Search

Radiation therapy (RT), a primary treatment for breast cancer (BC), may be associated with increased non-BC tumor risk. We aimed to examine second cutaneous melanoma (SCM) risk in BC patients who underwent RT and to assess their survival outcomes. Data from 520,977 BC patients diagnosed between 1973–2018 were collected from the Surveillance, Epidemiology, and End Results (SEER) database. Cumulative SCM incidence was estimated using the Fine–Gray competing risk model. Poisson regression analysis was conducted to calculate the standardized incidence ratio (SIR) and estimate the SCM relative risk in patients who underwent RT compared to those who did not. Overall survival (OS) and cancer-specific survival (CSS) were assessed using the Kaplan‒Meier method. Among the 520,977 BC patients, 243,676 (46.8%) underwent surgery and RT, while 277,301 (53.2%) only underwent surgery. Our results suggest that BC patients receiving RT had a higher SCM risk than those who did not (hazard ratio [HR] 1.40; 95% confidence interval [CI] 1.30-1.51; P < 0.001). SCM incidence was also higher in BC patients treated with RT than in the general US population (SIR 1.12; 95% CI 1.05-1.19; P < 0.05). However, SCM patients who received RT had a significantly higher 10-year survival rate than those who did not receive RT (14.90% vs 5.94%; P < 0.001). No significant difference was found in 10-year OS or 5-year CSS between SCM following RT and only primary cutaneous melanoma (OPCM), but SCM patients who did not receive RT had a significantly lower 10-year OS, with no significant difference in CSS. This study suggests an increased SCM likelihood in BC patients due to RT, although the overall risk is minimal.

[Objective] The village type identification was carried out scientifically to provide technical support and a decision-making reference for the formulation of the overall territorial space planning and the implementation of the rural revitalization strategy for Xingguo County, Jiangxi Province, in order to provide experience reference for the village type identification in the hills and mountains in Southern China. [Methods] Villages were taken as the research units. A village layout suitability evaluation index system and a rural revitalization potential evaluation index system were constructed. The village types in Xingguo County were identified by combining the AHP and CRITIC methods to determine the index weight. A coupling coordination model was constructed. [Results] ① The overall village layout suitability in Xingguo County was in the general level, and the suitability grades were mainly in the middle suitability level, with significant differences in spatial distribution, showing the spatial characteristics of "decreasing in a stepwise manner from the central part of the city to the surrounding areas" . ② The overall level of rural revitalization potential needs to be improved. The high-level areas were mainly located in the villages surrounding the urban areas and the resident villages of each township. ③ The coupling degree between the suitability of village layout and rural revitalization was high. The coordination degree needs to be improved from the average coupling coordination degree, with the largest number of villages at the primary coupling coordination degree. ④ The types of villages in Xingguo County were identified as suburban integration villages, clustered development villages, survival and upgrading villages, characteristic protection villages, and relocated and evacuated villages. Corresponding development strategies were proposed for different types of villages. [Conclusion] Village layout was closely related to local topography and social and economic development. The potential of rural revitalization was positively correlated with the suitability of rural layout. Therefore, different development strategies should be proposed for different village types.