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174 results on '"Thymine DNA Glycosylase metabolism"'

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1. Thymine DNA glycosylase combines sliding, hopping, and nucleosome interactions to efficiently search for 5-formylcytosine.

2. Enhanced thermal stability enables human mismatch-specific thymine-DNA glycosylase to catalyse futile DNA repair.

3. DCAF2 regulates the proliferation and differentiation of mouse progenitor spermatogonia by targeting p21 and thymine DNA glycosylase.

4. Glycosylase-based base editors for efficient T-to-G and C-to-G editing in mammalian cells.

5. Theoretical Insights into N-Glycoside Bond Cleavage of 5-Carboxycytosine by Thymine DNA Glycosylase: A QM/MM Study.

6. Analysis of the Model of Atherosclerosis Formation in Pig Hearts as a Result of Impaired Activity of DNA Repair Enzymes.

7. Chimeric d/l-DNA Probes of Base Excision Repair Enable Real-Time Monitoring of Thymine DNA Glycosylase Activity in Live Cells.

8. Thymine DNA glycosylase regulates cell-cycle-driven p53 transcriptional control in pluripotent cells.

9. Thymine DNA glycosylase mediates chromatin phase separation in a DNA methylation-dependent manner.

10. Comprehensive analysis of the prognostic value and biological function of TDG in hepatocellular carcinoma.

11. Thymine DNA glycosylase is an RNA-binding protein with high selectivity for G-rich sequences.

12. Rapid excision of oxidized adenine by human thymine DNA glycosylase.

13. Chemical and enzymatic modifications of 5-methylcytosine at the intersection of DNA damage, repair, and epigenetic reprogramming.

14. Computational investigations on target-site searching and recognition mechanisms by thymine DNA glycosylase during DNA repair process.

15. Kinetic Analysis of the Effect of N -Terminal Acetylation on Thymine DNA Glycosylase.

16. Kinetics and thermodynamics of BI-BII interconversion altered by T:G mismatches in DNA.

17. TDG suppresses the migration and invasion of human colon cancer cells via the DNMT3A/TIMP2 axis.

18. Measurement of deaminated cytosine adducts in DNA using a novel hybrid thymine DNA glycosylase.

19. TDG is a pig-specific epigenetic regulator with insensitivity to H3K9 and H3K27 demethylation in nuclear transfer embryos.

20. Direct and Base Excision Repair-Mediated Regulation of a GC-Rich cis -Element in Response to 5-Formylcytosine and 5-Carboxycytosine.

21. Interaction of Thymine DNA Glycosylase with Oxidised 5-Methyl-cytosines in Their Amino- and Imino-Forms.

22. TET-TDG Active DNA Demethylation at CpG and Non-CpG Sites.

23. Reversible chromatin condensation by the DNA repair and demethylation factor thymine DNA glycosylase.

24. Atomic resolution of short-range sliding dynamics of thymine DNA glycosylase along DNA minor-groove for lesion recognition.

25. The Effect of Allopregnanolone on Enzymatic Activity of the DNA Base Excision Repair Pathway in the Sheep Hippocampus and Amygdala under Natural and Stressful Conditions.

26. Inducible TDG knockout models to study epigenetic regulation.

27. Inducible TDG knockout models to study epigenetic regulation.

28. Key structural motifs in Thymine DNA glycosylase responsible for recognizing certain DNA bent conformation revealed by atomic simulations.

29. Catalytic mechanism of the mismatch-specific DNA glycosylase methyl-CpG-binding domain 4.

30. Loss of Thymine DNA Glycosylase Causes Dysregulation of Bile Acid Homeostasis and Hepatocellular Carcinoma.

31. Excision of 5-Carboxylcytosine by Thymine DNA Glycosylase.

32. Thymine DNA glycosylase is a key regulator of CaMKIIγ expression and vascular smooth muscle phenotype.

33. Chromatin Structure and the Pioneering Transcription Factor FOXA1 Regulate TDG-Mediated Removal of 5-Formylcytosine from DNA.

34. Synthesis of 5-Dihydroxyboryluridine Phosphoramidite and Its Site-Specific Incorporation into Oligonucleotides for Probing Thymine DNA Glycosylase.

35. Label-free and amplified electrogenerated chemiluminescence biosensing for the detection of thymine DNA glycosylase activity using DNA-functionalized gold nanoparticles triggered hybridization chain reaction.

36. Thymine DNA glycosylase as a novel target for melanoma.

37. Mutations in the DNMT3A DNA methyltransferase in acute myeloid leukemia patients cause both loss and gain of function and differential regulation by protein partners.

38. Nucleosomes and the three glycosylases: High, medium, and low levels of excision by the uracil DNA glycosylase superfamily.

39. [Role of MBD4 in hypermutator phenotype and malignant transformation].

40. Interactions of the DNA Repair Enzyme Human Thymine DNA Glycosylase with Cognate and Noncognate DNA.

41. Base-flipping dynamics from an intrahelical to an extrahelical state exerted by thymine DNA glycosylase during DNA repair process.

42. Uncovering universal rules governing the selectivity of the archetypal DNA glycosylase TDG.

43. Defining the impact of sumoylation on substrate binding and catalysis by thymine DNA glycosylase.

44. Dynamics of the excised base release in thymine DNA glycosylase during DNA repair process.

45. Stable Oxidative Cytosine Modifications Accumulate in Cardiac Mesenchymal Cells From Type2 Diabetes Patients: Rescue by α-Ketoglutarate and TET-TDG Functional Reactivation.

46. Functional impacts of 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxycytosine at a single hemi-modified CpG dinucleotide in a gene promoter.

47. TET2- and TDG-mediated changes are required for the acquisition of distinct histone modifications in divergent terminal differentiation of myeloid cells.

48. Nei-like 1 (NEIL1) excises 5-carboxylcytosine directly and stimulates TDG-mediated 5-formyl and 5-carboxylcytosine excision.

49. Combinatorial DNA methylation codes at repetitive elements.

50. Regulation of Active DNA Demethylation through RAR-Mediated Recruitment of a TET/TDG Complex.

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