19 results on '"Tilakaratne, D"'
Search Results
2. A RARE CAUSE OF UNILATERAL BRONCHIECTASIS: SWYER-JAMES-MACLEOD SYNDROME
- Author
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MALINDA, S., primary, TILAKARATNE, D., additional, DAHANAYAKE, C., additional, GANEARACHCHI, I., additional, and PERERA, E., additional
- Published
- 2022
- Full Text
- View/download PDF
3. Molecular diagnosis of scabies using a novel probe-based polymerase chain reaction assay targeting high-copy number repetitive sequences in the Sarcoptes scabiei genome
- Author
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Bradbury, RS, Chng, L, Holt, DC, Field, M, Francis, JR, Tilakaratne, D, Dekkers, MH, Robinson, G, Mounsey, K, Pavlos, R, Bowen, AC, Fischer, K, Papenfuss, AT, Gasser, RB, Korhonen, PK, Currie, BJ, McCarthy, JS, Pasay, C, Bradbury, RS, Chng, L, Holt, DC, Field, M, Francis, JR, Tilakaratne, D, Dekkers, MH, Robinson, G, Mounsey, K, Pavlos, R, Bowen, AC, Fischer, K, Papenfuss, AT, Gasser, RB, Korhonen, PK, Currie, BJ, McCarthy, JS, and Pasay, C
- Abstract
BACKGROUND: The suboptimal sensitivity and specificity of available diagnostic methods for scabies hampers clinical management, trials of new therapies and epidemiologic studies. Additionally, parasitologic diagnosis by microscopic examination of skin scrapings requires sample collection with a sharp scalpel blade, causing discomfort to patients and difficulty in children. Polymerase chain reaction (PCR)-based diagnostic assays, combined with non-invasive sampling methods, represent an attractive approach. In this study, we aimed to develop a real-time probe-based PCR test for scabies, test a non-invasive sampling method and evaluate its diagnostic performance in two clinical settings. METHODOLOGY/PRINCIPAL FINDINGS: High copy-number repetitive DNA elements were identified in draft Sarcoptes scabiei genome sequences and used as assay targets for diagnostic PCR. Two suitable repetitive DNA sequences, a 375 base pair microsatellite (SSR5) and a 606 base pair long tandem repeat (SSR6), were identified. Diagnostic sensitivity and specificity were tested using relevant positive and negative control materials and compared to a published assay targeting the mitochondrial cox1 gene. Both assays were positive at a 1:100 dilution of DNA from a single mite; no amplification was observed in DNA from samples from 19 patients with other skin conditions nor from house dust, sheep or dog mites, head and body lice or from six common skin bacterial and fungal species. Moderate sensitivity of the assays was achieved in a pilot study, detecting 5/7 (71.4% [95% CI: 29.0% - 96.3%]) of clinically diagnosed untreated scabies patients). Greater sensitivity was observed in samples collected by FLOQ swabs compared to skin scrapings. CONCLUSIONS/SIGNIFICANCE: This newly developed qPCR assay, combined with the use of an alternative non-invasive swab sampling technique offers the possibility of enhanced diagnosis of scabies. Further studies will be required to better define the diagnostic perfor
- Published
- 2021
4. The 2020 IACS Consensus Criteria for the Diagnosis of Scabies
- Author
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Engelman, D, Yoshizumi, J, Hay, R J, Osti, M, Micali, G, Norton, S, Walton, S, Boralevi, F, Bernigaud, C, Bowen, A C, Chang, A Y, Chosidow, O, Estrada-Chavez, G, Feldmeier, H, Ishii, N, Lacarrubba, F, Mahé, A, Maurer, T, Mahdi, M M A, Murdoch, M E, Pariser, D, Nair, P A, Rehmus, W, Romani, L, Tilakaratne, D, Tuicakau, M, Walker, S L, Wanat, K A, Whitfeld, M J, Yotsu, R R, Steer, A C, and Fuller, C
- Published
- 2020
5. The 2020 International Alliance for the Control of Scabies Consensus Criteria for the Diagnosis of Scabies
- Author
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Engelman, D, Yoshizumi, J, Hay, RJ, Osti, M, Micali, G, Norton, S, Walton, S, Boralevi, F, Bernigaud, C, Bowen, AC, Chang, AY, Chosidow, O, Estrada-Chavez, G, Feldmeier, H, Ishii, N, Lacarrubba, F, Mahe, A, Maurer, T, Mahdi, MMA, Murdoch, ME, Pariser, D, Nair, PA, Rehmus, W, Romani, L, Tilakaratne, D, Tuicakau, M, Walker, SL, Wanat, KA, Whitfeld, MJ, Yotsu, RR, Steer, AC, Fuller, LC, Engelman, D, Yoshizumi, J, Hay, RJ, Osti, M, Micali, G, Norton, S, Walton, S, Boralevi, F, Bernigaud, C, Bowen, AC, Chang, AY, Chosidow, O, Estrada-Chavez, G, Feldmeier, H, Ishii, N, Lacarrubba, F, Mahe, A, Maurer, T, Mahdi, MMA, Murdoch, ME, Pariser, D, Nair, PA, Rehmus, W, Romani, L, Tilakaratne, D, Tuicakau, M, Walker, SL, Wanat, KA, Whitfeld, MJ, Yotsu, RR, Steer, AC, and Fuller, LC
- Abstract
BACKGROUND: Scabies is a common parasitic skin condition that causes considerable morbidity globally. Clinical and epidemiological research for scabies has been limited by a lack of standardization of diagnostic methods. OBJECTIVES: To develop consensus criteria for the diagnosis of common scabies that could be implemented in a variety of settings. METHODS: Consensus diagnostic criteria were developed through a Delphi study with international experts. Detailed recommendations were collected from the expert panel to define the criteria features and guide their implementation. These comments were then combined with a comprehensive review of the available literature and the opinion of an expanded group of international experts to develop detailed, evidence-based definitions and diagnostic methods. RESULTS: The 2020 International Alliance for the Control of Scabies (IACS) Consensus Criteria for the Diagnosis of Scabies include three levels of diagnostic certainty and eight subcategories. Confirmed scabies (level A) requires direct visualization of the mite or its products. Clinical scabies (level B) and suspected scabies (level C) rely on clinical assessment of signs and symptoms. Evidence-based, consensus methods for microscopy, visualization and clinical symptoms and signs were developed, along with a media library. CONCLUSIONS: The 2020 IACS Criteria represent a pragmatic yet robust set of diagnostic features and methods. The criteria may be implemented in a range of research, public health and clinical settings by selecting the appropriate diagnostic levels and subcategories. These criteria may provide greater consistency and standardization for scabies diagnosis. Validation studies, development of training materials and development of survey methods are now required. What is already known about this topic? The diagnosis of scabies is limited by the lack of accurate, objective tests. Microscopy of skin scrapings can confirm the diagnosis, but it is insensitive, inva
- Published
- 2020
6. The 2020 International Alliance for the Control of Scabies Consensus Criteria for the Diagnosis of Scabies
- Author
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Engelman, D., primary, Yoshizumi, J., additional, Hay, R.J., additional, Osti, M., additional, Micali, G., additional, Norton, S., additional, Walton, S., additional, Boralevi, F., additional, Bernigaud, C., additional, Bowen, A.C., additional, Chang, A.Y., additional, Chosidow, O., additional, Estrada‐Chavez, G., additional, Feldmeier, H., additional, Ishii, N., additional, Lacarrubba, F., additional, Mahé, A., additional, Maurer, T., additional, Mahdi, M.M.A., additional, Murdoch, M.E., additional, Pariser, D., additional, Nair, P.A., additional, Rehmus, W., additional, Romani, L., additional, Tilakaratne, D., additional, Tuicakau, M., additional, Walker, S.L., additional, Wanat, K.A., additional, Whitfeld, M.J., additional, Yotsu, R.R., additional, Steer, A.C., additional, and Fuller, L.C., additional
- Published
- 2020
- Full Text
- View/download PDF
7. The utilization pattern of surgical lung biopsies (SLB) for the diagnosis of interstitial lung diseases (ILD) in Sri Lanka
- Author
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Rathnapala, Amila, primary, Wickramasinghe, S, additional, Tilakaratne, D, additional, Chreif, H, additional, Palihawadana, S, additional, Handagala, D, additional, Perera, E, additional, Kularatne, S, additional, Gunasena, B, additional, and Punchihewa, R, additional
- Published
- 2019
- Full Text
- View/download PDF
8. Tuberculosis reactivation following apremilast therapy for psoriasis: Time to consider routine TB screening?
- Author
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Adams L, Smith EL, Tilakaratne D, and Krause V
- Abstract
Apremilast is a relatively new oral treatment for psoriasis, which reduces expression of pro-inflammatory factors, including tumour necrosis factor-α (TNFα), critical to the immune control of Mycobacterium tuberculosis infection. In randomised controlled trials (RCTs) for apremilast no new cases of active tuberculosis (TB) were identified, thus, screening for latent TB infection (LTBI) is not currently recommended prior to apremilast initiation. We describe a case of M.tuberculosis reactivation shortly after commencement of apremilast for psoriasis. We are recommending clinicians perform LTBI risk assessment in all patients, and appropriate LTBI screening in select populations prior to apremilast initiation., (© 2024 The Australasian College of Dermatologists.)
- Published
- 2024
- Full Text
- View/download PDF
9. Australian consensus: Treatment goals for moderate to severe psoriasis in the era of targeted therapies - Adult patients.
- Author
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Foley P, Gebauer K, Sullivan J, McMeniman E, Shumack S, Ng J, James A, Rawlin M, Sidhu S, Tilakaratne D, Turner M, Radulski B, Nash P, and Baker C
- Subjects
- Humans, Adult, Goals, Australia, Treatment Outcome, Delphi Technique, Quality of Life, Psoriasis drug therapy
- Abstract
Background: Over the last decade, the treatment landscape for moderate-severe psoriasis has rapidly evolved. The Australasian College of Dermatologists sought to review and update previously published treatment goals for moderate-severe psoriasis., Methods: A modified Delphi approach was used. Comprehensive literature review and guideline evaluation resulted in the development of statements and other questions to establish current clinical practices. Two rounds of anonymous voting were undertaken, with a collaborative meeting held in between to discuss areas of discordance. Overall, consensus was defined as achievement of ≥75% agreement in the range 7-9 on a 9-point scale (1 strongly disagree; 9 strongly agree)., Results: Consensus was achieved on 26/29 statements in round 1 and a further 20 statements in round 2. There was strong agreement to expanding the classification/definition of psoriasis severity by including a choice of metrics, incorporating quality of life measures, and widening the scope of high-impact sites. Consensus was also reached on revised treatment response criteria, which were then incorporated into a new treatment algorithm. There was discordance with the current requirement to undertake a trial with established systemic agents before accessing targeted therapy., Conclusion: The ability of new targeted treatment options to change the narrative in psoriasis patient care can only be properly realised if challenges to timely and equitable access are addressed. The proposed framework for the assessment, classification and management of moderate-severe psoriasis aligns with international recommendations. Its adoption into Australian clinical practice is hoped to improve treatment outcomes and patients' satisfaction with their care., (© 2023 The Authors. Australasian Journal of Dermatology published by John Wiley & Sons Australia, Ltd on behalf of Australasian College of Dermatologists.)
- Published
- 2023
- Full Text
- View/download PDF
10. Dermatological services; patient profiling in a rural tertiary hospital.
- Author
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Thomas L, Felmingham C, and Tilakaratne D
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Cohort Studies, Female, Humans, Indigenous Peoples, Infant, Male, Middle Aged, Northern Territory, Retrospective Studies, Rural Population, Tertiary Care Centers, Young Adult, Ambulatory Care statistics & numerical data, Appointments and Schedules, Dermatology statistics & numerical data, Rural Health Services statistics & numerical data
- Abstract
Background/objectives: There is a paucity of research available regarding the epidemiology of patients attending dermatology outpatient services in Australia. Our objective was to analyse who was attending public dermatology outpatient clinics in a Northern Territory tertiary hospital, with a particular focus on Indigenous and rural patients., Methods: This is a retrospective cohort study of patients who attended dermatology outpatient clinics between 1 January 2016 and 31 December 2016. Outcome measures included patient demographics (age, gender, ethnicity and postcode) and referrer details., Results: Over the 12 month study period, 923 appointments were scheduled for 500 patients. Of the appointments scheduled, 667 were attended. Twelve per cent of patients were Indigenous, and of the total appointment attendances, 10% were by Indigenous patients. Of the 923 appointments, 28% were not attended, with a higher non-attendance rate for Indigenous patients at 36%. The majority of patients seen were adults, for both groups, but a larger proportion of Indigenous children were seen. Nine per cent of patients with a recorded address were from a remote region., Conclusion: Dermatology outpatient services are likely under-utilised by Indigenous, and remote patients. If we are to improve skin health in Australia, barriers such as limited access to dermatological services in remote regions must be addressed., (© 2021 The Australasian College of Dermatologists.)
- Published
- 2021
- Full Text
- View/download PDF
11. Molecular diagnosis of scabies using a novel probe-based polymerase chain reaction assay targeting high-copy number repetitive sequences in the Sarcoptes scabiei genome.
- Author
-
Chng L, Holt DC, Field M, Francis JR, Tilakaratne D, Dekkers MH, Robinson G, Mounsey K, Pavlos R, Bowen AC, Fischer K, Papenfuss AT, Gasser RB, Korhonen PK, Currie BJ, McCarthy JS, and Pasay C
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Animals, Child, Cyclooxygenase 1 genetics, Female, Humans, Infant, Male, Middle Aged, Pilot Projects, Prospective Studies, Real-Time Polymerase Chain Reaction, Repetitive Sequences, Nucleic Acid, Sensitivity and Specificity, Sheep, Skin, Specimen Handling, DNA Copy Number Variations, Genome, Molecular Diagnostic Techniques methods, Sarcoptes scabiei genetics, Scabies diagnosis, Scabies parasitology
- Abstract
Background: The suboptimal sensitivity and specificity of available diagnostic methods for scabies hampers clinical management, trials of new therapies and epidemiologic studies. Additionally, parasitologic diagnosis by microscopic examination of skin scrapings requires sample collection with a sharp scalpel blade, causing discomfort to patients and difficulty in children. Polymerase chain reaction (PCR)-based diagnostic assays, combined with non-invasive sampling methods, represent an attractive approach. In this study, we aimed to develop a real-time probe-based PCR test for scabies, test a non-invasive sampling method and evaluate its diagnostic performance in two clinical settings., Methodology/principal Findings: High copy-number repetitive DNA elements were identified in draft Sarcoptes scabiei genome sequences and used as assay targets for diagnostic PCR. Two suitable repetitive DNA sequences, a 375 base pair microsatellite (SSR5) and a 606 base pair long tandem repeat (SSR6), were identified. Diagnostic sensitivity and specificity were tested using relevant positive and negative control materials and compared to a published assay targeting the mitochondrial cox1 gene. Both assays were positive at a 1:100 dilution of DNA from a single mite; no amplification was observed in DNA from samples from 19 patients with other skin conditions nor from house dust, sheep or dog mites, head and body lice or from six common skin bacterial and fungal species. Moderate sensitivity of the assays was achieved in a pilot study, detecting 5/7 (71.4% [95% CI: 29.0% - 96.3%]) of clinically diagnosed untreated scabies patients). Greater sensitivity was observed in samples collected by FLOQ swabs compared to skin scrapings., Conclusions/significance: This newly developed qPCR assay, combined with the use of an alternative non-invasive swab sampling technique offers the possibility of enhanced diagnosis of scabies. Further studies will be required to better define the diagnostic performance of these tests., Competing Interests: The authors have declared that no competing interests exist.
- Published
- 2021
- Full Text
- View/download PDF
12. Comparison of Cutaneous Lupus Erythematosus in Indigenous and Non-Indigenous Patients at a Regional Centre in Australia.
- Author
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Thomas L, Howarth T, and Tilakaratne D
- Subjects
- Adult, Australia, Female, Humans, Male, Middle Aged, Retrospective Studies, Lupus Erythematosus, Cutaneous ethnology, Lupus Erythematosus, Cutaneous pathology, Native Hawaiian or Other Pacific Islander statistics & numerical data
- Published
- 2020
- Full Text
- View/download PDF
13. Overdiagnosis of scabies and overprescribing of scabies treatment in a scabies-endemic region.
- Author
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Felmingham C and Tilakaratne D
- Subjects
- Adult, Ambulatory Care statistics & numerical data, Drug Administration Schedule, Female, Humans, Male, Practice Guidelines as Topic, Retrospective Studies, Inappropriate Prescribing statistics & numerical data, Insecticides therapeutic use, Medical Overuse statistics & numerical data, Scabies diagnosis, Scabies drug therapy
- Abstract
Objective: To assess the objective evidence upon which diagnosis of scabies and subsequent prescription of permethrin cream or oral ivermectin is based at a tertiary referral hospital in the Northern Territory., Design, Setting and Participants: A retrospective cohort study of inpatients who were prescribed permethrin or ivermectin between July and September 2017 at a single tertiary referral hospital. Eighty-eight inpatient admissions, belonging to 77 unique patients, were included. This list was generated with the hospital's electronic prescribing software., Main Outcome Measures: Age, ethnicity, skin diagnosis on admission, which anti-scabies medications were prescribed, which concurrent medications were prescribed to treat a rash or pruritus, which differential or concurrent skin diagnoses were made, whether the dermatology department had seen the patient during their admission, and what evidence was documented as reason for diagnosis of scabies., Results: In the cases in which scabies treatment was prescribed, less than one quarter had positive skin scrapings for scabies, and few had documentation of burrows, and documentation of a contact history combined with clinical lesions. Most cases met none of these diagnostic criteria. Very few were reviewed by the dermatology department as an inpatient., Conclusions: There were likely high rates of diagnostic uncertainty among the cases in which scabies treatment was prescribed. It is possible that anti-scabies medications are being prescribed empirically in this hospital., (© 2020 National Rural Health Alliance Ltd.)
- Published
- 2020
- Full Text
- View/download PDF
14. A follow-up of sunscreen use and sun-protection practices in Darwin: a cross-sectional survey.
- Author
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Ma JHY, Chatfield MD, Campbell K, and Tilakaratne D
- Subjects
- Adolescent, Adult, Aged, Australia epidemiology, Child, Child, Preschool, Cross-Sectional Studies, Female, Humans, Male, Northern Territory epidemiology, Sunburn epidemiology, Sunscreening Agents therapeutic use, Surveys and Questionnaires, Skin Neoplasms prevention & control, Sunburn prevention & control, Sunlight adverse effects, Sunscreening Agents administration & dosage
- Published
- 2019
- Full Text
- View/download PDF
15. Neonatal tinea corporis.
- Author
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Warren LJ, Tilakaratne D, and Seth R
- Subjects
- Antifungal Agents administration & dosage, Humans, Infant Care methods, Infant, Newborn, Male, Tinea drug therapy, Infectious Disease Transmission, Vertical, Tinea diagnosis, Tinea transmission, Trichophyton isolation & purification
- Published
- 2017
- Full Text
- View/download PDF
16. Concurrent pyoderma gangrenosum and infection with Scedosporium apiospermum.
- Author
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Tilakaratne D, Ryan E, and Pearce A
- Subjects
- Aged, 80 and over, Arthroplasty, Replacement, Hip adverse effects, Dermatomycoses drug therapy, Dermatomycoses microbiology, Female, Humans, Pyoderma Gangrenosum drug therapy, Recurrence, Dermatomycoses complications, Leg Ulcer etiology, Pyoderma Gangrenosum complications, Scedosporium
- Abstract
We present a patient with pyoderma gangrenosum (PG) following hip surgery, who developed an exacerbation of her ulceration in conjunction with new areas on her lower limbs. Clinically, features of PG and deep fungal infection were apparent. Scedosporium apiospermum was isolated from the ulcers., (© 2015 The Australasian College of Dermatologists.)
- Published
- 2016
- Full Text
- View/download PDF
17. A casemix study of patients seen by a dermatology trainee in rural and urban outpatient settings.
- Author
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Tilakaratne D, Warren L, and Menz J
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Ambulatory Care statistics & numerical data, Child, Child, Preschool, Dermatology statistics & numerical data, Female, Humans, Infant, Infant, Newborn, Male, Middle Aged, Northern Territory, Prospective Studies, South Australia, Young Adult, Dermatology education, Rural Health Services statistics & numerical data, Skin Diseases diagnosis, Skin Diseases therapy, Urban Health Services statistics & numerical data
- Abstract
Background/objectives: For 8 years South Australian dermatologists have provided an outreach service to the Northern Territory (NT), including rural and remote areas. In 2012 and 2013, a trainee accompanied a dermatologist on these outreach visits. This is the first prospective study that documents the spectrum of dermatological diseases requiring outpatient specialist input in various settings in the NT, and also the first study to compare the clinical experience of one Australian dermatology trainee in urban and rural settings., Materials and Methods: Characteristics of patients managed primarily by the outreach dermatology registrar were recorded prospectively from February 2013 to July 2013. The data from the trainee's urban encounters were compared to that of the rural centres. The spectrum of conditions seen in these two settings was placed in the disease categories specified in the Australasian College of Dermatologists (ACD) curriculum., Results: The Royal Adelaide Hospital outpatient experience provided greater exposure to skin neoplasms, lymphoproliferative and myeloproliferative disorders and non-infectious neutrophilic/eosinophilic disorders. The outreach sites provided greater exposure to infections, adnexal diseases and genodermatoses. Both urban and rural experiences provided a broad exposure to the disease categories outlined in the ACD curriculum., Conclusions: The spectrum of disease requiring specialist dermatology input varies between urban South Australia and rural NT. The inclusion of dermatology trainees in outreach visits broadens their clinical exposure. It is recommended that other dermatology service providers in Australia consider documenting clinical casemix comparisons to assess dermatology demand, outcomes and trainee exposure., (© 2014 The Australasian College of Dermatologists.)
- Published
- 2016
- Full Text
- View/download PDF
18. Heavy metal (monoclonal) bands: a link between cutaneous T-cell lymphoma and contact allergy to potassium dichromate, nickel and cobalt?
- Author
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Tilakaratne D and Sidhu S
- Subjects
- Aged, Chronic Disease, Cobalt adverse effects, Dermatitis, Allergic Contact pathology, Gene Rearrangement, Humans, Lymphoma, T-Cell, Cutaneous genetics, Lymphoma, T-Cell, Cutaneous pathology, Male, Middle Aged, Nickel adverse effects, Potassium Dichromate adverse effects, Receptors, Antigen, T-Cell genetics, Cobalt immunology, Dermatitis, Allergic Contact etiology, Lymphoma, T-Cell, Cutaneous immunology, Nickel immunology, Potassium Dichromate immunology
- Abstract
It has been proposed that chronic antigenic stimulation plays a role in the pathogenesis of cutaneous T-cell lymphoma (CTCL). By definition, antigenic stimulation triggers allergic contact dermatitis (ACD). It is therefore plausible that chronic ACD could serve as a precursor to CTCL. We report two cases of contact allergy to potassium dichromate, nickel and cobalt, where CTCL was diagnosed in one patient, and a diagnosis of CTCL is imminent in the other. We also review the literature on the diagnostic criteria for CTCL in the setting of ACD and explore potential mechanisms for the progression from ACD tos CTCL., (© 2014 The Australasian College of Dermatologists.)
- Published
- 2015
- Full Text
- View/download PDF
19. Geo-helminth infections in a rural area of Sri Lanka.
- Author
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Fernando SD, Goonethilleke H, Weerasena KH, Kuruppuarachchi ND, Tilakaratne D, de Silva D, and Wickremasinghe AR
- Subjects
- Adolescent, Anemia, Iron-Deficiency complications, Anthelmintics therapeutic use, Child, Cross-Sectional Studies, Helminthiasis drug therapy, Humans, Intestinal Diseases, Parasitic drug therapy, Mebendazole therapeutic use, Nutritional Status, Prevalence, Socioeconomic Factors, Sri Lanka epidemiology, Helminthiasis epidemiology, Intestinal Diseases, Parasitic epidemiology, Rural Health
- Abstract
School children carry the heaviest burden of morbidity due to intestinal helminth infection. The objective of this investigation was to study geo-helminth infections in 349 school children aged 6 to 13 years living in a rural area of Sri Lanka. Stool samples were examined by direct saline smear in an initial survey to determine the prevalence of intestinal parasitic infections and thereafter the children were followed up over a two year period with cross sectional surveys of stool samples being carried out at yearly intervals. Following collection of a stool sample, all the subjects were treated with mebendazole 500 mg as a single dose. Weights and heights were measured using standardized procedures. 2 ml of venous blood were collected from each subject under aseptic conditions to determine hematological indices. The prevalence of geo-helminth infections was low, and the prevalence declined during the two-year period from 5.4% in 1997 to 2.2% in 1998 and 2.0% in 1999 following yearly mass anti-helminth treatment. The incidence density was 0.021 cases per child year. The reduction in the prevalence from the baseline to the second survey is probably due to the reduction of the reservoir of infection among children as a result of mass treatment at baseline. The prevalence of infection during the second and third surveys were almost the same probably due to infections originating from other segments of the untreated population.
- Published
- 2001
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