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21 results on '"Tikhonowski, Gleb V."'

1. Bismuth nanoparticles-enhanced proton therapy: Concept and biological assessment

Author

Zavestovskaya, Irina N., Filimonova, Marina V., Popov, Anton L., Zelepukin, Ivan V., Shemyakov, Alexander E., Tikhonowski, Gleb V., Savinov, Maxim, Filimonov, Alexander S., Shitova, Anna A., Soldatova, Olga V., Kolmanovich, Danil D., Shakhov, Pavel V., Kotelnikova, Polina A., Popov, Anton A., Chukavin, Nikita N., Pivovarov, Nikita A., Syuy, Alexander V., Klimentov, Sergey M., Ryabov, Vladimir A., Ivanov, Sergey A., Kaprin, Andrei D., Prasad, Paras N., Deyev, Sergey M., Koryakin, Sergei N., and Kabashin, Andrei V.

Published
2024
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3. Tungsten Diselenide Nanoparticles Produced via Femtosecond Ablation for SERS and Theranostics Applications.

Author

Ushkov, Andrei, Dyubo, Dmitriy, Belozerova, Nadezhda, Kazantsev, Ivan, Yakubovsky, Dmitry, Syuy, Alexander, Tikhonowski, Gleb V., Tselikov, Daniil, Martynov, Ilya, Ermolaev, Georgy, Grudinin, Dmitriy, Melentev, Alexander, Popov, Anton A., Chernov, Alexander, Bolshakov, Alexey D., Vyshnevyy, Andrey A., Arsenin, Aleksey, Kabashin, Andrei V., Tselikov, Gleb I., and Volkov, Valentyn

Subjects
LIGHT scattering, LASER ablation, PHOTOTHERMAL conversion, CRYSTAL structure, FEMTOSECOND lasers
Abstract

Due to their high refractive index, record optical anisotropy and a set of excitonic transitions in visible range at a room temperature, transition metal dichalcogenides have gained much attention. Here, we adapted a femtosecond laser ablation for the synthesis of WSe2 nanoparticles (NPs) with diameters from 5 to 150 nm, which conserve the crystalline structure of the original bulk crystal. This method was chosen due to its inherently substrate-additive-free nature and a high output level. The obtained nanoparticles absorb light stronger than the bulk crystal thanks to the local field enhancement, and they have a much higher photothermal conversion than conventional Si nanospheres. The highly mobile colloidal state of produced NPs makes them flexible for further application-dependent manipulations, which we demonstrated by creating substrates for SERS sensors. [ABSTRACT FROM AUTHOR]

Published
2025
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5. Laser-synthesized TiN-based nanoparticles as novel efficient electrostatic nanosorbent for environmental water cleaning.

Author

Syuy, Alexander V, Martynov, Ilya V, Zavidovskiy, Ilya A, Dyubo, Dmitry V, Sun, Qingjiang, Yang, Xi, Tikhonowski, Gleb V, Tselikov, Daniil I, Savinov, Maxim S, Sozaev, Islam V, Popov, Anton A, Klimentov, Sergey M, Tselikov, Gleb I, Volkov, Valentyn S, Novikov, Sergey M, Arsenin, Aleksey V, Zhao, Xiangwei, and Kabashin, Andrei V

Published
2024
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6. Laser-Synthesized Germanium Nanoparticles as Biodegradable Material for Near-Infrared Photoacoustic Imaging and Cancer Phototherapy

Author

Belyaev, Iaroslav B., Zelepukin, Ivan V., Kotelnikova, Polina A., Tikhonowski, Gleb V., Popov, Anton A., Kapitannikova, Alina Yu., Barman, Jugal, Kopylov, Alexey N., Bratashov, Daniil N., Prikhozhdenko, Ekaterina S., Kabashin, Andrei V., Deyev, Sergey M., Zvyagin, Andrei V., Belyaev, Iaroslav B., Zelepukin, Ivan V., Kotelnikova, Polina A., Tikhonowski, Gleb V., Popov, Anton A., Kapitannikova, Alina Yu., Barman, Jugal, Kopylov, Alexey N., Bratashov, Daniil N., Prikhozhdenko, Ekaterina S., Kabashin, Andrei V., Deyev, Sergey M., and Zvyagin, Andrei V.

Abstract

Biodegradable nanomaterials can significantly improve the safety profile of nanomedicine. Germanium nanoparticles (Ge NPs) with a safe biodegradation pathway are developed as efficient photothermal converters for biomedical applications. Ge NPs synthesized by femtosecond-laser ablation in liquids rapidly dissolve in physiological-like environment through the oxidation mechanism. The biodegradation of Ge nanoparticles is preserved in tumor cells in vitro and in normal tissues in mice with a half-life as short as 3.5 days. Biocompatibility of Ge NPs is confirmed in vivo by hematological, biochemical, and histological analyses. Strong optical absorption of Ge in the near-infrared spectral range enables photothermal treatment of engrafted tumors in vivo, following intravenous injection of Ge NPs. The photothermal therapy results in a 3.9-fold reduction of the EMT6/P adenocarcinoma tumor growth with significant prolongation of the mice survival. Excellent mass-extinction of Ge NPs (7.9 L g−1 cm−1 at 808 nm) enables photoacoustic imaging of bones and tumors, following intravenous and intratumoral administrations of the nanomaterial. As such, strongly absorbing near-infrared-light biodegradable Ge nanomaterial holds promise for advanced theranostics.

Published
2024
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7. Boron Nanoparticle-Enhanced Proton Therapy : Molecular Mechanisms of Tumor Cell Sensitization

Author

Popov, Anton L., Kolmanovich, Danil D., Chukavin, Nikita N., Zelepukin, Ivan V., Tikhonowski, Gleb V., Pastukhov, Andrei I., Popov, Anton A., Shemyakov, Alexander E., Klimentov, Sergey M., Ryabov, Vladimir A., Deyev, Sergey M., Zavestovskaya, Irina N., Kabashin, Andrei V., Popov, Anton L., Kolmanovich, Danil D., Chukavin, Nikita N., Zelepukin, Ivan V., Tikhonowski, Gleb V., Pastukhov, Andrei I., Popov, Anton A., Shemyakov, Alexander E., Klimentov, Sergey M., Ryabov, Vladimir A., Deyev, Sergey M., Zavestovskaya, Irina N., and Kabashin, Andrei V.

Abstract

Boron-enhanced proton therapy has recently appeared as a promising approach to increase the efficiency of proton therapy on tumor cells, and this modality can further be improved by the use of boron nanoparticles (B NPs) as local sensitizers to achieve enhanced and targeted therapeutic outcomes. However, the mechanisms of tumor cell elimination under boron-enhanced proton therapy still require clarification. Here, we explore possible molecular mechanisms responsible for the enhancement of therapeutic outcomes under boron NP-enhanced proton therapy. Spherical B NPs with a mode size of 25 nm were prepared by methods of pulsed laser ablation in water, followed by their coating by polyethylene glycol to improve their colloidal stability in buffers. Then, we assessed the efficiency of B NPs as sensitizers of cancer cell killing under irradiation with a 160.5 MeV proton beam. Our experiments showed that the combined effect of B NPs and proton irradiation induces an increased level of superoxide anion radical generation, which leads to the depolarization of mitochondria, a drop in their membrane mitochondrial potential, and the development of apoptosis. A comprehensive gene expression analysis (via RT-PCR) confirmed increased overexpression of 52 genes (out of 87 studied) involved in the cell redox status and oxidative stress, compared to 12 genes in the cells irradiated without B NPs. Other possible mechanisms responsible for the B NPs-induced radiosensitizing effect, including one related to the generation of alpha particles, are discussed. The obtained results give a better insight into the processes involved in the boron-induced enhancement of proton therapy and enable one to optimize parameters of proton therapy in order to maximize therapeutic outcomes.

Published
2024
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9. Laser-Ablative Synthesis of Silicon–Iron Composite Nanoparticles for Theranostic Applications

Author

Bubnov, Alexander A., primary, Belov, Vladimir S., additional, Kargina, Yulia V., additional, Tikhonowski, Gleb V., additional, Popov, Anton A., additional, Kharin, Alexander Yu., additional, Shestakov, Mikhail V., additional, Perepukhov, Alexander M., additional, Syuy, Alexander V., additional, Volkov, Valentyn S., additional, Khovaylo, Vladimir V., additional, Klimentov, Sergey M., additional, Kabashin, Andrei V., additional, and Timoshenko, Victor Yu., additional

Published
2023
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10. Boron Nanoparticle-Enhanced Proton Therapy for Cancer Treatment

Author

Zavestovskaya, Irina N., primary, Popov, Anton L., additional, Kolmanovich, Danil D., additional, Tikhonowski, Gleb V., additional, Pastukhov, Andrei I., additional, Savinov, Maxim S., additional, Shakhov, Pavel V., additional, Babkova, Julia S., additional, Popov, Anton A., additional, Zelepukin, Ivan V., additional, Grigoryeva, Maria S., additional, Shemyakov, Alexander E., additional, Klimentov, Sergey M., additional, Ryabov, Vladimir A., additional, Prasad, Paras N., additional, Deyev, Sergey M., additional, and Kabashin, Andrei V., additional

Published
2023
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11. Laser-Synthesized Elemental Boron Nanoparticles for Efficient Boron Neutron Capture Therapy.

Author

Zavestovskaya, Irina N., Kasatova, Anna I., Kasatov, Dmitry A., Babkova, Julia S., Zelepukin, Ivan V., Kuzmina, Ksenya S., Tikhonowski, Gleb V., Pastukhov, Andrei I., Aiyyzhy, Kuder O., Barmina, Ekaterina V., Popov, Anton A., Razumov, Ivan A., Zavjalov, Evgenii L., Grigoryeva, Maria S., Klimentov, Sergey M., Ryabov, Vladimir A., Deyev, Sergey M., Taskaev, Sergey Yu., and Kabashin, Andrei V.

Subjects
BORON-neutron capture therapy, BORON, NEUTRON beams, NEUTRON capture, THERMAL neutrons, RECORDS retention, NEUTRON irradiation
Abstract

Boron neutron capture therapy (BNCT) is one of the most appealing radiotherapy modalities, whose localization can be further improved by the employment of boron-containing nanoformulations, but the fabrication of biologically friendly, water-dispersible nanoparticles (NPs) with high boron content and favorable physicochemical characteristics still presents a great challenge. Here, we explore the use of elemental boron (B) NPs (BNPs) fabricated using the methods of pulsed laser ablation in liquids as sensitizers of BNCT. Depending on the conditions of laser-ablative synthesis, the used NPs were amorphous (a-BNPs) or partially crystallized (pc-BNPs) with a mean size of 20 nm or 50 nm, respectively. Both types of BNPs were functionalized with polyethylene glycol polymer to improve colloidal stability and biocompatibility. The NPs did not initiate any toxicity effects up to concentrations of 500 µg/mL, based on the results of MTT and clonogenic assay tests. The cells with BNPs incubated at a 10B concentration of 40 µg/mL were then irradiated with a thermal neutron beam for 30 min. We found that the presence of BNPs led to a radical enhancement in cancer cell death, namely a drop in colony forming capacity of SW-620 cells down to 12.6% and 1.6% for a-BNPs and pc-BNPs, respectively, while the relevant colony-forming capacity for U87 cells dropped down to 17%. The effect of cell irradiation by neutron beam uniquely was negligible under these conditions. Finally, to estimate the dose and regimes of irradiation for future BNCT in vivo tests, we studied the biodistribution of boron under intratumoral administration of BNPs in immunodeficient SCID mice and recorded excellent retention of boron in tumors. The obtained data unambiguously evidenced the effect of a neutron therapy enhancement, which can be attributed to efficient BNP-mediated generation of α-particles. [ABSTRACT FROM AUTHOR]

Published
2023
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13. Tunable optical properties of transition metal dichalcogenide nanoparticles synthesized by femtosecond laser ablation and fragmentation

Author

Chernikov, Anton S., primary, Tselikov, Gleb I., additional, Gubin, Mikhail Yu., additional, Shesterikov, Alexander V., additional, Khorkov, Kirill S., additional, Syuy, Alexander V., additional, Ermolaev, Georgy, additional, Kazantsev, Ivan S., additional, Romanov, Roman I., additional, Markeev, Andrey, additional, Popov, Anton A., additional, Tikhonowski, Gleb V., additional, Kapitanova, Olesya O., additional, Kochuev, Dmitry A., additional, Leksin, Andrey Yu., additional, Tselikov, Daniil I., additional, Arsenin, Aleksey V, additional, Kabashin, Andrei V., additional, Volkov, Valentyn S., additional, and Prokhorov, Alexei V., additional

Published
2023
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14. Correction: Tunable optical properties of transition metal dichalcogenide nanoparticles synthesized by femtosecond laser ablation and fragmentation

Author

Chernikov, Anton S., primary, Tselikov, Gleb I., additional, Gubin, Mikhail Yu., additional, Shesterikov, Alexander V., additional, Khorkov, Kirill S., additional, Syuy, Alexander V., additional, Ermolaev, Georgy A., additional, Kazantsev, Ivan S., additional, Romanov, Roman I., additional, Markeev, Andrey M., additional, Popov, Anton A., additional, Tikhonowski, Gleb V., additional, Kapitanova, Olesya O., additional, Kochuev, Dmitry A., additional, Leksin, Andrey Yu., additional, Tselikov, Daniil I., additional, Arsenin, Aleksey V., additional, Kabashin, Andrei V., additional, Volkov, Valentyn S., additional, and Prokhorov, Alexei V., additional

Published
2023
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15. Photocatalytic Activity of TiNbC-Modified TiO 2 during Hydrogen Evolution and CO 2 Reduction.

Author

Syuy, Alexander V., Shtarev, Dmitry S., Kozlova, Ekaterina A., Kurenkova, Anna Yu., Zhurenok, Angelina V., Shtareva, Anna V., Gurin, Mikhail S., Tselikov, Gleb I., Tikhonowski, Gleb V., Arsenin, Aleksey, and Volkov, Valentyn

Subjects
PHOTOCATALYSTS, CARBON dioxide, TITANIUM dioxide, CARBON dioxide reduction, HYDROGEN production
Abstract

Photocatalytic CO2 reduction and the production of hydrogen are urgent tasks of green energy. One of the most studied semiconductor photocatalysts for this purpose is titanium dioxide. However, it has a number of fundamental limitations that do not allow its application for such tasks on an industrial scale. Another class of promising materials, which is being investigated very actively, are two-dimensional materials based on MXenes. In this work, we present the first results on photocatalytic hydrogen evolution and CO2 reduction using TiNbC/TiO2 heterostructures with TiNbC contents of 1, 5, and 10%. The approach to the creation of heterostructures proposed in this work may become a significant breakthrough in the search for new highly efficient systems for carbon dioxide reduction and hydrogen production. [ABSTRACT FROM AUTHOR]

Published
2023
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17. Laser Synthesized Core-Satellite Fe-Au Nanoparticles for Multimodal In Vivo Imaging and In Vitro Photothermal Therapy

Author

Griaznova, Olga Yu., primary, Belyaev, Iaroslav B., additional, Sogomonyan, Anna S., additional, Zelepukin, Ivan V., additional, Tikhonowski, Gleb V., additional, Popov, Anton A., additional, Komlev, Aleksei S., additional, Nikitin, Petr I., additional, Gorin, Dmitry A., additional, Kabashin, Andrei V., additional, and Deyev, Sergey M., additional

Published
2022
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18. Laser synthesis of nanomaterials for nuclear nanomedicine

Author

Tikhonowski, Gleb V., primary, Popov, Anton A., additional, Zelepukin, Ivan, additional, Popova-Kuznetsova, Elena, additional, Dombrovska, Yaroslava I., additional, Deev, Sergey M., additional, Zavestovskaya, Irina N., additional, Klimentov, Sergey M., additional, Prasad, Paras N., additional, and Kabashin, Andrei V., additional

Published
2022
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20. Comparison of pharmacokinetics and biodistribution of laser-synthesized plasmonic Au and TiN nanoparticles

Author

Popov, Anton A, primary, Zelepukin, Ivan V, additional, Tikhonowski, Gleb V, additional, Popova-Kuznecova, Elena A, additional, Tselikov, Gleb I, additional, Al-Kattan, Ahmed, additional, Bailly, Anne-Laure, additional, Correard, Florian, additional, Braguer, Diane, additional, Esteve, Marie-Anne, additional, Klimentov, Sergey M, additional, Deyev, Sergey M, additional, and Kabashin, Andrei V, additional

Published
2021
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