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7 results on '"Thorpe, Kathryn"'

4. Clinical and electrophysiological examination of pinch strength in patients with amyotrophic lateral sclerosis.

Author

Lee, John D., Heshmat, Saman, Heggie, Susan, Thorpe, Kathryn A., McCombe, Pamela A., and Henderson, Robert D.

Abstract

Background: The split‐hand concept has highlighted the preferential wasting of the thenar side of the hand in amyotrophic lateral sclerosis (ALS). Our objective is to re‐explore pinch grip strength to assess whether it has the potential to be a practical biomarker of ALS. Methods: We measured different pinch grip strengths (thumb, index, and fifth) using a pinch gauge from both hands of 54 ALS patients and correlated this with the Medical Research Council (MRC) score, the upper‐limb component of the revised ALS Functional Rating Scale – Revised (ALSFRS‐R) score, and compound muscle action potentials (CMAPs) that comprise the split‐hand index. Results: Pinch grip strength using any of the three fingers showed a positive correlation with its corresponding CMAP, MRC grading, and upper‐limb ALSFRS‐R score. The thumb pinch showed the strongest correlation with the split‐hand index and MRC grading. Conclusions: Pinch grip strength test using a simple gauge deserves further study as a potentially practical biomarker of ALS. [ABSTRACT FROM AUTHOR]

Published
2021
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5. Hypermetabolism in ALS is associated with greater functional decline and shorter survival

Author

Steyn, Frederik J, primary, Ioannides, Zara A, additional, van Eijk, Ruben P A, additional, Heggie, Susan, additional, Thorpe, Kathryn A, additional, Ceslis, Amelia, additional, Heshmat, Saman, additional, Henders, Anjali K, additional, Wray, Naomi R, additional, van den Berg, Leonard H, additional, Henderson, Robert D, additional, McCombe, Pamela A, additional, and Ngo, Shyuan T, additional

Published
2018
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6. Whole exome sequencing and DNA methylation analysis in a clinical amyotrophic lateral sclerosis cohort

Author

Garton, Fleur C., primary, Benyamin, Beben, additional, Zhao, Qiongyi, additional, Liu, Zhijun, additional, Gratten, Jacob, additional, Henders, Anjali K., additional, Zhang, Zong-Hong, additional, Edson, Janette, additional, Furlong, Sarah, additional, Morgan, Sarah, additional, Heggie, Susan, additional, Thorpe, Kathryn, additional, Pfluger, Casey, additional, Mather, Karen A., additional, Sachdev, Perminder S., additional, McRae, Allan F., additional, Robinson, Matthew R., additional, Shah, Sonia, additional, Visscher, Peter M., additional, Mangelsdorf, Marie, additional, Henderson, Robert D., additional, Wray, Naomi R., additional, and McCombe, Pamela A., additional

Published
2017
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