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1. Spatial Analysis of Drug-Susceptible and Multidrug-Resistant Cases of Tuberculosis, Ho Chi Minh City, Vietnam, 2020-2023

Author

Spies, Ruan, Hong, Hanh N., Trieu, Phu P., Lan, Luong K., Lan, Kim, Hue, N.N., Huong, Nguyen T.L., Thao, Tran T.L.N., Quang, Nguyen L., Anh, Thu D.D., Vinh, Truong V., Ha, Dang T.M., Dat, Phan T., Hai, Nguyen P., Van, Le H., Thwaites, Guy E., Thuong, Nguyen T.T., Watson, James A., and Walker, Timothy M.

Subjects
Ho Chi Minh City, Vietnam -- Health aspects, Tuberculosis -- Statistics -- Risk factors -- Distribution -- Demographic aspects, Company distribution practices, Health
Abstract

Tuberculosis (TB) causes more deaths worldwide than any other infectious disease. Progress in reducing the global burden of TB stalled during the COVID-19 pandemic; an estimated 10.6 million persons became [...]

Published
2024
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6. Rifampicin resistant Mycobacterium tuberculosis in Vietnam, 2020–2022

Author

Van Nguyen, Hung, Binh Nguyen, Hoa, Thu Ha, Doan, Thi Huong, Dinh, Ngoc Trung, Vu, Thi Thuy Ngoc, Khieu, Huyen Trang, Tran, Vu Thi Ngoc, Ha, Trinh Thi Bich, Tram, Le Pham Tien, Trieu, Nguyen Hong, Hanh, Phan Trieu, Phu, Kim Lan, Luong, Lan, Kim, Ngoc Hue, Ngo, Thi Le Huong, Nguyen, Le Thi Ngoc Thao, Tran, Le Quang, Nguyen, Do Dang Anh, Thu, Hữu Lân, Nguyễn, Van Vinh, Truong, Thi Minh Ha, Dang, Thuong Dat, Phan, Phuc Hai, Nguyen, Crook, Derrick W., Thuy Thuong Thuong, Nguyen, Viet Nguyen, Nhung, Thwaites, Guy E., and Walker, Timothy M.

Published
2024
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8. Aetiology and Potential Animal Exposure in Central Nervous System Infections in Vietnam

Author

Brindle, Hannah E., Nadjm, Behzad, Choisy, Marc, Christley, Rob, Griffiths, Michael, Baker, Stephen, Bryant, Juliet E., Campbell, James I., Nguyen, Van Vinh Chau, Nguyen, Thi Ngoc Diep, Vu, Ty Thi Hang, Nguyen, Van Hung, Hoang, Bao Long, Le, Xuan Luat, Pham, Ha My, Ta, Thi Dieu Ngan, Ho, Dang Trung Nghia, Tran, Thua Nguyen, Nguyen, Thi Han Ny, Tran, My Phuc, Pham, Thi Hong Phuong, Le, Van Tan, Nguyen, Dac Thuan, Hau, Thi Thu Trang, Nguyen, Ngoc Vinh, Wertheim, Heiman F. L., Thwaites, Guy E., and van Doorn, H. Rogier

Published
2022
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9. Xpert MTB/RIF Ultra for the Diagnosis of Tuberculous Meningitis: A Small Step Forward

Author

Donovan, Joseph, Cresswell, Fiona V, Thuong, Nguyen Thuy Thuong, Boulware, David R, Thwaites, Guy E, Bahr, Nathan C, Aarnoutse, Rob E, Anderson, Suzanne TB, Bang, Nguyen D, Boyles, Tom, te Brake, Lindsey HM, Chandra, Satish, Chow, Felicia C, van Crevel, Reinout, Davis, Angharad G, Dian, Sofiati, Dooley, Kelly E, Figaji, Anthony, Ganiem, A Rizal, Garg, Ravindra Kumar, Gibb, Diana M, Hamers, Raph L, Hiep, Nguyen TT, Imran, Darma, Imron, Akhmad, Jain, Sanjay K, Jain, Sunil K, Kalita, Jayantee, Kumar, Rashmi, Kumar, Vinod, van Laarhoven, Arjan, Lai, Rachel P-J, Manesh, Abi, Marais, Suzaan, Mave, Vidya, Meintjes, Graeme, Meya, David B, Misra, Usha K, Modi, Manish, Ordonez, Alvaro A, Phu, Nguyen H, Pradhan, Sunil, Prasad, Kameshwar, Proust, Alize M, Ramakrishnan, Lalita, Rohlwink, Ursula, Ruslami, Rovina, Schoeman, Johannes F, Seddon, James A, Sharma, Kusum, Siddiqi, Omar, Solomons, Regan S, Thuong, Nguyen TT, van Toorn, Ronald, Tucker, Elizabeth W, Wasserman, Sean A, and Wilkinson, Robert J

Subjects
Rare Diseases, Tuberculosis, Infectious Diseases, 4.2 Evaluation of markers and technologies, Detection, screening and diagnosis, Good Health and Well Being, Diagnostic Tests, Routine, Humans, Molecular Diagnostic Techniques, Mycobacterium tuberculosis, Sensitivity and Specificity, Tuberculosis, Meningeal, Tuberculous Meningitis International Research Consortium, Ultra, Xpert, cerebrospinal fluid, diagnosis, tuberculous meningitis, Biological Sciences, Medical and Health Sciences, Microbiology
Abstract

The delayed diagnosis of tuberculous meningitis (TBM) leads to poor outcomes, yet the current diagnostic methods for identifying Mycobacterium tuberculosis in cerebrospinal fluid (CSF) are inadequate. The first comparative study of the new GeneXpert MTB/RIF Ultra (Xpert Ultra) for TBM diagnosis suggested increased sensitivity of Xpert Ultra. Two subsequent studies have shown Xpert Ultra has improved sensitivity, but has insufficient negative predictive value to exclude TBM. Collecting and processing large volumes of CSF for mycobacterial testing are important for optimal diagnostic test performance. But clinical, radiological, and laboratory parameters remain essential for TBM diagnosis and empiric therapy is often needed. We therefore caution against the use of Xpert Ultra as a single diagnostic test for TBM; it cannot be used to "rule out" TBM.

Published
2020

10. Mass drug administrations with dihydroartemisinin-piperaquine and single low dose primaquine to eliminate Plasmodium falciparum have only a transient impact on Plasmodium vivax: Findings from randomised controlled trials

Author

Phommasone, Koukeo, van Leth, Frank, Peto, Thomas J, Landier, Jordi, Nguyen, Thuy-Nhien, Tripura, Rupam, Pongvongsa, Tiengkham, Lwin, Khin Maung, Kajeechiwa, Ladda, Thwin, May Myo, Parker, Daniel M, Wiladphaingern, Jacher, Nosten, Suphak, Proux, Stephane, Nguon, Chea, Davoeung, Chan, Rekol, Huy, Adhikari, Bipin, Promnarate, Cholrawee, Chotivanich, Kesinee, Hanboonkunupakarn, Borimas, Jittmala, Podjanee, Cheah, Phaik Yeong, Dhorda, Mehul, Imwong, Mallika, Mukaka, Mavuto, Peerawaranun, Pimnara, Pukrittayakamee, Sasithon, Newton, Paul N, Thwaites, Guy E, Day, Nicholas PJ, Mayxay, Mayfong, Hien, Tran Tinh, Nosten, Francois H, Cobelens, Frank, Dondorp, Arjen M, White, Nicholas J, and von Seidlein, Lorenz

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Clinical Sciences, Rare Diseases, Vector-Borne Diseases, Prevention, Clinical Trials and Supportive Activities, Infectious Diseases, Clinical Research, Malaria, Infection, Good Health and Well Being, Adolescent, Adult, Antimalarials, Artemisinins, Cambodia, Child, Female, Humans, Malaria, Falciparum, Malaria, Vivax, Male, Mass Drug Administration, Myanmar, Prevalence, Primaquine, Quinolines, Recurrence, Treatment Outcome, Vietnam, Young Adult, General Science & Technology
Abstract

BackgroundMass administrations of antimalarial drugs (MDA) have reduced the incidence and prevalence of P. falciparum infections in a trial in the Greater Mekong Subregion. Here we assess the impact of the MDA on P. vivax infections.MethodsBetween May 2013 and July 2017, four villages in each Myanmar, Vietnam, Cambodia and Lao PDR were selected based on high prevalence of P. falciparum infections. Eight of the 16 villages were randomly assigned to receive MDA consisting of three-monthly rounds of three-day courses of dihydroartemisinin-piperaquine and, except in Cambodia, a single low-dose of primaquine. Cross-sectional surveys were conducted at quarterly intervals to detect Plasmodium infections using ultrasensitive qPCR. The difference in the cumulative incidence between the groups was assessed through a discrete time survival approach, the difference in prevalence through a difference-in-difference analysis, and the difference in the number of participants with a recurrence of P. vivax infection through a mixed-effect logistic regression.Results3,790 (86%) residents in the intervention villages participated in at least one MDA round, of whom 2,520 (57%) participated in three rounds. The prevalence of P. vivax infections fell from 9.31% to 0.89% at month 3 but rebounded by six months to 5.81%. There was no evidence that the intervention reduced the cumulative incidence of P.vivax infections (95% confidence interval [CI] Odds ratio (OR): 0.29 to 1.36). Similarly, there was no evidence of MDA related reduction in the number of participants with at least one recurrent infection (OR: 0.34; 95% CI: 0.08 to 1.42).ConclusionMDA with schizontocidal drugs had a lasting effect on P. falciparum infections but only a transient effect on the prevalence of P. vivax infections. Radical cure with an 8-aminoquinoline will be needed for the rapid elimination of vivax malaria.

Published
2020

11. The impact of targeted malaria elimination with mass drug administrations on falciparum malaria in Southeast Asia: A cluster randomised trial.

Author

von Seidlein, Lorenz, Peto, Thomas J, Landier, Jordi, Nguyen, Thuy-Nhien, Tripura, Rupam, Phommasone, Koukeo, Pongvongsa, Tiengkham, Lwin, Khin Maung, Keereecharoen, Lilly, Kajeechiwa, Ladda, Thwin, May Myo, Parker, Daniel M, Wiladphaingern, Jacher, Nosten, Suphak, Proux, Stephane, Corbel, Vincent, Tuong-Vy, Nguyen, Phuc-Nhi, Truong Le, Son, Do Hung, Huong-Thu, Pham Nguyen, Tuyen, Nguyen Thi Kim, Tien, Nguyen Thanh, Dong, Le Thanh, Hue, Dao Van, Quang, Huynh Hong, Nguon, Chea, Davoeung, Chan, Rekol, Huy, Adhikari, Bipin, Henriques, Gisela, Phongmany, Panom, Suangkanarat, Preyanan, Jeeyapant, Atthanee, Vihokhern, Benchawan, van der Pluijm, Rob W, Lubell, Yoel, White, Lisa J, Aguas, Ricardo, Promnarate, Cholrawee, Sirithiranont, Pasathorn, Malleret, Benoit, Rénia, Laurent, Onsjö, Carl, Chan, Xin Hui, Chalk, Jeremy, Miotto, Olivo, Patumrat, Krittaya, Chotivanich, Kesinee, Hanboonkunupakarn, Borimas, Jittmala, Podjanee, Kaehler, Nils, Cheah, Phaik Yeong, Pell, Christopher, Dhorda, Mehul, Imwong, Mallika, Snounou, Georges, Mukaka, Mavuto, Peerawaranun, Pimnara, Lee, Sue J, Simpson, Julie A, Pukrittayakamee, Sasithon, Singhasivanon, Pratap, Grobusch, Martin P, Cobelens, Frank, Smithuis, Frank, Newton, Paul N, Thwaites, Guy E, Day, Nicholas PJ, Mayxay, Mayfong, Hien, Tran Tinh, Nosten, Francois H, Dondorp, Arjen M, and White, Nicholas J

Subjects
Humans, Malaria, Falciparum, Antimalarials, Cluster Analysis, Cross-Over Studies, Drug Resistance, Multiple, Adolescent, Adult, Child, Asia, Southeastern, Female, Male, Young Adult, Disease Eradication, Mass Drug Administration, Malaria, Falciparum, Drug Resistance, Multiple, Asia, Southeastern, General & Internal Medicine, Medical and Health Sciences
Abstract

BackgroundThe emergence and spread of multidrug-resistant Plasmodium falciparum in the Greater Mekong Subregion (GMS) threatens global malaria elimination efforts. Mass drug administration (MDA), the presumptive antimalarial treatment of an entire population to clear the subclinical parasite reservoir, is a strategy to accelerate malaria elimination. We report a cluster randomised trial to assess the effectiveness of dihydroartemisinin-piperaquine (DP) MDA in reducing falciparum malaria incidence and prevalence in 16 remote village populations in Myanmar, Vietnam, Cambodia, and the Lao People's Democratic Republic, where artemisinin resistance is prevalent.Methods and findingsAfter establishing vector control and community-based case management and following intensive community engagement, we used restricted randomisation within village pairs to select 8 villages to receive early DP MDA and 8 villages as controls for 12 months, after which the control villages received deferred DP MDA. The MDA comprised 3 monthly rounds of 3 daily doses of DP and, except in Cambodia, a single low dose of primaquine. We conducted exhaustive cross-sectional surveys of the entire population of each village at quarterly intervals using ultrasensitive quantitative PCR to detect Plasmodium infections. The study was conducted between May 2013 and July 2017. The investigators randomised 16 villages that had a total of 8,445 residents at the start of the study. Of these 8,445 residents, 4,135 (49%) residents living in 8 villages, plus an additional 288 newcomers to the villages, were randomised to receive early MDA; 3,790 out of the 4,423 (86%) participated in at least 1 MDA round, and 2,520 out of the 4,423 (57%) participated in all 3 rounds. The primary outcome, P. falciparum prevalence by month 3 (M3), fell by 92% (from 5.1% [171/3,340] to 0.4% [12/2,828]) in early MDA villages and by 29% (from 7.2% [246/3,405] to 5.1% [155/3,057]) in control villages. Over the following 9 months, the P. falciparum prevalence increased to 3.3% (96/2,881) in early MDA villages and to 6.1% (128/2,101) in control villages (adjusted incidence rate ratio 0.41 [95% CI 0.20 to 0.84]; p = 0.015). Individual protection was proportional to the number of completed MDA rounds. Of 221 participants with subclinical P. falciparum infections who participated in MDA and could be followed up, 207 (94%) cleared their infections, including 9 of 10 with artemisinin- and piperaquine-resistant infections. The DP MDAs were well tolerated; 6 severe adverse events were detected during the follow-up period, but none was attributable to the intervention.ConclusionsAdded to community-based basic malaria control measures, 3 monthly rounds of DP MDA reduced the incidence and prevalence of falciparum malaria over a 1-year period in areas affected by artemisinin resistance. P. falciparum infections returned during the follow-up period as the remaining infections spread and malaria was reintroduced from surrounding areas. Limitations of this study include a relatively small sample of villages, heterogeneity between villages, and mobility of villagers that may have limited the impact of the intervention. These results suggest that, if used as part of a comprehensive, well-organised, and well-resourced elimination programme, DP MDA can be a useful additional tool to accelerate malaria elimination.Trial registrationClinicalTrials.gov NCT01872702.

Published
2019

12. Neurocognitive and functional impairment in adult and paediatric tuberculous meningitis

Author

Davis, Angharad G, Nightingale, Sam, Springer, Priscilla E, Solomons, Regan, Arenivas, Ana, Wilkinson, Robert J, Anderson, Suzanne T, Chow, Felicia C, Aarnoutse, Rob E, Anderson, Suzanne TB, Bahr, Nathan C, Bang, Nguyen D, Boulware, David R, Boyles, Tom, Brake, Lindsey HM te, Chandra, Satish, Cresswell, Fiona V, van Crevel, Reinout, Dian, Sofiati, Donovan, Joseph, Dooley, Kelly E, Figaji, Anthony, Ganiem, A Rizal, Garg, Ravindra Kumar, Gibb, Diana M, Hamers, Raph L, Hiep, Nguyen TT, Imran, Darma, Imron, Akhmad, Jain, Sanjay K, Jain, Sunil K, Jeejeebhoy, Byramee, Kalita, Jayantee, Kumar, Rashmi, Kumar, Vinod, van Laarhoven, Arjan, Lai, Rachel P-J, Manesh, Abi, Marais, Suzaan, Mave, Vidya, Meintjes, Graeme, Meya, David B, Misra, Usha K, Modi, Manish, Ordonez, Alvaro A, Phu, Nguyen H, Pradhan, Sunil, Prasad, Kameshwar, Proust, Alize M, Ramakrishnan, Lalita, Rohlwink, Ursula, Ruslami, Rovina, Schoeman, Johannes F, Seddon, James A, Sharma, Kusum, Siddiqi, Omar, Solomons, Regan S, Thuong, Nguyen TT, Thwaites, Guy E, van Toorn, Ronald, Tucker, Elizabeth W, and Wasserman, Sean A

Subjects
Biomedical and Clinical Sciences, Health Sciences, Neurosciences, Brain Disorders, Behavioral and Social Science, Mental health, Good Health and Well Being, Tuberculous Meningitis International Research Consortium, Functional, Neurobehavioural, Neurocognitive, Neurodevelopmental, Psychiatric, Tuberculous Meningitis, Biomedical and clinical sciences, Health sciences
Abstract

In those who survive tuberculous meningitis (TBM), the long-term outcome is uncertain; individuals may suffer neurocognitive, functional and psychiatric impairment, which may significantly affect their ability to lead their lives as they did prior to their diagnosis of TBM. In children who survive, severe illness has occurred at a crucial timepoint in their development, which can lead to behavioural and cognitive delay. The extent and nature of this impairment is poorly understood, particularly in adults. This is in part due to a lack of observational studies in this area but also inconsistent inclusion of outcome measures which can quantify these deficits in clinical studies. This leads to a paucity of appropriate rehabilitative therapies available for these individuals and their caregivers, as well as burden at a socioeconomic level. In this review, we discuss what is known about neurocognitive impairment in TBM, draw on lessons learnt from other neurological infections and discuss currently available and emerging tools to evaluate function and cognition and their value in TBM. We make recommendations on which measures should be used at what timepoints to assess for impairment, with a view to optimising and standardising assessment of neurocognitive and functional impairment in TBM research.

Published
2019

13. Establishing the cascade of care for patients with tuberculous meningitis

Author

Imran, Darma, Hill, Philip C, McKnight, Jacob, van Crevel, Reinout, Aarnoutse, Rob E, Anderson, Suzanne TB, Bahr, Nathan C, Bang, Nguyen D, Boulware, David R, Boyles, Tom, Brake, Lindsey HM te, Chandra, Satish, Chow, Felicia C, Cresswell, Fiona V, Davis, Angharad G, Dian, Sofiati, Donovan, Joseph, Dooley, Kelly E, Figaji, Anthony, Ganiem, A Rizal, Garg, Ravindra Kumar, Gibb, Diana M, Hamers, Raph L, Hiep, Nguyen TT, Imron, Akhmad, Jain, Sanjay K, Jain, Sunil K, Jeejeebhoy, Byramee, Kalita, Jayantee, Kumar, Rashmi, Kumar, Vinod, van Laarhoven, Arjan, Lai, Rachel P-J, Manesh, Abi, Marais, Suzaan, Mave, Vidya, Meintjes, Graeme, Meya, David B, Misra, Usha K, Modi, Manish, Ordonez, Alvaro A, Phu, Nguyen H, Pradhan, Sunil, Prasad, Kameshwar, Proust, Alize M, Ramakrishnan, Lalita, Rohlwink, Ursula, Ruslami, Rovina, Schoeman, Johannes F, Seddon, James A, Sharma, Kusum, Siddiqi, Omar, Solomons, Regan S, Thuong, Nguyen TT, Thwaites, Guy E, van Toorn, Ronald, Tucker, Elizabeth W, Wasserman, Sean A, and Wilkinson, Robert J

Subjects
Health Services and Systems, Biomedical and Clinical Sciences, Health Sciences, Infectious Diseases, Health Services, Tuberculosis, HIV/AIDS, Clinical Research, Rare Diseases, 8.1 Organisation and delivery of services, Health and social care services research, Infection, Good Health and Well Being, Tuberculous Meningitis International Research Consortium, cascade of care, health systems, meningitis, patient pathway analysis, tuberculosis, Biomedical and clinical sciences, Health sciences
Abstract

Meningitis is a relatively rare form of tuberculosis, but it carries a high mortality rate, reaching 50% in some settings, with higher rates among patients with HIV co-infection and those with drug-resistant disease. Most studies of tuberculosis meningitis (TBM) tend to focus on better diagnosis, drug treatment and supportive care for patients in hospital. However, there is significant variability in mortality between settings, which may be due to specific variation in the availability and quality of health care services, both prior to, during, and after hospitalization. Such variations have not been studied thoroughly, and we therefore present a theoretical framework that may help to identify where efforts should be focused in providing optimal services for TBM patients. As a first step, we propose an adjusted cascade of care for TBM and patient pathway studies that might help identify factors that account for losses and delays across the cascade. Many of the possible gaps in the TBM cascade are related to health systems factors; we have selected nine domains and provide relevant examples of systems factors for TBM for each of these domains that could be the basis for a health needs assessment to address such gaps. Finally, we suggest some immediate action that could be taken to help make improvements in services. Our theoretical framework will hopefully lead to more health system research and improved care for patients suffering from this most dangerous form of tuberculosis.

Published
2019

14. Correction: Aetiology and Potential Animal Exposure in Central Nervous System Infections in Vietnam

Author

Brindle, Hannah E., Nadjm, Behzad, Choisy, Marc, Christley, Rob, Griffiths, Michael, Baker, Stephen, Bryant, Juliet E., Campbell, James I., Nguyen, Van Vinh Chau, Nguyen, Thi Ngoc Diep, Vu, Ty Thi Hang, Nguyen, Van Hung, Hoang, Bao Long, Le, Xuan Luat, Pham, Ha My, Ta, Thi Dieu Ngan, Ho, Dang Trung Nghia, Tran, Thua Nguyen, Nguyen, Thi Han Ny, Tran, My Phuc, Pham, Thi Hong Phuong, Le, Van Tan, Nguyen, Dac Thuan, Hau, Thi Thu Trang, Nguyen, Ngoc Vinh, Wertheim, Heiman F. L., Thwaites, Guy E., and van Doorn, H. Rogier

Published
2022
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15. Human versus equine intramuscular antitoxin, with or without human intrathecal antitoxin, for the treatment of adults with tetanus: a 2 × 2 factorial randomised controlled trial

Author

Van Hao, Nguyen, Loan, Huynh Thi, Yen, Lam Minh, Kestelyn, Evelyne, Hong, Duc Du, Thuy, Duong Bich, Nguyen, Nguyen Thanh, Duong, Ha Thi Hai, Thuy, Tran Thi Diem, Nhat, Phung Tran Huy, Khanh, Phan Nguyen Quoc, Dung, Nguyen Thi Phuong, Phu, Nguyen Hoan, Phong, Nguyen Thanh, Lieu, Pham Thi, Tuyen, Pham Thi, Hanh, Bui Thi Bich, Nghia, Ho Dang Trung, Oanh, Pham Kieu Nguyet, Tho, Phan Vinh, Tan Thanh, Tran, Turner, Hugo C, van Doorn, H Rogier, Van Tan, Le, Wyncoll, Duncan, Day, Nicholas PJ, Geskus, Ronald B, Thwaites, Guy E, Van Vinh Chau, Nguyen, and Thwaites, C Louise

Published
2022
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16. Tumour microbiomes and Fusobacterium genomics in Vietnamese colorectal cancer patients

Author

Tran, Hoang N. H., Thu, Trang Nguyen Hoang, Nguyen, Phu Huu, Vo, Chi Nguyen, Doan, Khanh Van, Nguyen Ngoc Minh, Chau, Nguyen, Ngoc Tuan, Ta, Van Ngoc Duc, Vu, Khuong An, Hua, Thanh Danh, Nguyen, To Nguyen Thi, Van, Tan Trinh, Pham Duc, Trung, Duong, Ba Lap, Nguyen, Phuc Minh, Hoang, Vinh Chuc, Pham, Duy Thanh, Thwaites, Guy E., Hall, Lindsay J., Slade, Daniel J., Baker, Stephen, Tran, Vinh Hung, and Chung The, Hao

Published
2022
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20. Distinctive antibody responses to Mycobacterium tuberculosis in pulmonary and brain infection.

Author

Spatola, Marianna, Nziza, Nadège, Irvine, Edward B, Cizmeci, Deniz, Jung, Wonyeong, Van, Le Hong, Nhat, Le Thanh Hoang, Ha, Vu Thi Ngoc, Phu, Nguyen Hoan, Ho, Dang Trung Nghia, Thwaites, Guy E, Lauffenburger, Douglas A, Fortune, Sarah, Thuong, Nguyen Thuy Thuong, and Alter, Galit

Subjects
COMPLEMENT (Immunology), KILLER cells, TUBERCULOSIS, MYCOBACTERIUM tuberculosis, IMMUNE response, IMMUNOGLOBULIN M, ECULIZUMAB
Abstract

Mycobacterium tuberculosis , the causative agent of tuberculosis (TB), remains a global health burden. While M. tuberculosis is primarily a respiratory pathogen, it can spread to other organs, including the brain and meninges, causing TB meningitis (TBM). However, little is known about the immunological mechanisms that lead to differential disease across organs. Attention has focused on differences in T cell responses in the control of M. tuberculosis in the lungs, but emerging data point to a role for antibodies, as both biomarkers of disease control and as antimicrobial molecules. Given an increasing appreciation for compartmentalized antibody responses across the blood–brain barrier, here we characterized the antibody profiles across the blood and brain compartments in TBM and determined whether M. tuberculosis -specific humoral immune responses differed between M. tuberculosis infection of the lung (pulmonary TB) and TBM. Using a high throughput systems serology approach, we deeply profiled the antibody responses against 10 different M. tuberculosis antigens, including lipoarabinomannan (LAM) and purified protein derivative (PPD), in HIV-negative adults with pulmonary TB (n = 10) versus TBM (n = 60). Antibody studies included analysis of immunoglobulin isotypes (IgG, IgM, IgA) and subclass levels (IgG1–4) and the capacity of M. tuberculosis -specific antibodies to bind to Fc receptors or C1q and to activate innate immune effector functions (complement and natural killer cell activation; monocyte or neutrophil phagocytosis). Machine learning methods were applied to characterize serum and CSF responses in TBM, identify prognostic factors associated with disease severity, and define the key antibody features that distinguish TBM from pulmonary TB. In individuals with TBM, we identified CSF-specific antibody profiles that marked a unique and compartmentalized humoral response against M. tuberculosis , characterized by an enrichment of M. tuberculosis -specific antibodies able to robustly activate complement and drive phagocytosis by monocytes and neutrophils, all of which were associated with milder TBM severity at presentation. Moreover, individuals with TBM exhibited M. tuberculosis -specific antibodies in the serum with an increased capacity to activate phagocytosis by monocytes, compared with individuals with pulmonary TB, despite having lower IgG titres and Fcγ receptor-binding capacity. Collectively, these data point to functionally divergent humoral responses depending on the site of infection (i.e. lungs versus brain) and demonstrate a highly compartmentalized M. tuberculosis -specific antibody response within the CSF in TBM. Moreover, our results suggest that phagocytosis- and complement-mediating antibodies may promote attenuated neuropathology and milder TBM disease. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Xpert MTB/RIF Ultra versus Xpert MTB/RIF for the diagnosis of tuberculous meningitis: a prospective, randomised, diagnostic accuracy study

Author

Donovan, Joseph, Thu, Do Dang Anh, Phu, Nguyen Hoan, Dung, Vu Thi Mong, Quang, Tran Phu, Nghia, Ho Dang Trung, Oanh, Pham Kieu Nguyet, Nhu, Tran Bao, Chau, Nguyen Van Vinh, Ha, Vu Thi Ngoc, Hang, Vu Thi Ty, Trinh, Dong Huu Khanh, Geskus, Ronald B, Tan, Le Van, Thuong, Nguyen Thuy Thuong, and Thwaites, Guy E

Published
2020
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25. Rifampicin tolerance and growth fitness among isoniazid-resistant clinical Mycobacterium tuberculosis isolates: an in-vitro longitudinal study

Author

Srinivasan, Vijay, primary, Bao, Nguyen Le Hoai, additional, Vinh, Dao Nguyen, additional, Nhat, Le Thanh Hoang, additional, Thu, Do Dang Anh, additional, Quang, Nguyen Le, additional, Trieu, Le Pham Tien, additional, Nhung, Hoang Ngoc, additional, Ha, Vu Thi Ngoc, additional, Thai, Phan Vuong Khac, additional, Ha, Dang Thi Minh, additional, Lan, Nguyen Huu, additional, Caws, Maxine, additional, Thwaites, Guy E., additional, Javid, Babak, additional, and Thuong, Nguyen Thuy Thuong, additional

Published
2024
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26. Author Response: Whole blood transcriptional profiles and the pathogenesis of tuberculous meningitis

Author

Hai, Hoang Thanh, primary, Nhat, Le Thanh Hoang, additional, Tram, Trinh Thi Bich, additional, Nath, Artika P, additional, Donovan, Joseph, additional, Thu, Nguyen Thi Anh, additional, Van Thanh, Dang, additional, Bang, Nguyen Duc, additional, Ha, Dang Thi Minh, additional, Phu, Nguyen Hoan, additional, Nghia, Ho Dang Trung, additional, Van, Le Hong, additional, Inouye, Michael, additional, Thwaites, Guy E, additional, and Thuong, Nguyen Thuy Thuong, additional

Published
2024
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27. Whole blood transcriptional profiles and the pathogenesis of tuberculous meningitis

Author

Hai, Hoang Thanh, primary, Nhat, Le Thanh Hoang, additional, Tram, Trinh Thi Bich, additional, Nath, Artika P, additional, Donovan, Joseph, additional, Thu, Nguyen Thi Anh, additional, Van Thanh, Dang, additional, Bang, Nguyen Duc, additional, Ha, Dang Thi Minh, additional, Phu, Nguyen Hoan, additional, Nghia, Ho Dang Trung, additional, Van, Le Hong, additional, Inouye, Michael, additional, Thwaites, Guy E, additional, and Thuong, Nguyen Thuy Thuong, additional

Published
2024
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28. GeneXpert MTB/Rif to Diagnose Tuberculous Meningitis: Perhaps the First Test but not the Last

Author

Bahr, Nathan C, Marais, Suzaan, Caws, Maxine, van Crevel, Reinout, Wilkinson, Robert J, Tyagi, Jaya S, Thwaites, Guy E, Boulware, David R, Aarnoutse, Rob, Van Crevel, Reinout, van Laarhoven, Aarjan, Dian, Sofiati, Cronan, Mark R, Tobin, David, Dooley, Kelly, Dunstan, Sarah, Feng, Guo-dong, Shi, Xiaodan, Wang, Ting, Figaji, Anthony, McIlleron, Helen, Meintjes, Graeme, Rohlwink, Ursula, Rizal, Ahmad, Ruslami, Rovina, Garg, Ravindra K, Gupta, Mudit, Gupta, Rakesh K, Gupta, Sneha, Savic, Rada, Heemskerk, Anna D, Nguyễn, Thương Thụy Thương, Nguyễn, Mai Thị Hoàng, Srinivasan, Vijay, Thwaites, Guy, Trần, Trâm Thị Bích, Trần, Thịnh Thi Vân, Trần, Anh Thi Ngọc, Võ, Trang Hồng Yêng, Wolbers, Marcel, Kalita, Jayantee, Misra, Usha K, Lai, Rachel, Marais, Ben J, Trinh, Mai Quỳnh, Nguyễn, Bằng Đức, Nguyễn, Yến Bích, Patel, Vinod, Pouplin, Thomas, Ramakrishnan, Lalita, Schoeman, Johan F, Solomons, Regan, Van Toorn, Ronald, Seddon, James, Shah, Javeed, and Visser, Douwe H

Subjects
Rare Diseases, Good Health and Well Being, DNA, Bacterial, Humans, Mycobacterium tuberculosis, Nucleic Acid Amplification Techniques, Tuberculosis, Meningeal, Tuberculous Meningitis International Research Consortium, diagnosis, guideline, meningitis, perspective, tuberculous, Biological Sciences, Medical and Health Sciences, Microbiology
Abstract

Tuberculous meningitis (TBM) is the most severe form of tuberculous with substantial mortality. In May 2015, 54 researchers from 10 countries met in Da Lat, Vietnam, to discuss advances in TBM. Among the attendees were researchers involved in pivotal studies on the use of Xpert MTB/Rif for TBM diagnosis. Attendees discussed the 2014 World Health Organization strong recommendation favoring the use of Xpert "in preference to conventional microscopy and culture as the initial diagnostic test for cerebrospinal fluid (CSF) if the sample volume is low or if additional specimens cannot be obtained to make a quick diagnosis." Attendees were concerned that the limitations of Xpert testing for TBM are not emphasized. Clear guidance is needed for the investigational pathway for TBM, including recommendations on the diagnostic package of investigations, which does not stop with Xpert testing. Second, emphasis on the large CSF volumes (ideally 8-10 mL) needed for Xpert testing is required. Guidelines should also emphasize that TBM is a medical emergency and early treatment reduces mortality.

Published
2016

29. The effect of M. tuberculosis lineage on clinical phenotype

Author

Du, Duc Hong, primary, Geskus, Ronald B., additional, Zhao, Yanlin, additional, Codecasa, Luigi Ruffo, additional, Cirillo, Daniela Maria, additional, van Crevel, Reinout, additional, Pascapurnama, Dyshelly Nurkartika, additional, Chaidir, Lidya, additional, Niemann, Stefan, additional, Diel, Roland, additional, Omar, Shaheed Vally, additional, Grandjean, Louis, additional, Rokadiya, Sakib, additional, Ortitz, Arturo Torres, additional, Lân, Nguyễn Hữu, additional, Hà, Đặng Thị Minh, additional, Smith, E. Grace, additional, Robinson, Esther, additional, Dedicoat, Martin, additional, Nhat, Le Thanh Hoang, additional, Thwaites, Guy E., additional, Van, Le Hong, additional, Thuong, Nguyen Thuy Thuong, additional, and Walker, Timothy M., additional

Published
2023
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31. Age-seroprevalence curves for the multi-strain structure of influenza A virus

Author

Vinh, Dao Nguyen, Nhat, Nguyen Thi Duy, de Bruin, Erwin, Vy, Nguyen Ha Thao, Thao, Tran Thi Nhu, Phuong, Huynh Thi, Anh, Pham Hong, Todd, Stacy, Quan, Tran Minh, Thanh, Nguyen Thi Le, Lien, Nguyen Thi Nam, Ha, Nguyen Thi Hong, Hong, Tran Thi Kim, Thai, Pham Quang, Choisy, Marc, Nguyen, Tran Dang, Simmons, Cameron P., Thwaites, Guy E., Clapham, Hannah E., Chau, Nguyen Van Vinh, Koopmans, Marion, and Boni, Maciej F.

Published
2021
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34. Clinical and aetiological study of hand, foot and mouth disease in southern Vietnam, 2013–2015: Inpatients and outpatients

Author

Hoang, Minh Tu Van, Nguyen, To Anh, Tran, Tan Thanh, Vu, Thi Ty Hang, Le, Nguyen Truc Nhu, Nguyen, Thi Han Ny, Le, Thanh Hoang Nhat, Nguyen, Thi Thu Hong, Nguyen, Thanh Hung, Le, Nguyen Thanh Nhan, Truong, Huu Khanh, Du, Tuan Quy, Ha, Manh Tuan, Ho, Lu Viet, Do, Chau Viet, Nguyen, Tran Nam, Nguyen, Thi My Thanh, Sabanathan, Saraswathy, Phan, Tu Qui, Nguyen Van, Vinh Chau, Thwaites, Guy E., Wills, Bridget, Thwaites, C. Louise, Le, Van Tan, and van Doorn, H. Rogier

Published
2019
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36. Rifampicin tolerance and growth fitness among isoniazid-resistant clinical Mycobacterium tuberculosis isolates: an in-vitro longitudinal study

Author

Srinivasan, Vijay, primary, Bao, Nguyen Le Hoai, additional, Vinh, Dao Nguyen, additional, Thanh Hoang Le, Nhat, additional, Thu, Do DA, additional, Quang, Nguyen Le, additional, Trieu, Le Pham Tien, additional, Nhung, Hoang Ngoc, additional, Ha, Vu Thi Ngoc, additional, Thai, Phan Vuong Khac, additional, Ha, Dang Thi Minh, additional, Lan, Nguyen Huu, additional, Caws, Maxine, additional, Thwaites, Guy E, additional, Javid, Babak, additional, and Thuong, Nguyen TT, additional

Published
2023
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37. Adjunctive Dexamethasone for Tuberculous Meningitis in HIV-Positive Adults

Author

Donovan, Joseph, primary, Bang, Nguyen D., additional, Imran, Darma, additional, Nghia, Ho D.T., additional, Burhan, Erlina, additional, Huong, Dau T.T., additional, Hiep, Nguyen T.T., additional, Ngoc, Lam H.B., additional, Thanh, Dang V., additional, Thanh, Nguyen T., additional, Wardhani, Anna L.S., additional, Maharani, Kartika, additional, Gasmara, Cakra P., additional, Hanh, Nguyen H.H., additional, Oanh, Pham K.N., additional, Estiasari, Riwanti, additional, Thu, Do D.A., additional, Kusumaningrum, Ardiana, additional, Dung, Le T., additional, Giang, Do C., additional, Ha, Dang T.M., additional, Lan, Nguyen H., additional, Chau, Nguyen V.V., additional, Nguyet, Nguyen T.M., additional, Geskus, Ronald B., additional, Thuong, Nguyen T.T., additional, Kestelyn, Evelyne, additional, Hamers, Raph L., additional, Phu, Nguyen H., additional, and Thwaites, Guy E., additional

Published
2023
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38. Whole blood transcriptional profiles and the pathogenesis of tuberculous meningitis

Author

Hai, Hoang Thanh, primary, Nhat, Le Thanh Hoang, additional, Tram, Trinh Thi Bich, additional, Nath, Artika P, additional, Donovan, Joseph, additional, Thu, Nguyen Thi Anh, additional, Thanh, Dang Van, additional, Bang, Nguyen Duc, additional, Ha, Dang Thi Minh, additional, Phu, Nguyen Hoan, additional, Nghia, Ho Dang Trung, additional, Van, Le Hong, additional, Inouye, Michael, additional, Thwaites, Guy E, additional, and Thuong, Nguyen Thuy Thuong, additional

Published
2023
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40. Prognostic Models for 9-Month Mortality in Tuberculous Meningitis

Author

Le Thi Phuong Thao, Heemskerk, A. Dorothee, Geskus, Ronald B., Mai, Nguyen Thi Hoang, Ha, Dang Thi Minh, Chau, Tran Thi Hong, Phu, Nguyen Hoan, Van Vinh Chau, Nguyen, Caws, Maxine, Lan, Nguyen Huu, Thu, Do Dang Anh, Thuong, Nguyen Thuy Thuong, Day, Jeremy, Farrar, Jeremy J., Torok, M. Estee, Bang, Nguyen Duc, Thwaites, Guy E., and Wolbers, Marcel

Published
2018

43. List of Contributors

Author

Acosta, Anna M., primary, Acuin, Jose M., additional, Adam, Rodney D., additional, Afroze, Farzana, additional, Ahmed, Nadia, additional, Ahmed, Sabeena, additional, Ahmed, Tahmeed, additional, Ahmed, A.M. Shamsir, additional, Ali, S. Asad, additional, Ali, Ibne K., additional, Alroy, Karen A., additional, Ananthakrishnan, Ashwin N., additional, Ansong, Daniel, additional, Anstead, Gregory M., additional, Appleby, Laura J., additional, Armah, George E., additional, Aronson, Naomi E., additional, Aston, Stephen J., additional, Barnett, Elizabeth D., additional, Bartelt, Luther A., additional, Bates, Imelda, additional, Bausch, Daniel G., additional, Beadling, Charles W., additional, Beeching, Nicholas J., additional, Bennish, Michael L., additional, Bern, Caryn, additional, Bernstein, Wendy B., additional, Bird, Brian H., additional, Bloom, Allyson K., additional, Bodeker, Gerard, additional, Boyer Chammard, Timothée, additional, Bradsher, Robert W., additional, Brooker, Simon J., additional, Brooks, W. Abdullah, additional, Brouqui, Philippe, additional, Brown, Michael, additional, Brown, Michael R., additional, Broyles, Laura N., additional, Bruschi, Fabrizio, additional, Bundy, Donald A.P., additional, Burton, Matthew, additional, Cabrera-Sosa, Luis, additional, Callahan, Michael V., additional, Carapetis, Jonathan R., additional, Cardemil, Cristina V., additional, Carrol, Enitan D., additional, Caswell, Rachel, additional, Caumes, Eric, additional, Cavalheiro, Ana P., additional, Chan, Abner L., additional, Charunwatthana, Prakaykaew, additional, Checkley, Anna M., additional, Chen, Lin H., additional, Chher, Tepirou, additional, Chiong, Charlotte M., additional, Chisti, M. Jobayer, additional, Christiani, David C., additional, Clark, Taryn N., additional, Connor, Bradley A., additional, Conway, Devin J., additional, Cooper, Philip J., additional, Cope, Jennifer R., additional, Coughlin, R. Richard, additional, Coulibaly, Yaya I., additional, Coyle, Christina M., additional, Crozier, Ian, additional, Cunliffe, Nigel A., additional, Cupido, Blanche, additional, Curren, Emily J., additional, Danta, Mark, additional, Day, Nicholas P.J., additional, Debboun, Mustapha, additional, DeFraites, Robert F., additional, Dekumyoy, Paron, additional, del Castillo, Maria, additional, den Hoed, Caroline M., additional, de Silva, Nilanthi, additional, Deye, Gregory, additional, Dillingham, Rebecca A., additional, Drancourt, Michel, additional, Durward, Callum S., additional, Eddleston, Michael, additional, El-Kamary, Samer S., additional, Elshaboury, Ramy H., additional, Endtz, Hubert P., additional, Endy, Timothy P., additional, Fang, Shona C., additional, Fawzi, Wafaie, additional, Feasey, Nicholas A., additional, Field, Vanessa K., additional, Fischer, Marc, additional, Forsyth, Kevin, additional, Fournier, Pierre-Edouard, additional, Friedlander, Arthur M., additional, Furin, Jennifer J., additional, Gandhi, Ronak G., additional, Garcia, Hector H., additional, Garcia, Lynne S., additional, Geretti, Anna Maria, additional, Gikas, Achilleas, additional, Gilman, Robert H., additional, Giri, Sidhartha, additional, Gkika, Meropi, additional, Gordon, Melita A., additional, Gosselin, Richard A., additional, Gotuzzo, Eduardo, additional, Gould, Carolyn V., additional, Graeff-Teixeira, Carlos, additional, Graham, Stephen M., additional, Grant, Alison D., additional, Graybill, John R., additional, Graz, Bertrand, additional, Green, Stephen T., additional, Griffiths, Jeffrey K., additional, Griffiths, Michael J., additional, Gryseels, Bruno, additional, Gubler, Duane J., additional, Guhadasan, Rathi, additional, Hall, Aron J., additional, Hamer, Davidson H., additional, Hand, Robert M., additional, Harley, David, additional, Harris, Jason B., additional, Hassall, Oliver, additional, Hay, Roderick J., additional, Hickey, Patrick, additional, Hill, David R., additional, Hills, Susan L., additional, Hobdell, Martin H., additional, Hochberg, Natasha S., additional, Hopkins, Donald R., additional, Hossain, M. Iqbal, additional, Hotez, Peter J., additional, Howard, Cynthia R., additional, Hu, Victor, additional, Hung, Chien-Ching, additional, Islam, Munirul, additional, Iturriza-Gómara, Miren, additional, Joekes, Elizabeth, additional, Johnston, Victoria, additional, Jose, Jo-Ann, additional, Junghanss, Thomas, additional, Kamgno, Joseph, additional, Kampondeni, Sam, additional, Kang, Gagandeep, additional, Kazanjian, Powel, additional, Keshtkar-Jahromi, Maryam, additional, Keshtkar-Jahromi, Marzieh, additional, Keystone, Jay S., additional, Kim, Arthur Y., additional, Kim, Sung-Han, additional, King, Christopher L., additional, Kittitrakul, Chatporn, additional, Kleine, Christian, additional, Klion, Amy D., additional, Knight, Richard, additional, Koren, Michael, additional, Kottilil, Shyamasundaran, additional, Krause, Peter J., additional, Krishna, Sanjeev, additional, Kuhn, Jens H., additional, Kuipers, Ernst J., additional, LaBeaud, Angelle D., additional, Labra, Patrick John P., additional, Lalloo, David G., additional, Lambert, Saba, additional, Lanternier, Fanny, additional, LaRocque, Regina C., additional, Last, Anna, additional, Lawrenson, John, additional, Le, Thuy, additional, Lee, Keun Hwa, additional, Lewis, David A., additional, Libraty, Daniel H., additional, Lo, Nathan C., additional, Lockwood, Diana N.J., additional, Lockwood, Stephen J., additional, Lommerse, Kinke, additional, López-Vélez, Rogelio, additional, Lortholary, Olivier, additional, Mabey, David, additional, Magill, Alan J., additional, Maguiña, Ciro P., additional, Manji, Hadi, additional, Marks, Michael, additional, Maurin, Max, additional, Mayaud, Philippe, additional, Mayosi, Bongani M., additional, M'baya, Bridon, additional, McCarthy, Matthew W., additional, McCartney, Daniel, additional, McCormick, Joseph B., additional, McKew, Stephen, additional, McLellan, Susan L.F., additional, McMinn, Peter C., additional, Mertz, Gregory, additional, Milner, Danny A., additional, Molyneux, Elizabeth M., additional, Montgomery, Susan P., additional, Moonah, Shannon, additional, Moss, William J., additional, Murrell, K. Darwin, additional, Nanda, Neha, additional, Navarro, Eileen E., additional, Ndayizeye, Leonard, additional, Neafie, Ronald C., additional, Negroni, Ricardo, additional, Nelson, Ann M., additional, Newton, Paul N., additional, Nichol, Stuart T., additional, Norman, Francesca F., additional, Nunes, Marcio R.T., additional, Nutman, Thomas B., additional, Nyirenda, Tonney S., additional, Ochoa, Theresa J., additional, O'Farrell, Nigel, additional, Olayemi, Edeghonghon, additional, Oldfield, Edward C., additional, Omidian, Zahra, additional, Ordaya, Eloy E., additional, Paddock, Christopher D., additional, Paessler, Slobodan, additional, Papanikolaou, Ilias C., additional, Paris, Luc, additional, Parry, Christopher M., additional, Patel, Pragna, additional, Peacock, Sharon J., additional, Peeling, Rosanna W., additional, Persson, Hans, additional, Phillips, Jonathan J., additional, Phillips, Richard O., additional, Poovorawan, Kittiyod, additional, Powers, Ann M., additional, Qamar, Farah Naz, additional, Qureshi, Sonia, additional, Rabe, Ingrid B., additional, Rahman, Atif, additional, Rahmati, Elham, additional, Raizes, Elliot, additional, Ramalho-Ortigao, Marcelo, additional, Raoult, Didier, additional, Rein, Michael F., additional, Retik, Alan B., additional, Reynes, Jean-Marc, additional, Rhatigan, Joseph J., additional, Rickard, Jennifer, additional, Riddle, Mark S., additional, Rimoin, Anne W., additional, Riviello, Robert, additional, Robert, Leon L., additional, Rodrigues, Ema G., additional, Rodriguez, Rubens, additional, Ronald, Allan R., additional, Rosenthal, Benjamin M., additional, Rosmarin, David, additional, Ryan, Edward T., additional, Saavedra, Arturo, additional, Schiaffino, Francesca, additional, Schumacher, Sandra K., additional, Sejvar, James J., additional, Sethi, Aisha, additional, Seung, Kwonjune J., additional, Seydel, Karl B., additional, Shah, Melisa M., additional, Shakoor, Sadia, additional, Shankar, Anuraj H., additional, Sharp, Trueman W., additional, Shin, Sonya S., additional, Shirley, Debbie-Ann, additional, Silachamroon, Udomsak, additional, Smith, Catherine C., additional, Snelling, Thomas L., additional, Solomon, Tom, additional, Staat, Mary Allen, additional, Staples, J. Erin, additional, Steiger, Samantha N., additional, Stewart, Robert C., additional, Stich, August, additional, Strickman, Daniel, additional, Suh, Kathryn N., additional, Suhrbier, Andreas, additional, Sutcliffe, Catherine G., additional, Tappe, Dennis, additional, Taylor, Terrie E., additional, Thanh, Nguyen Tat, additional, Thanh, Nguyen Thi, additional, Thwaites, C. Louise, additional, Thwaites, Guy E., additional, Tiwari, Tejpratap S.P., additional, Tsenempi, Xenia A., additional, Turner, Angus W., additional, van den Broek, Nynke R., additional, van Doorn, H. Rogier, additional, Van Sickels, Nicholas J., additional, Vannier, Edouard, additional, Varda, Briony K., additional, Vasconcelos, Pedro F.C., additional, Vega-López, Francisco, additional, Vietri, Nicholas J., additional, Vinetz, Joseph M., additional, Visvesvara, Govinda S., additional, Vyas, Keyur S., additional, Walsh, Thomas J., additional, Wansbrough-Jones, Mark H., additional, Warraich, Haider J., additional, Warrell, David A., additional, Warrell, Mary J., additional, Watt, George, additional, Wattanagoon, Yupaporn, additional, Watthanakulpanich, Dorn, additional, Weaver, Scott C., additional, Weil, Ana A., additional, Weiss, Louis M., additional, White, Nicholas J., additional, Whitty, Christopher J.M., additional, Wilson, Mary E., additional, Xavier, Ramnik J., additional, Xiao, Lihua, additional, Yoon, In-Kyu, additional, Yu, Hongjie, additional, and Zaidi, Anita K.M., additional

Published
2020
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45. Tetanus

Author

Thwaites, Guy E., primary and Thwaites, C. Louise, additional

Published
2020
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48. Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis

Author

Aboderin, Aaron Oladipo, Al-Abri, Seif Salem, Awang Jalil, Nordiah, Benzonana, Nur, Bhattacharya, Sanjay, Brink, Adrian John, Burkert, Francesco Robert, Cars, Otto, Cornaglia, Giuseppe, Dyar, Oliver James, Friedrich, Alex W, Gales, Ana C, Gandra, Sumanth, Giske, Christian Georg, Goff, Debra A, Goossens, Herman, Gottlieb, Thomas, Guzman Blanco, Manuel, Hryniewicz, Waleria, Kattula, Deepthi, Jinks, Timothy, Kanj, Souha S, Kerr, Lawrence, Kieny, Marie-Paule, Kim, Yang Soo, Kozlov, Roman S, Labarca, Jaime, Laxminarayan, Ramanan, Leder, Karin, Leibovici, Leonard, Levy-Hara, Gabriel, Littman, Jasper, Malhotra-Kumar, Surbhi, Manchanda, Vikas, Moja, Lorenzo, Ndoye, Babacar, Pan, Angelo, Paterson, David L, Paul, Mical, Qiu, Haibo, Ramon-Pardo, Pilar, Rodríguez-Baño, Jesús, Sanguinetti, Maurizio, Sengupta, Sharmila, Sharland, Mike, Si-Mehand, Massinissa, Silver, Lynn L, Song, Wonkeung, Steinbakk, Martin, Thomsen, Jens, Thwaites, Guy E, van der Meer, Jos WM, Van Kinh, Nguyen, Vega, Silvio, Villegas, Maria Virginia, Wechsler-Fördös, Agnes, Wertheim, Heiman Frank Louis, Wesangula, Evelyn, Woodford, Neil, Yilmaz, Fidan O, Zorzet, Anna, Tacconelli, Evelina, Carrara, Elena, Savoldi, Alessia, Harbarth, Stephan, Mendelson, Marc, Monnet, Dominique L, Pulcini, Céline, Kahlmeter, Gunnar, Kluytmans, Jan, Carmeli, Yehuda, Ouellette, Marc, Outterson, Kevin, Patel, Jean, Cavaleri, Marco, Cox, Edward M, Houchens, Chris R, Grayson, M Lindsay, Hansen, Paul, Singh, Nalini, Theuretzbacher, Ursula, and Magrini, Nicola

Published
2018
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49. Adjunctive rifampicin for Staphylococcus aureus bacteraemia (ARREST): a multicentre, randomised, double-blind, placebo-controlled trial

Author

Scarborough, Matthew, Kamfose, Musa, de Veciana, Ana, Gordon, Nicola Claire, Peto, Leon, Pill, Gemma, Clarke, Tiphanie, Watson, Laura, Young, Bernadette, Griffiths, Dai, Vaughn, Ali, Anson, Luke, Liu, Elian, Perera, Sanuki, Rylance-Knight, Lydia, Cantell, Carmen, Moroney, Ruth, Edgeworth, Jonathan D, Thwaites, Guy, Bisnauthsing, Karen, Querol-Rubiera, Antonio, Gibbs, Charlotte, Patel, Amita, Hemsley, Carolyn, Goodman, Anna L, Wyncoll, Duncan, Biswas, Jason, Fitzpatrick, Jennifer, Roberts, Lizzie, Millard, James, Stone, Neil, Cape, Angela, Hurley, Lisa, Tam, Chi Kai, Nsutebu, Emmanuel, Hoyle, Marie-Claire, Maitland, Kate, Trainor, Leona, Reynolds, Helen, Harrison, Jennifer, Anson, Jim, Lewis, Joseph, Folb, Jonathan, Goodwin, Lynsey, Beeching, Nicholas, Dyas, Sarah, Winslow, Helen, Foote, Elizabeth, Roberts, Paul, Natarajan, Pavithra, Chrdle, Alex, Fenech, Manuel, Allsop, Hannah, Tilley, Robert, Austin-Hutchison, Rachel, Barrett, Louise, Brookes, Karen, Carwithen, Leanne, Conbeer, Andrew, Cunningham, Richard, Eglinton, Charlotte, Fok, Rosie, Gott, Hannah, Hughes, Shona, Jones, Lewis, Kalita, Maggie, King, Angela, March, Linda, Marner, Mike, Mynes, Tracey, Plant, Aiden, Price, Suzanne, Sercombe, Judy, Stolton, Alison, Wallis, Mark, West, Marie-Claire, Westcott, Jackie, Williams, Claire, Wosley, Rob, Yabsley, Leona, Greig, Julia, Butland, Laura, Sorrell, Julie, Mitchell, Tamara, Alli, Abiola, Meiring, James, Masake, Boingotlo, Rowson, Carlene, Smart, Lynne, Makey, Laura, Moll, Sarah, Cunningham, Jane, Ryalls, Kim, Birchall, Kathryn, Middle, Janet, Jackson, Yvonne, Swift, Diane, Cole, Joby, Subramanian, Bala, Okhuoya, Faith, Edwards, Maria, Bailey, Cheryl, Warren, Rebecca, Islam, Gayti, Ankcorn, Michael, Birchall, Sarah, Jones, Paul, Humphries, John, Booth, Stephen, Evan, Cariad, Wyllie, Sarah, Flatt, Andrew, Strakova, Lenka, Hayes, Maria, Valentine, Stacey, James, Clare, Wands, Mary, Cortes, Nicolas, Khan, Nisa, Porter, Robert, Martin, Zoe, Yip, Keith, Preedy, Helen, Chesterfield, Helen, Dobson, Tracey, Walker, Colin, Llewelyn, Martin, Dunne, Angela, Latter, Laura, Porges, Alison, Price, James, Paul, John, Behar, Laura, Robinson, Louise, Murray, Amy, Sargent, Tenessa, Ridley, Carrie, de Gordoa, Laura Ortiz-Ruiz, Gilliam, Deborah, McPherson, Carole, Matthews, Simon, Foreman, Emma, Jarghese, Rajesh, Beddoe, Alisha, Martin, Sebastien, Shaw, Sephora, Wlazly, Dominika, Cole, Maggie, Gihawi, Abraham, Cole, Kevin, Török, M Estée, Gouliouris, Theodore, Bedford, Luke, Saunderson, Rebecca B, Mariolis, Ilias, Bousfield, Rachel, Ramsay, Isobel, Greaves, Daniel, Aliyu, Sani, Cox, Kim, Mlemba, Lois, Whitehead, Lynne, Vyse, Naval, Bolton, Mark, Williams, John, Lambert, Pauline, Chadwick, David, Baillie, Kirsty, Cain, Martyn, Bellamy, Richard, Wong, Jason, Thompson, Jane, Vassallo, Helen, Skotnicka, Agnieszka, Boyce, Andrea, Donnelly, Anthony, Wilson, Peter, FitzGerald, Graham, Dean, Victoria, Warnes, Kristian, Reyes, Anna, Rahman, Saadia, Tsang, Lillian, Williams, Joanne, Morris-Jones, Stephen, Hopkins, Susan, Witness, Elen, Brady, Orla, Woodford, Elizabeth, Pettifer, Teresa, McCadden, Angela, Marks, Ben, Collier, Sophie, Mack, Damien, Warren, Simon, Brown, Colin, Lyons, Adrian, Taiyari, Sara, Mepham, Stephen, Sweeney, Anna, Brown, Li-An, Auckland, Cressida, Potter, Alison, Mandiza, Jess, Hough, Maxine, Williams, Sue, Renton, Caroline, Walters, Fiona, Nadolski, Maria, Evans, Andree, Tarrant, Polly, Curley, Katherine, Whiteley, Sophie, Halpin, Julia, Hutchings, Melanie, Todd, Shirley, Lohan, Christop, Chapter, Tamika, Folland, Emma, Colville, Alaric, Marden, Katy, Morgan, Marina, Porter, Rob, Baxter, Mel, Minton, Jane, Rippon, Sarah, Cevik, Muge, Chapman, Judith, Kemp, Tim, Vincent, Rachel, Osborne, Dave, Platt, Tracey, Calderwood, James, Cook, Bernadette, Bedford, Caroline, Galloway-Browne, Leanne, Abberley, Nadine, Attack, Kelly, Allen, Joanna, Lal, Pankaj, Harrison, Melanie, Stevenson, Sarah, Brooks, Carol, Harlow, Paula, Ewing, Jordan, Cooper, Shirley, Balancio-Tolentino, Roderick, O'Neil, Laura, Tagney, Rebecca, Shackcloth, Daniela, Planche, Tim, Fellows, James, Millett, Ruth, Studham, Jo, de Souza, Cherrelle, Howell, Geoffrey, Greaves, Hezron, Foncel, Ella, Kurup, Rahul, Briggs, Jack, Smith, Melody, Suarez, Cristina, Sorrentino, Giordana, Scobie, Antonia, Houston, Angela, Ahmad, Fozia, Breathnach, Aodhan, Chahuan, Rakhee, Wilkins, Katie, Guleri, Achyut, Waddington, Natalia, Sharma, Rashmi, Flegg, Peter, Kollipara, Veenu, Alam, Mazhar, Potter, Andrew, Donaldson, Stacey, Armer, Charlote, Frudd, Julie, Jeyaratnam, Dakshika, Joy, Manju, Mathews, Asha, Glass, Stephen K, Ajayi, Ayodele, Fife, Amanda, Qaiser, Saba, Sheehan, Sharon, Muñoz-Villaverde, Sergio, Yogo, Noah, De Abreu, Ines, Notcheva, Gaynor, Flanagan, Joanna, Watson, Cordelia, Sais, Efisia, Adedayo, Adetunji, Chu, Vicky, Shaw, Georgina, Graver, Michelle A, Palmer, Rebecca, Palmer, Donna, Haile, Senait, Gordon, Joanne, Mandar, Kirandip, Szypura, Weronika, Jenkins, Neil, Marange, Josephine, Shabangu, Vusumuzi, Moore, Katy, Lyons, Jill, Munang, Melinda, Sangombe, Mirriam, Moran, Ed, Hussain, Abid, Wiselka, Martin, Lewszuk, Adam, Batham, Sally, Ellis, Kate, Bahadur, Leila, White, Helena, Pareek, Manish, Sahota, Amandip, Coleman, Stephen, Pateman, Hilary, Kotecha, Atul, Sim, Christopher, Rosser, Andrew, Deane, Jill, Nendick, Richard, Aldridge, Catherine, Clarke, Anne, Wood, Michelle, Marshall, Adele, Stephenson, Lynsey, Matheson-Smith, Tracy, Sloss, John, Potts, Kathryn, Malkin, Joanne, Ftika, Lemonia, Raviprakash, Veena, Sutton, Julian, Malachira, Ahalya, Kean, Miranda, Criste, Kristine, Gladas, Kirsty, Andrews, Caroline, Hutchison, Clare, Adams, Ellen, Andrews, Janet, Romans, Belinda, Ridley, Nicola, Ekani, Melanie, Mitchell, Julie, Smith, Nicola, Clark, Tristan, Glover, Sarah, Reed, Robert, Yam, Tat, Burton, Holly, Said, Rasha, Harvey, David, Janvier, Amy, Jacob, Reni, Smalley, Chris, Fair, Alison, Lord, Susan, Ripalda, Kate, Wooldridge, Helen, Cotter, Luis, Cardoso, Gus, Strachan, Elaine, Kaler, Gagan, Mohamoodally, Adam, Lawrence, Emma, Prime, Zoe, Abrahams, Rachel, Price, David Ashley, Rigden, Lesley, Shewan, Laura, Cullen, Katherine, Emmerson, Ingrid, Martin, Karen, Wilson, Hesther, Higham, Charley, Taylor, Kathryn Louise, Ong, Edmund, Patel, Bijal, Bond, Helena, Gradwell, Janine, Widdrington, John, Graham, Clive, Thornthwaite, Sarah, Prentice, Scott, Poultney, Una, Crowther, Hannah, Fairlamb, Helen, Hetherington, Emily, Brewer, Chris, Banerjee, Suryabrata, Hamson, Clare, McSkeane, Anna, McWhinney, Paul, Sharratt, Paula, Thorpe, Joanne, Kimachia, Sue, Wilson, Helen, Jeffs, Benjamin, Masters, Leslie, Wilson, Jonathan, Platt, Judith, Burgess, Lisa, Chadwick, Paul, Jeans, Adam, Keatley, Claire, Moran, Amanda, Swann, Zoe, Pagett, Katherine, Peel, Alex, Howard, Jason, Meisner, Sarah, Maloney, Kate, Masdin, Avril, Wright, Louise, Barlow, Gavin, Crossman, Samantha, Lowthorpe, Vicki, Moore, Emma, Moss, Peter, Parkin, Angela, Wolstencroft, Adam, Warner, Bev, Tarbotton, Clare, Eyre, Alison, Anderson, Anne, Burdett, Tina, Driffill, Amy, Walker, Ann Sarah, Hudson, Fleur, Szubert, Alex, Cairns, Janet, Ward, Denise, Webb, Helen, Russell, Charlotte, Jackson, Brooke, Otiko, Damilola, Borg, Chiara, Masters, Lindsey, Islam, Zaheer, Díaz-Montaña, Carlos, Johnson, Debbie, Thwaites, Guy E, Szubert, Alexander, Wyllie, Sarah A, Armando, Gonzalez-Ruiz, Chadwick, Paul R, Gordon, N Claire, Price, David A, Nayar, Deepa, Török, M Estee, Llewelyn, Martin J, and Walker, A Sarah

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2018
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