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1. Immunogenicity of Abdala COVID-19 vaccine in Vietnamese people after primary and booster vaccinations: A prospective observational study in Vietnam

Author

Thanh, Tran Tan, Tu, Nguyen Thi Kha, Nguyet, Lam Anh, Thuy, Cao Thu, Thuan, Nguyen Lam Thai, Ny, Nguyen Thi Han, Nhu, Le Nguyen Truc, Thanh, Le Kim, Hong, Nguyen Thi Thu, Anh, Nguyen To, Truong, Nguyen Thanh, Chau, Nguyen Van Vinh, Yen, Lam Minh, Van E, Phan, Thuong, Nguyen Phong, Van Truc, Nguyen, Trung, Pham Huu, Yap, Wee Chee, Pandey, Rahul, Yee, Sidney, Weng, Ruifen, Mongkolsapaya, Juthathip, Dejnirattisai, Wanwisa, Hamers, Raph L, Chantratita, Narisara, Screaton, Gavin, Dunachie, Susanna J, Jones, E Yvonne, Stuart, David I, Dung, Nguyen Thanh, Thwaites, Guy, Wang, Lin-Fa, Tan, Chee Wah, and Tan, Le Van

Published
2024
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2. Charting the path forward in Southeast Asia: Learning from the COVID-19 vaccination challenges in six ASEAN countries

Author

Fu, Jolene Yin Ling, primary, Pukhari, Muhammad Harith, additional, Dela Cruz, Kristine Alvarado, additional, Soebandrio, Amin, additional, Tan, Le Van, additional, Jantarabenjakul, Watsamon, additional, Sawitri, Anak Agung Sagung, additional, Chantasrisawad, Napaporn, additional, Yee, Sidney, additional, Weng, Ruifen, additional, Sundar, Raghav, additional, Tan, Chee Wah, additional, Wang, Lin-Fa, additional, Sam, I-Ching, additional, Young, Barnaby, additional, Sutarsa, I Nyoman, additional, Chan, Yoke Fun, additional, Putcharoen, Opass, additional, Wacharapluesadee, Supaporn, additional, Syed Omar, Sharifah Faridah, additional, Rajasuriar, Reena, additional, Kukreja, Anjanna, additional, Basri, Sazali, additional, Kamarulzaman, Adeeba, additional, Tan, Cheng Siang, additional, Said, Asri, additional, Su’ut, Lela, additional, Tu, Nguyen Thi Kha, additional, Thuy, Cao Thu, additional, Nguyet, Lam Anh, additional, Thanh, Le Kim, additional, Ny, Nguyen Thi Han, additional, Hong, Nguyen Thi Thu, additional, Nhu, Le Nguyen Truc, additional, Thanh, Tran Tan, additional, Truong, Nguyen Thanh, additional, Ho, Yuan Lu, additional, Pandey, Rahul, additional, Diong, Shiau Hui, additional, Libau, Eshele Anak, additional, Ongko, Juwinda, additional, Lim, Jonathan, additional, Abdullah, Ridzwan, additional, Yeo, He Ping, additional, Chin, Yi Qing, additional, Jin, Jocelyn Yu, additional, Lim, Beng Lee, additional, Zhu, Feng, additional, Chee, Yap Wee, additional, Lumandas, Mayan U, additional, Dizon, Timothy John R, additional, Demetria, Catalino S, additional, Biocarles, Mary Glazel N, additional, Inobaya, Marianette T, additional, Sornillo, Johanna Beulah T, additional, Morin, Jonjee C, additional, Digman, Arjay Niño A, additional, Roxas, Celine Bernice A, additional, Jiz, Mario Antonio L, additional, Pinatih, Komang Januartha Putra, additional, Yuliyatni, Putu Cintya Denny, additional, Manuaba, Ida Bagus Jelantik, additional, Wisnawa, I Nyoman Dharma, additional, Kusmawati, Amy Yelly, additional, and Rissa Cempaka, Pande Putu Ayu, additional

Published
2024
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3. Seroprotection against tetanus in southern Vietnam

Author

Thwaites, C. Louise, primary, Thanh, Tran Tan, additional, Ny, Nguyen Thi Han, additional, Nguyet, Lam Anh, additional, Nhat, Nguyen Thi Duy, additional, Thuy, Cao Thu, additional, Thanh, Nguyen Thi Le, additional, Dung, Nguyen Thanh, additional, Campbell, James, additional, Thai, Pham Quang, additional, Tan, Le Van, additional, Choisy, Marc, additional, and Boni, Maciej F., additional

Published
2023
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4. Kinetics of Neutralizing Antibodies against Omicron Variant in Vietnamese Healthcare Workers after Primary Immunization with ChAdOx1-S and Booster Immunization with BNT162b2

Author

Chau, Nguyen Van Vinh, primary, Nguyet, Lam Anh, additional, Dung, Nguyen Thanh, additional, Quang, Vo Minh, additional, Truong, Nguyen Thanh, additional, Toan, Le Mau, additional, Hung, Le Manh, additional, Man, Dinh Nguyen Huy, additional, Khoa, Dao Bach, additional, Phong, Nguyen Thanh, additional, Ngoc, Nghiem My, additional, Thao, Huynh Phuong, additional, Ty, Dinh Thi Bich, additional, Thanh, Pham Ba, additional, Ny, Nguyen Thi Han, additional, Thanh, Le Kim, additional, Thuy, Cao Thu, additional, Anh, Nguyen To, additional, Hong, Nguyen Thi Thu, additional, Nhu, Le Nguyen Truc, additional, Yen, Lam Minh, additional, Thwaites, Guy, additional, Thanh, Tran Tan, additional, Tan, Le Van, additional, and _, _, additional

Published
2023
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5. The dynamics of GII.4 Norovirus in Ho Chi Minh City, Vietnam

Author

Tra My, Phan Vu, Lam, Ha Minh, Thompson, Corinne N., Phuc, Hoang Le, Tuyet, Pham Thi Ngoc, Vinh, Ha, Hoang, Nguyen Van Minh, Minh, PhamVan, Vinh, Nguyen Thanh, Thuy, Cao Thu, Nga, Tran Thi Thu, Hau, Nguyen Thi Thu, Chinh, Nguyen Tran, Thuong, Tang Chi, Tuan, Ha Manh, Campbell, James I., Clements, Archie C.A., Farrar, Jeremy, Boni, Maciej F., and Baker, Stephen

Published
2013
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6. The validation and utility of a quantitative one-step multiplex RT real-time PCR targeting Rotavirus A and Norovirus

Author

Dung, Tran Thi Ngoc, Phat, Voong Vinh, Nga, Tran Vu Thieu, My, Phan Vu Tra, Duy, Pham Thanh, Campbell, James I., Thuy, Cao Thu, Hoang, Nguyen Van Minh, Van Minh, Pham, Le Phuc, Hoang, Tuyet, Pham Thi Ngoc, Vinh, Ha, Kien, Duong Thi Hue, Huy, Huynh Le Anh, Vinh, Nguyen Thanh, Nga, Tran Thi Thu, Hau, Nguyen Thi Thu, Chinh, Nguyen Tran, Thuong, Tang Chi, Tuan, Ha Manh, Simmons, Cameron, Farrar, Jeremy J., and Baker, Stephen

Published
2013
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7. Tracking the establishment of local endemic populations of an emergent enteric pathogen

Author

Holt, Kathryn E., Vu Thieu Nga, Tran, Thanh, Duy Pham, Vinh, Ha, Kim, Dong Wook, Vu Tra, My Phan, Campbell, James I., Van Minh Hoang, Nguyen, Vinh, Nguyen Thanh, Van Minh, Pham, Thuy, Cao Thu, Nga, Tran Thi Thu, Thompson, Corinne, Thi Ngoc Dung, Tran, Thi Khanh Nhu, Nguyen, Vinh, Phat Voong, Thi Ngoc Tuyet, Pham, Le Phuc, Hoang, Thi Nam Lien, Nguyen, Phu, Bui Duc, Thi Thuy Ai, Nguyen, Tien, Nguyen Manh, Dong, Nguyen, Parry, Christopher M., Hien, Tran Tinh, Farrar, Jeremy J., Parkhill, Julian, Dougan, Gordon, Thomson, Nicholas R., and Baker, Stephen

Published
2013

8. Kinetics of neutralising antibodies against Omicron variant in Vietnamese healthcare workers after primary immunisation with ChAdOx1-S and booster with BNT162b2

Author

Chau, Nguyen Van Vinh, primary, Nguyet, Lam Anh, additional, Dung, Nguyen Thanh, additional, Quang, Vo Minh, additional, Truong, Nguyen Thanh, additional, Toan, Le Mau, additional, Hung, Le Manh, additional, Man, Dinh Nguyen Huy, additional, Khoa, Dao Bach, additional, Phong, Nguyen Thanh, additional, Ngoc, Nghiem My, additional, Thao, Huynh Phuong, additional, Ty, Dinh Thi Bich, additional, Thanh, Pham Ba, additional, Ny, Nguyen Thi Han, additional, Thanh, Le Kim, additional, Thuy, Cao Thu, additional, Anh, Nguyen To, additional, Hong, Nguyen Thi Thu, additional, Nhu, Le Nguyen Truc, additional, Yen, Lam Minh, additional, Thwaites, Guy, additional, Thanh, Tran Tan, additional, and Tan, Le Van, additional

Published
2022
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9. Endemic norovirus infections in children, Ho Chi Minh City, Vietnam, 2009-2010

Author

My, Phan Vu Tra, Thompson, Corinne, Phuc, Hoang Le, Tuyet, Pham Thi Ngoc, Vinh, Ha, Hoang, Nguyen Van Minh, Van Minh, Pham, Vinh, Nguyen Thanh, Thuy, Cao Thu, Nga, Tran Thi Thu, Hau, Nguyen Thi Thu, Campbell, James, Chinh, Nguyen Tran, Thuong, Tang Chi, Tuan, Ha Manh, Farrar, Jeremy, and Baker, Stephen

Subjects
Research, Risk factors, Health aspects, Causes of, Norovirus -- Health aspects, Public health -- Research, Gastroenteritis -- Causes of -- Risk factors
Abstract

Norovirus (NoV) is a leading cause of acute gastroenteritis in children The Study This study was conducted in 3 hospitals (Children's Hospital 1, Children's Hospital 2, and the Hospital for [...]

Published
2013
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10. Emergence of carbapenem-resistant Acinetobacter baumannii as the major cause of ventilator-associated pneumonia in intensive care unit patients at an infectious disease hospital in southern Vietnam

Author

Nhu, Nguyen Thi Khanh, Lan, Nguyen Phu Huong, Campbell, James I., Parry, Christopher M., Thompson, Corinne, Tuyen, Ha Thanh, Hoang, Nguyen Van Minh, Tam, Pham Thi Thanh, Le, Vien Minh, Nga, Tran Vu Thieu, Nhu, Tran Do Hoang, Van Minh, Pham, Nga, Nguyen Thi Thu, Thuy, Cao Thu, Dung, Le Thi, Yen, Nguyen Thi Thu, Van Hao, Nguyen, Loan, Huynh Thi, Yen, Lam Minh, Nghia, Ho Dang Trung, Hien, Tran Tinh, Thwaites, Louise, Thwaites, Guy, Chau, Nguyen Van Vinh, and Baker, Stephen

Published
2014
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11. Colonization with Staphylococcus aureus and Klebsiella pneumoniae causes infections in a Vietnamese intensive care unit

Author

Thuy, Duong Bich, primary, Campbell, James, additional, Thuy, Cao Thu, additional, Hoang, Nguyen Van Minh, additional, Voong Vinh, Phat, additional, Nguyen, To Nguyen Thi, additional, Nguyen Ngoc Minh, Chau, additional, Pham, Duy Thanh, additional, Rabaa, Maia A., additional, Lan, Nguyen Phu Huong, additional, Hao, Nguyen Van, additional, Thwaites, Guy E., additional, Thwaites, C. Louise, additional, Baker, Stephen, additional, Chau, Nguyen Van Vinh, additional, and Chung The, Hao, additional

Published
2021
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12. Tetanus in Southern Vietnam: Current Situation

Author

Thuy, Duong Bich, primary, Campbell, James I., additional, Thanh, Tran Tan, additional, Thuy, Cao Thu, additional, Loan, Huynh Thi, additional, Hao, Nguyen Van, additional, Minh, Yen Lam, additional, Tan, Le Van, additional, Boni, Maciej F., additional, and Thwaites, C. Louise, additional

Published
2016
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13. A Prospective Multi-Center Observational Study of Children Hospitalized with Diarrhea in Ho Chi Minh City, Vietnam

Author

Thompson, Corinne N., primary, Minh, Pham Van, additional, Phuc, Hoang Le, additional, Thuong, Tang Chi, additional, Vinh, Ha, additional, Tu, Le Thi Phuong, additional, Thuy, Cao Thu, additional, Chau, Nguyen Van Vinh, additional, Tuyet, Pham Thi Ngoc, additional, Phan, My V. T., additional, Ngoc, Nguyen Minh, additional, Duy, Pham Thanh, additional, Nga, Tran Vu Thieu, additional, Duong, Vu Thuy, additional, Dung, Tran Thi Ngoc, additional, Chinh, Nguyen Tran, additional, Rabaa, Maia A., additional, Jenkins, Claire, additional, Hien, Tran Tinh, additional, Campbell, James I., additional, Vinh, Nguyen Thanh, additional, Phat, Voong Vinh, additional, Tuan, Ha Manh, additional, Baker, Stephen, additional, Tuyen, Ha Thanh, additional, Nga, Tran Thi Thu, additional, Yoshihara, Keisuke, additional, Thwaites, Guy, additional, and Hoang, Nguyen Van Minh, additional

Published
2015
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14. The dynamics of GII.4 Norovirus in Ho Chi Minh City, Vietnam

Author

My, Phan Vu Tra, Lam, Ha Minh, Thompson, Corinne, Phuc, Hoang Le, Tuyet, Pham Thi Ngoc, Vinh, Ha, Hoang, Nguyen Van Minh, Minh, PhamVan, Vinh, Nguyen Thanh, Thuy, Cao Thu, Clements, Archie, My, Phan Vu Tra, Lam, Ha Minh, Thompson, Corinne, Phuc, Hoang Le, Tuyet, Pham Thi Ngoc, Vinh, Ha, Hoang, Nguyen Van Minh, Minh, PhamVan, Vinh, Nguyen Thanh, Thuy, Cao Thu, and Clements, Archie

Abstract

Norovirus (NoV) is a major cause of epidemic gastroenteritis in industrialized countries, yet the epidemiological significance of NoV in industrializing countries remains poorly understood. The spatiotemporal distribution of NoV genotypes identified in 2054 enrolled children was investigated between May 2009 and December 2010, in Ho Chi Minh City (HCMC), Vietnam. A total of 315 NoV extracted from stool samples were genotyped and GPS mapped to their source. Genogroup II NoV, particularly GII.4, were predominant, and the GII.4 strains could be subgrouped into GII.4-2006b (Minerva) and GII.4-2010 (New Orleans) variants. There was no spatiotemporal structure among the endemic GII strains; yet a significant spatiotemporal signal corresponding with the novel introduction of GII.4-2010 variant was detected. These data show that NoV GII.4 variants are highly endemic in HCMC and describe a scenario of rapid NoV strain replacement occurring in HCMC in early 2010.

Published
2013

15. A Multi-Center Randomized Trial to Assess the Efficacy of Gatifloxacin versus Ciprofloxacin for the Treatment of Shigellosis in Vietnamese Children

Author

Vinh, Ha, primary, Anh, Vo Thi Cuc, additional, Anh, Nguyen Duc, additional, Campbell, James I., additional, Hoang, Nguyen Van Minh, additional, Nga, Tran Vu Thieu, additional, Nhu, Nguyen Thi Khanh, additional, Minh, Pham Van, additional, Thuy, Cao Thu, additional, Duy, Pham Thanh, additional, Phuong, Le Thi, additional, Loan, Ha Thi, additional, Chinh, Mai Thu, additional, Thao, Nguyen Thi Thu, additional, Tham, Nguyen Thi Hong, additional, Mong, Bui Li, additional, Bay, Phan Van Be, additional, Day, Jeremy N., additional, Dolecek, Christiane, additional, Lan, Nguyen Phu Huong, additional, Diep, To Song, additional, Farrar, Jeremy J., additional, Chau, Nguyen Van Vinh, additional, Wolbers, Marcel, additional, and Baker, Stephen, additional

Published
2011
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16. A Randomised Trial Evaluating the Safety and Immunogenicity of the Novel Single Oral Dose Typhoid Vaccine M01ZH09 in Healthy Vietnamese Children

Author

Hien, Tran Tinh, primary, Dung, Nguyen Thi, additional, Truong, Nguyen Thanh, additional, Van, Ninh Thi Thanh, additional, Bich Chau, Tran Nguyen, additional, Hoang, Nguyen Van Minh, additional, Nga, Tran Thi Thu, additional, Thuy, Cao Thu, additional, Minh, Pham Van, additional, Binh, Nguyen Thi Cam, additional, Ha, Tran Thi Diem, additional, Toi, Pham Van, additional, Song Diep, To, additional, Campbell, James I., additional, Stockwell, Elaine, additional, Schultsz, Constance, additional, Simmons, Cameron P., additional, Glover, Clare, additional, Lam, Winnie, additional, Marques, Filipe, additional, May, James P., additional, Upton, Anthony, additional, Budhram, Ronald, additional, Dougan, Gordon, additional, Farrar, Jeremy, additional, Vinh Chau, Nguyen Van, additional, and Dolecek, Christiane, additional

Published
2010
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17. The Sudden Dominance of blaCTX–M Harbouring Plasmids in Shigella spp. Circulating in Southern Vietnam

Author

Nhu, Nguyen Thi Khanh, primary, Vinh, Ha, additional, Nga, Tran Vu Thieu, additional, Stabler, Richard, additional, Duy, Pham Thanh, additional, Thi Minh Vien, Le, additional, van Doorn, H. Rogier, additional, Cerdeño-Tárraga, Ana, additional, Thomson, Nicholas, additional, Campbell, James, additional, Van Minh Hoang, Nguyen, additional, Thi Thu Nga, Tran, additional, Minh, Pham Van, additional, Thuy, Cao Thu, additional, Wren, Brendan, additional, Farrar, Jeremy, additional, and Baker, Stephen, additional

Published
2010
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18. A changing picture of shigellosis in southern Vietnam: shifting species dominance, antimicrobial susceptibility and clinical presentation

Author

Vinh, Ha, primary, Nhu, Nguyen Thi Khanh, additional, Nga, Tran Vu Thieu, additional, Duy, Pham Thanh, additional, Campbell, James I, additional, Hoang, Nguyen Van Minh, additional, Boni, Maciej F, additional, My, Phan Vu Tra, additional, Parry, Christopher, additional, Nga, Tran Thi Thu, additional, Van Minh, Pham, additional, Thuy, Cao Thu, additional, Diep, To Song, additional, Phuong, Le Thi, additional, Chinh, Mai Thu, additional, Loan, Ha Thi, additional, Tham, Nguyen Thi Hong, additional, Lanh, Mai Ngoc, additional, Mong, Bui Li, additional, Anh, Vo Thi Cuc, additional, Bay, Phan Van Be, additional, Chau, Nguyen Van Vinh, additional, Farrar, Jeremy, additional, and Baker, Stephen, additional

Published
2009
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19. The Sudden Dominance of blaCTX–M Harbouring Plasmids in Shigella spp. Circulating in Southern Vietnam.

Author

Nhu, Nguyen Thi Khanh, Vinh, Ha, Nga, Tran Vu Thieu, Stabler, Richard, Duy, Pham Thanh, Thi Minh Vien, Le, van Doorn, H. Rogier, Cerdeño-Tárraga, Ana, Thomson, Nicholas, Campbell, James, Van Minh Hoang, Nguyen, Thi Thu Nga, Tran, Minh, Pham Van, Thuy, Cao Thu, Wren, Brendan, Farrar, Jeremy, and Baker, Stephen

Subjects
NUCLEIC acid hybridization, SHIGELLOSIS, SHIGELLA, MICROBIAL sensitivity tests, PLASMIDS, KLEBSIELLA pneumoniae, ENTEROBACTER cloacae
Abstract

Background: Plasmid mediated antimicrobial resistance in the Enterobacteriaceae is a global problem. The rise of CTX-M class extended spectrum beta lactamases (ESBLs) has been well documented in industrialized countries. Vietnam is representative of a typical transitional middle income country where the spectrum of infectious diseases combined with the spread of drug resistance is shifting and bringing new healthcare challenges. Methodology: We collected hospital admission data from the pediatric population attending the hospital for tropical diseases in Ho Chi Minh City with Shigella infections. Organisms were cultured from all enrolled patients and subjected to antimicrobial susceptibility testing. Those that were ESBL positive were subjected to further investigation. These investigations included PCR amplification for common ESBL genes, plasmid investigation, conjugation, microarray hybridization and DNA sequencing of a blaCTX–M encoding plasmid. Principal Findings: We show that two different blaCTX-M genes are circulating in this bacterial population in this location. Sequence of one of the ESBL plasmids shows that rather than the gene being integrated into a preexisting MDR plasmid, the blaCTX-M gene is located on relatively simple conjugative plasmid. The sequenced plasmid (pEG356) carried the blaCTX-M-24 gene on an ISEcp1 element and demonstrated considerable sequence homology with other IncFI plasmids. Significance: The rapid dissemination, spread of antimicrobial resistance and changing population of Shigella spp. concurrent with economic growth are pertinent to many other countries undergoing similar development. Third generation cephalosporins are commonly used empiric antibiotics in Ho Chi Minh City. We recommend that these agents should not be considered for therapy of dysentery in this setting. Author Summary: Shigellosis is a disease caused by bacteria belonging to Shigella spp. and is a leading cause of bacterial gastrointestinal infections in infants in unindustrialized countries. The Shigellae are dynamic and capable of rapid change when placed under selective pressure in a human population. Extended spectrum beta lactamases (ESBLs) are enzymes capable of degrading cephalosporins (a group of antimicrobial agents) and the genes that encode them are common in pathogenic E. coli and other related organisms in industrialized countries. In southern Vietnam, we have isolated multiple cephalosporin-resistant Shigella that express ESBLs. Furthermore, over two years these strains have replaced strains isolated from patients with shigellosis that cannot express ESBLs. Our work describes the genes responsible for this characteristic and we investigate one of the elements carrying one of these genes. These finding have implications for treatment of shigellosis and support the growing necessity for vaccine development. Our findings also may be pertinent for other countries undergoing a similar economic transition to Vietnam's and the corresponding effect on bacterial populations. [ABSTRACT FROM AUTHOR]

Published
2010
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20. Emerging Enterovirus A71 Subgenogroup B5 Causing Severe Hand, Foot, and Mouth Disease, Vietnam, 2023.

Author

Chau NVV, Thuong TC, Hung NT, Hong NTT, Quy DT, Thien TB, Hiep CM, Minh NNQ, Khanh TH, Han DDK, Truc THC, Ny NTH, Thanh LK, Nguyet LA, Thuy CT, Nhu LNT, Van Quang P, Nguyen PNT, Qui PT, Rogier van Doorn H, Thwaites CL, Thanh TT, Dung NT, Thwaites G, Anh NT, Nhan LNT, and Van Tan L

Subjects
Child, Humans, Vietnam epidemiology, Lower Extremity, Antigens, Viral, Enterovirus genetics, Hand, Foot and Mouth Disease epidemiology, Enterovirus Infections epidemiology
Abstract

We report on a 2023 outbreak of severe hand, foot, and mouth disease in southern Vietnam caused by an emerging lineage of enterovirus A71 subgenogroup B5. Affected children were significantly older than those reported during previous outbreaks. The virus should be closely monitored to assess its potential for global dispersal.

Published
2024
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21. Spatiotemporal Evolution of SARS-CoV-2 Alpha and Delta Variants during Large Nationwide Outbreak of COVID-19, Vietnam, 2021.

Author

Tam NT, Anh NT, Tung TS, Thach PN, Dung NT, Trang VD, Hung LM, Dien TC, Ngoc NM, Van Duyet L, Cuong PM, Phuong HVM, Thai PQ, Tung NLN, Man DNH, Phong NT, Quang VM, Thoa PTN, Truong NT, Thao TNP, Linh DP, Tai NT, Bao HT, Vuong VT, Nhung HTK, Hong PND, Hanh LTP, Chung LT, Nhan NTT, Thanh TT, Hung DT, Mai HK, Long TH, Trang NT, Thuong NTH, Hong NTT, Nhu LNT, Ny NTH, Thuy CT, Thanh LK, Nguyet LA, Mai LTQ, Thuong TC, Nga LH, Thanh TT, Thwaites G, Rogier van Doorn H, Chau NVV, Kesteman T, and Van Tan L

Subjects
Humans, SARS-CoV-2 genetics, Vietnam epidemiology, Disease Outbreaks, COVID-19 epidemiology
Abstract

We analyzed 1,303 SARS-CoV-2 whole-genome sequences from Vietnam, and found the Alpha and Delta variants were responsible for a large nationwide outbreak of COVID-19 in 2021. The Delta variant was confined to the AY.57 lineage and caused >1.7 million infections and >32,000 deaths. Viral transmission was strongly affected by nonpharmaceutical interventions.

Published
2023
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22. Kinetics of Neutralizing Antibodies against Omicron Variant in Vietnamese Healthcare Workers after Primary Immunization with ChAdOx1-S and Booster Immunization with BNT162b2.

Author

Chau NVV, Nguyet LA, Dung NT, Quang VM, Truong NT, Toan LM, Hung LM, Man DNH, Khoa DB, Phong NT, Ngoc NM, Thao HP, Ty DTB, Thanh PB, Ny NTH, Thanh LK, Thuy CT, Anh NT, Hong NTT, Nhu LNT, Yen LM, Thwaites G, Thanh TT, and Tan LV

Subjects
Humans, Antibodies, Neutralizing, Kinetics, Immunization, Secondary, Southeast Asian People, SARS-CoV-2 genetics, Vaccination, ChAdOx1 nCoV-19, Breakthrough Infections, Health Personnel, Antibodies, Viral, BNT162 Vaccine, COVID-19 prevention & control
Abstract

We studied the development and persistence of neutralizing antibodies against SARS-CoV-2 ancestral strain, and Delta and Omicron (BA.1 and BA.2) variants in Vietnamese healthcare workers (HCWs) up to 15 weeks after booster vaccination. We included 47 HCWs, including group 1 (G1, N = 21) and group 2 (G2; N = 26) without and with breakthrough Delta variant infection before booster immunization, respectively). The study participants had completed primary immunization with ChAdOx1-S and booster vaccination with BNT162b2. Neutralizing antibodies were measured using a surrogate virus neutralization assay. Of the 21 study participants in G1, neutralizing antibodies against ancestral strain, Delta variant, BA.1, and BA.2 were (almost) abolished at month 8 after the second dose, but all had detectable neutralizing antibodies to the study viruses at week 2 post booster dose. Of the 26 study participants in G2, neutralizing antibody levels to BA.1 and BA.2 were significantly higher than those to the corresponding viruses measured at week 2 post breakthrough infection and before the booster dose. At week 15 post booster vaccination, neutralizing antibodies to BA.1 and BA.2 dropped significantly, with more profound changes observed in those without breakthrough Delta variant infection. Booster vaccination enhanced neutralizing activities against ancestral strain and Delta variant compared with those induced by primary vaccination. These responses were maintained at high levels for at least 15 weeks. Our findings emphasize the importance of the first booster dose in producing cross-neutralizing antibodies against Omicron variant. A second booster to maintain long-term vaccine effectiveness against the currently circulating variants merits further research.

Published
2022
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23. Tetanus in Southern Vietnam: Current Situation.

Author

Thuy DB, Campbell JI, Thanh TT, Thuy CT, Loan HT, Hao NV, Minh YL, Tan LV, Boni MF, and Thwaites CL

Subjects
Adult, Enzyme-Linked Immunosorbent Assay, Female, Humans, Male, Middle Aged, Public Health Administration, Tetanus Toxoid administration & dosage, Vaccination, Vietnam epidemiology, Young Adult, Tetanus epidemiology, Tetanus prevention & control, Tetanus Toxoid immunology
Abstract

In Vietnam, there are no accurate data on tetanus incidence to allow assessment of disease burden or vaccination program efficacy. We analyzed age structure of 786 tetanus cases admitted to a tertiary referral center in Vietnam for three separate years during an 18-year period to examine the impact of tetanus prevention programs, namely the Expanded Program on Immunization (EPI) and the Maternal and Neonatal Tetanus (MNT) initiative. Most cases were born before the initiation of EPI. Median age increased from 33 (interquartile range: 20-52) in 1994, to 46 (32-63) in 2012 (P < 0.001). Birth-year distribution was unchanged, indicating the same birth cohorts presented with tetanus in 1994, 2003, and 2012. Enzyme-linked immunosorbent assay measurements in 90 men and 90 women covered by MNT but not EPI showed 73.3% (95% confidence interval [CI]: 62.9-82.1%) of women had anti-tetanus antibody compared with 24.4% (95% CI: 15.9-34.7%) of men, indicating continued tetanus vulnerability in older men in Vietnam., (© The American Society of Tropical Medicine and Hygiene.)

Published
2017
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