte, Minoti V., primary, Davis, Thomas P., primary, Morton, Jennifer P., primary, Haghighi, Koroush S., primary, Kasparian, Jorjina, primary, McLean, Benjamin J., primary, Setargew, Yordanos F., primary, and Phillips, Phoebe A., primary

Published
2023
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36. Supplementary Table 4 from Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition

Author

Sharbeen, George, primary, McCarroll, Joshua A., primary, Akerman, Anouschka, primary, Kopecky, Chantal, primary, Youkhana, Janet, primary, Kokkinos, John, primary, Holst, Jeff, primary, Boyer, Cyrille, primary, Erkan, Mert, primary, Goldstein, David, primary, Timpson, Paul, primary, Cox, Thomas R., primary, Pereira, Brooke A., primary, Chitty, Jessica L., primary, Fey, Sigrid K., primary, Najumudeen, Arafath K., primary, Campbell, Andrew D., primary, Sansom, Owen J., primary, Ignacio, Rosa Mistica C., primary, Naim, Stephanie, primary, Liu, Jie, primary, Russia, Nelson, primary, Lee, Julia, primary, Chou, Angela, primary, Johns, Amber, primary, Gill, Anthony J., primary, Gonzales-Aloy, Estrella, primary, Gebski, Val, primary, Guan, Yi Fang, primary, Pajic, Marina, primary, Turner, Nigel, primary, Apte, Minoti V., primary, Davis, Thomas P., primary, Morton, Jennifer P., primary, Haghighi, Koroush S., primary, Kasparian, Jorjina, primary, McLean, Benjamin J., primary, Setargew, Yordanos F., primary, and Phillips, Phoebe A., primary

Published
2023
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37. Data from Intravital FLIM-FRET Imaging Reveals Dasatinib-Induced Spatial Control of Src in Pancreatic Cancer

Author

Nobis, Max, primary, McGhee, Ewan J., primary, Morton, Jennifer P., primary, Schwarz, Juliane P., primary, Karim, Saadia A., primary, Quinn, Jean, primary, Edward, Mike, primary, Campbell, Andrew D., primary, McGarry, Lynn C., primary, Evans, T.R. Jeffry, primary, Brunton, Valerie G., primary, Frame, Margaret C., primary, Carragher, Neil O., primary, Wang, Yingxiao, primary, Sansom, Owen J., primary, Timpson, Paul, primary, and Anderson, Kurt I., primary

Published
2023
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38. Supplementary Movie 5 from Intravital FLIM-FRET Imaging Reveals Dasatinib-Induced Spatial Control of Src in Pancreatic Cancer

Author

Nobis, Max, primary, McGhee, Ewan J., primary, Morton, Jennifer P., primary, Schwarz, Juliane P., primary, Karim, Saadia A., primary, Quinn, Jean, primary, Edward, Mike, primary, Campbell, Andrew D., primary, McGarry, Lynn C., primary, Evans, T.R. Jeffry, primary, Brunton, Valerie G., primary, Frame, Margaret C., primary, Carragher, Neil O., primary, Wang, Yingxiao, primary, Sansom, Owen J., primary, Timpson, Paul, primary, and Anderson, Kurt I., primary

Published
2023
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39. Supplementary Movie 4 from Intravital FLIM-FRET Imaging Reveals Dasatinib-Induced Spatial Control of Src in Pancreatic Cancer

Author

Nobis, Max, primary, McGhee, Ewan J., primary, Morton, Jennifer P., primary, Schwarz, Juliane P., primary, Karim, Saadia A., primary, Quinn, Jean, primary, Edward, Mike, primary, Campbell, Andrew D., primary, McGarry, Lynn C., primary, Evans, T.R. Jeffry, primary, Brunton, Valerie G., primary, Frame, Margaret C., primary, Carragher, Neil O., primary, Wang, Yingxiao, primary, Sansom, Owen J., primary, Timpson, Paul, primary, and Anderson, Kurt I., primary

Published
2023
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41. Supplementary Figure S2 from Intravital FLIM-FRET Imaging Reveals Dasatinib-Induced Spatial Control of Src in Pancreatic Cancer

Author

Nobis, Max, primary, McGhee, Ewan J., primary, Morton, Jennifer P., primary, Schwarz, Juliane P., primary, Karim, Saadia A., primary, Quinn, Jean, primary, Edward, Mike, primary, Campbell, Andrew D., primary, McGarry, Lynn C., primary, Evans, T.R. Jeffry, primary, Brunton, Valerie G., primary, Frame, Margaret C., primary, Carragher, Neil O., primary, Wang, Yingxiao, primary, Sansom, Owen J., primary, Timpson, Paul, primary, and Anderson, Kurt I., primary

Published
2023
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43. Supplementary Movie 4 from Spatial Regulation of RhoA Activity during Pancreatic Cancer Cell Invasion Driven by Mutant p53

Author

Timpson, Paul, primary, McGhee, Ewan J., primary, Morton, Jennifer P., primary, von Kriegsheim, Alex, primary, Schwarz, Juliane P., primary, Karim, Saadia A., primary, Doyle, Brendan, primary, Quinn, Jean A., primary, Carragher, Neil O., primary, Edward, Mike, primary, Olson, Michael F., primary, Frame, Margaret C., primary, Brunton, Valerie G., primary, Sansom, Owen J., primary, and Anderson, Kurt I., primary

Published
2023
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44. Data from Spatial Regulation of RhoA Activity during Pancreatic Cancer Cell Invasion Driven by Mutant p53

Author

Timpson, Paul, primary, McGhee, Ewan J., primary, Morton, Jennifer P., primary, von Kriegsheim, Alex, primary, Schwarz, Juliane P., primary, Karim, Saadia A., primary, Doyle, Brendan, primary, Quinn, Jean A., primary, Carragher, Neil O., primary, Edward, Mike, primary, Olson, Michael F., primary, Frame, Margaret C., primary, Brunton, Valerie G., primary, Sansom, Owen J., primary, and Anderson, Kurt I., primary

Published
2023
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45. Supplementary Figure 10 from Spatial Regulation of RhoA Activity during Pancreatic Cancer Cell Invasion Driven by Mutant p53

Author

Timpson, Paul, primary, McGhee, Ewan J., primary, Morton, Jennifer P., primary, von Kriegsheim, Alex, primary, Schwarz, Juliane P., primary, Karim, Saadia A., primary, Doyle, Brendan, primary, Quinn, Jean A., primary, Carragher, Neil O., primary, Edward, Mike, primary, Olson, Michael F., primary, Frame, Margaret C., primary, Brunton, Valerie G., primary, Sansom, Owen J., primary, and Anderson, Kurt I., primary

Published
2023
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47. Supplementary Figure 6 from Spatial Regulation of RhoA Activity during Pancreatic Cancer Cell Invasion Driven by Mutant p53

Author

Timpson, Paul, primary, McGhee, Ewan J., primary, Morton, Jennifer P., primary, von Kriegsheim, Alex, primary, Schwarz, Juliane P., primary, Karim, Saadia A., primary, Doyle, Brendan, primary, Quinn, Jean A., primary, Carragher, Neil O., primary, Edward, Mike, primary, Olson, Michael F., primary, Frame, Margaret C., primary, Brunton, Valerie G., primary, Sansom, Owen J., primary, and Anderson, Kurt I., primary

Published
2023
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48. Supplementary Movie 2 from Intravital FLIM-FRET Imaging Reveals Dasatinib-Induced Spatial Control of Src in Pancreatic Cancer

Author

Nobis, Max, primary, McGhee, Ewan J., primary, Morton, Jennifer P., primary, Schwarz, Juliane P., primary, Karim, Saadia A., primary, Quinn, Jean, primary, Edward, Mike, primary, Campbell, Andrew D., primary, McGarry, Lynn C., primary, Evans, T.R. Jeffry, primary, Brunton, Valerie G., primary, Frame, Margaret C., primary, Carragher, Neil O., primary, Wang, Yingxiao, primary, Sansom, Owen J., primary, Timpson, Paul, primary, and Anderson, Kurt I., primary

Published
2023
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