33 results on '"Tiina, L."'
Search Results
2. Medico-legal autopsy in postoperative hemodynamic collapse following coronary artery bypass surgery
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Karhunen, Janne P., Karhunen, Pekka J., Raivio, Peter M., Sihvo, Eero I. T., Vainikka, Tiina L. S., and Salminen, Ulla-Stina
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- 2011
- Full Text
- View/download PDF
Catalog
3. Local C-Reactive Protein Expression in Obliterative Lesions and the Bronchial Wall in Posttransplant Obliterative Bronchiolitis
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Outi E. Päiväniemi, Paula K. Maasilta, Tiina L. S. Vainikka, Hanni S. Alho, Pekka J. Karhunen, and Ulla-Stina Salminen
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Pathology ,RB1-214 - Abstract
The local immunoreactivity of C-reactive protein (CRP) was studied in a heterotopic porcine model of posttranplant obliterative bronchiolitis (OB). Bronchial allografts and control autografts were examined serially 2–28 days after subcutaneous transplantation. The autografts stayed patent. In the allografts, proliferation of inflammatory cells (P more...
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- 2009
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4. In Situ Hybridization for Metalloproteinases and Their Inhibitors
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Hurskainen, Tiina L., primary and Apte, Suneel S., additional
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- 2010
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- View/download PDF
5. Long-term biocompatibility of a miniature stimulator implanted in feline hind limb muscles
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Cameron, Tracy, Liinamaa, Tiina L., Loeb, Gerald E., and Richmond, Frances J.R.
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Biocompatibility -- Research ,Electric stimulation -- Equipment and supplies ,Cats -- Physiological aspects ,Muscles -- Physiological aspects ,Paralysis -- Prevention ,Biological sciences ,Business ,Computers ,Health care industry - Published
- 1998
6. Immune cells in a heterotopic lamb-to-pig bronchial xenograft model
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Maasilta, Paula K., Vainikka, Tiina L. S., Alho, Hanni S., and Salminen, Ulla-Stina
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- 2005
7. ADAM-TS5, ADAM-TS6, and ADAM-TS7, Novel Members of a New Family of Zinc Metalloproteases: GENERAL FEATURES AND GENOMIC DISTRIBUTION OF THE ADAM-TS FAMILY
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Hurskainen, Tiina L., Hirohata, Satoshi, Seldin, Michael F., and Apte, Suneel S.
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- 1999
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8. Impact of smoking and smoking cessation on cardiovascular events and mortality among older adults: Meta-analysis of Individual participant data from prospective cohort studies of the CHANCES consortium
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Mons, U., Müezzinler, A., Gellert, C., Schöttker, B., Abnet, C. C., Bobak, M., De Groot, L., Freedman, N. D., Jansen, E., Kee, F., Kromhout, D., Kuulasmaa, K., Tiina, L., O'Doherty, M. G., Bas, B. -D. -M., Orfanos, P., Peters, A., Van Der Schouw, Y. T., Wilsgaard, T., Wolk, A., Trichopoulou, A., Boffetta, P., Brenner, H., Baceviciene, M., Boer, J. M. A., Drygas, W., Eriksson, S., Feskens, E., Gafarov, V., Gardiner, J., Håkansson, N., Jansson, J. -H., Jousilahti, P., Kampman, E., Kontto, J., Kubinova, R., Leenders, M., Linneberg, A., Løchen, M. -L., Lorbeer, R., Malyutina, S., Mathiesen, E. B., Melhus, H., Michaëlsson, K., Njølstad, I., Orsini, N., Pajak, A., Pikhart, H., Pisinger, C., Salomaa, V., Sánchez, M. -J., Sans, S., Schaan, B., Schneider, A., Siganos, G., Söderberg, S., Streppel, M., Tamošiunas, A., Veronesi, G., Waterham, E., Wennberg, P., Mons, U., Müezzinler, A., Gellert, C., Schöttker, B., Abnet, C.C., Bobak, M., De Groot, L., Freedman, N.D., Jansen, E., Kee, F., Kromhout, D., Kuulasmaa, K., Tiina, L., O'Doherty, M.G., Bas, B.-D.-M., Orfanos, P., Peters, A., Van Der Schouw, Y.T., Wilsgaard, T., Wolk, A., Trichopoulou, A., Boffetta, P., Brenner, H., Baceviciene, M., Boer, J.M.A., Drygas, W., Eriksson, S., Feskens, E., Gafarov, V., Gardiner, J., Håkansson, N., Jansson, J.-H., Jousilahti, P., Kampman, E., Kontto, J., Kubinova, R., Leenders, M., Linneberg, A., Løchen, M.-L., Lorbeer, R., Malyutina, S., Mathiesen, E.B., Melhus, H., Michaëlsson, K., Njølstad, I., Orsini, N., Pajak, A., Pikhart, H., Pisinger, C., Salomaa, V., Sánchez, M.-J., Sans, S., Schaan, B., Schneider, A., Siganos, G., Söderberg, S., Streppel, M., Tamošiunas, A., Veronesi, G., Waterham, E., and Wennberg, P. more...
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Medicine (all) ,Smoking - cardiovascular mortality - stroke - Abstract
OBJECTIVE: To investigate the impact of smoking and smoking cessation on cardiovascular mortality, acute coronary events, and stroke events in people aged 60 and older, and to calculate and report risk advancement periods for cardiovascular mortality in addition to traditional epidemiological relative risk measures. DESIGN: Individual participant meta-analysis using data from 25 cohorts participating in the CHANCES consortium. Data were harmonised, analysed separately employing Cox proportional hazard regression models, and combined by meta-analysis. RESULTS: Overall, 503 905 participants aged 60 and older were included in this study, of whom 37 952 died from cardiovascular disease. Random effects meta-analysis of the association of smoking status with cardiovascular mortality yielded a summary hazard ratio of 2.07 (95% CI 1.82 to 2.36) for current smokers and 1.37 (1.25 to 1.49) for former smokers compared with never smokers. Corresponding summary estimates for risk advancement periods were 5.50 years (4.25 to 6.75) for current smokers and 2.16 years (1.38 to 2.39) for former smokers. The excess risk in smokers increased with cigarette consumption in a dose-response manner, and decreased continuously with time since smoking cessation in former smokers. Relative risk estimates for acute coronary events and for stroke events were somewhat lower than for cardiovascular mortality, but patterns were similar. CONCLUSIONS: Our study corroborates and expands evidence from previous studies in showing that smoking is a strong independent risk factor of cardiovascular events and mortality even at older age, advancing cardiovascular mortality by more than five years, and demonstrating that smoking cessation in these age groups is still beneficial in reducing the excess risk. © 2015 BMJ Publishing Group Ltd. more...
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- 2015
9. Comparative study of sugar fermentation and protein expression patterns of two Lactobacillus plantarum strains grown in three different media
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Plumed-Ferrer, Carme, Koistinen, Kaisa M., Tolonen, Tiina L., Lehesranta, Satu J., Karenlampi, Sirpa O., Makimattila, Elina, Joutsjoki, Vesa, Virtanen, Vesa, and von Wright, Atte
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Lactobacillus plantarum -- Genetic aspects ,Lactobacillus plantarum -- Research ,Fermentation -- Research ,Lactic acid -- Research ,Sugar -- Production processes ,Biological sciences - Abstract
The protein expression patterns of Lactobacillus plantarum strains REB1 and MLBPL1 are examined with media that are relevant to the fermentation processed in which these strains are actually used as starters. The study has helped in understanding the mechanisms involved in the growth performance of an appropriate lactic acid bacterium strain used for food and feed fermentation, which is vital for obtaining a high-quality fermented product. more...
- Published
- 2008
10. Disappearance of malachite green residues in fry of rainbow trout (Oncorhynchus mykiss) after treatment of eggs at the hatching stage
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Erja Lindfors, Tiina L. Korkea-aho, Markku Tuomainen, Tapio Kiuru, Kirsi Niska, Kimmo Peltonen, and Jouni Taskinen
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Residue (complex analysis) ,Hatching ,Metabolite ,Aquatic animal ,Saprolegnia ,Aquatic Science ,Biology ,biology.organism_classification ,Leucomalachite green ,Fishery ,chemistry.chemical_compound ,Animal science ,chemistry ,Rainbow trout ,Malachite green - Abstract
The disappearance of malachite green (MG) residues was determined in fry of rainbow trout (Oncorhynchus mykiss) after six repeated treatments of the eggs at the hatching stage with MG oxalate at exposure levels of 1, 3 and 6 mg l− 1 for 30 min. Fry samples were taken from newly hatched fry (0 days post-hatch, d.p.h.) and at regular time intervals at 16, 31, 43, 57 and 96 d.p.h. The residues of MG and its major metabolite, leucomalachite green (LMG), were found to accumulate in the fry after MG treatments of eggs, with the highest residue levels being determined in the newly hatched fry. After exposures of 3 mg l− 1 MG, mean concentrations of 1170 ± 106 µg kg− 1 and 276 ± 38.6 µg kg− 1 (n = 3) were found in fry for LMG and MG, respectively. However, the disappearance of residues occurred rapidly in the fry, such that by 43 d.p.h. only low levels of LMG could be determined. To confirm the elimination of residues, determinations were made also in fry muscle at 96 d.p.h. but no residues were detected. The residues of MG in fry were determined by liquid chromatography-tandem mass spectrometric (LC-MS/MS) analysis with a limit of detection (LOD) of 0.5 µg kg− 1 and a limit of quantification (LOQ) of 1.0 µg kg− 1. The accumulation as well as the elimination of residues correlated well with the level of exposure. During the study, the fry increased their weight, such that at the end of the study, their mean body weight was about 150 times greater than the mean body weight of the newly hatched fry. As the disappearance of residues occurred in conjunction with the growth of fry, the present results indicate that no residues of MG will remain in the fish intended for human consumption, if MG treatment takes place at the hatching stage under controlled conditions. more...
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- 2009
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11. Factors affecting between-lake variation in the occurrence of epidermal papillomatosis in roach,Rutilus rutilus(L.)
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Jouni Taskinen, Tiina L. Korkea-aho, Raine Kortet, and Anssi Vainikka
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Male ,Insular biogeography ,Veterinary (miscellaneous) ,Biogeography ,Cyprinidae ,Drainage basin ,Fresh Water ,Aquatic Science ,Fish Diseases ,Altitude ,Risk Factors ,parasitic diseases ,Animals ,Colonization ,Analysis of Variance ,geography ,geography.geographical_feature_category ,Extinction ,Papilloma ,biology ,Ecology ,Discriminant Analysis ,Aquatic animal ,biology.organism_classification ,Skin Diseases, Viral ,Female ,Rutilus - Abstract
The theory of island biogeography predicts that the probability of a species occupying an island depends on a dynamic equilibrium between extinction and colonization. Epidermal papillomatosis is a disease manifesting as skin tumours on fish. We studied the factors affecting the occurrence of the disease in roach, Rutilus rutilus (L.), in 34 lakes. The results of discrimination analysis suggest that maximum depth, percentage of the drainage area of the lake covered by lakes in the vicinity and altitude best identified diseased lakes. Comparison of diseased and non-diseased lakes revealed that lake area could also be regarded as a variable contributing to the occurrence of the disease. The sampling date, proportion of males and mean length of fish did not discriminate between the lakes. The probability of the disease occurring was highest in large, deep, low-altitude lakes which had a high percentage of lakes in their vicinity. Thus, the results indicate that the colonization and extinction processes probably contribute to the occurrence of papillomatosis in roach, as predicted by the theory. Furthermore, the large natural variation in the occurrence of the disease could mask possible environmental effects and between-lake comparisons should be interpreted with caution when using the fish-papillomatosis system as an indicator of environmental stress. more...
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- 2009
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12. Association between environmental stress and epidermal papillomatosis of roach Rutilus rutilus
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Jouni Taskinen, Anssi Vainikka, V Kiviniemi, J M Partanen, and Tiina L. Korkea-aho
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Male ,Veterinary medicine ,Population ,Cyprinidae ,Papillomatosis ,Aquatic Science ,Environmental stress ,Fish Diseases ,Sex Factors ,Statistical analyses ,Prevalence ,medicine ,Animals ,education ,Finland ,Ecology, Evolution, Behavior and Systematics ,education.field_of_study ,Papilloma ,biology ,Ecology ,Environmental Exposure ,Environmental exposure ,biology.organism_classification ,Epidemiological Monitoring ,%22">Fish ,Female ,Epidermis ,medicine.symptom ,Rutilus ,Water Pollutants, Chemical ,Environmental Monitoring - Abstract
We studied the association between environmental stress and epidermal papillomatosis of roach Rutilus rutilus L. in Finnish waters using a 'matched pairs' design. Populations impacted by industrial and/or sewage effluents were compared to reference populations from pristine sites. We examined both the prevalence (proportion of diseased fish) and intensity (number of scales covered by tumors) of the disease. Results of Generalized Linear Mixed Models (GLMM) indicated that the risk of papillomatosis was 7.5 times higher in males than females, and increased 1.3 times for every 10 mm increment in fish length. We controlled for the possible effects of fish size, sex and temporal variation through sampling procedures and statistical analyses. Mean prevalence of epidermal papillomatosis was 16.6 and 5.8% in impact and reference populations, respectively (10 population pairs; nfish = 1714). Results of GLMM suggested that the risk of being diseased was 2.7 times higher in the impact than reference populations. Thus, the prevalence of epidermal papillomatosis in roach can be used as an indicator of environmental stress. Results of Linear Mixed Models indicated no difference in the intensity of the disease between impact and reference populations (5 population pairs; nfish = 73; mean+/-SE 10.7+/-1.8 and 11.7+/- 2.9 scales, respectively), although prevalence was higher in impact populations in those 5 population pairs. The possible relationship between environmental stress and intensity of epidermal papillomatosis in natural roach populations remains to be demonstrated. more...
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- 2006
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13. Biweekly docetaxel is better tolerated than conventional three-weekly dosing for advanced hormone-refractory prostate cancer
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Hervonen P, Joensuu H, Joensuu T, Ginman C, Claes G, Ray McDermott, Ray M, Harmenberg U, Ulrika H, Nyandoto P, Paul N, Luukkaala T, Tiina L, Hemminki A, Akseli H, Zaitsev I, Igor Z, Heikkinen M, Mirja H, Nilsson S, Sten N, Luukkaa M, Marjaanai L, Lehtinen I, Ilari L, Pl, Kellokumpu-Lehtinen, and Kl, Pirkko-Liisa more...
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Aged, 80 and over ,Male ,Neoplasms, Hormone-Dependent ,Humans ,Prostatic Neoplasms ,Taxoids ,Docetaxel ,Adenocarcinoma ,Middle Aged ,Antineoplastic Agents, Phytogenic ,Drug Administration Schedule ,Aged - Abstract
Docetaxel administered every three weeks is the standard treatment for advanced hormone-refractory prostate cancer (HRPC). However, biweekly administration might be better tolerated due to the reduced peak drug concentrations. Therefore, we compared biweekly to triweekly docetaxel as first- or second-line chemotherapy for advanced HRPC in this prospective randomized multicenter trial.In this study, 360 patients were randomly allocated to receive docetaxel 75 mg/m(2) i.v. d1 q3 weeks (tT) or 50 mg/m(2) i.v. d1 and d 14, q4 weeks (bT) from March 2004 to May 2009. Oral prednisolone (10 mg/day) was administered in both groups. The groups were well balanced according to the WHO performance status in terms of mean age (70 vs. 68, range 45-87 years) and median serum PSA level at the time of study entry (109 vs. 98 μg/l, range 11-1490 μg/l). The primary endpoint was time to treatment failure (TTF). ClinicalTrials.gov study identifier: NCT00255606.Ultimately, 158 patients (tT=79; bT=79) were included in this preplanned interim safety analysis; 567 and 487 cycles (equivalent to 1701 and 1948 weeks of treatment) were administered in the tT and bT groups, respectively. The most common grade 3-4 adverse events (expressed as %/cycles) in tT /bT were neutropenia 20%/14%; infection with/without neutropenia 8%/3%; fatigue 3%/3%; febrile neutropenia 2%/1%; and bone pain 2%/1%. Serious adverse events occurred more frequently in the group tT (n=60, 10.6% of cycles) than in the group bT (n=29, 6.0%, p=0.012). One patient died due to coronary infarction, and another was diagnosed with acute lymphocytic leukemia (both in the bT group). Thirty patients (38%) in the bT group and 22 patients (28%) in the tT group were still receiving treatment at 6 months (p=0.176).Biweekly docetaxel was tolerated better than conventional triweekly with fewer serious adverse events and more patients were still on the therapy at 6 months. Biweekly docetaxel therapy might be considered as an option for elderly patients exhibiting a compromised general condition. more...
- Published
- 2012
14. In situ hybridization for metalloproteinases and their inhibitors
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Tiina L, Hurskainen and Suneel S, Apte
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DNA, Complementary ,Tissue Fixation ,Ethanol ,Staining and Labeling ,Transcription, Genetic ,RNA Probes ,Templates, Genetic ,Immunohistochemistry ,Mice ,Ribonucleases ,Metalloproteases ,Animals ,Chemical Precipitation ,Enzyme Inhibitors ,Digoxigenin ,Cryoultramicrotomy ,In Situ Hybridization - Abstract
In situ hybridization (ISH) is an invaluable tool in understanding tissue-specific gene expression and gene regulation within a spatial context and at a resolution that is not possible by any other method. In this chapter, we provide ISH methodology that has successfully been applied to the detection of metalloproteinases and their inhibitors. more...
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- 2010
15. Outcome of aortic valve replacement with bioprostheses in the elderly
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Raili T, Suojaranta-Ylinen, Sari, Soisalon-Soininen, Maija, Kaartinen, Paula K, Maasilta, Tiina L, Vainikka, Antti E, Vento, and Ulla-Stina, Salminen
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Aged, 80 and over ,Bioprosthesis ,Heart Valve Prosthesis Implantation ,Male ,Treatment Outcome ,Heart Valve Prosthesis ,Humans ,Female ,Aortic Valve Stenosis ,Kaplan-Meier Estimate ,Middle Aged ,Aged - Abstract
Today, the elderly population continues to increase worldwide, and rates of aortic stenosis (AS) climb with age. Since aortic valve replacement (AVR) is the current treatment for elderly patients with symptomatic AS, the number of patients undergoing AVR is expected to grow.Among patients operated on at Helsinki University Hospital between 1992 and 1997, a cohort (n = 145) was followed after AVR with a bioprosthesis. The patients were allocated to three groups, based on their age at the time of surgery:or = 80 years (n = 30),80 toor = 70 years (n = 94), andor = 70 years (n = 21). All data relating to preoperative risk factors were collected. A control examination, which included echocardiography, was performed at least five years after surgery, and the follow up was continued until July 2006. The number of deaths and causes of death, as well as valve-related complications, were noted.The 30-day mortality rates were 3.3% in the oldest (or = 80-year) group, 6.4% in the middle (80 toor = 70-year) group, and zero in the youngest (or = 70-year) group. The mean age at death was 88 and 81 years in the oldest and middle groups, respectively. In the oldest and youngest groups, there were no reoperations, but five valve-related reoperations were performed during follow up in the middle group. At the control visit, the left ventricular ejection fraction was60% in all groups. In the oldest and middle groups the aortic valve gradient was lower than the preoperative level, while the left ventricular diameters and wall dimensions were smaller (p0.05). Valve calcification was observed in one patient in the youngest group.Elderly patients who had undergone AVR with a bioprosthesis had a good outcome after more than 10 years of follow up, with an improved cardiac function being preserved for at least seven years after surgery. Despite a severely impaired preoperative aortic valve function, octogenarians especially had a good life expectancy, possibly due to their low comorbidity rates. Hence, AVR with a bioprosthesis proved to be an excellent treatment in this patient group. more...
- Published
- 2010
16. Comparative study of sugar fermentation and protein expression patterns of two Lactobacillus plantarum strains grown in three different media
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Carme Plumed-Ferrer, Kaisa M. Koistinen, Tiina L. Tolonen, Satu J. Lehesranta, Sirpa O. Kärenlampi, Elina Mäkimattila, Vesa Joutsjoki, Vesa Virtanen, and Atte von Wright
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Proteomics ,Animal feed ,Colony Count, Microbial ,Malates ,Bacterial growth ,Applied Microbiology and Biotechnology ,chemistry.chemical_compound ,food ,Tandem Mass Spectrometry ,Electrophoresis, Gel, Two-Dimensional ,Lactic Acid ,Sugar ,Acetic Acid ,Hexoses ,Principal Component Analysis ,Ecology ,biology ,Cucumber juice ,Lactobacillaceae ,biology.organism_classification ,Adaptation, Physiological ,Animal Feed ,food.food ,Lactic acid ,Culture Media ,chemistry ,Biochemistry ,Fermentation ,Food Microbiology ,Lactobacillus plantarum ,Food Science ,Biotechnology ,Chromatography, Liquid - Abstract
A comparative study of two strains of Lactobacillus plantarum (REB1 and MLBPL1) grown in commercial medium (MRS broth), cucumber juice, and liquid pig feed was performed to explore changes to the metabolic pathways of these bacteria, using a proteomics approach (two-dimensional electrophoresis and liquid chromatography-tandem mass spectrometry) combined with analyses of fermentable sugars and fermentation end products. The protein expression showed that even with an excess of glucose in all media, both strains could metabolize different carbohydrates simultaneously and that hexoses could also be used via a phosphoketolase pathway with preferential expression in liquid feed. Sugar analyses showed that the fermentation of sugars was homolactic for all media, with some heterolactic activity in liquid feed, as shown by the production of acetate. Cucumber juice (the medium with the highest glucose content) showed the lowest hexose consumption (10%), followed by liquid feed (33%) and MRS broth (50%). However, bacterial growth was significantly higher in cucumber juice and liquid feed than in MRS broth. This discrepancy was due to the growth benefit obtained from the utilization of the malate present in cucumber juice and liquid feed. Despite different growth conditions, the synthesis of essential cellular components and the stress response of the bacteria were unaffected. This study has improved our understanding of the mechanisms involved in the growth performance of an appropriate lactic acid bacterium strain to be used for food and feed fermentation, information that is of crucial importance to obtain a high-quality fermented product. more...
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- 2008
17. Hypoxia increases intensity of epidermal papillomatosis in roach Rutilus rutilus
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Jouni Taskinen, Tiina L. Korkea-aho, Janne M. Partanen, and Jussi V. K. Kukkonen
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Papilloma ,Ecology ,Environmental factor ,Cyprinidae ,Temperature ,Physiology ,Hypoxia (environmental) ,Fresh Water ,Oxygen deficiency ,Papillomatosis ,Aquatic Science ,Biology ,medicine.disease_cause ,biology.organism_classification ,Environmental stress ,Oxygen ,Fish Diseases ,medicine ,Animals ,Rutilus ,medicine.symptom ,Eutrophication ,Hypoxia ,Ecology, Evolution, Behavior and Systematics - Abstract
Hypoxia, which occurs frequently in aquatic ecosystems and is mainly due to increasing eutrophication can cause severe environmental stress in fish. We investigated experimentally the hypothesis that hypoxia could be one of the environmental stress factors that can induce papillomatosis in fish. Male roach Rutilus rutilus exposed to periodic oxygen deficiency and accompanied temperature increases (OT group) showed the highest increase in the intensity of papillomatosis, as measured by the number of scales covered by papillomatosis tumors. The second highest increase in disease intensity was among male roach exposed to periodical temperature increases. The incidence of such tumors was lowest in the control group, which was exposed to neither hypoxia nor increased temperature. The mortality of fish during the 17 d experiment was highest and the condition factor was lowest in the OT group, indicating this group experienced a higher level of stress. The apparent interaction of hypoxia and temperature suggests that these environmental stressors are among the multifactorial elements leading to papillomatosis in roach. Furthermore, these results provide experimental evidence to indicate that hypoxia may contribute to tumor development in fish. more...
- Published
- 2008
18. The effects of treated effluents on the intensity of papillomatosis and HSP70 expression in roach
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Jussi V. K. Kukkonen, Eeva-Riikka Vehniäinen, Jouni Taskinen, and Tiina L. Korkea-aho
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Gills ,Male ,Paper ,Veterinary medicine ,ympäristö ,pulp mill effluents ,sex difference ,Health, Toxicology and Mutagenesis ,heat shock protein ,Cyprinidae ,Industrial Waste ,Papillomatosis ,Environmental stress ,Waste Disposal, Fluid ,medicine ,ihokasvaintauti ,Animals ,municipal effluents ,HSP70 Heat-Shock Proteins ,Water Pollutants ,papilloma disease ,särki ,papillomatoosi ,Effluent ,HSP70 ,Hsp70 expression ,biology ,Papilloma ,Ecology ,digestive, oral, and skin physiology ,Environmental stressor ,Public Health, Environmental and Occupational Health ,stressi ,General Medicine ,biology.organism_classification ,Pollution ,environmental stress ,altistuminen ,%22">Fish ,Female ,medicine.symptom ,Rutilus ,jätevedet ,Waste disposal - Abstract
Epidermal papillomatosis in fish has been proposed as an indicator of environmental stress but experimental evidence of connection between contaminants and papillomatosis in fish is scarce. We studied changes in the intensity of epidermal papillomatosis and the expression of heat shock protein 70 (HSP70) in roach, Rutilus rutilus, exposed to treated pulp mill and municipal effluents. In male roach, the increase in papillomatosis intensity was higher in fish exposed to 15% than in fish exposed to 1.5% concentration of municipal effluent. No differences were observed in papillomatosis development in females, or in HSP70 expression. In all the experiments conducted, the increasing effect of effluents seemed to be more pronounced in male fish suggesting that sex-related factors affected the intensity of papillomatosis after exposure to effluents. The present results indicate that environmentally relevant concentrations of municipal effluents may be contributing to the development of papillomatosis in fish. peerReviewed more...
- Published
- 2007
19. Synthesis and CB1 receptor activities of novel arachidonyl alcohol derivatives
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Jukka Gynther, Tapio Nevalainen, Tiina L. Tolonen, Jarmo T. Laitinen, Tomi Järvinen, Juha R. Savinainen, Teija Parkkari, and Anu L. Rauhala
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Male ,Cannabinoid receptor ,Stereochemistry ,medicine.medical_treatment ,Clinical Biochemistry ,Pharmaceutical Science ,Alcohol ,Arachidonic Acids ,Biochemistry ,Chemical synthesis ,chemistry.chemical_compound ,Receptor, Cannabinoid, CB1 ,Drug Discovery ,medicine ,Animals ,Rats, Wistar ,Molecular Biology ,Dose-Response Relationship, Drug ,Organic Chemistry ,Biological activity ,Rats ,Membrane ,nervous system ,chemistry ,Alcohols ,Molecular Medicine ,Cannabinoid - Abstract
Novel derivatives of arachidonyl alcohol were synthesized and evaluated for their CB1 receptor activity by [35S]GTPγS assay using rat cerebellar membranes.
- Published
- 2003
20. Medico-legal autopsy in postoperative hemodynamic collapse following coronary artery bypass surgery
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Karhunen, Janne P., primary, Karhunen, Pekka J., additional, Raivio, Peter M., additional, Sihvo, Eero I. T., additional, Vainikka, Tiina L. S., additional, and Salminen, Ulla-Stina, additional
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- 2010
- Full Text
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21. Local C-Reactive Protein Expression in Obliterative Lesions and the Bronchial Wall in Posttransplant Obliterative Bronchiolitis
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Päiväniemi, Outi E., primary, Maasilta, Paula K., additional, Vainikka, Tiina L. S., additional, Alho, Hanni S., additional, Karhunen, Pekka J., additional, and Salminen, Ulla-Stina, additional
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- 2009
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22. Usability Evaluation of Web Mapping Sites
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Nivala, Annu-Maaria, primary, Brewster, Stephen, additional, and Sarjakoski, Tiina L., additional
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- 2008
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23. User Aspects of Adaptive Visualization for Mobile Maps
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Nivala, Annu-Maaria, primary and Sarjakoski, Tiina L., additional
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- 2007
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24. Synthesis and CB1 receptor activities of novel arachidonyl alcohol derivatives
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Parkkari, Teija, primary, Savinainen, Juha R., additional, Rauhala, Anu L., additional, Tolonen, Tiina L., additional, Nevalainen, Tapio, additional, Laitinen, Jarmo T., additional, Gynther, Jukka, additional, and Järvinen, Tomi, additional more...
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- 2004
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25. Relationships between range of motion, Lo, and passive force in five strap-like muscles of the feline hind limb
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Brown, Ian E., primary, Liinamaa, Tiina L., additional, and Loeb, Gerald E., additional
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- 1996
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26. Bronchial artery revascularization improves tracheal anastomotic healing after lung transplantation.
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Hyytinen, Timo A., Heikkilä, Lasse J., Verkkala, Kalervo A., Sipponen, Jorma T., Vainikka, Tiina L. S., Halme, Maija, Hekali, Pauli E., Keto, Pekka E., Mattila, Severi P., Hyytinen, T A, Heikkilä, L J, Verkkala, K A, Sipponen, J T, Vainikka, T L, Halme, M, Hekali, P E, Keto, P E, and Mattila, S P more...
- Subjects
LUNG transplantation ,BRONCHIAL blood vessels ,BRONCHIOLES ,INFLAMMATION ,TRACHEAL surgery ,BRONCHI ,COMPARATIVE studies ,RESEARCH methodology ,MEDICAL cooperation ,RESEARCH ,SURGICAL complications ,WOUND healing ,EVALUATION research ,SURGICAL anastomosis ,BRONCHIAL arteries - Abstract
The study aimed to clarify the role of direct bronchial artery revascularization (BAR) after en bloc double-lung (DLT) and heart-lung transplantation (HLT). Group I comprised eight patients with en bloc DLT or HLT and successful BAR, while group II included 14 DLT or HLT cases without BAR or with failed BAR. From these groups, 2 subgroups were extracted: group III, including 6 cases of en bloc DLT with successful BAR and group IV 10 HLT cases without or with failed BAR. Airway healing was evaluated at bronchoscopy and patency of BAR with angiography. Pulmonary viral, bacterial and fungal infections, rejections and bronchiolitis obliterans syndrome (BOS) were registered. Tracheal healing at 2 weeks and 3 months was better in group I than in group 1 (p = 0.003 and p = 0.05, respectively). Compared with group IV, tracheal anastomotic healing at 2 weeks was better in group III (p = 0.007) and tended to be better also after 3 months (p = 0.07). The incidence of infections, rejection or BOS did not differ between groups I and II. BAR thus improved healing of tracheal anastomosis. [ABSTRACT FROM AUTHOR] more...
- Published
- 2000
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27. Post-Concussion Acute Signs and Reliable Cognitive Decline in a Finnish Youth Ice Hockey Sample.
- Author
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Kati P, Matti V, Sanna K, Jon P, Tiina L, and Laura H
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- Adolescent, Adult, Finland, Humans, Male, Neuropsychological Tests, Reproducibility of Results, Young Adult, Athletic Injuries complications, Brain Concussion complications, Brain Concussion diagnosis, Cognitive Dysfunction diagnosis, Cognitive Dysfunction etiology, Hockey
- Abstract
Objective: In sports concussion research, the importance of an individualized approach incorporating neuropsychological assessment data has been emphasized. This study examined the impact of acute signs of concussion on post-injury cognitive functioning using reliable change methodology in a sample of Finnish, elite-level, youth ice hockey players., Methods: From a sample of 1,823 players (all male, 14-20 years old) who completed preseason baseline testing with the Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT®) battery, two subgroups were identified. First, in total, 312 uninjured athletes, who completed baseline testing twice-1 year apart. The scores were contrasted to calculate reliable change indices (RCIs). Second, from a subsample of 570 athletes participating in an intensive follow-up arm of the project, the analysis included 32 concussed athletes. The RCIs were determined for the five ImPACT composite scores and used in identifying athletes with declined performance 3 days post-injury., Results: Test-retest reliability ranged from .39 to .71. Athletes who had experienced an acute loss of consciousness, amnesia, or postural instability had increased odds for declines in two or more areas assessed by ImPACT (odds ratio = 7.67-8.00, p < .05). In contrast, acute disorientation or vacant look did not lead to cognitive change that met the reliable change threshold., Conclusions: The reliability coefficients and RCIs differed from those published earlier emphasizing the importance of national reference values. The presence of acute loss of consciousness, amnesia, or postural instability may indicate a more severe injury and predict the need for more intensive cognitive follow-up., (© The Author(s) 2020. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.) more...
- Published
- 2021
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28. Corrigendum to: Post Concussion Acute Signs and Reliable Cognitive Decline in a Finnish Youth Ice Hockey Sample.
- Author
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Kati P, Matti V, Sanna K, Jon P, Tiina L, and Laura H
- Published
- 2021
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29. Risk for placental abruption following amniocentesis and chorionic villus sampling.
- Author
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Minna T, Mika G, Tiina L, Marjo M, Sture A, Olavi Y, Annukka R, Vilho H, Jorma P, and Mika N
- Subjects
- Abruptio Placentae epidemiology, Amniocentesis statistics & numerical data, Case-Control Studies, Chorionic Villi Sampling statistics & numerical data, Cohort Studies, Female, Humans, Maternal Age, Pregnancy, Pregnancy Complications epidemiology, Pregnancy, Multiple physiology, Pregnancy, Multiple statistics & numerical data, Risk Factors, Abruptio Placentae etiology, Amniocentesis adverse effects, Chorionic Villi Sampling adverse effects
- Published
- 2011
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30. In situ hybridization for metalloproteinases and their inhibitors.
- Author
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Hurskainen TL and Apte SS
- Subjects
- Animals, Chemical Precipitation, Cryoultramicrotomy, DNA, Complementary genetics, Digoxigenin metabolism, Ethanol, Immunohistochemistry, Metalloproteases antagonists & inhibitors, Metalloproteases metabolism, Mice, RNA Probes metabolism, Ribonucleases metabolism, Staining and Labeling, Templates, Genetic, Tissue Fixation, Transcription, Genetic, Enzyme Inhibitors metabolism, In Situ Hybridization methods, Metalloproteases genetics
- Abstract
In situ hybridization (ISH) is an invaluable tool in understanding tissue-specific gene expression and gene regulation within a spatial context and at a resolution that is not possible by any other method. In this chapter, we provide ISH methodology that has successfully been applied to the detection of metalloproteinases and their inhibitors. more...
- Published
- 2010
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31. Outcome of aortic valve replacement with bioprostheses in the elderly.
- Author
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Suojaranta-Ylinen RT, Soisalon-Soininen S, Kaartinen M, Maasilta PK, Vainikka TL, Vento AE, and Salminen US
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- Aged, Aged, 80 and over, Aortic Valve Stenosis mortality, Female, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Treatment Outcome, Aortic Valve Stenosis surgery, Bioprosthesis, Heart Valve Prosthesis, Heart Valve Prosthesis Implantation
- Abstract
Background and Aim of the Study: Today, the elderly population continues to increase worldwide, and rates of aortic stenosis (AS) climb with age. Since aortic valve replacement (AVR) is the current treatment for elderly patients with symptomatic AS, the number of patients undergoing AVR is expected to grow., Methods: Among patients operated on at Helsinki University Hospital between 1992 and 1997, a cohort (n = 145) was followed after AVR with a bioprosthesis. The patients were allocated to three groups, based on their age at the time of surgery: > or = 80 years (n = 30), < 80 to > or = 70 years (n = 94), and < or = 70 years (n = 21). All data relating to preoperative risk factors were collected. A control examination, which included echocardiography, was performed at least five years after surgery, and the follow up was continued until July 2006. The number of deaths and causes of death, as well as valve-related complications, were noted., Results: The 30-day mortality rates were 3.3% in the oldest (> or = 80-year) group, 6.4% in the middle (< 80 to > or = 70-year) group, and zero in the youngest (< or = 70-year) group. The mean age at death was 88 and 81 years in the oldest and middle groups, respectively. In the oldest and youngest groups, there were no reoperations, but five valve-related reoperations were performed during follow up in the middle group. At the control visit, the left ventricular ejection fraction was > 60% in all groups. In the oldest and middle groups the aortic valve gradient was lower than the preoperative level, while the left ventricular diameters and wall dimensions were smaller (p < 0.05). Valve calcification was observed in one patient in the youngest group., Conclusion: Elderly patients who had undergone AVR with a bioprosthesis had a good outcome after more than 10 years of follow up, with an improved cardiac function being preserved for at least seven years after surgery. Despite a severely impaired preoperative aortic valve function, octogenarians especially had a good life expectancy, possibly due to their low comorbidity rates. Hence, AVR with a bioprosthesis proved to be an excellent treatment in this patient group. more...
- Published
- 2009
32. Epithelial tenascin predicts obliterative airway disease.
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Päiväniemi OE, Maasilta PK, Alho HS, Vainikka TL, and Salminen US
- Subjects
- Animals, Bronchi pathology, Bronchiolitis Obliterans pathology, Bronchitis etiology, Bronchitis pathology, Cell Proliferation, Fibroblasts pathology, Fibrosis, Immunohistochemistry, Organ Transplantation adverse effects, Postoperative Period, Predictive Value of Tests, Respiratory Mucosa pathology, Swine, Time Factors, Transplantation, Homologous, Bronchi metabolism, Bronchi transplantation, Bronchiolitis Obliterans etiology, Postoperative Complications, Respiratory Mucosa metabolism, Tenascin metabolism
- Abstract
Background: Epithelial cell injury, inflammation, fibrosis and airway obliteration result in remodeling of terminal bronchi in post-transplant obliterative bronchiolitis. Tenascin as an extracellular matrix glycoprotein is expressed in several remodeling processes., Methods: Heterotopic bronchial allografts of pigs were studied to assess tenascin expression during development of post-transplant obliterative bronchiolitis. A total of 157 allografts or autograft controls were serially obtained 2 to 28 days after transplantation and processed for histology and immunocytochemistry for tenascin, CD4, CD8 and macrophages. Epithelial tenascin index was calculated by multiplying the percentage of positive cells by the grade of tenascin intensity (1 to 3)., Results: Epithelial tenascin expression occurred during the initial ischemic damage to the respiratory epithelium. After partial recovery and before total epithelial loss and subsequent airway obliteration, tenascin expression peaked in allografts (p < 0.001). Epithelial tenascin index on Day 7 was predictive of subsequent epithelial damage, bronchial wall inflammation and the number of (CD4(+) and CD8(+)) cells, fibroproliferation, and obliteration of the bronchial lumen (R > or = 0.47, p < or = 0.01). Tenascin expression in the bronchial wall was more intense in allografts (p < 0.001), paralleling proliferation of fibroblasts and influx of inflammatory cells, and was predictive of inflammatory alterations also in the early obliterative lesions (R > or = 0.45, p < 0.05). Expression decreased during maturation of fibrosis (p < 0.05)., Conclusions: Epithelial tenascin was predictive of features observed in post-transplant obliterative bronchiolitis, demonstrating a role for tenascin in the development of obliterative bronchiolitis. Tenascin may have relevant properties in serving as a clinical marker for early obliterative bronchiolitis. more...
- Published
- 2008
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33. Hypoxia increases intensity of epidermal papillomatosis in roach Rutilus rutilus.
- Author
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Korkea-aho TL, Partanen JM, Kukkonen JV, and Taskinen J
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- Animals, Fish Diseases mortality, Fresh Water, Hypoxia complications, Hypoxia physiopathology, Oxygen analysis, Papilloma complications, Papilloma mortality, Temperature, Cyprinidae, Fish Diseases pathology, Hypoxia veterinary, Papilloma pathology, Papilloma veterinary
- Abstract
Hypoxia, which occurs frequently in aquatic ecosystems and is mainly due to increasing eutrophication can cause severe environmental stress in fish. We investigated experimentally the hypothesis that hypoxia could be one of the environmental stress factors that can induce papillomatosis in fish. Male roach Rutilus rutilus exposed to periodic oxygen deficiency and accompanied temperature increases (OT group) showed the highest increase in the intensity of papillomatosis, as measured by the number of scales covered by papillomatosis tumors. The second highest increase in disease intensity was among male roach exposed to periodical temperature increases. The incidence of such tumors was lowest in the control group, which was exposed to neither hypoxia nor increased temperature. The mortality of fish during the 17 d experiment was highest and the condition factor was lowest in the OT group, indicating this group experienced a higher level of stress. The apparent interaction of hypoxia and temperature suggests that these environmental stressors are among the multifactorial elements leading to papillomatosis in roach. Furthermore, these results provide experimental evidence to indicate that hypoxia may contribute to tumor development in fish. more...
- Published
- 2008
- Full Text
- View/download PDF
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