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2,869 results on '"Thyssen, Jacob P"'

1. Psoriasis localization patterns in the Swiss Psoriasis Registry (SDNTT) over 11 years: an analysis by sex and age

Author

Birkenmaier, Ion, Maul, Lara Valeska, Oyanguren, Iker, Sorbe, Christina, Fröhlich, Fabienne, Schlapbach, Christoph, Heidemeyer, Kristine, Yawalkar, Nikhil, Boehncke, Wolf-Henning, Ring, Hans-Christian, Thyssen, Jacob P., Egeberg, Alexander, Micheroli, Raphael, Thomsen, Simon Francis, Mainetti, Carlo, Cozzio, Antonio, Kündig, Thomas M., Levesque, Mitchell P., Navarini, Alexander, and Maul, Julia-Tatjana

Published
2024
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2. Diagnosis and Management of Pediatric Chronic Hand Eczema: The PeDRA CACHES Survey

Author

Haft, Michael A, Park, Helen H, Lee, Stephanie S, Sprague, Jessica M, Paller, Amy S, Cotton, Colleen H, Thyssen, Jacob P, and Eichenfield, Lawrence F

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Skin, Humans, Child, United States, Dermatology, Prospective Studies, Quality of Life, Eczema, Dermatitis, Atopic, Paediatrics and Reproductive Medicine, Pharmacology and Pharmaceutical Sciences, Pediatrics, Paediatrics, Pharmacology and pharmaceutical sciences
Abstract

BackgroundChronic hand eczema (CHE) significantly impacts quality of life. Published literature on pediatric CHE (P-CHE) in North America including knowledge on epidemiology and standard evaluation and management is limited.ObjectiveOur objective was to assess diagnostic practices when evaluating patients with P-CHE in the US and Canada, produce data on therapeutic agent prescribing practices for the disorder, and lay the foundation for future studies.MethodsWe surveyed pediatric dermatologists to collect data on clinician and patient population demographics, diagnostic methods, therapeutic agent selection, among other statistics. From June 2021 to January 2022, a survey was distributed to members of the Pediatric Dermatology Research Alliance (PeDRA).ResultsFifty PeDRA members responded stating that they would be interested in participating, and 21 surveys were completed. For patients with P-CHE, providers most often utilize the diagnoses of irritant contact dermatitis, allergic contact dermatitis, dyshidrotic hand eczema, and atopic dermatitis. Contact allergy patch testing and bacterial hand culture are the most used tests for workup. Nearly all utilize topical corticosteroids as first line therapy. Most responders report that they have treated fewer than six patients with systemic agents and prefer dupilumab as first-line systemic therapy.ConclusionsThis is the first characterization of P-CHE among pediatric dermatologists in the United States and Canada. This assessment may prove useful in designing further investigations including prospective studies of P-CHE epidemiology, morphology, nomenclature, and management.

Published
2023

4. The Validated Investigator Global Assessment for Atopic Dermatitis (vIGA‐AD™): a clinical outcome measure for the severity of atopic dermatitis

Author

Simpson, Eric L, Bissonnette, Robert, Paller, Amy S, King, Brett, Silverberg, Jonathan I, Reich, Kristian, Thyssen, Jacob P, Doll, Helen, Sun, Luna, DeLozier, Amy M, Nunes, Fabio P, and Eichenfield, Lawrence F

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Adult, Azetidines, Clinical Trials, Phase III as Topic, Dermatitis, Atopic, Humans, Outcome Assessment, Health Care, Purines, Pyrazoles, Reproducibility of Results, Severity of Illness Index, Sulfonamides, Oncology and Carcinogenesis, Dermatology & Venereal Diseases, Clinical sciences
Abstract

BackgroundThe validated Investigator Global Assessment for Atopic Dermatitis (vIGA-AD™) is a standardized severity assessment for use in clinical trials and registries for atopic dermatitis (AD).ObjectivesTo investigate the reliability, validity, responsiveness and within-patient meaningful change of the vIGA-AD.MethodsData were analysed from adult patients with moderate-to-severe AD in the BREEZE-AD1 (N = 624 patients; NCT03334396), BREEZE-AD2 (N = 615; NCT03334422) and BREEZE-AD5 (N = 440; NCT03435081) phase III baricitinib clinical studies.ResultsAcross studies, test-retest reliability for stable patients showed moderate-to-good agreement [range of Kappa values for Patient Global Impression of Severity-Atopic Dermatitis (PGI-S-AD), 0·516-0·639; for Eczema Area and Severity Index (EASI), 0·658-0·778]. Moderate-to-large correlations between vIGA-AD and EASI or body surface area (range at baseline, 0·497-0·736; Week 16, 0·716-0·893) supported convergent validity. Known-groups validity was demonstrated vs. EASI and PGI-S-AD (vIGA-AD for severe vs. moderate EASI categories at baseline, P

Published
2022

12. European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation

Author

Budu-Aggrey, Ashley, Kilanowski, Anna, Sobczyk, Maria K., Shringarpure, Suyash S., Mitchell, Ruth, Reis, Kadri, Reigo, Anu, Mägi, Reedik, Nelis, Mari, Tanaka, Nao, Brumpton, Ben M., Thomas, Laurent F., Sole-Navais, Pol, Flatley, Christopher, Espuela-Ortiz, Antonio, Herrera-Luis, Esther, Lominchar, Jesus V. T., Bork-Jensen, Jette, Marenholz, Ingo, Arnau-Soler, Aleix, Jeong, Ayoung, Fawcett, Katherine A., Baurecht, Hansjorg, Rodriguez, Elke, Alves, Alexessander Couto, Kumar, Ashish, Sleiman, Patrick M., Chang, Xiao, Medina-Gomez, Carolina, Hu, Chen, Xu, Cheng-jian, Qi, Cancan, El-Heis, Sarah, Titcombe, Philip, Antoun, Elie, Fadista, João, Wang, Carol A., Thiering, Elisabeth, Wu, Baojun, Kress, Sara, Kothalawala, Dilini M., Kadalayil, Latha, Duan, Jiasong, Zhang, Hongmei, Hadebe, Sabelo, Hoffmann, Thomas, Jorgenson, Eric, Choquet, Hélène, Risch, Neil, Njølstad, Pål, Andreassen, Ole A., Johansson, Stefan, Almqvist, Catarina, Gong, Tong, Ullemar, Vilhelmina, Karlsson, Robert, Magnusson, Patrik K. E., Szwajda, Agnieszka, Burchard, Esteban G., Thyssen, Jacob P., Hansen, Torben, Kårhus, Line L., Dantoft, Thomas M., Jeanrenaud, Alexander C.S.N., Ghauri, Ahla, Arnold, Andreas, Homuth, Georg, Lau, Susanne, Nöthen, Markus M., Hübner, Norbert, Imboden, Medea, Visconti, Alessia, Falchi, Mario, Bataille, Veronique, Hysi, Pirro, Ballardini, Natalia, Boomsma, Dorret I., Hottenga, Jouke J., Müller-Nurasyid, Martina, Ahluwalia, Tarunveer S., Stokholm, Jakob, Chawes, Bo, Schoos, Ann-Marie M., Esplugues, Ana, Bustamante, Mariona, Raby, Benjamin, Arshad, Syed, German, Chris, Esko, Tõnu, Milani, Lili A., Metspalu, Andres, Terao, Chikashi, Abuabara, Katrina, Løset, Mari, Hveem, Kristian, Jacobsson, Bo, Pino-Yanes, Maria, Strachan, David P., Grarup, Niels, Linneberg, Allan, Lee, Young-Ae, Probst-Hensch, Nicole, Weidinger, Stephan, Jarvelin, Marjo-Riitta, Melén, Erik, Hakonarson, Hakon, Irvine, Alan D., Jarvis, Deborah, Nijsten, Tamar, Duijts, Liesbeth, Vonk, Judith M., Koppelmann, Gerard H., Godfrey, Keith M., Barton, Sheila J., Feenstra, Bjarke, Pennell, Craig E., Sly, Peter D., Holt, Patrick G., Williams, L. Keoki, Bisgaard, Hans, Bønnelykke, Klaus, Curtin, John, Simpson, Angela, Murray, Clare, Schikowski, Tamara, Bunyavanich, Supinda, Weiss, Scott T., Holloway, John W., Min, Josine L., Brown, Sara J., Standl, Marie, and Paternoster, Lavinia

Published
2023
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18. Psychometric properties of the itch numeric rating scale, skin pain numeric rating scale, and atopic dermatitis sleep scale in adult patients with moderate-to-severe atopic dermatitis

Author

Silverberg, Jonathan I, DeLozier, Amy, Sun, Luna, Thyssen, Jacob P, Kim, Brian, Yosipovitch, Gil, Nunes, Fabio P, Gugiu, P Cristian, Doll, Helen A, and Eichenfield, Lawrence F

Subjects
Health Services and Systems, Public Health, Health Sciences, Pain Research, Neurosciences, Clinical Research, Chronic Pain, Adult, Dermatitis, Atopic, Humans, Pain, Psychometrics, Quality of Life, Reproducibility of Results, Severity of Illness Index, Sleep, Atopic dermatitis, Atopic dermatitis sleep scale, Convergent-divergent validity, Itch NRS, Numeric rating scale, Patient-reported outcome, Psychometric, Reliability, Responsiveness, Skin pain NRS, Validity, Public Health and Health Services, Health Policy & Services, Health services and systems, Public health
Abstract

BackgroundThe Itch Numeric Rating Scale (NRS), Skin Pain NRS, and Atopic Dermatitis Sleep Scale (ADSS) are self-administered patient-reported outcome (PRO) instruments developed to assess symptoms in patients with atopic dermatitis (AD). The objective of this study was to evaluate the psychometric properties (reliability, validity, and responsiveness) and interpretability thresholds of these PROs using data from three pivotal Phase 3 studies in adults.MethodsBREEZE-AD1, BREEZE-AD2, and BREEZE-AD5 evaluated the safety and efficacy of baricitinib in adults with moderate-to-severe AD. Clinician-reported outcomes and other PROs commonly assessed in patients with AD were used to estimate meaningful changes and evaluate test-retest reliability, convergent and divergent validity, known-groups validity, responsiveness, and meaningful change thresholds (MCTs) of the Itch NRS, Skin Pain NRS, and ADSS.ResultsThe test-retest reliability of the Itch NRS, Skin Pain NRS, and ADSS was evidenced by generally large intraclass correlation coefficients (> 0.7) in stable groups of patients between baseline and Week 1 and Weeks 4 and 8. Moderate-to-large correlations (r > 0.4) at baseline and Week 16 were generally observed between each measure and other PROs measuring the same concept, supporting convergent validity. Small-to-moderate correlations with clinician-reported outcomes demonstrated divergent validity. Each instrument was able to distinguish between known groups of disease severity as assessed using other indicators of AD severity. The responsiveness of the Itch NRS, Skin Pain NRS, and ADSS scales was demonstrated through significant differences in their change scores from baseline to Week 16 between categories of change in another PRO also from baseline to Week 16. Thresholds for interpreting meaningful change were estimated as - 4.0 for the 0-10 Itch and Skin Pain NRS items; - 1.25 for the 0-4 ADSS Items 1 and 3 and; - 1.50 for the 0-29 ADSS Item 2, these equivalent to moderate degrees of change.ConclusionsResults of this study demonstrate that the psychometric properties of the Itch NRS, Skin Pain NRS, and ADSS are good to excellent. These findings support the use of these instruments in daily assessment of AD symptoms in adults with moderate-to-severe AD. Trial registration ClinicalTrials.gov numbers: NCT03334396, NCT03334422, and NCT03435081.

Published
2021

23. Reduced Skin Microbiome Diversity in Infancy Is Associated with Increased Risk of Atopic Dermatitis in High-Risk Children

Author

Halling, Anne-Sofie, Fritz, Blaine Gabriel, Gerner, Trine, Rinnov, Maria Rasmussen, Bay, Lene, Knudgaard, Mette Hjorslev, Ravn, Nina Haarup, Trautner, Simon, Ruge, Iben Frier, Olesen, Caroline, Díiaz-Pinées Cort, Isabel, Skov, Lone, Sørensen, Nikolaj, Møller Rønnstad, Amalie Thorsti, Thomsen, Simon F., Egeberg, Alexander, Jakasa, Ivone, Kezic, Sanja, Bjarnsholt, Thomas, and Thyssen, Jacob P.

Published
2023
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27. Drug survival of biologics and novel immunomodulators for rheumatoid arthritis, axial spondyloarthritis, psoriatic arthritis, and psoriasis - A nationwide cohort study from the DANBIO and DERMBIO registries

Author

Egeberg, Alexander, Rosenø, Nana Aviaaja Lippert, Thein, David, Lørup, Erik Hillo, Nielsen, Mia-Louise, Nymand, Lea, Kristensen, Lars Erik, Thyssen, Jacob P., Thomsen, Simon Francis, Cordtz, Rene Lindholm, Loft, Nikolai, Skov, Lone, Bryld, Lars Erik, Rasmussen, Mads Kirchheiner, Højgaard, Pil, Kristensen, Salome, and Dreyer, Lene

Published
2022
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29. Contact Allergy to Metals

Author

Thyssen, Jacob P., Ahlström, Malin G., Bruze, Magnus, Rustemeyer, Thomas, Lidén, Carola, Johansen, Jeanne Duus, editor, Mahler, Vera, editor, Lepoittevin, Jean-Pierre, editor, and Frosch, Peter J., editor

Published
2021
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36. RNA‐sequencing of paired tape‐strips and skin biopsies in atopic dermatitis reveals key differences

Author

Fritz, Blaine, primary, Halling, Anne‐Sofie, additional, Cort, Isabel Díaz‐Pinés, additional, Christensen, Maria Oberländer, additional, Rønnstad, Amalie Thorsti Møller, additional, Olesen, Caroline Meyer, additional, Knudgaard, Mette Hjorslev, additional, Zachariae, Claus, additional, Heegaard, Steffen, additional, Thyssen, Jacob P., additional, and Bjarnsholt, Thomas, additional

Published
2024
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37. Correlation between Dermatology Life Quality Index and Psoriasis Area and Severity Index in Patients with Psoriasis: A Cross-sectional Global Healthcare Study on Psoriasis

Author

Maul, Julia-Tatjana, primary, Maul, Lara W., additional, Didaskalu, Johannes A., additional, Valenzuela, Fernando, additional, Romiti, Ricardo, additional, Peterson, Hannah, additional, Korouri, Edwin, additional, Novoa, Farah, additional, Oon, Hazel H., additional, Zheng, Min, additional, Wu, Jashin J., additional, Thyssen, Jacob P., additional, Egeberg, Alexander, additional, Armstrong, April W., additional, and Nielsen, Mia-Louise, additional

Published
2024
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