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Objective: The Warburg effect describes the ability of cancer cells to reorganize their metabolic pathway, so that the glycolysis can take place in normoxic and hypoxic condition. Thus, the increased energy demand of cancer cells can be covered. ENO1 (α-Enolase), a glycolytic enzyme, contributes [for full text, please go to the a.m. URL]

Objective: The determination of the presence of tumor in biopsies and the decision-making during resections is often dependent on intraoperative histological tissue sample assessment. Recently, stimulated Raman scattering microscopy has been introduced to rapidly generate virtual hematoxylin-and-eosin-stained-like [for full text, please go to the a.m. URL]

Objective: YAP1 (yes-associated protein 1) and its homologue TAZ (transcriptional activator with PDZ-binding motif) are transcriptional co-activators of the hippo pathway. This pathway plays an important role in the regulation of tissue growth during organ growth and regeneration. When the hippo-pathway [for full text, please go to the a.m. URL]

Objective: Brain tumors from different age groups come with variable characteristics. They differ in their molecular characteristics and in the patient’s outcome. Yes-associated Protein (YAP) and the homologous protein Transcriptional Co-Activator With PDZ-Binding Motif (TAZ) are transcriptional [for full text, please go to the a.m. URL]

Objective: The LRIG family of integral membrane proteins consists of LRIG1-3. While LRIG2 is believed to be a tumor promoter, LRIG1 and LRIG3 seem to function as tumor suppressors. In this study, we aim to analyze and compare the expression of LRIG1 in different types of gliomas. Methods: Tumor [for full text, please go to the a.m. URL]

Objective: UCHL1 is a neuron specific deubiquitinating enzyme, which recycles Ubiquitin, a small molecule regulating protein degradation by the Ubiquitin Proteasome System. Mutations in UCHL1 are associated with neurodegenerative diseases caused by protein accumulation. In tumours expression of UCHL1is [for full text, please go to the a.m. URL]

Objective: The LRIG gene family consists of LRIG1-3 which encode integral membrane proteins. While LRIG1 and LRIG3 are believed to be tumor suppressors, LRIG2 seems to function as a tumor promoter. It has been reported that LRIG2 expression is upregulated in gliomas and increases with higher tumor grade. [for full text, please go to the a.m. URL]

Objective: Low grade glioma (LGG) are heterogenous tumours, causing variable survival in patients. Identifying molecular markers for a more accurate prognosis is therefore important. Since death receptor 6 (DR6) is upregulated in glioma and shows an aberrant signalling network, we tested its suitability [for full text, please go to the a.m. URL]

Objective: The Aryl hydrocarbon receptor (AHR) is a ligand activated transcription factor initially linked to exogenic carcinogenic agents such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin). In 2011, the tryptophan (TRP) catabolite kynurenine (KYN) was identified as the first endogenous ligand [for full text, please go to the a.m. URL]

Objective: Intraventricular meningiomas (IVMs) are a rare subgroup accounting for less than 5% of all intracranial meningiomas. Recent studies showed evidence that IVMs are marked by a distinct chromosomal alteration with a combined loss of chromosome 22q and 1p. Here, we aim to map epigenetic [for full text, please go to the a.m. URL], 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Objective: In Meningioma, several Non-NF2 driver mutations (KLF4, TRAF7, SMO, AKT1E17K) have been shown to correlate with certain pathological subtypes, tumor locations and clinical features. Specifically, we have recently shown that the KLF4K409Q mutation may cause enhanced hypoxia signalling and correlates[for full text, please go to the a.m. URL], 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Objective: Training operation procedures is essential for patient safety. In consideration of the 3-R-rule (Refine-Replace-Reduce) as a guideline for promoting ethical use of animals for surgical training, we present a novel training model for microvessel anastomosis. Methods: In a rat cadaveric[for full text, please go to the a.m. URL], 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Objective: Percutaneous pedicle screw placement can be challenging in obese patients. The objective of this study was to compare complication rates, patient-reported outcomes and quality of life between obese and non-obese patients that underwent minimally invasive transforaminal lumbar interbody fusion[for full text, please go to the a.m. URL], 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

Objective: Checkpoint inhibitors such as Ipilimumab and Nivolumab have significantly improved survival in patients with inoperable or metastatic melanoma. Many cancers produce proteins that suppress the immunological response, specifically cytotoxic T-cells. Checkpoint inhibitors aim to block the inhibitory[for full text, please go to the a.m. URL], 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie

CORRIGENDUM Q. Miao, E. Zurlo, D. de Bruin, J. A. J. Wondergem, S. P. Skinner, M. Timmer, A. Blok, D. Heinrich, M. Overhand, M. Huber,* M. Ubbink* 17128–17133 A Two-Armed Probe for In-Cell DEER Measurements on Proteins Chem. Eur. J., 2020, 26 DOI: 10.1002/chem.202002743 All authors have agreed that Dr. Simon P. Skinner has made a significant contribution to this work by performing experiments and analyzing data and that his name should have been included in the list of authors. The corrected list of authors therefore reads: Dr. Qing Miao, Dr. Enrico Zurlo, Donny de Bruin, Joeri A. J. Wondergem, Dr. Simon P. Skinner, Monika Timmer, Anneloes Blok, Prof. Dr. Doris Heinrich, Dr. Mark Overhand, Dr. Martina Huber, Prof. Dr. Marcellus Ubbink The relevant affiliations for Dr. Skinner are (1) Leiden Institute of Chemistry, Gorlaeus Laboratories, Leiden University, Einsteinweg 55, 2333, CC Leiden, The Netherlands and (2) School of Molecular and Cellular Biology and Astbury Centre, University of Leeds, Leeds LS2 9JT, UK. The Acknowledgement section should not contain the sentence “and Dr. Simon Skinner for CLaNP5 labeled T4lys NMR data.

Introduction: For persons with hemophilia, optimization of joint outcomes is an important unmet need. The aim of this initiative was to determine use of ultrasound in evaluating arthropathy in persons with hemophilia, and to move toward consensus among hemophilia care providers regarding the preferred ultrasound protocols for global adaptation. Methods: A global survey of hemophilia treatment centers was conducted that focused on understanding how and why ultrasound was being used and endeavored to move toward consensus definitions of both point-of-care musculoskeletal ultrasound (POC-MSKUS) and full diagnostic ultrasound, terminology to describe structures being assessed by ultrasound, and how these assessments should be interpreted. Next, an in-person meeting of an international group of hemophilia health care professionals and patient representatives was held, with the objective of achieving consensus regarding the acquisition and interpretation of POC-MSKUS and full diagnostic ultrasound for use in the assessment of musculoskeletal (MSK) pathologies in persons with hemophilia. Results: The recommendations were that clear definitions of the types of ultrasound examinations should be adopted and that a standardized ultrasound scoring/measurement system should be developed, tested, and implemented. The scoring/measurement system should be tiered to allow for a range of complexity yet maintain the ability for comparison across levels. Conclusion: Ultrasound is an evolving technology increasingly used for the assessment of MSK outcomes in persons with hemophilia. As adoption increases globally for clinical care and research, it will become increasingly important to establish clear guidelines for image acquisition, interpretation, and reporting to ensure accuracy, consistency, and comparability across groups. © 2021 The authors. Research and Practice in Thrombosis and Haemostasis published by Wiley Periodicals LLC on behalf of International Society on Thrombosis and Haemostasis(ISTH).

Objective: Enhanced expression of TERT in gliomas is a result of two hotspot mutations, C228T and C250T, at the promoter region. The GABP of the ETS family selectively binds at these positions respectively causing an activation of the promoter and overexpression of TERT. GABP is a multimeric protein[for full text, please go to the a.m. URL], 71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie

Objective: Postoperative seizures represent a potential complication of surgical chronic subdural hematoma (cSDH) evacuation and may occur in 1 – 23% of cases. A risk factor analysis can help to identify patients that may benefit from anti-epileptic prophylaxis. Methods: This is a retrospective,[for full text, please go to the a.m. URL], 71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie

Objective Computer-aided design and manufacturing (CAD/CAM) implants are fabricated based on volumetric analysis of computed tomography (CT) scans and are routinely used for the reconstruction of orbital fractures. We present three cases of patients with sphenoorbital meningiomas that underwent tumor resection, orbital decompression, and orbital reconstruction with patient specific porous titanium or acrylic implants in a single procedure. Methods The extent of bone resection of the sphenoorbital meningiomas was planned in a virtual three-dimensional (3D) environment using preoperative thin-layer CT data. The anatomy of the orbital wall in the resection area was reconstructed by superimposing the contralateral unaffected orbit and by using the information of the neighboring bony structures. The customized implants and a corresponding craniotomy template were designed in the desired size and shape by the manufacturer. Results All patients presented with a sphenoorbital meningioma and exophthalmos. After osteoclastic craniotomy with the drilling template, orbital decompression was performed. Implant fitting was tight in two cases and could be easily fixated with miniplates and screws. In the third patient, a reoperation was necessary for additional bone resection, as well as drilling and repositioning of the implant. The postoperative CT scans showed an accurate reconstruction of the orbital wall. After surgery, exophthalmos was substantially reduced and a satisfying cosmetic result could be finally achieved in all patients. Conclusions The concept of preoperative 3D virtual treatment planning and single-step orbital reconstruction with CAD/CAM implants after tumor resection involving the orbit is well feasible and can lead to good cosmetic results. © 2020 Georg Thieme Verlag KG Stuttgart New York.