200 results on '"Tikkanen, H."'
Search Results
2. Balancing profitability of energy production, societal impacts and biodiversity in offshore wind farm design
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Virtanen, E.A., Lappalainen, J., Nurmi, M., Viitasalo, M., Tikanmäki, M., Heinonen, J., Atlaskin, E., Kallasvuo, M., Tikkanen, H., and Moilanen, A.
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- 2022
- Full Text
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3. Vacuum Rabi splitting and strong coupling dynamics for surface plasmon polaritons and Rhodamine 6G molecules
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Hakala, T. K., Toppari, J. J., Kuzyk, A., Pettersson, M., Tikkanen, H., Kunttu, H., and Törmä, P.
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Physics - Optics - Abstract
We report on strong coupling between surface plasmon polaritons (SPP) and Rhodamine 6G (R6G) molecules, with double vacuum Rabi splitting energies up to 230 and 110 meV. In addition, we demonstrate the emission of all three energy branches of the strongly coupled SPP-exciton hybrid system, revealing features of system dynamics that are not visible in conventional reflectometry. Finally, in analogy to tunable-Q microcavities, we show that the Rabi splitting can be controlled by adjusting the interaction time between waveguided SPPs and R6G deposited on top of the waveguide. The interaction time can be controlled with sub-fs precision by adjusting the length of the R6G area with standard lithography methods., Comment: 4 pages, 4 figures
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- 2009
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4. Insulin resistance without coexisting hyperglycaemia is not independently associated with cardiorespiratory fitness or its components in women
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Rissanen, A, primary, Rissanen, J, additional, Poyhonen-Alho, M, additional, Tiitinen, A, additional, Tikkanen, H O, additional, Shoemaker, J K, additional, Petrella, R, additional, and Peltonen, J E, additional
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- 2023
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5. Cardiorespiratory fitness and health‐related quality of life in women at risk for gestational diabetes
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Engberg, E., Tikkanen, H. O., Koponen, A., Hägglund, H., Kukkonen‐Harjula, K., Tiitinen, A., Peltonen, J. E., and Pöyhönen‐Alho, M.
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- 2018
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6. Balancing profitability of energy production, societal impacts and biodiversity in offshore wind farm design
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Virtanen, E. (E.A.), Lappalainen, J. (J.), Nurmi, M. (M.), Viitasalo, M. (M.), Tikanmäki, M. (M.), Heinonen, J. (J.), Atlaskin, E. (E.), Kallasvuo, M. (M.), Tikkanen, H. (H.), Moilanen, A. (A.), Virtanen, E. (E.A.), Lappalainen, J. (J.), Nurmi, M. (M.), Viitasalo, M. (M.), Tikanmäki, M. (M.), Heinonen, J. (J.), Atlaskin, E. (E.), Kallasvuo, M. (M.), Tikkanen, H. (H.), and Moilanen, A. (A.)
- Abstract
The global demand for renewable energy is on the rise. Expansion of onshore wind energy is in many parts of the world limited by societal acceptance, and also ecological impacts are a concern. Here, pragmatic methods are developed for the integration of high-dimensional spatial data in offshore wind energy planning. Over 150 spatial data layers are created, which either oppose or support offshore wind energy development, and represent ecological, societal, and economic factors. The method is tested in Finland, where interest in developing offshore wind energy is growing. Analyses were done using a spatial prioritization approach, originally developed for the prioritization of high-dimensional ecological data, and rarely used in planning offshore wind energy. When all criteria are integrated, it is possible to find a balanced solution where offshore wind farms cause little disturbance to biodiversity and society, while at the same time yielding high profitability for wind energy production. Earlier proposed areas for offshore wind farms were also evaluated. They were generally well suited for wind power, with the exception of a couple of areas with comparatively high environmental impacts. As an outcome, new areas well suited for large scale wind power deployment were recognized, where construction costs would be moderate and disturbance to biodiversity, marine industries and people limited. A novel tradeoff visualization method was also developed for the conflicts and synergies of offshore energy deployment, which could ease the dialogue between different stakeholders in a spatial planning context. Overall, this study provides a generic and transparent approach for well-informed analysis of offshore wind energy development potential when conflict resolution between biodiversity, societal factors and economic profits is needed. The proposed approach is replicable elsewhere in the world. It is also structurally suitable for the planning of impact avoidance an
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- 2022
7. Physical inactivity in COPD and increased patient perception of dyspnea
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Katajisto M, Kupiainen H, Rantanen P, Lindqvist A, Kilpeläinen M, Tikkanen H, and Laitinen T
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Diseases of the respiratory system ,RC705-779 - Abstract
Milla Katajisto,1 Henna Kupiainen,1 Piritta Rantanen,1 Ari Lindqvist,1 Maritta Kilpeläinen,2 Heikki Tikkanen,3 Tarja Laitinen21Clinical Research Unit for Pulmonary Diseases and Division of Pulmonology, Helsinki University Central Hospital, Helsinki, Finland; 2Department of Pulmonary Diseases and Clinical Allergology, Turku University Hospital and University of Turku, Turku, Finland; 3Department of Sports and Exercise Medicine, Institute of Clinical Medicine, Helsinki University and Foundation of Sports and Exercise Medicine, Helsinki, FinlandObjective: To study patients’ levels of exercise activity and the clinical characteristics that relate to physical activity and inactivity among patients with chronic obstructive pulmonary disease (COPD).Methods: A postal questionnaire was administered to 719 patients with COPD in 2010; patients were recruited from the Helsinki and Turku University Central Hospitals in Finland and have been followed since 2005. The questionnaire asked participants about their exercise routines and other daily activities, potential restrictions to exercise, health-related quality of life, and subjective sensations of dyspnea upon exertion.Results: A total of 50% of the participants reported exercising > 2 times a week throughout the year. The proportion of the exercise inactive patients increased in parallel with disease progression, but the participants exhibited great variation in the degree of activity as well as in sport choices. Year-round activity was better maintained among patients who exercised both indoors and outdoors. Training activity was significantly correlated with patients’ reported subjective dyspnea (r = 0.32, P < 0.001), health-related quality of life (r = 0.25, P < 0.001), mobility score (r = 0.37, P < 0.001), and bronchial obstruction (r = 0.18, P < 0.001). Active patients did not differ from inactive patients in terms of sex, age, smoking status, somatic comorbidities, or body mass index. Irrespective of the level of severity of patients’ COPD, the most significant barrier to exercising was the subjective sensation of dyspnea.Conclusion: When a patient with COPD suffers from dyspnea and does not have regular exercise routines, the patient will most likely benefit from an exercise program tailored to his or her physical capabilities.Keywords: COPD, physical fitness, exercise training, physical activity, pulmonary rehabilitation
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- 2012
8. Habitat use by post-fledging white-tailed eagles shows avoidance of human infrastructure and agricultural areas
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Balotari-Chiebao, F. (Fabio), Brommer, J. E. (Jon E.), Tikkanen, H. (Hannu), Laaksonen, T. (Toni), Balotari-Chiebao, F. (Fabio), Brommer, J. E. (Jon E.), Tikkanen, H. (Hannu), and Laaksonen, T. (Toni)
- Abstract
Habitat use studies provide invaluable information for the conservation of species that suffer from habitat loss or degradation. We used satellite telemetry to study the habitat use of white-tailed eagles (Haliaeetus albicilla) in relation to six habitat classes (artificial surfaces, agricultural areas, forests, semi-natural areas, wetlands and waterbodies) and five forest age classes (0–9, 10–19, 20–59, 60–99 and ≥ 100 years old) during the post-fledging period in Finland. The post-fledging period, defined here as the period between fledging and dispersal from the natal area, is a critical life-history stage. Our primary objective was to provide information that could be integrated into landscape planning, including wind-energy development (which poses a threat to white-tailed eagles). We found that the habitat classes that were selected by the young white-tailed eagles were forests, semi-natural areas (i.e., transitional woodland and bare rock) and wetlands. When using forests, the eagles selected stands of 0–9 years old, presumably due to the use of retention trees surrounded by a clear-cut as perching sites. Conversely, the habitat classes that were avoided were artificial surfaces, agricultural areas and (the immediate vicinity of) waterbodies. We conclude that the conversion of natural habitats into built and agricultural areas is detrimental to young white-tailed eagles because it reduces habitat availability. They, however, appear to be capable of using forests recently impacted by forestry if perch trees are present. Careful landscape planning is needed to protect priority habitats and avoid conflicts with an expanding white-tailed eagle population (e.g., by building wind farms in areas already environmentally disturbed).
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- 2021
9. Diet and breeding habitat preferences of White-tailed Eagles in a northern inland environment
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Ekblad, C. (Camilla), Tikkanen, H. (Hannu), Sulkava, S. (Seppo), Laaksonen, T. (Toni), Ekblad, C. (Camilla), Tikkanen, H. (Hannu), Sulkava, S. (Seppo), and Laaksonen, T. (Toni)
- Abstract
Many apex predator populations are recolonizing old areas and dispersing to new ones, with potential consequences for their prey species and for livestock. An increasing population of the White-tailed Eagle (Haliaeetus albicilla) has settled north of the Arctic Circle in northern Finland, mainly at two big water reservoirs but also in areas with mainly terrestrial habitat. We examined nesting habitat preferences and prey use of White-tailed Eagles in this environment, where reindeer husbandry is a traditional livelihood and concerns are rising that the growing White-tailed Eagle population poses a threat to reindeer calves. Lakes, peat bogs, and marshlands were preferred habitats in the nesting territories. Fish constituted 64.3% of the identified prey items, with birds accounting for 28.5% and mammals 7.2%. The nesting territory habitat within a 10 km radius and the latitude influenced the prey composition at both the group and species level. The occurrence of reindeer calves as prey increased with latitude but was not associated with any habitat. Knowledge of the diet and territory preferences can be used to predict future dispersal and local prey use of this species. Nesting White-tailed Eagles do not seem to pose a threat to traditional reindeer herding, but further research is needed regarding non-breeding sub-adults and whether the White-tailed Eagles actually kill reindeer calves or simply exploit their carcasses.
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- 2020
10. Effect of physical activity and muscle morphology on endothelial function and arterial stiffness
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Rönnback, M., Hernelahti, M., Hämäläinen, E., Groop, P. H., and Tikkanen, H.
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- 2007
11. Alteration of regulatory enzyme activities in fast-twitch and slow-twitch muscles and muscle fibres in low-intensity endurance-trained rats
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Tikkanen, H. O., Näveri, H. K., and Härkönen, M. H.
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- 1995
- Full Text
- View/download PDF
12. Respiratory symptoms, bronchial responsiveness, and cellular characteristics of induced sputum in elite swimmers
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Helenius, I. J., Rytilä, P., Metso, T., Haahtela, T., Venge, P., and Tikkanen, H. O.
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- 1998
13. New genetic loci link adipose and insulin biology to body fat distribution
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Shungin, D, Winkler, T, Croteau Chonka, D, Ferreira, T, Locke, A, Mägi, R, Strawbridge, R, Pers, T, Fischer, K, Justice, A, Workalemahu, T, Wu, J, Buchkovich, M, Heard Costa, N, Roman, T, Drong, A, Song, C, Gustafsson, S, Day, F, Esko, T, Fall, T, Kutalik, Z, Luan, J, Randall, J, Scherag, A, Vedantam, S, Wood, A, Chen, J, Fehrmann, R, Karjalainen, J, Kahali, B, Liu, C, Schmidt, E, Absher, D, Amin, N, Anderson, D, Beekman, M, Bragg Gresham, J, Buyske, S, Demirkan, A, Ehret, G, Feitosa, M, Goel, A, Jackson, A, Johnson, T, Kleber, M, Kristiansson, K, Mangino, M, Leach, I, Medina Gomez, C, Palmer, C, Pasko, D, Pechlivanis, S, Peters, M, Prokopenko, I, Stanca'Kova', A, Sung, Y, Tanaka, T, Teumer, A, Van Vliet Ostaptchouk, J, Yengo, L, Zhang, W, Albrecht, E, Ärnlöv, J, Arscott, G, Bandinelli, S, Barrett, A, Bellis, C, Bennett, A, Berne, C, Blüher, M, Böhringer, S, Bonnet, F, Böttcher, Y, Bruinenberg, M, Carba, D, Caspersen, I, Clarke, R, Daw, E, Deelen, J, Deelman, E, Delgado, G, Doney, A, Eklund, N, Erdos, M, Estrada, K, Eury, E, Friedrich, N, Garcia, M, Giedraitis, V, Gigante, B, Go, A, Golay, A, Grallert, H, Grammer, T, Gräsler, J, Grewal, J, Groves, C, Haller, T, Hallmans, G, Hartman, C, Hassinen, M, Hayward, C, Heikkilä, K, Herzig, K, Helmer, Q, Hillege, H, Holmen, O, Hunt, S, Isaacs, A, Ittermann, T, James, A, Johansson, I, Juliusdottir, T, Kalafati, I, Kinnunen, L, Koenig, W, Kooner, I, Kratzer, W, Lamina, C, Leander, K, Lee, N, Lichtner, P, Lind, L, Lindström, J, Lobbens, S, Lorentzon, M, Mach, F, Magnusson, P, Mahajan, A, Mcardle, W, Menni, C, Merger, S, Mihailov, E, Milani, L, Mills, R, Moayyeri, A, Monda, K, Mooijaart, S, Mühleisen, T, Mulas, A, Müller, G, Müller Nurasyid, M, Nagaraja, R, Nalls, M, Narisu, N, Glorioso, N, Nolte, I, Olden, M, Rayner, N, Renstrom, F, Ried, J, Robertson, N, Rose, L, Sanna, S, Scharnagl, H, Scholtens, S, Sennblad, B, Seufferlein, T, Sitlani, C, Smith, A, Stirrups, K, Stringham, H, Sundström, J, Swertz, M, Swift, A, Syvänen, A, Tayo, B, Thorand, B, Thorleifsson, G, Tomaschitz, A, Troffa, C, Van Oort, F, Verweij, N, Vonk, J, Waite, L, Wennauer, R, Wilsgaard, T, Wojczynski, M, Wong, A, Zhang, Q, Zhao, J, Brennan, E, Choi, M, Eriksson, P, Folkersen, L, Franco Cereceda, A, Gharavi, A, Hedman, A, Hivert, M, Huang, J, Kanoni, S, Karpe, F, Keildson, S, Kiryluk, K, Liang, L, Lifton, R, Ma, B, Mcknight, A, Mcpherson, R, Metspalu, A, Min, J, Moffatt, M, Montgomery, G, Murabito, J, Nicholson, G, Nyholt, D, Olsson, C, Perry, J, Reinmaa, E, Salem, R, Sandholm, N, Schadt, E, Scott, R, Stolk, L, Vallejo, E, Westra, H, Zondervan, K, Amouyel, P, Arveiler, D, Bakker, S, Beilby, J, Bergman, R, Blangero, J, Brown, M, Burnier, M, Campbell, H, Chakravarti, A, Chines, P, Claudi Boehm, S, Collins, F, Crawford, D, Danesh, J, De Faire, U, De Geus, E, Dörr, M, Erbel, R, Eriksson, J, Farrall, M, Ferrannini, E, Ferrières, J, Forouhi, N, Forrester, T, Franco, O, Gansevoort, R, Gieger, C, Gudnason, V, Haiman, C, Harris, T, Hattersley, A, Heliövaara, M, Hicks, A, Hingorani, A, Hoffmann, W, Hofman, A, Homuth, G, Humphries, S, Hyppönen, E, Illig, T, Jarvelin, M, Johansen, B, Jousilahti, P, Jula, A, Kaprio, J, Kee, F, Keinanen Kiukaanniemi, S, Kooner, J, Kooperberg, C, Kovacs, P, Kraja, A, Kumari, M, Kuulasmaa, K, Kuusisto, J, Lakka, T, Langenberg, C, Le Marchand, L, Lehtimäki, T, Lyssenko, V, Männistö, S, Marette, A, Matise, T, Mckenzie, C, Mcknight, B, Musk, A, Möhlenkamp, S, Morris, A, Nelis, M, Ohlsson, C, Oldehinkel, A, Ong, K, Palmer, L, Penninx, B, Peters, A, Pramstaller, P, Raitakari, O, Rankinen, T, Rao, D, Rice, T, Ridker, P, Ritchie, M, Rudan, I, Salomaa, V, Samani, N, Saramies, J, Sarzynski, M, Schwarz, P, Shuldiner, A, Staessen, J, Steinthorsdottir, V, Stolk, R, Strauch, K, Tönjes, A, Tremblay, A, Tremoli, E, Vohl, M, Völker, U, Vollenweider, P, Wilson, J, Witteman, J, Adair, L, Bochud, M, Boehm, B, Bornstein, S, Bouchard, C, Cauchi, S, Caulfield, M, Chambers, J, Chasman, D, Cooper, R, Dedoussis, G, Ferrucci, L, Froguel, P, Grabe, H, Hamsten, A, Hui, J, Hveem, K, Jöckel, K, Kivimaki, M, Kuh, D, Laakso, M, Liu, Y, März, W, Munroe, P, Njolstad, I, Oostra, B, Pedersen, N, Perola, M, Pe'Russe, L, Peters, U, Power, C, Quertermous, T, Rauramaa, R, Rivadeneira, F, Saaristo, T, Saleheen, D, Sinisalo, J, Slagboom, P, Snieder, H, Spector, T, Thorsteinsdottir, U, Stumvoll, M, Tuomilehto, J, Uitterlinden, A, Uusitupa, M, Van Der Harst, P, Veronesi, G, Walker, M, Wareham, N, Watkins, H, Wichmann, H, Abecasis, G, Assimes, T, Berndt, S, Boehnke, M, Borecki, I, Deloukas, P, Franke, L, Frayling, T, Groop, L, Hunter, D, Kaplan, R, O'Connell, J, Qi, L, Schlessinger, D, Strachan, D, Stefansson, K, Van Duijn, C, Willer, C, Visscher, P, Yang, J, Hirschhorn, J, Zillikens, M, Mccarthy, M, Speliotes, E, North, K, Fox, C, Barroso, I, Franks, P, Ingelsson, E, Heid, I, Loos, R, Cupples, L, Lindgren, C, Mohlke, K, Dastani, Z, Timpson, N, Yuan, X, Henneman, P, Kizer, J, Lyytikainen, L, Fuchsberger, C, Small, K, Coassin, S, Lohman, K, Pankow, J, Uh, H, Wu, Y, Bidulescu, A, Rasmussen Torvik, L, Greenwood, C, Ladouceur, M, Grimsby, J, Manning, A, Mooser, V, Kapur, K, Frants, R, Willemsvan vanDijk, K, Willems, S, Psaty, B, Tracy, R, Brody, J, Chen, I, Viikari, J, Kähönen, M, Evans, D, St Pourcain, B, Sattar, N, Carlson, O, Egan, J, van Heemst, D, Kedenko, L, Nuotio, M, Loo, B, Kanaya, A, Haun, M, Klopp, N, Katsareli, E, Couper, D, Duncan, B, Kloppenburg, M, Borja, J, Musani, S, Guo, X, Semple, R, Teslovich, T, Allison, M, Redline, S, Buxbaum, S, Meulenbelt, I, Ballantyne, C, Hu, F, Paulweber, B, Florez, J, Smith, G, Siscovick, D, Kronenberg, F, van Duijn, C, Waterworth, D, Meigs, J, Dupuis, J, Richards, J, Willenborg, C, Thompson, J, Erdmann, J, Goldstein, B, König, I, Cazier, J, Johansson, Å, Hall, A, Lee, J, Grundberg, E, Havulinna, A, Ho, W, Hopewell, J, Eriksson, N, Lundmark, P, Lyytikäinen, L, Rafelt, S, Tikkanen, E, Van Zuydam, N, Voight, B, Ziegler, A, Altshuler, D, Balmforth, A, Braund, P, Burgdorf, C, Cox, D, Dimitriou, M, Do, R, El Mokhtari, N, Fontanillas, P, Hager, J, Han, B, Kang, H, Kessler, T, Knowles, J, Kolovou, G, Langford, C, Lokki, M, Lundmark, A, Meisinger, C, Melander, O, Maouche, S, Nikus, K, Peden, J, Rasheed, A, Rosinger, S, Rubin, D, Rumpf, M, Schäfer, A, Sivananthan, M, Stewart, A, Tan, S, Thorgeirsson, G, van der Schoot, C, Wagner, P, Wells, G, Wild, P, Yang, T, Basart, H, Boerwinkle, E, Brambilla, P, Cambien, F, Cupples, A, de Faire, U, Dehghan, A, Diemert, P, Epstein, S, Evans, A, Ferrario, M, Gauguier, D, Goodall, A, Hazen, S, Holm, H, Iribarren, C, Jang, Y, Kim, H, Laaksonen, R, Ouwehand, W, Parish, S, Park, J, Rader, D, Shah, S, Stark, K, Trégouët, D, Virtamo, J, Wallentin, L, Zimmermann, M, Nieminen, M, Hengstenberg, C, Sandhu, M, Pastinen, T, Hovingh, G, Zalloua, P, Siegbahn, A, Schreiber, S, Ripatti, S, Blankenberg, S, O'Donnell, C, Reilly, M, Collins, R, Kathiresan, S, Roberts, R, Schunkert, H, Pattaro, C, Köttgen, A, Garnaas, M, Böger, C, Chen, M, Tin, A, Taliun, D, Li, M, Gao, X, Gorski, M, Yang, Q, Hundertmark, C, Foster, M, O'Seaghdha, C, Glazer, N, Struchalin, M, Li, G, Johnson, A, Gierman, H, Hwang, S, Atkinson, E, Cornelis, M, Chouraki, V, Holliday, E, Sorice, R, Deshmukh, H, Ulivi, S, Chu, A, Murgia, F, Trompet, S, Imboden, M, Kollerits, B, Pistis, G, Launer, L, Aspelund, T, Eiriksdottir, G, Mitchell, B, Schmidt, H, Cavalieri, M, Rao, M, de Andrade, M, Turner, S, Ding, J, Andrews, J, Freedman, B, Döring, A, Kolcic, I, Zemunik, T, Boban, M, Minelli, C, Wheeler, H, Igl, W, Zaboli, G, Wild, S, Wright, A, Ellinghaus, D, Nöthlings, U, Jacobs, G, Biffar, R, Endlich, K, Ernst, F, Kroemer, H, Nauck, M, Stracke, S, Völzke, H, Aulchenko, Y, Polasek, O, Hastie, N, Vitart, V, Helmer, C, Wang, J, Ruggiero, D, Bergmann, S, Nikopensius, T, Province, M, Ketkar, S, Colhoun, H, Robino, A, Giulianini, F, Krämer, B, Portas, L, Ford, I, Buckley, B, Adam, M, Thun, G, Sala, C, Metzger, M, Mitchell, P, Ciullo, M, Kim, S, Gasparini, P, Pirastu, M, Jukema, J, Probst Hensch, N, Toniolo, D, Coresh, J, Schmidt, R, Kardia, S, Curhan, G, Gyllensten, U, Franke, A, Rettig, R, Parsa, A, Goessling, W, Kao, W, de Boer, I, Peralta, C, Akylbekova, E, Kramer, H, van der Harst, P, Arking, D, Franceschini, N, Hernandez, D, Townsend, R, Lumley, T, Kestenbaum, B, Haritunians, T, Waeber, G, Lu, X, Leak, T, Aasarød, K, Skorpen, F, Baumert, J, Devuyst, O, Mychaleckyj, J, Hallan, S, Navis, G, Shlipak, M, Bull, S, Paterson, A, Rotter, J, Beckmann, J, Dreisbach, A, Styrkarsdottir, U, Evangelou, E, Hsu, Y, Duncan, E, Ntzani, E, Oei, L, Albagha, O, Kemp, J, Koller, D, Minster, R, Vandenput, L, Willner, D, Xiao, S, Yerges Armstrong, L, Zheng, H, Alonso, N, Kammerer, C, Kaptoge, S, Leo, P, Wilson, S, Aalto, V, Alen, M, Aragaki, A, Center, J, Dailiana, Z, Duggan, D, Garcia Giralt, N, Giroux, S, Hocking, L, Husted, L, Jameson, K, Khusainova, R, Kim, G, Koromila, T, Kruk, M, Laaksonen, M, Lacroix, A, Lee, S, Leung, P, Lewis, J, Masi, L, Mencej Bedrac, S, Nguyen, T, Nogues, X, Patel, M, Prezelj, J, Scollen, S, Siggeirsdottir, K, Svensson, O, Trummer, O, van Schoor, N, Woo, J, Zhu, K, Balcells, S, Brandi, M, Cheng, S, Christiansen, C, Cooper, C, Frost, M, Goltzman, D, González Macías, J, Karlsson, M, Khusnutdinova, E, Koh, J, Kollia, P, Langdahl, B, Leslie, W, Lips, P, Ljunggren, Ö, Lorenc, R, Marc, J, Mellström, D, Obermayer Pietsch, B, Olmos, J, Pettersson Kymmer, U, Reid, D, Riancho, J, Rousseau, F, Tang, N, Urreizti, R, Van Hul, W, Zarrabeitia, M, Castano Betancourt, M, Herrera, L, Ingvarsson, T, Johannsdottir, H, Kwan, T, Li, R, Luben, R, Medina Gómez, C, Palsson, S, Reppe, S, Sigurdsson, G, van Meurs, J, Verlaan, D, Williams, F, Zhou, Y, Gautvik, K, Raychaudhuri, S, Cauley, J, Clark, G, Cummings, S, Danoy, P, Dennison, E, Eastell, R, Eisman, J, Jackson, R, Jones, G, Khaw, K, Mccloskey, E, Nandakumar, K, Peacock, M, Pols, H, Prince, R, Reid, I, Robbins, J, Sambrook, P, Sham, P, Tylavsky, F, Econs, M, Kung, A, Reeve, J, Streeten, E, Karasik, D, Ralston, S, Ioannidis, J, Kiel, D, Forsblom, C, Isakova, T, Mckay, G, Williams, W, Sadlier, D, Mäkinen, V, Swan, E, Boright, A, Ahlqvist, E, Keller, B, Huang, H, Ahola, A, Fagerholm, E, Gordin, D, Harjutsalo, V, He, B, Heikkilä, O, Hietala, K, Kytö, J, Lahermo, P, Lehto, M, Österholm, A, Parkkonen, M, Pitkäniemi, J, Rosengård Bärlund, M, Saraheimo, M, Sarti, C, Söderlund, J, Soro Paavonen, A, Syreeni, A, Thorn, L, Tikkanen, H, Tolonen, N, Tryggvason, K, Wadén, J, Gill, G, Prior, S, Guiducci, C, Mirel, D, Taylor, A, Hosseini, M, Parving, H, Rossing, P, Tarnow, L, Ladenvall, C, Alhenc Gelas, F, Lefebvre, P, Rigalleau, V, Roussel, R, Tregouet, D, Maestroni, A, Maestroni, S, Falhammar, H, Gu, T, Möllsten, A, Cimponeriu, D, Mihai, I, Mota, M, Mota, E, Serafinceanu, C, Stavarachi, M, Hanson, R, Nelson, R, Kretzler, M, Panduru, N, Gu, H, Brismar, K, Zerbini, G, Hadjadj, S, Marre, M, Lajer, M, Waggott, D, Savage, D, Bain, S, Martin, F, Godson, C, Groop, P, Maxwell, A, 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- Abstract
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, we conducted genome-wide association meta-analyses of waist and hip circumference-related traits in up to 224,459 individuals. We identified 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (WHRadjBMI) and an additional 19 loci newly associated with related waist and hip circumference measures (P<5×10-8). Twenty of the 49 WHRadjBMI loci showed significant sexual dimorphism, 19 of which displayed a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation, and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.
- Published
- 2015
14. Genetic studies of body mass index yield new insights for obesity biology
- Author
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- Abstract
Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10-8), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20 % of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.
- Published
- 2015
15. Cardiorespiratory fitness and health‐related quality of life in women at risk for gestational diabetes
- Author
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Engberg, E., primary, Tikkanen, H. O., additional, Koponen, A., additional, Hägglund, H., additional, Kukkonen‐Harjula, K., additional, Tiitinen, A., additional, Peltonen, J. E., additional, and Pöyhönen‐Alho, M., additional
- Published
- 2017
- Full Text
- View/download PDF
16. New genetic loci link adipose and insulin biology to body fat distribution.
- Author
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ADIPOGen Consortium, CARDIOGRAMplusC4D Consortium, CKDGen Consortium, GEFOS Consortium, GENIE Consortium, International Endogene Consortium, LifeLines Cohort Study, MAGIC Investigators, MuTHER Consortium, PAGE Consortium, ReproGen Consortium, GLGC, ICBP, Dastani, Z., Hivert, MF., Timpson, N., Perry, JR., Yuan, X., Scott, RA., Henneman, P., Heid, IM., Kizer, JR., Lyytikainen, LP., Fuchsberger, C., Tanaka, T., Morris, AP., Small, K., Isaacs, A., Beekman, M., Coassin, S., Lohman, K., Qi, L., Kanoni, S., Pankow, JS., Uh, HW., Wu, Y., Bidulescu, A., Rasmussen-Torvik, LJ., Greenwood, CM., Ladouceur, M., Grimsby, J., Manning, AK., Liu, CT., Kooner, J., Mooser, VE., Vollenweider, P., Kapur, KA., Chambers, J., Wareham, NJ., Langenberg, C., Frants, R., Willemsvan-vanDijk, K., Oostra, BA., Willems, SM., Lamina, C., Winkler, T., Psaty, BM., Tracy, RP., Brody, J., Chen, I., Viikari, J., Kähönen, M., Pramstaller, PP., Evans, DM., St Pourcain, B., Sattar, N., Wood, A., Bandinelli, S., Carlson, OD., 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LM., Louwers, YV., Marongiu, M., Klaric, IM., Masciullo, C., McKnight, B., Medland, SE., Melzer, D., Newman, AB., Paré, G., Peeters, PH., Plump, AS., Pop, VJ., Räikkönen, K., Salumets, A., Smith, JA., Stacey, SN., Starr, JM., Stathopoulou, MG., Tenesa, A., Thorand, B., Tryggvadottir, L., Tsui, K., van Dam RM., van Gils CH., van Nierop, P., Vink, JM., Voorhuis, M., Wallaschofski, H., Widen, E., Wijnands-van Gent CJ., Zgaga, L., Zygmunt, M., Arnold, AM., Buring, JE., Crisponi, L., Demerath, EW., Hunter, DJ., Schlessinger, D., Murray, A., Murabito, JM., Visser, JA., Lunetta, KL., Elks, CE., Cousminer, DL., Feenstra, B., Lin, P., van Wingerden SW., Smith, EN., Warrington, NM., Alavere, H., Barroso, I., Berenson, GS., Blackburn, H., Busonero, F., Chen, W., Couper, D., Easton, DF., Foroud, T., Geller, F., Hernandez, DG., Kilpeläinen, TO., Li, S., Melbye, M., Murray, JC., Murray, SS., Nelis, M., Ness, AR., Northstone, K., Pennell, CE., Pharoah, P., Rafnar, T., Rice, JP., Ring, SM., Schork, NJ., Segrè, AV., Sovio, U., Srinivasan, SR., Tammesoo, ML., Tyrer, J., Weedon, MN., Wichmann, H., Young, L., Zhuang, WV., Bierut, LJ., Boyd, HA., Winkler, T.W., Croteau-Chonka, D.C., Locke, A.E., Strawbridge, R.J., Pers, T.H., Justice, A.E., Workalemahu, T., Wu, J.M., Buchkovich, M.L., Heard-Costa, N.L., Roman, T.S., Drong, A.W., Day, F.R., Luan, J., Randall, J.C., Scherag, A., Wood, A.R., Fehrmann, R., Karjalainen, J., Kahali, B., Liu, C.T., Schmidt, E.M., Anderson, D., Bragg-Gresham, J.L., Ehret, G.B., Feitosa, M.F., Jackson, A.U., Kleber, M.E., Mateo Leach, I., Medina-Gomez, C., Palmer, C.D., Pasko, D., Pechlivanis, S., Peters, M.J., Ju Sung, Y., Van Vliet-Ostaptchouk, J.V., Yengo, L., Arscott, G.M., Bellis, C., Bennett, A.J., Berne, C., Blüher, M., Bonnet, F., Böttcher, Y., Carba, D.B., Caspersen, I.H., Daw, E.W., Deelen, J., Delgado, G., Doney, A.S., Eklund, N., Erdos, M.R., Eury, E., Friedrich, N., Garcia, M.E., Giedraitis, V., Go, A.S., Golay, A., Grammer, T.B., Gräßler, J., Grewal, J., Groves, C.J., Hartman, C.A., Hassinen, M., Herzig, K.H., Helmer, Q., Hillege, H.L., Holmen, O., Hunt, S.C., Ittermann, T., James, A.L., Johansson, I., Juliusdottir, T., Kalafati, I.P., Kinnunen, L., Kooner, I.K., Lee, N.R., Lichtner, P., Lobbens, S., Magnusson, P.K., McArdle, W.L., Menni, C., Merger, S., Milani, L., Mills, R., Monda, K.L., Mooijaart, S.P., Mühleisen, T.W., Mulas, A., Nalls, M.A., Glorioso, N., Nolte, I.M., Rayner, N.W., Renstrom, F., Ried, J.S., Robertson, N.R., Rose, L.M., Scholtens, S., Seufferlein, T., Sitlani, C.M., Vernon Smith, A., Stringham, H.M., Sundström, J., Swertz, M.A., Swift, A.J., Syvänen, A.C., Tayo, B.O., Tomaschitz, A., Troffa, C., van Oort, F.V., Vonk, J.M., Waite, L.L., Wennauer, R., Wojczynski, M.K., Zhang, Q., Hua Zhao, J., Brennan, E.P., Choi, M., Gharavi, A.G., Hedman, Å.K., Hivert, M.F., Huang, J., Karpe, F., Kiryluk, K., Liang, L., Lifton, R.P., Ma, B., McKnight, A.J., McPherson, R., Min, J.L., Moffatt, M.F., Montgomery, G.W., Murabito, J.M., Nicholson, G., Nyholt, D.R., Olsson, C., Perry, J.R., Reinmaa, E., Salem, R.M., Schadt, E.E., Scott, R.A., Vallejo, E.E., Westra, H.J., Zondervan, K.T., Bakker, S.J., Beilby, J., Bergman, R.N., Blangero, J., Brown, M.J., Chines, P.S., Collins, F.S., Crawford, D.C., de Geus, E.J., Erbel, R., Eriksson, J.G., Ferrannini, E., Forouhi, N.G., Franco, O.H., Gansevoort, R.T., Haiman, C.A., Harris, T.B., Hattersley, A.T., Heliövaara, M., Hicks, A.A., Hingorani, A.D., Hoffmann, W., Humphries, S.E., Jarvelin, M.R., Johansen, B., Jousilahti, P., Jula, A.M., Keinanen-Kiukaanniemi, S.M., Kooner, J.S., Kraja, A.T., Lakka, T.A., Le Marchand, L., Lyssenko, V., Männistö, S., Marette, A., Matise, T.C., McKenzie, C.A., Musk, A.W., Möhlenkamp, S., Morris, A.D., Oldehinkel, A.J., Ong, K.K., Palmer, L.J., Penninx, B.W., Pramstaller, P.P., Raitakari, O.T., Rankinen, T., Rao, D.C., Rice, T.K., Ridker, P.M., Ritchie, M.D., Samani, N.J., Sarzynski, M.A., Schwarz, P.E., Shuldiner, A.R., Staessen, J.A., Steinthorsdottir, V., Stolk, R.P., Strauch, K., Tremblay, A., Vohl, M.C., Wilson, J.F., Witteman, J.C., Adair, L.S., Boehm, B.O., Bornstein, S.R., Bouchard, C., Cauchi, S., Caulfield, M.J., Chambers, J.C., Chasman, D.I., Cooper, R.S., Grabe, H.J., Jöckel, K.H., Munroe, P.B., Oostra, B.A., Palmer, C.N., Pedersen, N.L., Pérusse, L., Saaristo, T.E., Slagboom, P.E., Spector, T.D., Uitterlinden, A.G., Veronesi, G., Walker, M., Wareham, N.J., Wichmann, H.E., Abecasis, G.R., Assimes, T.L., Berndt, S.I., Borecki, I.B., Frayling, T.M., Groop, L.C., Hunter, D.J., Kaplan, R.C., O'Connell, J.R., Strachan, D.P., van Duijn, C.M., Willer, C.J., Visscher, P.M., Yang, J., Hirschhorn, J.N., Zillikens, M.C., McCarthy, M.I., Speliotes, E.K., North, K.E., Fox, C.S., Franks, P.W., Heid, I.M., Loos, R.J., Cupples, L.A., Morris, A.P., Lindgren, C.M., and Mohlke, K.L.
- Abstract
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms.
- Published
- 2015
17. Pääjohtaja Eino S. Repo Yleisradion ohjelmapolitiikan uudistajana 1965–1969
- Author
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Tikkanen, H. (Henry)
- Subjects
History of Science and Ideas - Abstract
Kirjallisuuden maisteri Eino S. Repo (1919–2002) nousi Yleisradion pääjohtajaksi presidentti Urho Kekkosen ja hänen lähipiirinsä ehdokkaana, kulttuurihenkilönä ja kekkoslaisen ulkopolitiikan aktiivisena tukijana vuonna 1965. Pääjohtajana Revon tavoitteena oli Yleisradion ohjelmatoiminnan vapauttaminen konservatiivisesta hegemoniasta, johon yhtiö oli jähmettynyt toisen maailmansodan jälkeen. Tässä tutkimuksessa pyrin selvittämään, millä tavoin Repo kehitti Yleisradion ohjelmapolitiikkaa ja mitkä olivat uudistusten vaikutukset niin ohjelmapolitiikassa että julkisessa keskustelussa. Keskeisenä tutkimuskirjallisuutena olen käyttänyt Raimo Salokankaan ansiokasta yleisradiohistoriikkia Aikansa oloinen sekä lähdekirjana aikalaiskirjallisuuteen lukeutuvaa Pertti Hemánuksen teosta Reporadion nousu ja tuho. Lisäksi Eino S. Revon muistelmateos Pihlajanmarjat on tärkeä lähdeteos tutkimukseni kannalta kuten myös Yleisradion suunta -mietintö, jossa määriteltiin informatiivisen ohjelmapolitiikan ihanteet. Kontekstualisoimalla Revon muistelmia ja muita aikalaislähteitä taustoittavaan tutkimuskirjallisuuteen pyrin löytämään punaisen langan Revon ohjelmapolitiikan takana. Lähdekriittinen ongelma on se, että Repo ei ole suppeissa muistelmissaan juurikaan kertonut julki aatteellisia vaikuttimiaan. Etsin niistä johtolankoja tekemällä päätelmiä Revon sosiaalisen suhdeverkoston sekä hänen henkilö-, koulutus- ja ammattihistoriansa perusteella. Informatiivisen ohjelmapolitiikan teoriapohjaa tulkitsen vertaamalla sitä muun muassa pragmatismiin ja valistusajattelun ihanteisiin. Valtateorioiden avulla hahmottelen Revon johtajaprofiilia ja hänen suhteitaan muihin Yleisradion päättäviin elimiin ja johtajiin. Yleisradion valistus- ja sivistystehtävän täyttämiseksi Repo ryhtyi kehittämään niin kutsuttua informatiivista ohjelmapolitiikkaa, joka perustui tieteellisen tutkimuksen tuloksiin. Se leimattiin julkisuudessa marxilaiseksi retoriikaksi ja aivopesuksi, koska informatiivisen ohjelmapolitiikan päätavoitteena oli yksilön oman ajattelun aktivoiminen. Marxilaisen dialektiikan tavoin Revon johtaman Yleisradion ohjelmistossa etsittiin ratkaisuja ristiriitojen kautta ja hylättiin normiajattelun kahleet. Havaintojeni mukaan Revon ohjelmapoliittinen lähestymiskulma mukaili kuitenkin lähemmin liberalismia ja pragmatismia kuin marxismia, joka oli propagandistisena terminä oikeistolaisten kriitikoiden käytössä. Informatiivisessa ohjelmapolitiikassa oli nähtävissä myös valistusihanteita, jotka liittyivät Yleisradion haluttuun osallistuvaan rooliin kasvatuksessa ja opetuksessa. Niin kutsutun Reporadion historia on täynnä toistuvia kiistoja siitä, mikä on sallittua suomalaisessa radio- ja televisiojulkisuudessa. Mitä voi julkaista ja mitä ei ja mitkä ovat oikean ja mitkä väärän todellisuuskokemuksen tulkintoja. Eino S. Repo oli liberaali ja salliva johtaja, joka antoi toimittajille entistä enemmän vapauksia toteuttaa ohjelmia. Reporadion toimittajat ja ohjelmantekijät kyseenalaistivatkin aktiivisesti niitä rajoja, joita poliitikot olivat Yleisradion toimintaan asettaneet. Reporadio mielletään usein radikalismin ja vasemmiston airueksi, mutta näkemykseni mukaan Eino S. Revon johtama Yleisradio oli varsin edistyksellinen. Ohjelmapoliittinen sisältö sai kuitenkin käytännön tasolla yksipuolisesti porvarillisesta ideologiasta poikkeavia muotoja, millainen tilanne on historiallisesti esiintynyt vain kerran aiemmin Hella Wuolijoen johtaman Yleisradion aikana 1940-luvun loppupuolella. Samankaltaisuutta on havaittavissa myös Revon ja Wuolijoen ammatillisissa kohtaloissa — poliittiselle eliitille epämieluisista pääjohtajista hankkiuduttiin eroon. Uskon tutkimukseni havainnollistavan, että Eino S. Revon käynnistämä ohjelmapoliittinen murros oli erittäin merkittävä tapahtuma Suomen aatehistoriassa. Kenties Revon salliva ja kokeileva asenne avasi sellaisia henkisiä patoja, jotka olisivat aiheuttaneet muussa tapauksessa suurempia yhteiskunnallisia ongelmia.
- Published
- 2013
18. Gastric emptying and serum insulin levels after intake of glucose-polymer solutions
- Author
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Näveri, H., Tikkanen, H., Kairento, A. -L., and Härkönen, M.
- Published
- 1989
- Full Text
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19. Respiratory plasticity in response to changes in oxygen supply and demand
- Author
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Bavis, R W, Powell, F L, Bradford, A, Hsia, C C, Peltonen, J E, Soliz, J, Zeis, B, Fergusson, E K, Fu, Z, Gassmann, M, Kim, C B, Maurer, J, McGuire, M, Miller, B M, O'Halloran, K D, Paul, R J, Reid, S G, Rusko, H K, Tikkanen, H O, Wilkinson, K A, University of Zurich, and Bavis, R W
- Subjects
1110 Plant Science ,570 Life sciences ,biology ,590 Animals (Zoology) ,1103 Animal Science and Zoology ,142-005 142-005 - Published
- 2007
20. Explaining corporate short-termism: self-reinforcing processes and biases among investors, the media and corporate managers
- Author
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Aspara, J., primary, Pajunen, K., additional, Tikkanen, H., additional, and Tainio, R., additional
- Published
- 2014
- Full Text
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21. Sponsoring Relationships And Interpersonal Communication. A Theoretical Basis And Implications
- Author
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Olkkonen, R, Tikkanen, H, and Alajoutsijärvi, K
- Abstract
Although there have been significant changes in marketing thinking during the 1990s, in that various relational approaches have attracted enormous interest among academic marketing researchers, current research on sponsorship seems to be "stuck" in the more traditional, marketing-mix management- and mass communicative effects-based discourse. This paper aims at presenting a theoretical overview of how current sponsorship research could be developed further by applying the basic ideas and concepts provided by the interaction/network approach to the study of sponsorshiprelated phenomena. Adopting interaction/network perspective means that, instead of measuring the mass-communicative effects on various audiences, the focus ib on understanding the development of sponsorship relationships and networks, as well as on interpersonal communication processes going on between the sponsorship parties.
- Published
- 1999
22. The Evolution Of The Distribution Channel Structure And Preferred Interaction Strategies In The European Fast Moving Consumer Goods Business
- Author
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Lindblom, A and Tikkanen, H
- Abstract
In this paper, we analyze the major structural changes in the European fast moving consumer goods business during the last two decades. We primarily focus on changes in what we call the 'distribution channel logic'. Our main interest is to understand 1) how the structural changes have influenced the balance of power between retailers and manufacturers acting in the market, and 2) how this balance or imbalance has affected manufacturers' marketing strategies and retailers' purchasing strategies on a general level.
- Published
- 1999
23. Metaphors And The Structuring of the IMP Network Discourse
- Author
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Alajoutsijärvi, K, Eriksson, P, and Tikkanen, H
- Abstract
In this paper, we explore how metaphors organize the IMP network research questions and subsequent research contributions. Our analysis is based on the argument that we cannot escape metaphors in our speech and writings. We may try to avoid the use of lively metaphors or, alternatively, we may use them in a critical or less critical way. However, we need both metaphorical concepts (such as network is a business system) and different types of lively and dormant metaphors (such as 'relationship', 'change', 'third party' and 'black hole') in order to understand what happens around us in this world and in order to be able to communicate with each other. In the IMP discourse, we were able to identify two partly overlapping, partly incommensurable sub-discourses according to their use of metaphors. "The marital relationship discourse" uses a number of lively metaphors, i.e. it explicitly draws on metaphors in sharing understandings. The second discourse, "network is a business system", clearly relies on a more realist or objectivist viewpoint and seems to reject the explicit metaphorical character of the network concept.
- Published
- 1998
24. Balancing Business Cycles Through Customer Relationship Strategies In The Paper Industry. Conceptual Basis And Managerial Implications For International Suppliers
- Author
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Alajoutsijärvi, K, Klint, M B, and Tikkanen, H
- Abstract
The international paper industry is renown for its drastic, seemingly uncontrollable business cycles. Thus, the balancing of business cycles is one of the most crucial challenges faced by managers in the highly capitalintensive paper industry. The purpose of this paper is twofold. Firstly, we attempt to see the "deep structures" of business cycles in the global paper industry through relevant relationship and network concepts, hoping to go beyond the "surface" of traditional economic indicators and the related, more or less mechanistic explanations. Secondly, in accordance with the adopted perspective, we suggest ways out of the problem by highlighting the importance of a balanced account portfolio and customer relationship strategies that are allied to the business cycle.
- Published
- 1998
25. The Social Construction Of Industrial Networks: Berger and Luckmann's Constructionism As An Ideological Basis For Network Studies
- Author
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Tikkanen, H
- Abstract
Post-industrial conditions affecting contemporary interorganizational marketing could be related to such developments as increasing interorganizational resource dependence, fragmentation of larger industrial networks into smaller cooperative nets characterized by efficient interaction and the complexity of interorganizational actor bonds, activity links and resource ties. Thus, new approaches and theories based on different philosophical assumptions and theoretical perspectives are needed in order to gain better understanding on the more or less postmodern environment encountered in contemporary interorganizational business. Recent network research conducted in Sweden and in the Nordic countries has incrementally developed into quite a different direction, apart from the original, systems theory - oriented network thinking and the objectivist/realist philosophical points of departure obvious in most earlier network studies. For example, Nordic network researchers influenced by the Uppsala School emphasize the subjectivity and contextuality of research, and adopt an intentional, voluntaristic view of human behavior. In our opinion, these often implicit postulats refer to a predominantly relativist/constructivist philosophical orientation. The purpose of this paper is to discuss constructionism, especially the classic social constructionist approach by Berger and Luckmann (1966) as an ideological basis for network studies. First, relativism and constructionism are discussed briefly as scientific orientations on a general level. Second, some central features of Berger and Luckmann's (1966) social constructionist approach
- Published
- 1997
26. North-European Network Research: A Relativistic Perspective
- Author
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Tikkanen, H
- Abstract
There is an obvious dichotomy between network research explicitly based on realist philosophical orientation and a most often implicit, more or less relativistic orientation adopted by several, if not most, network researchers. The purpose of this paper is to present some central ideas and conclusions about such metatheoretical issues and problem areas one should be aware of when considering the use of the network approach in contemporary interorganizational exchange and marketing research. Primarily, these metatheoretical considerations are related to the concepts of scientific approach and research approach. It is our opinion that network researchers should primarily adopt a subjectivistic, relativistically oriented scientific approach. Furthermore, they should favor actionoriented, hermeneutic research approaches aiming at a more thorough understanding of the studied business situations and processes. This can be accomplished, for example, through action research with an emphasis on researcher participation in the studied processes. The achieved understanding should also serve practical goals, i.e. the researcher should not limit his/her attention to theoretical and methodological research objectives only. Moreover, one should aim at solving practical problems encountered in the studied organizations. This should also increase the credibility of network research among practitioners and create more concrete links between network theory and context-specific practical implications.
- Published
- 1996
27. Discovering social capital and value delivery in business markets: A multi-country research odyssey
- Author
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Tuominin, M., Tikkanen, H., Kajalo, S., Rajala, A., Moller, K., Matear, S., Hooley, Graham J., Tuominin, M., Tikkanen, H., Kajalo, S., Rajala, A., Moller, K., Matear, S., and Hooley, Graham J.
- Published
- 2005
28. MS23 TARGETING ONLY HIGH LDL-CHOLESTEROL DOES NOT ELIMINATE RESIDUAL CARDIOVASCULAR RISK
- Author
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Granér, M., primary, Rimpiläinen, O., additional, Tikkanen, H., additional, Lokki, M.-L., additional, Nieminen, M.S., additional, Taskinen, M.-R., additional, and Sinisalo, J., additional
- Published
- 2010
- Full Text
- View/download PDF
29. Vacuum Rabi Splitting and Strong-Coupling Dynamics for Surface-Plasmon Polaritons and Rhodamine 6G Molecules
- Author
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Hakala, T. K., primary, Toppari, J. J., additional, Kuzyk, A., additional, Pettersson, M., additional, Tikkanen, H., additional, Kunttu, H., additional, and Törmä, P., additional
- Published
- 2009
- Full Text
- View/download PDF
30. Frequency conversion of propagating surface plasmon polaritons by organic molecules
- Author
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Hakala, T. K., primary, Toppari, J. J., additional, Pettersson, M., additional, Kuzyk, A., additional, Tikkanen, H., additional, Kunttu, H., additional, and Törmä, P., additional
- Published
- 2008
- Full Text
- View/download PDF
31. Respiratory plasticity in response to changes in oxygen supply and demand
- Author
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Bavis, R. W., primary, Powell, F. L., additional, Bradford, A., additional, Hsia, C. C.W., additional, Peltonen, J. E., additional, Soliz, J., additional, Zeis, B., additional, Fergusson, E. K., additional, Fu, Z., additional, Gassmann, M., additional, Kim, C. B., additional, Maurer, J., additional, McGuire, M., additional, Miller, B. M., additional, O'Halloran, K. D., additional, Paul, R. J., additional, Reid, S. G., additional, Rusko, H. K., additional, Tikkanen, H. O., additional, and Wilkinson, K. A., additional
- Published
- 2007
- Full Text
- View/download PDF
32. Effect of physical activity and muscle morphology on endothelial function and arterial stiffness
- Author
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Rönnback, M., primary, Hernelahti, M., additional, Hämäläinen, E., additional, Groop, P. H., additional, and Tikkanen, H., additional
- Published
- 2006
- Full Text
- View/download PDF
33. Collaborative resources in innovation and global competition: Profitability implications.
- Author
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Tuominen, M., Parvinen, P., Hietanen, J., and Tikkanen, H.
- Published
- 2008
- Full Text
- View/download PDF
34. Exercise-Induced Changes in Pulmonary Function of Healthy, Elite Long-Distance Runners in Cold Air and Pollen Season Exercise Challenge Tests
- Author
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Helenius, I., primary, Tikkanen, H. O., additional, Helenius, M., additional, Lumme, A., additional, Remes, V., additional, and Haahtela, T., additional
- Published
- 2002
- Full Text
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35. EFFECT OF LIVING IN HYPOXIA AND TRAINING IN NORMOXIA ON SEA LEVEL VO2max AND RED CELL MASS
- Author
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Rusko, H. K., primary, Tikkanen, H., additional, Paavolainen, L., additional, H??m??l??inen, I., additional, Kalliokoski, K., additional, and Puranen, A., additional
- Published
- 1999
- Full Text
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36. CARDIAC OUTPUT IN HYPEROXIA, NORMOXIA AND HYPOXIA
- Author
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Peltonen, J. E., primary, Tikkanen, H. O., additional, and Rusko, H. K., additional
- Published
- 1999
- Full Text
- View/download PDF
37. ASTHMA - CROSS-COUNTRY SKIING
- Author
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Tikkanen, H. O., primary and Peltonen, J. E., additional
- Published
- 1999
- Full Text
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38. Occurrence of exercise induced bronchospasm in elite runners: dependence on atopy and exposure to cold air and pollen
- Author
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Helenius, I. J., primary, Tikkanen, H. O., additional, and Haahtela, T., additional
- Published
- 1998
- Full Text
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39. EFFECT OF SKI-RACE ON HEMOGLOBIN CONCENTRATION AND HEMATOCRIT IN ELITE CROSS-COUNTRY SKIERS
- Author
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Rusko, H. K., primary, Tikkanen, H., additional, and Videman, T., additional
- Published
- 1998
- Full Text
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40. GAS EXCHANGE KINETICS DURING MAXIMAL CYCLING IN NORMOXIA, HYPEROXIA AND HYPOXIA
- Author
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Peltonen, J. E., primary, Tikkanen, H. O., additional, and Rusko, H. K., additional
- Published
- 1998
- Full Text
- View/download PDF
41. ASTHMA AND INCREASED BRONCHIAL RESPONSIVENESS IN ELITE SWIMMERS1636
- Author
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Tikkanen, H., primary, Helenius, I., additional, and Haahtela, T., additional
- Published
- 1997
- Full Text
- View/download PDF
42. Association between type of training and risk of asthma in elite athletes
- Author
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Helenius, I. J., primary, Tikkanen, H. O., additional, and Haahtela, T., additional
- Published
- 1997
- Full Text
- View/download PDF
43. Exercise-induced bronchospasm at low temperature in elite runners.
- Author
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Helenius, I J, primary, Tikkanen, H O, additional, and Haahtela, T, additional
- Published
- 1996
- Full Text
- View/download PDF
44. ATOPIC ALLERGY IN ELITE RUNNERS ENHANCES EXERCISE INDUCED BRONCHOSPASM399
- Author
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Helenius, I., primary, Tikkanen, H., additional, and Haahtela, T., additional
- Published
- 1996
- Full Text
- View/download PDF
45. ATOPIC ALLERGY IN RUNNERS ENHANCES BRONCHOSPASM DURING OUTDOOR RUNNING IN WINTER
- Author
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Tikkanen, H., primary, Helenius, I., additional, and Haahtela, T., additional
- Published
- 1995
- Full Text
- View/download PDF
46. ACCLIMATIZATION TO LIVING IN NORMOBARIC HYPOXIA AND TRAINING IN NORMOXIA AT SEA LEVEL IN RUNNERS
- Author
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Laitinen, H., primary, Alopaeus, K., additional, Heikkinen, R., additional, Hietanen, H., additional, Mikkelsson, L., additional, Tikkanen, H., additional, and Rusko, H. K., additional
- Published
- 1995
- Full Text
- View/download PDF
47. Asthma in runners
- Author
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Tikkanen, H O, primary and Helenius, I, additional
- Published
- 1994
- Full Text
- View/download PDF
48. Observed lung markings in normal ehest roentgenograms
- Author
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Vehmas, T., primary, Tikkanen, H., additional, Bondestam, S., additional, Holmberg, J., additional, Kivisaari, A., additional, Knuutila, T., additional, Pölönen, P., additional, and Korhola, O., additional
- Published
- 1993
- Full Text
- View/download PDF
49. Fatty acid-induced increase in serum dialyzable free thyroxine after physical exercise: implication for nonthyroidal illness.
- Author
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Liewendahl, K, primary, Helenius, T, additional, Näveri, H, additional, and Tikkanen, H, additional
- Published
- 1992
- Full Text
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50. Lack of efficacy of phenytoin in children presenting with febrile status epilepticus.
- Author
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Ismail S, Lévy A, Tikkanen H, Sévère M, Wolters FJ, and Carmant L
- Abstract
BACKGROUND: Fever is the most common precipitant of status epilepticus in children. Animal models suggest that only [gamma]-aminobutyric acidic drugs are effective in the treatment of febrile seizures, but there is limited clinical evidence to support this. OBJECTIVE: The aim of this study was to determine the efficacy of phenytoin, a sodium channel blocker, in the treatment of febrile status epilepticus in children. METHODS: This study is a retrospective chart review of 56 children (62 episodes) who presented to our emergency department with febrile status epilepticus and received phenytoin. The clinical parameters were evaluated by reviewing the charts. The efficacy of phenytoin was classified into 3 categories: positive, negative, and nonevaluable response. RESULTS: The primary outcome was to evaluate the efficacy rate of phenytoin; there were 9 (14.5%) of 62 episodes with a positive response, 25 (40.3%) with a negative response, and 28 (45.2%) with a nonevaluable response because phenytoin was given simultaneously with a [gamma]-aminobutyric acidic (GABAergic) drug (P < .001). The secondary outcome was to measure the mean seizure duration for each treatment category, which were 52.8, 109.9, and 52.6 minutes, respectively (P < .01). CONCLUSION: Phenytoin is rarely effective in controlling febrile status epilepticus. Children exposed to phenytoin have more prolonged febrile seizures, increasing the risk of brain injury. [ABSTRACT FROM AUTHOR]
- Published
- 2012
- Full Text
- View/download PDF
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