9,975 results on '"Tian Feng"'
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2. FNDC5 prevents oxidative stress and neuronal apoptosis after traumatic brain injury through SIRT3-dependent regulation of mitochondrial quality control
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Yufeng Ge, Xun Wu, Yaning Cai, Qing Hu, Jin Wang, Shenghao Zhang, Baocheng Zhao, Wenxing Cui, Yang Wu, Qiang Wang, Tian Feng, Haixiao Liu, Yan Qu, and Shunnan Ge
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Cytology ,QH573-671 - Abstract
Abstract Mitochondrial dysfunction and oxidative stress are important mechanisms for secondary injury after traumatic brain injury (TBI), which result in progressive pathophysiological exacerbation. Although the Fibronectin type III domain-containing 5 (FNDC5) was reported to repress oxidative stress by retaining mitochondrial biogenesis and dynamics, its possible role in the secondary injury after TBI remain obscure. In present study, we observed that the level of serum irisin (the cleavage product of FNDC5) significantly correlated with the neurological outcomes of TBI patients. Knockout of FNDC5 increased the lesion volume and exacerbated apoptosis and neurological deficits after TBI in mice, while FNDC5 overexpression yielded a neuroprotective effect. Moreover, FNDC5 deficiency disrupted mitochondrial dynamics and function. Activation of Sirtuin 3 (SIRT3) alleviated FNDC5 deficiency-induced disruption of mitochondrial dynamics and bioenergetics. In neuron-specific SIRT3 knockout mice, FNDC5 failed to attenuate TBI-induced mitochondrial damage and brain injuries. Mechanically, FNDC5 deficiency led to reduced SIRT3 expression via enhanced ubiquitin degradation of transcription factor Nuclear factor erythroid 2-related factor 2 (NRF2), which contributed to the hyperacetylation and inactivation of key regulatory proteins of mitochondrial dynamics and function, including OPA1 and SOD2. Finally, engineered RVG29-conjugated nanoparticles were generated to selectively and efficiently deliver irisin to the brain of mice, which yielded a satisfactory curative effect against TBI. In conclusion, FNDC5/irisin exerts a protective role against acute brain injury by promoting SIRT3-dependent mitochondrial quality control and thus represents a potential target for neuroprotection after TBI.
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- 2024
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3. m1A inhibition fuels oncolytic virus-elicited antitumor immunity via downregulating MYC/PD-L1 signaling
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Shujin Li, Tian Feng, Yuantong Liu, Qichao Yang, An Song, Shuo Wang, Jun Xie, Junjie Zhang, Bifeng Yuan, and Zhijun Sun
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Dentistry ,RK1-715 - Abstract
Abstract N 1-methyladenosine (m1A) RNA methylation is critical for regulating mRNA translation; however, its role in the development, progression, and immunotherapy response of head and neck squamous cell carcinoma (HNSCC) remains largely unknown. Using Tgfbr1 and Pten conditional knockout (2cKO) mice, we found the neoplastic transformation of oral mucosa was accompanied by increased m1A modification levels. Analysis of m1A-associated genes identified TRMT61A as a key m1A writer linked to cancer progression and poor prognosis. Mechanistically, TRMT61A-mediated tRNA-m1A modification promotes MYC protein synthesis, upregulating programmed death-ligand 1 (PD-L1) expression. Moreover, m1A modification levels were also elevated in tumors treated with oncolytic herpes simplex virus (oHSV), contributing to reactive PD-L1 upregulation. Therapeutic m1A inhibition sustained oHSV-induced antitumor immunity and reduced tumor growth, representing a promising strategy to alleviate resistance. These findings indicate that m1A inhibition can prevent immune escape after oHSV therapy by reducing PD-L1 expression, providing a mutually reinforcing combination immunotherapy approach.
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- 2024
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4. Enhanced accuracy with Segmentation of Colorectal Polyp using NanoNetB, and Conditional Random Field Test-Time Augmentation
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Muhammad Sajjad Hussain, Umer Asgher, Sajid Nisar, Vladimir Socha, Arslan Shaukat, Jinhui Wang, Tian Feng, Rehan Zafar Paracha, and Muhammad Ali Khan
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colonoscopy ,conditional random field ,test-time augmentation ,lightweight deep learning models ,polyp segmentation ,colorectal cancer ,Mechanical engineering and machinery ,TJ1-1570 ,Electronic computers. Computer science ,QA75.5-76.95 - Abstract
Colonoscopy is a reliable diagnostic method to detect colorectal polyps early on and prevent colorectal cancer. The current examination techniques face a significant challenge of high missed rates, resulting in numerous undetected polyps and irregularities. Automated and real-time segmentation methods can help endoscopists to segment the shape and location of polyps from colonoscopy images in order to facilitate clinician’s timely diagnosis and interventions. Different parameters like shapes, small sizes of polyps, and their close resemblance to surrounding tissues make this task challenging. Furthermore, high-definition image quality and reliance on the operator make real-time and accurate endoscopic image segmentation more challenging. Deep learning models utilized for segmenting polyps, designed to capture diverse patterns, are becoming progressively complex. This complexity poses challenges for real-time medical operations. In clinical settings, utilizing automated methods requires the development of accurate, lightweight models with minimal latency, ensuring seamless integration with endoscopic hardware devices. To address these challenges, in this study a novel lightweight and more generalized Enhanced Nanonet model, an improved version of Nanonet using NanonetB for real-time and precise colonoscopy image segmentation, is proposed. The proposed model enhances the performance of Nanonet using Nanonet B on the overall prediction scheme by applying data augmentation, Conditional Random Field (CRF), and Test-Time Augmentation (TTA). Six publicly available datasets are utilized to perform thorough evaluations, assess generalizability, and validate the improvements: Kvasir-SEG, Endotect Challenge 2020, Kvasir-instrument, CVC-ClinicDB, CVC-ColonDB, and CVC-300. Through extensive experimentation, using the Kvasir-SEG dataset, our model achieves a mIoU score of 0.8188 and a Dice coefficient of 0.8060 with only 132,049 parameters and employing minimal computational resources. A thorough cross-dataset evaluation was performed to assess the generalization capability of the proposed Enhanced Nanonet model across various publicly available polyp datasets for potential real-world applications. The result of this study shows that using CRF (Conditional Random Fields) and TTA (Test-Time Augmentation) enhances performance within the same dataset and also across diverse datasets with a model size of just 132,049 parameters. Also, the proposed method indicates improved results in detecting smaller and sessile polyps (flats) that are significant contributors to the high miss rates.
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- 2024
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5. Corrigendum to 'Submicron emulsion of cinnamaldehyde ameliorates bleomycin-induced idiopathic pulmonary fibrosis via inhibition of inflammation, oxidative stress and epithelial-mesenchymal transition' [Biomed. Pharmacother. 102 (2018) 765–771]
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Li Yan, Fan Song, Hua Li, Yao Li, Jie Li, Qiao-Yan He, Di Zhang, Fang Wang, Meng Zhang, Hang Zhao, Tian Feng, Ying-Yong Zhao, and Si-Wang Wang
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Therapeutics. Pharmacology ,RM1-950 - Published
- 2024
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6. Evaluation of uncertainty in determination of two quaternary ammonium salt disinfectants in drinking water by high-performance liquid chromatography tandem mass spectrometry
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ZHANG Xuemei, KONG Xiangji, and TIAN Feng
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disinfectants ,quaternary ammonium compounds ,liquid chromatography tandem mass spectrometry method ,uncertainty ,Food processing and manufacture ,TP368-456 - Abstract
[Objective] To achieve good internal quality control of determination of decamethylammonium chloride and benzalkonium chloride residues in drinking water by high performance liquid chromatography tandem mass spectrometry, and to promote the improvement of detection methods. [Methods] A mathematical model and fishbone diagram were established to evaluate the introduced uncertainty components, and the combined standard uncertainty and expanded uncertainty were calculated. [Results] Under the inclusion factor k=2, and the decamethylammonium chloride and benzalkonium chloride residue in drinking water samples was 4.3 μg/L and 4.7 μg/L and their expanded uncertainty U was 0.52 μg/L and 0.48 μg/L, respectively. [Conclusion] The uncertainty in determining the two disinfectants with high performance liquid chromatography tandem mass spectrometry mainly comes from the preparation of the series standard solutions, determination repeatability, and instrument calibration, etc.
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- 2024
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7. Exploration of the Teaching Reforms of Modern Food Microbiology Course
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MAO Bing-yong, XIA Yu, ZHANG Qiu-xiang, LI Hai-tao, and TIAN Feng-wei
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modern food microbiology ,teaching reforms ,innovation ,practice ,closed-loop teaching ,Food processing and manufacture ,TP368-456 ,Nutrition. Foods and food supply ,TX341-641 - Abstract
Modern food microbiology is a core compulsory course of Food Science and Engineering and an important course in the teaching system of Food majors. We have conducted a research on teaching reform in response to the current problems of outdated teaching content, single teaching methods, and unscientific teaching assessment methods in curriculum teaching. We have taken multiple strategies, including introducing hot cases related to food microbiology in class to update the teaching content, encouraging students to conduct microbiological thematic discussions and presentations in class, adding feedbacks after the “homework submission-review scoring” to achieve a closed-loop teaching. After three rounds of teaching reform practice, the students’ feedback was good, and the teaching effects of modern food microbiology has been significantly improved.
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- 2024
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8. An investigation of inversion method to measure the radial velocity of Kuroshio from Sentinel-1 SAR data
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Benhua Tan, Lihua Wang, Dechen Ge, Zhen Fang, Weiwei Sun, and Tian Feng
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SAR ,Doppler shift ,non-geophysical ,ocean current ,Kuroshio ,Mathematical geography. Cartography ,GA1-1776 ,Environmental sciences ,GE1-350 - Abstract
ABSTRACTStudies on the retrieval of ocean surface current by Synthetic Aperture Radar (SAR) mainly concentrate on coastal regions with land coverage, allowing for continuous land to estimate non-geophysical Doppler shifts. As a strong western boundary in the Western Pacific, the Kuroshio flows through mostly islands or open sea, and lacks land coverage for range bias correction. We propose a non-geophysical Doppler shift correction algorithm suitable for Kuroshio observation. Three solutions matching different land coverage were adopted in the range direction, and the scalloping was removed by using average filtering in the azimuth direction. Comparison between SAR radial velocity and Global Surface Lagrangian Drifter (GLD) reveals that the correlation coefficient (R2) increase to 0.686, and root mean square error (RMSE) of 0.215 m/s after non-geophysical corrections, while the wind-wave bias corrections make R2 increase to 0.806 and RMSE decrease to 0.13 m/s. There is also a good consistency between SAR inversion and Regional Ocean Circulation Model (ROMS). Sensitivity analysis illustrates that ascending pass is more suitable for monitoring Kuroshio, and high incidence angles are less affected by ocean conditions and non-geophysical factors. The algorithm can be used in regions with discontinuous or absent land.
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- 2024
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9. Danshen-Shanzha formula for the treatment of atherosclerosis: ethnopharmacological relevance, preparation methods, chemical constituents, pharmacokinetic properties, and pharmacological effects
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Qiong Xu, Zhe Yu, Meng Zhang, Tian Feng, Fan Song, Haifeng Tang, Siwang Wang, and Hua Li
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danshen-shanzha formula ,herb pair ,radix salvia miltiorrhiza ,fructus crataegi ,atherosclerosis ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Danshen-Shanzha Formula (DSF) is a well-known herbal combination comprising Radix Salvia Miltiorrhiza (known as Danshen in Chinese) and Fructus Crataegi (known as Shanzha in Chinese), It has been documented to exhibit considerable benefits for promoting blood circulation and removing blood stasis, and was used extensively in the treatment of atherosclerotic cardiac and cerebral vascular diseases over decades. Despite several breakthroughs achieved in the basic research and clinical applications of DSF over the past decades, there is a lack of comprehensive reviews summarizing its features and research, which hinders further exploration and exploitation of this promising formula. This review aims to provide a comprehensive interpretation of DSF in terms of its ethnopharmacological relevance, preparation methods, chemical constituents, pharmacokinetic properties and pharmacological effects. The related information on Danshen, Shanzha, and DSF was obtained from internationally recognized online scientific databases, including Web of Science, PubMed, Google Scholar, China National Knowledge Infrastructure, Baidu Scholar, ScienceDirect, ACS Publications, Online Library, Wan Fang Database as well as Flora of China. Data were also gathered from documentations, printed works and classics, such as the Chinese Pharmacopoeia, Chinese herbal classics, etc. Three essential avenues for future studies were put forward as follows: a) Develop and unify the standard preparation method of DSF as to achieve optimized pharmacological properties. b) Elucidate the functional mechanisms as well as the rationality and rule for the compatibility art of DSF by focusing on the clinic syndromes together with the subsequent development of preclinic study system in vitro and in vivo with consistent pathological features, pharmacokinetical behaviour and biomarkers. c) Perform more extensive clinical studies towards the advancement of mechanism-based on evidence-based medicine on the safety application of DSF. This review will provide substantial data support and broader perspective for further research on the renowned formula.
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- 2024
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10. Discovery of novel covalent selective estrogen receptor degraders against endocrine-resistant breast cancer
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Yubo Wang, Jian Min, Xiangping Deng, Tian Feng, Hebing Hu, Xinyi Guo, Yan Cheng, Baohua Xie, Yu Yang, Chun-Chi Chen, Rey-Ting Guo, Chune Dong, and Hai-Bing Zhou
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Covalent strategy ,Estrogen receptor degraders ,Endocrine-resistant breast cancer ,X-ray crystallography ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Endocrine-resistance remains a major challenge in estrogen receptor α positive (ERα+) breast cancer (BC) treatment and constitutively active somatic mutations in ERα are a common mechanism. There is an urgent need to develop novel drugs with new mode of mechanism to fight endocrine-resistance. Given aberrant ERα activity, we herein report the identification of novel covalent selective estrogen receptor degraders (cSERDs) possessing the advantages of both covalent and degradation strategies. A highly potent cSERD 29c was identified with superior anti-proliferative activity than fulvestrant against a panel of ERα+ breast cancer cell lines including mutant ERα. Crystal structure of ERα‒29c complex alongside intact mass spectrometry revealed that 29c disrupted ERα protein homeostasis through covalent targeting C530 and strong hydrophobic interaction collied on H11, thus enforcing a unique antagonist conformation and driving the ERα degradation. These significant effects of the cSERD on ERα homeostasis, unlike typical ERα degraders that occur directly via long side chains perturbing the morphology of H12, demonstrating a distinct mechanism of action (MoA). In vivo, 29c showed potent antitumor activity in MCF-7 tumor xenograft models and low toxicity. This proof-of-principle study verifies that novel cSERDs offering new opportunities for the development of innovative therapies for endocrine-resistant BC.
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- 2023
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11. Metal-free electrochemical dihydroxylation of unactivated alkenes
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Min Liu, Tian Feng, Yanwei Wang, Guangsheng Kou, Qiuyan Wang, Qian Wang, and Youai Qiu
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Science - Abstract
Abstract Herein, a metal-free electrochemical dihydroxylation of unactivated alkenes is described. The transformation proceeds smoothly under mild conditions with a broad range of unactivated alkenes, providing valuable and versatile dihydroxylated products in moderate to good yields without the addition of costly transition metals and stoichiometric amounts of chemical oxidants. Moreover, this method can be applied to a range of natural products and pharmaceutical derivatives, further demonstrating its synthetic utility. Mechanistic studies have revealed that iodohydrin and epoxide intermediate are formed during the reaction process.
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- 2023
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12. Estimation of Coastal Wetland Vegetation Aboveground Biomass by Integrating UAV and Satellite Remote Sensing Data
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Xiaomeng Niu, Binjie Chen, Weiwei Sun, Tian Feng, Xiaodong Yang, Yangyi Liu, Weiwei Liu, and Bolin Fu
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aboveground biomass ,Sentinel-2 ,random forest ,multiple linear regression ,carbon sink ,satellite imagery ,Science - Abstract
Aboveground biomass (AGB) serves as a crucial indicator of the carbon sequestration capacity of coastal wetland ecosystems. Conducting extensive field surveys in coastal wetlands is both time-consuming and labor-intensive. Unmanned aerial vehicles (UAVs) and satellite remote sensing have been widely utilized to estimate regional AGB. However, the mixed pixel effects in satellite remote sensing hinder the precise estimation of AGB, while high-spatial resolution UAVs face challenges in estimating large-scale AGB. To fill this gap, this study proposed an integrated approach for estimating AGB using field sampling, a UAV, and Sentinel-2 satellite data. Firstly, based on multispectral data from the UAV, vegetation indices were computed and matched with field sampling data to develop the Field–UAV AGB estimation model, yielding AGB results at the UAV scale (1 m). Subsequently, these results were upscaled to the Sentinel-2 satellite scale (10 m). Vegetation indices from Sentinel-2 data were calculated and matched to establish the UAV–Satellite AGB model, enabling the estimation of AGB over large regional areas. Our findings revealed the AGB estimation model achieved an R2 value of 0.58 at the UAV scale and 0.74 at the satellite scale, significantly outperforming direct modeling from field data to satellite (R2 = −0.04). The AGB densities of the wetlands in Xieqian Bay, Meishan Bay, and Hangzhou Bay, Zhejiang Province, were 1440.27 g/m2, 1508.65 g/m2, and 1545.11 g/m2, respectively. The total AGB quantities were estimated to be 30,526.08 t, 34,219.97 t, and 296,382.91 t, respectively. This study underscores the potential of integrating UAV and satellite remote sensing for accurately assessing AGB in large coastal wetland regions, providing valuable support for the conservation and management of coastal wetland ecosystems.
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- 2024
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13. Research progress on the difference of atherosclerosis between different sexes
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WANG Ya‑wei and TIAN Feng
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atherosclerosis ,sex factors ,magnetic resonance imaging ,risk factors ,gastrointestinal microbiome ,inflammation ,review ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Cardiovascular and cerebrovascular diseases are the main causes of disability and death, and atherosclerosis is an important cause. The incidence of atherosclerosis in premenopausal women is significantly lower than that in men of the same age, while the incidence of atherosclerosis in postmenopausal women is significantly higher than that in men of the same age, which is closely related to estrogen levels. In this paper, sex differences in atherosclerosis were reviewed from the aspects of imaging examination, risk factors, intestinal microbiome and vascular inflammatory effects on atherosclerosis, to provide evidence for precision medical treatment of atherosclerosis.
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- 2023
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14. Estimation of Soil Characteristic Parameters for Electric Mountain Tractor Based on Gauss–Newton Iteration Method
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Zhiqiang Xi, Tian Feng, Zhijun Liu, Huaijun Xu, Jingyang Zheng, and Liyou Xu
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Gauss–Newton iteration ,soil characteristic parameters ,electric mountain tractor ,ground passability ,Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 ,Transportation engineering ,TA1001-1280 - Abstract
Future field work tasks will require mountain tractors to pass through rough terrain with limited human supervision. The wheel–soil interaction plays a critical role in rugged terrain mobility. In this paper, an algorithm for the estimation of soil characteristic parameters based on the Simpson numerical integration method and Gauss–Newton iteration method is presented. These parameters can be used for passability prediction or in a traction control algorithm to improve tractor mobility and to plan safe operation paths for autonomous navigation systems. To verify the effectiveness of the solving algorithm, different initial values and soils were selected for simulation calculations of soil characteristic parameters such as internal friction angle, settlement index, and the joint parameter of soil cohesion modulus and friction modulus. The results show that the error was kept within 2%, and the calculation time did not exceed 0.84 s, demonstrating high robustness and real-time performance. To test the applicability of the algorithm model, further research was conducted using different wheel parameters of electric mountain tractors under wet clay conditions. The results show that these parameters also have high accuracy and stability with only a few iterations. Thus, the estimation algorithm can meet the requirements of quickly and accurately identifying soil characteristic parameters during tractor operation. A criterion for the passability of wheeled tractors through unknown terrain is proposed, utilizing identified soil parameters.
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- 2024
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15. Impact of urban spatial structure elements on carbon emissions efficiency in growing megacities: the case of Chengdu
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Tian Feng and Bo Zhou
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Medicine ,Science - Abstract
Abstract Quantitative research on the impact weight and impact of regional heterogeneity of urban spatial structure elements on carbon emissions efficiency can provide a scientific basis and practical guidance for low-carbon and sustainable urban development. This study uses the megacity of Chengdu as an example to measure and analyze the spatial carbon emission efficiency and multidimensional spatial structure elements by building a high-resolution grid and identifying the main spatial structure elements that affect urban carbon emissions and their impact weights via the Ordinary Least Squares regression (OLS) and Geographically Weighted Regression (GWR). The spatial heterogeneity of the impact of each element is also explored. The results show that the overall carbon emission efficiency of Chengdu is high in the center and low on the sides, which is related to urban density, functional mix, land use, and traffic structure. However, the influence of each spatial structure element is different in the developed central areas, developing areas of the plain, mountainous developing areas, underdeveloped areas of the plain, and mountainous underdeveloped areas. Thus, it is appropriate to form differentiated urban planning strategies based on the characteristics of the development of each zone. The findings provide inspiration and a scientific basis for formulating policies and practice to the future low-carbon development of Chengdu, while provide a reference for other growing megacities.
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- 2023
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16. Study on seepage model of Multiple Horizontal wells with complex fracture networks in tight Reservoir Based on boundary element method
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Zongxiao Ren, Zhan Qu, Shuaihu Jia, Guiyi Zhang, Chaobo Fan, Tian Feng, and Zhongxing Ren
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Boundary element method ,Irregular reservoir boundary ,Complex fracture network ,Multiple horizontal wells ,Tight reservoir ,Gas industry ,TP751-762 - Abstract
Horizontal well and volume fracturing technology are the key technologies to develop unconventional reservoirs. Tight reservoir is belonging to multi-scale seepage mediaafter fracturing, and theflow of fluid in it is extremely complicated. In this paper, based on the boundary element method (BEM), the seepage model of horizontal wells with complex fracture networks in irregular boundary reservoir is established for the first time. The model takes into account the influence of irregular reservoir boundary, dual media, complex fracture network and interference of multiple wells on horizontal well seepage. Using this model, the sensitivity analysis of wellbore storage coefficient, skin factor, fracture permeability and interporosity transfer coefficient is carried out. The model expands the application scope of BEM in the field of seepage simulation of unconventional oil and gas reservoirs and provides theoretical guidance for the development of tight oil reservoirs.
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- 2023
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17. Visual search strategies of performance monitoring used in action anticipation of basketball players
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Yawei Li, Tian Feng, Fuchun Zhang, Umer Asgher, Bingbing Yan, and Tianyu Peng
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action anticipation ,basketball player ,eye‐movement ,performance monitoring ,visual search ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Abstract Introduction Numerous studies have found that expert players anticipate better than novices. If more accurate prediction represents performance monitoring of experts, what are the advantages of elite basketball players in identifying and processing available cues? There is still a lack of sufficient evidence. This study examined the visual search in basketball players and explored the performance monitoring of action anticipation, adopting an expert–novice paradigm and eye‐movement technology. Methods Forty basketball players were recruited in this study: 20 in the expert group and 20 in the novice group. Participants were asked to predict the outcome of videotaped basketball throws and their accuracy and eye‐movement characteristics were record. Results The accuracy of the expert was significantly higher than that of the novice. The experts were able to instantly search and identify important cues in anticipation, and the gaze area of the experts was concentrated on the area of interest of the body. Additionally, the expert group showed long, repetitive, and rapid visual search of vital information, and improved their performance of the task. Conclusion The experts could monitor the performance of prediction by grabbing vital shooting information (such as the body of a player). The results suggest the athletes and coaches that if they want to improve the ability of prediction, it may be useful to shift their focus of attention from ball trajectory to body action.
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- 2023
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18. Immune-Boosting Effect of the COVID-19 Vaccine: Real-World Bidirectional Cohort Study
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Ming Liu, Tianshuo Zhao, Qiuyue Mu, Ruizhi Zhang, Chunting Liu, Fei Xu, Luxiang Liang, Linglu Zhao, Suye Zhao, Xianming Cai, Mingting Wang, Ninghua Huang, Tian Feng, Shiguang Lei, Guanghong Yang, and Fuqiang Cui
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Public aspects of medicine ,RA1-1270 - Abstract
BackgroundAs the SARS-CoV-2 attenuates and antibodies from the COVID-19 vaccine decline, long-term attention should be paid to the durability of primary booster administration and the preventive effect of the second or multiple booster doses of the COVID-19 vaccine. ObjectiveThis study aimed to explore the durability of primary booster administration and the preventive effect of second or multiple booster doses of the COVID-19 vaccine. MethodsWe established a bidirectional cohort in Guizhou Province, China. Eligible participants who had received the primary booster dose were enrolled for blood sample collection and administration of the second booster dose. A retrospective cohort for the time of administration was constructed to evaluate antibody attenuation 6-12 months after the primary booster dose, while a prospective cohort on the vaccine effect of the second booster dose was constructed for 4 months after the second administration. ResultsBetween September 21, 2022, and January 30, 2023, a total of 327 participants were included in the final statistical analysis plan. The retrospective cohort revealed that approximately 6-12 months after receiving the primary booster, immunoglobulin G (IgG) slowly declined with time, while immunoglobulin A (IgA) remained almost constant. The prospective cohort showed that 28 days after receiving the second booster, the antibody levels were significantly improved. Higher levels of IgG and IgA were associated with better protection against COVID-19 infection for vaccine recipients. Regarding the protection of antibody levels against post–COVID-19 symptoms, the increase of the IgG had a protective effect on brain fog and sleep quality, while IgA had a protective effect on shortness of breath, brain fog, impaired coordination, and physical pain. ConclusionsThe IgG and IgA produced by the second booster dose of COVID-19 vaccines can protect against SARS-CoV-2 infection and may alleviate some post–COVID-19 symptoms. Further data and studies on secondary booster administration are required to confirm these conclusions.
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- 2023
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19. Routes to reduction of phosphate by high-energy events
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Luca Bindi, Tian Feng, and Matthew A. Pasek
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Geology ,QE1-996.5 ,Environmental sciences ,GE1-350 - Abstract
Phosphorus with an oxidation state intermediate between phosphate and phosphide is identified in a calcium phosphite material within a lightning-produced fulgurite from New Port Richey, Florida, USA using nanotomography and micro-analytical observations.
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- 2023
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20. Graphene Channel Electron-Multiplying Charge-Coupled Pixel
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Munir Ali, Afshan Khaliq, Muhammad Abid Anwar, Jianhang Lv, Muhammad Malik, Tian Feng, Srikrishna Chanakya Bodepudi, Hongwei Guo, Khurram Shehzad, Zongwen Li, Yunfan Dong, Wei Liu, Huan Hu, Yuda Zhao, Bin Yu, and Yang Xu
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Displacement current ,field-effect coupling ,graphene channel current ,graphene charge-coupled device (GCCD) pixel ,multiplication factor ,pre-avalanche condition ,Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 - Abstract
This work presents an in-situ readout of the transient photoresponse of a graphene-oxide-semiconductor heterostructure by utilizing graphene’s field-effect coupling with the silicon photogate. The reported device which acts as a graphene charge-coupled device (GCCD) pixel is set into pre-avalanche condition by dynamic sinusoidal biasing and then exposed with pulsed illumination. The initial photo-ionized charge packet experiences pre-integration carrier multiplication, boosting the signal-to-noise ratio (SNR) before interacting with the surface traps and defects. The maximum multiplication factor of $\mathrm {\sim }8.5$ and responsivity of $\mathrm {350 A/W}$ are achieved. Arrhenius plots show the viability of operating the device at room temperature as thermal charge contribution is negligible. Moreover, a detailed discussion on reduced power consumption for such a sinusoidal charge-coupled device (CCD) drive concept is also incorporated. The presented technique paves the way for futuristic sinusoidally-driven graphene-silicon-based electron-multiplying CCDs with low-power surveillance and adaptive optics applications.
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- 2023
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21. Human Cord Blood–Endothelial Progenitor Cells Alleviate Intimal Hyperplasia of Arterial Damage in a Rat Stroke Model
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Hongming Sun, Ryuta Morihara, Tian Feng, Zhihong Bian, Haibo Yu, Xiao Hu, Xinran Hu, Yuting Bian, Ryo Sasaki, Yusuke Fukui, Mami Takemoto, Taijun Yunoki, Yumiko Nakano, Koji Abe, and Toru Yamashita
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Medicine - Abstract
Human cord blood–endothelial progenitor cells (hCB-EPCs) isolated from the human umbilical cord can be used to repair damaged arteries. In this study, we used an animal model with pathological changes that mimics artery wall damage caused by stent retrievers in humans. We injected hCB-EPCs to investigate their effect on endothelial hyperplasia and dysfunction during intimal repair. Four groups were established based on the length of reperfusion (3 and 28 days), as well as the presence or absence of hCB-EPC therapy. Damage to the internal carotid artery was evaluated by hematoxylin-eosin and immunohistochemical staining. Stroke volume was not significantly different between non-EPC and EPC groups although EPC treatment alleviated intimal hyperplasia 28 days after intimal damage. Vascular endothelial growth factor (VEGF) and eNOS expression were significantly higher in the EPC-treated group than in the non-EPC group 3 days after intimal damage. In addition, MMP9 and 4HNE expression in the EPC-treated group was significantly lower than in the non-EPC group. Ultimately, this study found that venous transplantation of hCB-EPCs could inhibit neointimal hyperplasia, alleviate endothelial dysfunction, suppress intimal inflammation, and reduce oxidative stress during healing of intimal damage.
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- 2023
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22. Genomic characterization of Pantoea anthophila strain UI705 causing urinary tract infections in China
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Yingmiao Zhang, Yue Fan, Yu Zhan, Hao Wang, Xun Li, Hui Wang, Tian Feng, Lifeng Shi, Jing Wang, and Zhongxin Lu
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Pantoea anthophila ,urinary tract infection ,16S rRNA ,MALDI-TOF MS ,whole genome sequencing (WGS) ,Microbiology ,QR1-502 - Abstract
IntroductionPantoea anthophila (P. anthophila) is a Gram-negative bacterium initially isolated from Impatiens balsamina in India. P. anthophila has been characterized with low pathogenicity, and no human infections caused by this organism have been reported yet. We report the first case of urinary tract infection caused by P. anthophila in a 73-year-old man after bladder cancer surgery.MethodsThe bacterial isolate gained from urine was named UI705 and identified as P. anthophila by MALDI-TOF mass spectrometry. The genome sequencing and analysis were performed to further characterize the pathogenesis of the clinical isolate.Result and discussionTo the best of our knowledge, this is the first report of human infection caused by P. anthophila in China. The draft genome sequence of P. anthophila UI705 provides a fundamental resource for subsequent investigation of its virulence factors, antibiotic resistance, host–pathogen interactions, and comparative genomics of genus Pantoea.
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- 2023
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23. Prebiotic Syntheses of Organophosphorus Compounds from Reduced Source of Phosphorus in Non-Aqueous Solvents
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Maheen Gull, Tian Feng, Benjamin Smith, Laurent Calcul, and Matthew A. Pasek
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organophosphorus compounds ,origin of life ,non-aqueous solvents ,condensation ,phosphorylation ,biological esters ,Science - Abstract
Reduced-oxidation-state phosphorus (reduced P, hereafter) compounds were likely available on the early Earth via meteorites or through various geologic processes. Due to their reactivity and high solubility, these compounds could have played a significant role in the origin of various organophosphorus compounds of biochemical significance. In the present work, we study the reactions between reduced P compounds and their oxidation products, with the three nucleosides (uridine, adenosine, and cytidine), with organic alcohols (glycerol and ethanolamine), and with the tertiary ammonium organic compound, choline chloride. These reactions were studied in the non-aqueous solvent formamide and in a semi-aqueous solvent comprised of urea: ammonium formate: water (UAFW, hereafter) at temperatures of 55–68 °C. The inorganic P compounds generated through Fenton chemistry readily dissolve in the non-aqueous and semi-aqueous solvents and react with organics to form organophosphites and organophosphates, including those which are identified as phosphate diesters. This dual approach (1) use of non-aqueous and semi-aqueous solvents and (2) use of a reactive inorganic P source to promote phosphorylation and phosphonylation reactions of organics readily promoted anhydrous chemistry and condensation reactions, without requiring any additive, catalyst, or other promoting agent under mild heating conditions. We also present a comparative study of the release of P from various prebiotically relevant phosphate minerals and phosphite salts (e.g., vivianite, apatite, and phosphites of iron and calcium) into formamide and UAFW. These results have direct implications for the origin of biological P compounds from non-aqueous solvents of prebiotic provenance.
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- 2023
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24. Analysis of microstructural deformation in polytetrafluoroethylene under heating or stretching conditions by synchrotron X-ray scattering
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SHA Feixiang, CHENG Guojun, TIAN Feng, and TANG Zhongfeng
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polytetrafluoroethylene ,microstructure ,synchrotron radiation ,small-angle x-ray scattering (saxs) ,ultra small-angle x-ray scattering (usaxs) ,Nuclear and particle physics. Atomic energy. Radioactivity ,QC770-798 ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
The analysis of microstructure deformation in polytetrafluoroethylene (PTFE) under heating or stretching conditions is essential to determine the failure mechanism. This study employed the synchrotron X-ray scattering technique to study microstructural deformation in PTFE under heating (25~300 °C), different strains at room temperature, and constant stress at variable temperatures (25~175 °C). The results indicate that the scattering the scattering intensity of PTFE increases with an increase in the temperature, and the imperfect crystals gradually melt. When PTFE was stretched under relatively lower strains at room temperature, its molecular chains tilted and lamellar crystals slid and rotated along the stretching direction. Moreover, when PTFE was stretched at constant stress and varying temperatures, its imperfect crystals gradually melted with an increase in the temperature and lamellar crystals were fractured by stress; the crystals were further fractured owing to the α-transition temperature caused by the movement of molecular chains in the amorphous regions.
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- 2022
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25. Facile and general electrochemical deuteration of unactivated alkyl halides
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Pengfei Li, Chengcheng Guo, Siyi Wang, Dengke Ma, Tian Feng, Yanwei Wang, and Youai Qiu
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Science - Abstract
Deuterium-labelled compounds are useful for mechanistic studies and pharmaceutical science, but syntheses are not trivial. Here, the authors report deuteration of unactivated alkyl (pseudo)halides driven by electrochemical force, using deuterium oxide as the source of the isotope.
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- 2022
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26. RESEARCH ON THERMAL FATIGUE LIFE OF SOLDER JOINTS FOR AIRBORNE ELECTRONIC EQUIPMENT
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CU QiangYi, LIU ZhiHu, TIAN Feng, ZHANG FengHua, ZHAO Gang, and WU Bo
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Airborne electronic equipment ,Solder joints ,Thermal fatigue life ,Simulation ,Accelerated test ,Mechanical engineering and machinery ,TJ1-1570 ,Materials of engineering and construction. Mechanics of materials ,TA401-492 - Abstract
Aiming at the problem of thermal fatigue of solder joints for airborne electronic equipment, the evaluation method of thermal fatigue life of solder joints suitable for engineering application was studied, considered that the empirical equation based on strain energy was suitable for multiple components on PCBA. The accelerated test method of thermal fatigue life of solder joints was discussed, the accelerated test case proved that the test was feasible, and the simulation was credible. The results indicated that the simulation and accelerated test method of thermal fatigue life of solder joints were suitable for engineering application.
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- 2022
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27. Development of the System of Training Surgical Skills Based on Hierarchical Progressive Training for Clinical Postdoctoral Trainees
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GUO Chao, LIU Lei, ZHAI Jiliang, PAN Bo, LIANG Naixin, TIAN Feng, YI Jie, LIAO Quan, ZHU Huijuan, and WENG Xisheng
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clinical postdoctoral trainee ,elite medical education ,surgical skills ,hierarchical progressive training ,Medicine - Abstract
Objective Postdoctoral program in clinical medicine is a new approach to China's exploration of medical elite training. Since 2016, the Department of Surgery of Peking Union Medical College Hospital has explored and gradually established an advanced training system in order to cultivate clinical post-doctoral skills. The purpose of this research is to review and analyze the construction process and training effects of the advanced skill-raining system, and discuss the advantages of the training system and the direction of further improvement. Methods Postdoctoral students of surgical clinical medicine from 2016 to 2019 were evaluated and analyzed on surgical skills, results of the establishment of the system, and the output of scientific research. Results With the currently established preliminary system of progressively training surgical skills, three generations of 26 clinical postdoctoral trainees of surgery have been successfully trained. The surgical postdoctoral students trained by this system have significantly higher annual assessment results of surgical skills than training residents of the same year. In addition, during the establishment of this system, 19 teaching-related reform projects have been established, and 14 papers related to this system have been published. Conclusions The advanced training system of surgical skills has shown obvious advantages in the training process of surgical postdoctoral doctors. The construction and perfection of the system still needs to be further improved in combination with the actual needs of postdoctoral surgeons in surgery and the goal of standardized training for residents.
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- 2022
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28. EdgePhase: A Deep Learning Model for Multi‐Station Seismic Phase Picking
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Tian Feng, Saeed Mohanna, and Lingsen Meng
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deep learning ,seismic phase picking ,graph neural network ,edge convolution ,Samos earthquake ,EdgePhase ,Geophysics. Cosmic physics ,QC801-809 ,Geology ,QE1-996.5 - Abstract
Abstract In this study, we build a multi‐station phase‐picking model named EdgePhase by integrating an Edge Convolutional module with a state‐of‐the‐art single‐station phase‐picking model, EQTransformer. The Edge Convolutional module, a variant of Graph Neural Network, exchanges information relevant to seismic phases between neighboring stations. In EdgePhase, seismograms are first encoded into the latent representations, then converted into enhanced representations by the Edge Convolutional module, and finally decoded into the P‐ and S‐phase probabilities. Compared to the standard EQTransformer, EdgePhase increases the precision (fraction of phase identifications that are real) and recall (fraction of phase arrivals that are identified) rate by 5% on our training and test data sets of Southern California earthquakes. To evaluate its performance in regions of different tectonic settings, we applied EdgePhase to detect the early aftershocks following the 2020 M7.0 Samos, Greece earthquake. Compared to a local earthquake catalog, EdgePhase produced 190% additional detections with an event distribution more conformative to a planar fault interface, suggesting higher fidelity in event locations. This case study indicates that EdgePhase provides a strong regional generalization capability in real‐world applications.
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- 2022
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29. Cell sheet formation enhances the therapeutic effects of human umbilical cord mesenchymal stem cells on myocardial infarction as a bioactive material
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Rui Guo, M.D., Ph.D., Feng Wan, Masatoshi Morimatsu, Qing Xu, Tian Feng, Hang Yang, Yichen Gong, Shuhong Ma, Yun Chang, Siyao Zhang, Youxu Jiang, Heqing Wang, Dehua Chang, Hongjia Zhang, Yunpeng Ling, and Feng Lan
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Mesenchymal stem cells ,Cell sheet ,Myocardial infarction ,Regulation of inflammatory response ,Ventricular remodelling ,Materials of engineering and construction. Mechanics of materials ,TA401-492 ,Biology (General) ,QH301-705.5 - Abstract
Stem cell-based therapy has been used to treat ischaemic heart diseases for two decades. However, optimal cell types and transplantation methods remain unclear. This study evaluated the therapeutic effects of human umbilical cord mesenchymal stem cell (hUCMSC) sheet on myocardial infarction (MI). Methods: hUCMSCs expressing luciferase were generated by lentiviral transduction for in vivo bio-luminescent imaging tracking of cells. We applied a temperature-responsive cell culture surface-based method to form the hUCMSC sheet. Cell retention was evaluated using an in vivo bio-luminescent imaging tracking system. Unbiased transcriptional profiling of infarcted hearts and further immunohistochemical assessment of monocyte and macrophage subtypes were used to determine the mechanisms underlying the therapeutic effects of the hUCMSC sheet. Echocardiography and pathological analyses of heart sections were performed to evaluate cardiac function, angiogenesis and left ventricular remodelling. Results: When transplanted to the infarcted mouse hearts, hUCMSC sheet significantly improved the retention and survival compared with cell suspension. At the early stage of MI, hUCMSC sheet modulated inflammation by decreasing Mcp1-positive monocytes and CD68-positive macrophages and increasing Cx3cr1-positive non-classical macrophages, preserving the cardiomyocytes from acute injury. Moreover, the extracellular matrix produced by hUCMSC sheet then served as bioactive scaffold for the host cells to graft and generate new epicardial tissue, providing mechanical support and routes for revascularsation. These effects of hUCMSC sheet treatment significantly improved the cardiac function at days 7 and 28 post-MI. Conclusions: hUCMSC sheet formation dramatically improved the biological functions of hUCMSCs, mitigating adverse post-MI remodelling by modulating the inflammatory response and providing bioactive scaffold upon transplantation into the heart. Translational perspective: Due to its excellent availability as well as superior local cellular retention and survival, allogenic transplantation of hUCMSC sheets can more effectively acquire the biological functions of hUCMSCs, such as modulating inflammation and enhancing angiogenesis. Moreover, the hUCMSC sheet method allows the transfer of an intact extracellular matrix without introducing exogenous or synthetic biomaterial, further improving its clinical applicability.
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- 2021
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30. Application of Human-Computer Interaction Technology in Ancillary Diagnosis of Nervous System Diseases: Current Situation and Prospect
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LI Yang, WANG Liuping, HUANG Jin, FAN Xiangmin, and TIAN Feng
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human-computer interaction ,medical treatment ,nervous system diseases ,Medicine - Abstract
With the development of human-computer interaction, how to use intelligent, natural and efficient methods to promote the development of the medical field has become a hot topic of research. Nervous system diseases have a great impact on the quality of people's daily life. Using the method of human-computer interaction for early warning and ancillary diagnosis of nervous system diseases can reduce discomfort of patients during exams and work intensity of doctors, which is of great significance to both doctors and patients. This paper discusses the application status, existing problems, future development of human-computer interaction in the ancillary diagnosis of nervous system diseases, and how to use computer technology to improve traditional medical diagnosis methods from the perspective of interaction.
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- 2021
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31. CNN-Transformer Rectified Collaborative Learning for Medical Image Segmentation
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Wu, Lanhu, Zhang, Miao, Piao, Yongri, Yao, Zhenyan, Sun, Weibing, Tian, Feng, and Lu, Huchuan
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Computer Science - Computer Vision and Pattern Recognition - Abstract
Automatic and precise medical image segmentation (MIS) is of vital importance for clinical diagnosis and analysis. Current MIS methods mainly rely on the convolutional neural network (CNN) or self-attention mechanism (Transformer) for feature modeling. However, CNN-based methods suffer from the inaccurate localization owing to the limited global dependency while Transformer-based methods always present the coarse boundary for the lack of local emphasis. Although some CNN-Transformer hybrid methods are designed to synthesize the complementary local and global information for better performance, the combination of CNN and Transformer introduces numerous parameters and increases the computation cost. To this end, this paper proposes a CNN-Transformer rectified collaborative learning (CTRCL) framework to learn stronger CNN-based and Transformer-based models for MIS tasks via the bi-directional knowledge transfer between them. Specifically, we propose a rectified logit-wise collaborative learning (RLCL) strategy which introduces the ground truth to adaptively select and rectify the wrong regions in student soft labels for accurate knowledge transfer in the logit space. We also propose a class-aware feature-wise collaborative learning (CFCL) strategy to achieve effective knowledge transfer between CNN-based and Transformer-based models in the feature space by granting their intermediate features the similar capability of category perception. Extensive experiments on three popular MIS benchmarks demonstrate that our CTRCL outperforms most state-of-the-art collaborative learning methods under different evaluation metrics.
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- 2024
32. Secure Transmission for Movable Antennas Empowered Cell-Free Symbiotic Radio Communications
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Guan, Jiayu, Lyu, Bin, Liu, Yan, and Tian, Feng
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Electrical Engineering and Systems Science - Signal Processing - Abstract
In this paper, a novel movable antenna (MA) empowered secure transmission scheme is designed for cell-free symbiotic radio (SR) systems in the presence of an eavesdropper (Eve). Specifically, multiple distributed access points (APs) equipped with MAs collaboratively transmit confidential information to the primary user (PU), in the meanwhile the backscatter device (BD) transmits its own information to the secondary user (SU) by reflecting incident signals from the APs. The MAs deployed at the APs can adjust their positions flexibly to improve channel conditions between the APs and the PU/SU/BD and suppress the eavesdropping from the Eve on confidential information at the PU. Under this setup, we maximize the secrecy rate of primary transmission through jointly optimizing the APs' transmission beamforming vectors and the positions of the MAs, while adhering to the quality of service constraints at the SU. To address the challenges caused by the non-convexity and find a near-optimal solution, an alternating optimization (AO) framework is proposed, utilizing the successive convex approximation method, the semi-definite relaxation technology and a genetic algorithm modified particle swarm optimization (GA-PSO) algorithm. Numerical results demonstrate the secrecy rate enhancement provided by utilizing the MAs and show the impact of the GA-PSO algorithm for improving the solving accuracy., Comment: 7 pages, 6 figures
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- 2024
33. The Llama 3 Herd of Models
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Dubey, Abhimanyu, Jauhri, Abhinav, Pandey, Abhinav, Kadian, Abhishek, Al-Dahle, Ahmad, Letman, Aiesha, Mathur, Akhil, Schelten, Alan, Yang, Amy, Fan, Angela, Goyal, Anirudh, Hartshorn, Anthony, Yang, Aobo, Mitra, Archi, Sravankumar, Archie, Korenev, Artem, Hinsvark, Arthur, Rao, Arun, Zhang, Aston, Rodriguez, Aurelien, Gregerson, Austen, Spataru, Ava, Roziere, Baptiste, Biron, Bethany, Tang, Binh, Chern, Bobbie, Caucheteux, Charlotte, Nayak, Chaya, Bi, Chloe, Marra, Chris, McConnell, Chris, Keller, Christian, Touret, Christophe, Wu, Chunyang, Wong, Corinne, Ferrer, Cristian Canton, Nikolaidis, Cyrus, Allonsius, Damien, Song, Daniel, Pintz, Danielle, Livshits, Danny, Esiobu, David, Choudhary, Dhruv, Mahajan, Dhruv, Garcia-Olano, Diego, Perino, Diego, Hupkes, Dieuwke, Lakomkin, Egor, AlBadawy, Ehab, Lobanova, Elina, Dinan, Emily, Smith, Eric Michael, Radenovic, Filip, Zhang, Frank, Synnaeve, Gabriel, Lee, Gabrielle, Anderson, Georgia Lewis, Nail, Graeme, Mialon, Gregoire, Pang, Guan, Cucurell, Guillem, Nguyen, Hailey, Korevaar, Hannah, Xu, Hu, Touvron, Hugo, Zarov, Iliyan, Ibarra, Imanol Arrieta, Kloumann, Isabel, Misra, Ishan, Evtimov, Ivan, Copet, Jade, Lee, Jaewon, Geffert, Jan, Vranes, Jana, Park, Jason, Mahadeokar, Jay, Shah, Jeet, van der Linde, Jelmer, Billock, Jennifer, Hong, Jenny, Lee, Jenya, Fu, Jeremy, Chi, Jianfeng, Huang, Jianyu, Liu, Jiawen, Wang, Jie, Yu, Jiecao, Bitton, Joanna, Spisak, Joe, Park, Jongsoo, Rocca, Joseph, Johnstun, Joshua, Saxe, Joshua, Jia, Junteng, Alwala, Kalyan Vasuden, Upasani, Kartikeya, Plawiak, Kate, Li, Ke, Heafield, Kenneth, Stone, Kevin, El-Arini, Khalid, Iyer, Krithika, Malik, Kshitiz, Chiu, Kuenley, Bhalla, Kunal, Rantala-Yeary, Lauren, van der Maaten, Laurens, Chen, Lawrence, Tan, Liang, Jenkins, Liz, Martin, Louis, Madaan, Lovish, Malo, Lubo, Blecher, Lukas, Landzaat, Lukas, de Oliveira, Luke, Muzzi, Madeline, Pasupuleti, Mahesh, Singh, Mannat, Paluri, Manohar, Kardas, Marcin, Oldham, Mathew, Rita, Mathieu, Pavlova, Maya, Kambadur, Melanie, Lewis, Mike, Si, Min, Singh, Mitesh Kumar, Hassan, Mona, Goyal, Naman, Torabi, Narjes, Bashlykov, Nikolay, Bogoychev, Nikolay, Chatterji, Niladri, Duchenne, Olivier, Çelebi, Onur, Alrassy, Patrick, Zhang, Pengchuan, Li, Pengwei, Vasic, Petar, Weng, Peter, Bhargava, Prajjwal, Dubal, Pratik, Krishnan, Praveen, Koura, Punit Singh, Xu, Puxin, He, Qing, Dong, Qingxiao, Srinivasan, Ragavan, Ganapathy, Raj, Calderer, Ramon, Cabral, Ricardo Silveira, Stojnic, Robert, Raileanu, Roberta, Girdhar, Rohit, Patel, Rohit, Sauvestre, Romain, Polidoro, Ronnie, Sumbaly, Roshan, Taylor, Ross, Silva, Ruan, Hou, Rui, Wang, Rui, Hosseini, Saghar, Chennabasappa, Sahana, Singh, Sanjay, Bell, Sean, Kim, Seohyun Sonia, Edunov, Sergey, Nie, Shaoliang, Narang, Sharan, Raparthy, Sharath, Shen, Sheng, Wan, Shengye, Bhosale, Shruti, Zhang, Shun, Vandenhende, Simon, Batra, Soumya, Whitman, Spencer, Sootla, Sten, Collot, Stephane, Gururangan, Suchin, Borodinsky, Sydney, Herman, Tamar, Fowler, Tara, Sheasha, Tarek, Georgiou, Thomas, Scialom, Thomas, Speckbacher, Tobias, Mihaylov, Todor, Xiao, Tong, Karn, Ujjwal, Goswami, Vedanuj, Gupta, Vibhor, Ramanathan, Vignesh, Kerkez, Viktor, Gonguet, Vincent, Do, Virginie, Vogeti, Vish, Petrovic, Vladan, Chu, Weiwei, Xiong, Wenhan, Fu, Wenyin, Meers, Whitney, Martinet, Xavier, Wang, Xiaodong, Tan, Xiaoqing Ellen, Xie, Xinfeng, Jia, Xuchao, Wang, Xuewei, Goldschlag, Yaelle, Gaur, Yashesh, Babaei, Yasmine, Wen, Yi, Song, Yiwen, Zhang, Yuchen, Li, Yue, Mao, Yuning, Coudert, Zacharie Delpierre, Yan, Zheng, Chen, Zhengxing, Papakipos, Zoe, Singh, Aaditya, Grattafiori, Aaron, Jain, Abha, Kelsey, Adam, Shajnfeld, Adam, Gangidi, Adithya, Victoria, Adolfo, Goldstand, Ahuva, Menon, Ajay, Sharma, Ajay, Boesenberg, Alex, Vaughan, Alex, Baevski, Alexei, Feinstein, Allie, Kallet, Amanda, Sangani, Amit, Yunus, Anam, Lupu, Andrei, Alvarado, Andres, Caples, Andrew, Gu, Andrew, Ho, Andrew, Poulton, Andrew, Ryan, Andrew, Ramchandani, Ankit, Franco, Annie, Saraf, Aparajita, Chowdhury, Arkabandhu, Gabriel, Ashley, Bharambe, Ashwin, Eisenman, Assaf, Yazdan, Azadeh, James, Beau, Maurer, Ben, Leonhardi, Benjamin, Huang, Bernie, Loyd, Beth, De Paola, Beto, Paranjape, Bhargavi, Liu, Bing, Wu, Bo, Ni, Boyu, Hancock, Braden, Wasti, Bram, Spence, Brandon, Stojkovic, Brani, Gamido, Brian, Montalvo, Britt, Parker, Carl, Burton, Carly, Mejia, Catalina, Wang, Changhan, Kim, Changkyu, Zhou, Chao, Hu, Chester, Chu, Ching-Hsiang, Cai, Chris, Tindal, Chris, Feichtenhofer, Christoph, Civin, Damon, Beaty, Dana, Kreymer, Daniel, Li, Daniel, Wyatt, Danny, Adkins, David, Xu, David, Testuggine, Davide, David, Delia, Parikh, Devi, Liskovich, Diana, Foss, Didem, Wang, Dingkang, Le, Duc, Holland, Dustin, Dowling, Edward, Jamil, Eissa, Montgomery, Elaine, Presani, Eleonora, Hahn, Emily, Wood, Emily, Brinkman, Erik, Arcaute, Esteban, Dunbar, Evan, Smothers, Evan, Sun, Fei, Kreuk, Felix, Tian, Feng, Ozgenel, Firat, Caggioni, Francesco, Guzmán, Francisco, Kanayet, Frank, Seide, Frank, Florez, Gabriela Medina, Schwarz, Gabriella, Badeer, Gada, Swee, Georgia, Halpern, Gil, Thattai, Govind, Herman, Grant, Sizov, Grigory, Guangyi, Zhang, Lakshminarayanan, Guna, Shojanazeri, Hamid, Zou, Han, Wang, Hannah, Zha, Hanwen, Habeeb, Haroun, Rudolph, Harrison, Suk, Helen, Aspegren, Henry, Goldman, Hunter, Damlaj, Ibrahim, Molybog, Igor, Tufanov, Igor, Veliche, Irina-Elena, Gat, Itai, Weissman, Jake, Geboski, James, Kohli, James, Asher, Japhet, Gaya, Jean-Baptiste, Marcus, Jeff, Tang, Jeff, Chan, Jennifer, Zhen, Jenny, Reizenstein, Jeremy, Teboul, Jeremy, Zhong, Jessica, Jin, Jian, Yang, Jingyi, Cummings, Joe, Carvill, Jon, Shepard, Jon, McPhie, Jonathan, Torres, Jonathan, Ginsburg, Josh, Wang, Junjie, Wu, Kai, U, Kam Hou, Saxena, Karan, Prasad, Karthik, Khandelwal, Kartikay, Zand, Katayoun, Matosich, Kathy, Veeraraghavan, Kaushik, Michelena, Kelly, Li, Keqian, Huang, Kun, Chawla, Kunal, Lakhotia, Kushal, Huang, Kyle, Chen, Lailin, Garg, Lakshya, A, Lavender, Silva, Leandro, Bell, Lee, Zhang, Lei, Guo, Liangpeng, Yu, Licheng, Moshkovich, Liron, Wehrstedt, Luca, Khabsa, Madian, Avalani, Manav, Bhatt, Manish, Tsimpoukelli, Maria, Mankus, Martynas, Hasson, Matan, Lennie, Matthew, Reso, Matthias, Groshev, Maxim, Naumov, Maxim, Lathi, Maya, Keneally, Meghan, Seltzer, Michael L., Valko, Michal, Restrepo, Michelle, Patel, Mihir, Vyatskov, Mik, Samvelyan, Mikayel, Clark, Mike, Macey, Mike, Wang, Mike, Hermoso, Miquel Jubert, Metanat, Mo, Rastegari, Mohammad, Bansal, Munish, Santhanam, Nandhini, Parks, Natascha, White, Natasha, Bawa, Navyata, Singhal, Nayan, Egebo, Nick, Usunier, Nicolas, Laptev, Nikolay Pavlovich, Dong, Ning, Zhang, Ning, Cheng, Norman, Chernoguz, Oleg, Hart, Olivia, Salpekar, Omkar, Kalinli, Ozlem, Kent, Parkin, Parekh, Parth, Saab, Paul, Balaji, Pavan, Rittner, Pedro, Bontrager, Philip, Roux, Pierre, Dollar, Piotr, Zvyagina, Polina, Ratanchandani, Prashant, Yuvraj, Pritish, Liang, Qian, Alao, Rachad, Rodriguez, Rachel, Ayub, Rafi, Murthy, Raghotham, Nayani, Raghu, Mitra, Rahul, Li, Raymond, Hogan, Rebekkah, Battey, Robin, Wang, Rocky, Maheswari, Rohan, Howes, Russ, Rinott, Ruty, Bondu, Sai Jayesh, Datta, Samyak, Chugh, Sara, Hunt, Sara, Dhillon, Sargun, Sidorov, Sasha, Pan, Satadru, Verma, Saurabh, Yamamoto, Seiji, Ramaswamy, Sharadh, Lindsay, Shaun, Feng, Sheng, Lin, Shenghao, Zha, Shengxin Cindy, Shankar, Shiva, Zhang, Shuqiang, Wang, Sinong, Agarwal, Sneha, Sajuyigbe, Soji, Chintala, Soumith, Max, Stephanie, Chen, Stephen, Kehoe, Steve, Satterfield, Steve, Govindaprasad, Sudarshan, Gupta, Sumit, Cho, Sungmin, Virk, Sunny, Subramanian, Suraj, Choudhury, Sy, Goldman, Sydney, Remez, Tal, Glaser, Tamar, Best, Tamara, Kohler, Thilo, Robinson, Thomas, Li, Tianhe, Zhang, Tianjun, Matthews, Tim, Chou, Timothy, Shaked, Tzook, Vontimitta, Varun, Ajayi, Victoria, Montanez, Victoria, Mohan, Vijai, Kumar, Vinay Satish, Mangla, Vishal, Albiero, Vítor, Ionescu, Vlad, Poenaru, Vlad, Mihailescu, Vlad Tiberiu, Ivanov, Vladimir, Li, Wei, Wang, Wenchen, Jiang, Wenwen, Bouaziz, Wes, Constable, Will, Tang, Xiaocheng, Wang, Xiaofang, Wu, Xiaojian, Wang, Xiaolan, Xia, Xide, Wu, Xilun, Gao, Xinbo, Chen, Yanjun, Hu, Ye, Jia, Ye, Qi, Ye, Li, Yenda, Zhang, Yilin, Zhang, Ying, Adi, Yossi, Nam, Youngjin, Yu, Wang, Hao, Yuchen, Qian, Yundi, He, Yuzi, Rait, Zach, DeVito, Zachary, Rosnbrick, Zef, Wen, Zhaoduo, Yang, Zhenyu, and Zhao, Zhiwei
- Subjects
Computer Science - Artificial Intelligence ,Computer Science - Computation and Language ,Computer Science - Computer Vision and Pattern Recognition - Abstract
Modern artificial intelligence (AI) systems are powered by foundation models. This paper presents a new set of foundation models, called Llama 3. It is a herd of language models that natively support multilinguality, coding, reasoning, and tool usage. Our largest model is a dense Transformer with 405B parameters and a context window of up to 128K tokens. This paper presents an extensive empirical evaluation of Llama 3. We find that Llama 3 delivers comparable quality to leading language models such as GPT-4 on a plethora of tasks. We publicly release Llama 3, including pre-trained and post-trained versions of the 405B parameter language model and our Llama Guard 3 model for input and output safety. The paper also presents the results of experiments in which we integrate image, video, and speech capabilities into Llama 3 via a compositional approach. We observe this approach performs competitively with the state-of-the-art on image, video, and speech recognition tasks. The resulting models are not yet being broadly released as they are still under development.
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- 2024
34. Knowledge Acquisition Disentanglement for Knowledge-based Visual Question Answering with Large Language Models
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An, Wenbin, Tian, Feng, Nie, Jiahao, Shi, Wenkai, Lin, Haonan, Chen, Yan, Wang, QianYing, Wu, Yaqiang, Dai, Guang, and Chen, Ping
- Subjects
Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Computation and Language ,Computer Science - Multimedia - Abstract
Knowledge-based Visual Question Answering (KVQA) requires both image and world knowledge to answer questions. Current methods first retrieve knowledge from the image and external knowledge base with the original complex question, then generate answers with Large Language Models (LLMs). However, since the original question contains complex elements that require knowledge from different sources, acquiring different kinds of knowledge in a coupled manner may confuse models and hinder them from retrieving precise knowledge. Furthermore, the ``forward-only'' answering process fails to explicitly capture the knowledge needs of LLMs, which can further hurt answering quality. To cope with the above limitations, we propose DKA: Disentangled Knowledge Acquisition from LLM feedback, a training-free framework that disentangles knowledge acquisition to avoid confusion and uses LLM's feedback to specify the required knowledge. Specifically, DKA requires LLMs to specify what knowledge they need to answer the question and decompose the original complex question into two simple sub-questions: Image-based sub-question and Knowledge-based sub-question. Then we use the two sub-questions to retrieve knowledge from the image and knowledge base, respectively. In this way, two knowledge acquisition models can focus on the content that corresponds to them and avoid disturbance of irrelevant elements in the original complex question, which can help to provide more precise knowledge and better align the knowledge needs of LLMs to yield correct answers. Experiments on benchmark datasets show that DKA significantly outperforms SOTA models. To facilitate future research, our data and code are available at \url{https://github.com/Lackel/DKA}., Comment: Pre-print
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- 2024
35. Timestep-Aware Correction for Quantized Diffusion Models
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Yao, Yuzhe, Tian, Feng, Chen, Jun, Lin, Haonan, Dai, Guang, Liu, Yong, and Wang, Jingdong
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Computer Science - Computer Vision and Pattern Recognition - Abstract
Diffusion models have marked a significant breakthrough in the synthesis of semantically coherent images. However, their extensive noise estimation networks and the iterative generation process limit their wider application, particularly on resource-constrained platforms like mobile devices. Existing post-training quantization (PTQ) methods have managed to compress diffusion models to low precision. Nevertheless, due to the iterative nature of diffusion models, quantization errors tend to accumulate throughout the generation process. This accumulation of error becomes particularly problematic in low-precision scenarios, leading to significant distortions in the generated images. We attribute this accumulation issue to two main causes: error propagation and exposure bias. To address these problems, we propose a timestep-aware correction method for quantized diffusion model, which dynamically corrects the quantization error. By leveraging the proposed method in low-precision diffusion models, substantial enhancement of output quality could be achieved with only negligible computation overhead. Extensive experiments underscore our method's effectiveness and generalizability. By employing the proposed correction strategy, we achieve state-of-the-art (SOTA) results on low-precision models., Comment: ECCV 2024
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- 2024
36. Reducing culture medium nitrogen supply coupled with replenishing carbon nutrient simultaneously enhances the biomass and lipid production of Chlamydomonas reinhardtii
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Shiyan Zheng, Shangyun Zou, Hongyan Wang, Tian Feng, Shourui Sun, Hui Chen, and Qiang Wang
- Subjects
Chlamydomonas reinhardtii ,carbon and nitrogen levels ,lipid production ,microalgal biomass ,fatty acid compositions ,Microbiology ,QR1-502 - Abstract
Chlamydomonas reinhardtii is a model strain to explore algal lipid metabolism mechanism, and exhibits great potentials in large-scale production of lipids. Completely lacking nitrogen is an efficient strategy to trigger the lipid synthesis in microalgal cells, while it always leads to the obvious reduction in the biomass. To illustrate the optimal culture substrate carbon (C) and nitrogen (N) levels to simultaneously stimulate the growth and lipid production of C. reinhardtii, cells were cultivated under altered C and N concentrations. Results showed that replenishing 6 g/L sodium acetate (NaAc) could increase 1.50 and 1.53 times biomass and lipid productivity compared with 0 g/L NaAc treatment (the control), but total lipid content slightly decreased. Reducing 75% of basic medium (TAP) N level (0 g/L NaAc + 0.09 g/L NH4Cl treatment) could promote 21.57% total lipid content in comparison with the control (containing 0.38 g/L NH4Cl), but decrease 44.45% biomass and 34.15% lipid productivity. The result of the central composite design (CCD) experiment suggested the optimum total lipid content together with higher biomass and lipid productivity could be obtained under the condition of 4.12 g/L NaAc and 0.20 g/L NH4Cl. They reached 32.14%, 1.68 g/L and 108.21 mg/L/d, and increased by 36.77%, 93.10% and 1.75 times compared with the control, respectively. It suggests moderately increasing C supply and decreasing N levels could synchronously improve the biomass and lipid content of C. reinhardtii.
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- 2022
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37. Foot-and-mouth disease virus VP1 promotes viral replication by regulating the expression of chemokines and GBP1
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Li Yang, Hong Chen, Liqing Liu, Jingjing Song, Tian Feng, Yihan Li, Chao Shen, Lingbao Kong, and Xiu Xin
- Subjects
RNA-seq ,transcriptome ,gene expression ,FMDV VP1 ,cytokine ,GBP1 ,Veterinary medicine ,SF600-1100 - Abstract
Foot-and-mouth disease virus (FMDV) is an acute, highly contagious, and economically destructive pathogen of vesicular disease that affects domestic and wild cloven-hoofed animals. The FMDV VP1 protein is an important part of the nucleocapsid and plays a significant role during FMDV infection. However, the signal pathways mediated by VP1 in the life cycle of FMDV and the related mechanisms are not yet fully understood. Here, we performed RNA-seq to compare gene expression profiles between pCAGGS-HA-VP1 transfected PK-15 cells and pCAGGS-HA (empty vector) transfected PK-15 cells. The results showed 5,571 genes with significantly different expression levels, of which 2,981 were up-regulated and 2,590 were down-regulated. GO enrichment analysis showed that 51 GO terms were significantly enriched in cell components including protein complex, membrane and organelle part. KEGG enrichment analysis showed 11 KEGG pathways were significantly enriched which were mainly related to the immune system, infectious viral disease, and signal transduction. Among the up-regulated genes, the chemokines such as CCL5, CXCL8, and CXCL10 in turn promoted FMDV replication. In contrast, GBP1, an interferon-stimulated gene that was suppressed by VP1 and FMDV, could effectively inhibit FMDV replication. Our research provides a comprehensive overview of the response of host cells to VP1 protein and a basis for further research to understand the roles of VP1 in FMDV infection including the genes involved in FMDV replication.
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- 2022
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38. Storm Surge Inundation Modulated by Typhoon Intensities and Tracks: Simulations Using the Regional Ocean Modeling System (ROMS)
- Author
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Gangri Qin, Zhen Fang, Shuyu Zhao, Yanjiahui Meng, Weiwei Sun, Gang Yang, Lihua Wang, and Tian Feng
- Subjects
ROMS ,typhoon storm surges inundation ,Holland model ,Ningbo ,Naval architecture. Shipbuilding. Marine engineering ,VM1-989 ,Oceanography ,GC1-1581 - Abstract
Storm surges are one of the most severe marine hazards, causing fatalities and devastating infrastructure. It is important to conduct research on storm surge hazards to achieve disaster avoidance and the protection of local populations. In this study, the Regional Ocean Modeling System (ROMS) was used to develop a framework to simulate the inundation (using the wet/dry method) of land in Ningbo, China during an extreme typhoon storm surge. The baseline simulation with the realistic typhoon intensity and track was well validated by meteorological and ocean tidal observations. Using reanalysis and an asymmetric typhoon wind field from the Holland model as atmospheric forcing, we presented different storm surge inundation scenarios regarding various intensities and tracks. The results revealed that typhoon storm surges are significantly affected by both the intensities and tracks of typhoons. Specifically, when Ningbo was located in the navigable semicircle, increasing the typhoon intensity not only resulted in the total inundation area of the whole study area from 108.57 km2 to 139.97 km2, but also led to significant negative storm surges in some sea areas. When Ningbo was exposed to the dangerous semicircle of the intensified typhoon, the storm surge along the coast of the Xiangshan Bay could exceed 4 m, amplifying the total inundation area to 245.41 km2. Thus, it was evident that the location of the impacted region within the typhoon’s wind field plays a critical role in determining the severity of the storm surge. These results provide valuable suggestions for storm surge disaster prevention and mitigation for local governments.
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- 2023
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39. Serpentinization-Associated Mineral Catalysis of the Protometabolic Formose System
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Arthur Omran, Asbell Gonzalez, Cesar Menor-Salvan, Michael Gaylor, Jing Wang, Jerzy Leszczynski, and Tian Feng
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serpentinization ,chemical garden ,hydrothermal environments ,formose reaction ,prebiotic chemistry ,metabolism ,Science - Abstract
The formose reaction is a plausible prebiotic chemistry, famed for its production of sugars. In this work, we demonstrate that the Cannizzaro process is the dominant process in the formose reaction under many different conditions, thus necessitating a catalyst for the formose reaction under various environmental circumstances. The investigated formose reactions produce primarily organic acids associated with metabolism, a protometabolic system, and yield very little sugar left over. This is due to many of the acids forming from the degradation and Cannizaro reactions of many of the sugars produced during the formose reaction. We also show the heterogeneous Lewis-acid-based catalysis of the formose reaction by mineral systems associated with serpentinization. The minerals that showed catalytic activity include olivine, serpentinite, and calcium, and magnesium minerals including dolomite, calcite, and our Ca/Mg-chemical gardens. In addition, computational studies were performed for the first step of the formose reaction to investigate the reaction of formaldehyde, to either form methanol and formic acid under a Cannizzaro reaction or to react to form glycolaldehyde. Here, we postulate that serpentinization is therefore the startup process necessary to kick off a simple proto metabolic system—the formose protometabolic system.
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- 2023
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40. A Twenty-Year Assessment of Spatiotemporal Variation of Surface Temperature in the Yangtze River Delta, China
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Quan Zhang, Tian Feng, Mengen Wang, Gang Yang, Huimin Lu, and Weiwei Sun
- Subjects
land surface temperature ,trend decomposition ,breakpoints ,Yangtze River Delta ,Science - Abstract
A good understanding of the processes of land surface temperature (LST) change is important for assessing regional climate change. In the present study, we obtained the MODIS MOD11A2 LST products over the Yangtze River Delta (YRD) from 2001 to 2020. In order to comprehensively assess the spatial and temporal variability of LST in the YRD region over the past two decades, the Theil–Sen Median trend analysis and Mann–Kendall test, BFAST01 trend decomposition, and landscape pattern analysis were used in this study. We show that the rate of linear change in LST in the YRD ranges from −0.019 °C/month to 0.046 °C/month. The BFAST01 trend decomposition identifies more details of LST change and monotonic increases, reversal increase, and interruption increase are the main warming trends. The distribution of the different trend types shows strong aggregation with high spatial heterogeneity. The LST breakpoints are mainly located in the northern and southern YRD, which frequently occurred during 2010–2013. Of the various land types, breakpoints occur most frequently in cropland and high NDVI (0.5–0.7) areas, and the intensity of most of them is within 2 °C. In addition, much stronger warming occurs in urban areas than in other land types. Our study provides a better understanding of the dynamics of LST in the YRD region over the past 20 years and highlights that breakpoints cannot be circumvented in regional temperature assessment.
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- 2023
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41. Agreement evaluation of an automatic segmentation algorithm for quantifying subdural/epidural hemorrhage volume using convolution neural network
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TIAN Feng⁃xuan, CHANG Jian⁃bo, CHEN Yi⁃hao, WEI Jun⁃ji, FENG Ming, WANG Ren⁃zhi, and HE Xi⁃wu
- Subjects
hematoma ,subdural ,epidural ,cranial ,artificial intelligence ,neural networks (computer) ,tomography ,x⁃ray computed ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Objective To validate the agreement among the convolution neural network segmentation algorithm, Tada formula and manual segmentation for subdural/epidural hemorrhage volume. Methods A total of 129 cases with 352 subdural/epidural hemorrhage CT scans were extracted from Chinese Intracranial Hemorrhage Image Database (CICHID) from January 2017 to June 2019. All CT scans were measured by three methods including manual segmentation, algorithm segmentation and Tada formula. The manual segmentation was regarded as the "golden standard" and the agreement test among three methods was performed. We explored the influence factors in different measurement methods, such as the shape or boundary of hematoma. Results Compared with the Tada formula method, the percentage error of segmentation algorithm was small (23.62%), and the agreement between algorithm and the manual reference was strong, which 94.89% (334/352) of the data was within the 95% limits of agreement (95%LoA), however, the 95%LoA was broad. And the performance of segmentation algorithm showed better in asymmetry (P = 0.000) and clear boundary hematoma (P = 0.000). Conclusions The segmentation algorithm based on convolution neural network has a certain application prospect, but need to be validated in large sample research. doi:10.3969/j.issn.1672⁃6731.2021.03.011
- Published
- 2021
42. Hepatectomy combined with postoperative postural drainage for hepatolithiasis with right posteroinferior bile duct angulation
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CHEN Guanyu, TIAN Feng, HE Yu, ZHANG Leida, LI Dajiang, and WANG Shuguang
- Subjects
hepatolithiasis ,recurrence of stone ,angulation of right posteroinferior bile duct ,postural drainage ,Medicine (General) ,R5-920 - Abstract
Objective We found that the angle between the right posteroinferior bile duct and the longitudinal axis of the human body was smaller in the patients with stones in the bile duct. This study aimed to reveal the effect of hepatectomy combined with postoperative postural drainage for hepatolithiasis with right posteroinferior bile duct angulation. Methods All the patients with stones in the right posteroinferior bile duct and the angle mentioned above < 44.58°admitted into our institute from January 2011 to July 2016 were enrolled in the retrospective study. According to undergoing the postural drainage after surgery or not, they were divided into control group (n=81) and drainage group (n=84). Clinical data, intraoperative indexes, postoperative outcome, incidence of complications, and recurrence of bile duct stone were analyzed and compared between the 2 groups. Results There were no significant differences in preoperative general characteristics and surgical complications between the control group and postural drainage group. But the former group had obviously higher stone recurrence rate (P < 0.001), recurrence rate of acute cholangitis (P < 0.001), and cumulative recurrence rates of right posteroinferior bile duct stone (P=0.021) when compared with latter group during the follow-up period. Conclusion Hepatectomy combined with postoperative postural drainage can effectively reduce the recurrence rate of postoperative cholangitis and bile duct stone in patients with hepatolithiasis accompanied by angulation of the right posteroinferior bile duct.
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- 2021
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43. Prebiotic Chemistry of Phosphite: Mild Thermal Routes to Form Condensed-P Energy Currency Molecules Leading Up to the Formation of Organophosphorus Compounds
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Maheen Gull, Tian Feng, Harold A. Cruz, Ramanarayanan Krishnamurthy, and Matthew A. Pasek
- Subjects
phosphite ,phosphorus ,organophosphorus compounds ,origin of life ,condensed phosphates ,condensation ,Science - Abstract
The in-fall of meteorites and interstellar dust particles during the Hadean–Archean heavy bombardment may have provided the early Earth with various reduced oxidation state phosphorus compounds and minerals, including phosphite (HPO32−)([Pi(III)]). The ion phosphite ([Pi(III)])has been postulated to be ubiquitous on the early Earth and consequently could have played a role in the emergence of organophosphorus compounds and other prebiotically relevant P species such as condensed P compounds, e.g., pyrophosphite ([PPi(III)]) and isohypophosphate ([PPi(III–V)]). In the present study, we show that phosphite ([Pi(III)]) oxidizes under mild heating conditions (e.g., wet–dry cycles and a prebiotic scenario mimicking a mildly hot-evaporating/drying pool on the early Earth at 78–83 °C) in the presence of urea and other additives, resulting in changes to orthophosphate ([Pi(V)]) alongside the formation of reactive condensed P compounds (e.g., pyrophosphite ([PPi(III)]) and isohypophosphate ([PPi(III–V)])) through a one-pot mechanism. Additionally, we also show that phosphite ([Pi(III)]) and the condensed P compounds readily react with organics (nucleosides and organic alcohol) to form organophosphorus compounds.
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- 2023
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44. Recovery efficiency and characteristics of long core by CO2 flooding in low permeability sandstone reservoirs
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Tian Feng and Li Tiantai
- Subjects
Environmental sciences ,GE1-350 - Abstract
CO2 flooding is an economical and efficient enhanced oil recovery technology, however, it is difficult for conventional short core experiments to provide accurate parameters for the later on-site optimization scheme. In this paper, on the basis of long core flooding experiments and applying NMR technology, we quantitatively evaluated the recovery efficiency and remaining oil distribution characteristics by CO2 in low-permeability sandstone reservoirs from a microscopic perspective, and explored the potential of CO2 flooding in low-permeability sandstone reservoirs. Results showed that with the CO2 injection pressure increase, the recovery efficiency of the long core increased and the ultimate recovery was 65.3%. Recovery efficiency of short cores at the inlet, middle and outlet decreases successively, but the change range was not large, and all of them are around the recovery efficiency of long core. In addition, at low injection pressure, almost all CO2 went into the larger pores to replace oil. As increased pressure, the oil started to be produced from the smaller pores, but at 22 MPa, the recovery efficiency in larger pores (76.88%-83.38%) was still higher than that of smaller pores (68.73%-72.74%). Which provided a guide for optimizing the CO2 enhanced oil recovery method in the field.
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- 2023
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45. Integrating the effects of driving forces on ecosystem services into ecological management: A case study from Sichuan Province, China.
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Ying Huang, Tian Feng, Shaofei Niu, Desheng Hao, Xiaoyu Gan, and Bo Zhou
- Subjects
Medicine ,Science - Abstract
Driving forces are the factors that lead to the observed changes in the quantity and quality of ecosystem services (ESs). The relationship between driving forces and ESs involves considerable scale-related information. Place-based ecological management requires this information to support local sustainable development. Despite the importance of scale in ES research, most studies have only examined the association between ESs and their drivers at a single level, and few studies have examined this relationship at various scales or analyzed spatial heterogeneity. The purpose of this paper is to explore the significance of the scale-dependent effects of drivers on ESs for localized ecological management. The biophysical values of ESs were calculated using several ecological simulation models. The effects of driving forces on ESs were explored using the geographically weighted regression (GWR) model. Variations in the effects of driving forces on ESs were examined at three scales: provincial, ecoregional, and subecoregional scales. Finally, canonical correlation analysis was used to identify the major environmental factors associated with these variations in each ecoregion. Our results show that (1) the distribution of soil conservation and water yield is highly heterogeneous; (2) four driving forces have significant positive and negative impacts on soil conservation and water yield, and their effects on the two services vary spatially (p < 0.05); (3) the impacts of drivers on ESs vary across different spatial scales, with a corresponding shift in the related environmental factors; and (4) in the study area, at the provincial scale, physical, topographical, and biophysical factors were key factors associated with the variations in the relationship between ESs and drivers, and at the ecoregional and subecoregional scales, physical, socioeconomic, topographical, and biophysical factors all contributed to these changes. Our results suggest that significant differences in topographical conditions (e.g., altitude, slope) can be incorporated for exploring the relationship between drivers and ESs and optimizing ecological management at the provincial scale, whereas significant differences in physical and socioeconomic conditions (e.g., urbanization levels, human activity, vegetation coverage) are more meaningful for localized ecological management at the ecoregional and subecological scales. These findings provide a basis for understanding the relationship between drivers and ESs at multiple scales as well as guidelines for improving localized ecological management and achieving sustainable development.
- Published
- 2022
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- View/download PDF
46. AGLA: Mitigating Object Hallucinations in Large Vision-Language Models with Assembly of Global and Local Attention
- Author
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An, Wenbin, Tian, Feng, Leng, Sicong, Nie, Jiahao, Lin, Haonan, Wang, QianYing, Dai, Guang, Chen, Ping, and Lu, Shijian
- Subjects
Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Artificial Intelligence ,Computer Science - Computation and Language - Abstract
Despite their great success across various multimodal tasks, Large Vision-Language Models (LVLMs) are facing a prevalent problem with object hallucinations, where the generated textual responses are inconsistent with ground-truth objects in the given image. This paper investigates various LVLMs and pinpoints attention deficiency toward discriminative local image features as one root cause of object hallucinations. Specifically, LVLMs predominantly attend to prompt-independent global image features, while failing to capture prompt-relevant local features, consequently undermining the visual grounding capacity of LVLMs and leading to hallucinations. To this end, we propose Assembly of Global and Local Attention (AGLA), a training-free and plug-and-play approach that mitigates object hallucinations by exploring an ensemble of global features for response generation and local features for visual discrimination simultaneously. Our approach exhibits an image-prompt matching scheme that captures prompt-relevant local features from images, leading to an augmented view of the input image where prompt-relevant content is reserved while irrelevant distractions are masked. With the augmented view, a calibrated decoding distribution can be derived by integrating generative global features from the original image and discriminative local features from the augmented image. Extensive experiments show that AGLA consistently mitigates object hallucinations and enhances general perception capability for LVLMs across various discriminative and generative benchmarks. Our code will be released at https://github.com/Lackel/AGLA.
- Published
- 2024
47. Perceiver-Prompt: Flexible Speaker Adaptation in Whisper for Chinese Disordered Speech Recognition
- Author
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Jiang, Yicong, Wang, Tianzi, Xie, Xurong, Liu, Juan, Sun, Wei, Yan, Nan, Chen, Hui, Wang, Lan, Liu, Xunying, and Tian, Feng
- Subjects
Electrical Engineering and Systems Science - Audio and Speech Processing ,Computer Science - Artificial Intelligence ,Computer Science - Sound - Abstract
Disordered speech recognition profound implications for improving the quality of life for individuals afflicted with, for example, dysarthria. Dysarthric speech recognition encounters challenges including limited data, substantial dissimilarities between dysarthric and non-dysarthric speakers, and significant speaker variations stemming from the disorder. This paper introduces Perceiver-Prompt, a method for speaker adaptation that utilizes P-Tuning on the Whisper large-scale model. We first fine-tune Whisper using LoRA and then integrate a trainable Perceiver to generate fixed-length speaker prompts from variable-length inputs, to improve model recognition of Chinese dysarthric speech. Experimental results from our Chinese dysarthric speech dataset demonstrate consistent improvements in recognition performance with Perceiver-Prompt. Relative reduction up to 13.04% in CER is obtained over the fine-tuned Whisper., Comment: Accepted by interspeech 2024
- Published
- 2024
48. Large Language Models Enhanced Sequential Recommendation for Long-tail User and Item
- Author
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Liu, Qidong, Wu, Xian, Zhao, Xiangyu, Wang, Yejing, Zhang, Zijian, Tian, Feng, and Zheng, Yefeng
- Subjects
Computer Science - Information Retrieval ,Computer Science - Computation and Language - Abstract
Sequential recommendation systems (SRS) serve the purpose of predicting users' subsequent preferences based on their past interactions and have been applied across various domains such as e-commerce and social networking platforms. However, practical SRS encounters challenges due to the fact that most users engage with only a limited number of items, while the majority of items are seldom consumed. These challenges, termed as the long-tail user and long-tail item dilemmas, often create obstacles for traditional SRS methods. Mitigating these challenges is crucial as they can significantly impact user satisfaction and business profitability. While some research endeavors have alleviated these issues, they still grapple with issues such as seesaw or noise stemming from the scarcity of interactions. The emergence of large language models (LLMs) presents a promising avenue to address these challenges from a semantic standpoint. In this study, we introduce the Large Language Models Enhancement framework for Sequential Recommendation (LLM-ESR), which leverages semantic embeddings from LLMs to enhance SRS performance without increasing computational overhead. To combat the long-tail item challenge, we propose a dual-view modeling approach that fuses semantic information from LLMs with collaborative signals from traditional SRS. To address the long-tail user challenge, we introduce a retrieval augmented self-distillation technique to refine user preference representations by incorporating richer interaction data from similar users. Through comprehensive experiments conducted on three authentic datasets using three widely used SRS models, our proposed enhancement framework demonstrates superior performance compared to existing methodologies.
- Published
- 2024
49. Effects of γ-irradiation and EDC/NHS modification on property of collagen-chitosan scaffolds
- Author
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DU Ge, WEI Li, LIU Zi-shuang, WU Ji-min, CHEN Zi-hao, and TIAN Feng
- Subjects
collagen-chitosan scaffold ,γ-irradiation ,edc/nhs ,crosslinking ,modification ,Materials of engineering and construction. Mechanics of materials ,TA401-492 - Abstract
With chitosan mass fraction changing from 0% to 50% by 5%, relative to collagen mass, the collagen-chitosan scaffolds were crosslinked by γ-irradiation and EDC/NHS. Fourier transform infrared spectroscopy (FTIR) and SEM were applied to analyze the structure. Water absorption rate, porosity, collagenase degradation and mechanical property were used to detect the properties. The effects of γ-irradiation and EDC/NHS modification on the properties of scaffolds were studied. The results show that both γ-irradiation and EDC/NHS modification induce crosslinking in collagen-chitosan scaffolds and chitosan greatly reduce the damage to molecular structure caused by γ-irradiation.The microstructure crosslinked by γ-irradiation is worse than those crosslinked by EDC/NHS. The optimal chitosan mass fraction is 25% for both γ-irradiation and EDC/NHS. γ-irradiation and EDC/NHS scaffold modification can lead to orientation structure.
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- 2020
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50. Stem cell-derived cell sheet transplantation for heart tissue repair in myocardial infarction
- Author
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Rui Guo, Masatoshi Morimatsu, Tian Feng, Feng Lan, Dehua Chang, Feng Wan, and Yunpeng Ling
- Subjects
Cell sheet ,Cardiac tissue ,Myocardial infarction ,Heart failure ,Cell therapy ,Mesenchymal stem cells ,Medicine (General) ,R5-920 ,Biochemistry ,QD415-436 - Abstract
Abstract Stem cell-derived sheet engineering has been developed as the next-generation treatment for myocardial infarction (MI) and offers attractive advantages in comparison with direct stem cell transplantation and scaffold tissue engineering. Furthermore, induced pluripotent stem cell-derived cell sheets have been indicated to possess higher potential for MI therapy than other stem cell-derived sheets because of their capacity to form vascularized networks for fabricating thickened human cardiac tissue and their long-term therapeutic effects after transplantation in MI. To date, stem cell sheet transplantation has exhibited a dramatic role in attenuating cardiac dysfunction and improving clinical manifestations of heart failure in MI. In this review, we retrospectively summarized the current applications and strategy of stem cell-derived cell sheet technology for heart tissue repair in MI.
- Published
- 2020
- Full Text
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