Search

Your search keyword '"Tilley, Wayne"' showing total 862 results
Start Over Author "Tilley, Wayne"
862 results on '"Tilley, Wayne"'

1. CDK9 inhibition inhibits multiple oncogenic transcriptional and epigenetic pathways in prostate cancer

Author

Rahman, Razia, Rahaman, Muhammed H., Hanson, Adrienne R., Choo, Nicholas, Xie, Jianling, Townley, Scott L., Shrestha, Raj, Hassankhani, Ramin, Islam, Saiful, Ramm, Susanne, Simpson, Kaylene J., Risbridger, Gail P., Best, Giles, Centenera, Margaret M., Balk, Steven P., Kichenadasse, Ganessan, Taylor, Renea A., Butler, Lisa M., Tilley, Wayne D., Conn, Simon J., Lawrence, Mitchell G., Wang, Shudong, and Selth, Luke A.

Published
2024
Full Text
View/download PDF

2. Library size confounds biology in spatial transcriptomics data

Author

Bhuva, Dharmesh D., Tan, Chin Wee, Salim, Agus, Marceaux, Claire, Pickering, Marie A., Chen, Jinjin, Kharbanda, Malvika, Jin, Xinyi, Liu, Ning, Feher, Kristen, Putri, Givanna, Tilley, Wayne D., Hickey, Theresa E., Asselin-Labat, Marie-Liesse, Phipson, Belinda, and Davis, Melissa J.

Published
2024
Full Text
View/download PDF

4. Author Correction: CDK9 inhibition constrains multiple oncogenic transcriptional and epigenetic pathways in prostate cancer

Author

Rahman, Razia, Rahaman, Muhammed H., Hanson, Adrienne R., Choo, Nicholas, Xie, Jianling, Townley, Scott L., Shrestha, Raj, Hassankhani, Ramin, Islam, Saiful, Ramm, Susanne, Simpson, Kaylene J., Risbridger, Gail P., Best, Giles, Centenera, Margaret M., Balk, Steven P., Kichenadasse, Ganessan, Taylor, Renea A., Butler, Lisa M., Tilley, Wayne D., Conn, Simon J., Lawrence, Mitchell G., Wang, Shudong, and Selth, Luke A.

Published
2024
Full Text
View/download PDF

5. The molecular consequences of androgen activity in the human breast

Author

Raths, Florian, Karimzadeh, Mehran, Ing, Nathan, Martinez, Andrew, Yang, Yoona, Qu, Ying, Lee, Tian-Yu, Mulligan, Brianna, Devkota, Suzanne, Tilley, Wayne T, Hickey, Theresa E, Wang, Bo, Giuliano, Armando E, Bose, Shikha, Goodarzi, Hani, Ray, Edward C, Cui, Xiaojiang, and Knott, Simon RV

Subjects
Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Biological Sciences, Breast Cancer, Genetics, Cancer, Sexual and Gender Minorities (SGM/LGBT*), Aetiology, 2.1 Biological and endogenous factors, androgen regulation of human breast homeostasis, breast microenvironment, cellular metabolism, chromatin regulation, hormone receptor, lactation, multiplexed immunohistochemistry by co-detection by indexing, single-cell ATAC sequencing, single-cell RNA sequencing, transcriptional control
Abstract

Estrogen and progesterone have been extensively studied in the mammary gland, but the molecular effects of androgen remain largely unexplored. Transgender men are recorded as female at birth but identify as male and may undergo gender-affirming androgen therapy to align their physical characteristics and gender identity. Here we perform single-cell-resolution transcriptome, chromatin, and spatial profiling of breast tissues from transgender men following androgen therapy. We find canonical androgen receptor gene targets are upregulated in cells expressing the androgen receptor and that paracrine signaling likely drives sex-relevant androgenic effects in other cell types. We also observe involution of the epithelium and a spatial reconfiguration of immune, fibroblast, and vascular cells, and identify a gene regulatory network associated with androgen-induced fat loss. This work elucidates the molecular consequences of androgen activity in the human breast at single-cell resolution.

Published
2023

8. Activity and safety of enobosarm, a novel, oral, selective androgen receptor modulator, in androgen receptor-positive, oestrogen receptor-positive, and HER2-negative advanced breast cancer (Study G200802): a randomised, open-label, multicentre, multinational, parallel design, phase 2 trial

Author

Palmieri, Carlo, Linden, Hannah, Birrell, Stephen N, Wheelwright, Sally, Lim, Elgene, Schwartzberg, Lee S, Dwyer, Amy R, Hickey, Theresa E, Rugo, Hope S, Cobb, Patrick, O'Shaughnessy, Joyce A, Johnston, Stephen, Brufsky, Adam, Tilley, Wayne D, and Overmoyer, Beth

Published
2024
Full Text
View/download PDF

9. An androgen receptor switch underlies lineage infidelity in treatment-resistant prostate cancer

Author

Davies, Alastair, Nouruzi, Shaghayegh, Ganguli, Dwaipayan, Namekawa, Takeshi, Thaper, Daksh, Linder, Simon, Karaoğlanoğlu, Fatih, Omur, Meltem E, Kim, Soojin, Kobelev, Maxim, Kumar, Sahil, Sivak, Olena, Bostock, Chiara, Bishop, Jennifer, Hoogstraat, Marlous, Talal, Amina, Stelloo, Suzan, van der Poel, Henk, Bergman, Andries M, Ahmed, Musaddeque, Fazli, Ladan, Huang, Haojie, Tilley, Wayne, Goodrich, David, Feng, Felix Y, Gleave, Martin, He, Housheng Hansen, Hach, Faraz, Zwart, Wilbert, Beltran, Himisha, Selth, Luke, and Zoubeidi, Amina

Subjects
Prostate Cancer, Genetics, Cancer, Stem Cell Research, Urologic Diseases, Aetiology, 1.1 Normal biological development and functioning, Underpinning research, 2.1 Biological and endogenous factors, Cell Line, Tumor, Enhancer of Zeste Homolog 2 Protein, Gene Expression Regulation, Neoplastic, Gene Regulatory Networks, Humans, Male, Prostatic Neoplasms, Receptors, Androgen, Signal Transduction, Biological Sciences, Medical and Health Sciences, Developmental Biology
Abstract

Cancers adapt to increasingly potent targeted therapies by reprogramming their phenotype. Here we investigated such a phenomenon in prostate cancer, in which tumours can escape epithelial lineage confinement and transition to a high-plasticity state as an adaptive response to potent androgen receptor (AR) antagonism. We found that AR activity can be maintained as tumours adopt alternative lineage identities, with changes in chromatin architecture guiding AR transcriptional rerouting. The epigenetic regulator enhancer of zeste homologue 2 (EZH2) co-occupies the reprogrammed AR cistrome to transcriptionally modulate stem cell and neuronal gene networks-granting privileges associated with both fates. This function of EZH2 was associated with T350 phosphorylation and establishment of a non-canonical polycomb subcomplex. Our study provides mechanistic insights into the plasticity of the lineage-infidelity state governed by AR reprogramming that enabled us to redirect cell fate by modulating EZH2 and AR, highlighting the clinical potential of reversing resistance phenotypes.

Published
2021

10. Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci

Author

Schumacher, Fredrick R, Al Olama, Ali Amin, Berndt, Sonja I, Benlloch, Sara, Ahmed, Mahbubl, Saunders, Edward J, Dadaev, Tokhir, Leongamornlert, Daniel, Anokian, Ezequiel, Cieza-Borrella, Clara, Goh, Chee, Brook, Mark N, Sheng, Xin, Fachal, Laura, Dennis, Joe, Tyrer, Jonathan, Muir, Kenneth, Lophatananon, Artitaya, Stevens, Victoria L, Gapstur, Susan M, Carter, Brian D, Tangen, Catherine M, Goodman, Phyllis J, Thompson, Ian M, Batra, Jyotsna, Chambers, Suzanne, Moya, Leire, Clements, Judith, Horvath, Lisa, Tilley, Wayne, Risbridger, Gail P, Gronberg, Henrik, Aly, Markus, Nordström, Tobias, Pharoah, Paul, Pashayan, Nora, Schleutker, Johanna, Tammela, Teuvo LJ, Sipeky, Csilla, Auvinen, Anssi, Albanes, Demetrius, Weinstein, Stephanie, Wolk, Alicja, Håkansson, Niclas, West, Catharine ML, Dunning, Alison M, Burnet, Neil, Mucci, Lorelei A, Giovannucci, Edward, Andriole, Gerald L, Cussenot, Olivier, Cancel-Tassin, Géraldine, Koutros, Stella, Beane Freeman, Laura E, Sorensen, Karina Dalsgaard, Orntoft, Torben Falck, Borre, Michael, Maehle, Lovise, Grindedal, Eli Marie, Neal, David E, Donovan, Jenny L, Hamdy, Freddie C, Martin, Richard M, Travis, Ruth C, Key, Tim J, Hamilton, Robert J, Fleshner, Neil E, Finelli, Antonio, Ingles, Sue Ann, Stern, Mariana C, Rosenstein, Barry S, Kerns, Sarah L, Ostrer, Harry, Lu, Yong-Jie, Zhang, Hong-Wei, Feng, Ninghan, Mao, Xueying, Guo, Xin, Wang, Guomin, Sun, Zan, Giles, Graham G, Southey, Melissa C, MacInnis, Robert J, FitzGerald, Liesel M, Kibel, Adam S, Drake, Bettina F, Vega, Ana, Gómez-Caamaño, Antonio, Szulkin, Robert, Eklund, Martin, Kogevinas, Manolis, Llorca, Javier, Castaño-Vinyals, Gemma, Penney, Kathryn L, Stampfer, Meir, Park, Jong Y, Sellers, Thomas A, Lin, Hui-Yi, Stanford, Janet L, and Cybulski, Cezary

Subjects
Cancer, Aging, Prostate Cancer, Genetics, Urologic Diseases, Human Genome, 2.1 Biological and endogenous factors, Aetiology, Case-Control Studies, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Humans, Male, Polymorphism, Single Nucleotide, Prostatic Neoplasms, Risk, Profile Study, Australian Prostate Cancer BioResource, IMPACT Study, Canary PASS Investigators, Breast and Prostate Cancer Cohort Consortium, PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium, Cancer of the Prostate in Sweden, Prostate Cancer Genome-wide Association Study of Uncommon Susceptibility Loci, Genetic Associations and Mechanisms in Oncology (GAME-ON)/Elucidating Loci Involved in Prostate Cancer Susceptibility (ELLIPSE) Consortium, Biological Sciences, Medical and Health Sciences, Developmental Biology
Abstract

Genome-wide association studies (GWAS) and fine-mapping efforts to date have identified more than 100 prostate cancer (PrCa)-susceptibility loci. We meta-analyzed genotype data from a custom high-density array of 46,939 PrCa cases and 27,910 controls of European ancestry with previously genotyped data of 32,255 PrCa cases and 33,202 controls of European ancestry. Our analysis identified 62 novel loci associated (P C, p.Pro1054Arg) in ATM and rs2066827 (OR = 1.06; P = 2.3 × 10-9; T>G, p.Val109Gly) in CDKN1B. The combination of all loci captured 28.4% of the PrCa familial relative risk, and a polygenic risk score conferred an elevated PrCa risk for men in the ninetieth to ninety-ninth percentiles (relative risk = 2.69; 95% confidence interval (CI): 2.55-2.82) and first percentile (relative risk = 5.71; 95% CI: 5.04-6.48) risk stratum compared with the population average. These findings improve risk prediction, enhance fine-mapping, and provide insight into the underlying biology of PrCa1.

Published
2018

11. Role of Androgen Receptor Variants in Prostate Cancer: Report from the 2017 Mission Androgen Receptor Variants Meeting.

Author

Luo, Jun, Attard, Gerhardt, Balk, Steven, Bevan, Charlotte, Burnstein, Kerry, Cato, Laura, Cherkasov, Artem, De Bono, Johann, Dong, Yan, Gao, Allen, Gleave, Martin, Heemers, Hannelore, Kanayama, Mayuko, Kittler, Ralf, Lang, Joshua, Lee, Richard, Logothetis, Christopher, Matusik, Robert, Plymate, Stephen, Sawyers, Charles, Selth, Luke, Soule, Howard, Tilley, Wayne, Weigel, Nancy, Zoubeidi, Amina, Dehm, Scott, and Raj, Ganesh

Subjects
Abiraterone, Androgen receptor variant 7, Androgen receptor variants, Castration-resistant prostate cancer, Enzalutamide, Aged, Androgen Antagonists, Androstenes, Benzamides, Biomarkers, Tumor, Congresses as Topic, Disease-Free Survival, Follow-Up Studies, Humans, Male, Middle Aged, Nitriles, Phenylthiohydantoin, Prostatic Neoplasms, Castration-Resistant, Receptors, Androgen, Risk Assessment, Survival Analysis, Treatment Outcome
Abstract

CONTEXT: Although a number of studies have demonstrated the importance of constitutively active androgen receptor variants (AR-Vs) in prostate cancer, questions still remain about the precise role of AR-Vs in the progression of castration-resistant prostate cancer (CRPC). OBJECTIVE: Key stakeholders and opinion leaders in prostate cancer convened on May 11, 2017 in Boston to establish the current state of the field of AR-Vs. EVIDENCE ACQUISITION: The meeting Mission Androgen Receptor Variants was the second of its kind sponsored by the Prostate Cancer Foundation (PCF). This invitation-only event was attended by international leaders in the field and representatives from sponsoring organizations (PCF and industry sponsors). Eighteen faculty members gave short presentations, which were followed by in-depth discussions. Discussions focused on three thematic topics: (1) potential of AR-Vs as biomarkers of therapeutic resistance; (2) role of AR-Vs as functionally active CRPC progression drivers; and (3) utility of AR-Vs as therapeutic targets in CRPC. EVIDENCE SYNTHESIS: The three meeting organizers synthesized this meeting report, which is intended to summarize major data discussed at the meeting and identify key questions as well as strategies for addressing these questions. There was a critical consensus that further study of the AR-Vs is an important research focus in CRPC. Contrasting views and emphasis, each supported by data, were presented at the meeting, discussed among the participants, and synthesized in this report. CONCLUSIONS: This article highlights the state of knowledge and outlines the most pressing questions that need to be addressed to advance the AR-V field. PATIENT SUMMARY: Although further investigation is needed to delineate the role of androgen receptor (AR) variants in metastatic castration-resistant prostate cancer, advances in measurement science have enabled development of blood-based tests for treatment selection. Detection of AR variants (eg, AR-V7) identified a patient population with poor outcomes to existing AR-targeting therapies, highlighting the need for novel therapeutic agents currently under development.

Published
2018

12. Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants

Author

Dadaev, Tokhir, Saunders, Edward J, Newcombe, Paul J, Anokian, Ezequiel, Leongamornlert, Daniel A, Brook, Mark N, Cieza-Borrella, Clara, Mijuskovic, Martina, Wakerell, Sarah, Olama, Ali Amin Al, Schumacher, Fredrick R, Berndt, Sonja I, Benlloch, Sara, Ahmed, Mahbubl, Goh, Chee, Sheng, Xin, Zhang, Zhuo, Muir, Kenneth, Govindasami, Koveela, Lophatananon, Artitaya, Stevens, Victoria L, Gapstur, Susan M, Carter, Brian D, Tangen, Catherine M, Goodman, Phyllis, Thompson, Ian M, Batra, Jyotsna, Chambers, Suzanne, Moya, Leire, Clements, Judith, Horvath, Lisa, Tilley, Wayne, Risbridger, Gail, Gronberg, Henrik, Aly, Markus, Nordström, Tobias, Pharoah, Paul, Pashayan, Nora, Schleutker, Johanna, Tammela, Teuvo LJ, Sipeky, Csilla, Auvinen, Anssi, Albanes, Demetrius, Weinstein, Stephanie, Wolk, Alicja, Hakansson, Niclas, West, Catharine, Dunning, Alison M, Burnet, Neil, Mucci, Lorelei, Giovannucci, Edward, Andriole, Gerald, Cussenot, Olivier, Cancel-Tassin, Géraldine, Koutros, Stella, Freeman, Laura E Beane, Sorensen, Karina Dalsgaard, Orntoft, Torben Falck, Borre, Michael, Maehle, Lovise, Grindedal, Eli Marie, Neal, David E, Donovan, Jenny L, Hamdy, Freddie C, Martin, Richard M, Travis, Ruth C, Key, Tim J, Hamilton, Robert J, Fleshner, Neil E, Finelli, Antonio, Ingles, Sue Ann, Stern, Mariana C, Rosenstein, Barry, Kerns, Sarah, Ostrer, Harry, Lu, Yong-Jie, Zhang, Hong-Wei, Feng, Ninghan, Mao, Xueying, Guo, Xin, Wang, Guomin, Sun, Zan, Giles, Graham G, Southey, Melissa C, MacInnis, Robert J, FitzGerald, Liesel M, Kibel, Adam S, Drake, Bettina F, Vega, Ana, Gómez-Caamaño, Antonio, Fachal, Laura, Szulkin, Robert, Eklund, Martin, Kogevinas, Manolis, Llorca, Javier, Castaño-Vinyals, Gemma, Penney, Kathryn L, Stampfer, Meir, Park, Jong Y, and Sellers, Thomas A

Subjects
Genetics, Aging, Urologic Diseases, Prostate Cancer, Prevention, Human Genome, Cancer, Clinical Research, 2.1 Biological and endogenous factors, Aetiology, Algorithms, Bayes Theorem, Black People, Chromosome Mapping, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Male, Molecular Sequence Annotation, Multivariate Analysis, Polymorphism, Single Nucleotide, Prostatic Neoplasms, Quantitative Trait Loci, Risk, White People, PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium
Abstract

Prostate cancer is a polygenic disease with a large heritable component. A number of common, low-penetrance prostate cancer risk loci have been identified through GWAS. Here we apply the Bayesian multivariate variable selection algorithm JAM to fine-map 84 prostate cancer susceptibility loci, using summary data from a large European ancestry meta-analysis. We observe evidence for multiple independent signals at 12 regions and 99 risk signals overall. Only 15 original GWAS tag SNPs remain among the catalogue of candidate variants identified; the remainder are replaced by more likely candidates. Biological annotation of our credible set of variants indicates significant enrichment within promoter and enhancer elements, and transcription factor-binding sites, including AR, ERG and FOXA1. In 40 regions at least one variant is colocalised with an eQTL in prostate cancer tissue. The refined set of candidate variants substantially increase the proportion of familial relative risk explained by these known susceptibility regions, which highlights the importance of fine-mapping studies and has implications for clinical risk profiling.

Published
2018

16. The androgen receptor is a tumor suppressor in estrogen receptor–positive breast cancer

Author

Hickey, Theresa E., Selth, Luke A., Chia, Kee Ming, Laven-Law, Geraldine, Milioli, Heloisa H., Roden, Daniel, Jindal, Shalini, Hui, Mun, Finlay-Schultz, Jessica, Ebrahimie, Esmaeil, Birrell, Stephen N., Stelloo, Suzan, Iggo, Richard, Alexandrou, Sarah, Caldon, C. Elizabeth, Abdel-Fatah, Tarek M., Ellis, Ian O., Zwart, Wilbert, Palmieri, Carlo, Sartorius, Carol A., Swarbrick, Alex, Lim, Elgene, Carroll, Jason S., and Tilley, Wayne D.

Published
2021
Full Text
View/download PDF

17. Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction

Author

Conti, David V., Darst, Burcu F., Moss, Lilit C., Saunders, Edward J., Sheng, Xin, Chou, Alisha, Schumacher, Fredrick R., Olama, Ali Amin Al, Benlloch, Sara, Dadaev, Tokhir, Brook, Mark N., Sahimi, Ali, Hoffmann, Thomas J., Takahashi, Atushi, Matsuda, Koichi, Momozawa, Yukihide, Fujita, Masashi, Muir, Kenneth, Lophatananon, Artitaya, Wan, Peggy, Le Marchand, Loic, Wilkens, Lynne R., Stevens, Victoria L., Gapstur, Susan M., Carter, Brian D., Schleutker, Johanna, Tammela, Teuvo L. J., Sipeky, Csilla, Auvinen, Anssi, Giles, Graham G., Southey, Melissa C., MacInnis, Robert J., Cybulski, Cezary, Wokołorczyk, Dominika, Lubiński, Jan, Neal, David E., Donovan, Jenny L., Hamdy, Freddie C., Martin, Richard M., Nordestgaard, Børge G., Nielsen, Sune F., Weischer, Maren, Bojesen, Stig E., Røder, Martin Andreas, Iversen, Peter, Batra, Jyotsna, Chambers, Suzanne, Moya, Leire, Horvath, Lisa, Clements, Judith A., Tilley, Wayne, Risbridger, Gail P., Gronberg, Henrik, Aly, Markus, Szulkin, Robert, Eklund, Martin, Nordström, Tobias, Pashayan, Nora, Dunning, Alison M., Ghoussaini, Maya, Travis, Ruth C., Key, Tim J., Riboli, Elio, Park, Jong Y., Sellers, Thomas A., Lin, Hui-Yi, Albanes, Demetrius, Weinstein, Stephanie J., Mucci, Lorelei A., Giovannucci, Edward, Lindstrom, Sara, Kraft, Peter, Hunter, David J., Penney, Kathryn L., Turman, Constance, Tangen, Catherine M., Goodman, Phyllis J., Thompson, Jr., Ian M., Hamilton, Robert J., Fleshner, Neil E., Finelli, Antonio, Parent, Marie-Élise, Stanford, Janet L., Ostrander, Elaine A., Geybels, Milan S., Koutros, Stella, Freeman, Laura E. Beane, Stampfer, Meir, Wolk, Alicja, Håkansson, Niclas, Andriole, Gerald L., Hoover, Robert N., Machiela, Mitchell J., Sørensen, Karina Dalsgaard, Borre, Michael, Blot, William J., Zheng, Wei, Yeboah, Edward D., Mensah, James E., Lu, Yong-Jie, Zhang, Hong-Wei, Feng, Ninghan, Mao, Xueying, Wu, Yudong, Zhao, Shan-Chao, Sun, Zan, Thibodeau, Stephen N., McDonnell, Shannon K., Schaid, Daniel J., West, Catharine M. L., Burnet, Neil, Barnett, Gill, Maier, Christiane, Schnoeller, Thomas, Luedeke, Manuel, Kibel, Adam S., Drake, Bettina F., Cussenot, Olivier, Cancel-Tassin, Géraldine, Menegaux, Florence, Truong, Thérèse, Koudou, Yves Akoli, John, Esther M., Grindedal, Eli Marie, Maehle, Lovise, Khaw, Kay-Tee, Ingles, Sue A., Stern, Mariana C., Vega, Ana, Gómez-Caamaño, Antonio, Fachal, Laura, Rosenstein, Barry S., Kerns, Sarah L., Ostrer, Harry, Teixeira, Manuel R., Paulo, Paula, Brandão, Andreia, Watya, Stephen, Lubwama, Alexander, Bensen, Jeannette T., Fontham, Elizabeth T. H., Mohler, James, Taylor, Jack A., Kogevinas, Manolis, Llorca, Javier, Castaño-Vinyals, Gemma, Cannon-Albright, Lisa, Teerlink, Craig C., Huff, Chad D., Strom, Sara S., Multigner, Luc, Blanchet, Pascal, Brureau, Laurent, Kaneva, Radka, Slavov, Chavdar, Mitev, Vanio, Leach, Robin J., Weaver, Brandi, Brenner, Hermann, Cuk, Katarina, Holleczek, Bernd, Saum, Kai-Uwe, Klein, Eric A., Hsing, Ann W., Kittles, Rick A., Murphy, Adam B., Logothetis, Christopher J., Kim, Jeri, Neuhausen, Susan L., Steele, Linda, Ding, Yuan Chun, Isaacs, William B., Nemesure, Barbara, Hennis, Anselm J. M., Carpten, John, Pandha, Hardev, Michael, Agnieszka, De Ruyck, Kim, De Meerleer, Gert, Ost, Piet, Xu, Jianfeng, Razack, Azad, Lim, Jasmine, Teo, Soo-Hwang, Newcomb, Lisa F., Lin, Daniel W., Fowke, Jay H., Neslund-Dudas, Christine, Rybicki, Benjamin A., Gamulin, Marija, Lessel, Davor, Kulis, Tomislav, Usmani, Nawaid, Singhal, Sandeep, Parliament, Matthew, Claessens, Frank, Joniau, Steven, Van den Broeck, Thomas, Gago-Dominguez, Manuela, Castelao, Jose Esteban, Martinez, Maria Elena, Larkin, Samantha, Townsend, Paul A., Aukim-Hastie, Claire, Bush, William S., Aldrich, Melinda C., Crawford, Dana C., Srivastava, Shiv, Cullen, Jennifer C., Petrovics, Gyorgy, Casey, Graham, Roobol, Monique J., Jenster, Guido, van Schaik, Ron H. N., Hu, Jennifer J., Sanderson, Maureen, Varma, Rohit, McKean-Cowdin, Roberta, Torres, Mina, Mancuso, Nicholas, Berndt, Sonja I., Van Den Eeden, Stephen K., Easton, Douglas F., Chanock, Stephen J., Cook, Michael B., Wiklund, Fredrik, Nakagawa, Hidewaki, Witte, John S., Eeles, Rosalind A., Kote-Jarai, Zsofia, and Haiman, Christopher A.

Published
2021
Full Text
View/download PDF

18. Opposing transcriptional programs of KLF5 and AR emerge during therapy for advanced prostate cancer

Author

Che, Meixia, Chaturvedi, Aashi, Munro, Sarah A., Pitzen, Samuel P., Ling, Alex, Zhang, Weijie, Mentzer, Josh, Ku, Sheng-Yu, Puca, Loredana, Zhu, Yanyun, Bergman, Andries M., Severson, Tesa M., Forster, Colleen, Liu, Yuzhen, Hildebrand, Jacob, Daniel, Mark, Wang, Ting-You, Selth, Luke A., Hickey, Theresa, Zoubeidi, Amina, Gleave, Martin, Bareja, Rohan, Sboner, Andrea, Tilley, Wayne, Carroll, Jason S., Tan, Winston, Kohli, Manish, Yang, Rendong, Hsieh, Andrew C., Murugan, Paari, Zwart, Wilbert, Beltran, Himisha, Huang, R. Stephanie, and Dehm, Scott M.

Published
2021
Full Text
View/download PDF

19. Selective inhibition of CDK9 in triple negative breast cancer

Author

Mustafa, Ebtihal H., primary, Laven-Law, Geraldine, additional, Kikhtyak, Zoya, additional, Nguyen, Van, additional, Ali, Simak, additional, Pace, Alex A., additional, Iggo, Richard, additional, Kebede, Alemwork, additional, Noll, Ben, additional, Wang, Shudong, additional, Winter, Jean M., additional, Dwyer, Amy R., additional, Tilley, Wayne D., additional, and Hickey, Theresa E., additional

Published
2023
Full Text
View/download PDF

21. Luminal breast cancer identity is determined by loss of glucocorticoid receptor activity

Author

Prekovic, Stefan, primary, Chalkiadakis, Theofilos, additional, Roest, Merel, additional, Roden, Daniel, additional, Lutz, Catrin, additional, Schuurman, Karianne, additional, Opdam, Mark, additional, Hoekman, Liesbeth, additional, Abbott, Nina, additional, Tesselaar, Tanja, additional, Wajahat, Maliha, additional, Dwyer, Amy R, additional, Mayayo‐Peralta, Isabel, additional, Gomez, Gabriela, additional, Altelaar, Maarten, additional, Beijersbergen, Roderick, additional, Győrffy, Balázs, additional, Young, Leonie, additional, Linn, Sabine, additional, Jonkers, Jos, additional, Tilley, Wayne, additional, Hickey, Theresa, additional, Vareslija, Damir, additional, Swarbrick, Alexander, additional, and Zwart, Wilbert, additional

Published
2023
Full Text
View/download PDF

24. A reciprocal feedback between the PDZ binding kinase and androgen receptor drives prostate cancer

Author

Warren, Anne Y., Massie, Charlie E., Watt, Kate, Luko, Katarina, Orafidiya, Folake, Selth, Luke A., Mohammed, Hisham, Chohan, Brinder S., Menon, Suraj, Baridi, Ajoeb, Zhao, Wanfeng, Escriu, Carles, Pungsrinont, Thanakorn, D’Santos, Clive, Yang, Xiaoping, Taylor, Chris, Qureshi, Arham, Zecchini, Vincent R., Shaw, Greg L., Dehm, Scott M., Mills, Ian G., Carroll, Jason S., Tilley, Wayne D., McEwan, Iain J., Baniahmad, Aria, Neal, David E., and Asim, Mohammad

Published
2019
Full Text
View/download PDF

30. Supplementary Figures 1-9 from Dual Roles of PARP-1 Promote Cancer Growth and Progression

Author

Schiewer, Matthew J., primary, Goodwin, Jonathan F., primary, Han, Sumin, primary, Brenner, J. Chad, primary, Augello, Michael A., primary, Dean, Jeffry L., primary, Liu, Fengzhi, primary, Planck, Jamie L., primary, Ravindranathan, Preethi, primary, Chinnaiyan, Arul M., primary, McCue, Peter, primary, Gomella, Leonard G., primary, Raj, Ganesh V., primary, Dicker, Adam P., primary, Brody, Jonathan R., primary, Pascal, John M., primary, Centenera, Margaret M., primary, Butler, Lisa M., primary, Tilley, Wayne D., primary, Feng, Felix Y., primary, and Knudsen, Karen E., primary

Published
2023
Full Text
View/download PDF

31. Data from Dual Roles of PARP-1 Promote Cancer Growth and Progression

Author

Schiewer, Matthew J., primary, Goodwin, Jonathan F., primary, Han, Sumin, primary, Brenner, J. Chad, primary, Augello, Michael A., primary, Dean, Jeffry L., primary, Liu, Fengzhi, primary, Planck, Jamie L., primary, Ravindranathan, Preethi, primary, Chinnaiyan, Arul M., primary, McCue, Peter, primary, Gomella, Leonard G., primary, Raj, Ganesh V., primary, Dicker, Adam P., primary, Brody, Jonathan R., primary, Pascal, John M., primary, Centenera, Margaret M., primary, Butler, Lisa M., primary, Tilley, Wayne D., primary, Feng, Felix Y., primary, and Knudsen, Karen E., primary

Published
2023
Full Text
View/download PDF

32. Supplementary Methods , Table 1 from Dual Roles of PARP-1 Promote Cancer Growth and Progression

Author

Schiewer, Matthew J., primary, Goodwin, Jonathan F., primary, Han, Sumin, primary, Brenner, J. Chad, primary, Augello, Michael A., primary, Dean, Jeffry L., primary, Liu, Fengzhi, primary, Planck, Jamie L., primary, Ravindranathan, Preethi, primary, Chinnaiyan, Arul M., primary, McCue, Peter, primary, Gomella, Leonard G., primary, Raj, Ganesh V., primary, Dicker, Adam P., primary, Brody, Jonathan R., primary, Pascal, John M., primary, Centenera, Margaret M., primary, Butler, Lisa M., primary, Tilley, Wayne D., primary, Feng, Felix Y., primary, and Knudsen, Karen E., primary

Published
2023
Full Text
View/download PDF

33. Data from Novel Selective Agents for the Degradation of Androgen Receptor Variants to Treat Castration-Resistant Prostate Cancer

Author

Ponnusamy, Suriyan, primary, Coss, Christopher C., primary, Thiyagarajan, Thirumagal, primary, Watts, Kate, primary, Hwang, Dong-Jin, primary, He, Yali, primary, Selth, Luke A., primary, McEwan, Iain J., primary, Duke, Charles B., primary, Pagadala, Jayaprakash, primary, Singh, Geetika, primary, Wake, Robert W., primary, Ledbetter, Christopher, primary, Tilley, Wayne D., primary, Moldoveanu, Tudor, primary, Dalton, James T., primary, Miller, Duane D., primary, and Narayanan, Ramesh, primary

Published
2023
Full Text
View/download PDF

34. Data from Lipidomic Profiling of Clinical Prostate Cancer Reveals Targetable Alterations in Membrane Lipid Composition

Author

Butler, Lisa M., primary, Mah, Chui Yan, primary, Machiels, Jelle, primary, Vincent, Andrew D., primary, Irani, Swati, primary, Mutuku, Shadrack M., primary, Spotbeen, Xander, primary, Bagadi, Muralidhararao, primary, Waltregny, David, primary, Moldovan, Max, primary, Dehairs, Jonas, primary, Vanderhoydonc, Frank, primary, Bloch, Katarzyna, primary, Das, Rajdeep, primary, Stahl, Jurgen, primary, Kench, James G., primary, Gevaert, Thomas, primary, Derua, Rita, primary, Waelkens, Etienne, primary, Nassar, Zeyad D., primary, Selth, Luke A., primary, Trim, Paul J., primary, Snel, Marten F., primary, Lynn, David J., primary, Tilley, Wayne D., primary, Horvath, Lisa G., primary, Centenera, Margaret M., primary, and Swinnen, Johannes V., primary

Published
2023
Full Text
View/download PDF

35. Figure S4: Evaluation of AR variant binding to known AREs and Snail promoters from Disrupting Androgen Receptor Signaling Induces Snail-Mediated Epithelial–Mesenchymal Plasticity in Prostate Cancer

Author

Miao, Lu, primary, Yang, Lin, primary, Li, Rui, primary, Rodrigues, Daniel N., primary, Crespo, Mateus, primary, Hsieh, Jer-Tsong, primary, Tilley, Wayne D., primary, de Bono, Johann, primary, Selth, Luke A., primary, and Raj, Ganesh V., primary

Published
2023
Full Text
View/download PDF

36. Figure S2: Effect of treatment protocol on migration in PC3 and PC-3(AR)2 cells from Disrupting Androgen Receptor Signaling Induces Snail-Mediated Epithelial–Mesenchymal Plasticity in Prostate Cancer

Author

Miao, Lu, primary, Yang, Lin, primary, Li, Rui, primary, Rodrigues, Daniel N., primary, Crespo, Mateus, primary, Hsieh, Jer-Tsong, primary, Tilley, Wayne D., primary, de Bono, Johann, primary, Selth, Luke A., primary, and Raj, Ganesh V., primary

Published
2023
Full Text
View/download PDF

37. Data from Global Levels of Specific Histone Modifications and an Epigenetic Gene Signature Predict Prostate Cancer Progression and Development

Author

Bianco-Miotto, Tina, primary, Chiam, Karen, primary, Buchanan, Grant, primary, Jindal, Shalini, primary, Day, Tanya K., primary, Thomas, Mervyn, primary, Pickering, Marie A., primary, O'Loughlin, Melissa A., primary, Ryan, Natalie K., primary, Raymond, Wendy A., primary, Horvath, Lisa G., primary, Kench, James G., primary, Stricker, Phillip D., primary, Marshall, Villis R., primary, Sutherland, Robert L., primary, Henshall, Susan M., primary, Gerald, William L., primary, Scher, Howard I., primary, Risbridger, Gail P., primary, Clements, Judith A., primary, Butler, Lisa M., primary, Tilley, Wayne D., primary, Horsfall, David J., primary, and Ricciardelli, Carmela, primary

Published
2023
Full Text
View/download PDF

38. Data from The Magnitude of Androgen Receptor Positivity in Breast Cancer Is Critical for Reliable Prediction of Disease Outcome

Author

Ricciardelli, Carmela, primary, Bianco-Miotto, Tina, primary, Jindal, Shalini, primary, Butler, Lisa M., primary, Leung, Samuel, primary, McNeil, Catriona M., primary, O'Toole, Sandra A., primary, Ebrahimie, Esmaeil, primary, Millar, Ewan K.A., primary, Sakko, Andrew J., primary, Ruiz, Alexandra I., primary, Vowler, Sarah L., primary, Huntsman, David G., primary, Birrell, Stephen N., primary, Sutherland, Robert L., primary, Palmieri, Carlo, primary, Hickey, Theresa E., primary, and Tilley, Wayne D., primary

Published
2023
Full Text
View/download PDF

39. Supplementary Figure Legends from Androgen and Estrogen Receptors in Breast Cancer Coregulate Human UDP-Glucuronosyltransferases 2B15 and 2B17

Author

Hu, Dong G., primary, Selth, Luke A., primary, Tarulli, Gerard A., primary, Meech, Robyn, primary, Wijayakumara, Dhilushi, primary, Chanawong, Apichaya, primary, Russell, Roslin, primary, Caldas, Carlos, primary, Robinson, Jessica L.L., primary, Carroll, Jason S., primary, Tilley, Wayne D., primary, Mackenzie, Peter I., primary, and Hickey, Theresa E., primary

Published
2023
Full Text
View/download PDF

40. Supplementary Figure 1 from Global Levels of Specific Histone Modifications and an Epigenetic Gene Signature Predict Prostate Cancer Progression and Development

Author

Bianco-Miotto, Tina, primary, Chiam, Karen, primary, Buchanan, Grant, primary, Jindal, Shalini, primary, Day, Tanya K., primary, Thomas, Mervyn, primary, Pickering, Marie A., primary, O'Loughlin, Melissa A., primary, Ryan, Natalie K., primary, Raymond, Wendy A., primary, Horvath, Lisa G., primary, Kench, James G., primary, Stricker, Phillip D., primary, Marshall, Villis R., primary, Sutherland, Robert L., primary, Henshall, Susan M., primary, Gerald, William L., primary, Scher, Howard I., primary, Risbridger, Gail P., primary, Clements, Judith A., primary, Butler, Lisa M., primary, Tilley, Wayne D., primary, Horsfall, David J., primary, and Ricciardelli, Carmela, primary

Published
2023
Full Text
View/download PDF

41. Supplementary Materials and Methods from Androgen and Estrogen Receptors in Breast Cancer Coregulate Human UDP-Glucuronosyltransferases 2B15 and 2B17

Author

Hu, Dong G., primary, Selth, Luke A., primary, Tarulli, Gerard A., primary, Meech, Robyn, primary, Wijayakumara, Dhilushi, primary, Chanawong, Apichaya, primary, Russell, Roslin, primary, Caldas, Carlos, primary, Robinson, Jessica L.L., primary, Carroll, Jason S., primary, Tilley, Wayne D., primary, Mackenzie, Peter I., primary, and Hickey, Theresa E., primary

Published
2023
Full Text
View/download PDF

42. Supplementary Figure 3 from Global Levels of Specific Histone Modifications and an Epigenetic Gene Signature Predict Prostate Cancer Progression and Development

Author

Bianco-Miotto, Tina, primary, Chiam, Karen, primary, Buchanan, Grant, primary, Jindal, Shalini, primary, Day, Tanya K., primary, Thomas, Mervyn, primary, Pickering, Marie A., primary, O'Loughlin, Melissa A., primary, Ryan, Natalie K., primary, Raymond, Wendy A., primary, Horvath, Lisa G., primary, Kench, James G., primary, Stricker, Phillip D., primary, Marshall, Villis R., primary, Sutherland, Robert L., primary, Henshall, Susan M., primary, Gerald, William L., primary, Scher, Howard I., primary, Risbridger, Gail P., primary, Clements, Judith A., primary, Butler, Lisa M., primary, Tilley, Wayne D., primary, Horsfall, David J., primary, and Ricciardelli, Carmela, primary

Published
2023
Full Text
View/download PDF

44. Supplementary data from MicroRNA-194 Promotes Prostate Cancer Metastasis by Inhibiting SOCS2

Author

Das, Rajdeep, primary, Gregory, Philip A., primary, Fernandes, Rayzel C., primary, Denis, Iza, primary, Wang, Qingqing, primary, Townley, Scott L., primary, Zhao, Shuang G., primary, Hanson, Adrienne R., primary, Pickering, Marie A., primary, Armstrong, Heather K., primary, Lokman, Noor A., primary, Ebrahimie, Esmaeil, primary, Davicioni, Elai, primary, Jenkins, Robert B., primary, Karnes, R. Jeffrey, primary, Ross, Ashley E., primary, Den, Robert B., primary, Klein, Eric A., primary, Chi, Kim N., primary, Ramshaw, Hayley S., primary, Williams, Elizabeth D., primary, Zoubeidi, Amina, primary, Goodall, Gregory J., primary, Feng, Felix Y., primary, Butler, Lisa M., primary, Tilley, Wayne D., primary, and Selth, Luke A., primary

Published
2023
Full Text
View/download PDF

45. Supplementary Figure 2 from Global Levels of Specific Histone Modifications and an Epigenetic Gene Signature Predict Prostate Cancer Progression and Development

Author

Bianco-Miotto, Tina, primary, Chiam, Karen, primary, Buchanan, Grant, primary, Jindal, Shalini, primary, Day, Tanya K., primary, Thomas, Mervyn, primary, Pickering, Marie A., primary, O'Loughlin, Melissa A., primary, Ryan, Natalie K., primary, Raymond, Wendy A., primary, Horvath, Lisa G., primary, Kench, James G., primary, Stricker, Phillip D., primary, Marshall, Villis R., primary, Sutherland, Robert L., primary, Henshall, Susan M., primary, Gerald, William L., primary, Scher, Howard I., primary, Risbridger, Gail P., primary, Clements, Judith A., primary, Butler, Lisa M., primary, Tilley, Wayne D., primary, Horsfall, David J., primary, and Ricciardelli, Carmela, primary

Published
2023
Full Text
View/download PDF

46. Supplementary Figure 3 from Evidence for Efficacy of New Hsp90 Inhibitors Revealed by Ex Vivo Culture of Human Prostate Tumors

Author

Centenera, Margaret M., primary, Gillis, Joanna L., primary, Hanson, Adrienne R., primary, Jindal, Shalini, primary, Taylor, Renea A., primary, Risbridger, Gail P., primary, Sutherland, Peter D., primary, Scher, Howard I., primary, Raj, Ganesh V., primary, Knudsen, Karen E., primary, Yeadon, Trina, primary, Tilley, Wayne D., primary, and Butler, Lisa M., primary

Published
2023
Full Text
View/download PDF

47. Supplementary Figure 5 from Global Levels of Specific Histone Modifications and an Epigenetic Gene Signature Predict Prostate Cancer Progression and Development

Author

Bianco-Miotto, Tina, primary, Chiam, Karen, primary, Buchanan, Grant, primary, Jindal, Shalini, primary, Day, Tanya K., primary, Thomas, Mervyn, primary, Pickering, Marie A., primary, O'Loughlin, Melissa A., primary, Ryan, Natalie K., primary, Raymond, Wendy A., primary, Horvath, Lisa G., primary, Kench, James G., primary, Stricker, Phillip D., primary, Marshall, Villis R., primary, Sutherland, Robert L., primary, Henshall, Susan M., primary, Gerald, William L., primary, Scher, Howard I., primary, Risbridger, Gail P., primary, Clements, Judith A., primary, Butler, Lisa M., primary, Tilley, Wayne D., primary, Horsfall, David J., primary, and Ricciardelli, Carmela, primary

Published
2023
Full Text
View/download PDF

48. Supplementary Figure 2 from Evidence for Efficacy of New Hsp90 Inhibitors Revealed by Ex Vivo Culture of Human Prostate Tumors

Author

Centenera, Margaret M., primary, Gillis, Joanna L., primary, Hanson, Adrienne R., primary, Jindal, Shalini, primary, Taylor, Renea A., primary, Risbridger, Gail P., primary, Sutherland, Peter D., primary, Scher, Howard I., primary, Raj, Ganesh V., primary, Knudsen, Karen E., primary, Yeadon, Trina, primary, Tilley, Wayne D., primary, and Butler, Lisa M., primary

Published
2023
Full Text
View/download PDF

49. Supplementary Table 2 from Comparative Biomarker Expression and RNA Integrity in Biospecimens Derived from Radical Retropubic and Robot-Assisted Laparoscopic Prostatectomies

Author

Ricciardelli, Carmela, primary, Bianco-Miotto, Tina, primary, Jindal, Shalini, primary, Dodd, Thomas J., primary, Cohen, Penelope A., primary, Marshall, Villis R., primary, Sutherland, Peter D., primary, Samaratunga, Hemamali, primary, Kench, James G., primary, Dong, Ying, primary, Wang, Hong, primary, Clements, Judith A., primary, Risbridger, Gail P., primary, Sutherland, Robert L., primary, Tilley, Wayne D., primary, and Horsfall, David J., primary

Published
2023
Full Text
View/download PDF

50. Supplementary Table 2 from Global Levels of Specific Histone Modifications and an Epigenetic Gene Signature Predict Prostate Cancer Progression and Development

Author

Bianco-Miotto, Tina, primary, Chiam, Karen, primary, Buchanan, Grant, primary, Jindal, Shalini, primary, Day, Tanya K., primary, Thomas, Mervyn, primary, Pickering, Marie A., primary, O'Loughlin, Melissa A., primary, Ryan, Natalie K., primary, Raymond, Wendy A., primary, Horvath, Lisa G., primary, Kench, James G., primary, Stricker, Phillip D., primary, Marshall, Villis R., primary, Sutherland, Robert L., primary, Henshall, Susan M., primary, Gerald, William L., primary, Scher, Howard I., primary, Risbridger, Gail P., primary, Clements, Judith A., primary, Butler, Lisa M., primary, Tilley, Wayne D., primary, Horsfall, David J., primary, and Ricciardelli, Carmela, primary

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results