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8. Betibeglogene autotemcel gene therapy in patients with transfusion-dependent, severe genotype β-thalassaemia (HGB-212): a non-randomised, multicentre, single-arm, open-label, single-dose, phase 3 trial

Author

Kwiatkowski, Janet L, Walters, Mark C, Hongeng, Suradej, Yannaki, Evangelia, Kulozik, Andreas E, Kunz, Joachim B, Sauer, Martin G, Thrasher, Adrian J, Thuret, Isabelle, Lal, Ashutosh, Tao, Ge, Ali, Shamshad, Thakar, Himal L, Elliot, Heidi, Lodaya, Ankit, Lee, Ji, Colvin, Richard A, Locatelli, Franco, and Thompson, Alexis A

Published
2024
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9. Islet-after-kidney transplantation versus kidney alone in kidney transplant recipients with type 1 diabetes (KAIAK): a population-based target trial emulation in France

Author

Armanet, Mathieu, Auxenfans, Céline, Averland, Benoit, Benhamou, Pierre-Yves, Benotmane, Ilies, Berishvili, Ekaterine, Bertrand, Dominique, Blanot, Stéphane, Borot, Sophie, Branchereau, Julien, Broca, Christophe, Brunet, Valérie, Cattan, Pierre, Chaillous, Lucy, Chatauret, Nicolas, Cheisson, Gaelle, Ciacio, Oriana, Colosio, Charlotte, Cornuault, Mathieu, Cuellar, Emmanuel, Defortescu, Guillaume, Defrance, Frédérique, Deshayes, Aurélie, Divard, Gillian, Domet, Thomas, Duffas, Jean-Pierre, Elias, Michelle, Faivre, Lionel, Gaudez, François, Giral, Magali, Girerd, Sophie, Gmyr, Valery, Gouin, Philippe, Gregoire, Hélène, Gueguen, Juliette, Haidar, Fadi, Hubert, Thomas, Janbon, Bénédicte, Jeantet, Marine, Karam, Georges, Kerbaul, François, Kerleau, Clarisse, Kounis, Ilias, Laporte, Caroline, Laurent, Charlotte, Lejay, Anne, Masset, Christophe, Mazeaud, Charles, Mokri, Laëtitia, Moreau, Karine, Morellon, Emmanuel, Muscari, Fabrice, Nasone, Justine, Padilla, Marc, Parier, Bastien, Pastural, Myriam, Perrier, Quentin, Pittau, Gabriella, Prudhomme, Thomas, Renard, Eric, Raverdy, Violeta, Sá Cunha, António, Salloum, Chady, Seizilles De Mazancourt, Emilien, Snanoudj, Renaud, Thaunat, Oliver, Thuret, Rodolphe, Timsit, Marc-Oliver, Vachiery-Lahaye, Florence, Maanaoui, Mehdi, Lenain, Rémi, Foucher, Yohann, Buron, Fanny, Blancho, Gilles, Antoine, Corinne, Caillard, Sophie, Kessler, Laurence, Le Quintrec, Moglie, Villard, Orianne, Anglicheau, Dany, Büchler, Matthias, Brodin-Sartorius, Albane, Frimat, Luc, Malvezzi, Paolo, Lablanche, Sandrine, Badet, Lionel, Esposito, Laure, Chetboun, Mikael, Hamroun, Aghiles, Kerr-Conte, Julie, Berney, Thierry, Vantyghem, Marie-Christine, Hazzan, Marc, and Pattou, François

Published
2024
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15. Diet and depression: future needs to unlock the potential

Author

Marx, Wolfgang, Lane, Melissa M, Hockey, Meghan, Aslam, Hajara, Walder, Ken, Borsini, Alessandra, Firth, Joseph, Pariante, Carmine M, Berding, Kirsten, Cryan, John F, Clarke, Gerard, Craig, Jeffrey M, Su, Kuan-Pin, Mischoulon, David, Gomez-Pinilla, Fernando, Foster, Jane A, Cani, Patrice D, Thuret, Sandrine, Staudacher, Heidi M, Sánchez-Villegas, Almudena, Arshad, Husnain, Akbaraly, Tasnime, O’Neil, Adrienne, and Jacka, Felice N

Subjects
Biomedical and Clinical Sciences, Biological Psychology, Clinical and Health Psychology, Clinical Sciences, Psychology, Depression, Diet, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry, Clinical sciences, Biological psychology, Clinical and health psychology
Published
2022

20. Keratoconus and the Impact of Treatment on Patients’ Quality of Life: A Qualitative Study

Author

Fournié, Pierre, Acquadro, Michaël, Touboul, David, Cochener, Béatrice, Chiambaretta, Frédéric, Muraine, Marc, Borderie, Vincent, Bourges, Jean-Louis, Benmedjahed, Khadra, Tugaut, Béatrice, Bernheim, Diane, Bourcier, Tristan, Burillon, Carole, David, Thierry, Delbosc, Bernard, Gain, Philippe, Hoffart, Louis, Labetoulle, Marc, Laroche, Laurent, Malet, Florence, Orignac, Isabelle, Robert, Pierre-Yves, Thuret, Gilles, Vabres, Bertrand, Malecaze, François, and Arnould, Benoit

Published
2023
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23. Recent results of hematopoietic stem cell transplantation for thalassemia with busulfan-based conditioning regimen in France: improved thalassemia free survival despite frequent mixed chimerism. A retrospective study from the Francophone Society of Stem Cell Transplantation and Cellular Therapy (SFGM-TC)

Author

Rossi, Marica, Szepetowski, Sarah, Yakouben, Karima, Paillard, Catherine, Sirvent, Anne, Castelle, Martin, Pegon, Charline, Piguet, Christophe, Grain, Audrey, Angoso, Marie, Robin, Marie, Dhedin, Nathalie, Pondarré, Corinne, Dumesnil de Maricourt, Cécile, Berceanu, Ana, Simon, Pauline, Marcais, Ambroise, Poirée, Maryline, Gandemer, Virginie, Plantaz, Dominique, Nguyen, Stéphanie, Michel, Gérard, Loundou, Anderson, Dalle, Jean-Hugues, and Thuret, Isabelle

Published
2023
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25. Deacetylation of H4-K16Ac and heterochromatin assembly in senescence

Author

Contrepois Kévin, Thuret Jean-Yves, Courbeyrette Régis, Fenaille François, and Mann Carl

Subjects
Genetics, QH426-470
Abstract

Abstract Background Cellular senescence is a stress response of mammalian cells leading to a durable arrest of cell proliferation that has been implicated in tumor suppression, wound healing, and aging. The proliferative arrest is mediated by transcriptional repression of genes essential for cell division by the retinoblastoma protein family. This repression is accompanied by varying degrees of heterochromatin assembly, but little is known regarding the molecular mechanisms involved. Results We found that both deacetylation of H4-K16Ac and expression of HMGA1/2 can contribute to DNA compaction during senescence. SIRT2, an NAD-dependent class III histone deacetylase, contributes to H4-K16Ac deacetylation and DNA compaction in human fibroblast cell lines that assemble striking senescence-associated heterochromatin foci (SAHFs). Decreased H4-K16Ac was observed in both replicative and oncogene-induced senescence of these cells. In contrast, this mechanism was inoperative in a fibroblast cell line that did not assemble extensive heterochromatin during senescence. Treatment of senescent cells with trichostatin A, a class I/II histone deacetylase inhibitor, also induced rapid and reversible decondensation of SAHFs. Inhibition of DNA compaction did not significantly affect the stability of the senescent state. Conclusions Variable DNA compaction observed during senescence is explained in part by cell-type specific regulation of H4 deacetylation and HMGA1/2 expression. Deacetylation of H4-K16Ac during senescence may explain reported decreases in this mark during mammalian aging and in cancer cells.

Published
2012
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26. Evaluation of time profile reconstruction from complex two-color microarray designs

Author

Engelen Kristof, Thuret Raphael, Fierro Ana C, Bernot Gilles, Marchal Kathleen, and Pollet Nicolas

Subjects
Computer applications to medicine. Medical informatics, R858-859.7, Biology (General), QH301-705.5
Abstract

Abstract Background As an alternative to the frequently used "reference design" for two-channel microarrays, other designs have been proposed. These designs have been shown to be more profitable from a theoretical point of view (more replicates of the conditions of interest for the same number of arrays). However, the interpretation of the measurements is less straightforward and a reconstruction method is needed to convert the observed ratios into the genuine profile of interest (e.g. a time profile). The potential advantages of using these alternative designs thus largely depend on the success of the profile reconstruction. Therefore, we compared to what extent different linear models agree with each other in reconstructing expression ratios and corresponding time profiles from a complex design. Results On average the correlation between the estimated ratios was high, and all methods agreed with each other in predicting the same profile, especially for genes of which the expression profile showed a large variance across the different time points. Assessing the similarity in profile shape, it appears that, the more similar the underlying principles of the methods (model and input data), the more similar their results. Methods with a dye effect seemed more robust against array failure. The influence of a different normalization was not drastic and independent of the method used. Conclusion Including a dye effect such as in the methods lmbr_dye, anovaFix and anovaMix compensates for residual dye related inconsistencies in the data and renders the results more robust against array failure. Including random effects requires more parameters to be estimated and is only advised when a design is used with a sufficient number of replicates. Because of this, we believe lmbr_dye, anovaFix and anovaMix are most appropriate for practical use.

Published
2008
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28. Exploring nervous system transcriptomes during embryogenesis and metamorphosis in Xenopus tropicalis using EST analysis

Author

Wegnez Maurice, Perron Muriel, Demeneix Barbara A, Coen Laurent, Thuret Raphaël, Fierro Ana C, Gyapay Gabor, Weissenbach Jean, Wincker Patrick, Mazabraud André, and Pollet Nicolas

Subjects
Biotechnology, TP248.13-248.65, Genetics, QH426-470
Abstract

Abstract Background The western African clawed frog Xenopus tropicalis is an anuran amphibian species now used as model in vertebrate comparative genomics. It provides the same advantages as Xenopus laevis but is diploid and has a smaller genome of 1.7 Gbp. Therefore X. tropicalis is more amenable to systematic transcriptome surveys. We initiated a large-scale partial cDNA sequencing project to provide a functional genomics resource on genes expressed in the nervous system during early embryogenesis and metamorphosis in X. tropicalis. Results A gene index was defined and analysed after the collection of over 48,785 high quality sequences. These partial cDNA sequences were obtained from an embryonic head and retina library (30,272 sequences) and from a metamorphic brain and spinal cord library (27,602 sequences). These ESTs are estimated to represent 9,693 transcripts derived from an estimated 6,000 genes. Comparison of these cDNA sequences with protein databases indicates that 46% contain their start codon. Further annotation included Gene Ontology functional classification, InterPro domain analysis, alternative splicing and non-coding RNA identification. Gene expression profiles were derived from EST counts and used to define transcripts specific to metamorphic stages of development. Moreover, these ESTs allowed identification of a set of 225 polymorphic microsatellites that can be used as genetic markers. Conclusion These cDNA sequences permit in silico cloning of numerous genes and will facilitate studies aimed at deciphering the roles of cognate genes expressed in the nervous system during neural development and metamorphosis. The genomic resources developed to study X. tropicalis biology will accelerate exploration of amphibian physiology and genetics. In particular, the model will facilitate analysis of key questions related to anuran embryogenesis and metamorphosis and its associated regulatory processes.

Published
2007
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29. Diet and depression: exploring the biological mechanisms of action

Author

Marx, Wolfgang, Lane, Melissa, Hockey, Meghan, Aslam, Hajara, Berk, Michael, Walder, Ken, Borsini, Alessandra, Firth, Joseph, Pariante, Carmine M, Berding, Kirsten, Cryan, John F, Clarke, Gerard, Craig, Jeffrey M, Su, Kuan-Pin, Mischoulon, David, Gomez-Pinilla, Fernando, Foster, Jane A, Cani, Patrice D, Thuret, Sandrine, Staudacher, Heidi M, Sánchez-Villegas, Almudena, Arshad, Husnain, Akbaraly, Tasnime, O’Neil, Adrienne, Segasby, Toby, and Jacka, Felice N

Subjects
Medical Biochemistry and Metabolomics, Biomedical and Clinical Sciences, Neurosciences, Obesity, Complementary and Integrative Health, Depression, Brain Disorders, Nutrition, Behavioral and Social Science, Mental Health, Oral and gastrointestinal, Mental health, Good Health and Well Being, Animals, Diet, Epigenesis, Genetic, Gastrointestinal Microbiome, Humans, Inflammation, Oxidative Stress, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry, Clinical sciences, Biological psychology, Clinical and health psychology
Abstract

The field of nutritional psychiatry has generated observational and efficacy data supporting a role for healthy dietary patterns in depression onset and symptom management. To guide future clinical trials and targeted dietary therapies, this review provides an overview of what is currently known regarding underlying mechanisms of action by which diet may influence mental and brain health. The mechanisms of action associating diet with health outcomes are complex, multifaceted, interacting, and not restricted to any one biological pathway. Numerous pathways were identified through which diet could plausibly affect mental health. These include modulation of pathways involved in inflammation, oxidative stress, epigenetics, mitochondrial dysfunction, the gut microbiota, tryptophan-kynurenine metabolism, the HPA axis, neurogenesis and BDNF, epigenetics, and obesity. However, the nascent nature of the nutritional psychiatry field to date means that the existing literature identified in this review is largely comprised of preclinical animal studies. To fully identify and elucidate complex mechanisms of action, intervention studies that assess markers related to these pathways within clinically diagnosed human populations are needed.

Published
2021

31. Effect of Cardiac Arrest in Brain-dead Donors on Kidney Graft Function

Author

Dubourg, Quentin, Savoye, Emilie, Drouin, Sarah, Legeai, Camille, Barrou, Benoit, Rondeau, Eric, Buob, David, Kerbaul, Francois, Bronchard, Régis, Galichon, Pierre, OUENDO, Martial, AARNINCK, Alice, ARMAND, Aurore, BADET, Lionel, BERTRAND, Dominique, BESSEDE, Thomas, BOISSER, Romain, BOUVIER, Nicolas, BRUYERE, Franck, BUCHLER, Mathias, BURON, Fanny, CERUTI, Florian, CHAKFE, Nabil, CHAUVEAU, Bertrand, CHAUVET, Romain, CHEISSON, Gaëlle, CHOUKROUN, Gabriel, CORNUAULT, Mathieu, DEL BELLO, Arnaud, DUCLOUX, Didier, EPINAT, Magali, ESCHWEGE, Pascal, FEDOU, Anne-Laure, GAUDEZ, François, GIRERD, Sophie, GOLBIN, Léonard, GRALL-JEZEQUEL, GREGOIRE, Arnaud, GREGOIRE, Hélène, GRIMBERT, Philippe, DUCOS, Guillaume, GUILLOU, Yves-Marie, HAZZAN, Marc, JALAL-EDDINE, Arwa, JAMBON, Frédéric, JANBON, Bénédicte, KAMAR, Nassim, KAMINSKI, Hannah, KERFORNE, Thomas, LANFRANCO, Luca, LE MEUR, Yannick, LECHEVALLIER, Eric, LEFAUCHEUR, Carmen, LEGRIS, Tristan, LEJAY, Anne, LENAIN, Rémi, LEONE, Marc, MAILLARD, Nicolas, MANAOUI, Medhi, MATILLON, Xavier, MEBAAZA, Alexandre, MILLET, Clémentine, MOAL, Valérie, MONTINI, Florent, MORELON, Emmanuel, NOBLE, Johan, ORIEUX, Arthur, PADILLA, Marc, PARIER, Bastien, PICQUET, Jean, PLAUD, Benoit, PRIN, Sébastien, PRUDHOMME, Thomas, REBILLARD, Rose-Marie, ROGIER, Julien, SALLUSTO, Federico, SALMON-GANDONNIERE, Charlotte, SI LARBI, Anne Gaelle, SNANOUDJ, Renaud, SOOROJEBALLY, Yanish, TERRIER, Nicolas, THIERRY, Antoine, THURET, Rodolphe, VALLEE, Maxime, VEDRINE, Nicolas, VENHARD, Jean Christophe, and WOLF, Philippe Coordination

Published
2023
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34. Updated National Study of Functional Graft Renal Cell Carcinomas: Are They a Different Entity?

Author

Szabla, Nicolas, Matillon, Xavier, Calves, Jehanne, Branchereau, Julien, Champy, Cécile, Neuzillet, Yann, Bessede, Thomas, Bouhié, Sébastien, Boutin, Jean-Marie, Caillet, Kevin, Cognard, Noelle, Culty, Thibaut, De Fortescu, Guillaume, Drouin, Sarah, Bentellis, Imad, Hubert, Jacques, Boissier, Romain, Sallusto, Federico, Sénéchal, Cédric, Terrier, Nicolas, Thuret, Rodolphe, Verhoest, Gregory, Waeckel, Thibaut, and Tillou, Xavier

Published
2023
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36. Impaired hippocampal neurogenesis in vitro is modulated by dietary-related endogenous factors and associated with depression in a longitudinal ageing cohort study

Author

Du Preez, Andrea, Lefèvre-Arbogast, Sophie, González-Domínguez, Raúl, Houghton, Vikki, de Lucia, Chiara, Low, Dorrain Y., Helmer, Catherine, Féart, Catherine, Delcourt, Cécile, Proust-Lima, Cécile, Pallàs, Mercè, Sánchez-Pla, Alex, Urpi-Sardà, Mireia, Ruigrok, Silvie R., Altendorfer, Barbara, Aigner, Ludwig, Lucassen, Paul J., Korosi, Aniko, Manach, Claudine, Andres-Lacueva, Cristina, Samieri, Cécilia, and Thuret, Sandrine

Published
2022
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38. From bite to brain: Neuro‐immune interactions in food allergy.

Author

Houghton, Vikki, Eiwegger, Thomas, Florsheim, Esther Borges, Knibb, Rebecca C., Thuret, Sandrine, and Santos, Alexandra F.

Subjects
FOOD allergy, IMMUNOGLOBULIN E, MAST cells, SYMPTOMS, DIAGNOSIS
Abstract

Immunoglobulin E (IgE)‐mediated food allergies are reported to affect around 3.5% of children and 2.4% of adults, with symptoms varying in range and severity. While being the gold standard for diagnosis, oral food challenges are burdensome, and diagnostic tools based on specific IgE can be flawed. Furthering our understanding of the mechanisms behind food allergy onset, severity and persistence could help reveal immune profiles associated with the disease, to ultimately aid in diagnosis. Alterations to cytokine levels and immune cell ratios have been identified, though further research is needed to fully capture the heterogenous nature of food allergy. Moreover, the existence of such immune alterations also raises the question of potential wider systemic effects. For example, recent research has emphasised the existence and impact of neuro‐immune interactions and implicated behavioural and neurological changes associated with food allergy. This review will provide an overview of such food allergy‐driven neuro‐immune interactions, with the aim of emphasising the importance of furthering our understanding of the immune mechanisms underlying IgE‐mediated food allergy. [ABSTRACT FROM AUTHOR]

Published
2024
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45. Apolipoprotein E and sex modulate fatty acid metabolism in a prospective observational study of cognitive decline

Author

González-Domínguez, Raúl, Castellano-Escuder, Pol, Lefèvre-Arbogast, Sophie, Low, Dorrain Y., Du Preez, Andrea, Ruigrok, Silvie R., Lee, Hyunah, Helmer, Catherine, Pallàs, Mercè, Urpi-Sarda, Mireia, Sánchez-Pla, Alex, Korosi, Aniko, Lucassen, Paul J., Aigner, Ludwig, Manach, Claudine, Thuret, Sandrine, Samieri, Cécilia, and Andres-Lacueva, Cristina

Published
2022
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50. Restoring miR-132 expression rescues adult hippocampal neurogenesis and memory deficits in Alzheimer’s disease

Author

Walgrave, Hannah, Balusu, Sriram, Snoeck, Sarah, Vanden Eynden, Elke, Craessaerts, Katleen, Thrupp, Nicky, Wolfs, Leen, Horré, Katrien, Fourne, Yannick, Ronisz, Alicja, Silajdžić, Edina, Penning, Amber, Tosoni, Giorgia, Callaerts-Vegh, Zsuzsanna, D’Hooge, Rudi, Thal, Dietmar Rudolf, Zetterberg, Henrik, Thuret, Sandrine, Fiers, Mark, Frigerio, Carlo Sala, De Strooper, Bart, and Salta, Evgenia

Published
2021
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