Search

Your search keyword '"Tibullo, D."' showing total 301 results
Start Over Author "Tibullo, D."
301 results on '"Tibullo, D."'

1. MacroH2A1.1 as a crossroad between epigenetics, inflammation and metabolism of mesenchymal stromal cells in myelodysplastic syndromes

Author

Giallongo, C., Dulcamare, I., Giallongo, S., Duminuco, A., Pieragostino, D., Cufaro, M. C., Amorini, A. M., Lazzarino, G., Romano, A., Parrinello, N., Di Rosa, M., Broggi, G., Caltabiano, R., Caraglia, M., Scrima, M., Pasquale, L. S., Tathode, M. S., Li Volti, G., Motterlini, R., Di Raimondo, F., Tibullo, D., and Palumbo, G. A.

Published
2023
Full Text
View/download PDF

3. P01 LACTATE TRAFFICKING INHIBITION RESTORES SENSITIVITY TO PROTEASOME INHIBITHORS AND ORCHESTRATES IMMUNOMICROENVIRONMENT IN MULTIPLE MYELOMA

Author

Giallongo, C., primary, Zuppelli, T., additional, Scandura, G., additional, La Spina, E., additional, Dulcamare, I., additional, Cambria, D., additional, Giallongo, S., additional, Romano, A., additional, Parrinello, N., additional, Del Fabro, V., additional, Aguennoz, M., additional, Li Volti, G., additional, Palumbo, G.A., additional, Di Raimondo, F., additional, and Tibullo, D., additional

Published
2023
Full Text
View/download PDF

4. MACROH2A1.1 SITS AT THE INTERPLAY BETWEEN EPIGENETICS AND INFLAMMATION OF MESENCHYMAL STROMAL CELLS IN MYELODYSPLASTIC SYNDROMES

Author

Giallongo, C., primary, Dulcamare, I., additional, Giallongo, S., additional, Duminuco, A., additional, Pieragostino, D., additional, Cufaro, M.C., additional, Amorini, A.M., additional, Lazzarino, G., additional, Romano, A., additional, Parrinello, N., additional, Marino, S., additional, Di Rosa, M., additional, Broggi, G., additional, Caltabiano, R., additional, Li Volti, G., additional, Motterlini, R., additional, Di Raimondo, F., additional, Tibullo, D., additional, and Palumbo, G., additional

Published
2023
Full Text
View/download PDF

5. P02 ARGININE DEPRIVATION INDUCES ACQUISITION OF A SENESCENT PHENOTYPE AND FAVORS GENOMIC INSTABILITY IN MULTIPLE MYELOMA PLASMACELLS

Author

Romano, A., primary, Scandura, G., additional, Giallongo, C., additional, La Spina, E., additional, Giallongo, S., additional, Longhitano, L., additional, Zuppelli, T., additional, Dulcamare, I., additional, Parrinello, N. L., additional, Polito, F., additional, Oteri, R., additional, Aguennouz, M., additional, Vicario, N., additional, Amorini, A. M., additional, Del Fabro, V., additional, Conticello, C., additional, Li Volti, G., additional, Palumbo, G. A., additional, Tibullo, D., additional, and Di Raimondo, F., additional

Published
2023
Full Text
View/download PDF

6. P59 ACTIVE TREATMENT AND LOW IGM ARE ASSOCIATED WITH INFERIOR SARS-COV-2 SPIKE ANTIBODY RESPONSE TO THREE DOSES OF COVID-19 RNA VACCINATION IN PATIENTS WITH MULTIPLE MYELOMA

Author

Duminuco, A., primary, Romano, A., additional, Leotta, D., additional, La Spina, E., additional, Cambria, D., additional, Bulla, A., additional, Del Fabro, V., additional, Tibullo, D., additional, Giallongo, C., additional, Palumbo, G.A., additional, Conticello, C., additional, and Di Raimondo, F., additional

Published
2023
Full Text
View/download PDF

10. P731: INTERPLAY BETWEEN INFLAMMATION AND EPIGENETICS IN TUMOR REPROGRAMMING OF MESENCHYMAL STROMAL CELLS (MSCS) IN MYELODYSPLASTIC SYNDROMES (MDS)

Author

Giallongo, C., primary, Dulcamare, I., additional, Tibullo, D., additional, Pieragostino, D., additional, Cufaro, M. C., additional, Amorini, M. A., additional, Lazzarino, G., additional, Romano, A., additional, Scandura, G., additional, Zuppelli, T., additional, Di Rosa, M., additional, Duminuco, A., additional, Broggi, G., additional, Caltabiano, R., additional, Floresti, R., additional, Motterlini, R., additional, Di Raimondo, F., additional, and Palumbo, G. A., additional

Published
2022
Full Text
View/download PDF

12. P988: LACTATE RESHAPES TUMOR MICROENVIRONMENT AND METABOLIC PROFILE IN MYELOFIBROSIS

Author

Giallongo, S., primary, Tibullo, D., additional, Spampinato, M., additional, Giallongo, C., additional, La Spina, E., additional, Longhitano, L., additional, Romano, A., additional, Dulcamare, I., additional, Barbato, A., additional, Scandura, G., additional, Amorini, A. M., additional, Lazzarino, G., additional, Zuppelli, T., additional, Caltabiano, R., additional, Li Volti, G., additional, Di Raimondo, F., additional, and Palumbo, G. A. M., additional

Published
2022
Full Text
View/download PDF

14. Hedgehog signaling pathways in multiple myeloma

Author

Dulcamare, I., primary, Giallongo, S., additional, Vicario, N., additional, Scandura, G., additional, Barbato, A., additional, La Spina, E., additional, Longhitano, L., additional, Cambria, D., additional, Tibullo, D., additional, Zuppelli, T., additional, Lo Furno, D., additional, Parenti, R., additional, Li Volti, G., additional, Palumbo, G.A., additional, Di Raimondo, F., additional, Romano, A., additional, and Giallongo, C., additional

Published
2022
Full Text
View/download PDF

16. Correction to: Analysis of common methodological flaws in the highest cited e-cigarette epidemiology research (Internal and Emergency Medicine, (2022), 17, 3, (887-909), 10.1007/s11739-022-02967-1)

Author

Hajat, C., Stein, E., Selya, A., Polosa, R., Alaimo, S., Anfuso, C. D., Barbagallo, I., Basile, F., Battiato, S., Benhamou, B., Bertino, G., Bianchi, A., Biondi, A. G., Brandi, M. L., Cacciola, E., Cacciola, R. R., Cacopardo, B. S., Calogero, A. E., Cambria, M. T., Campagna, D., Caraci, F., Cariola, A., Caruso, M., Caponnetto, P., Ciancio, A., Cibella, F., Mauro, M., Piazza, J., Stefano, A., Drago, F., Failla, S., Faraci, R., Ferlito, S., Ferrante, M., Ferro, A., Ferro, G. A., Frasca, F., Frittitta, L., Furneri, P. M., Gagliano, A., Gallo, G., Galvano, F., Grasso, G., Guarino, F., Gulino, A., Jannini, E. A., Vignera, S. L., Lazzarino, G., Ledda, C., Leonardi, R. M., Volti, G. L., Longo, A., Lupo, G., Malerba, M., Marletta, L., Nicolosi, G., Nocera, F., Conti, G. O., Palazzo, G., Parenti, R., Pedulla, E., Pulvirenti, A., Purrello, F., Rapisarda, F., Rapisarda, V., Rizzo, R., Ronsisvalle, S., Ronsisvalle, G., Ruggieri, M., Santagati, M., Satriano, C., Sciacca, L., Signorelli, M. S., Tatullo, M., Tibullo, D., Tomaselli, V., Volarevic, V., Zanoli, L., and Zappala, A.

Published
2022

17. Brain CHID1 Expression Correlates with NRGN and CALB1 in Healthy Subjects and AD Patients

Author

Castrogiovanni, P, Sanfilippo, C, Imbesi, R, Maugeri, G, Lo Furno, D, Tibullo, D, Castorina, A, Musumeci, G, Di Rosa, M, Castrogiovanni, P, Sanfilippo, C, Imbesi, R, Maugeri, G, Lo Furno, D, Tibullo, D, Castorina, A, Musumeci, G, and Di Rosa, M

Abstract

Alzheimer's disease is a progressive, devastating, and irreversible brain disorder that, day by day, destroys memory skills and social behavior. Despite this, the number of known genes suitable for discriminating between AD patients is insufficient. Among the genes potentially involved in the development of AD, there are the chitinase-like proteins (CLPs) CHI3L1, CHI3L2, and CHID1. The genes of the first two have been extensively investigated while, on the contrary, little information is available on CHID1. In this manuscript, we conducted transcriptome meta-analysis on an extensive sample of brains of healthy control subjects (n = 1849) (NDHC) and brains of AD patients (n = 1170) in order to demonstrate CHID1 involvement. Our analysis revealed an inverse correlation between the brain CHID1 expression levels and the age of NDHC subjects. Significant differences were highlighted comparing CHID1 expression of NDHC subjects and AD patients. Exclusive in AD patients, the CHID1 expression levels were correlated positively to calcium-binding adapter molecule 1 (IBA1) levels. Furthermore, both in NDHC and in AD patient's brains, the CHID1 expression levels were directly correlated with calbindin 1 (CALB1) and neurogranin (NRGN). According to brain regions, correlation differences were shown between the expression levels of CHID1 in prefrontal, frontal, occipital, cerebellum, temporal, and limbic system. Sex-related differences were only highlighted in NDHC. CHID1 represents a new chitinase potentially involved in the principal processes underlying Alzheimer's disease.

Published
2021

20. Mitochondrial functions, energy metabolism and protein glycosylation are interconnected processes mediating resistance to bortezomib in multiple myeloma cells

Author

Tibullo, D., Giallongo, C., Romano, A., Vicario, N., Barbato, A., Puglisi, F., Parenti, R., Amorini, A. M., Saab, M. W., Tavazzi, Barbara, Mangione, Renata, Brundo, M. V., Lazzarino, Giacomo, Palumbo, G. A., Volti, G. L., Di Raimondo, F., Lazzarino, G., Tavazzi B. (ORCID:0000-0001-8743-0895), Mangione R., Lazzarino G., Tibullo, D., Giallongo, C., Romano, A., Vicario, N., Barbato, A., Puglisi, F., Parenti, R., Amorini, A. M., Saab, M. W., Tavazzi, Barbara, Mangione, Renata, Brundo, M. V., Lazzarino, Giacomo, Palumbo, G. A., Volti, G. L., Di Raimondo, F., Lazzarino, G., Tavazzi B. (ORCID:0000-0001-8743-0895), Mangione R., and Lazzarino G.

Abstract

The proteasome inhibitor bortezomib (BTZ) has emerged as an effective drug for the treatment of multiple myeloma even though many patients relapse from BTZ therapy. The present study investigated the metabolic pathways underlying the acquisition of bortezomib resistance in multiple myeloma. We used two different clones of multiple myeloma cell lines exhibiting different sensitivities to BTZ (U266 and U266-R) and compared them in terms of metabolic profile, mitochondrial fitness and redox balance homeostasis capacity. Our results showed that the BTZ-resistant clone (U266-R) presented increased glycosylated UDP-derivatives when compared to BTZ-sensitive cells (U266), thus also suggesting higher activities of the hexosamine biosynthetic pathway (HBP), regulating not only protein O-and N-glycosylation but also mitochondrial functions. Notably, U266-R displayed increased mitochondrial biogenesis and mitochondrial dynamics associated with stronger antioxidant defenses. Furthermore, U266-R maintained a significantly higher concentration of substrates for protein glycosylation when compared to U266, particularly for UDP-GlcNac, thus further suggesting the importance of glycosylation in the BTZ pharmacological response. Moreover, BTZ-treated U266-R showed significantly higher ATP/ADP ratios and levels of ECP and also exhibited increased mitochondrial fitness and antioxidant response. In conclusions, our findings suggest that the HBP may play a major role in mitochondrial fitness, driving BTZ resistance in multiple myeloma and thus representing a possible target for new drug development for BTZ-resistant patients.

Published
2020

25. PS1362 TRYPTOPHAN DEPRIVATION DUE TO INCREASED IDO-1 TRIGGERS A METABOLIC ADAPTIVE RESPONSE AND DOWN-REGULATES CD38 IN MULTIPLE MYELOMA

Author

Romano, A., primary, Puglisi, F., additional, Parrinello, N.L., additional, Giallongo, C., additional, La Cava, P., additional, Todoerti, K., additional, Tibullo, D., additional, Camiolo, G., additional, Del Fabro, V., additional, Cambria, D., additional, Conticello, C., additional, Palumbo, G.A., additional, Cenci, S., additional, Neri, A., additional, and Di Raimondo, F., additional

Published
2019
Full Text
View/download PDF

26. PF658 THE NEUTROPHIL TO LYMPHOCYTE RATIO (NLR) IS A CHEAP SURROGATE OF EXPANSION OF MYELOID-DERIVED SUPPRESSOR CELLS IN MYELOFIBROSIS BEFORE AND AFTER TREATMENT WITH RUXOLITINIB: A SINGLE-CENTER EXPERIENCE

Author

Romano, A., primary, Parrinello, N.L., additional, Giallongo, C., additional, Puglisi, F., additional, Cambria, D., additional, Camiolo, G., additional, Tibullo, D., additional, Lambusta, E., additional, Raimondo, F. Di, additional, and Palumbo, G.A., additional

Published
2019
Full Text
View/download PDF

27. PF585 GENE-EXPRESSION PROFILE OF HIGH-DENSITY NEUTROPHILS REVEALS PROGRESSIVE DIFFERENCES IN MGUS AND MULTIPLE MYELOMA, ASSOCIATED WITH REDUCED PHAGOCYTOSIS AND INCREASED INFECTION SUSCEPTIBILITY

Author

Romano, A., primary, Parrinello, N.L., additional, Simeon, V., additional, Bellofiore, C., additional, Giallongo, C., additional, Puglisi, F., additional, Cava, P. La, additional, Camiolo, G., additional, Brundo, M.V., additional, Silvia, S., additional, Tibullo, D., additional, Palumbo, G.A., additional, Conticello, C., additional, Musto, P., additional, and Raimondo, F. Di, additional

Published
2019
Full Text
View/download PDF

29. Role of heme oxygenase-1 (HSP32) and HSP90 in glioblastoma

Author

Castracani C. C., Di Rosa M., Rappa F., Bono T., Furneri P. M., Avola R., Tibullo D., Li Volti G., Castracani C.C., Di Rosa M., Rappa F., Bono T., Furneri P.M., Avola R., Tibullo D., and Li Volti G.

Subjects
Heme oxygenase, Molecular chaperones, Heat shock protein, Hsp90, Glioblastoma, Cancer
Abstract

Glioblastoma (GBM) is the most common and malignant primary brain tumor in adults. The current treatment regimes for glioblastoma demonstrated a low efficiency and offer a poor prognosis. Advancements in conventional treatment strategies have only yielded modest improvements in overall survival. The heat shockproteins, heme oxygenase-1 (HO-1) and Hsp90, serve these pivotal roles in tumor cells and have been identified as effective targets for developing therapeutics. This topic review summarizes the current preclinical and clinical evidences and rationale to define the potential of HO-1 and Hsp90 in GBM progression and chemoresistance.

Published
2017

31. Biological properties of itraconazole-SLNs

Author

Fuochi, V., Carbone, C., Pignatello, R., Petronio Petronio, G., Avola, R., Puglisi, Giovanni, Tibullo, D., Giallongo, C., Puglisi, F., and Furneri, P. M.

Published
2018

36. Biological properties of Cakile maritima Scop. (Brassicaceae) extracts.

Author

FUOCHI, V., BARBAGALLO, I., DISTEFANO, A., PUGLISI, F., PALMERI, R., DI ROSA, M., GIALLONGO, C., LONGHITANO, L., FONTANA, P., SFERRAZZO, G., TIRALONGO, F., RACCUIA, S. A., RONSISVALLE, S., LI VOLTI, G., FURNERI, P. M., and TIBULLO, D.

Abstract

OBJECTIVE: Cakile maritima scop. (CKM) is a herbaceous plant (Brassicaceae) growing also in high salinity environment. It is an annual plant growing in clumps or mounds in the sand on beaches and bluffs. MATERIALS AND METHODS: Stems, seeds, leaves and flowers of CKM were used to obtain 70% of ethanol extracts. The phenolic content of the different extracts was evaluated by the Folin-Ciocalteu method. The separation of phytochemical compounds was based on ultra- performance liquid chromatography coupled to mass spectrometry. Radical scavenging activity was determined by 1,1-diphenyl-2-picrylhydrazyl assay. The qualitative assay for the inhibition of α-glucosidase was quantified spectrophotometrically and the anti-inflammatory activity was determined in the U937 cell line by using gene expression of pro-inflammatory cytokines. Cell viability assay was done in U937, MM1S, and U266 cells by using the 3-(4,5-Dimethyl- 2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide assay. The antimicrobial activity was investigated by MIC determination, "double- triple combinations assay", and growth inhibition curves analysis, using the extracts individually or in various combination. Statistical analysis was performed by the Student's t-test and ANOVA. RESULTS: All parts of the plant exhibited a high antioxidant capacity as measured by DPPH assay. Furthermore, all extracts reduced (about 10 folds) the expression of inflammatory cytokines in macrophage following LPS treatment. As regards the antibacterial activity, only the seeds extract was able to inhibit both Gram-negative and Gram-positive bacteria when tested alone, whereas dual combinations of different extracts (leaves, flowers, stems and seeds) caused bacterial inhibition exhibiting a synergic action. Finally, we showed that the extracts did not exhibit cytotoxic effects in normal cells and that, surprisingly, it exhibited an anti-proliferative effect (inhibition ≈80%) in multiple myeloma U266 cells. CONCLUSIONS: Our study suggests that CKM possesses antioxidant, anti-inflammatory, antibacterial, anti-proliferative activities and such pleiotropic effects may be exploited under various pathological conditions. [ABSTRACT FROM AUTHOR]

Published
2019

37. New Mediterranean Marine biodiversity records

Author

BILECENOGLU, M, ALFAYA, JEF, AZZURRO, E, BALDACCONI, R, BOYACI, YÖ, CIRCOSTA, V, COMPAGNO, LJV, COPPOLA, F, DEIDUN, A, DURGHAM, H, DURUCAN, F, ERGÜDEN, D, FERNÁNDEZ ÁLVAREZ, FÁ, GIGLIO, G, GÖKOĞLU, M, GÜRLEK, M, IKHTIYAR, S, KABASAKAL, H, KARACHLE, V, KATSANEVAKIS, S, KOUTSOGIANNOPOULOS, D, LANFRANCO, E, MICARELLI, P, ÖZVAROL,Y, PEÑA RIVAS, L, POURSANIDIS, D, SALIBA, J, SPERONE, E, TIBULLO, D, TIRALONGO, D, TRIPEPI, S, TURAN, C, VELLA, P, YOKEŞ, ZAVA, GIANGUZZA, Paola, BILECENOGLU, M, ALFAYA, JEF, AZZURRO, E, BALDACCONI, R, BOYACI, YÖ, CIRCOSTA, V, COMPAGNO, LJV, COPPOLA, F, DEIDUN, A, DURGHAM, H, DURUCAN, F, ERGÜDEN, D, FERNÁNDEZ-ÁLVAREZ, FÁ, GIANGUZZA, P, GIGLIO, G, GÖKOĞLU, M, GÜRLEK, M, IKHTIYAR, S, KABASAKAL, H, KARACHLE, V, KATSANEVAKIS, S, KOUTSOGIANNOPOULOS, D, LANFRANCO, E, MICARELLI, P, ÖZVAROL,Y, PEÑA-RIVAS, L, POURSANIDIS, D, SALIBA, J, SPERONE, E, TIBULLO, D, TIRALONGO, D, TRIPEPI, S, TURAN, C, VELLA, P, and YOKEŞ, ZAVA, MB

Subjects
Biodiversity, alien species, Settore BIO/07 - Ecologia
Abstract

Based on recent biodiversity studies carried out in different parts of the Mediterranean, the following 19 species are included as new records on the floral or faunal lists of the relevant ecosystems: the green algae Penicillus capitatus (Maltese waters); the nemertean Amphiporus allucens (Iberian Peninsula, Spain); the salp Salpa maxima (Syria); the opistobranchs Felimida britoi and Berghia coerulescens (Aegean Sea, Greece); the dusky shark Carcharhinus obscurus (central-west Mediterranean and Ionian Sea, Italy); Randall’s threadfin bream Nemipterus randalli, the broadbanded cardinalfish Apogon fasciatus and the goby Gobius kolombatovici (Aegean Sea, Turkey); the reticulated leatherjack Stephanolepis diaspros and the halacarid Agaue chevreuxi (Sea of Marmara, Turkey); the slimy liagora Ganonema farinosum, the yellowstripe barracuda Sphyraena chrysotaenia, the rayed pearl oyster Pinctada imbricata radiata and the Persian conch Conomurex persicus (south-eastern Kriti, Greece); the blenny Microlipophrys dalmatinus and the bastard grunt Pomadasys incisus (Ionian Sea, Italy); the brown shrimp Farfantepenaeus aztecus (north-eastern Levant, Turkey); the blue-crab Callinectes sapidus (Corfu, Ionian Sea, Greece). In addition, the findings of the following rare species improve currently available biogeographical knowledge: the oceanic pufferfish Lagocephalus lagocephalus (Malta); the yellow sea chub Kyphosus incisor (Almuñécar coast of Spain); the basking shark Cetorhinus maximus and the shortfin mako Isurus oxyrinchus (north-eastern Levant, Turkey).

Published
2013

47. Serum chitotriosidase in postmenopausal women with severe osteoporosis

Author

Musumeci, M, Palermo, A, D'Onofrio, L, Vadalà, G, Greto, V, Di Stasio, Enrico, Maddaloni, E, Di Rosa, M, Tibullo, D, Silvia, A, Napoli, N, Denaro, V, Manfrini, S., Di Stasio, Enrico (ORCID:0000-0003-1047-4261), Musumeci, M, Palermo, A, D'Onofrio, L, Vadalà, G, Greto, V, Di Stasio, Enrico, Maddaloni, E, Di Rosa, M, Tibullo, D, Silvia, A, Napoli, N, Denaro, V, Manfrini, S., and Di Stasio, Enrico (ORCID:0000-0003-1047-4261)

Abstract

Human chitotriosidase (Chit) increases during the osteoclast differentiation and their activity. We demonstrated that serum Chit was significantly higher in osteoporotic subjects than in healthy control ones and revealed a negative correlation between Chit and bone mineral density (BMD). This is the first study showing a correlation between Chit and severe postmenopausal osteoporosis.

Published
2016

Catalog

Books, media, physical & digital resources
See catalog results