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The article discusses the topic of being well and the challenge from the from the point of view of the Bible. The article also discusses the virtue of humanness from the testimony of the scriptures and the way showed by the Jesus Christ, including the understanding of the disciple Apostle of the Jesus Christ about the grace of the God.

Abstract: Validation is a familiar topic in computing, generally as a mechanism to protect a database from the effects of inappropriate data with the side effect of detecting some errors. As such, the validation rules are determined from the database schema using well understood methodologies. This paper takes a different view by examining digital validation as one of a set of processes that are designed to ensure that the incoming data (in this case, a plan of cadastral survey) is unambiguous and contains sufficient detail to define the legal spatial extents of a property. This is a complex question, especially since the rules and the decisions based on these processes must be defensible (therefore cannot contain arbitrary requirements imposed by a specific database model). Using the jurisdiction of Queensland, Australia, as a case study, this paper discusses the manual submission and lodgement of cadastral survey plans and the current 2D digital process as precursors to the automatic lodgement of all plans of survey. A set of validation rules is proposed for application to single geometric objects, to the relationship of objects on a single survey plan, and to objects that are independently defined on separate plans. It is asserted that, by the nature of the problem, this set is incomplete and will remain so. However, this research has identified a “checklist” of issues to be addressed by jurisdictions hoping to implement digital cadastral survey plan lodgement. The implications of this work in the context of the broader challenges in land administration and within the topic of 3D cadastral data are discussed. [Copyright &y& Elsevier]

The increasing complexity and flexibility of modern land use requires that cadastres need to manage information on the third and temporal (fourth) dimension. This article considers the registration of legal space of utility networks in cadastre in this 3D + time (=4D) context. A requirement analysis in three countries that have methods to register utility networks complying with their legal, organizational and technical structure (Turkey, the Netherlands and Queensland, Australia) is the basis for three alternatives for 4D cadastre to register utility networks. The three alternatives are analysed with respect to legal, organizational and technical cadastral requirements. This article presents a case study and a prototype from the Netherlands. In this country by law utilities are considered to be real estate objects with obligatory registration of ownership and geometry. This study shows that the 3D space and separate temporal attributes approach (state-based model) is a very promising solution to maintain temporal changes of utility networks and that this approach is to be preferred above the current practice, where the 3D and temporal aspects are not considered when registering a network. [ABSTRACT FROM AUTHOR]

Abstract: UCHL1/PGP 9.5 (also known as UCHL1 and PGP 9.5) was first detected as a “brain-specific protein” over 28 years ago. The protein is highly conserved and localized in neurones and neuroendocrine cells in vertebrates, forming an estimated 5–10% of cytoplasmic protein. A minor proportion in brain is tightly membrane-bound and the protein is also found in human oocytes and spermatogonia. A few specialised neurones lack UCHL1/PGP 9.5 and possibly replaceable neurones have low levels of the protein. UCHL1/PGP 9.5 shows sequence homology with UCHL3 (ubiquitin carboxyl-terminal hydrolase L3) and will similarly hydrolyse C-terminal adducts of ubiquitin. Both proteins show an unusual highly knotted structure with five “crossovers” but there are differences in substrate specificity, amino-acid sequence, and tissue distribution between them. There is no convincing evidence that UCHL1/PGP 9.5 can remove ubiquitin from proteins destined for proteasomal degradation, rather the substrate(s) of the enzyme appear to be one or more as yet unidentified short ubiquitin C-terminal extensions. Other suggested functions of the protein are plausible but largely unconfirmed. Isolated loss of UCHL1/PGP 9.5 function seen in the gracile axonal dystrophy (GAD) mouse due to a deletion in its gene results in a failure of axonal transport and a “dying-back” axonopathy beginning distally in long axons. The evidence that mutations in the UCHL1/PGP 9.5 gene lead to either significant susceptibility to or protection from Parkinson''s disease (or other human neurodegenerative disorders) is weak. Antibodies to the protein have found remarkably widespread application in the detection of fine nerves in peripheral tissues of many vertebrate species. [Copyright &y& Elsevier]

Point clouds contain high detail and high accuracy geometry representation of the scanned Earth surface parts. To manage the huge amount of data, the point clouds are traditionally organized on location and map-scale; e.g. in an octree structure, where top-levels of the tree contain few points suitable for small scale overviews and lower levels of the tree contain more points suitable for large scale detailed views. The drawback of this solution is that it is based on discrete levels, causing visual artifacts in the form of data density shocks when creating the commonly used perspective views. This paper presents a method based on an optimized distribution of points over continuous levels, avoiding the visualization shocks. The traditional distribution ratio's of data amounts over discrete levels of raster or vector data is considered the reference. How to convert this to point clouds with continuous levels (still benefiting from the proven advantages of the data distribution in discrete levels for efficient access at a wide range of scales)? In our solution, for each point a cLoD (continuous Level of Detail) value is computed and added as dimension to the point. A SFC (Space Filling Curve)-based nD data clustering technique can be used to organize the points, so that they can be efficiently queried. It should be noted that also other multi-dimensional indexing and clustering techniques could be applied to realize continuous levels based on the cLoD value. Besides the mathematical foundation of the approach also several implementations are described, varying from a 3D web-browser based solution to an augmented reality point cloud app in a mobile phone. The cLoD enables interactive real-time visualization using perspective views without data density shocks, while supporting continuous zoom-in/out and progressive data streaming between server and client. The described cLoD based approach is generic and supports different types of point clouds: from airborne, terrestrial, mobile and indoor laser scanning, but also from dense matching optical imagery or multi-beam echo soundings. [ABSTRACT FROM AUTHOR]

A method for determining a safety range for non-cancer risks is proposed, similar in concept to the range used for cancer in the management of waste sites. This safety range brings transparency to the chemical specific Reference Dose or Concentration by replacing their “order of magnitude” definitions with a scientifically-based range. EPA’s multiple RfCs for trichloroethylene (TCE) were evaluated as a case study. For TCE, a multi-endpoint safety range was judged to be 3 μg/m 3 to 30 μg/m, 3 based on a review of kidney effects found in NTP (1988), thymus effects found in Keil et al. (2009) and cardiac effects found in the Johnson et al. (2003) study. This multi-endpoint safety range is derived from studies for which the appropriate averaging time corresponds to different exposure durations, and, therefore, can be applied to both long- and short-term exposures with appropriate consideration of exposure averaging times. For shorter-term exposures, averaging time should be based on the time of cardiac development in humans during fetal growth, an average of approximately 20–25 days. [ABSTRACT FROM AUTHOR]