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As agreed with the officer, this deliverable contains both the exploitation plan and the final market analysis. This was necessary to ensure that all relevant commercial information is kept confidential. Consequently the deliverable is divided in two parts. The first part (chapter 1) contains the exploitation plan. The second part (chapter 2&3) contains the market analysis The last part are the conclusions We also added an appendix to describe briefly the possible related MEMS activity to be synergic with MINEON -OS

We report the use of an electrostatic MEMS-based device to produce high quality electron vortex beams with more than 1000 quanta of orbital angular momentum (OAM). Diffraction and off-axis electron holography experiments are used to show that the diameter of the vortex in the diffraction plane increases linearly with OAM, thereby allowing the angular momentum content of the vortex to be calibrated. The realization of electron vortex beams with even larger values of OAM is currently limited by the breakdown voltage of the device. Potential solutions to overcome this problem are discussed.

MEMS based electron optics are a promising approach for a new generation of experiments in electron microscopy. In this contribution we improve analytically the modelling of the MEMS based phase plates with thin electrodes with accurate account of the fringing fields. As a result we are able to improve the design and the boundary conditions in MEMS-based spiral phase plates acting on the control parameters. We checked the quality of the generated vortex beam.

This deliverable itemises and details the elements for MINEON products and defines the prospective costs as a function of the production volumes. In the first chapter the MINEON product is described in general. In the second chapter the items are described to a better level of detail making also a comparison with potentially similar products on the market. In the third chapter the costs are discussed in detail in different scenarios. In the final chapter the conclusions are drawn.

In quantum mechanics, each conserved quantity (e.g., energy, position, linear momentum and angular momentum) is associated with a Hermitian operator. Its expected value can then be determined by performing a measurement on the wavefunction. In modern electron microscopy, one can select the initial and final states of the electron and the measurement basis by performing measurements of scattering processes. For example, the orbital angular momentum (OAM) of an electron can be used to reveal the n-fold symmetry of a wavefunction scattered by a sample. Here, we introduce a new composite planar chirality operator that can be used to measure a spiral-like feature in a sample. This concept develops the concept of chirality to highlight a specific roto-scale symmetry. We show that planar chirality can be characterized using an electron OAM sorter to uncover the atomic structures of biomolecules in cryo electron microscopy, either in a stand-alone analysis for fast identification of protein structures or in the context of conventional cryo electron microscopy to produce faster and more detailed 3D reconstructions by solving upside-down orientation ambiguities., available also at arXiv:2110.03391 This project has received fundings also from the Deutsche Forschungsgemeinschaft (Project-ID 405553726 – TRR 270), from the DARPA TEE program (Grant MIPR# HR0011831554) and from an Ontario Early Researcher Award (ERA) and a Canada Research Chair (CRC).

The purpose of this deliverable is 1) to describe the new software for the gaussian ray tracing of electrons inside the microscope. 2) to describe its application to describe the sorting experiments. In particular this deliverable describes the features that have been implemented in the software and how to use the code to predict the behavior of the electronic column. The long term objective is to set the best parameters for the phase element of the OAM sorter and guarantee the successful operation without need of further adjustments in the fabrication but also a guide to the actual experiments since the microscope must be operated in non-standard conditions.

The purpose of this deliverable is to collect the documents related to the QSORT First Review Meeting, which was held in Brussels on 14 December 2019. This deliverable complies with the QSORT description of work outlined in Work Package 1, Project management, and it particularly satisfies the specifications outlined in T1.1 regarding reporting, and T1.2, regarding the quality assurance. It is intended to benefit the work of the following interrelated tasks: T1.1 General project management; T1.2 Quality Assurance & RRI Compliance; and in general for all the project workpackages. The current document comprises an Executive Summary and four main sections. The first section (p.8) contains the Publishable Summary prepared for QSORT. The second section (p.16) describes the Project progress as detailed in the Technical Report submitted to the European Commission, including an outline of the Quality Assurance (QA) methodologies that have been put in place to monitor Project progress, the resource usage, and the process that has been set up to ensure a timely and highquality delivery of all the Project’s results and deliverables. The third section (p.153) collects the programme and the presentations of QSORT’s First Review Meeting. The fourth section (p.311) summarises the results of the survey run amongst the project partners to selfassess their awareness about the H2020 crosscutting objective “Responsible Research and Innovation”.

This deliverable contains the first conclusions about the viability of electron magnetic chiral dichroism (EMCD) experiments, as the acquisition of atomic-scale EMCD is one of the main goals of the Project. In preparation for the actual EMCD measurement, a large comprehensive theoretical and experimental-test work was found out to be necessary. Such work focused on both the modified electron optics as well as on the interaction between probe electrons and sample and is described in this deliverable.

The purpose of this deliverable is to explain the actual installation of cryo-blades inside the Titan HOLO electron microscope and to illustrate difficulties and delays that characterised the installation. This report is strongly based on the report 5.1 and shows the comparison between the initial design and the actual realisation of the parts. The long term objective has been to introduce retractable cryo blades in TITAN HOLO microscope protecting a frozen biological specimen (cooled to liquid nitrogen temperature) to be safely studied with no contamination effect from the residual organic contaminants inside the electron microscope column and allowing also to implement Sorter phase element for the actual experiments since the microscope must be operated in non-standard conditions.

The purpose of this deliverable is to explain the unique design of cryo-blades with respect to the possibilities and restriction of the electron microscope dedicated to QSORT project for cryo-Em experiments as explained in WP5. In particular this deliverable describes the features that should have been considered to implement novel cryo-blades in a TITAN electron microscope.