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4,514 results on '"Tiemeier, Henning"'

5. Genetic variants for head size share genes and pathways with cancer

Author

Knol, Maria J, Poot, Raymond A, Evans, Tavia E, Satizabal, Claudia L, Mishra, Aniket, Sargurupremraj, Muralidharan, van der Auwera, Sandra, Duperron, Marie-Gabrielle, Jian, Xueqiu, Hostettler, Isabel C, van Dam-Nolen, Dianne HK, Lamballais, Sander, Pawlak, Mikolaj A, Lewis, Cora E, Carrion-Castillo, Amaia, van Erp, Theo GM, Reinbold, Céline S, Shin, Jean, Scholz, Markus, Håberg, Asta K, Kämpe, Anders, Li, Gloria HY, Avinun, Reut, Atkins, Joshua R, Hsu, Fang-Chi, Amod, Alyssa R, Lam, Max, Tsuchida, Ami, Teunissen, Mariël WA, Aygün, Nil, Patel, Yash, Liang, Dan, Beiser, Alexa S, Beyer, Frauke, Bis, Joshua C, Bos, Daniel, Bryan, R Nick, Bülow, Robin, Caspers, Svenja, Catheline, Gwenaëlle, Cecil, Charlotte AM, Dalvie, Shareefa, Dartigues, Jean-François, DeCarli, Charles, Enlund-Cerullo, Maria, Ford, Judith M, Franke, Barbara, Freedman, Barry I, Friedrich, Nele, Green, Melissa J, Haworth, Simon, Helmer, Catherine, Hoffmann, Per, Homuth, Georg, Ikram, M Kamran, Jack, Clifford R, Jahanshad, Neda, Jockwitz, Christiane, Kamatani, Yoichiro, Knodt, Annchen R, Li, Shuo, Lim, Keane, Longstreth, WT, Macciardi, Fabio, Consortium, The Cohorts for Heart and Aging Research in Genomic Epidemiology, Amouyel, Philippe, Arfanakis, Konstantinos, Aribisala, Benjamin S, Bastin, Mark E, Chauhan, Ganesh, Chen, Christopher, Cheng, Ching-Yu, de Jager, Philip L, Deary, Ian J, Fleischman, Debra A, Gottesman, Rebecca F, Gudnason, Vilmundur, Hilal, Saima, Hofer, Edith, Janowitz, Deborah, Jukema, J Wouter, Liewald, David CM, Lopez, Lorna M, Lopez, Oscar, Luciano, Michelle, Martinez, Oliver, Niessen, Wiro J, Nyquist, Paul, Rotter, Jerome I, Rundek, Tatjana, Sacco, Ralph L, Schmidt, Helena, Tiemeier, Henning, Trompet, Stella, van der Grond, Jeroen, Völzke, Henry, Wardlaw, Joanna M, Yanek, Lisa, Yang, Jingyun, and Consortium, The Enhancing NeuroImaging Genetics through Meta-Analysis

Subjects
Biomedical and Clinical Sciences, Biotechnology, Genetics, Cancer, Human Genome, Stem Cell Research, Neurosciences, 2.1 Biological and endogenous factors, 1.1 Normal biological development and functioning, Neurological, Humans, Genome-Wide Association Study, Head, Neoplasms, Female, Male, Polymorphism, Single Nucleotide, Genetic Variation, Organ Size, Signal Transduction, Adult, Genetic Predisposition to Disease, Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium, cancer, genetics, genome-wide association study, head circumference, head size, intracranial volume, meta-analysis, Biomedical and clinical sciences
Abstract

The size of the human head is highly heritable, but genetic drivers of its variation within the general population remain unmapped. We perform a genome-wide association study on head size (N = 80,890) and identify 67 genetic loci, of which 50 are novel. Neuroimaging studies show that 17 variants affect specific brain areas, but most have widespread effects. Gene set enrichment is observed for various cancers and the p53, Wnt, and ErbB signaling pathways. Genes harboring lead variants are enriched for macrocephaly syndrome genes (37-fold) and high-fidelity cancer genes (9-fold), which is not seen for human height variants. Head size variants are also near genes preferentially expressed in intermediate progenitor cells, neural cells linked to evolutionary brain expansion. Our results indicate that genes regulating early brain and cranial growth incline to neoplasia later in life, irrespective of height. This warrants investigation of clinical implications of the link between head size and cancer.

Published
2024

11. Running in the FAMILY: understanding and predicting the intergenerational transmission of mental illness

Author

van Houtum, Lisanne A. E. M., Baaré, William F. C., Beckmann, Christian F., Castro-Fornieles, Josefina, Cecil, Charlotte A. M., Dittrich, Juliane, Ebdrup, Bjørn H., Fegert, Jörg M., Havdahl, Alexandra, Hillegers, Manon H. J., Kalisch, Raffael, Kushner, Steven A., Mansuy, Isabelle M., Mežinska, Signe, Moreno, Carmen, Muetzel, Ryan L., Neumann, Alexander, Nordentoft, Merete, Pingault, Jean-Baptiste, Preisig, Martin, Raballo, Andrea, Saunders, John, Sprooten, Emma, Sugranyes, Gisela, Tiemeier, Henning, van Woerden, Geeske M., Vandeleur, Caroline L., and van Haren, Neeltje E. M.

Published
2024
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14. Maternal Postnatal Depressive Symptoms and Offspring Emotional and Behavioral Development at Age 7 Years in a U.K. Birth Cohort: The Role of Paternal Involvement

Author

Culpin, Iryna, Hammerton, Gemma, Stein, Alan, Bornstein, Marc H., Tiemeier, Henning, Cadman, Tim, Fredriksen, Eivor, Evans, Jonathan, Miller, Tina, Dermott, Esther, Heron, Jon, Sallis, Hannah M., and Pearson, Rebecca M.

Abstract

There is considerable variability in developmental outcomes of children whose mothers experience depression. Few longitudinal studies have examined contributions of paternal involvement in the association between maternal postnatal depression (PND) and offspring development. We examined pathways from maternal PND at 8 weeks (Edinburgh Postnatal Depression Scale; total score) to offspring emotional and behavioral development at 7 years (Strengths and Difficulties Questionnaire; total score) through behavioral, affective, and cognitive dimensions of paternal involvement in a U.K.-based birth cohort (Avon Longitudinal Study of Parents and Children; n = 3,434). Analyses were adjusted for baseline confounders and paternal PND (Edinburgh Postnatal Depression Scale; total score) as an intermediate confounder. Maternal PND was strongly associated with offspring development, but this association was not mediated by the combination of all indirect pathways through various dimensions of paternal involvement. Only father--child conflict emerged as a risk factor for adverse offspring development and as a mediator in the association between maternal PND and offspring development (albeit the effect size was small). If found causal, interventions that reduce father-child conflict may reduce the risk of adverse development in offspring of mothers with PND.

Published
2023
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17. Maternal Hyperglycemia in Pregnancy and Offspring Internalizing and Externalizing Behaviors

Author

Faleschini, Sabrina, Doyon, Myriam, Arguin, Mélina, Lepage, Jean-François, Tiemeier, Henning, Van Lieshout, Ryan J., and Perron, Patrice

Subjects
Pregnancy -- Analysis, Diabetes in pregnancy -- Development and progression, Pregnant women -- Health aspects, Health care industry
Abstract

Objective To examine the associations between exposure to gestational diabetes mellitus (GDM) and maternal glycemic markers during pregnancy and offspring behaviors at 3 and 5 years. We hypothesized that exposure to maternal hyperglycemia would be associated with more behavioral problems in offspring. Methods We included 548 mother-child pairs from the prospective pre-birth Gen3G cohort (Canada). Glycemic markers were measured during a 75 g oral glucose tolerance test (OGTT) in the second trimester of pregnancy. Based on OGTT, we classified 59 women (10.8%) as having GDM according to international diagnostic criteria. Mothers reported offspring behavior using the Strengths and Difficulties Questionnaire (SDQ) at 3 and 5 years, and the Child Behavior Checklist (CBCL) at 5 years. We used linear mixed models and multivariate regression to assess the associations between GDM or glycemic markers and children's behavior, adjusted for child sex and age, and maternal demographic factors, body mass index and family history of diabetes. Results Exposure to GDM was associated with higher SDQ externalizing scores at 3 and 5 years [B = 1.12, 95% CI (0.14, 2.10)] in fully adjusted linear mixed models. These results were supported by the CBCL at 5 years. Higher levels of maternal glucose at 1 h and 2 h during OGTT were associated with greater SDQ externalizing scores. Fasting glucose levels were not associated with child behavior scores. We did not observe associations between glycemic markers and internalizing behaviors. Conclusions Exposure to higher levels of maternal glycemia during pregnancy was associated with more externalizing behaviors in children at 3 and 5 years., Author(s): Sabrina Faleschini [sup.1] , Myriam Doyon [sup.2] , Mélina Arguin [sup.2] , Jean-François Lepage [sup.3] , Henning Tiemeier [sup.4] , Ryan J. Van Lieshout [sup.5] , Patrice Perron [sup.2] [...]

Published
2023
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23. Genome-wide Association Meta-analysis of Childhood and Adolescent Internalizing Symptoms

Author

Jami, Eshim S, Hammerschlag, Anke R, Ip, Hill F, Allegrini, Andrea G, Benyamin, Beben, Border, Richard, Diemer, Elizabeth W, Jiang, Chang, Karhunen, Ville, Lu, Yi, Lu, Qing, Mallard, Travis T, Mishra, Pashupati P, Nolte, Ilja M, Palviainen, Teemu, Peterson, Roseann E, Sallis, Hannah M, Shabalin, Andrey A, Tate, Ashley E, Thiering, Elisabeth, Vilor-Tejedor, Natàlia, Wang, Carol, Zhou, Ang, Adkins, Daniel E, Alemany, Silvia, Ask, Helga, Chen, Qi, Corley, Robin P, Ehli, Erik A, Evans, Luke M, Havdahl, Alexandra, Hagenbeek, Fiona A, Hakulinen, Christian, Henders, Anjali K, Hottenga, Jouke Jan, Korhonen, Tellervo, Mamun, Abdullah, Marrington, Shelby, Neumann, Alexander, Rimfeld, Kaili, Rivadeneira, Fernando, Silberg, Judy L, van Beijsterveldt, Catharina E, Vuoksimaa, Eero, Whipp, Alyce M, Tong, Xiaoran, Andreassen, Ole A, Boomsma, Dorret I, Brown, Sandra A, Burt, S Alexandra, Copeland, William, Dick, Danielle M, Harden, K Paige, Harris, Kathleen Mullan, Hartman, Catharina A, Heinrich, Joachim, Hewitt, John K, Hopfer, Christian, Hypponen, Elina, Jarvelin, Marjo-Riitta, Kaprio, Jaakko, Keltikangas-Järvinen, Liisa, Klump, Kelly L, Krauter, Kenneth, Kuja-Halkola, Ralf, Larsson, Henrik, Lehtimäki, Terho, Lichtenstein, Paul, Lundström, Sebastian, Maes, Hermine H, Magnus, Per, Munafò, Marcus R, Najman, Jake M, Njølstad, Pål R, Oldehinkel, Albertine J, Pennell, Craig E, Plomin, Robert, Reichborn-Kjennerud, Ted, Reynolds, Chandra, Rose, Richard J, Smolen, Andrew, Snieder, Harold, Stallings, Michael, Standl, Marie, Sunyer, Jordi, Tiemeier, Henning, Wadsworth, Sally J, Wall, Tamara L, Whitehouse, Andrew JO, Williams, Gail M, Ystrøm, Eivind, Nivard, Michel G, Bartels, Meike, and Middeldorp, Christel M

Subjects
Biological Psychology, Psychology, Serious Mental Illness, Brain Disorders, Pediatric, Human Genome, Genetics, Behavioral and Social Science, Depression, Mental Health, Mental Illness, 2.1 Biological and endogenous factors, 2.3 Psychological, social and economic factors, Mental health, Adolescent, Adult, Aggression, Anxiety, Attention Deficit Disorder with Hyperactivity, Autistic Disorder, Bipolar Disorder, Child, Child, Preschool, Genome-Wide Association Study, Humans, Loneliness, Polymorphism, Single Nucleotide, Schizophrenia, Sleep Initiation and Maintenance Disorders, depression, anxiety, repeated measures, genetic epidemiology, molecular genetics, Medical and Health Sciences, Psychology and Cognitive Sciences, Developmental & Child Psychology, Clinical sciences, Paediatrics, Applied and developmental psychology
Abstract

ObjectiveTo investigate the genetic architecture of internalizing symptoms in childhood and adolescence.MethodIn 22 cohorts, multiple univariate genome-wide association studies (GWASs) were performed using repeated assessments of internalizing symptoms, in a total of 64,561 children and adolescents between 3 and 18 years of age. Results were aggregated in meta-analyses that accounted for sample overlap, first using all available data, and then using subsets of measurements grouped by rater, age, and instrument.ResultsThe meta-analysis of overall internalizing symptoms (INToverall) detected no genome-wide significant hits and showed low single nucleotide polymorphism (SNP) heritability (1.66%, 95% CI = 0.84-2.48%, neffective = 132,260). Stratified analyses indicated rater-based heterogeneity in genetic effects, with self-reported internalizing symptoms showing the highest heritability (5.63%, 95% CI = 3.08%-8.18%). The contribution of additive genetic effects on internalizing symptoms appeared to be stable over age, with overlapping estimates of SNP heritability from early childhood to adolescence. Genetic correlations were observed with adult anxiety, depression, and the well-being spectrum (|rg| > 0.70), as well as with insomnia, loneliness, attention-deficit/hyperactivity disorder, autism, and childhood aggression (range |rg| = 0.42-0.60), whereas there were no robust associations with schizophrenia, bipolar disorder, obsessive-compulsive disorder, or anorexia nervosa.ConclusionGenetic correlations indicate that childhood and adolescent internalizing symptoms share substantial genetic vulnerabilities with adult internalizing disorders and other childhood psychiatric traits, which could partially explain both the persistence of internalizing symptoms over time and the high comorbidity among childhood psychiatric traits. Reducing phenotypic heterogeneity in childhood samples will be key in paving the way to future GWAS success.

Published
2022

27. Associations of prenatal maternal depressive symptoms with cord blood glucocorticoids and child hair cortisol levels in the project viva and the generation R cohorts: a prospective cohort study

Author

Cohen, Nathan J., Defina, Serena, Rifas-Shiman, Sheryl L., Faleschini, Sabrina, Kirby, Russell S., Chen, Henian, Wilson, Ronee, Fryer, Kimberly, Marroun, Hanan El, Cecil, Charlotte A.M., Hivert, Marie-France, Oken, Emily, Tiemeier, Henning, and Alman, Amy C.

Published
2023
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35. Meta-analysis of epigenome-wide associations between DNA methylation at birth and childhood cognitive skills

Author

Caramaschi, Doretta, Neumann, Alexander, Cardenas, Andres, Tindula, Gwen, Alemany, Silvia, Zillich, Lea, Pesce, Giancarlo, Lahti, Jari MT, Havdahl, Alexandra, Mulder, Rosa, Felix, Janine F, Tiemeier, Henning, Sirignano, Lea, Frank, Josef, Witt, Stephanie H, Rietschel, Marcella, Deuschle, Michael, Huen, Karen, Eskenazi, Brenda, Send, Tabea Sarah, Ferrer, Muriel, Gilles, Maria, de Agostini, Maria, Baïz, Nour, Rifas-Shiman, Sheryl L, Kvist, Tuomas, Czamara, Darina, Tuominen, Samuli T, Relton, Caroline L, Rai, Dheeraj, London, Stephanie J, Räikkönen, Katri, Holland, Nina, Annesi-Maesano, Isabella, Streit, Fabian, Hivert, Marie-France, Oken, Emily, Sunyer, Jordi, Cecil, Charlotte AM, and Sharp, Gemma

Subjects
Biological Psychology, Reproductive Medicine, Biomedical and Clinical Sciences, Psychology, Clinical Research, Pediatric, Human Genome, Behavioral and Social Science, Pediatric Research Initiative, Mental Health, Genetics, Aetiology, 2.1 Biological and endogenous factors, 2.2 Factors relating to the physical environment, Child, Cognition, CpG Islands, DNA Methylation, Epigenesis, Genetic, Epigenome, Female, Genome-Wide Association Study, Humans, Infant, Newborn, Pregnancy, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry, Clinical sciences, Biological psychology, Clinical and health psychology
Abstract

Cognitive skills are a strong predictor of a wide range of later life outcomes. Genetic and epigenetic associations across the genome explain some of the variation in general cognitive abilities in the general population and it is plausible that epigenetic associations might arise from prenatal environmental exposures and/or genetic variation early in life. We investigated the association between cord blood DNA methylation at birth and cognitive skills assessed in children from eight pregnancy cohorts within the Pregnancy And Childhood Epigenetics (PACE) Consortium across overall (total N = 2196), verbal (total N = 2206) and non-verbal cognitive scores (total N = 3300). The associations at single CpG sites were weak for all of the cognitive domains investigated. One region near DUSP22 on chromosome 6 was associated with non-verbal cognition in a model adjusted for maternal IQ. We conclude that there is little evidence to support the idea that variation in cord blood DNA methylation at single CpG sites is associated with cognitive skills and further studies are needed to confirm the association at DUSP22.

Published
2022

37. Genome-Wide Analyses of Vocabulary Size in Infancy and Toddlerhood: Associations With Attention-Deficit/Hyperactivity Disorder, Literacy, and Cognition-Related Traits

Author

Andreassen, Ole A., Bartels, Meike, Boomsma, Dorret, Dale, Philip S., Ehli, Erik, Fernandez-Orth, Dietmar, Guxens, Mònica, Hakulinen, Christian, Harris, Kathleen Mullan, Haworth, Simon, de Hoyos, Lucía, Jaddoe, Vincent, Keltikangas-Järvinen, Liisa, Lehtimäki, Terho, Middeldorp, Christel, Min, Josine L., Mishra, Pashupati P., Njølstad, Pål Rasmus, Sunyer, Jordi, Tate, Ashley E., Timpson, Nicholas, van der Laan, Camiel, Vrijheid, Martine, Vuoksimaa, Eero, Whipp, Alyce, Ystrom, Eivind, ACTION Consortium, Barwon Infant Study investigator group, Verhoef, Ellen, Allegrini, Andrea G., Jansen, Philip R., Lange, Katherine, Wang, Carol A., Morgan, Angela T., Ahluwalia, Tarunveer S., Symeonides, Christos, Eising, Else, Franken, Marie-Christine, Hypponen, Elina, Mansell, Toby, Olislagers, Mitchell, Omerovic, Emina, Rimfeld, Kaili, Schlag, Fenja, Selzam, Saskia, Shapland, Chin Yang, Tiemeier, Henning, Whitehouse, Andrew J.O., Saffery, Richard, Bønnelykke, Klaus, Reilly, Sheena, Pennell, Craig E., Wake, Melissa, Cecil, Charlotte A.M., Plomin, Robert, Fisher, Simon E., and St. Pourcain, Beate

Published
2024
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44. Loneliness, Not Social Support, Is Associated with Cognitive Decline and Dementia Across Two Longitudinal Population-Based Cohorts

Author

Freak-Poli, Rosanne, Wagemaker, Nina, Wang, Rui, Lysen, Thom S, Ikram, M Arfan, Vernooij, Meike W, Dintica, Christina S, Vernooij-Dassen, Myrra, Melis, Rene JF, Laukka, Erika J, Fratiglioni, Laura, Xu, Weili, and Tiemeier, Henning

Subjects
Acquired Cognitive Impairment, Aging, Alzheimer's Disease, Brain Disorders, Prevention, Behavioral and Social Science, Neurodegenerative, Mental Health, Depression, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Dementia, Clinical Research, Neurosciences, Mental health, Neurological, Good Health and Well Being, Aged, Aged, 80 and over, Cognitive Dysfunction, Female, Humans, Loneliness, Longitudinal Studies, Male, Mental Status and Dementia Tests, Middle Aged, Netherlands, Prevalence, Proportional Hazards Models, Risk Factors, Social Isolation, Sweden, cognition, dementia, depressive symptoms, interpersonal relations, loneliness, social support, Clinical Sciences, Cognitive Sciences, Neurology & Neurosurgery
Abstract

BackgroundPoor social health is likely associated with cognitive decline and risk of dementia; however, studies show inconsistent results. Additionally, few studies separate social health components or control for mental health.ObjectiveTo investigate whether loneliness and social support are independently associated with cognitive decline and risk of dementia, and whether depressive symptoms confound the association.MethodsWe included 4,514 participants from the population-based Rotterdam Study (RS; aged 71±7SD years) followed up to 14 years (median 10.8, interquartile range 7.4-11.6), and 2,112 participants from the Swedish National Study on Aging and Care in Kungsholmen (SNAC-K; aged 72±10SD years) followed up to 10 years (mean 5.9±1.6SD). At baseline, participants were free of major depression and scored on the Mini-Mental State Examination (MMSE) ≥26 for RS and ≥25 for SNAC-K. We investigated loneliness, perceived social support, and structural social support (specifically marital status and number of children). In both cohorts, dementia was diagnosed and cognitive function was repeatedly assessed with MMSE and a global cognitive factor (g-factor).ResultsLoneliness was prospectively associated with a decline in the MMSE in both cohorts. Consistently, persons who were lonely had an increased risk of developing dementia (RS: HR 1.34, 95%CI 1.08-1.67; SNAC-K: HR 2.16, 95%CI 1.12-4.17). Adjustment for depressive symptoms and exclusion of the first 5 years of follow-up did not alter results. Neither perceived or structural social support was associated with cognitive decline or dementia risk.ConclusionLoneliness, not social support, predicted cognitive decline and incident dementia independently of depressive symptoms.

Published
2022

45. Meta-analysis of epigenome-wide association studies in newborns and children show widespread sex differences in blood DNA methylation.

Author

Solomon, Olivia, Huen, Karen, Yousefi, Paul, Küpers, Leanne K, González, Juan R, Suderman, Matthew, Reese, Sarah E, Page, Christian M, Gruzieva, Olena, Rzehak, Peter, Gao, Lu, Bakulski, Kelly M, Novoloaca, Alexei, Allard, Catherine, Pappa, Irene, Llambrich, Maria, Vives, Marta, Jima, Dereje D, Kvist, Tuomas, Baccarelli, Andrea, White, Cory, Rezwan, Faisal I, Sharp, Gemma C, Tindula, Gwen, Bergström, Anna, Grote, Veit, Dou, John F, Isaevska, Elena, Magnus, Maria C, Corpeleijn, Eva, Perron, Patrice, Jaddoe, Vincent WV, Nohr, Ellen A, Maitre, Lea, Foraster, Maria, Hoyo, Cathrine, Håberg, Siri E, Lahti, Jari, DeMeo, Dawn L, Zhang, Hongmei, Karmaus, Wilfried, Kull, Inger, Koletzko, Berthold, Feinberg, Jason I, Gagliardi, Luigi, Bouchard, Luigi, Ramlau-Hansen, Cecilia Høst, Tiemeier, Henning, Santorelli, Gillian, Maguire, Rachel L, Czamara, Darina, Litonjua, Augusto A, Langhendries, Jean-Paul, Plusquin, Michelle, Lepeule, Johanna, Binder, Elisabeth B, Verduci, Elvira, Dwyer, Terence, Carracedo, Ángel, Ferre, Natalia, Eskenazi, Brenda, Kogevinas, Manolis, Nawrot, Tim S, Munthe-Kaas, Monica C, Herceg, Zdenko, Relton, Caroline, Melén, Erik, Gruszfeld, Dariusz, Breton, Carrie, Fallin, MD, Ghantous, Akram, Nystad, Wenche, Heude, Barbara, Snieder, Harold, Hivert, Marie-France, Felix, Janine F, Sørensen, Thorkild IA, Bustamante, Mariona, Murphy, Susan K, Raikkönen, Katri, Oken, Emily, Holloway, John W, Arshad, Syed Hasan, London, Stephanie J, and Holland, Nina

Subjects
Humans, DNA Methylation, Epigenesis, Genetic, Pregnancy, Sex Characteristics, Adolescent, Child, Infant, Newborn, Female, Male, Epigenomics, Epigenome, Children, Cord blood, DNA methylation, EWAS, Sex, Digestive Diseases, Human Genome, Genetics, Prevention, Pediatric, Aetiology, 2.1 Biological and endogenous factors, Good Health and Well Being, Toxicology
Abstract

BackgroundAmong children, sex-specific differences in disease prevalence, age of onset, and susceptibility have been observed in health conditions including asthma, immune response, metabolic health, some pediatric and adult cancers, and psychiatric disorders. Epigenetic modifications such as DNA methylation may play a role in the sexual differences observed in diseases and other physiological traits.MethodsWe performed a meta-analysis of the association of sex and cord blood DNA methylation at over 450,000 CpG sites in 8438 newborns from 17 cohorts participating in the Pregnancy And Childhood Epigenetics (PACE) Consortium. We also examined associations of child sex with DNA methylation in older children ages 5.5-10 years from 8 cohorts (n = 4268).ResultsIn newborn blood, sex was associated at Bonferroni level significance with differences in DNA methylation at 46,979 autosomal CpG sites (p

Published
2022

46. Early life exposure to greenness and executive function and behavior: An application of inverse probability weighting of marginal structural models.

Author

Jimenez, Marcia, Aris, Izzuddin, Rifas-Shiman, Sheryl, Young, Jessica, Tiemeier, Henning, Hivert, Marie-France, Oken, Emily, and James, Peter

Subjects
Childrens health, Executive function, Green space, Inverse probability weighting, Sensitive periods, Adolescent, Child, Child, Preschool, Environment, Executive Function, Humans, Infant, Newborn, Models, Structural, Probability
Abstract

Increasingly, studies suggest benefits of natural environments or greenness on childrens health. However, little is known about cumulative exposure or windows of susceptibility to greenness exposure. Using inverse probability weighting of marginal structural models (IPW/MSM), we estimated effects of greenness exposure from birth through adolescence on executive function and behavior. We analyzed data of 908 children from Project Viva enrolled at birth in 1999-2002 and followed up until early adolescence. In mid-childhood (median 7.7 years) and early adolescence (13.1 years), executive function and behavior were assessed using the Behavior Rating Inventory of Executive Function and the Strengths and Difficulties Questionnaire (SDQ). Greenness was measured at birth, early childhood, mid-childhood, and early adolescence, using the Normalized Difference Vegetation Index. We used inverse probability weighting of marginal structural models to estimate effects of interventions that ensure maximum greenness exposure versus minimum through all intervals; and that ensure maximum greenness only in early childhood (vs. minimum through all intervals). Results of the effects of maximum (vs. minimum) greenness at all timepoints did not suggest associations with mid-childhood outcomes. Estimates of maximum greenness only in early childhood (vs. minimum) suggested a beneficial association with mid-childhood SDQ (-3.21, 99 %CI: -6.71,0.29 mother-rated; -4.02, 99 %CI: -7.87,-0.17 teacher-rated). No associations were observed with early adolescent outcomes. Our results for persistent maximum greenness exposure on behavior, were not conclusive with confidence intervals containing the null. The results for maximum greenness only in early childhood may shed light on sensitive periods of greenness exposure for behavior regulation.

Published
2021

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