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This article presents topical issues devoted to the study and prospects for the development of enzyme preparations in modern pharmaceutical practice in the Republic of Uzbekistan. In the context of existing resources, the rational use of high-quality, effective, safe medicines and the creation of new ones by combining local raw materials with an innovative approach is a priority. The expediency of combinations of drugs useful for medical practice for effort or combination of effects is noted. In medicine, nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used to treat rheumatoid arthritis and other inflammatory diseases. NSAIDs are the basic drugs in the pharmacotherapy of many chronic, acute diseases, normalizing biochemical parameters and the functional state of blood cells. These drugs are taken over-the-counter and for a long time, and therefore resolving issues, related to the safety of their use, the search for a combination is relevant. Currently, domestic developments of NSAIDs (fensulkal, blizketazin) are being carried out by combining enzymes (to enhance the effect) and in justified rectal and transfermal medicinal forms. Many diseases are associated with impaired secondary enzyme deficiency. Clinical studies confirm the high effectiveness of the combination of NSAIDs with enzyme preparations. The classification of proteolytic enzymes, the importance, scale and resources of the prevalence of plant enzymes in the Republic are presented. Of particular interest is the papaya (melon tree). Papain and chymopapain are latex enzymes of the fruits of the melon tree. [ABSTRACT FROM AUTHOR]

Polysaccharides, the most abundant biopolymers in nature, have attracted the attention of researchers and clinicians due to its practicality in biomedical and pharmaceutical sciences. These biomaterials have high bioavailability and play structural and functional roles in living organisms. Polysaccharides are classified into several groups based on their origin, including plant polysaccharides and marine polysaccharides (like chitosan, hyaluronic acid, dextran, alginates, etc.) with specific applications. These biopolymers possess unique physicochemical (such as surface functional groups, solubility, and stability), mechanical (like mechanical strength and tensile), and biomedical (such as antioxidant activity, biocompatibility, biodegradability, renewability, and non-immunogenicity) characteristics which have made them excellent platforms for a wide variety of biomedical and pharmaceutical applications. Ease of extraction and different preparation approaches are mentioned as other potential properties of polysaccharides that further improved their practicality in biomedical sciences. They have high drug/bioactive encapsulation capacity and sustained/controlled release manner in in vivo microenvironments. The anti-inflammatory and immunomodulation, stimuli-responsive drug/bioactive release, and passive and active drug/bioactive delivery are considered the potential features of these biopolymers in pharmaceutical sciences. Polysaccharides have indicated practical applications in biomedical sciences, including biosensors, tissue engineering, implantation, wound healing, vascular grafting, and vaccines. This review highlights the advances of polysaccharide-based materials in biomedical and pharmaceutical sciences., (© 2024 Deutsche Pharmazeutische Gesellschaft.)