Search

Your search keyword '"Tiano, Francesca"' showing total 6 results
Start Over Author "Tiano, Francesca"
6 results on '"Tiano, Francesca"'

3. Focal adhesion kinase and its epigenetic interactors as diagnostic and therapeutic hints for pediatric hepatoblastoma.

Author

Braghini, Maria Rita, De Stefanis, Cristiano, Tiano, Francesca, Castellano, Aurora, Cicolani, Nicolo', Pezzullo, Marco, Tocco, Valeria, Spada, Marco, Alaggio, Rita, Alisi, Anna, and Francalanci, Paola

Subjects
FOCAL adhesion kinase, ALPHA fetoproteins, EPIGENETICS, HEPATOBLASTOMA, GENE expression, HISTONE methylation
Abstract

Background: Hepatoblastoma (HB) is the most common pediatric hepatic malignancy. Despite the progress in HB treatment, investigating HB pathomechanisms to optimize stratification and therapies remains a focal point to improve the outcome for high-risk patients. Methods: Here, we pointed to explore the impact of these mechanisms in HB. An observational study was performed on liver samples from a cohort of 17 patients with a diagnosis of HB and two normal liver samples. The in vitro experiments were executed on the Huh6 human HB cell line treated with the FAK inhibitor TAE226. Results: Our results highlight a significant up-regulation of mRNA and protein expression of FAK in livers from HB with respect to normal livers. The increased protein expression of total and Tyr397 phosphorylated FAK (pTyr397FAK) was significantly correlated with the expression of some epigenetic regulators of histone H3 methylation and acetylation. Of note, the expression of pTyr397FAK, N-methyltransferase enzyme (EZH2) and tri-methylation of the H3K27 residue correlated with tumor size and alpha-fetoprotein (AFP) levels. Finally, TAE226 caused a significant reduction of pTyr397FAK, epigenetic regulators, AFP, EPCAM, OCT4, and SOX2, in association with anti-proliferative and proapoptotic effects on HB cells. Conclusion: Our results suggest a role of FAK in HB that requires further investigations mainly focused on the exploration of its effective diagnostic and therapeutic translatability. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

5. Hsa-miR223-3p circulating level is upregulated in Friedreich’s ataxia and inversely associated with HCLS1 associated protein X-1, HAX-1

Author

Quatrana, Andrea, primary, Morini, Elena, additional, Tiano, Francesca, additional, Vancheri, Chiara, additional, Panarello, Luca, additional, Romano, Silvia, additional, Marcotulli, Christian, additional, Casali, Carlo, additional, Mariotti, Caterina, additional, Mongelli, Alessia, additional, Fichera, Mario, additional, Rufini, Alessandra, additional, Condò, Ivano, additional, Novelli, Giuseppe, additional, Testi, Roberto, additional, Amati, Francesca, additional, and Malisan, Florence, additional

Published
2022
Full Text
View/download PDF

6. Frataxin deficiency in Friedreich’s ataxia is associated with reduced levels of HAX-1, a regulator of cardiomyocyte death and survival

Author

Tiano, Francesca, primary, Amati, Francesca, additional, Cherubini, Fabio, additional, Morini, Elena, additional, Vancheri, Chiara, additional, Maletta, Sara, additional, Fortuni, Silvia, additional, Serio, Dario, additional, Quatrana, Andrea, additional, Luffarelli, Riccardo, additional, Benini, Monica, additional, Alfedi, Giulia, additional, Panarello, Luca, additional, Rufini, Alessandra, additional, Toschi, Nicola, additional, Frontali, Marina, additional, Romano, Silvia, additional, Marcotulli, Christian, additional, Casali, Carlo, additional, Gioiosa, Silvia, additional, Mariotti, Caterina, additional, Mongelli, Alessia, additional, Fichera, Mario, additional, Condò, Ivano, additional, Novelli, Giuseppe, additional, Testi, Roberto, additional, and Malisan, Florence, additional

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results