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1. Large-scale differentiation of iPSC-derived motor neurons from ALS and control subjects

Author

Workman, Michael J, Lim, Ryan G, Wu, Jie, Frank, Aaron, Ornelas, Loren, Panther, Lindsay, Galvez, Erick, Perez, Daniel, Meepe, Imara, Lei, Susan, Valencia, Viviana, Gomez, Emilda, Liu, Chunyan, Moran, Ruby, Pinedo, Louis, Tsitkov, Stanislav, Ho, Ritchie, Kaye, Julia A, Consortium, the Answer ALS, Thompson, Terri, Rothstein, Jeffrey D, Finkbeiner, Steven, Fraenkel, Ernest, Sareen, Dhruv, Thompson, Leslie M, and Svendsen, Clive N

Subjects
Biomedical and Clinical Sciences, Neurosciences, Brain Disorders, Clinical Research, Stem Cell Research - Induced Pluripotent Stem Cell - Human, Rare Diseases, Stem Cell Research - Induced Pluripotent Stem Cell, Regenerative Medicine, Genetics, Neurodegenerative, Stem Cell Research, ALS, Orphan Drug, Neurological, Humans, Amyotrophic Lateral Sclerosis, Induced Pluripotent Stem Cells, Motor Neurons, Cell Differentiation, Answer ALS Consortium, iPSC, motor neurons, sex differences, Psychology, Cognitive Sciences, Neurology & Neurosurgery, Biological psychology
Abstract

Using induced pluripotent stem cells (iPSCs) to understand the mechanisms of neurological disease holds great promise; however, there is a lack of well-curated lines from a large array of participants. Answer ALS has generated over 1,000 iPSC lines from control and amyotrophic lateral sclerosis (ALS) patients along with clinical and whole-genome sequencing data. The current report summarizes cell marker and gene expression in motor neuron cultures derived from 92 healthy control and 341 ALS participants using a 32-day differentiation protocol. This is the largest set of iPSCs to be differentiated into motor neurons, and characterization suggests that cell composition and sex are significant sources of variability that need to be carefully controlled for in future studies. These data are reported as a resource for the scientific community that will utilize Answer ALS data for disease modeling using a wider array of omics being made available for these samples.

Published
2023

4. Answer ALS, a large-scale resource for sporadic and familial ALS combining clinical and multi-omics data from induced pluripotent cell lines

Author

Baxi, Emily G, Thompson, Terri, Li, Jonathan, Kaye, Julia A, Lim, Ryan G, Wu, Jie, Ramamoorthy, Divya, Lima, Leandro, Vaibhav, Vineet, Matlock, Andrea, Frank, Aaron, Coyne, Alyssa N, Landin, Barry, Ornelas, Loren, Mosmiller, Elizabeth, Thrower, Sara, Farr, S Michelle, Panther, Lindsey, Gomez, Emilda, Galvez, Erick, Perez, Daniel, Meepe, Imara, Lei, Susan, Mandefro, Berhan, Trost, Hannah, Pinedo, Louis, Banuelos, Maria G, Liu, Chunyan, Moran, Ruby, Garcia, Veronica, Workman, Michael, Ho, Richie, Wyman, Stacia, Roggenbuck, Jennifer, Harms, Matthew B, Stocksdale, Jennifer, Miramontes, Ricardo, Wang, Keona, Venkatraman, Vidya, Holewenski, Ronald, Sundararaman, Niveda, Pandey, Rakhi, Manalo, Danica-Mae, Donde, Aneesh, Huynh, Nhan, Adam, Miriam, Wassie, Brook T, Vertudes, Edward, Amirani, Naufa, Raja, Krishna, Thomas, Reuben, Hayes, Lindsey, Lenail, Alex, Cerezo, Aianna, Luppino, Sarah, Farrar, Alanna, Pothier, Lindsay, Prina, Carolyn, Morgan, Todd, Jamil, Arish, Heintzman, Sarah, Jockel-Balsarotti, Jennifer, Karanja, Elizabeth, Markway, Jesse, McCallum, Molly, Joslin, Ben, Alibazoglu, Deniz, Kolb, Stephen, Ajroud-Driss, Senda, Baloh, Robert, Heitzman, Daragh, Miller, Tim, Glass, Jonathan D, Patel-Murray, Natasha Leanna, Yu, Hong, Sinani, Ervin, Vigneswaran, Prasha, Sherman, Alexander V, Ahmad, Omar, Roy, Promit, Beavers, Jay C, Zeiler, Steven, Krakauer, John W, Agurto, Carla, Cecchi, Guillermo, Bellard, Mary, Raghav, Yogindra, Sachs, Karen, Ehrenberger, Tobias, Bruce, Elizabeth, Cudkowicz, Merit E, Maragakis, Nicholas, Norel, Raquel, Van Eyk, Jennifer E, Finkbeiner, Steven, Berry, James, Sareen, Dhruv, Thompson, Leslie M, Fraenkel, Ernest, and Svendsen, Clive N

Subjects
Stem Cell Research, Rare Diseases, Stem Cell Research - Induced Pluripotent Stem Cell, ALS, Clinical Research, Neurodegenerative, Genetics, Neurosciences, Human Genome, Stem Cell Research - Induced Pluripotent Stem Cell - Human, Brain Disorders, Neurological, Generic health relevance, Good Health and Well Being, Amyotrophic Lateral Sclerosis, Cell Line, Humans, Induced Pluripotent Stem Cells, Motor Neurons, Psychology, Cognitive Sciences, Neurology & Neurosurgery
Abstract

Answer ALS is a biological and clinical resource of patient-derived, induced pluripotent stem (iPS) cell lines, multi-omic data derived from iPS neurons and longitudinal clinical and smartphone data from over 1,000 patients with ALS. This resource provides population-level biological and clinical data that may be employed to identify clinical-molecular-biochemical subtypes of amyotrophic lateral sclerosis (ALS). A unique smartphone-based system was employed to collect deep clinical data, including fine motor activity, speech, breathing and linguistics/cognition. The iPS spinal neurons were blood derived from each patient and these cells underwent multi-omic analytics including whole-genome sequencing, RNA transcriptomics, ATAC-sequencing and proteomics. The intent of these data is for the generation of integrated clinical and biological signatures using bioinformatics, statistics and computational biology to establish patterns that may lead to a better understanding of the underlying mechanisms of disease, including subgroup identification. A web portal for open-source sharing of all data was developed for widespread community-based data analytics.

Published
2022

7. An integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patients

Author

Consortium, The NeuroLINCS, Phatnani, Hemali, Kwan, Justin, Sareen, Dhruv, Broach, James R, Simmons, Zachary, Arcila-Londono, Ximena, Lee, Edward B, Van Deerlin, Vivianna M, Shneider, Neil A, Fraenkel, Ernest, Ostrow, Lyle W, Baas, Frank, Zaitlen, Noah, Berry, James D, Malaspina, Andrea, Fratta, Pietro, Cox, Gregory A, Thompson, Leslie M, Finkbeiner, Steve, Dardiotis, Efthimios, Miller, Timothy M, Chandran, Siddharthan, Pal, Suvankar, Hornstein, Eran, MacGowan, Daniel J, Heiman-Patterson, Terry, Hammell, Molly G, Patsopoulos, Nikolaos A, Butovsky, Oleg, Dubnau, Joshua, Nath, Avindra, Bowser, Robert, Harms, Matt, Poss, Mary, Phillips-Cremins, Jennifer, Crary, John, Atassi, Nazem, Lange, Dale J, Adams, Darius J, Stefanis, Leonidas, Gotkine, Marc, Baloh, Robert H, Babu, Suma, Raj, Towfique, Paganoni, Sabrina, Shalem, Ophir, Smith, Colin, Zhang, Bin, Harris, Brent, Broce, Iris, Drory, Vivian, Ravits, John, McMillan, Corey, Menon, Vilas, Wu, Lani, Altschuler, Steven, Li, Jonathan, Lim, Ryan G, Kaye, Julia A, Dardov, Victoria, Coyne, Alyssa N, Wu, Jie, Milani, Pamela, Cheng, Andrew, Thompson, Terri G, Ornelas, Loren, Frank, Aaron, Adam, Miriam, Banuelos, Maria G, Casale, Malcolm, Cox, Veerle, Escalante-Chong, Renan, Daigle, J Gavin, Gomez, Emilda, Hayes, Lindsey, Holewenski, Ronald, Lei, Susan, Lenail, Alex, Lima, Leandro, Mandefro, Berhan, Matlock, Andrea, Panther, Lindsay, Patel-Murray, Natasha Leanna, Pham, Jacqueline, Ramamoorthy, Divya, Sachs, Karen, Shelley, Brandon, Stocksdale, Jennifer, Trost, Hannah, Wilhelm, Mark, Venkatraman, Vidya, Wassie, Brook T, Wyman, Stacia, Yang, Stephanie, Consortium, NYGC ALS, Van Eyk, Jennifer E, Lloyd, Thomas E, and Finkbeiner, Steven

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Genetics, Neurodegenerative, Clinical Research, ALS, Stem Cell Research, Rare Diseases, Acquired Cognitive Impairment, Stem Cell Research - Induced Pluripotent Stem Cell, Brain Disorders, Neurosciences, Dementia, Stem Cell Research - Induced Pluripotent Stem Cell - Human, 2.1 Biological and endogenous factors, Aetiology, Neurological, Good Health and Well Being, NeuroLINCS Consortium, NYGC ALS Consortium, Biological sciences, Neuroscience, Omics, Systems biology, Systems neuroscience
Abstract

Neurodegenerative diseases are challenging for systems biology because of the lack of reliable animal models or patient samples at early disease stages. Induced pluripotent stem cells (iPSCs) could address these challenges. We investigated DNA, RNA, epigenetics, and proteins in iPSC-derived motor neurons from patients with ALS carrying hexanucleotide expansions in C9ORF72. Using integrative computational methods combining all omics datasets, we identified novel and known dysregulated pathways. We used a C9ORF72 Drosophila model to distinguish pathways contributing to disease phenotypes from compensatory ones and confirmed alterations in some pathways in postmortem spinal cord tissue of patients with ALS. A different differentiation protocol was used to derive a separate set of C9ORF72 and control motor neurons. Many individual -omics differed by protocol, but some core dysregulated pathways were consistent. This strategy of analyzing patient-specific neurons provides disease-related outcomes with small numbers of heterogeneous lines and reduces variation from single-omics to elucidate network-based signatures.

Published
2021

11. The Humanbecoming Concept Inventing Model: Another Exploration of Hope.

Author

Hamilton, Teresa, Thompson, Terri, Meyer, Rebecca, Anozie, Melissa, Dunkerley, Marion, Jetton, Susan, Toro, Stacey, and Bradley, Karen

Subjects
*HUMANISM, *NURSING models, *NURSING, *NURSES' attitudes, *CONCEPTUAL structures, *CONCEPTS, *HOPE
Abstract

In this paper, a community of eight aspiring Parse scholars presents experiences with a scholarly investigation using Parse's humanbecoming concept inventing model to discover the meaning of the nursing phenomenon hope as a universal humanuniverse living experience. The now-truth of the universal humanuniverse living experience hope surfaced as envisioning possibilities with sureness-unsureness arising with opportunities-restrictions. The ingenuous proclamation of hope, together with the aspiring Parse scholars' chosen artform, is declared as a theoretical statement at the level of the humanbecoming paradigm is imaging the originating of enabling-limiting. The contributions of aspiring Parse scholars offer opportunities to advance nursing knowledge of the universal humanuniverse living experience hope. [ABSTRACT FROM AUTHOR]

Published
2024
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12. The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations

Author

Keenan, Alexandra B, Jenkins, Sherry L, Jagodnik, Kathleen M, Koplev, Simon, He, Edward, Torre, Denis, Wang, Zichen, Dohlman, Anders B, Silverstein, Moshe C, Lachmann, Alexander, Kuleshov, Maxim V, Ma'ayan, Avi, Stathias, Vasileios, Terryn, Raymond, Cooper, Daniel, Forlin, Michele, Koleti, Amar, Vidovic, Dusica, Chung, Caty, Schürer, Stephan C, Vasiliauskas, Jouzas, Pilarczyk, Marcin, Shamsaei, Behrouz, Fazel, Mehdi, Ren, Yan, Niu, Wen, Clark, Nicholas A, White, Shana, Mahi, Naim, Zhang, Lixia, Kouril, Michal, Reichard, John F, Sivaganesan, Siva, Medvedovic, Mario, Meller, Jaroslaw, Koch, Rick J, Birtwistle, Marc R, Iyengar, Ravi, Sobie, Eric A, Azeloglu, Evren U, Kaye, Julia, Osterloh, Jeannette, Haston, Kelly, Kalra, Jaslin, Finkbiener, Steve, Li, Jonathan, Milani, Pamela, Adam, Miriam, Escalante-Chong, Renan, Sachs, Karen, Lenail, Alex, Ramamoorthy, Divya, Fraenkel, Ernest, Daigle, Gavin, Hussain, Uzma, Coye, Alyssa, Rothstein, Jeffrey, Sareen, Dhruv, Ornelas, Loren, Banuelos, Maria, Mandefro, Berhan, Ho, Ritchie, Svendsen, Clive N, Lim, Ryan G, Stocksdale, Jennifer, Casale, Malcolm S, Thompson, Terri G, Wu, Jie, Thompson, Leslie M, Dardov, Victoria, Venkatraman, Vidya, Matlock, Andrea, Van Eyk, Jennifer E, Jaffe, Jacob D, Papanastasiou, Malvina, Subramanian, Aravind, Golub, Todd R, Erickson, Sean D, Fallahi-Sichani, Mohammad, Hafner, Marc, Gray, Nathanael S, Lin, Jia-Ren, Mills, Caitlin E, Muhlich, Jeremy L, Niepel, Mario, Shamu, Caroline E, Williams, Elizabeth H, Wrobel, David, Sorger, Peter K, Heiser, Laura M, Gray, Joe W, Korkola, James E, Mills, Gordon B, LaBarge, Mark, Feiler, Heidi S, Dane, Mark A, Bucher, Elmar, Nederlof, Michel, Sudar, Damir, and Gross, Sean

Subjects
Bioengineering, Cancer, Genetics, Biotechnology, 2.1 Biological and endogenous factors, Aetiology, Generic health relevance, Good Health and Well Being, Cataloging, Computational Biology, Databases, Chemical, Gene Expression Profiling, Gene Library, Humans, Information Storage and Retrieval, National Health Programs, National Institutes of Health (U.S.), Systems Biology, Transcriptome, United States, BD2K, L1000, MCF10A, MEMA, P100, data integration, lincsprogram, lincsproject, systems biology, systems pharmacology, Biochemistry and Cell Biology
Abstract

The Library of Integrated Network-Based Cellular Signatures (LINCS) is an NIH Common Fund program that catalogs how human cells globally respond to chemical, genetic, and disease perturbations. Resources generated by LINCS include experimental and computational methods, visualization tools, molecular and imaging data, and signatures. By assembling an integrated picture of the range of responses of human cells exposed to many perturbations, the LINCS program aims to better understand human disease and to advance the development of new therapies. Perturbations under study include drugs, genetic perturbations, tissue micro-environments, antibodies, and disease-causing mutations. Responses to perturbations are measured by transcript profiling, mass spectrometry, cell imaging, and biochemical methods, among other assays. The LINCS program focuses on cellular physiology shared among tissues and cell types relevant to an array of diseases, including cancer, heart disease, and neurodegenerative disorders. This Perspective describes LINCS technologies, datasets, tools, and approaches to data accessibility and reusability.

Published
2018

13. An integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patients

Author

Phatnani, Hemali, Kwan, Justin, Sareen, Dhruv, Broach, James R., Simmons, Zachary, Arcila-Londono, Ximena, Lee, Edward B., Van Deerlin, Vivianna M., Shneider, Neil A., Fraenkel, Ernest, Ostrow, Lyle W., Baas, Frank, Zaitlen, Noah, Berry, James D., Malaspina, Andrea, Fratta, Pietro, Cox, Gregory A., Thompson, Leslie M., Finkbeiner, Steve, Dardiotis, Efthimios, Miller, Timothy M., Chandran, Siddharthan, Pal, Suvankar, Hornstein, Eran, MacGowan, Daniel J., Heiman-Patterson, Terry, Hammell, Molly G., Patsopoulos, Nikolaos.A., Butovsky, Oleg, Dubnau, Joshua, Nath, Avindra, Bowser, Robert, Harms, Matt, Poss, Mary, Phillips-Cremins, Jennifer, Crary, John, Atassi, Nazem, Lange, Dale J., Adams, Darius J., Stefanis, Leonidas, Gotkine, Marc, Baloh, Robert H., Babu, Suma, Raj, Towfique, Paganoni, Sabrina, Shalem, Ophir, Smith, Colin, Zhang, Bin, Harris, Brent, Broce, Iris, Drory, Vivian, Ravits, John, McMillan, Corey, Menon, Vilas, Wu, Lani, Altschuler, Steven, Li, Jonathan, Lim, Ryan G., Kaye, Julia A., Dardov, Victoria, Coyne, Alyssa N., Wu, Jie, Milani, Pamela, Cheng, Andrew, Thompson, Terri G., Ornelas, Loren, Frank, Aaron, Adam, Miriam, Banuelos, Maria G., Casale, Malcolm, Cox, Veerle, Escalante-Chong, Renan, Daigle, J. Gavin, Gomez, Emilda, Hayes, Lindsey, Holewenski, Ronald, Lei, Susan, Lenail, Alex, Lima, Leandro, Mandefro, Berhan, Matlock, Andrea, Panther, Lindsay, Patel-Murray, Natasha Leanna, Pham, Jacqueline, Ramamoorthy, Divya, Sachs, Karen, Shelley, Brandon, Stocksdale, Jennifer, Trost, Hannah, Wilhelm, Mark, Venkatraman, Vidya, Wassie, Brook T., Wyman, Stacia, Yang, Stephanie, Van Eyk, Jennifer E., Lloyd, Thomas E., Finkbeiner, Steven, Rothstein, Jeffrey D., and Svendsen, Clive N.

Published
2021
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17. Experiences with and unmet needs for medication abortion support: A qualitative study with US abortion support providers.

Author

Seymour, Jane W., Ruggiero, Samantha, Ranker, Lynsie, and Thompson, Terri‐Ann

Subjects
ABORTION laws, ABORTION in the United States, HEALTH services accessibility, MEDICAL quality control, OCCUPATIONAL roles, QUALITATIVE research, INTERVIEWING, PATIENT-centered care, THEMATIC analysis, TELEMEDICINE, ATTITUDES of medical personnel, RESEARCH methodology, NEEDS assessment, SOCIAL support
Abstract

Introduction: Quality abortion care must be person‐centered. Although academic literature has focused on full‐spectrum and abortion doulas supporting instrumentation abortion (also referred to as procedural abortion) clients, clients undergoing medication abortion remain understudied and may have unique needs. We aimed to understand United States (US) abortion support providers' perceptions of medication abortion clients' support needs by exploring which needs they address, which needs remain unmet, and how remote support provision might help address client needs. Methodology: Between April and October 2018, we conducted 60‐ to 90‐min semi‐structured, in‐depth interviews by telephone with medication abortion support providers. The interviews focused on their experiences providing support to medication abortion clients in the US. We used a deductive thematic analysis approach. Results: We interviewed 16 abortion support providers affiliated with nine US‐based organizations. Six participants provided in‐person support to medication abortion clients, five provided remote support, and five provided both remote and in‐person support. Both in‐person and remote providers described offering support that addressed clients' informational, emotional, physical, spiritual, and logistical needs. Through participant narratives, we identified interwoven benefits and challenges to remote support care provision. Participants highlighted that most medication abortion clients did not have a support provider. Discussion: Participants revealed that abortion support providers, including remote support providers, can be a critical component of high‐quality abortion care provision. More work is needed to ensure all abortion clients have access to support services as the abortion landscape in the US continues to evolve. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Recent Changes in New York Welfare and Work, Child Care, and Child Welfare Systems. State Update. Assessing the New Federalism: An Urban Institute Program To Assess Changing Social Policies.

Author

Urban Inst., Washington, DC., Fender, Lynne, O'Brien, Carolyn, Thompson, Terri, Snyder, Kathleen, and Bess, Roseana

Abstract

This brief updates "Income Support and Social Services for Low-Income People in New York," an overview of benefits and services in the state in 1997. Information comes from reviews of state and local program documents and interviews with selected officials responsible for policy and program operations in Erie County (Buffalo) and New York City. Most of the implementation of welfare reform occurred after the baseline visits that yielded the information presented in the earlier report. This brief describes the Family Assistance (FA) program, New York's version of Temporary Assistance for Needy Families, which represents a departure from the program described in the earlier report. Since 1997, New York has made many changes across the spectrum of social safety net programs. This brief concentrates on three areas of change: FA and workforce development, child care, and child welfare. The first section profiles New York's population; social, economic, and political conditions; the safety net; and changes in caseloads since 1997. The subsequent three sections describe in more detail current policies and recent changes in the areas of FA and workforce development, child care, and child welfare. The final section highlights other key changes in New York's safety net and their implications for understanding the effects of devolution and welfare reform. (SM)

Published
2002

23. Recent Changes in Washington Welfare and Work, Child Care, and Child Welfare Systems. State Update No. 6. Assessing the New Federalism: An Urban Institute Program To Assess Changing Social Policies.

Author

Urban Inst., Washington, DC., Thompson, Terri S., Snyder, Kathleen, Malm, Karin, and O'Brien, Carolyn

Abstract

This brief examines changes in Washington's welfare-to-work, child care, and child welfare systems since 1997, presenting information from visits to Washington in 1999 and 2000. It profiles Washington's demographic, economic, and political conditions, reviewing its income support and social services systems and highlighting recent changes, caseload statistics, and service organization. Three sections examine specific programs and services, describing the administrative structure, general service delivery, and policies affecting each program and program clients. The report describes Washington's Temporary Assistance for Needy Families (TANF) program, including the work-related component for TANF recipients and the overall workforce development system. It examines Washington's system for providing child care for both TANF and nonwelfare families. It also discusses the child welfare system, particularly the interaction between child welfare and welfare reform. Washington provides a generous safety net, exceeding national averages, while implementing several key features embodied in federal welfare reform (time limits and a work-first philosophy). Washington undertook some significant organizational changes to reach its present structure. Regarding child care, Washington is unique in giving local agencies flexibility in how they assign staff responsibilities within community service offices. Federal and state spending for child welfare have increased substantially. (Contains 17 endnotes.) (SM)

Published
2001

24. The Effective Methods for Providing Preconception Health Education

Author

Thompson, Terri Lynn

Abstract

Background: Infant mortality and maternal deaths are steadily increasing in the United States. Infant mortality and maternal deaths may be preventable if education is offered to the woman and her partner prior to conception. Preconception health education is not routinely addressed with a woman and her partner in routine visits to a health care provider. Reproductive health education is rarely discussed with a woman and her partner until after conception. In some cases, such education comes too late. Significance: Preconception health education can improve pregnancy-related health outcomes. Preconception health addresses lifespan health as a normal routine, including proper diet, exercise, and folic acid supplementation. Problem: Gaps exist in health professions education relating to preconception health. Healthcare providers are uncertain about how and when to address preconception health. Few disciplines include preconception health in their curricula. Aim: The aim of this DNP project was to introduce preconception health into the community via health professional education. Methods: An initial study was conducted to introduce to preconception health during one face-to-face session of a pre-licensure nursing course. Evaluation of the intervention compared the 12-item pretest and posttest results. This was a replication study from a previous improvement project implemented from accredited pre-licensure BSN program. Participants: The information was presented to the students in a live face-to-face presentation. In previous settings, the post-test scores consistently increased up to 50% compared to the pretest scores. In this study, data was collected from 71 first year nursing students during their first nursing theory course. Findings: The results of the information from the pretest and the posttest yielded up to a 50% increase in knowledge about preconception health were addressed in phase one of this study. With the improvement of pretest to posttest scores, it was determined that in-class presentation of preconception health education can improve knowledge and promote life style changes of health science students. Phase two of the study included peer-to-peer education based on a defined curriculum created from the Office of Minority Health. This was a pilot from a major university in the Inland Empire. Conclusion: The implementation of the project showed increased student enthusiasm about disseminating information about preconception health education and many colleges and universities have held trainings about peer-to-peer education on their campuses. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com/en-US/products/dissertations/individuals.shtml.]

Published
2017

30. Large-scale differentiation of iPSC-derived motor neurons from ALS and control subjects.

Author

Workman, Michael, Workman, Michael, Lim, Ryan, Wu, Jie, Frank, Aaron, Ornelas, Loren, Panther, Lindsay, Galvez, Erick, Perez, Daniel, Meepe, Imara, Lei, Susan, Valencia, Viviana, Gomez, Emilda, Liu, Chunyan, Moran, Ruby, Pinedo, Louis, Tsitkov, Stanislav, Ho, Ritchie, Kaye, Julia, Thompson, Terri, Rothstein, Jeffrey, Fraenkel, Ernest, Thompson, Leslie, Finkbeiner, Steven, Svendsen, Clive, Sareen, Dhruv, Workman, Michael, Workman, Michael, Lim, Ryan, Wu, Jie, Frank, Aaron, Ornelas, Loren, Panther, Lindsay, Galvez, Erick, Perez, Daniel, Meepe, Imara, Lei, Susan, Valencia, Viviana, Gomez, Emilda, Liu, Chunyan, Moran, Ruby, Pinedo, Louis, Tsitkov, Stanislav, Ho, Ritchie, Kaye, Julia, Thompson, Terri, Rothstein, Jeffrey, Fraenkel, Ernest, Thompson, Leslie, Finkbeiner, Steven, Svendsen, Clive, and Sareen, Dhruv

Abstract

Using induced pluripotent stem cells (iPSCs) to understand the mechanisms of neurological disease holds great promise; however, there is a lack of well-curated lines from a large array of participants. Answer ALS has generated over 1,000 iPSC lines from control and amyotrophic lateral sclerosis (ALS) patients along with clinical and whole-genome sequencing data. The current report summarizes cell marker and gene expression in motor neuron cultures derived from 92 healthy control and 341 ALS participants using a 32-day differentiation protocol. This is the largest set of iPSCs to be differentiated into motor neurons, and characterization suggests that cell composition and sex are significant sources of variability that need to be carefully controlled for in future studies. These data are reported as a resource for the scientific community that will utilize Answer ALS data for disease modeling using a wider array of omics being made available for these samples.

Published
2023

33. Leveraging the Tools Available: Using the Hyde Amendment to Preserve Minimum Abortion Access and Mitigate Harms in Restrictive States.

Author

Huberfeld, Nicole, McClain, Linda C., Ahmed, Aziza, Carrión, Fabiola, Hasselbacher, Lee, and Thompson, Terri-Ann

Subjects
ABORTION laws, MATERNAL health services, SOCIAL justice, REPRODUCTIVE rights, MEDICAID, INSURANCE
Abstract

The overturn of Roe v. Wade has resulted in fewer rights and resources for people seeking abortion care, particularly in the South. The Hyde Amendment has historically restricted abortion access for those enrolled in Medicaid. We argue here that its guarantees of minimum abortion coverage should be leveraged to offset harms where possible. [ABSTRACT FROM AUTHOR]

Published
2023
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38. Pedagogical Strategies for Teaching Literacy to ESL Immigrant Students: A Meta-Analysis

Author

Adesope, Olusola O., Lavin, Tracy, and Thompson, Terri

Abstract

Background: Many countries rely on immigrants for population growth and to maintain a skilled workforce. However, many such immigrants face literacy-related barriers to success in education and in the labour force. Aims: This meta-analysis reviews experimental and quasi-experimental studies to examine strategies for teaching English literacy to immigrant students. Method: Following an exhaustive and systematic search for studies meeting pre-determined inclusion criteria, two researchers independently extracted data from 26 English as a Second Language (ESL) studies involving 3,150 participants. These participants consisted of ESL immigrant students in kindergarten through grade 6 who were exposed to English literacy instructional interventions. Measured outcomes were reading and writing. Results and Conclusions: Mean effect sizes vary from small to large, depending on instructional interventions and outcome constructs. Across several different grade levels, settings, and methodological features, pedagogical strategies used in teaching ESL to immigrant students are associated with increased competence in reading and writing. Collaborative reading interventions, in which peers engage in oral interaction and cooperatively negotiate meaning and a shared understanding of texts, produced larger effects than systematic phonics instruction and multimedia-assisted reading interventions. The results show that the pedagogical strategies examined in this meta-analysis produced statistically significant benefits for students in all grade levels. The findings also show that students from low socio-economic status (SES) background benefit from ESL literacy interventions. However, significant heterogeneity was found in each subset. Educators and policy makers are encouraged to consider specific school contexts when making decisions about optimal pedagogical strategies. It is possible that contextual factors as well as ESL learner characteristics may influence the effectiveness of these strategies. To ensure literacy acquisition for immigrant students whose primary language is not English, it is important to continue to research successful literacy practices in ways that better inform educators and policy makers.

Published
2011
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41. A Systematic Review and Meta-Analysis of the Cognitive Correlates of Bilingualism

Author

Adesope, Olusola O., Lavin, Tracy, and Thompson, Terri

Abstract

A number of studies have documented the cognitive outcomes associated with bilingualism. To gain a clear understanding of the extent and diversity of these cognitive outcomes, the authors conducted a meta-analysis of studies that examined the cognitive correlates of bilingualism. Data from 63 studies (involving 6,022 participants) were extracted and analyzed following established protocols and procedures for conducting systematic reviews and guidelines for meta-analysis. Results indicate that bilingualism is reliably associated with several cognitive outcomes, including increased attentional control, working memory, metalinguistic awareness, and abstract and symbolic representation skills. Overall mean effect sizes varied from small to large, depending on the cognitive outcomes measured, and were moderated by methodological features of the studies. (Contains 7 tables and 2 notes.)

Published
2010
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44. “It just seemed like a perfect storm”: A multi-methods feasibility study on the use of Facebook, Google Ads, and Reddit to collect data on abortion-seeking experiences from people who considered but did not obtain abortion care in the United States

Author

Moseson, Heidi, primary, Seymour, Jane W., additional, Zuniga, Carmela, additional, Wollum, Alexandra, additional, Katz, Anna, additional, Thompson, Terri-Ann, additional, and Gerdts, Caitlin, additional

Published
2022
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45. sj-docx-1-whe-10.1177_17455057221124079 – Supplemental material for A qualitative analysis of Medicaid beneficiaries perceptions of prenatal and immediate postpartum contraception counseling

Author

Yates, Lindsey, Birken, Sarah, Thompson, Terri-Ann, Stuart, Gretchen S, Greene, Sandra, Hassmiller Lich, Kristen, and Weinberger, Morris

Subjects
FOS: Clinical medicine, 111402 Obstetrics and Gynaecology
Abstract

Supplemental material, sj-docx-1-whe-10.1177_17455057221124079 for A qualitative analysis of Medicaid beneficiaries perceptions of prenatal and immediate postpartum contraception counseling by Lindsey Yates, Sarah Birken, Terri-Ann Thompson, Gretchen S Stuart, Sandra Greene, Kristen Hassmiller Lich and Morris Weinberger in Women’s Health

Published
2022
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46. sj-docx-2-whe-10.1177_17455057221124079 – Supplemental material for A qualitative analysis of Medicaid beneficiaries perceptions of prenatal and immediate postpartum contraception counseling

Author

Yates, Lindsey, Birken, Sarah, Thompson, Terri-Ann, Stuart, Gretchen S, Greene, Sandra, Hassmiller Lich, Kristen, and Weinberger, Morris

Subjects
FOS: Clinical medicine, 111402 Obstetrics and Gynaecology
Abstract

Supplemental material, sj-docx-2-whe-10.1177_17455057221124079 for A qualitative analysis of Medicaid beneficiaries perceptions of prenatal and immediate postpartum contraception counseling by Lindsey Yates, Sarah Birken, Terri-Ann Thompson, Gretchen S Stuart, Sandra Greene, Kristen Hassmiller Lich and Morris Weinberger in Women’s Health

Published
2022
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50. Leveraging the Tools Available: Using the Hyde Amendment to Preserve Minimum Abortion Access and Mitigate Harms in Restrictive States.

Author

Carrión, Fabiola, Hasselbacher, Lee, and Thompson, Terri-Ann

Abstract

The overturn of Roe v. Wade has resulted in fewer rights and resources for people seeking abortion care, particularly in the South. The Hyde Amendment has historically restricted abortion access for those enrolled in Medicaid. We argue here that its guarantees of minimum abortion coverage should be leveraged to offset harms where possible. [ABSTRACT FROM AUTHOR]

Published
2023
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