13 results on '"Thuy-Nhien, Nguyen Thanh"'
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2. Evolution and expansion of multidrug-resistant malaria in southeast Asia: a genomic epidemiology study
- Author
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Hamilton, William L, Amato, Roberto, van der Pluijm, Rob W, Jacob, Christopher G, Quang, Huynh Hong, Thuy-Nhien, Nguyen Thanh, Hien, Tran Tinh, Hongvanthong, Bouasy, Chindavongsa, Keobouphaphone, Mayxay, Mayfong, Huy, Rekol, Leang, Rithea, Huch, Cheah, Dysoley, Lek, Amaratunga, Chanaki, Suon, Seila, Fairhurst, Rick M, Tripura, Rupam, Peto, Thomas J, Sovann, Yok, Jittamala, Podjanee, Hanboonkunupakarn, Borimas, Pukrittayakamee, Sasithon, Chau, Nguyen Hoang, Imwong, Mallika, Dhorda, Mehul, Vongpromek, Ranitha, Chan, Xin Hui S, Maude, Richard J, Pearson, Richard D, Nguyen, T, Rockett, Kirk, Drury, Eleanor, Gonçalves, Sónia, White, Nicholas J, Day, Nicholas P, Kwiatkowski, Dominic P, Dondorp, Arjen M, and Miotto, Olivo
- Published
- 2019
- Full Text
- View/download PDF
3. Evolution of Multidrug Resistance in Plasmodium falciparum: a Longitudinal Study of Genetic Resistance Markers in the Greater Mekong Subregion
- Author
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Imwong, Mallika, primary, Suwannasin, Kanokon, additional, Srisutham, Suttipat, additional, Vongpromek, Ranitha, additional, Promnarate, Cholrawee, additional, Saejeng, Aungkana, additional, Phyo, Aung Pyae, additional, Proux, Stephane, additional, Pongvongsa, Tiengkham, additional, Chea, Nguon, additional, Miotto, Olivo, additional, Tripura, Rupam, additional, Nguyen Hoang, Chau, additional, Dysoley, Lek, additional, Ho Dang Trung, Nghia, additional, Peto, Thomas J., additional, Callery, James J., additional, van der Pluijm, Rob W., additional, Amaratunga, Chanaki, additional, Mukaka, Mavuto, additional, von Seidlein, Lorenz, additional, Mayxay, Mayfong, additional, Thuy-Nhien, Nguyen Thanh, additional, Newton, Paul N., additional, Day, Nicholas P. J., additional, Ashley, Elizabeth A., additional, Nosten, Francois H., additional, Smithuis, Frank M., additional, Dhorda, Mehul, additional, White, Nicholas J., additional, and Dondorp, Arjen M., additional
- Published
- 2021
- Full Text
- View/download PDF
4. Spread of Artemisinin Resistance in Plasmodium falciparum Malaria
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Ashley, Elizabeth A., Dhorda, Mehul, Fairhurst, Rick M., Amaratunga, Chanaki, Lim, Parath, Suon, Seila, Sreng, Sokunthea, Anderson, Jennifer M., Mao, Sivanna, Sam, Baramey, Sopha, Chantha, Chuor, Char Meng, Nguon, Chea, Sovannaroth, Siv, Pukrittayakamee, Sasithon, Jittamala, Podjanee, Chotivanich, Kesinee, Chutasmit, Kitipumi, Suchatsoonthorn, Chaiyaporn, Runcharoen, Ratchadaporn, Hien, Tran Tinh, Thuy-Nhien, Nguyen Thanh, Thanh, Ngo Viet, Phu, Nguyen Hoan, Htut, Ye, Han, Kay-Thwe, Aye, Kyin Hla, Mokuolu, Olugbenga A., Olaosebikan, Rasaq R., Folaranmi, Olaleke O., Mayxay, Mayfong, Khanthavong, Maniphone, Hongvanthong, Bouasy, Newton, Paul N., Onyamboko, Marie A., Fanello, Caterina I., Tshefu, Antoinette K., Mishra, Neelima, Valecha, Neena, Phyo, Aung Pyae, Nosten, Francois, Yi, Poravuth, Tripura, Rupam, Borrmann, Steffen, Bashraheil, Mahfudh, Peshu, Judy, Faiz, M. Abul, Ghose, Aniruddha, Hossain, M. Amir, Samad, Rasheda, Rahman, M. Ridwanur, Hasan, M. Mahtabuddin, Islam, Akhterul, Miotto, Olivo, Amato, Roberto, MacInnis, Bronwyn, Stalker, Jim, Kwiatkowski, Dominic P., Bozdech, Zbynek, Jeeyapant, Atthanee, Cheah, Phaik Yeong, Sakulthaew, Tharisara, Chalk, Jeremy, Intharabut, Benjamas, Silamut, Kamolrat, Lee, Sue J., Vihokhern, Benchawan, Kunasol, Chanon, Imwong, Mallika, Tarning, Joel, Taylor, Walter J., Yeung, Shunmay, Woodrow, Charles J., Flegg, Jennifer A., Das, Debashish, Smith, Jeffery, Venkatesan, Meera, Plowe, Christopher V., Stepniewska, Kasia, Guerin, Philippe J., Dondorp, Arjen M., Day, Nicholas P., and White, Nicholas J.
- Published
- 2014
- Full Text
- View/download PDF
5. The mechanism of artemisinin resistance of Plasmodium falciparum malaria parasites originates in their initial transcriptional response.
- Author
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Zhu, Lei, primary, Pluijm, Rob W. van der, additional, Kucharski, Michal, additional, Nayak, Sourav, additional, Tripathi, Jaishree, additional, Nosten, François, additional, Faiz, Abul, additional, Amaratunga, Chanak, additional, Lek, Dysoley, additional, Ashley, Elizabeth A, additional, Smithuis, Frank, additional, Phyo, Aung Pyae, additional, Lin, Khin, additional, Imwong, Mallika, additional, Mayxay, Mayfong, additional, Dhorda, Mehul, additional, Chau, Nguyen Hoang, additional, Thuy, Nhien Nguyen Thanh Thuy, additional, Newton, Paul N, additional, Jittamala, Podjanee, additional, Tripura, Rupam, additional, Pukrittayakamee, Sasithon, additional, Peto, Thomas J, additional, Miotto, Olivo, additional, von Seidlein, Lorenz, additional, Hien, Tran Tinh, additional, Ginsburg, Hagai, additional, Day, Nicholas PJ, additional, White, Nicholas J., additional, Dondorp, Arjen M, additional, and Bozdech, Zbynek, additional
- Published
- 2021
- Full Text
- View/download PDF
6. Triple artemisinin-based combination therapies versus artemisinin-based combination therapies for uncomplicated Plasmodium falciparum malaria: a multicentre, open-label, randomised clinical trial
- Author
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van der Pluijm, Rob W, primary, Tripura, Rupam, additional, Hoglund, Richard M, additional, Pyae Phyo, Aung, additional, Lek, Dysoley, additional, ul Islam, Akhter, additional, Anvikar, Anupkumar R, additional, Satpathi, Parthasarathi, additional, Satpathi, Sanghamitra, additional, Behera, Prativa Kumari, additional, Tripura, Amar, additional, Baidya, Subrata, additional, Onyamboko, Marie, additional, Chau, Nguyen Hoang, additional, Sovann, Yok, additional, Suon, Seila, additional, Sreng, Sokunthea, additional, Mao, Sivanna, additional, Oun, Savuth, additional, Yen, Sovannary, additional, Amaratunga, Chanaki, additional, Chutasmit, Kitipumi, additional, Saelow, Chalermpon, additional, Runcharern, Ratchadaporn, additional, Kaewmok, Weerayuth, additional, Hoa, Nhu Thi, additional, Thanh, Ngo Viet, additional, Hanboonkunupakarn, Borimas, additional, Callery, James J, additional, Mohanty, Akshaya Kumar, additional, Heaton, James, additional, Thant, Myo, additional, Gantait, Kripasindhu, additional, Ghosh, Tarapada, additional, Amato, Roberto, additional, Pearson, Richard D, additional, Jacob, Christopher G, additional, Gonçalves, Sónia, additional, Mukaka, Mavuto, additional, Waithira, Naomi, additional, Woodrow, Charles J, additional, Grobusch, Martin P, additional, van Vugt, Michele, additional, Fairhurst, Rick M, additional, Cheah, Phaik Yeong, additional, Peto, Thomas J, additional, von Seidlein, Lorenz, additional, Dhorda, Mehul, additional, Maude, Richard J, additional, Winterberg, Markus, additional, Thuy-Nhien, Nguyen Thanh, additional, Kwiatkowski, Dominic P, additional, Imwong, Mallika, additional, Jittamala, Podjanee, additional, Lin, Khin, additional, Hlaing, Tin Maung, additional, Chotivanich, Kesinee, additional, Huy, Rekol, additional, Fanello, Caterina, additional, Ashley, Elizabeth, additional, Mayxay, Mayfong, additional, Newton, Paul N, additional, Hien, Tran Tinh, additional, Valecha, Neena, additional, Smithuis, Frank, additional, Pukrittayakamee, Sasithon, additional, Faiz, Abul, additional, Miotto, Olivo, additional, Tarning, Joel, additional, Day, Nicholas P J, additional, White, Nicholas J, additional, Dondorp, Arjen M, additional, van der Pluijm, Rob W, additional, Phyo, Aung Pyae, additional, Thuy-Nhien, Nguyen T, additional, Valeche, Neena, additional, and Day, Nicholas PJ, additional
- Published
- 2020
- Full Text
- View/download PDF
7. Evolution and expansion of multidrug resistant malaria in Southeast Asia: a genomic epidemiology study
- Author
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Hamilton, William L, primary, Amato, Roberto, additional, van der Pluijm, Rob W, additional, Jacob, Christopher G, additional, Quang, Huynh Hong, additional, Thuy-Nhien, Nguyen Thanh, additional, Hien, Tran Tinh, additional, Hongvanthong, Bouasy, additional, Chindavongsa, Keobouphaphone, additional, Mayxay, Mayfong, additional, Rekol, Huy, additional, Leang, Rithea, additional, Huch, Cheah, additional, Dysoley, Lek, additional, Amaratunga, Chanaki, additional, Suon, Seila, additional, Fairhurst, Rick M, additional, Tripura, Rupam, additional, Peto, Thomas J, additional, Sovann, Yok, additional, Jittamala, Podjanee, additional, Hanboonkunupakarn, Borimas, additional, Pukrittayakamee, Sasithon, additional, Chau, Nguyen Hoang, additional, Imwong, Mallika, additional, Dhorda, Mehul, additional, Vongpromek, Ranitha, additional, Chan, Xin Hui S, additional, Maude, Richard J, additional, Pearson, Richard D, additional, Nguyen, T, additional, Rockett, Kirk, additional, Drury, Eleanor, additional, Gonçalves, Sonia, additional, White, Nicholas J, additional, Day, Nicholas P, additional, Kwiatkowski, Dominic P, additional, Dondorp, Arjen M, additional, and Miotto, Olivo, additional
- Published
- 2019
- Full Text
- View/download PDF
8. Estimation of the In Vivo MIC of Cipargamin in Uncomplicated Plasmodium falciparum Malaria
- Author
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Hien, Tran Tinh, primary, White, Nicholas J., additional, Thuy-Nhien, Nguyen Thanh, additional, Hoa, Nhu Thi, additional, Thuan, Phung Duc, additional, Tarning, Joel, additional, Nosten, François, additional, Magnusson, Baldur, additional, Jain, Jay Prakash, additional, and Hamed, Kamal, additional
- Published
- 2017
- Full Text
- View/download PDF
9. Triple artemisinin-based combination therapies versus artemisinin-based combination therapies for uncomplicated Plasmodium falciparummalaria: a multicentre, open-label, randomised clinical trial
- Author
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van der Pluijm, Rob W, Tripura, Rupam, Hoglund, Richard M, Pyae Phyo, Aung, Lek, Dysoley, ul Islam, Akhter, Anvikar, Anupkumar R, Satpathi, Parthasarathi, Satpathi, Sanghamitra, Behera, Prativa Kumari, Tripura, Amar, Baidya, Subrata, Onyamboko, Marie, Chau, Nguyen Hoang, Sovann, Yok, Suon, Seila, Sreng, Sokunthea, Mao, Sivanna, Oun, Savuth, Yen, Sovannary, Amaratunga, Chanaki, Chutasmit, Kitipumi, Saelow, Chalermpon, Runcharern, Ratchadaporn, Kaewmok, Weerayuth, Hoa, Nhu Thi, Thanh, Ngo Viet, Hanboonkunupakarn, Borimas, Callery, James J, Mohanty, Akshaya Kumar, Heaton, James, Thant, Myo, Gantait, Kripasindhu, Ghosh, Tarapada, Amato, Roberto, Pearson, Richard D, Jacob, Christopher G, Gonçalves, Sónia, Mukaka, Mavuto, Waithira, Naomi, Woodrow, Charles J, Grobusch, Martin P, van Vugt, Michele, Fairhurst, Rick M, Cheah, Phaik Yeong, Peto, Thomas J, von Seidlein, Lorenz, Dhorda, Mehul, Maude, Richard J, Winterberg, Markus, Thuy-Nhien, Nguyen Thanh, Kwiatkowski, Dominic P, Imwong, Mallika, Jittamala, Podjanee, Lin, Khin, Hlaing, Tin Maung, Chotivanich, Kesinee, Huy, Rekol, Fanello, Caterina, Ashley, Elizabeth, Mayxay, Mayfong, Newton, Paul N, Hien, Tran Tinh, Valecha, Neena, Smithuis, Frank, Pukrittayakamee, Sasithon, Faiz, Abul, Miotto, Olivo, Tarning, Joel, Day, Nicholas P J, White, Nicholas J, Dondorp, Arjen M, van der Pluijm, Rob W, Tripura, Rupam, Hoglund, Richard M, Phyo, Aung Pyae, Lek, Dysoley, ul Islam, Akhter, Anvikar, Anupkumar R, Satpathi, Parthasarathi, Satpathi, Sanghamitra, Behera, Prativa Kumari, Tripura, Amar, Baidya, Subrata, Onyamboko, Marie, Chau, Nguyen Hoang, Sovann, Yok, Suon, Seila, Sreng, Sokunthea, Mao, Sivanna, Oun, Savuth, Yen, Sovannary, Amaratunga, Chanaki, Chutasmit, Kitipumi, Saelow, Chalermpon, Runcharern, Ratchadaporn, Kaewmok, Weerayuth, Hoa, Nhu Thi, Thanh, Ngo Viet, Hanboonkunupakarn, Borimas, Callery, James J, Mohanty, Akshaya Kumar, Heaton, James, Thant, Myo, Gantait, Kripasindhu, Ghosh, Tarapada, Amato, Roberto, Pearson, Richard D, Jacob, Christopher G, Gonçalves, Sónia, Mukaka, Mavuto, Waithira, Naomi, Woodrow, Charles J, Grobusch, Martin P, van Vugt, Michele, Fairhurst, Rick M, Cheah, Phaik Yeong, Peto, Thomas J, von Seidlein, Lorenz, Dhorda, Mehul, Maude, Richard J, Winterberg, Markus, Thuy-Nhien, Nguyen T, Kwiatkowski, Dominic P, Imwong, Mallika, Jittamala, Podjanee, Lin, Khin, Hlaing, Tin Maung, Chotivanich, Kesinee, Huy, Rekol, Fanello, Caterina, Ashley, Elizabeth, Mayxay, Mayfong, Newton, Paul N, Hien, Tran Tinh, Valeche, Neena, Smithuis, Frank, Pukrittayakamee, Sasithon, Faiz, Abul, Miotto, Olivo, Tarning, Joel, Day, Nicholas PJ, White, Nicholas J, and Dondorp, Arjen M
- Abstract
Artemisinin and partner-drug resistance in Plasmodium falciparumare major threats to malaria control and elimination. Triple artemisinin-based combination therapies (TACTs), which combine existing co-formulated ACTs with a second partner drug that is slowly eliminated, might provide effective treatment and delay emergence of antimalarial drug resistance.
- Published
- 2020
- Full Text
- View/download PDF
10. In vivo susceptibility of Plasmodium falciparum to artesunate in Binh Phuoc Province, Vietnam
- Author
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Hien, Tran Tinh, primary, Thuy-Nhien, Nguyen Thanh, additional, Phu, Nguyen Hoan, additional, Boni, Maciej F, additional, Thanh, Ngo Viet, additional, Nha-Ca, Nguyen Thuy, additional, Thai, Le Hong, additional, Thai, Cao Quang, additional, Van Toi, Pham, additional, Thuan, Phung Duc, additional, Long, Le Thanh, additional, Dong, Le Thanh, additional, Merson, Laura, additional, Dolecek, Christiane, additional, Stepniewska, Kasia, additional, Ringwald, Pascal, additional, White, Nicholas J, additional, Farrar, Jeremy, additional, and Wolbers, Marcel, additional
- Published
- 2012
- Full Text
- View/download PDF
11. Triple artemisinin-based combination therapies versus artemisinin-based combination therapies for uncomplicated Plasmodium falciparum malaria: a multicentre, open-label, randomised clinical trial.
- Author
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van der Pluijm, Rob W, Tripura, Rupam, Hoglund, Richard M, Pyae Phyo, Aung, Lek, Dysoley, Ul Islam, Akhter, Anvikar, Anupkumar R, Satpathi, Parthasarathi, Satpathi, Sanghamitra, Behera, Prativa Kumari, Tripura, Amar, Baidya, Subrata, Onyamboko, Marie, Chau, Nguyen Hoang, Sovann, Yok, Suon, Seila, Sreng, Sokunthea, Mao, Sivanna, Oun, Savuth, Yen, Sovannary, Amaratunga, Chanaki, Chutasmit, Kitipumi, Saelow, Chalermpon, Runcharern, Ratchadaporn, Kaewmok, Weerayuth, Hoa, Nhu Thi, Thanh, Ngo Viet, Hanboonkunupakarn, Borimas, Callery, James J, Mohanty, Akshaya Kumar, Heaton, James, Thant, Myo, Gantait, Kripasindhu, Ghosh, Tarapada, Amato, Roberto, Pearson, Richard D, Jacob, Christopher G, Gonçalves, Sónia, Mukaka, Mavuto, Waithira, Naomi, Woodrow, Charles J, Grobusch, Martin P, van Vugt, Michele, Fairhurst, Rick M, Cheah, Phaik Yeong, Peto, Thomas J, von Seidlein, Lorenz, Dhorda, Mehul, Maude, Richard J, Winterberg, Markus, Thuy-Nhien, Nguyen Thanh, Kwiatkowski, Dominic P, Imwong, Mallika, Jittamala, Podjanee, Lin, Khin, Hlaing, Tin Maung, Chotivanich, Kesinee, Huy, Rekol, Fanello, Caterina, Ashley, Elizabeth, Mayxay, Mayfong, Newton, Paul N, Hien, Tran Tinh, Valecha, Neena, Smithuis, Frank, Pukrittayakamee, Sasithon, Faiz, Abul, Miotto, Olivo, Tarning, Joel, Day, Nicholas P J, White, Nicholas J, Dondorp, Arjen M, van der Pluijm, Rob W, Tripura, Rupam, Hoglund, Richard M, Pyae Phyo, Aung, Lek, Dysoley, Ul Islam, Akhter, Anvikar, Anupkumar R, Satpathi, Parthasarathi, Satpathi, Sanghamitra, Behera, Prativa Kumari, Tripura, Amar, Baidya, Subrata, Onyamboko, Marie, Chau, Nguyen Hoang, Sovann, Yok, Suon, Seila, Sreng, Sokunthea, Mao, Sivanna, Oun, Savuth, Yen, Sovannary, Amaratunga, Chanaki, Chutasmit, Kitipumi, Saelow, Chalermpon, Runcharern, Ratchadaporn, Kaewmok, Weerayuth, Hoa, Nhu Thi, Thanh, Ngo Viet, Hanboonkunupakarn, Borimas, Callery, James J, Mohanty, Akshaya Kumar, Heaton, James, Thant, Myo, Gantait, Kripasindhu, Ghosh, Tarapada, Amato, Roberto, Pearson, Richard D, Jacob, Christopher G, Gonçalves, Sónia, Mukaka, Mavuto, Waithira, Naomi, Woodrow, Charles J, Grobusch, Martin P, van Vugt, Michele, Fairhurst, Rick M, Cheah, Phaik Yeong, Peto, Thomas J, von Seidlein, Lorenz, Dhorda, Mehul, Maude, Richard J, Winterberg, Markus, Thuy-Nhien, Nguyen Thanh, Kwiatkowski, Dominic P, Imwong, Mallika, Jittamala, Podjanee, Lin, Khin, Hlaing, Tin Maung, Chotivanich, Kesinee, Huy, Rekol, Fanello, Caterina, Ashley, Elizabeth, Mayxay, Mayfong, Newton, Paul N, Hien, Tran Tinh, Valecha, Neena, Smithuis, Frank, Pukrittayakamee, Sasithon, Faiz, Abul, Miotto, Olivo, Tarning, Joel, Day, Nicholas P J, White, Nicholas J, and Dondorp, Arjen M
- Abstract
Background:Artemisinin and partner-drug resistance in Plasmodium falciparum are major threats to malaria control and elimination. Triple artemisinin-based combination therapies (TACTs), which combine existing co-formulated ACTs with a second partner drug that is slowly eliminated, might provide effective treatment and delay emergence of antimalarial drug resistance. Methods: In this multicentre, open-label, randomised trial, we recruited patients with uncomplicated P falciparum malaria at 18 hospitals and health clinics in eight countries. Eligible patients were aged 2-65 years, with acute, uncomplicated P falciparum malaria alone or mixed with non-falciparum species, and a temperature of 37·5°C or higher, or a history of fever in the past 24 h. Patients were randomly assigned (1:1) to one of two treatments using block randomisation, depending on their location: in Thailand, Cambodia, Vietnam, and Myanmar patients were assigned to either dihydroartemisinin-piperaquine or dihydroartemisinin-piperaquine plus mefloquine; at three sites in Cambodia they were assigned to either artesunate-mefloquine or dihydroartemisinin-piperaquine plus mefloquine; and in Laos, Myanmar, Bangladesh, India, and the Democratic Republic of the Congo they were assigned to either artemether-lumefantrine or artemether-lumefantrine plus amodiaquine. All drugs were administered orally and doses varied by drug combination and site. Patients were followed-up weekly for 42 days. The primary endpoint was efficacy, defined by 42-day PCR-corrected adequate clinical and parasitological response. Primary analysis was by intention to treat. A detailed assessment of safety and tolerability of the study drugs was done in all patients randomly assigned to treatment. This study is registered at ClinicalTrials.gov, NCT02453308, and is complete. Findings: Between Aug 7, 2015, and Feb 8, 2018, 1100 patients were given either dihydroartemisinin-piperaqui
12. Triple artemisinin-based combination therapies versus artemisinin-based combination therapies for uncomplicated Plasmodium falciparum malaria: a multicentre, open-label, randomised clinical trial.
- Author
-
van der Pluijm, Rob W, Tripura, Rupam, Hoglund, Richard M, Pyae Phyo, Aung, Lek, Dysoley, Ul Islam, Akhter, Anvikar, Anupkumar R, Satpathi, Parthasarathi, Satpathi, Sanghamitra, Behera, Prativa Kumari, Tripura, Amar, Baidya, Subrata, Onyamboko, Marie, Chau, Nguyen Hoang, Sovann, Yok, Suon, Seila, Sreng, Sokunthea, Mao, Sivanna, Oun, Savuth, Yen, Sovannary, Amaratunga, Chanaki, Chutasmit, Kitipumi, Saelow, Chalermpon, Runcharern, Ratchadaporn, Kaewmok, Weerayuth, Hoa, Nhu Thi, Thanh, Ngo Viet, Hanboonkunupakarn, Borimas, Callery, James J, Mohanty, Akshaya Kumar, Heaton, James, Thant, Myo, Gantait, Kripasindhu, Ghosh, Tarapada, Amato, Roberto, Pearson, Richard D, Jacob, Christopher G, Gonçalves, Sónia, Mukaka, Mavuto, Waithira, Naomi, Woodrow, Charles J, Grobusch, Martin P, van Vugt, Michele, Fairhurst, Rick M, Cheah, Phaik Yeong, Peto, Thomas J, von Seidlein, Lorenz, Dhorda, Mehul, Maude, Richard J, Winterberg, Markus, Thuy-Nhien, Nguyen Thanh, Kwiatkowski, Dominic P, Imwong, Mallika, Jittamala, Podjanee, Lin, Khin, Hlaing, Tin Maung, Chotivanich, Kesinee, Huy, Rekol, Fanello, Caterina, Ashley, Elizabeth, Mayxay, Mayfong, Newton, Paul N, Hien, Tran Tinh, Valecha, Neena, Smithuis, Frank, Pukrittayakamee, Sasithon, Faiz, Abul, Miotto, Olivo, Tarning, Joel, Day, Nicholas P J, White, Nicholas J, Dondorp, Arjen M, van der Pluijm, Rob W, Tripura, Rupam, Hoglund, Richard M, Pyae Phyo, Aung, Lek, Dysoley, Ul Islam, Akhter, Anvikar, Anupkumar R, Satpathi, Parthasarathi, Satpathi, Sanghamitra, Behera, Prativa Kumari, Tripura, Amar, Baidya, Subrata, Onyamboko, Marie, Chau, Nguyen Hoang, Sovann, Yok, Suon, Seila, Sreng, Sokunthea, Mao, Sivanna, Oun, Savuth, Yen, Sovannary, Amaratunga, Chanaki, Chutasmit, Kitipumi, Saelow, Chalermpon, Runcharern, Ratchadaporn, Kaewmok, Weerayuth, Hoa, Nhu Thi, Thanh, Ngo Viet, Hanboonkunupakarn, Borimas, Callery, James J, Mohanty, Akshaya Kumar, Heaton, James, Thant, Myo, Gantait, Kripasindhu, Ghosh, Tarapada, Amato, Roberto, Pearson, Richard D, Jacob, Christopher G, Gonçalves, Sónia, Mukaka, Mavuto, Waithira, Naomi, Woodrow, Charles J, Grobusch, Martin P, van Vugt, Michele, Fairhurst, Rick M, Cheah, Phaik Yeong, Peto, Thomas J, von Seidlein, Lorenz, Dhorda, Mehul, Maude, Richard J, Winterberg, Markus, Thuy-Nhien, Nguyen Thanh, Kwiatkowski, Dominic P, Imwong, Mallika, Jittamala, Podjanee, Lin, Khin, Hlaing, Tin Maung, Chotivanich, Kesinee, Huy, Rekol, Fanello, Caterina, Ashley, Elizabeth, Mayxay, Mayfong, Newton, Paul N, Hien, Tran Tinh, Valecha, Neena, Smithuis, Frank, Pukrittayakamee, Sasithon, Faiz, Abul, Miotto, Olivo, Tarning, Joel, Day, Nicholas P J, White, Nicholas J, and Dondorp, Arjen M
- Abstract
Background:Artemisinin and partner-drug resistance in Plasmodium falciparum are major threats to malaria control and elimination. Triple artemisinin-based combination therapies (TACTs), which combine existing co-formulated ACTs with a second partner drug that is slowly eliminated, might provide effective treatment and delay emergence of antimalarial drug resistance. Methods: In this multicentre, open-label, randomised trial, we recruited patients with uncomplicated P falciparum malaria at 18 hospitals and health clinics in eight countries. Eligible patients were aged 2-65 years, with acute, uncomplicated P falciparum malaria alone or mixed with non-falciparum species, and a temperature of 37·5°C or higher, or a history of fever in the past 24 h. Patients were randomly assigned (1:1) to one of two treatments using block randomisation, depending on their location: in Thailand, Cambodia, Vietnam, and Myanmar patients were assigned to either dihydroartemisinin-piperaquine or dihydroartemisinin-piperaquine plus mefloquine; at three sites in Cambodia they were assigned to either artesunate-mefloquine or dihydroartemisinin-piperaquine plus mefloquine; and in Laos, Myanmar, Bangladesh, India, and the Democratic Republic of the Congo they were assigned to either artemether-lumefantrine or artemether-lumefantrine plus amodiaquine. All drugs were administered orally and doses varied by drug combination and site. Patients were followed-up weekly for 42 days. The primary endpoint was efficacy, defined by 42-day PCR-corrected adequate clinical and parasitological response. Primary analysis was by intention to treat. A detailed assessment of safety and tolerability of the study drugs was done in all patients randomly assigned to treatment. This study is registered at ClinicalTrials.gov, NCT02453308, and is complete. Findings: Between Aug 7, 2015, and Feb 8, 2018, 1100 patients were given either dihydroartemisinin-piperaqui
13. Estimation of the In VivoMIC of Cipargamin in Uncomplicated Plasmodium falciparumMalaria
- Author
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Hien, Tran Tinh, White, Nicholas J., Thuy-Nhien, Nguyen Thanh, Hoa, Nhu Thi, Thuan, Phung Duc, Tarning, Joel, Nosten, François, Magnusson, Baldur, Jain, Jay Prakash, and Hamed, Kamal
- Abstract
ABSTRACTThe MIC of an antimalarial drug for a particular infection is the drug level associated with a net parasite multiplication rate of one per asexual cycle. To ensure the cure of malaria, the MIC must be exceeded until all parasites have been eliminated. The development of highly sensitive and accurate PCR quantitation of low-density malaria parasitemia enables the prospective pharmacokinetic-pharmacodynamic (PK-PD) characterization of antimalarial drug effects and now allows identification of the in vivoMIC. An adaptive design and a PK-PD modeling approach were used to determine prospectively the MIC of the new antimalarial cipargamin (KAE609) in adults with uncomplicated Plasmodium falciparummalaria in an open-label, dose-ranging phase 2a study. Vietnamese adults with acute P. falciparummalaria were allocated sequentially to treatment with a single 30-mg (n= 6), 20-mg (n= 5), 10-mg (n= 7), or 15-mg (n= 7) dose of cipargamin. Artemisinin-based combination therapy was given after parasite densities had fallen and then risen as cipargamin levels declined below the MIC but before a return of signs or symptoms. The rates of parasite clearance were dose dependent, with near saturation of the effect being seen at an adult dose of 30 mg. The developed PK-PD model accurately predicted the therapeutic responses in 23/25 patients. The predicted median in vivoMIC was 0.126 ng/ml (range, 0.038 to 0.803 ng/ml). Pharmacometric characterization of the relationship between antimalarial drug concentrations and parasite clearance rates following graded subtherapeutic antimalarial drug dosing is safe and provides a rational framework for dose finding in antimalarial drug development. (This study has been registered at ClinicalTrials.gov under identifier NCT01836458.)
- Published
- 2016
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