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1. Author Correction: Common and rare variant associations with clonal haematopoiesis phenotypes

Author

Kessler, Michael D., Damask, Amy, O’Keeffe, Sean, Banerjee, Nilanjana, Li, Dadong, Watanabe, Kyoko, Marketta, Anthony, Van Meter, Michael, Semrau, Stefan, Horowitz, Julie, Tang, Jing, Kosmicki, Jack A., Rajagopal, Veera M., Zou, Yuxin, Houvras, Yariv, Ghosh, Arkopravo, Gillies, Christopher, Mbatchou, Joelle, White, Ryan R., Verweij, Niek, Bovijn, Jonas, Parikshak, Neelroop N., LeBlanc, Michelle G., Jones, Marcus, Glass, David J., Lotta, Luca A., Cantor, Michael N., Atwal, Gurinder S., Locke, Adam E., Ferreira, Manuel A. R., Deering, Raquel, Paulding, Charles, Shuldiner, Alan R., Thurston, Gavin, Ferrando, Adolfo A., Salerno, Will, Reid, Jeffrey G., Overton, John D., Marchini, Jonathan, Kang, Hyun M., Baras, Aris, Abecasis, Gonçalo R., and Jorgenson, Eric

Published
2025
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2. Intratumoral dendritic cell–CD4+ T helper cell niches enable CD8+ T cell differentiation following PD-1 blockade in hepatocellular carcinoma

Author

Magen, Assaf, Hamon, Pauline, Fiaschi, Nathalie, Soong, Brian Y., Park, Matthew D., Mattiuz, Raphaël, Humblin, Etienne, Troncoso, Leanna, D’souza, Darwin, Dawson, Travis, Kim, Joel, Hamel, Steven, Buckup, Mark, Chang, Christie, Tabachnikova, Alexandra, Schwartz, Hara, Malissen, Nausicaa, Lavin, Yonit, Soares-Schanoski, Alessandra, Giotti, Bruno, Hegde, Samarth, Ioannou, Giorgio, Gonzalez-Kozlova, Edgar, Hennequin, Clotilde, Le Berichel, Jessica, Zhao, Zhen, Ward, Stephen C., Fiel, Isabel, Kou, Baijun, Dobosz, Michael, Li, Lianjie, Adler, Christina, Ni, Min, Wei, Yi, Wang, Wei, Atwal, Gurinder S., Kundu, Kunal, Cygan, Kamil J., Tsankov, Alexander M., Rahman, Adeeb, Price, Colles, Fernandez, Nicolas, He, Jiang, Gupta, Namita T., Kim-Schulze, Seunghee, Gnjatic, Sacha, Kenigsberg, Ephraim, Deering, Raquel P., Schwartz, Myron, Marron, Thomas U., Thurston, Gavin, Kamphorst, Alice O., and Merad, Miriam

Published
2023
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6. Common and rare variant associations with clonal haematopoiesis phenotypes

Author

Kessler, Michael D., Damask, Amy, O’Keeffe, Sean, Banerjee, Nilanjana, Li, Dadong, Watanabe, Kyoko, Marketta, Anthony, Van Meter, Michael, Semrau, Stefan, Horowitz, Julie, Tang, Jing, Kosmicki, Jack A., Rajagopal, Veera M., Zou, Yuxin, Houvras, Yariv, Ghosh, Arkopravo, Gillies, Christopher, Mbatchou, Joelle, White, Ryan R., Verweij, Niek, Bovijn, Jonas, Parikshak, Neelroop N., LeBlanc, Michelle G., Jones, Marcus, Glass, David J., Lotta, Luca A., Cantor, Michael N., Atwal, Gurinder S., Locke, Adam E., Ferreira, Manuel A. R., Deering, Raquel, Paulding, Charles, Shuldiner, Alan R., Thurston, Gavin, Ferrando, Adolfo A., Salerno, Will, Reid, Jeffrey G., Overton, John D., Marchini, Jonathan, Kang, Hyun M., Baras, Aris, Abecasis, Gonçalo R., and Jorgenson, Eric

Published
2022
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7. A single-cell map of dynamic chromatin landscapes of immune cells in renal cell carcinoma

Author

Kourtis, Nikos, Wang, Qingqing, Wang, Bei, Oswald, Erin, Adler, Christina, Cherravuru, Samvitha, Malahias, Evangelia, Zhang, Lance, Golubov, Jacquelynn, Wei, Qiaozhi, Lemus, Samantha, Ni, Min, Ding, Yueming, Wei, Yi, Atwal, Gurinder S., Thurston, Gavin, Macdonald, Lynn E., Murphy, Andrew J., Dhanik, Ankur, Sleeman, Matthew A., Tykodi, Scott S., and Skokos, Dimitris

Published
2022
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8. Angiopoietin-2 blockade suppresses growth of liver metastases from pancreatic neuroendocrine tumors by promoting T cell recruitment

Author

Lee, Eunhyeong, O'Keefe, Sophie, Leong, Alessandra, Park, Ha-Ram, Varadarajan, Janani, Chowdhury, Subrata, Hiner, Shannon, Kim, Sungsoo, Shiva, Anahita, Friedman, Richard A., Remotti, Helen, Fojo, Tito, Yang, Hee Won, Thurston, Gavin, and Kim, Minah

Subjects
Regeneron Pharmaceuticals Inc. -- Growth, Immunohistochemistry -- Health aspects, T cells -- Growth, RNA sequencing -- Health aspects -- Growth, Metastasis -- Development and progression, Endothelium -- Growth, B cells -- Growth -- Health aspects, Genetic engineering -- Growth -- Health aspects, Pharmaceutical industry -- Growth -- Health aspects, Company growth, Health care industry
Abstract

Improving the management of metastasis in pancreatic neuroendocrine tumors (PanNETs) is critical, as nearly half of patients with PanNETs present with liver metastases, and this accounts for the majority of patient mortality. We identified angiopoietin-2 (ANGPT2) as one of the most upregulated angiogenic factors in RNA-Seq data from human PanNET liver metastases and found that higher ANGPT2 expression correlated with poor survival rates. Immunohistochemical staining revealed that ANGPT2 was localized to the endothelial cells of blood vessels in PanNET liver metastases. We observed an association between the upregulation of endothelial ANGPT2 and liver metastatic progression in both patients and transgenic mouse models of PanNETs. In human and mouse PanNET liver metastases, ANGPT2 upregulation coincided with poor T cell infiltration, indicative of an immunosuppressive tumor microenvironment. Notably, both pharmacologic inhibition and genetic deletion of ANGPT2 in PanNET mouse models slowed the growth of PanNET liver metastases. Furthermore, pharmacologic inhibition of ANGPT2 promoted T cell infiltration and activation in liver metastases, improving the survival of mice with metastatic PanNETs. These changes were accompanied by reduced plasma leakage and improved vascular integrity in metastases. Together, these findings suggest that ANGPT2 blockade may be an effective strategy for promoting T cell infiltration and immunostimulatory reprogramming to reduce the growth of liver metastases in PanNETs., Introduction Pancreatic neuroendocrine tumors (PanNETs) account for approximately 3%-5% of all pancreatic cancers. Their incidence has been steadily increasing over recent decades; however, they remain an understudied area of pancreatic [...]

Published
2023
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9. Neoadjuvant cemiplimab for resectable hepatocellular carcinoma: a single-arm, open-label, phase 2 trial

Author

Marron, Thomas U, Fiel, Maria Isabel, Hamon, Pauline, Fiaschi, Nathalie, Kim, Edward, Ward, Stephen C, Zhao, Zhen, Kim, Joel, Kennedy, Paul, Gunasekaran, Ganesh, Tabrizian, Parissa, Doroshow, Deborah, Legg, Meredith, Hammad, Ashley, Magen, Assaf, Kamphorst, Alice O, Shareef, Muhammed, Gupta, Namita T, Deering, Raquel, Wang, Wei, Wang, Fang, Thanigaimani, Pradeep, Mani, Jayakumar, Troncoso, Leanna, Tabachnikova, Alexandra, Chang, Christie, Akturk, Guray, Buckup, Mark, Hamel, Steven, Ioannou, Giorgio, Hennequin, Clotilde, Jamal, Hajra, Brown, Haley, Bonaccorso, Antoinette, Labow, Daniel, Sarpel, Umut, Rosenbloom, Talia, Sung, Max W, Kou, Baijun, Li, Siyu, Jankovic, Vladimir, James, Nicola, Hamon, Sara C, Cheung, Hung Kam, Sims, Jennifer S, Miller, Elizabeth, Bhardwaj, Nina, Thurston, Gavin, Lowy, Israel, Gnjatic, Sacha, Taouli, Bachir, Schwartz, Myron E, and Merad, Miriam

Published
2022
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11. Single-cell analysis of human non-small cell lung cancer lesions refines tumor classification and patient stratification

Author

Leader, Andrew M., Grout, John A., Maier, Barbara B., Nabet, Barzin Y., Park, Matthew D., Tabachnikova, Alexandra, Chang, Christie, Walker, Laura, Lansky, Alona, Le Berichel, Jessica, Troncoso, Leanna, Malissen, Nausicaa, Davila, Melanie, Martin, Jerome C., Magri, Giuliana, Tuballes, Kevin, Zhao, Zhen, Petralia, Francesca, Samstein, Robert, D’Amore, Natalie Roy, Thurston, Gavin, Kamphorst, Alice O., Wolf, Andrea, Flores, Raja, Wang, Pei, Müller, Sören, Mellman, Ira, Beasley, Mary Beth, Salmon, Hélène, Rahman, Adeeb H., Marron, Thomas U., Kenigsberg, Ephraim, and Merad, Miriam

Published
2021
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12. Cemiplimab in locally advanced basal cell carcinoma after hedgehog inhibitor therapy: an open-label, multi-centre, single-arm, phase 2 trial

Author

Stratigos, Alexander J, Sekulic, Aleksandar, Peris, Ketty, Bechter, Oliver, Prey, Sorilla, Kaatz, Martin, Lewis, Karl D, Basset-Seguin, Nicole, Chang, Anne Lynn S, Dalle, Stèphane, Orland, Almudena Fernandez, Licitra, Lisa, Robert, Caroline, Ulrich, Claas, Hauschild, Axel, Migden, Michael R, Dummer, Reinhard, Li, Siyu, Yoo, Suk-Young, Mohan, Kosalai, Coates, Ebony, Jankovic, Vladimir, Fiaschi, Nathalie, Okoye, Emmanuel, Bassukas, Ioannis D, Loquai, Carmen, De Giorgi, Vincenzo, Eroglu, Zeynep, Gutzmer, Ralf, Ulrich, Jens, Puig, Susana, Seebach, Frank, Thurston, Gavin, Weinreich, David M, Yancopoulos, George D, Lowy, Israel, Bowler, Timothy, and Fury, Matthew G

Published
2021
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14. Author Correction: Common and rare variant associations with clonal haematopoiesis phenotypes

Author

Kessler, Michael D., Damask, Amy, O’Keeffe, Sean, Banerjee, Nilanjana, Li, Dadong, Watanabe, Kyoko, Marketta, Anthony, Van Meter, Michael, Semrau, Stefan, Horowitz, Julie, Tang, Jing, Kosmicki, Jack A., Rajagopal, Veera M., Zou, Yuxin, Houvras, Yariv, Ghosh, Arkopravo, Gillies, Christopher, Mbatchou, Joelle, White, Ryan R., Verweij, Niek, Bovijn, Jonas, Parikshak, Neelroop N., LeBlanc, Michelle G., Jones, Marcus, Glass, David J., Lotta, Luca A., Cantor, Michael N., Atwal, Gurinder S., Locke, Adam E., Ferreira, Manuel A. R., Deering, Raquel, Paulding, Charles, Shuldiner, Alan R., Thurston, Gavin, Ferrando, Adolfo A., Salerno, Will, Reid, Jeffrey G., Overton, John D., Marchini, Jonathan, Kang, Hyun M., Baras, Aris, Abecasis, Gonçalo R., and Jorgenson, Eric

Published
2023
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15. Antibody drug conjugates of cleavable amino-benzoyl-maytansinoids

Author

Nittoli, Thomas, Delfino, Frank, Kelly, Marcus, Carosso, Serena, Markotan, Thomas, Kunz, Arthur, Chen, Zhaoyuan, Mao, Shu, Shan, Jing, Navarro, Elizabeth, Zhao, Feng, Makonnen, Sosina, Hickey, Carlos, Spink, Jan, Olson, William, Kirshner, Jessica R., Thurston, Gavin, and Papadopoulos, Nicholas

Published
2020
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16. Opposing actions of angiopoietin-2 on Tie2 signaling and FOXO1 activation

Author

Kim, Minah, Allen, Breanna, Korhonen, Emilia A, Nitschké, Maximilian, Yang, Hee Won, Baluk, Peter, Saharinen, Pipsa, Alitalo, Kari, Daly, Christopher, Thurston, Gavin, and McDonald, Donald M

Subjects
Medical Physiology, Biomedical and Clinical Sciences, Cardiovascular, Angiopoietin-2, Animals, Antibodies, Monoclonal, Endothelial Cells, Endothelium, Vascular, Female, Forkhead Box Protein O1, Humans, Inflammation, Male, Mice, Mice, Inbred C3H, Mice, Inbred C57BL, Mice, Transgenic, Mycoplasma pulmonis, Phosphatidylinositol 3-Kinases, Protein Domains, Receptor, TIE-2, Vascular Endothelial Growth Factor A, Vascular Remodeling, Medical and Health Sciences, Immunology, Biological sciences, Biomedical and clinical sciences, Health sciences
Abstract

Angiopoietin-2 (ANG2) regulates blood vessel remodeling in many pathological conditions through differential effects on Tie2 signaling. While ANG2 competes with ANG1 to inhibit Tie2, it can paradoxically also promote Tie2 phosphorylation (p-Tie2). A related paradox is that both inactivation and overactivation of Tie2 can result in vascular remodeling. Here, we reconciled these opposing actions of ANG2 by manipulating conditions that govern its actions in the vasculature. ANG2 drove vascular remodeling during Mycoplasma pulmonis infection by acting as a Tie2 antagonist, which led to p-Tie2 suppression, forkhead box O1 (FOXO1) activation, increased ANG2 expression, and vessel leakiness. These changes were exaggerated by anti-Tie2 antibody, inhibition of PI3K signaling, or ANG2 overexpression and were reduced by anti-ANG2 antibody or exogenous ANG1. In contrast, under pathogen-free conditions, ANG2 drove vascular remodeling by acting as an agonist, promoting high p-Tie2, low FOXO1 activation, and no leakage. Tie1 activation was strong under pathogen-free conditions, but infection or TNF-α led to Tie1 inactivation by ectodomain cleavage and promoted the Tie2 antagonist action of ANG2. Together, these data indicate that ANG2 activation of Tie2 supports stable enlargement of normal nonleaky vessels, but reduction of Tie1 in inflammation leads to ANG2 antagonism of Tie2 and initiates a positive feedback loop wherein FOXO1-driven ANG2 expression promotes vascular remodeling and leakage.

Published
2016

36. Generation of T-cell-redirecting bispecific antibodies with differentiated profiles of cytokine release and biodistribution by CD3 affinity tuning

Author

Haber, Lauric, Olson, Kara, Kelly, Marcus P., Crawford, Alison, DiLillo, David J., Tavaré, Richard, Ullman, Erica, Mao, Shu, Canova, Lauren, Sineshchekova, Olga, Finney, Jennifer, Pawashe, Arpita, Patel, Supriya, McKay, Ryan, Rizvi, Sahar, Damko, Ermelinda, Chiu, Danica, Vazzana, Kristin, Ram, Priyanka, Mohrs, Katja, D’Orvilliers, Amanda, Xiao, Jenny, Makonnen, Sosina, Hickey, Carlos, Arnold, Cody, Giurleo, Jason, Chen, Ya Ping, Thwaites, Courtney, Dudgeon, Drew, Bray, Kevin, Rafique, Ashique, Huang, Tammy, Delfino, Frank, Hermann, Aynur, Kirshner, Jessica R., Retter, Marc W., Babb, Robert, MacDonald, Douglas, Chen, Gang, Olson, William C., Thurston, Gavin, Davis, Samuel, Lin, John C., and Smith, Eric

Published
2021
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37. Antibody drug conjugates of cleavable amino-alkyl and aryl maytansinoids

Author

Nittoli, Thomas, Kelly, Marcus P., Delfino, Frank, Rudge, John, Kunz, Arthur, Markotan, Thomas, Spink, Jan, Chen, Zhaoyuan, Shan, Jing, Navarro, Elizabeth, Tait, Michele, Provoncha, Kathleen, Giurleo, Jason, Zhao, Feng, Jiang, Xiaobo, Hylton, Donna, Makonnen, Sosina, Hickey, Carlos, Kirshner, Jessica R., Thurston, Gavin, and Papadopoulos, Nicholas

Published
2018
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41. IL-6–GP130 signaling protects human hepatocytes against lipid droplet accumulation in humanized liver models

Author

Carbonaro, Marisa, primary, Wang, Kehui, additional, Huang, Hui, additional, Frleta, Davor, additional, Patel, Aditi, additional, Pennington, Alexander, additional, Desclaux, Mathieu, additional, Moller-Tank, Sven, additional, Grindley, Justin, additional, Altarejos, Judith, additional, Zhong, Jun, additional, Polites, Greg, additional, Poueymirou, William, additional, Jaspers, Stephen, additional, Kyratsous, Christos, additional, Zambrowicz, Brian, additional, Murphy, Andrew, additional, Lin, John C., additional, Macdonald, Lynn E., additional, Daly, Christopher, additional, Sleeman, Mark, additional, Thurston, Gavin, additional, and Li, Zhe, additional

Published
2023
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42. Abstract 1780: TCR-T and CAR-T cells targeting HLA-A2/MAGEA4 demonstrate differential tumor control, reflecting co-stimulatory signaling requirements

Author

Decker, Corinne E., primary, Idun, Jacqueline, additional, Mohrs, Katja, additional, Meagher, Thomas, additional, Bray, Kevin, additional, Petriv, Iryna, additional, Golas, Jonathon, additional, Helms, Timothy, additional, Ajithdoss, Dharani, additional, Thurston, Gavin, additional, Lin, John, additional, Kirshner, Jessica R., additional, and DiLillo, David J., additional

Published
2023
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43. Abstract 4134: Boosting anti-tumor immunity by promoting high endothelial venule and tertiary lymphoid structure formation in solid tumors via LTBR agonism

Author

An, Disi, primary, Chen, Guoying, additional, Wang, Wei, additional, Mohrs, Katja, additional, DiLillo, David, additional, Daly, Christopher, additional, Thurston, Gavin, additional, Lin, John, additional, Gupta, Namita, additional, Atwal, Mickey, additional, and Kuhnert, Frank, additional

Published
2023
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44. Supplementary Data from Immuno-PET Monitoring of Lymphocytes Using the CD8-Specific Antibody REGN5054

Author

Tavaré, Richard, primary, Danton, Makenzie, primary, Giurleo, Jason T., primary, Makonnen, Sosina, primary, Hickey, Carlos, primary, Arnold, Tomas C., primary, Kelly, Marcus P., primary, Fredriksson, Fanny, primary, Bruestle, Karina, primary, Hermann, Aynur, primary, Ullman, Erica, primary, Edelmann, Kurt H., primary, Potocky, Terra, primary, Dudgeon, Drew, primary, Bhatt, Nikunj B., primary, Doubrovin, Mikhail, primary, Barry, Thomas, primary, Kyratsous, Christos A., primary, Gurer, Cagan, primary, Tu, Naxin, primary, Gartner, Hans, primary, Murphy, Andrew, primary, Macdonald, Lynn E., primary, Popke, Jon, primary, Mintz, Akiva, primary, Griesemer, Adam, primary, Olson, William C., primary, Thurston, Gavin, primary, Ma, Dangshe, primary, and Kirshner, Jessica R., primary

Published
2023
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45. Data from A PSMA-Targeting CD3 Bispecific Antibody Induces Antitumor Responses that Are Enhanced by 4-1BB Costimulation

Author

Chiu, Danica, primary, Tavaré, Richard, primary, Haber, Lauric, primary, Aina, Olulanu H., primary, Vazzana, Kristin, primary, Ram, Priyanka, primary, Danton, Makenzie, primary, Finney, Jennifer, primary, Jalal, Sumreen, primary, Krueger, Pamela, primary, Giurleo, Jason T., primary, Ma, Dangshe, primary, Smith, Eric, primary, Thurston, Gavin, primary, Kirshner, Jessica R., primary, and Crawford, Alison, primary

Published
2023
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47. Data from Immuno-PET Monitoring of Lymphocytes Using the CD8-Specific Antibody REGN5054

Author

Tavaré, Richard, primary, Danton, Makenzie, primary, Giurleo, Jason T., primary, Makonnen, Sosina, primary, Hickey, Carlos, primary, Arnold, Tomas C., primary, Kelly, Marcus P., primary, Fredriksson, Fanny, primary, Bruestle, Karina, primary, Hermann, Aynur, primary, Ullman, Erica, primary, Edelmann, Kurt H., primary, Potocky, Terra, primary, Dudgeon, Drew, primary, Bhatt, Nikunj B., primary, Doubrovin, Mikhail, primary, Barry, Thomas, primary, Kyratsous, Christos A., primary, Gurer, Cagan, primary, Tu, Naxin, primary, Gartner, Hans, primary, Murphy, Andrew, primary, Macdonald, Lynn E., primary, Popke, Jon, primary, Mintz, Akiva, primary, Griesemer, Adam, primary, Olson, William C., primary, Thurston, Gavin, primary, Ma, Dangshe, primary, and Kirshner, Jessica R., primary

Published
2023
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48. Abstract 2178: Circulating tumor DNA (ctDNA) correlates closely with tumor necrosis and relapse-free survival (RFS) in hepatocellular carcinoma (HCC) patients treated with perioperative cemiplimab

Author

Marron, Thomas U., primary, Brennan, Laura, additional, Hamon, Pauline, additional, Fiel, Maria Isabel, additional, Ward, Stephen C., additional, Zhu, Yuan O., additional, Kim, Edward, additional, Kamphorst, Alice O., additional, Thanigaimani, Pradeep, additional, Uldrick, Thomas S., additional, Lucas, Natalie, additional, Wu, Kathy, additional, Hapanowicz, Olivia, additional, King, Paula, additional, Li, Siyu, additional, Miller, Elizabeth, additional, Bhardwaj, Nina, additional, Thurston, Gavin, additional, Lowy, Israel, additional, Gnjatic, Sacha, additional, Schwartz, Myron E., additional, Jankovic, Vladimir, additional, and Merad, Miriam, additional

Published
2023
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49. Supplementary Figures 1-7 from A PSMA-Targeting CD3 Bispecific Antibody Induces Antitumor Responses that Are Enhanced by 4-1BB Costimulation

Author

Chiu, Danica, primary, Tavaré, Richard, primary, Haber, Lauric, primary, Aina, Olulanu H., primary, Vazzana, Kristin, primary, Ram, Priyanka, primary, Danton, Makenzie, primary, Finney, Jennifer, primary, Jalal, Sumreen, primary, Krueger, Pamela, primary, Giurleo, Jason T., primary, Ma, Dangshe, primary, Smith, Eric, primary, Thurston, Gavin, primary, Kirshner, Jessica R., primary, and Crawford, Alison, primary

Published
2023
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