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Background: Late recurrence of breast cancer after 5 years accounts for about 50% of recurrences in hormone receptor (HR)-positive early breast cancer (EBC). TAILORx established non-inferiority of adjuvant endocrine therapy (ET) given for at least 5 years to chemotherapy plus ET (CET) in EBC and a 21-gene recurrence score (RS) of 11-25, although there was some chemotherapy benefit in women Methods: Eligibility criteria included women 18-75 years with HR-positive, HER2-negative, T1b-T2N0 EBC who agreed to have CT assigned or randomized based on the RS assay. The primary endpoint was invasive disease-free survival (iDFS) in the RS 11-25 group. The “primary analysis” refers to the original prespecified analysis for the primary IDFS endpoint (836 IDFS events at full information in the RS 11-25 group) after a median of 7.5 years. The “updated analysis” was performed after a median followup of 11.0 and 10.4 years in the randomized and overall populations, respectively. Results:10,253 eligible women enrolled between 4/7/06-10/6/10.The updated analysis includes substantially more events that the primary analysis, including IDFS events (1819 vs. 1210), distant recurrences (561 vs. 384), locoregional +/- distant recurrences (764 vs. 543), and deaths (910 vs. 499). The table provides 5 and 12-year event rates (and standard errors) for all arms, and comparisons of the randomized arms. The primary trial conclusions remain unchanged: ET was non-inferior to CET in the randomized group with a RS 11-25. Although recurrence occurred in < 10% by 12 years for a RS 0-25, late recurrence events beyond 5 years exceeded earlier recurrence. Non-recurrence events occurred in about 13% at 12 years (~1%/year), contributing substantially to the IDFS rates. For women Conclusions: The current updated analysis confirms findings from the original primary analysis that ET is non-inferior to CET in HR-positive, HER2-negative, node-negative EBC and a RS 11-25. As in the original primary analysis, the subgroup of women Citation Format: Joseph Sparano, Robert J. Gray, Della Makower, Kathy S. Albain, Daniel F. Hayes, Charles Geyer, Elizabeth Dees, Matthew P. Goetz, John A. Olson Jr, Tracy G. Lively, Sunil Badve, Thomas Saphner, Lynne I. Wagner, Timothy Whelan, Virginia Kaklamani, George Sledge. Trial Assigning Individualized Options for Treatment (TAILORx): An Update Including 12-Year Event Rates [abstract]. In: Proceedings of the 2022 San Antonio Breast Cancer Symposium; 2022 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2023;83(5 Suppl):Abstract nr GS1-05.

Uncontrolled studies suggest that the addition of high dose rate intraluminal brachytherapy (HDRIB) to external beam radiotherapy (EBR) may improve palliation for patients with advanced non-small cell lung cancer (NSCLC). The purpose of this study was to evaluate the potential clinical benefit of adding HDRIB to EBR in a multicenter randomized trial.Patients with symptomatic stage III or IV NSCLC with endobronchial disease were randomized to EBR (20Gy in 5 daily fractions or 30Gy in 10 daily fractions) or the same EBR+HDRIB (14Gy in 2 fractions over two weeks). The primary outcome was the proportion of patients who achieved symptomatic improvement in patient-reported overall lung cancer symptoms on the Lung Cancer Symptom Scale (LCSS) at 6 weeks following randomization. Secondary outcomes included improvement in individual symptoms, symptom progression free survival, overall survival and toxicity. The planned sample size was 250 patients based on detection of symptomatic improvement from 40 to 60% with a two-sided α of 0.05 and 80% power.134 patients were randomized over 4.5 years: 67 to each arm. The study closed early due to slow accrual. The mean age was 69.8 years, and 67% had metastatic disease. At six weeks 19 patients (28.4%) in the EBR arm and 20 patients (29.9%) in the EBR+HDRIB arm experienced an improvement in lung cancer symptoms (p=0.84). When limited to patients who completed the LCSS percentages were 40.4% vs 47.6%, respectively, p=0.49. Between group differences in mean change scores (0.3-0.5 standard deviations) in favor of EBR+HDRIB were observed for overall symptoms, but only hemoptysis was significantly improved (p=0.03). No significant differences were observed in progression free or overall survival. Grade 3/4 toxicity was similar between groups.Small to moderate improvements were seen in symptom relief with the combined therapy, but they did not reach statistical significance. Further research is necessary before recommending HDRIB in addition to EBR for palliation of lung cancer symptoms.

The study of print culture and the history of the book in the eighteenth century has benefited significantly in the past three decades from studies that have placed varying degrees of emphasis on the three key components of print culture—author, publisher, and reader—and their interwoven relationships. This scholarship has also spurred new research on the literary and print culture of evangelical Anglicans, Methodists, Quakers, Calvinistic Methodists, Baptists, Moravians, and Independents in Great Britain and America, including specific studies related to the transatlantic nature of the printing histories of Philip Doddridge and Jonathan Edwards. This chapter seeks to further this discussion by exploring three areas of eighteenth-century evangelical print culture in England: the interplay between readers, writers, and producers with informal and formal sources; the ecclesiastical/topographical reconstruction of reading/selling communities of chapel-goers and neighboring (and usually like-minded) booksellers; and the interaction of these two elements in the publishing history of one representative text, Samuel James’s An Abstract of the Gracious Dealings of God with Several Eminent Christians (1760).

As part of its new Friends of the Angus initiative, The Angus Library and Archive has organised a series of online lectures, ‘Opening the Angus’, for Friends to enjoy. In the following report, our ...

Rationale Two antifibrotic medications, nintedanib and pirfenidone, have been approved for the treatment of idiopathic pulmonary fibrosis (IPF) in the US. Few data have been published on the use of these medications in clinical practice. Objective To investigate patterns of use of antifibrotic medications in the US. Methods The IPF-PRO Registry, a multicenter US registry, has enrolled patients with IPF that was diagnosed or confirmed at the enrolling center in the past 6 months. Data from patients enrolled from 5 June 2014 to 4 March 2018 were used to determine antifibrotic medication use ("treatment") in the enrollment window and a follow-up window approximately 6 months later. Associations between patient characteristics and treatment status were tested using logistic regression. Results Overall, 551 of 782 eligible patients (70.5%) were treated in the enrollment window. Younger age, lower FVC % predicted, oxygen use with activity, worse self-rated health based on the Short Form-12 (SF-12) or St George's Respiratory Questionnaire score, referral to the enrolling center by a pulmonologist, use of lung biopsy in diagnosis, and carrying a diagnosis of IPF to the enrolling center were associated with being treated. Among 534 patients treated at enrollment who had follow-up data, 94.0% remained treated in follow-up. Better self-rated health based on the SF-12 mental component score or EuroQoL score, and not using oxygen with activity at enrollment, were associated with continuing treatment in follow-up. Among 172 patients who were untreated at enrollment and had follow-up data, 29.7% started treatment in follow-up. Lower DLco % predicted, a family history of ILD, a history of sleep apnea, and a definite diagnosis of IPF at enrollment were associated with starting treatment in follow-up. Conclusions The majority of patients in the IPF-PRO Registry were receiving an approved medication for IPF at enrollment. Treatment at enrollment was associated with greater disease severity, more compromised quality of life and the use of oxygen with activity. Clinical trial registered with ClinicalTrials.gov (NCT01915511).

Though Baptist historians have placed considerable emphasis upon the lives and careers of prominent ministers, recent archival work has revealed much about the lives, careers, and activities of lay...

A circle of Dissenting women writers that began in the 1770s, centred on Mary Steele of Broughton and Elizabeth Coltman of Leicester, merged in the 1790s in London with a group of Dissenting literary women and men revolving around William Godwin, Mary Hays and Crabb Robinson, a phenomenon revealed almost exclusively through informal life-writings and poems, most of which have remained in manuscript. This cross-pollination of women's literary coteries reveals much about how eighteenth-century women's literary networks were formed and perpetuated, how they overcame geographical boundaries and how they enriched the lives of their members and their male friends.

A fresh examination of the life-writings of Henry Crabb Robinson, which are now being prepared for a new edition, reveals new details about the lives and times of several writers considered "minor" in the 1930's, when Edith Morley prepared her monumental edition, Henry Crabb Robinson on Books and Their Writers (3 vols, 1938). (1) Those volumes have served as the starting and ending point for information (sometimes firsthand, sometimes anecdotal) by Robinson on scores of writers, male and female, from England, America, and Europe gathered during his long life (1775-1867). (2) Mary Hays is an example. Morley inserted eight references by Robinson to Hays in Books and Their Writers: one from his 1799 reminiscences, one from an 1805 letter, three from his diary for 1813, and one from 1817, 1819, and 1843 (1: 5-7, 124-25, 128, 130-31, 212, 234-35; 2: 629; 3:843-44). (3) The exigencies of print precluded Morley, however, from recording all references to Hays by Robinson throughout his voluminous life-writings. Important additions to Morley's work on Robinson and Hays appear in Marilyn Brooks's edition of Hays's correspondence (which includes twelve letters that passed between Hays and Robinson between 1802 and 1842) and Gina Luria Walker's biography of Hays. (4) Robinson's friendship with Hays, however, has been significantly expanded through the uncovering of nearly 180 references to Hays (composed between 1799 and 1859) in Robinson's diary, reminiscences, and correspondence. These references establish Hays as the most dominant woman writer in Robinson's life-writings, a tribute to their friendship as well as his appreciation of Hays's intellect and literary abilities. (5) Robinson's life-writings focus primarily on Hays's activities after 1803, a period Gina Walker called her "buried life" (Mary Hays 234-37) that commenced with Hays's monumental publication, Female Biography, or, Memoirs of Illustrious and Celebrated Women, of All Ages and Countries. Modern editions of Hays's major texts through 1803 illuminate her writing but not her biography. (6) Recovering her bio-text, reconstituting her life within a geographical, social, and religious setting, requires informal sources: diaries, letters, newspaper notices, church books, marriage and death certificates, and detailed genealogical records. For Hays, Crabb Robinson is such a source. As his life-writings become more accessible to scholars, Hays's relationship with Robinson expands in new ways, revealing three fundamental connections between the dedicated diarist and the outspoken feminist: a religious connection as life-long Dissenters; a familial connection through the marriages of two of Hays's nieces to relations (by marriage) of Robinson, marriages that remained strictly within the household of Dissent; and, most important, a cultural connection, one that flourished in the 1790s through the intertwining of several circles of liberal Dissenters and radicals in London and the provinces. These connections became evident in their initial meeting in the spring of 1799, and were further sealed in Robinson's stunning defense of Hays against Charles Lloyd in his letter to Catherine Clarkson the following January, a letter that foreshadows the central features in their enduring friendship that spanned more than forty years. Though known as a heterodox Unitarian and rational Dissenter, Mary Hays was raised an orthodox Calvinist, the third of four daughters of John (c. 1725-74) and Elizabeth Judge Hays (c. 1730-1811) of Gainsford Street, Southwark, near the wharves along the south side of the Thames where the family conducted its business as corn and flour factors and worshiped in the Particular Baptist chapel at the end of the street. (7) Mary's elder sister, Joanna (1754-1805), married John Dunkin (1753-1827) in July, 1774, just three months after the death of Mr. Hays. Mrs. Hays never remarried, living for many years in the family home in Gainsford Street, usually with one or more of her children while conducting business as a wine merchant (Universal British Directory, 1, part 2: 174). …

In the West Country of England between 1720 and 1840 a remarkable circle of nonconformist (primarily Baptist) women writers, largely unknown today, emerged in the vicinity of Salisbury and eventual...

Henry Crabb Robinson (1775-1867), diarist, traveler, and friend of nearly every important literary figure in England and Germany during the first half of the 19th century, considered the Wordsworths of Rydal Mount and their relations and friends in the Lake District his most important social circle outside his own family. His friendship with Mary Wordsworth (1770-1859) spanned nearly fifty years, though initially William and Dorothy were his primary correspondents. More than 100 letters passed between Robinson and Wordsworth and Dorothy from 1810 to 1835.(1) As Dorothy's mind deteriorated in the mid-1830s, Robinson transferred his attentions to William and Mary. If any letters passed between Robinson and Mary Wordsworth prior to 1833, they are no longer extant, nor are they mentioned in Robinson's chary. However, 129 letters composed between 1833 and 1858 have survived., eighty-three by Robinson and forty-six by Mary Wordsworth. The bulk of their correspondence belongs to the Robinson archive at Dr. Williams's Library, London, from which Edith Morley published the complete texts of Mary's letters an.d brief portions of Robinson's in The Correspondence of Henry Grubb Robinson with The Wordsworth Circle (2 vols, 1927). However, thirty-seven letters by Robinson to Mary Wordsworth, now in the Wordsworth Library, Grasine re, mostly addressed to her during the last ten years of her life are absent from Morley's Correspondence.(2) How these letters became separated from the Robinson collection at Dr. Williams's Library and thus escaped Morley's notice is a mystery, but their contents have continued to elude scholars of the Wordsworth circle and Crabb Robinson. Though the publication of Mary Wordsworth's letters is now complete, scant attention has been accorded Robinson's letters to her.(3) Scholars have generally relied on Morley's published portions of Robinson's. letters to Mary Wordsworth, as well as excerpts pertaining to her from his manuscript Diary and Reminiscences that appeared in Thomas Sadler's Diary, Reminiscences, and Correspondence of Henry Crabb Robinson (3 vols, 1869) and later in Morley's Henry Crabb Robinson on Books and Their Writers (3 vols, 1938) and Derek Hudson's The Diary of Henry Crabb Robinson: An Abridgement (1967). These publications have resulted in a highly selective and, at times, distorted view of the relationship between Robinson and Mary Wordsworth. From Mor-ley's volumes one primarily learns about Robinson's assistance in various matters of business and legal affairs on behalf of Wordsworth, especially with publishers and the successive editions of his poetry, and, in a lighter vein, his frequent purchases .of candles, soaps, and wedding gifts for Mary Wordsworth and her children as well as her gifts to him of knitted stockings and news of the Wordsworth circle and local gossip at Grasmere and nearby Ambleside. Robinson's letters, however, more than Mary's, reveal the depth of their friendship and the breadth of their shared and, at times, varied interests in literature, religion and politics, as well as the activities and opinions (both good and bad) of their wide coterie of friends and family members. According to Morley, their correspondence "shows the writers setting clown their thoughts and feelings in unrestrained freedom of intercourse" (Correspondence 1: 27). This "unrestrained freedom" was apparent to Morley because of her access to their correspondence at Dr. Williams's Library. Despite knowing the full content of Robinson's letters, she nevertheless published truncated versions in her Correspondence. thus reducing him, as Sadler had largely done, to a compiler of literary anecdotes. Though Robinson understood the importance of recording incidents relating to Wordsworth and his literary. friends, his letters to Mary Wordsworth exceed brief encounters with literary history, as the following discussion of the letters in the Wordsworth Library will make clear. Crabb Robinson became acquainted with the poetry of Wordsworth in the late 1790s through his former Bury friend and then resident of the Lakes, Catherine Buck Clarkson (1770-1856). …

Within the holdings of The University of Manchesters John Rylands Library is a remarkable collection of 337 letters to and from Baptist ministers and laypersons written between 1741 and 1907. Nearly half (165) can be found among the autograph collections of Thomas Raffles (1788-1863), Liverpool Congregationalist minister and educator, with another 103 letters belonging to the collections of the Methodist Archives. John Sutcliff (1752-1814), Baptist minister at Olney and an early leader within the Baptist Missionary Society, was the recipient of more than seventy of these,letters. Among the correspondents are the leading Baptist and Congregationalist ministers of the eighteenth and nineteenth centuries. Although largely unknown today, these letters provide important insights into British Baptist history between 1740 and 1900, establishing the John Rylands Library,as a valuable resource for Baptist historians.

In the West Country of England, between 1720 and 1840, a remarkable circle of nonconformist. (primarily Baptist) women writers emerged in the vicinity of Salisbury and eventually stretched in all directions, to Bristol, Southampton. London, and Leicester. 'The circle encompassed three generations of women writers, beginning in Broughton, Hampshire, with three Baptist women: the diarist, Anne Cator Steele (1689-1760): her talented stepdaughter and poet, Anne (1717-78), who Published Poems on Subjects Chiefly, Devolional in 1760 under the nom de plume "Theodosia"; and her natural daughter, Mary (1724-72), also a gifted poet but whose style differed significantly from that of her more famous sister. The second generation was led by Mary Steele (1753-1813). Anne Calor Steele's granddaughter and Anne Steele's niece, whose reputation as a poet, though eclipsed by (and later even confused with) that of her aunt, was sufficient to sustain her own coterie of literate friends, including Mary Scott (1751-93) of Milborne Port, Somerset, author of The Female Advoeate (1774): Jane Attwater (1753-1843) of Bodenham, Wiltshire, a prolific diarist: and Elizabeth Coltman (1761-1838) of Leicester, Steele's close friend during her later years and who was herself a poet and author of moral and political tracts. The third generation centered upon the poet Maria Grace Andrews Saffery (1772-1858), and her sister, Anne (1774-1865), who came to Salisbury from London in the early 1790s and, through their marriages, became friends and relations of the Steele and Attwater families. Saffery published a narrative poem, Cheyl sing (1790): a novel, The Noble Enthusiast (1792), printed by William Lane and the Minerva Press; and Poems on Sacred Subjects (1831). (2) Besides their obvious religious and literary connections, these nonconformist women all shared an interest in politics, fearing the threat of French oppression against the English and warning against British intolerance toward the American colonies, steadfastly opposing the war with France throughout the Napoleonic ear and never wavering in their opposition to the slave trade. This tradition of political engagement by women in the Steele circle began with Anne Cator Steele in 1730. and continued through the Seven Years' War. The Steeles, like many West Country dissenters, followed politics closely, often out of necessity as dissenters, watchful of any action by the government that might erode the toleration (limited as it was) that had been granted them in the aftermath of the Glorious Revolution. They also possessed an abiding sense of loyalty to the British throne and its defense of Protestantism against the ongoing threat of Catholic aggression by the French and the Spanish. On Friday, July 31, 1730, Steele writes that she has been in a "quiet peaceable frame reading a great deal of [y.sup.e] time in a large History of [y.sup.e] Monarchs of England, (3) and by reading that about [y.sup.e] powder plot I found my affections warm'd and drawn out to praise God in my evening duty" (Whelan, Nonconformist 8.44).Dissenters in the West Country feared a renewal of hostilities between England and France, not only because of Papal aggression, as Steele frequently mentions in her diary, but also because of English "iniquitys" Steele writes on Thursday, July 8, 1731: I was much the same this morning but it wore off with the company of the day yet I was fir'd up by hearing something in the news of the threachery against this nation by the Spanish & french the first having sent our fleet away & now they say there is 25 thousand French coming tis tho't to invade us, yet I am confident there is nothing but sin can hurt us if our iniquitys be full as indeed I have a great deal of reason to fear tho what can we expect but destruction vet I will endevour to cry to the lord please because the tho'1s of desolation is terible. (Whelan, Nonconformist 8:53) Steele rulers to a recent altercation between England and Spain, in which a Spanish commander cut off the car of Robert Jenkins of the British ship, Rebecca. …

Between 1791 and 1794, William Fox, a Dissenter, collaborated with the Baptist bookseller Martha Gurney in publishing sixteen political pamphlets on topics ranging from the abolition of the slave trade to the perversion of national fast days to Pitt's provocative war with France. Fox's first pamphlet, An Address to the People of Great Britain, on the Propriety of Refraining from the Use of West India Sugar and Rum (1791), became the most widely distributed pamphlet of the eighteenth century. It solidified the abolitionist forces in Great Britain and America by focusing their energies on a boycott of West Indian produce. Though scholars have recognized the historical significance of An Address to the People of Great Britain , Fox has never received proper credit as the author. Neither has Martha Gurney been recognized for her achievement as London's leading female Dissenting printer/bookseller during the 1780s and '90s.

Dr Whelan has made a study of Baptist letters in various British archives. The introduction to this calendar, which is helpfully collated with letters in the Isaac Mann Collection, looks at how the Rylands’ collection was assembled. Whelan’s transcriptions of many of these letters will be published in Baptist Autographs at the John Rylands University Library of Manchester, 1741-1845, Mercer 2009.

A document recently found among Joseph Angus’s papers in the Angus Library provides for the first time an eyewitness account of Robert Hall’s mental disturbance in 1804.

Jane Attwater’s friendship with Mary Steele was so deep that it served as the model for Danebury, Steele’s narrative poem about “The Power of Friendship” between two young girls about the same age as Steele and Attwater in 1768, the year the poem was composed. After the poem’s publication in 1779, Steele sent Attwater a copy with the fol-lowing inscription: Sylvia cannot transmit this little Pamphlet to the Friend of her heart without reminding her from whom those Ideas of Friendship arose which it feebly attempts to describe without recollecting with enthusiastic tenderness those happy hours when her Myrtilla taught her “Ere she knew its name to feel its Power” & however deficient she is in every other respect her Bosom still glows with the ardent wish of being what Emma was to Elfrida A Faithful Friend[.] (NWW 3: 390, n. 2)

The 14th St Gallen International Breast Cancer Conference (2015) reviewed substantial new evidence on locoregional and systemic therapies for early breast cancer. Further experience has supported the adequacy of tumor margins defined as 'no ink on invasive tumor or DCIS' and the safety of omitting axillary dissection in specific cohorts. Radiotherapy trials support irradiation of regional nodes in node-positive disease. Considering subdivisions within luminal disease, the Panel was more concerned with indications for the use of specific therapies, rather than surrogate identification of intrinsic subtypes as measured by multiparameter molecular tests. For the treatment of HER2-positive disease in patients with node-negative cancers up to 1 cm, the Panel endorsed a simplified regimen comprising paclitaxel and trastuzumab without anthracycline as adjuvant therapy. For premenopausal patients with endocrine responsive disease, the Panel endorsed the role of ovarian function suppression with either tamoxifen or exemestane for patients at higher risk. The Panel noted the value of an LHRH agonist given during chemotherapy for premenopausal women with ER-negative disease in protecting against premature ovarian failure and preserving fertility. The Panel noted increasing evidence for the prognostic value of commonly used multiparameter molecular markers, some of which also carried prognostic information for late relapse. The Panel noted that the results of such tests, where available, were frequently used to assist decisions about the inclusion of cytotoxic chemotherapy in the treatment of patients with luminal disease, but noted that threshold values had not been established for this purpose for any of these tests. Multiparameter molecular assays are expensive and therefore unavailable in much of the world. The majority of new breast cancer cases and breast cancer deaths now occur in less developed regions of the world. In these areas, less expensive pathology tests may provide valuable information. The Panel recommendations on treatment are not intended to apply to all patients, but rather to establish norms appropriate for the majority. Again, economic considerations may require that less expensive and only marginally less effective therapies may be necessary in less resourced areas. Panel recommendations do not imply unanimous agreement among Panel members. Indeed, very few of the 200 questions received 100% agreement from the Panel. In the text below, wording is intended to convey the strength of Panel support for each recommendation, while details of Panel voting on each question are available in supplementary Appendix S2, available at Annals of Oncology online., 0, SCOPUS: ar.j, info:eu-repo/semantics/published

Mary Steele exhibited a lifelong commitment to her poetry and her coterie of female kindred spirits. She also relied heavily upon a particular pastoral persona, hinted at in her first poem, as well as in her choice of the nom de plume “Sylvia,” a name derived from the Latin word “Silvia” (a spelling also used by Steele), which means “woods” or “forest.” In “A Rural Meditation, 1766,” the poet seeks retirement in nature, what Margaret Doody calls the “trope of isolation” with its accompanying moods of melancholy, a “nearly universal” feature of British poetry after 1750 (229).1 In this instance, however, the isolated setting serves as a site from which to bask in the intimacy of female friendship and the pleasures of artistic freedom, merging the solitary and communal into a unified voice unlike the “unitary” voice often associated with Romantic poetry. In those “beauteous sylvan scenes” at her uncle’s estate at Yeovil, Sylvia feels secure enough to allow her “feet” and imagination “to stray,” a security sealed by a pleasing sociability she shares with her fellow-poets Myra and Celia (Mary Scott and Miss Williams) (NWW 3: 51). Mary Steele’s natural, almost earthy, persona—a fiercely independent single woman-poet inspired by a rural muse in a secluded setting shared by a community of female friends—stands in stark contrast to her aunt’s near-beatified role as Theodosia, the heavenly hymn writer.

In 1843, John Holland, in The Psalmists of Britain, boasted, “There are few names of more certain occurrence in modern collections of Psalms and Hymns than that of Mrs. Steele—but still fewer, there is reason to believe, of whom less has been known, even by the majority of those persons who have adopted her compositions.” His reference is to Anne Steele (she never married, despite Holland’s use of “Mrs.”), whose poetry, he adds, “veiled under an assumed name [Theodosia], was comparatively unknown beyond the circle of her personal friends” (2: 223).1 Holland had only a slight understanding of the quality and breadth of the coterie of male and female writers surrounding Anne Steele. Otherwise, he would have known that she was neither “veiled” nor “unknown” in the second half of the eighteenth century, though by 1843 both her poetry and her literary circle were indeed not widely known. Holland’s information on Steele came mostly from Hugh Russell, the minister at the Broughton Baptist Church (1809–49) where the Steele family had worshiped since the late 1600s. Holland did discover one fact during his visit to Broughton that was not known in 1843 beyond the small “circle” familiar with the Steele family, and that was that Anne Steele was not the only talented poet to emerge from her family in the eighteenth century.

Mary Steele’s life and poetry may have been veiled by anonymity and obscurity, but Mary Scott and her major poems, The Female Advocate (1774) and Messiah (1788), have been known for more than two centuries. Nevertheless, Scott’s identity and biography have likewise suffered from misidentification and numerous inaccuracies. Commentators on Scott have relied heavily on information taken from nine letters by Anna Seward (1747–1809) to Scott and one by Seward to her friend William Hayley, all composed between 1786 and 1793 and published in Archibald Constable’s six-volume edition of The Letters of Anna Seward (1811).1 Seward’s letters provide important background about Scott’s reading and literary interests, as well as her health, courtship, and marriage to John Taylor (1752–1817), but Seward’s assertion to Hayley on May 10, 1788, that Scott’s “Father was a Clergyman of the Church of England” (NWW 4: 290) set later commentators on an erroneous path. In the mid-1980s, nearly two hundred years after her death, when Gae Holladay and Moira Ferguson began the pioneering work of resurrecting Mary Scott as a significant eighteenth-century feminist writer, they still used Seward’s letters as a starting point for Scott’s life. To Holladay, Mary Scott was, like Seward, an Anglican Bluestocking “enjoying a literary life among a small circle, composing poems for private circulation or subscription publication, contributing to miscellany volumes … overseeing editions of [her] works, or contributing poems to one of many editions of Poems by Eminent Ladies (1755) or Dodsley’s Collection of Poems (1748)” (iii–iv).

In the mid-1780s the Steele circle expanded beyond the West Country to Leicester, in the Midlands, welcoming Elizabeth Coltman as the final addition to the second generation centered upon Mary Steele. Coltman and her sisters were educated at a boarding school at Stoke Newington, Hackney, possibly the same boarding school Mary Steele attended between 1766 and early 1769, but, if not, one close enough that the girls may have attended the same dissenting chapel (Skillington 8). Most likely Elizabeth came to know Mary Steele through her older sister Anne Coltman (1753–88), who was born the same year as Steele and would have attended school either with Steele or possibly Mary Scott. Elizabeth Coltman was eight years Steele’s junior and it seems unlikely she would have attended boarding school at the same time, although it is possible that in autumn 1768 or the early months of 1769 (Steele’s last term in London), Anne, Elizabeth, and their other sister Mary (1757–1834), at that time aged 15, 11, and 7, could have been attending together. Whatever the case, Steele’s friendship with Coltman flourished in the 1780s, with Coltman evenutally succeeding Mary Scott as Steele’s “kindred soul.”

Recently, an unpublished, undated letter by Samuel Taylor Coleridge (in London) to Samuel Purkis (at Brentford), composed between February 26 and March 1, 1800, was found in a collection of autograph letters once belonging to the Baptist minister Joseph Angus (1816–1902), principal of Regent’s Park College, London, from 1849 to 1893. In the letter, Coleridge requests a loan of £10 from Purkis to be sent to Coleridge’s mother‐in‐law in Bristol in order to defray expenses that would soon arise from Sara Coleridge’s visit in March to the West Country. In the letter, Coleridge refers to Richard B. Sheridan as “a Rogue,” boasts of having spent considerable time with Elizabeth Inchbald, Charlotte Smith, Mrs Barbauld, and Mary Robinson (Coleridge’s “list of Illustrissimae!”), and once again declares his intention of giving up newspaper work and returning to the West Country to live for a time with Tom Poole. This essay discusses Coleridge’s past history with Purkis, Coleridge’s current situation with the Morning...

During the 1790s, perhaps no radical was more consistent in his criticism of the policies of the Pitt administration and his advocacy of political reform than Benjamin Flower (1755-1829), editor of the Cambridge Intelligencer from 1793 to 1803. Flower, like many other radicals, paid for his political opinions--six months in Newgate in 1799 for calling the Bishop of Llandaff "the Right Reverend time server and apostate" (Cambridge Intelligencer, April 20, 1799). Flower later described the government's efforts to silence him as a great blessing, for "considering my late imprisonment, with all its circumstances, my heart cannot but expand with gratitude to that all-wise and all-gracious providence, who in the concerns of individuals as well as in the concerns of the universe, brings order out of confusion, and good out of evil" (Proceedings 31). The "order" and "good" were the result of his relationship with Eliza Gould (1770-1810), a twenty-nine-year-old governess whom he met in July, 1799, while in Newgate. They were engaged two months later and married on January 1, 1800. Even before their first meeting, their lives had intertwined in the early 1790's while Eliza was serving as a governess and schoolmistress in Devon. Of the correspondence, only her letters to Flower have survived, along with some other letters she wrote between 1794 and 1799. Her letters reveal a woman of intellectual and spiritual integrity, literary aspirations, radical political opinions, and deeply held romantic ideals, determined to find intellectual fulfillment, financial security, and domestic happiness in the midst of circumstances that constantly threatened her with the loss of all three. (1) Born in Bampton, Devon, where her father, John Gould, was a tanner and deacon/trustee in the local Baptist church, Eliza was educated, first, in a school conducted by the local Baptist minister's wife, then by her father who allowed her to follow her own inclinations, inclinations that led her to adopt democratic ideals and romantic notions. "Plutarch--Telemachus & Jerusalem delivered--The tender Fenelon," she later wrote, moved my heart & Tasso fired my imagination--with Telemachus I read Eucharis & Herminion with Tancred--completely transformed into those personages I had no consciousness of any other existence--I reflected not on myself I was regardless of everything around me I was the very characters themselves & I saw only the objects that existed for them--the works which I have been speaking of gave place to others & their impressions were softened Some of the writings of Voltaire in particular were instrumental in producing this effect-- father made some whimsical presents of books for instance he gave me Fenelon on female education & Locke on the Education of Children thus putting into the hand of the pupil what was designed for the tutor but it was of service ... Rousseau['s] Heloise I was acquainted with a considerable number of contin [ental] historians learned one[s] & philosophers but Rousseau made an impression on me similar to that which Plutarch had done when I was eight years old it appear's that this was the proper food for my mind & the intestines of those Ideas which I entertained but which he alone knew how to explain to me Plutarch had prepared me to become a republican he roused that strength & stateliness of character which constitute one--he inspired me with a real enthusiasm in favor of public virtues & liberty Rousseau pointed out to me the domestic Happiness to which I could aspire & the ineffable enjoyments which I was capable of tasting ... I was arrived at considerable maturity I love[d] to reflect I thought with seriousness of forming my character that is I studied [the] movements of my mind. I sought to know myself I felt I had a destination which I must enable myself to fill--The regularity of a life occupied with a variety of exercises was perfectly suitable to the activity of my mind as well as to my natural taste for method & application. …

Joseph Angus and Thomas Raffles both collected autographs. For Angus the signatures of authors were a means of enhancing the academic dignity of the college collection. Transcripts of his letters to Raffles are included.