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354 results on '"Tian, Jianbo"'

1. An atlas of genetic effects on cellular composition of the tumor microenvironment

Author

Cai, Yimin, Lu, Zequn, Chen, Can, Zhu, Ying, Chen, Zhirui, Wu, Zuyou, Peng, Jingyi, Zhu, Xuanyu, Liu, Ziying, Li, Bin, Zhang, Ming, Huang, Jinyu, Li, Yanmin, Liu, Yizhuo, Ma, Qianying, He, Chunyi, Chen, Shuoni, Tian, Wen, Fan, Linyun, Ning, Caibo, Geng, Hui, Xu, Bin, Li, Haijie, Zhu, Xu, Fang, Jun, Wang, Xiaoyang, Zhang, Shaokai, Jin, Meng, Huang, Chaoqun, Yang, Xiaojun, Tian, Jianbo, and Miao, Xiaoping

Published
2024
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3. Genetic architectures of the human hippocampus and those involved in neuropsychiatric traits

Author

Ning, Caibo, Jin, Meng, Cai, Yimin, Fan, Linyun, Hu, Kexin, Lu, Zequn, Zhang, Ming, Chen, Can, Li, Yanmin, Hu, Naifan, Zhang, Donghui, Liu, Yizhuo, Chen, Shuoni, Jiang, Yuan, He, Chunyi, Wang, Zhuo, Cao, Zilong, Li, Hanting, Li, Gaoyuan, Ma, Qianying, Geng, Hui, Tian, Wen, Zhang, Heng, Yang, Xiaojun, Huang, Chaoqun, Wei, Yongchang, Li, Bin, Zhu, Ying, Li, Xiangpan, Miao, Xiaoping, and Tian, Jianbo

Published
2024
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5. CHLORIDE DIFFUSION MODEL IN CORAL AGGREGATE CONCRETE UNDER EXTREMELY HOT AND HUMID MARINE ENVIRONMENTS

Author

Daguan Huang, Xiufei Li, Su Li, Tian Jianbo, and Zhao Zhanwei

Subjects
coral aggregate concrete, marine environment, multi-factor coupling effect, damage degree, chloride diffusion model, Clay industries. Ceramics. Glass, TP785-869
Abstract

In this paper, a chloride diffusion model of coral aggregate concrete under an extremely hot and humid marine environment was studied, and nine mix ratios of coral aggregate concrete were analysed and researched. Utilising Fick's second law, a chloride diffusion model for coral aggregate concrete was established. It considers the impact of the temperature, humidity, erosion time, compressive strength of coral aggregate concrete, fly ash content, and basalt fibre content on the chloride diffusion coefficient in the extremely hot and humid marine environment of the South China Sea. Furthermore, the impact of sulfate ions on the chloride diffusion was considered, and the degree of damage to the coral aggregate concrete was defined. A relationship between the relative chloride diffusion coefficient and the degree of concrete damage was established, thereby successfully incorporating sulfate erosion damage into the chloride diffusion model. Finally, an analysis was conducted on the values of the parameters in the diffusion model. The established chloride diffusion model was used to calculate the chloride concentration distribution under different erosion environments, and the experimental values were compared and analysed to verify the accuracy of the diffusion model. The results show that the calculated results are in good agreement with the experimental results. The establishment of the model can provide a theoretical basis for the durability design and life prediction of coral aggregate concrete under extremely hot and humid marine environments.

Published
2024
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8. Genome-wide association analysis of left ventricular imaging-derived phenotypes identifies 72 risk loci and yields genetic insights into hypertrophic cardiomyopathy

Author

Ning, Caibo, Fan, Linyun, Jin, Meng, Wang, Wenji, Hu, Zhiqiang, Cai, Yimin, Chen, Liangkai, Lu, Zequn, Zhang, Ming, Chen, Can, Li, Yanmin, Zhang, Fuwei, Wang, Wenzhuo, Liu, Yizhuo, Chen, Shuoni, Jiang, Yuan, He, Chunyi, Wang, Zhuo, Chen, Xu, Li, Hanting, Li, Gaoyuan, Ma, Qianying, Geng, Hui, Tian, Wen, Zhang, Heng, Liu, Bo, Xia, Qing, Yang, Xiaojun, Liu, Zhongchun, Li, Bin, Zhu, Ying, Li, Xiangpan, Zhang, Shaoting, Tian, Jianbo, and Miao, Xiaoping

Published
2023
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9. Genome-wide enhancer-gene regulatory maps link causal variants to target genes underlying human cancer risk

Author

Ying, Pingting, Chen, Can, Lu, Zequn, Chen, Shuoni, Zhang, Ming, Cai, Yimin, Zhang, Fuwei, Huang, Jinyu, Fan, Linyun, Ning, Caibo, Li, Yanmin, Wang, Wenzhuo, Geng, Hui, Liu, Yizhuo, Tian, Wen, Yang, Zhiyong, Liu, Jiuyang, Huang, Chaoqun, Yang, Xiaojun, Xu, Bin, Li, Heng, Zhu, Xu, Li, Ni, Li, Bin, Wei, Yongchang, Zhu, Ying, Tian, Jianbo, and Miao, Xiaoping

Published
2023
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11. HSPA12A was identified as a key driver in colorectal cancer GWAS loci 10q26.12 and modulated by an enhancer–promoter interaction

Author

Lu, Zequn, Fan, Linyun, Zhang, Fuwei, Huang, Chaoqun, Cai, Yimin, Chen, Can, Li, Gaoyuan, Zhang, Ming, Huang, Jinyu, Ning, Caibo, Li, Yanmin, Wang, Wenzhuo, Geng, Hui, Liu, Yizhuo, Chen, Shuoni, Li, Hanting, Yang, Shuhui, Zhang, Heng, Tian, Wen, Ye, Tianrun, Liu, Jiuyang, Yang, Xiaojun, Xu, Bin, Zhu, Ying, Zhong, Rong, Li, Heng, Tian, Jianbo, Li, Bin, and Miao, Xiaoping

Published
2023
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16. Genetic Control of Alternative Splicing and its Distinct Role in Colorectal Cancer Mechanisms

Author

Zhang, Ming, Chen, Can, Lu, Zequn, Cai, Yimin, Li, Yanmin, Zhang, Fuwei, Liu, Yizhuo, Chen, Shuoni, Zhang, Heng, Yang, Shuhui, Gen, Hui, Jiang, Yuan, Ning, Caibo, Huang, Jinyu, Wang, Wenzhuo, Fan, Linyun, Zhang, Yi, Jin, Meng, Han, Jinxin, Xiong, Zhen, Cai, Ming, Liu, Jiuyang, Huang, Chaoqun, Yang, Xiaojun, Xu, Bin, Li, Heng, Li, Bin, Zhu, Xu, Wei, Yongchang, Zhu, Ying, Tian, Jianbo, and Miao, Xiaoping

Published
2023
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19. Comparison of Colonoscopy, Fecal Immunochemical Test, and Risk-Adapted Approach in a Colorectal Cancer Screening Trial (TARGET-C)

Author

Chen, Hongda, Shi, Jufang, Lu, Ming, Li, Yanjie, Du, Lingbin, Liao, Xianzhen, Wei, Donghua, Dong, Dong, Gao, Yi, Zhu, Chen, Ying, Rongbiao, Zheng, Weifang, Yan, Shipeng, Xiao, Haifan, Zhang, Juan, Kong, Yunxin, Li, Furong, Zou, Shuangmei, Liu, Chengcheng, Wang, Hong, Zhang, Yuhan, Lu, Bin, Luo, Chenyu, Cai, Jie, Tian, Jianbo, Miao, Xiaoping, Ding, Kefeng, Brenner, Hermann, and Dai, Min

Published
2023
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28. Clinical characteristics and risk factors associated with COVID-19 disease severity in patients with cancer in Wuhan, China: a multicentre, retrospective, cohort study

Author

Tian, Jianbo, Yuan, Xianglin, Xiao, Jun, Zhong, Qiang, Yang, Chunguang, Liu, Bo, Cai, Yimin, Lu, Zequn, Wang, Jing, Wang, Yanan, Liu, Shuanglin, Cheng, Biao, Wang, Jin, Zhang, Ming, Wang, Lu, Niu, Siyuan, Yao, Zhi, Deng, Xiongbo, Zhou, Fan, Wei, Wei, Li, Qinglin, Chen, Xin, Chen, Wenqiong, Yang, Qin, Wu, Shiji, Fan, Jiquan, Shu, Bo, Hu, Zhiquan, Wang, Shaogang, Yang, Xiang-Ping, Liu, Wenhua, Miao, Xiaoping, and Wang, Zhihua

Published
2020
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31. Data from Genetic Variants That Impact Alternative Polyadenylation in Cancer Represent Candidate Causal Risk Loci

Author

Li, Bin, primary, Cai, Yimin, primary, Chen, Can, primary, Li, Gaoyuan, primary, Zhang, Ming, primary, Lu, Zequn, primary, Zhang, Fuwei, primary, Huang, Jinyu, primary, Fan, Linyun, primary, Ning, Caibo, primary, Li, Yanmin, primary, Wang, Wenzhuo, primary, Geng, Hui, primary, Liu, Yizhuo, primary, Chen, Shuoni, primary, Li, Hanting, primary, Yang, Shuhui, primary, Zhang, Heng, primary, Tian, Wen, primary, Zhu, Zhongchao, primary, Xu, Bin, primary, Li, Heng, primary, Li, Haijie, primary, Jin, Meng, primary, Wang, Xiaoyang, primary, Zhang, Shaokai, primary, Liu, Jiuyang, primary, Huang, Chaoqun, primary, Yang, Xiaojun, primary, Wei, Yongchang, primary, Zhu, Ying, primary, Tian, Jianbo, primary, and Miao, Xiaoping, primary

Published
2023
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32. Supplementary Data from Genetic Variants That Impact Alternative Polyadenylation in Cancer Represent Candidate Causal Risk Loci

Author

Li, Bin, primary, Cai, Yimin, primary, Chen, Can, primary, Li, Gaoyuan, primary, Zhang, Ming, primary, Lu, Zequn, primary, Zhang, Fuwei, primary, Huang, Jinyu, primary, Fan, Linyun, primary, Ning, Caibo, primary, Li, Yanmin, primary, Wang, Wenzhuo, primary, Geng, Hui, primary, Liu, Yizhuo, primary, Chen, Shuoni, primary, Li, Hanting, primary, Yang, Shuhui, primary, Zhang, Heng, primary, Tian, Wen, primary, Zhu, Zhongchao, primary, Xu, Bin, primary, Li, Heng, primary, Li, Haijie, primary, Jin, Meng, primary, Wang, Xiaoyang, primary, Zhang, Shaokai, primary, Liu, Jiuyang, primary, Huang, Chaoqun, primary, Yang, Xiaojun, primary, Wei, Yongchang, primary, Zhu, Ying, primary, Tian, Jianbo, primary, and Miao, Xiaoping, primary

Published
2023
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33. Clinical characteristics and risk factors of fatal patients with COVID-19: a retrospective cohort study in Wuhan, China

Author

Jin, Meng, Lu, Zequn, Zhang, Xu, Wang, Yanan, Wang, Jing, Cai, Yimin, Tian, Kunming, Xiong, Zezhong, Zhong, Qiang, Ran, Xiao, Yang, Chunguang, Zeng, Xing, Wang, Lu, Li, Yao, Zhang, Shanshan, Dong, Tianyi, Yue, Xinying, Li, Heng, Liu, Bo, Chen, Xin, Cui, Hongyuan, Qi, Jirong, Fan, Haining, Li, Haixia, Yang, Xiang-Ping, Hu, Zhiquan, Wang, Shaogang, Xiao, Jun, Wang, Ying, Tian, Jianbo, and Wang, Zhihua

Published
2021
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40. Genetic variants that impact alternative polyadenylation in cancer represent candidate causal risk loci

Author

Li, Bin, primary, Cai, Yimin, additional, Chen, Can, additional, Li, Gaoyuan, additional, Zhang, Ming, additional, Lu, Zequn, additional, Zhang, Fuwei, additional, Huang, Jinyu, additional, Fan, Linyun, additional, Ning, Caibo, additional, Li, Yanmin, additional, Wang, Wenzhuo, additional, Geng, Hui, additional, Liu, Yizhuo, additional, Chen, Shuoni, additional, Li, Hanting, additional, Yang, Shuhui, additional, Zhang, Heng, additional, Tian, Wen, additional, Zhu, Zhongchao, additional, Xu, Bin, additional, Li, Heng, additional, Li, Haijie, additional, Jin, Meng, additional, Wang, Xiaoyang, additional, Zhang, Shaokai, additional, Liu, Jiuyang, additional, Huang, Chaoqun, additional, Yang, Xiaojun, additional, Wei, Yongchang, additional, Zhu, Ying, additional, Tian, Jianbo, additional, and Miao, Xiaoping, additional

Published
2023
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43. Birthweight, genetic risk, and gastrointestinal cancer incidence: a prospective cohort study

Author

Long, Lu, He, Heng, Shen, Qian, Peng, Hongxia, Zhou, Xiaorui, Wang, Haoxue, Zhang, Shanshan, Qin, Shifan, Lu, Zequn, Zhu, Ying, Tian, Jianbo, Chang, Jiang, Miao, Xiaoping, Shen, Na, and Zhong, Rong

Subjects
Adult, Cohort Studies, Pancreatic Neoplasms, Risk Factors, Incidence, Humans, Birth Weight, Prospective Studies, General Medicine, Gastrointestinal Neoplasms
Abstract

The epidemiologic studies investigating the association of birthweight and genetic factors with gastrointestinal cancer remain scarce. The study aimed to prospectively assess the interactions and joint effects of birthweight and genetic risk levels on gastrointestinal cancer incidence in adulthood. A total of 254,997 participants were included in the UK Biobank study. We used multivariate restricted cubic splines and Cox regression models to estimate the hazard ratios (HRs) and 95% confidential intervals (CI) for the association between birthweight and gastrointestinal cancer risk, then constructed a polygenic risk score (PRS) to assess its interaction and joint effect with birthweight on the development of gastrointestinal cancer. We documented 2512 incident cases during a median follow-up of 8.88 years. Compare with participants reporting a normal birthweight (2.5–4.5 kg), multivariable-adjusted HR of gastrointestinal cancer incidence for participants with high birthweight (≥4.5 kg) was 1.17 (95%CI: 1.01–1.36). Such association was remarkably observed in pancreatic cancer, with an HR of 1.82 (95%CI: 1.26–2.64). No statistically significant association was observed between low birth weight and gastrointestinal cancers. Participants with high birthweight and high PRS had the highest risk of gastrointestinal cancer (HR: 2.95, 95%CI: 2.19–3.96). Our findings highlight that high birthweight is associated with a higher incidence of gastrointestinal cancer, especially for pancreatic cancer. Benefits would be obtained from birthweight control, particularly for individuals with a high genetic risk.KEY MESSAGESThe epidemiologic studies investigating the association of birthweight and genetic factors with gastrointestinal cancer remain scarce.This cohort study of 254,997 adults in the United Kingdom found an association of high birthweight with the incidence of gastrointestinal cancer, especially for pancreatic cancer, and also found that participants with high birthweight and high polygenic risk score had the highest risk of gastrointestinal cancer.Our data suggests a possible effect of in utero or early life exposures on adulthood gastrointestinal cancer, especially for those with a high genetic risk. The epidemiologic studies investigating the association of birthweight and genetic factors with gastrointestinal cancer remain scarce. This cohort study of 254,997 adults in the United Kingdom found an association of high birthweight with the incidence of gastrointestinal cancer, especially for pancreatic cancer, and also found that participants with high birthweight and high polygenic risk score had the highest risk of gastrointestinal cancer. Our data suggests a possible effect of in utero or early life exposures on adulthood gastrointestinal cancer, especially for those with a high genetic risk.

Published
2022

44. Supplementary Data from Genome-Wide Splicing Quantitative Expression Locus Analysis Identifies Causal Risk Variants for Non–Small Cell Lung Cancer

Author

Jin, Meng, primary, Liu, Bo, primary, Chen, Can, primary, Huang, Yongbiao, primary, Zhang, Huixian, primary, Chen, Bingliang, primary, Song, Guoda, primary, Zhao, Dong, primary, Duan, Limin, primary, Liu, Wei, primary, Yang, Haizhen, primary, Yue, Fang, primary, Liu, Peijun, primary, Yuan, Xianglin, primary, Chu, Qian, primary, Tian, Jianbo, primary, and Hu, Ke, primary

Published
2023
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45. Data from Genome-Wide Splicing Quantitative Expression Locus Analysis Identifies Causal Risk Variants for Non–Small Cell Lung Cancer

Author

Jin, Meng, primary, Liu, Bo, primary, Chen, Can, primary, Huang, Yongbiao, primary, Zhang, Huixian, primary, Chen, Bingliang, primary, Song, Guoda, primary, Zhao, Dong, primary, Duan, Limin, primary, Liu, Wei, primary, Yang, Haizhen, primary, Yue, Fang, primary, Liu, Peijun, primary, Yuan, Xianglin, primary, Chu, Qian, primary, Tian, Jianbo, primary, and Hu, Ke, primary

Published
2023
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46. Triclosan is associated with breast cancer via oxidative stress and relative telomere length

Author

Cai, Xiaomin, primary, Ning, Caibo, additional, Fan, Linyun, additional, Li, Yanmin, additional, Wang, Lu, additional, He, Heng, additional, Dong, Tianyi, additional, Cai, Yimin, additional, Zhang, Ming, additional, Lu, Zequn, additional, Chen, Can, additional, Shi, Ke, additional, Ye, Tianrun, additional, Zhong, Rong, additional, Tian, Jianbo, additional, Li, Heng, additional, Li, Haijie, additional, Zhu, Ying, additional, and Miao, Xiaoping, additional

Published
2023
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50. Birthweight, genetic risk, and gastrointestinal cancer incidence: a prospective cohort study.

Author

Long, Lu, He, Heng, Shen, Qian, Peng, Hongxia, Zhou, Xiaorui, Wang, Haoxue, Zhang, Shanshan, Qin, Shifan, Lu, Zequn, Zhu, Ying, Tian, Jianbo, Chang, Jiang, Miao, Xiaoping, Shen, Na, and Zhong, Rong

Subjects
GASTROINTESTINAL cancer, WEIGHT in infancy, BIRTH weight, LOW birth weight, DISEASE risk factors, PANCREATIC cancer
Abstract

The epidemiologic studies investigating the association of birthweight and genetic factors with gastrointestinal cancer remain scarce. The study aimed to prospectively assess the interactions and joint effects of birthweight and genetic risk levels on gastrointestinal cancer incidence in adulthood. A total of 254,997 participants were included in the UK Biobank study. We used multivariate restricted cubic splines and Cox regression models to estimate the hazard ratios (HRs) and 95% confidential intervals (CI) for the association between birthweight and gastrointestinal cancer risk, then constructed a polygenic risk score (PRS) to assess its interaction and joint effect with birthweight on the development of gastrointestinal cancer. We documented 2512 incident cases during a median follow-up of 8.88 years. Compare with participants reporting a normal birthweight (2.5–4.5 kg), multivariable-adjusted HR of gastrointestinal cancer incidence for participants with high birthweight (≥4.5 kg) was 1.17 (95%CI: 1.01–1.36). Such association was remarkably observed in pancreatic cancer, with an HR of 1.82 (95%CI: 1.26–2.64). No statistically significant association was observed between low birth weight and gastrointestinal cancers. Participants with high birthweight and high PRS had the highest risk of gastrointestinal cancer (HR: 2.95, 95%CI: 2.19–3.96). Our findings highlight that high birthweight is associated with a higher incidence of gastrointestinal cancer, especially for pancreatic cancer. Benefits would be obtained from birthweight control, particularly for individuals with a high genetic risk. The epidemiologic studies investigating the association of birthweight and genetic factors with gastrointestinal cancer remain scarce. This cohort study of 254,997 adults in the United Kingdom found an association of high birthweight with the incidence of gastrointestinal cancer, especially for pancreatic cancer, and also found that participants with high birthweight and high polygenic risk score had the highest risk of gastrointestinal cancer. Our data suggests a possible effect of in utero or early life exposures on adulthood gastrointestinal cancer, especially for those with a high genetic risk. [ABSTRACT FROM AUTHOR]

Published
2023
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