Search

An in vivo animal model of a weight‐bearing intra‐articular implant is crucial to the study of implant osseointegration and aseptic loosening caused by osseointegration failure. Osseointegration, defined as a direct structural and functional attachment between living bone tissue and the surface of a load‐carrying implant, is essential for implant stability and considered a prerequisite for the long‐term clinical success of implants in total joint arthroplasty. Compared to large animal models, murine models offer extensive genetic tools for tracing cell differentiation and proliferation. The 18‐ to 22‐week‐old C57BL/6J background mice underwent either press‐fitted or loose implantation of a titanium implant, achieving osseointegration or fibrous integration. A protocol was developed for both versions of the procedure, including a description of the relevant anatomy. Samples were subjected to microcomputed tomography and underwent biomechanical testing to access osseointegration. Lastly, samples were fixed and embedded for histological evaluation. The absence of mineralized tissue and weakened maximum pull‐out force in loose implantation samples indicated that these implants were less mechanically stable compared to the control at 4 weeks postoperation. Histological analysis demonstrated extensive fibrotic tissue in the peri‐implant area of loose implantation samples and excellent implant osseointegration in press‐fitted samples at 4 weeks. Both mechanically stable and unstable hemiarthroplasty models with either osseous ingrowth or a robust periprosthetic fibrosis were achieved in mice. We hope that this model can help address current limitations for in vivo study of aseptic loosening and lead to necessary translational benefits. [ABSTRACT FROM AUTHOR]

Responding to burgeoning scholarship examining discrete positive emotions, the overarching goals of the current review are to provide a summary of 28 enjoyable emotions and to offer an initial classification of these emotions into families. The families of discrete enjoyable emotions, many proposed for the first time, are as follows: (1) Self-praising emotions (authentic pride, fiero, naches, feeling respected), (2) other-praising emotions (admiration, elevation, gratitude, inspiration), (3) past-oriented emotions (forgiveness, nostalgia, relief), (4) future-oriented emotions (anticipatory enthusiasm, courage, determination, hope), (5) hazardous emotions (lust, schadenfreude, hubristic pride), (6) affectionate emotions (love, attachment love, tenderness, positive empathy), (7) arousal-defined emotions (euphoria, serenity), (8) violation-elicited emotions (amusement, awe, curiosity, positive surprise).This review describes how the 28 enjoyable emotions were selected, outlines the classification process generating the families of enjoyable emotions, provides a brief summary of current scholarship on each emotion, and concludes with a discussion of fertile future directions. [ABSTRACT FROM AUTHOR]

The term elevation (also referred to as moral elevation), described by Thomas Jefferson and later coined by Jonathan Haidt, refers to the suite of feelings people may experience when witnessing an instance of moral beauty. The construct of elevation signifies the emotion felt when a person is a witness to, but not a recipient of, the moral behavior of others. Scholarship examining elevation has burgeoned since Haidt first introduced the construct. Researchers have explored the antecedents of, and outcomes associated with, witnessing instances of moral beauty. The current review will outline the existing scholarship on elevation, highlight conflicting findings, point out critical gaps in the current state of elevation research, and delineate fertile future directions for basic and applied research. Continued investigation of the affective, motivational, and behavioral responses associated with witnessing virtuous actions of others is warranted. [ABSTRACT FROM AUTHOR]

Three online studies assessed a new approach for increasing help seeking among people with depressive symptomatology (i.e. a positive emotion infusion, PEI). A PEI refers to the induction of positive emotion such that people’s mindsets – including perceptions of help-seeking – are temporarily altered. Study 1 (n = 382) indicated that help-seeking intentions are negatively correlated with depressive symptomatology and positively correlated with elevation and gratitude. Studies 2 and 3 implemented fully randomized experimental designs. In Study 2, two elevation-based (Study 2a, n = 285) and two gratitude-based (Study 2b, n = 338) emotion inductions increased levels of elevation and gratitude, respectively. Results of Study 3a (n = 390) indicate a causal relationship between experiencing the story-based elevation induction and increased help-seeking intentions. The two gratitude-based PEIs (Study 3b, n = 466) were unsuccessful at influencing help-seeking; auxiliary analyses indicate the possibility of iatrogenic effects. Overall, the potential of PEIs was indicated, as was need for caution. [ABSTRACT FROM AUTHOR]

Elevation refers to the feeling experienced when a moral act is witnessed. The current study sought to illuminate elevation by examining conditions under which elevation is amplified. Study 1 demonstrated that the character of the recipient of the moral deed moderates the relationship between witnessing a moral deed and experiencing elevation. Study 2 replicated the first and included a behavioral outcome measure: donation behavior. Study 3 considered an additional factor: the immoral act. Finally, to ensure the character of the recipient is not the sole moderator, Study 4 experimentally tested a second moderating variable (i.e. the effort required for completing the moral act). As a whole, these four studies consistently support Haidt’s conceptualization of elevation, open the door for a new path of theoretical exploration, and introduce a new line of applied research seeking to maximize prosocial behavior by exposing people to acts of morality. [ABSTRACT FROM PUBLISHER]