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32 results on '"Tian, Sidan"'

10. Recent Progress of Oral Functional Nanomaterials for Intestinal Microbiota Regulation.

Author

Li, Wanneng, Zhan, Minle, Wen, Yue, Chen, Yu, Zhang, Zhongchao, Wang, Shuhui, Tian, Dean, and Tian, Sidan

Subjects
GUT microbiome, ORAL drug administration, THERAPEUTICS, HUMAN body, NANOSTRUCTURED materials
Abstract

The gut microbiota is closely associated with human health, and alterations in gut microbiota can influence various physiological and pathological activities in the human body. Therefore, microbiota regulation has become an important strategy in current disease treatment, albeit facing numerous challenges. Nanomaterials, owing to their excellent protective properties, drug release capabilities, targeting abilities, and good biocompatibility, have been widely developed and utilized in pharmaceuticals and dietary fields. In recent years, significant progress has been made in research on utilizing nanomaterials to assist in regulating gut microbiota for disease intervention. This review explores the latest advancements in the application of nanomaterials for microbiota regulation and offers insights into the future development of nanomaterials in modulating gut microbiota. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Targeted Computed Tomography Visualization and Healing of Inflammatory Bowel Disease by Orally Delivered Bacterial-Flagella-Inspired Polydiiododiacetylene Nanofibers

Author

Yin, Mingming, primary, Chen, Yu, additional, Liu, Xiaoming, additional, Tian, Sidan, additional, Zhao, Liyuan, additional, Bai, Yaowei, additional, Wang, Hao, additional, Lin, Jinfeng, additional, Jiang, Dawei, additional, Lei, Ziqiao, additional, Meng, Fanling, additional, Tian, De’an, additional, and Luo, Liang, additional

Published
2023
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19. Hierarchical Vitalization of Oligotyrosine in Mitigating Islet Amyloid Polypeptide Amyloidogenesis through Multivalent Macromolecules with Conformation-Restrained Nanobody Ligands

Author

Xin, Yanru, primary, Wang, Sheng, additional, Liu, Hui, additional, Ke, Huichuan, additional, Tian, Sidan, additional, Cao, Yujuan, additional, Huang, Yuanda, additional, Shang, Yunhu, additional, Jia, Haibo, additional, Su, Li, additional, Yang, Xiangliang, additional, Meng, Fanling, additional, and Luo, Liang, additional

Published
2021
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22. Complete Degradation of a Conjugated Polymer into Green Upcycling Products by Sunlight in Air

Author

Tian, Sidan, Yue, Qiang, Liu, Chenchen, Li, Mengyang, Yin, Mingming, Gao, Yuting, Meng, Fanling, Tang, Benzhong, Luo, Liang, Tian, Sidan, Yue, Qiang, Liu, Chenchen, Li, Mengyang, Yin, Mingming, Gao, Yuting, Meng, Fanling, Tang, Benzhong, and Luo, Liang

Abstract

The rapid development of digital society and artificial intelligence has triggered explosive demands for specialty plastics, especially conjugated polymers that are instrumental for flexible electronics and smart devices. The recycling and degradation of postconsumer conjugated polymers have become more important than ever to reduce the pressure to the environment. Here we report the discovery of an environmentally self-degradable conjugated polymer poly(deca-4,6-diynedioic acid), or PDDA. PDDA is stable in the dark or without oxygen when used as a functional material. However, when exposed to sunlight and air after the service life, PDDA disintegrates rapidly and fully decomposes through photooxidation in a week, yielding biocompatible, value-added succinic acid as a major degradation product. The complete degradation of PDDA into green upcycling products by sunlight in air, without leaving any microplastics, not only renders a pioneering paradigm of environmentally self-degradable conjugated polymers but also inspires developing effective strategies to completely degrade postconsumer conjugated polymers in a natural environment.

Published
2021

23. Maintaining Semantic Information across Generic 3D Model Editing Operations

Author

Tian, Sidan Yao, Xiao Ling, Fiona Nueesch, Gerhard Schrotter, Simon Schubiger, Zheng Fang, Long Ma, and Zhen

Subjects
semantic building information, CityGML, building model, model matching, 3D information maintenance, automatic labeling, 3D user interface
Abstract

Many of today’s data models for 3D applications, such as City Geography Markup Language (CityGML) or Industry Foundation Classes (IFC) encode rich semantic information in addition to the traditional geometry and materials representation. However, 3D editing techniques fall short of maintaining the semantic information across edit operations if they are not tailored to a specific data model. While semantic information is often lost during edit operations, geometry, UV mappings, and materials are usually maintained. This article presents a data model synchronization method that preserves semantic information across editing operation relying only on geometry, UV mappings, and materials. This enables easy integration of existing and future 3D editing techniques with rich data models. The method links the original data model to the edited geometry using point set registration, recovering the existing information based on spatial and UV search methods, and automatically labels the newly created geometry. An implementation of a Level of Detail 3 (LoD3) building editor for the Virtual Singapore project, based on interactive push-pull and procedural generation of façades, verified the method with 30 common editing tasks. The implementation synchronized changes in the 3D geometry with a CityGML data model and was applied to more than 100 test buildings.

Published
2020
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25. Imaging Chemical Kinetics of Radical Polymerization with an Ultrafast Coherent Raman Microscope

Author

Li, Haozheng, primary, Cheng, Yong, additional, Tang, Huajun, additional, Bi, Yali, additional, Chen, Yage, additional, Yang, Guang, additional, Guo, Shoujing, additional, Tian, Sidan, additional, Liao, Jiangshan, additional, Lv, Xiaohua, additional, Zeng, Shaoqun, additional, Zhu, Mingqiang, additional, Xu, Chenjie, additional, Cheng, Ji‐Xin, additional, and Wang, Ping, additional

Published
2020
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26. A Dual‐Functional Photosensitizer for Ultraefficient Photodynamic Therapy and Synchronous Anticancer Efficacy Monitoring

Author

Gao, Yuting, Wang, Xiuxia, He, Xuewen, He, Zhenyan, Yang, Xiang, Tian, Sidan, Meng, Fanling, Ding, Dan, Luo, Liang, Tang, Benzhong, Gao, Yuting, Wang, Xiuxia, He, Xuewen, He, Zhenyan, Yang, Xiang, Tian, Sidan, Meng, Fanling, Ding, Dan, Luo, Liang, and Tang, Benzhong

Abstract

A dual-functional photosensitizer that demonstrates exceptional photodynamic therapy (PDT) efficacy while simultaneously self-monitoring the therapeutic response in real time is reported here. Possessing an ultrahigh 1O2 quantum yield of 98.6% in water, the photosensitizer TPCI can efficiently induce cell death in a series of carcinoma cells (IC50 values less than 300 × 10−9 m) upon irradiation with an extremely low fluence (460 nm, 4 mW cm−2 for 10 min). In addition, TPCI can self-monitor cell death in real time. It is weakly fluorescent in living cells before irradiation and lights up the nuclei concomitantly with cell death during PDT treatment by binding with chromatin to activate its aggregation-induced emission, attributed to its strong binding affinity with DNA. In vivo studies using mouse models bearing H22 and B16F10 tumor cells validate the ultraefficient PDT efficacy of TPCI as well as the precise real-time noninvasive readout of the tumor response from the beginning of cancer treatment. The dual-functional TPCI serves as an excellent candidate for single-agent photodynamic theranostics, and this work represents a new paradigm for the development of molecules with multiple intrinsic functions for future self-reporting medical applications.

Published
2019

32. pH-Regulated Reversible Transition Between Polyion Complexes (PIC) and Hydrogen-Bonding Complexes (HBC) with Tunable Aggregation-Induced Emission

Author

Tian, Sidan, Liu, Guhuan, Wang, Xiaorui, Wu, Tao, Yang, Jinxian, Ye, Xiaodong, Zhang, Guoying, Hu, Jinming, and Liu, Shiyong

Abstract

The mimicking of biological supramolecular interactions and their mutual transitions to fabricate intelligent artificial systems has been of increasing interest. Herein, we report the fabrication of supramolecular micellar nanoparticles consisting of quaternized poly(ethylene oxide)-b-poly(2-dimethylaminoethyl methacrylate) (PEO-b-PQDMA) and tetrakis(4-carboxylmethoxyphenyl)ethene (TPE-4COOH), which was capable of reversible transition between polyion complexes (PIC) and hydrogen bonding complexes (HBC) with tunable aggregation-induced emission (AIE) mediated by solution pH. At pH 8, TPE-4COOH chromophores can be directly dissolved in aqueous milieu without evident fluorescence emission. However, upon mixing with PEO-b-PQDMA, polyion complexes were formed by taking advantage of electrostatic interaction between carboxylate anions and quaternary ammonium cations and the most compact PIC micelles were achieved at the isoelectric point (i.e., [QDMA+]/[COO–] = 1), as confirmed by dynamic light scattering (DLS) measurement. Simultaneously, fluorescence spectroscopy revealed an evident emission turn-on and the maximum fluorescence intensity was observed near the isoelectric point due to the restriction of intramolecular rotation of TPE moieties within the PIC cores. The kinetic study supported a micelle fusion/fission mechanism on the formation of PIC micelles at varying charge ratios, exhibiting a quick time constant (τ1) relating to the formation of quasi-equilibrium micelles and a slow time constant (τ2) corresponding to the formation of final equilibrium micelles. Upon deceasing the pH of PIC micelles from 8 to 2 at the [QDMA+]/[COO–] molar ratio of 1, TPE-4COOH chromophores became gradually protonated and hydrophobic. The size of micellar nanoparticles underwent a remarkable decrease, whereas the fluorescence intensity exhibited a further increase by approximately 7.35-fold, presumably because of the formation of HBC micelles comprising cationic PQDMA coronas and PEO/TPE-4COOH hydrogen-bonded cores, an inverted micellar structures compared to initial PIC micelles. Moreover, the pH-mediated schizophrenic micellar transition from PIC to HBC with tunable AIE characteristic was reversible.

Published
2016
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