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5 results on '"Thoulass, Gudrun"'

1. Gene editing of hematopoietic stem cells restores T-cell response in familial hemophagocytic lymphohistiocytosis

Author

Dettmer-Monaco, Viviane, Weißert, Kristoffer, Ammann, Sandra, Monaco, Gianni, Lei, Lei, Gräßel, Linda, Rhiel, Manuel, Rositzka, Julia, Kaufmann, Masako M., Geiger, Kerstin, Andrieux, Geoffroy, Lao, Jessica, Thoulass, Gudrun, Schell, Christoph, Boerries, Melanie, Illert, Anna L., Cornu, Tatjana I., Ehl, Stephan, Aichele, Peter, and Cathomen, Toni

Published
2024
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2. Correction: Patients and mice with deficiency in the SNARE protein SYNTAXIN-11 have a secondary B cell defect

Author

Kögl, Tamara, primary, Chang, Hsin-Fang, additional, Staniek, Julian, additional, Chiang, Samuel C.C., additional, Thoulass, Gudrun, additional, Lao, Jessica, additional, Weißert, Kristoffer, additional, Dettmer-Monaco, Viviane, additional, Geiger, Kerstin, additional, Manna, Paul T., additional, Beziat, Vivien, additional, Momenilandi, Mana, additional, Tu, Szu-Min, additional, Keppler, Selina J., additional, Pattu, Varsha, additional, Wolf, Philipp, additional, Kupferschmid, Laurence, additional, Tholen, Stefan, additional, Covill, Laura E., additional, Ebert, Karolina, additional, Straub, Tobias, additional, Groß, Miriam, additional, Gather, Ruth, additional, Engel, Helena, additional, Salzer, Ulrich, additional, Schell, Christoph, additional, Maier, Sarah, additional, Lehmberg, Kai, additional, Cornu, Tatjana I., additional, Pircher, Hanspeter, additional, Shahrooei, Mohammad, additional, Parvaneh, Nima, additional, Elling, Roland, additional, Rizzi, Marta, additional, Bryceson, Yenan T., additional, Ehl, Stephan, additional, Aichele, Peter, additional, and Ammann, Sandra, additional

Published
2024
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3. Patients and mice with deficiency in the SNARE protein SYNTAXIN-11 have a secondary B cell defect

Author

Kögl, Tamara, primary, Chang, Hsin-Fang, additional, Staniek, Julian, additional, Chiang, Samuel C.C., additional, Thoulass, Gudrun, additional, Lao, Jessica, additional, Weißert, Kristoffer, additional, Dettmer-Monaco, Viviane, additional, Geiger, Kerstin, additional, Manna, Paul T., additional, Beziat, Vivien, additional, Momenilandi, Mana, additional, Tu, Szu-Min, additional, Keppler, Selina J., additional, Pattu, Varsha, additional, Wolf, Philipp, additional, Kupferschmid, Laurence, additional, Tholen, Stefan, additional, Covill, Laura E., additional, Ebert, Karolina, additional, Straub, Tobias, additional, Groß, Miriam, additional, Gather, Ruth, additional, Engel, Helena, additional, Salzer, Ulrich, additional, Schell, Christoph, additional, Maier, Sarah, additional, Lehmberg, Kai, additional, Cornu, Tatjana I., additional, Pircher, Hanspeter, additional, Shahrooei, Mohammad, additional, Parvaneh, Nima, additional, Elling, Roland, additional, Rizzi, Marta, additional, Bryceson, Yenan T., additional, Ehl, Stephan, additional, Aichele, Peter, additional, and Ammann, Sandra, additional

Published
2024
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4. Gene editing of hematopoietic stem cells restores T cell response in familial hemophagocytic lymphohistiocytosis

Author

Dettmer-Monaco, Viviane, primary, Weißert, Kristoffer, additional, Ammann, Sandra, additional, Monaco, Gianni, additional, Lei, Lei, additional, Gräßel, Linda, additional, Rhiel, Manuel, additional, Rositzka, Julia, additional, Kaufmann, Masako M., additional, Geiger, Kerstin, additional, Andrieux, Geoffroy, additional, Lao, Jessica, additional, Thoulass, Gudrun, additional, Schell, Christoph, additional, Boerries, Melanie, additional, Illert, Anna Lena, additional, Cornu, Tatjana I., additional, Ehl, Stephan, additional, Aichele, Peter, additional, and Cathomen, Toni, additional

Published
2023
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5. The Microbiome Modifies Manifestations of Hemophagocytic Lymphohistiocytosis in Perforin-Deficient Mice.

Author

Mann J, Runge S, Schell C, Gräwe K, Thoulass G, Lao J, Ammann S, Grün S, König C, Berger SA, Hild B, Aichele P, Rosshart SP, and Ehl S

Abstract

Primary hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory syndrome caused by inborn errors of cytotoxicity. Patients with biallelic PRF1 null mutations (encoding perforin) usually develop excessive immune cell activation, hypercytokinemia, and life-threatening immunopathology in the first 6 months of life, often without an apparent infectious trigger. In contrast, perforin-deficient (PKO) mice only develop HLH after systemic infection with lymphocytic choriomeningitis virus (LCMV). We hypothesized that restricted microbe-immune cell interactions due to specific pathogen-free (SPF) housing might explain the need for this specific viral trigger in PKO mice. To investigate the influence of a "wild" microbiome in PKO mice, we fostered PKO newborns with Wildling microbiota ('PKO-Wildlings') and monitored them for signs of HLH. PKO-Wildlings survived long-term without spontaneous disease. Also, systemic infection with vaccinia virus did not reach the threshold of immune activation required to trigger HLH in PKO-Wildlings. Interestingly, after infection with LCMV, PKO-Wildlings developed an altered HLH pattern. This included lower IFN-γ serum levels along with improved IFN-γ-driven anemia, but more elevated levels of IL-17 and increased liver inflammation compared with PKO-SPF mice. Thus, wild microbiota alone is not sufficient to trigger HLH in PKO mice, but host-microbe interactions shape inflammatory cytokine patterns, thereby influencing manifestations of HLH immunopathology., (© 2024 The Author(s). European Journal of Immunology published by Wiley‐VCH GmbH.)

Published
2024
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