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25 results on '"Tiesinga, James"'

6. Impact of Social Distancing and Travel Restrictions on non-COVID-19 Respiratory Hospital Admissions in Young Children in Rural Alaska

Author

Nolen, Leisha D, Seeman, Sara, Bruden, Dana, Klejka, Joe, Desnoyers, Chris, Tiesinga, James, and Singleton, Rosalyn

Subjects
AcademicSubjects/MED00290, Respiratory illness, Brief Report, RSV, Social Distancing, travel restriction
Abstract

Hospitalizations due to non-COVID-19 respiratory illnesses decreased dramatically after social distancing was implemented in a high-risk population in rural Alaska. Our data from the past ten respiratory seasons show that this decline is unprecedented. This demonstrates the potential secondary benefits of implementing social distancing and travel restrictions on respiratory illnesses.

Published
2020

13. Impact of Social Distancing and Travel Restrictions on Non–Coronavirus Disease 2019 (Non–COVID-19) Respiratory Hospital Admissions in Young Children in Rural Alaska.

Author

Nolen, Leisha D, Seeman, Sara, Bruden, Dana, Klejka, Joe, Desnoyers, Chris, Tiesinga, James, and Singleton, Rosalyn

Subjects
PREVENTION of infectious disease transmission, TRAVEL, RURAL conditions, RESPIRATORY infections, HOSPITAL care of newborn infants, HOSPITAL care, AT-risk people, SOCIAL distancing, RESPIRATORY syncytial virus infections, HOSPITAL care of children, INFECTIOUS disease transmission, CHILDREN
Abstract

Hospitalizations due to non-coronavirus disease 2019 (non-COVID-19) respiratory illnesses decreased dramatically after social distancing was implemented in a high-risk population in rural Alaska; an unprecedented decline compared to the past 10 respiratory seasons. This demonstrates the potential secondary benefits of implementing social distancing and travel restrictions on respiratory illnesses. [ABSTRACT FROM AUTHOR]

Published
2021
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14. Rickets and vitamin D deficiency in Alaska native children

Author

Singleton, Rosalyn, primary, Lescher, Rachel, additional, Gessner, Bradford D., additional, Benson, Matthew, additional, Bulkow, Lisa, additional, Rosenfeld, John, additional, Thomas, Timothy, additional, Holman, Robert C., additional, Haberling, Dana, additional, Bruce, Michael, additional, Bartholomew, Michael, additional, and Tiesinga, James, additional

Published
2015
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15. Su1213 Stool DNA Testing for Screen-Detection of Colorectal Neoplasia in Alaska Native People

Author

Redwood, Diana, primary, Asay, Elvin D., additional, Sacco, Pam, additional, Hamlin, Cindy E., additional, Otto, Evon, additional, Christensen, Claudia, additional, Davis, Paul W., additional, Tiesinga, James J., additional, Sacco, Frank D., additional, Devens, Mary E., additional, Alberts, Steven R., additional, Mahoney, Douglas W., additional, Fiero, Mallorie H., additional, Yab, Tracy C., additional, Lidgard, Graham P., additional, Berger, Barry M., additional, Provost, Ellen, additional, and Ahlquist, David A., additional

Published
2014
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16. HPV genotypes detected in cervical cancers from Alaska Native women, 1980–2007

Author

Kelly, Janet J., primary, Unger, Elizabeth R., additional, Dunne, Eileen F., additional, Murphy, Neil, additional, Tiesinga, James, additional, Koller, Kathy R., additional, Swango-Wilson, Amy, additional, Philemonof, Dino, additional, Lounmala, Xay, additional, Markowitz, Lauri E., additional, Steinau, Martin, additional, and Hennessy, Thomas, additional

Published
2013
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21. Risk-Based Prenatal Hepatitis C Testing Practices and Results, Alaska 2013-2016

Author

D. Nolen, Leisha, Gustin, Courtney, Seeman, Sara, Murphy, Neil, Truitt, Sarah, Schillie, Sarah, G. Bruce, Michael, Bruden, Dana, Tiesinga, James, and McMahon, Brian

Abstract

Hepatitis C virus (HCV) infection in pregnant women is of concern as it presents a health threat not only to the mother, but also to her infant. A retrospective analysis was performed to evaluate HCV testing and exposure in women who delivered infants between 2013 and 2016 at a referral hospital in Alaska. Multiple risk behaviors were evaluated, including drug dependency or abuse (drug abuse), tobacco use, alcohol dependency or abuse, and late presentation to prenatal care. Of the 2856 women who delivered between 2013 and 2016, 470 (16.5%) were tested for HCV during pregnancy and 1356 (47.5%) were tested at any time prior to delivery (including pregnancy); 62 (2.2%) were positive for HCV antibodies. Of the 162 women with a documented history of drug abuse, 95 (58.6%) were tested for HCV during pregnancy and 143 (88.3%) were tested at any time prior to delivery (including pregnancy); 30 (18.5%) were positive for HCV antibodies. Forty-nine women (34%) with a documented history of drug abuse who were not previously known to be HCV positive were not tested for HCV during their pregnancy. In conclusion, approximately 2% of pregnant women in the study population were known to have been exposed to HCV by the time of their delivery. One-third of women with documented drug abuse did not have an HCV test during pregnancy, revealing gaps in HCV testing of pregnant women. Further studies are needed to understand the full costs and benefits of risk-based screening versus universal screening in this and other populations.

Published
2019
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23. HPV genotypes detected in cervical cancers from Alaska Native women, 1980-2007.

Author

Kelly, Janet J., Unger, Elizabeth R., Dunne, Eileen F., Murphy, Neil J., Tiesinga, James, Koller, Kathy R., Swango-Wilson, Amy, Philemonof, Dino, Lounmala, Xay, Markowitz, Lauri E., Steinau, Martin, and Hennessy, Thomas

Subjects
*ALASKA Natives, *CERVICAL cancer, *INDIGENOUS women, *GENOTYPES, *CANCER
Abstract

Background. Human papillomavirus (HPV) vaccine prevents cervical pre-cancers and cancers caused by HPV types 16 and 18. This study provides information on the HPV types detected in cervical cancers of Alaska Native (AN) women. Methods. Cases of invasive cervical cancer diagnosed in AN women aged 18 and above between 1980 and 2007 were identified from the Alaska Native Tumor Registry. A representative formalin-fixed, paraffinembedded archived pathology block was retrieved and serially sectioned to allow histologic confirmation of lesion (first and last sections) and PCR testing of intervening sections. Extracted DNA was tested for HPV using Linear Array HPV Genotyping Test (Roche Diagnostics) with additional INNO-LiPA HPV Genotyping Assay (Innogenetics) testing on negative or inadequate specimens. All specimens were tested for a minimum 37 HPV types. Results. Of 62 cervical cancer specimens evaluated, 57 (91.9%) contained one or more HPV types. Thirty-eight (61.2%) cancers contained HPV types 16 or 18, and 18 (29%) contained an oncogenic type other than type 16 or 18. Conclusions. Overall, almost two-thirds (61.2%) of the archived cervical cancers had detectible HPV types 16 or 18, a finding similar to studies of US women. As expected, a proportion of cancers would not be prevented by the current vaccines. HPV vaccination and cervical cancer screening are important prevention strategies for AN women. [ABSTRACT FROM AUTHOR]

Published
2013
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24. Case report: Primary vulvar adenocarcinoma of mammary gland type-its genetic characteristics by focused next-generation sequencing.

Author

Hu L and Tiesinga J

Subjects
Female, Humans, Middle Aged, Breast pathology, High-Throughput Nucleotide Sequencing, Mammary Glands, Human metabolism, Mammary Glands, Human pathology, Adenocarcinoma pathology, Vulvar Neoplasms genetics, Vulvar Neoplasms metabolism, Vulvar Neoplasms pathology
Abstract

Mammary-like vulvar adenocarcinoma (MLVA) is an exceedingly rare subtype of vulvar adenocarcinoma that shares features with mammary gland tissue. Due to its rarity and lack of consensus, MLVA presents diagnostic challenges to pathologists. We present the case of a 59-year-old female with an ulcerated mass on the right side of the external genitalia, diagnosed as MLVA. Comprehensive immunohistochemistry (IHC) and gene sequencing studies were performed to characterize the tumor. IHC analysis revealed triple expression of hormonal receptors (estrogen receptor, progesterone receptor, and HER2), supporting the mammary gland origin of the tumor. Gene sequencing identified unique genetic mutations associated with the expression of hormonal markers. One fusion gene (ERBB2-NAGLU) has not been reported in any tumors, and other mutations with unique mutation types have not been previously reported in MLVA. Our findings shed light on the molecular characteristics of MLV and may help improve the diagnosis and treatment of this rare type of vulvar adenocarcinoma., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Hu and Tiesinga.)

Published
2024
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25. RSV Among American Indian and Alaska Native Children: 2019 to 2020.

Author

Atwell JE, Hartman RM, Parker D, Taylor K, Brown LB, Sandoval M, Ritchie N, Desnoyers C, Wilson AS, Hammes M, Tiesinga J, Halasa N, Langley G, Prill MM, Bruden D, Close R, Moses J, Karron RA, Santosham M, Singleton RJ, and Hammitt LL

Subjects
Child, Humans, United States epidemiology, American Indian or Alaska Native, Respiratory Syncytial Virus Infections epidemiology
Published
2023
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