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13. Characteristics and treatment options of glucagonomas: a national study from the French Group of Endocrine Tumors and ENDOCAN-RENATEN network

Author

Perrier, Marine, primary, Brugel, Mathias, additional, Gérard, Laura, additional, Goichot, Bernard, additional, Lièvre, Astrid, additional, Lepage, Come, additional, Hautefeuille, Vincent, additional, Do Cao, Christine, additional, Smith, Denis, additional, Thuillier, Philippe, additional, Cros, Jérôme, additional, Cadiot, Guillaume, additional, Walter, Thomas, additional, and de Mestier, Louis, additional

Published
2023
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14. Genetic testing in prolactinomas: a cohort study

Author

Boukerrouni, Amina, primary, Cuny, Thomas, additional, Anjou, Thibaut, additional, Raingeard, Isabelle, additional, Ferrière, Amandine, additional, Grunenwald, Solange, additional, Maïza, Jean-Christophe, additional, Marquant, Emeline, additional, Sahakian, Nicolas, additional, Fodil-Cherif, Sarah, additional, Salle, Laurence, additional, Niccoli, Patricia, additional, Randrianaivo, Hanitra, additional, Sonnet, Emmanuel, additional, Chevalier, Nicolas, additional, Thuillier, Philippe, additional, Vezzosi, Delphine, additional, Reynaud, Rachel, additional, Dufour, Henry, additional, Brue, Thierry, additional, Tabarin, Antoine, additional, Delemer, Brigitte, additional, Kerlan, Véronique, additional, Castinetti, Frédéric, additional, Barlier, Anne, additional, and Romanet, Pauline, additional

Published
2023
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21. Case Report: Longterm metabolic response of metastatic uveal melanoma to pembrolizumab on FDG-PET/CT despite a serial pseudoprogressions phenomenon.

Author

Amrane, Karim, Le Meur, Coline, Thuillier, Philippe, Kamga, Jacques Dzuko, Alemany, Pierre, Chauvelot, Frederic, Niel, Clémence, Bellange, Alex, and Abgral, Ronan

Subjects
UVEA cancer, POSITRON emission tomography, PEMBROLIZUMAB, MELANOMA, METASTASIS, IMMUNE checkpoint inhibitors
Abstract

Uveal melanoma (UV) is a rare and aggressive melanoma with poor 1-year survival. up to 50% of UV patients develop metastases, mainly to the liver. Here, the authors present a 2-deoxy-2-[18F] fluoro-D-glucose positron emission tomography (18F-FDG-PET) study of a very rare case of secondarily metastatic UV in an 81-year-old Caucasian with a dramatic response to pembrolizumab associated with serial pseudogression. 18F-FDG-PET associated with clinical status and peripheral blood derived neutrophil-tolymphocyte ratio (dNLR) were performed to guide therapeutic strategy due to an atypical pseudoprogression phenomenon. [ABSTRACT FROM AUTHOR]

Published
2023
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23. Supplementary Figure 1 from Cytogenetic Instability in Ovarian Epithelial Cells from Women at Risk of Ovarian Cancer

Author

Pejovic, Tanja, primary, Yates, Jane E., primary, Liu, Hong Y., primary, Hays, Laura E., primary, Akkari, Yassmine, primary, Torimaru, Yumi, primary, Keeble, Winifred, primary, Rathbun, R. Keaney, primary, Rodgers, William H., primary, Bale, Allen E., primary, Ameziane, Najim, primary, Zwaan, C. Michael, primary, Errami, Abdellatif, primary, Thuillier, Philippe, primary, Cappuccini, Fabio, primary, Olson, Susan B., primary, Cain, Joanna M., primary, and Bagby, Grover C., primary

Published
2023
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24. Data from Cytogenetic Instability in Ovarian Epithelial Cells from Women at Risk of Ovarian Cancer

Author

Pejovic, Tanja, primary, Yates, Jane E., primary, Liu, Hong Y., primary, Hays, Laura E., primary, Akkari, Yassmine, primary, Torimaru, Yumi, primary, Keeble, Winifred, primary, Rathbun, R. Keaney, primary, Rodgers, William H., primary, Bale, Allen E., primary, Ameziane, Najim, primary, Zwaan, C. Michael, primary, Errami, Abdellatif, primary, Thuillier, Philippe, primary, Cappuccini, Fabio, primary, Olson, Susan B., primary, Cain, Joanna M., primary, and Bagby, Grover C., primary

Published
2023
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25. Supplementary Figure 2 from Cytogenetic Instability in Ovarian Epithelial Cells from Women at Risk of Ovarian Cancer

Author

Pejovic, Tanja, primary, Yates, Jane E., primary, Liu, Hong Y., primary, Hays, Laura E., primary, Akkari, Yassmine, primary, Torimaru, Yumi, primary, Keeble, Winifred, primary, Rathbun, R. Keaney, primary, Rodgers, William H., primary, Bale, Allen E., primary, Ameziane, Najim, primary, Zwaan, C. Michael, primary, Errami, Abdellatif, primary, Thuillier, Philippe, primary, Cappuccini, Fabio, primary, Olson, Susan B., primary, Cain, Joanna M., primary, and Bagby, Grover C., primary

Published
2023
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26. Supplementary Figure Legends and Tables 1-2 from Cytogenetic Instability in Ovarian Epithelial Cells from Women at Risk of Ovarian Cancer

Author

Pejovic, Tanja, primary, Yates, Jane E., primary, Liu, Hong Y., primary, Hays, Laura E., primary, Akkari, Yassmine, primary, Torimaru, Yumi, primary, Keeble, Winifred, primary, Rathbun, R. Keaney, primary, Rodgers, William H., primary, Bale, Allen E., primary, Ameziane, Najim, primary, Zwaan, C. Michael, primary, Errami, Abdellatif, primary, Thuillier, Philippe, primary, Cappuccini, Fabio, primary, Olson, Susan B., primary, Cain, Joanna M., primary, and Bagby, Grover C., primary

Published
2023
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32. Population-based input function (PBIF) applied to dynamic whole-body 68Ga-DOTATOC-PET/CT acquisition

Author

Thuillier, Philippe, primary, Bourhis, David, additional, Pavoine, Mathieu, additional, Metges, Jean-Philippe, additional, Le Pennec, Romain, additional, Schick, Ulrike, additional, Blanc-Béguin, Frédérique, additional, Hennebicq, Simon, additional, Salaun, Pierre-Yves, additional, Kerlan, Véronique, additional, Karakatsanis, Nicolas A., additional, and Abgral, Ronan, additional

Published
2022
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36. Prognostic Value of Whole-Body PET Volumetric Parameters Extracted from 68Ga-DOTATOC PET/CT in Well-Differentiated Neuroendocrine Tumors

Author

Thuillier, Philippe, primary, Liberini, Virginia, additional, Grimaldi, Serena, additional, Rampado, Osvaldo, additional, Gallio, Elena, additional, Santi, Bruno De, additional, Arvat, Emanuela, additional, Piovesan, Alessandro, additional, Filippi, Roberto, additional, Abgral, Ronan, additional, Molinari, Filippo, additional, and Deandreis, Désirée, additional

Published
2021
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37. Sex disparities in COVID-19 outcomes of inpatients with diabetes: insights from the CORONADO study

Author

Tramunt, Blandine, primary, Smati, Sarra, additional, Coudol, Sandrine, additional, Wargny, Matthieu, additional, Pichelin, Matthieu, additional, Guyomarch, Béatrice, additional, Al-Salameh, Abdallah, additional, Amadou, Coralie, additional, Barraud, Sara, additional, Bigot, Edith, additional, Bordier, Lyse, additional, Borot, Sophie, additional, Bourgeon, Muriel, additional, Bourron, Olivier, additional, Charrière, Sybil, additional, Chevalier, Nicolas, additional, Cosson, Emmanuel, additional, Fève, Bruno, additional, Flaus-Furmaniuk, Anna, additional, Fontaine, Pierre, additional, Galioot, Amandine, additional, Gonfroy-Leymarie, Céline, additional, Guerci, Bruno, additional, Lablanche, Sandrine, additional, Lalau, Jean-Daniel, additional, Larger, Etienne, additional, Lasbleiz, Adèle, additional, Laviolle, Bruno, additional, Marre, Michel, additional, Munch, Marion, additional, Potier, Louis, additional, Prevost, Gaëtan, additional, Renard, Eric, additional, Reznik, Yves, additional, Seret-Bégué, Dominique, additional, Sibilia, Paul, additional, Thuillier, Philippe, additional, Vergès, Bruno, additional, Gautier, Jean-François, additional, Hadjadj, Samy, additional, Cariou, Bertrand, additional, Mauvais-Jarvis, Franck, additional, and Gourdy, Pierre, additional

Published
2021
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38. Additional file 1 of Impact of segmentation and discretization on radiomic features in 68Ga-DOTA-TOC PET/CT images of neuroendocrine tumor

Author

Liberini, Virginia, Santi, Bruno De, Rampado, Osvaldo, Gallio, Elena, Dionisi, Beatrice, Ceci, Francesco, Polverari, Giulia, Thuillier, Philippe, Molinari, Filippo, and Deandreis, Désirée

Abstract

Additional file 1: Table S1. LifeX radiomic features description according to the Imaging Biomarker Standardization Initiative (IBSI) description (update 17 December 2019). LifeX version was 4.81. Figure S1. Box plots showing the distribution of SUVmax (panel A) and Volume (panel B). Figure S2. (A) Bar diagrams of intra-class correlation coefficient (ICC) values of RFs for robustness to SUVmax thresholding. Bars show the median ICC between the different segmentations for the absolute intensity rescale factor AR60. Range error bars (in black) encompass the lowest and highest values for different operators. (B) Boxplot of COVL for different threshold (20, 30, 40%) for each RFs, for the first operator (results superposable for the other operators). TLG (total lesion glycolysis) conventional parameter in our study corresponds to the TLSRE (total lesion somatostatin receptor expression). Figure S3. Radiomic features with moderate or poor consistency (ICC < 0.80), but high agreement (median COVL < 10%) to intensity discretization. The RFs were: GLCM_Entropy_log2, GLCM_Entropy_log10 (not shown), GLRLM_SRE, GLRLM_LRE and GLRLM_RP. Value of the RFs for each lesion are presented in the top row; boxplots of COVL for the first operator are presented in the bottom row. Figure S4. Radiomic features with high consistency (ICC > 0.90), but low agreement (median COVL > 10%) to SUVmax thresholds (0, 20, 30 and 40%). The RFs were: GLRLM_LGRE, GLRLM_SRLGE, GLZLM_LGZE and GLZLM_LZLGE. Value of the RFs for each lesion are presented in the top row; boxplots of COVL for the first operator are presented in the bottom row. Figure S5. Boxplot showing the distribution of RF value for each operator. The three RFs chosen are the most representative of the impact of segmentation on ICC. Segmentation did not affect SUVmean (A) and TLG (B) in terms of ICC, although TLG was characterized by not negligible dispersion (percentage of COVL) in our study. In contrast, segmentation had a high impact on GLZLM_SZLGE (C) in terms of both ICC and COVL. Mean COVL of SUVmean, TLG and GLZLM_SZLGE was 8.33±3.96, 13.38±8.52 and 30.67±27.29, respectively.

Published
2021
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39. Bed bug infestation in a French university hospital: control strategy, financial impact and perspectives.

Author

Gressier, A., Galakhoff, N., Thuillier, P., Kerlan, V., Cogulet, V., Cosse, M., Daniel, L., Canevet, M., Cabon, S., Le Grand, A., Baron, R., Saliou, P., Gressier, Annabelle, Galakhoff, Nicolas, Thuillier, Philippe, Kerlan, Véronique, Cogulet, Virginie, Cosse, Morgane, Daniel, Lénaïg, and Canevet, Maryline

Abstract

Background: With the increase in international travel and development of insecticide resistance, a re-emergence of the bed bug has been observed since the 2000s and it is becoming a worldwide public health problem. Hospitals and other medical settings have not been spared, while the cases reported remain limited. However, there are no specific recommendations for the healthcare settings in the literature.Aim: To report our experience of a bed bug infestation in a medical unit, in the French University Hospital Centre of Brest, caused by the admission of a patient carrier in October 2020. We described the practical methods used to control bed bugs infestation, evaluated the cost of this episode and created a specific procedure to take care of at-risk patients or known carriers of bed bugs.Findings: The decision to close the unit for global treatment was taken after the investigations using a sniffer dog revealed that four rooms were infested. The closure lasted 24 days. We estimated the total cost of the infestation to be approximately US$400,000. No other wave of infestation occurred. We created a specific protocol of care for patients who were known carriers or at risk of carriage of bed bugs to graduate a strategy of control.Conclusion: Bed bug infestations in health facilities have a major impact on the care of patients and relevant economic consequences. Prevention and education policies are an essential starting point to respond to the scale of the phenomenon. [ABSTRACT FROM AUTHOR]

Published
2022
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41. Diagnostic Value of Conventional PET Parameters and Radiomic Features Extracted from 18F-FDG-PET/CT for Histologic Subtype Classification and Characterization of Lung Neuroendocrine Neoplasms

Author

Thuillier, Philippe, primary, Liberini, Virginia, additional, Rampado, Osvaldo, additional, Gallio, Elena, additional, De Santi, Bruno, additional, Ceci, Francesco, additional, Metovic, Jasna, additional, Papotti, Mauro, additional, Volante, Marco, additional, Molinari, Filippo, additional, and Deandreis, Désirée, additional

Published
2021
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43. 68Ga-DOTATOC PET/CT-Based Radiomic Analysis and PRRT Outcome: A Preliminary Evaluation Based on an Exploratory Radiomic Analysis on Two Patients

Author

Liberini, Virginia, primary, Rampado, Osvaldo, additional, Gallio, Elena, additional, De Santi, Bruno, additional, Ceci, Francesco, additional, Dionisi, Beatrice, additional, Thuillier, Philippe, additional, Ciuffreda, Libero, additional, Piovesan, Alessandro, additional, Fioroni, Federica, additional, Versari, Annibale, additional, Molinari, Filippo, additional, and Deandreis, Désirée, additional

Published
2021
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44. Conjugated linoleic acid supplementation for twelve weeks increases lean body mass in obese humans

Author

Steck, Susan E., Chalecki, Allison M., Miller, Paul, Conway, Jason, Austin, Gregory L., Hardin, James W., Albright, Craig D., and Thuillier, Philippe

Subjects
Linoleic acids -- Analysis, Overweight persons -- Health aspects, Food/cooking/nutrition
Abstract

Conjugated linoleic acid (CLA) alters body composition in animal models, but few studies have examined the effects of CLA supplementation on body composition and clinical safety measures in obese humans. In the present study, we performed a randomized, double-blind, placebo-controlled trial to examine the changes in body composition and clinical laboratory values following CLA (50:50 ratio of cis-9, trans-11 and trans-10, cis-12 isomers) supplementation for 12 wk in otherwise healthy obese humans. Forty-eight participants (13 males and 35 females) were randomized to receive placebo (8 g safflower oil/d), 3.2 g/d CLA, or 6.4 g/d CLA for 12 wk. Changes in body fat mass and lean body mass were determined by dual-energy X-ray absorptiometry. Resting energy expenditure was assessed by indirect calorimetry. Clinical laboratory values and adverse-event reporting were used to monitor safety. Lean body mass increased by 0.64 kg in the 6.4 g/d CLA group (P < 0.05) after 12 wk of intervention. Significant decreases in serum HDL-cholesterol and sodium, hemoglobin, and hematocrit, and significant increases in serum alkaline phosphatase, C-reactive protein, and IL-6, and white blood cells occurred in the 6.4 g/d CLA group, although all values remained within normal limits. The intervention was well tolerated and no severe adverse events were reported, although mild gastrointestinal adverse events were reported in all treatment groups. In conclusion, whereas CLA may increase lean body mass in obese humans, it may also increase markers of inflammation in the short term.

Published
2007

45. Optimisation des paramètres de quantification en imagerie TEP pour le diagnostic, l'évaluation thérapeuthique et le pronostic des cancers endocriniens

Author

Thuillier, Philippe, Groupe d'Etude de la Thrombose de Bretagne Occidentale (GETBO), Université de Brest (UBO)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO)-Université de Brest (UBO), Université de Bretagne occidentale - Brest, Véronique Kerlan, and Ronan Abgral

Subjects
Tumeurs neuroendocrines, PET / CT, Dynamic acquisition, Fhyroid incidentaloma, Quantification, Incidentalome thyroïdien focal, Tumeurs surrénaliennes, Adrenal tumors, Neuroendocrine tumors, Acquisition dynamique, TEP/TDM, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

The objective of this work was to propose a systematic and reasoned approach of the quantification tools available in clinical routine and in research in the management of patients with endocrine tumors. Our results report the limitations of semi-quantitative parameters to assess the malignancy of fTI detected by 18FDG-PET / CT. Our data on the interest of textural parameters in the diagnosis of malignancy of adrenal tumors show excellent performances of these indices. However these indices do not appear superior in comparison with conventional semi-quantitative parameters.Our approach raises new hypotheses regarding the interest of texture analysis in the characterization of some rare adrenal tumors (pheochromocytomas and adrenocortical carcinoma) that will be the subject of future work. Finally, our work on the multi-parametric 68Ga-DOTATOC-PET / CT imaging highlights the feasibility of a whole-body dynamic 68Ga-DOTATOC-PET / CT acquisition and the possibilities to perform quantification of NETs uptake treated with PRRT on post-therapeutic SPECT / CT acquisitions. Our results open up multiple perspectives for the management of NETs at different stages of the disease (diagnosis, prognosis and therapeutic evaluation).; L’objectif de ce travail de thèse était de proposer une approche systématique et raisonnée des outils de quantification disponibles en routine clinique et du domaine de la recherche dans la prise en charge des patients atteints d’une tumeur endocrine. Nos résultats font état des limites des paramètres semi-quantitatifs pour faire le diagnostic de malignité d’un ITf fixant au 18FDG-TEP/TDM. Nos données sur l’intérêt des paramètres de textures dans le diagnostic de malignité des tumeurs surrénaliennes nous montrent des performances excellentes de ces indices mais qui n’apparaissent cependant pas supérieures en comparaison des paramètres semi-quantitatifs conventionnels. Notre approche soulève de nouvelles hypothèses quant à l’intérêt de l’analyse de texture dans la caractérisation de certaines tumeurs surrénaliennes rares (phéochromocytomes et corticosurrenalomes) qui devront faire l’objet de futurs travaux. Enfin, notre travail sur l’approche multi-paramétrique en imagerie 68Ga-DOTATOC-TEP/TDM met en évidence la faisabilité d’une acquisition dynamique corps entier en 68Ga-DOTATOC-TEP/TDM et les possibilités de quantification de la fixation tumorale des TNE traitées par RIV sur les acquisitions TEMP/TDM post-thérapeutiques. Nos résultats ouvrent des perspectives multiples quant à la prise en charge des TNE à différents étapes de la maladie (diagnostique, pronostique et évaluation thérapeutique).

Published
2019

47. The Challenge of Evaluating Response to Peptide Receptor Radionuclide Therapy in Gastroenteropancreatic Neuroendocrine Tumors: The Present and the Future

Author

Liberini, Virginia, primary, Huellner, Martin W., additional, Grimaldi, Serena, additional, Finessi, Monica, additional, Thuillier, Philippe, additional, Muni, Alfredo, additional, Pellerito, Riccardo E., additional, Papotti, Mauro G., additional, Piovesan, Alessandro, additional, Arvat, Emanuela, additional, and Deandreis, Désirée, additional

Published
2020
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48. Clinical Assessment of 177Lu-DOTATATE Quantification by Comparison of SUV-Based Parameters Measured on Both Post-PRRT SPECT/CT and 68Ga-DOTATOC PET/CT in Patients With Neuroendocrine Tumors

Author

Thuillier, Philippe, primary, Maajem, Meriem, additional, Schick, Ulrike, additional, Blanc-Beguin, Frédérique, additional, Hennebicq, Simon, additional, Metges, Jean-Philippe, additional, Salaun, Pierre-Yves, additional, Kerlan, Véronique, additional, Bourhis, David, additional, and Abgral, Ronan, additional

Published
2020
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