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4. Supplementary Figure 3 from ASTX660, a Novel Non-peptidomimetic Antagonist of cIAP1/2 and XIAP, Potently Induces TNFα-Dependent Apoptosis in Cancer Cell Lines and Inhibits Tumor Growth

Author

Ward, George A., primary, Lewis, Edward J., primary, Ahn, Jong Sook, primary, Johnson, Christopher N., primary, Lyons, John F., primary, Martins, Vanessa, primary, Munck, Joanne M., primary, Rich, Sharna J., primary, Smyth, Tomoko, primary, Thompson, Neil T., primary, Williams, Pamela A., primary, Wilsher, Nicola E., primary, Wallis, Nicola G., primary, and Chessari, Gianni, primary

Published
2023
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5. Supplementary Figure 2 from The HSP90 Inhibitor, AT13387, Is Effective against Imatinib-Sensitive and -Resistant Gastrointestinal Stromal Tumor Models

Author

Smyth, Tomoko, primary, Van Looy, Thomas, primary, Curry, Jayne E., primary, Rodriguez-Lopez, Ana M., primary, Wozniak, Agnieszka, primary, Zhu, Meijun, primary, Donsky, Rachel, primary, Morgan, Jennifer G., primary, Mayeda, Mark, primary, Fletcher, Jonathan A., primary, Schöffski, Patrick, primary, Lyons, John, primary, Thompson, Neil T., primary, and Wallis, Nicola G., primary

Published
2023
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6. Supplementary Tables 1-6 from ASTX029, a Novel Dual-mechanism ERK Inhibitor, Modulates Both the Phosphorylation and Catalytic Activity of ERK

Author

Munck, Joanne M., primary, Berdini, Valerio, primary, Bevan, Luke, primary, Brothwood, Jessica L., primary, Castro, Juan, primary, Courtin, Aurélie, primary, East, Charlotte, primary, Ferraldeschi, Roberta, primary, Heightman, Tom D., primary, Hindley, Christopher J., primary, Kucia-Tran, Justyna, primary, Lyons, John F., primary, Martins, Vanessa, primary, Muench, Sandra, primary, Murray, Christopher W., primary, Norton, David, primary, O'Reilly, Marc, primary, Reader, Michael, primary, Rees, David C., primary, Rich, Sharna J., primary, Richardson, Caroline J., primary, Shah, Alpesh D., primary, Stanczuk, Lukas, primary, Thompson, Neil T., primary, Wilsher, Nicola E., primary, Woolford, Alison J.-A., primary, and Wallis, Nicola G., primary

Published
2023
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7. Supplementary Figures 1-7 from ASTX029, a Novel Dual-mechanism ERK Inhibitor, Modulates Both the Phosphorylation and Catalytic Activity of ERK

Author

Munck, Joanne M., primary, Berdini, Valerio, primary, Bevan, Luke, primary, Brothwood, Jessica L., primary, Castro, Juan, primary, Courtin, Aurélie, primary, East, Charlotte, primary, Ferraldeschi, Roberta, primary, Heightman, Tom D., primary, Hindley, Christopher J., primary, Kucia-Tran, Justyna, primary, Lyons, John F., primary, Martins, Vanessa, primary, Muench, Sandra, primary, Murray, Christopher W., primary, Norton, David, primary, O'Reilly, Marc, primary, Reader, Michael, primary, Rees, David C., primary, Rich, Sharna J., primary, Richardson, Caroline J., primary, Shah, Alpesh D., primary, Stanczuk, Lukas, primary, Thompson, Neil T., primary, Wilsher, Nicola E., primary, Woolford, Alison J.-A., primary, and Wallis, Nicola G., primary

Published
2023
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8. Data from ASTX029, a Novel Dual-mechanism ERK Inhibitor, Modulates Both the Phosphorylation and Catalytic Activity of ERK

Author

Munck, Joanne M., primary, Berdini, Valerio, primary, Bevan, Luke, primary, Brothwood, Jessica L., primary, Castro, Juan, primary, Courtin, Aurélie, primary, East, Charlotte, primary, Ferraldeschi, Roberta, primary, Heightman, Tom D., primary, Hindley, Christopher J., primary, Kucia-Tran, Justyna, primary, Lyons, John F., primary, Martins, Vanessa, primary, Muench, Sandra, primary, Murray, Christopher W., primary, Norton, David, primary, O'Reilly, Marc, primary, Reader, Michael, primary, Rees, David C., primary, Rich, Sharna J., primary, Richardson, Caroline J., primary, Shah, Alpesh D., primary, Stanczuk, Lukas, primary, Thompson, Neil T., primary, Wilsher, Nicola E., primary, Woolford, Alison J.-A., primary, and Wallis, Nicola G., primary

Published
2023
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9. Supplementary Table 1 from ASTX660, a Novel Non-peptidomimetic Antagonist of cIAP1/2 and XIAP, Potently Induces TNFα-Dependent Apoptosis in Cancer Cell Lines and Inhibits Tumor Growth

Author

Ward, George A., primary, Lewis, Edward J., primary, Ahn, Jong Sook, primary, Johnson, Christopher N., primary, Lyons, John F., primary, Martins, Vanessa, primary, Munck, Joanne M., primary, Rich, Sharna J., primary, Smyth, Tomoko, primary, Thompson, Neil T., primary, Williams, Pamela A., primary, Wilsher, Nicola E., primary, Wallis, Nicola G., primary, and Chessari, Gianni, primary

Published
2023
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10. Data from Potent, Selective Inhibitors of Fibroblast Growth Factor Receptor Define Fibroblast Growth Factor Dependence in Preclinical Cancer Models

Author

Squires, Matthew, primary, Ward, George, primary, Saxty, Gordan, primary, Berdini, Valerio, primary, Cleasby, Anne, primary, King, Peter, primary, Angibaud, Patrick, primary, Perera, Tim, primary, Fazal, Lynsey, primary, Ross, Douglas, primary, Jones, Charlotte Griffiths, primary, Madin, Andrew, primary, Benning, Rajdeep K., primary, Vickerstaffe, Emma, primary, O'Brien, Alistair, primary, Frederickson, Martyn, primary, Reader, Michael, primary, Hamlett, Christopher, primary, Batey, Michael A., primary, Rich, Sharna, primary, Carr, Maria, primary, Miller, Darcey, primary, Feltell, Ruth, primary, Thiru, Abarna, primary, Bethell, Susanne, primary, Devine, Lindsay A., primary, Graham, Brent L., primary, Pike, Andrew, primary, Cosme, Jose, primary, Lewis, Edward J., primary, Freyne, Eddy, primary, Lyons, John, primary, Irving, Julie, primary, Murray, Christopher, primary, Newell, David R., primary, and Thompson, Neil T., primary

Published
2023
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11. Supplementary Figure 4 from ASTX660, a Novel Non-peptidomimetic Antagonist of cIAP1/2 and XIAP, Potently Induces TNFα-Dependent Apoptosis in Cancer Cell Lines and Inhibits Tumor Growth

Author

Ward, George A., primary, Lewis, Edward J., primary, Ahn, Jong Sook, primary, Johnson, Christopher N., primary, Lyons, John F., primary, Martins, Vanessa, primary, Munck, Joanne M., primary, Rich, Sharna J., primary, Smyth, Tomoko, primary, Thompson, Neil T., primary, Williams, Pamela A., primary, Wilsher, Nicola E., primary, Wallis, Nicola G., primary, and Chessari, Gianni, primary

Published
2023
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12. Supplementary Figure 1 from The HSP90 Inhibitor, AT13387, Is Effective against Imatinib-Sensitive and -Resistant Gastrointestinal Stromal Tumor Models

Author

Smyth, Tomoko, primary, Van Looy, Thomas, primary, Curry, Jayne E., primary, Rodriguez-Lopez, Ana M., primary, Wozniak, Agnieszka, primary, Zhu, Meijun, primary, Donsky, Rachel, primary, Morgan, Jennifer G., primary, Mayeda, Mark, primary, Fletcher, Jonathan A., primary, Schöffski, Patrick, primary, Lyons, John, primary, Thompson, Neil T., primary, and Wallis, Nicola G., primary

Published
2023
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13. Supplementary Methods from ASTX029, a Novel Dual-mechanism ERK Inhibitor, Modulates Both the Phosphorylation and Catalytic Activity of ERK

Author

Munck, Joanne M., primary, Berdini, Valerio, primary, Bevan, Luke, primary, Brothwood, Jessica L., primary, Castro, Juan, primary, Courtin, Aurélie, primary, East, Charlotte, primary, Ferraldeschi, Roberta, primary, Heightman, Tom D., primary, Hindley, Christopher J., primary, Kucia-Tran, Justyna, primary, Lyons, John F., primary, Martins, Vanessa, primary, Muench, Sandra, primary, Murray, Christopher W., primary, Norton, David, primary, O'Reilly, Marc, primary, Reader, Michael, primary, Rees, David C., primary, Rich, Sharna J., primary, Richardson, Caroline J., primary, Shah, Alpesh D., primary, Stanczuk, Lukas, primary, Thompson, Neil T., primary, Wilsher, Nicola E., primary, Woolford, Alison J.-A., primary, and Wallis, Nicola G., primary

Published
2023
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14. Supplementary Figures 1-4 from Preclinical Pharmacology, Antitumor Activity, and Development of Pharmacodynamic Markers for the Novel, Potent AKT Inhibitor CCT128930

Author

Yap, Timothy A., primary, Walton, Mike I., primary, Hunter, Lisa-Jane K., primary, Valenti, Melanie, primary, de Haven Brandon, Alexis, primary, Eve, Paul D., primary, Ruddle, Ruth, primary, Heaton, Simon P., primary, Henley, Alan, primary, Pickard, Lisa, primary, Vijayaraghavan, Gowri, primary, Caldwell, John J., primary, Thompson, Neil T., primary, Aherne, Wynne, primary, Raynaud, Florence I., primary, Eccles, Suzanne A., primary, Workman, Paul, primary, Collins, Ian, primary, and Garrett, Michelle D., primary

Published
2023
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15. Supplemental Figure 1 from Discovery and Pharmacological Characterization of JNJ-42756493 (Erdafitinib), a Functionally Selective Small-Molecule FGFR Family Inhibitor

Author

Perera, Timothy P.S., primary, Jovcheva, Eleonora, primary, Mevellec, Laurence, primary, Vialard, Jorge, primary, De Lange, Desiree, primary, Verhulst, Tinne, primary, Paulussen, Caroline, primary, Van De Ven, Kelly, primary, King, Peter, primary, Freyne, Eddy, primary, Rees, David C., primary, Squires, Matthew, primary, Saxty, Gordon, primary, Page, Martin, primary, Murray, Christopher W., primary, Gilissen, Ron, primary, Ward, George, primary, Thompson, Neil T., primary, Newell, David R., primary, Cheng, Na, primary, Xie, Liang, primary, Yang, Jennifer, primary, Platero, Suso J., primary, Karkera, Jayaprakash D., primary, Moy, Christopher, primary, Angibaud, Patrick, primary, Laquerre, Sylvie, primary, and Lorenzi, Matthew V., primary

Published
2023
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16. Data from ASTX660, a Novel Non-peptidomimetic Antagonist of cIAP1/2 and XIAP, Potently Induces TNFα-Dependent Apoptosis in Cancer Cell Lines and Inhibits Tumor Growth

Author

Ward, George A., primary, Lewis, Edward J., primary, Ahn, Jong Sook, primary, Johnson, Christopher N., primary, Lyons, John F., primary, Martins, Vanessa, primary, Munck, Joanne M., primary, Rich, Sharna J., primary, Smyth, Tomoko, primary, Thompson, Neil T., primary, Williams, Pamela A., primary, Wilsher, Nicola E., primary, Wallis, Nicola G., primary, and Chessari, Gianni, primary

Published
2023
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17. Supplementary Figure Legend from The HSP90 Inhibitor, AT13387, Is Effective against Imatinib-Sensitive and -Resistant Gastrointestinal Stromal Tumor Models

Author

Smyth, Tomoko, primary, Van Looy, Thomas, primary, Curry, Jayne E., primary, Rodriguez-Lopez, Ana M., primary, Wozniak, Agnieszka, primary, Zhu, Meijun, primary, Donsky, Rachel, primary, Morgan, Jennifer G., primary, Mayeda, Mark, primary, Fletcher, Jonathan A., primary, Schöffski, Patrick, primary, Lyons, John, primary, Thompson, Neil T., primary, and Wallis, Nicola G., primary

Published
2023
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18. Supplementary Materials and Methods from ASTX660, a Novel Non-peptidomimetic Antagonist of cIAP1/2 and XIAP, Potently Induces TNFα-Dependent Apoptosis in Cancer Cell Lines and Inhibits Tumor Growth

Author

Ward, George A., primary, Lewis, Edward J., primary, Ahn, Jong Sook, primary, Johnson, Christopher N., primary, Lyons, John F., primary, Martins, Vanessa, primary, Munck, Joanne M., primary, Rich, Sharna J., primary, Smyth, Tomoko, primary, Thompson, Neil T., primary, Williams, Pamela A., primary, Wilsher, Nicola E., primary, Wallis, Nicola G., primary, and Chessari, Gianni, primary

Published
2023
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19. Supplemental Table 4 from Discovery and Pharmacological Characterization of JNJ-42756493 (Erdafitinib), a Functionally Selective Small-Molecule FGFR Family Inhibitor

Author

Perera, Timothy P.S., primary, Jovcheva, Eleonora, primary, Mevellec, Laurence, primary, Vialard, Jorge, primary, De Lange, Desiree, primary, Verhulst, Tinne, primary, Paulussen, Caroline, primary, Van De Ven, Kelly, primary, King, Peter, primary, Freyne, Eddy, primary, Rees, David C., primary, Squires, Matthew, primary, Saxty, Gordon, primary, Page, Martin, primary, Murray, Christopher W., primary, Gilissen, Ron, primary, Ward, George, primary, Thompson, Neil T., primary, Newell, David R., primary, Cheng, Na, primary, Xie, Liang, primary, Yang, Jennifer, primary, Platero, Suso J., primary, Karkera, Jayaprakash D., primary, Moy, Christopher, primary, Angibaud, Patrick, primary, Laquerre, Sylvie, primary, and Lorenzi, Matthew V., primary

Published
2023
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20. Supplementary Figure 1 from ASTX660, a Novel Non-peptidomimetic Antagonist of cIAP1/2 and XIAP, Potently Induces TNFα-Dependent Apoptosis in Cancer Cell Lines and Inhibits Tumor Growth

Author

Ward, George A., primary, Lewis, Edward J., primary, Ahn, Jong Sook, primary, Johnson, Christopher N., primary, Lyons, John F., primary, Martins, Vanessa, primary, Munck, Joanne M., primary, Rich, Sharna J., primary, Smyth, Tomoko, primary, Thompson, Neil T., primary, Williams, Pamela A., primary, Wilsher, Nicola E., primary, Wallis, Nicola G., primary, and Chessari, Gianni, primary

Published
2023
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21. Supplementary Table 2 from ASTX660, a Novel Non-peptidomimetic Antagonist of cIAP1/2 and XIAP, Potently Induces TNFα-Dependent Apoptosis in Cancer Cell Lines and Inhibits Tumor Growth

Author

Ward, George A., primary, Lewis, Edward J., primary, Ahn, Jong Sook, primary, Johnson, Christopher N., primary, Lyons, John F., primary, Martins, Vanessa, primary, Munck, Joanne M., primary, Rich, Sharna J., primary, Smyth, Tomoko, primary, Thompson, Neil T., primary, Williams, Pamela A., primary, Wilsher, Nicola E., primary, Wallis, Nicola G., primary, and Chessari, Gianni, primary

Published
2023
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22. Data from Discovery and Pharmacological Characterization of JNJ-42756493 (Erdafitinib), a Functionally Selective Small-Molecule FGFR Family Inhibitor

Author

Perera, Timothy P.S., primary, Jovcheva, Eleonora, primary, Mevellec, Laurence, primary, Vialard, Jorge, primary, De Lange, Desiree, primary, Verhulst, Tinne, primary, Paulussen, Caroline, primary, Van De Ven, Kelly, primary, King, Peter, primary, Freyne, Eddy, primary, Rees, David C., primary, Squires, Matthew, primary, Saxty, Gordon, primary, Page, Martin, primary, Murray, Christopher W., primary, Gilissen, Ron, primary, Ward, George, primary, Thompson, Neil T., primary, Newell, David R., primary, Cheng, Na, primary, Xie, Liang, primary, Yang, Jennifer, primary, Platero, Suso J., primary, Karkera, Jayaprakash D., primary, Moy, Christopher, primary, Angibaud, Patrick, primary, Laquerre, Sylvie, primary, and Lorenzi, Matthew V., primary

Published
2023
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23. Supplemental Table 2 from Discovery and Pharmacological Characterization of JNJ-42756493 (Erdafitinib), a Functionally Selective Small-Molecule FGFR Family Inhibitor

Author

Perera, Timothy P.S., primary, Jovcheva, Eleonora, primary, Mevellec, Laurence, primary, Vialard, Jorge, primary, De Lange, Desiree, primary, Verhulst, Tinne, primary, Paulussen, Caroline, primary, Van De Ven, Kelly, primary, King, Peter, primary, Freyne, Eddy, primary, Rees, David C., primary, Squires, Matthew, primary, Saxty, Gordon, primary, Page, Martin, primary, Murray, Christopher W., primary, Gilissen, Ron, primary, Ward, George, primary, Thompson, Neil T., primary, Newell, David R., primary, Cheng, Na, primary, Xie, Liang, primary, Yang, Jennifer, primary, Platero, Suso J., primary, Karkera, Jayaprakash D., primary, Moy, Christopher, primary, Angibaud, Patrick, primary, Laquerre, Sylvie, primary, and Lorenzi, Matthew V., primary

Published
2023
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24. Supplementary Methods, Figures 1-4, Tables 1-2 from Potent, Selective Inhibitors of Fibroblast Growth Factor Receptor Define Fibroblast Growth Factor Dependence in Preclinical Cancer Models

Author

Squires, Matthew, primary, Ward, George, primary, Saxty, Gordan, primary, Berdini, Valerio, primary, Cleasby, Anne, primary, King, Peter, primary, Angibaud, Patrick, primary, Perera, Tim, primary, Fazal, Lynsey, primary, Ross, Douglas, primary, Jones, Charlotte Griffiths, primary, Madin, Andrew, primary, Benning, Rajdeep K., primary, Vickerstaffe, Emma, primary, O'Brien, Alistair, primary, Frederickson, Martyn, primary, Reader, Michael, primary, Hamlett, Christopher, primary, Batey, Michael A., primary, Rich, Sharna, primary, Carr, Maria, primary, Miller, Darcey, primary, Feltell, Ruth, primary, Thiru, Abarna, primary, Bethell, Susanne, primary, Devine, Lindsay A., primary, Graham, Brent L., primary, Pike, Andrew, primary, Cosme, Jose, primary, Lewis, Edward J., primary, Freyne, Eddy, primary, Lyons, John, primary, Irving, Julie, primary, Murray, Christopher, primary, Newell, David R., primary, and Thompson, Neil T., primary

Published
2023
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25. Supplemental Table 1 from Discovery and Pharmacological Characterization of JNJ-42756493 (Erdafitinib), a Functionally Selective Small-Molecule FGFR Family Inhibitor

Author

Perera, Timothy P.S., primary, Jovcheva, Eleonora, primary, Mevellec, Laurence, primary, Vialard, Jorge, primary, De Lange, Desiree, primary, Verhulst, Tinne, primary, Paulussen, Caroline, primary, Van De Ven, Kelly, primary, King, Peter, primary, Freyne, Eddy, primary, Rees, David C., primary, Squires, Matthew, primary, Saxty, Gordon, primary, Page, Martin, primary, Murray, Christopher W., primary, Gilissen, Ron, primary, Ward, George, primary, Thompson, Neil T., primary, Newell, David R., primary, Cheng, Na, primary, Xie, Liang, primary, Yang, Jennifer, primary, Platero, Suso J., primary, Karkera, Jayaprakash D., primary, Moy, Christopher, primary, Angibaud, Patrick, primary, Laquerre, Sylvie, primary, and Lorenzi, Matthew V., primary

Published
2023
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26. Supplemental Table 3 from Discovery and Pharmacological Characterization of JNJ-42756493 (Erdafitinib), a Functionally Selective Small-Molecule FGFR Family Inhibitor

Author

Perera, Timothy P.S., primary, Jovcheva, Eleonora, primary, Mevellec, Laurence, primary, Vialard, Jorge, primary, De Lange, Desiree, primary, Verhulst, Tinne, primary, Paulussen, Caroline, primary, Van De Ven, Kelly, primary, King, Peter, primary, Freyne, Eddy, primary, Rees, David C., primary, Squires, Matthew, primary, Saxty, Gordon, primary, Page, Martin, primary, Murray, Christopher W., primary, Gilissen, Ron, primary, Ward, George, primary, Thompson, Neil T., primary, Newell, David R., primary, Cheng, Na, primary, Xie, Liang, primary, Yang, Jennifer, primary, Platero, Suso J., primary, Karkera, Jayaprakash D., primary, Moy, Christopher, primary, Angibaud, Patrick, primary, Laquerre, Sylvie, primary, and Lorenzi, Matthew V., primary

Published
2023
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27. Supplementary Figure 2 from ASTX660, a Novel Non-peptidomimetic Antagonist of cIAP1/2 and XIAP, Potently Induces TNFα-Dependent Apoptosis in Cancer Cell Lines and Inhibits Tumor Growth

Author

Ward, George A., primary, Lewis, Edward J., primary, Ahn, Jong Sook, primary, Johnson, Christopher N., primary, Lyons, John F., primary, Martins, Vanessa, primary, Munck, Joanne M., primary, Rich, Sharna J., primary, Smyth, Tomoko, primary, Thompson, Neil T., primary, Williams, Pamela A., primary, Wilsher, Nicola E., primary, Wallis, Nicola G., primary, and Chessari, Gianni, primary

Published
2023
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28. Supplementary Table 5A from AT13148 Is a Novel, Oral Multi-AGC Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity

Author

Yap, Timothy A., primary, Walton, Mike I., primary, Grimshaw, Kyla M., primary, te Poele, Robert H., primary, Eve, Paul D., primary, Valenti, Melanie R., primary, de Haven Brandon, Alexis K., primary, Martins, Vanessa, primary, Zetterlund, Anna, primary, Heaton, Simon P., primary, Heinzmann, Kathrin, primary, Jones, Paul S., primary, Feltell, Ruth E., primary, Reule, Matthias, primary, Woodhead, Steven J., primary, Davies, Thomas G., primary, Lyons, John F., primary, Raynaud, Florence I., primary, Eccles, Suzanne A., primary, Workman, Paul, primary, Thompson, Neil T., primary, and Garrett, Michelle D., primary

Published
2023
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29. Supplementary Table 6A from AT13148 Is a Novel, Oral Multi-AGC Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity

Author

Yap, Timothy A., primary, Walton, Mike I., primary, Grimshaw, Kyla M., primary, te Poele, Robert H., primary, Eve, Paul D., primary, Valenti, Melanie R., primary, de Haven Brandon, Alexis K., primary, Martins, Vanessa, primary, Zetterlund, Anna, primary, Heaton, Simon P., primary, Heinzmann, Kathrin, primary, Jones, Paul S., primary, Feltell, Ruth E., primary, Reule, Matthias, primary, Woodhead, Steven J., primary, Davies, Thomas G., primary, Lyons, John F., primary, Raynaud, Florence I., primary, Eccles, Suzanne A., primary, Workman, Paul, primary, Thompson, Neil T., primary, and Garrett, Michelle D., primary

Published
2023
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33. Supplementary Figures 1-7, Tables 1-4 from AT13148 Is a Novel, Oral Multi-AGC Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity

Author

Yap, Timothy A., primary, Walton, Mike I., primary, Grimshaw, Kyla M., primary, te Poele, Robert H., primary, Eve, Paul D., primary, Valenti, Melanie R., primary, de Haven Brandon, Alexis K., primary, Martins, Vanessa, primary, Zetterlund, Anna, primary, Heaton, Simon P., primary, Heinzmann, Kathrin, primary, Jones, Paul S., primary, Feltell, Ruth E., primary, Reule, Matthias, primary, Woodhead, Steven J., primary, Davies, Thomas G., primary, Lyons, John F., primary, Raynaud, Florence I., primary, Eccles, Suzanne A., primary, Workman, Paul, primary, Thompson, Neil T., primary, and Garrett, Michelle D., primary

Published
2023
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34. Supplementary Methods, Figure Legends 1-7 from AT13148 Is a Novel, Oral Multi-AGC Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity

Author

Yap, Timothy A., primary, Walton, Mike I., primary, Grimshaw, Kyla M., primary, te Poele, Robert H., primary, Eve, Paul D., primary, Valenti, Melanie R., primary, de Haven Brandon, Alexis K., primary, Martins, Vanessa, primary, Zetterlund, Anna, primary, Heaton, Simon P., primary, Heinzmann, Kathrin, primary, Jones, Paul S., primary, Feltell, Ruth E., primary, Reule, Matthias, primary, Woodhead, Steven J., primary, Davies, Thomas G., primary, Lyons, John F., primary, Raynaud, Florence I., primary, Eccles, Suzanne A., primary, Workman, Paul, primary, Thompson, Neil T., primary, and Garrett, Michelle D., primary

Published
2023
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36. ASTX029, a Novel Dual-mechanism ERK Inhibitor, Modulates Both the Phosphorylation and Catalytic Activity of ERK

Author

Munck, Joanne M., primary, Berdini, Valerio, additional, Bevan, Luke, additional, Brothwood, Jessica L., additional, Castro, Juan, additional, Courtin, Aurélie, additional, East, Charlotte, additional, Ferraldeschi, Roberta, additional, Heightman, Tom D., additional, Hindley, Christopher J., additional, Kucia-Tran, Justyna, additional, Lyons, John F., additional, Martins, Vanessa, additional, Muench, Sandra, additional, Murray, Christopher W., additional, Norton, David, additional, O'Reilly, Marc, additional, Reader, Michael, additional, Rees, David C., additional, Rich, Sharna J., additional, Richardson, Caroline J., additional, Shah, Alpesh D., additional, Stanczuk, Lukas, additional, Thompson, Neil T., additional, Wilsher, Nicola E., additional, Woolford, Alison J.-A., additional, and Wallis, Nicola G., additional

Published
2021
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37. Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein–Protein Interaction

Author

Chessari, Gianni, primary, Hardcastle, Ian R., additional, Ahn, Jong Sook, additional, Anil, Burcu, additional, Anscombe, Elizabeth, additional, Bawn, Ruth H., additional, Bevan, Luke D., additional, Blackburn, Timothy J., additional, Buck, Ildiko, additional, Cano, Celine, additional, Carbain, Benoit, additional, Castro, Juan, additional, Cons, Ben, additional, Cully, Sarah J., additional, Endicott, Jane A., additional, Fazal, Lynsey, additional, Golding, Bernard T., additional, Griffin, Roger J., additional, Haggerty, Karen, additional, Harnor, Suzannah J., additional, Hearn, Keisha, additional, Hobson, Stephen, additional, Holvey, Rhian S., additional, Howard, Steven, additional, Jennings, Claire E., additional, Johnson, Christopher N., additional, Lunec, John, additional, Miller, Duncan C., additional, Newell, David R., additional, Noble, Martin E. M., additional, Reeks, Judith, additional, Revill, Charlotte H., additional, Riedinger, Christiane, additional, St. Denis, Jeffrey D., additional, Tamanini, Emiliano, additional, Thomas, Huw, additional, Thompson, Neil T., additional, Vinković, Mladen, additional, Wedge, Stephen R., additional, Williams, Pamela A., additional, Wilsher, Nicola E., additional, Zhang, Bian, additional, and Zhao, Yan, additional

Published
2021
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41. A Fragment-Derived Clinical Candidate for Antagonism of X-Linked and Cellular Inhibitor of Apoptosis Proteins: 1-(6-[(4-Fluorophenyl)methyl]-5-(hydroxymethyl)-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-b]pyridin-1-yl)-2-[(2R,5R)-5-methyl-2-([(3R)-3-methylmorpholin-4-yl]methyl)piperazin-1-yl]ethan-1-one (ASTX660)

Author

Johnson, Christopher N., primary, Ahn, Jong Sook, additional, Buck, Ildiko M., additional, Chiarparin, Elisabetta, additional, Day, James E. H., additional, Hopkins, Anna, additional, Howard, Steven, additional, Lewis, Edward J., additional, Martins, Vanessa, additional, Millemaggi, Alessia, additional, Munck, Joanne M., additional, Page, Lee W., additional, Peakman, Torren, additional, Reader, Michael, additional, Rich, Sharna J., additional, Saxty, Gordon, additional, Smyth, Tomoko, additional, Thompson, Neil T., additional, Ward, George A., additional, Williams, Pamela A., additional, Wilsher, Nicola E., additional, and Chessari, Gianni, additional

Published
2018
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42. ASTX660, a Novel Non-peptidomimetic Antagonist of cIAP1/2 and XIAP, Potently Induces TNFα-Dependent Apoptosis in Cancer Cell Lines and Inhibits Tumor Growth

Author

Ward, George A., primary, Lewis, Edward J., additional, Ahn, Jong Sook, additional, Johnson, Christopher N., additional, Lyons, John F., additional, Martins, Vanessa, additional, Munck, Joanne M., additional, Rich, Sharna J., additional, Smyth, Tomoko, additional, Thompson, Neil T., additional, Williams, Pamela A., additional, Wilsher, Nicola E., additional, Wallis, Nicola G., additional, and Chessari, Gianni, additional

Published
2018
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43. Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2

Author

Heightman, Tom D., primary, Berdini, Valerio, additional, Braithwaite, Hannah, additional, Buck, Ildiko M., additional, Cassidy, Megan, additional, Castro, Juan, additional, Courtin, Aurélie, additional, Day, James E. H., additional, East, Charlotte, additional, Fazal, Lynsey, additional, Graham, Brent, additional, Griffiths-Jones, Charlotte M., additional, Lyons, John F., additional, Martins, Vanessa, additional, Muench, Sandra, additional, Munck, Joanne M., additional, Norton, David, additional, O’Reilly, Marc, additional, Palmer, Nick, additional, Pathuri, Puja, additional, Reader, Michael, additional, Rees, David C., additional, Rich, Sharna J., additional, Richardson, Caroline, additional, Saini, Harpreet, additional, Thompson, Neil T., additional, Wallis, Nicola G., additional, Walton, Hugh, additional, Wilsher, Nicola E., additional, Woolford, Alison J.-A., additional, Cooke, Michael, additional, Cousin, David, additional, Onions, Stuart, additional, Shannon, Jonathan, additional, Watts, John, additional, and Murray, Christopher W., additional

Published
2018
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44. Abstract B154: Characterization of a novel ERK1/2 inhibitor, which modulates the phosphorylation and catalytic activity of ERK1/2

Author

Munck, Joanne M., primary, Berdini, Valerio, additional, Bevan, Luke D., additional, Braithwaite, Hannah, additional, Buck, Ildiko M., additional, Cassidy, Megan, additional, Castro, Juan, additional, Courtin, Aurelie, additional, Day, James E., additional, East, Charlotte, additional, Fazal, Lynsey, additional, Graham, Brent, additional, Griffiths-Jones, Charlotte M., additional, Heightman, Tom D., additional, Hindley, Chris J., additional, Kidane, Birikiti, additional, Kucia-Tran, Justyna, additional, Lyons, John F., additional, Martins, Vanessa, additional, Muench, Sandra, additional, Murray, Chris W., additional, Norton, David, additional, O'Reilly, Marc, additional, Palmer, Nick, additional, Pathuri, Puja, additional, Reader, Mike, additional, Rees, David C., additional, Rich, Sharna J., additional, Richardson, Caroline J., additional, Saini, Harpreet K., additional, Shah, Alpesh, additional, Stanczuk, Lukas, additional, Thompson, Neil T., additional, Walton, Hugh, additional, Wilsher, Nicola E., additional, Woolford, Alison J., additional, and Wallis, Nicola G., additional

Published
2018
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45. Discovery and Pharmacological Characterization of JNJ-42756493 (Erdafitinib), a Functionally Selective Small-Molecule FGFR Family Inhibitor

Author

Perera, Timothy P.S., primary, Jovcheva, Eleonora, additional, Mevellec, Laurence, additional, Vialard, Jorge, additional, De Lange, Desiree, additional, Verhulst, Tinne, additional, Paulussen, Caroline, additional, Van De Ven, Kelly, additional, King, Peter, additional, Freyne, Eddy, additional, Rees, David C., additional, Squires, Matthew, additional, Saxty, Gordon, additional, Page, Martin, additional, Murray, Christopher W., additional, Gilissen, Ron, additional, Ward, George, additional, Thompson, Neil T., additional, Newell, David R., additional, Cheng, Na, additional, Xie, Liang, additional, Yang, Jennifer, additional, Platero, Suso J., additional, Karkera, Jayaprakash D., additional, Moy, Christopher, additional, Angibaud, Patrick, additional, Laquerre, Sylvie, additional, and Lorenzi, Matthew V., additional

Published
2017
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47. Abstract 1247: ERK1/2 inhibitors with distinct modes of inhibition confer different response profiles in KRAS mutant cancers

Author

Munck, Joanne M., primary, Graham, Brent, additional, Castro, Juan, additional, Courtin, Aurelie, additional, Muench, Sandra, additional, Rich, Sharna, additional, Saini, Harpreet K., additional, Brothwood, Jessica, additional, Lyons, John, additional, Thompson, Neil T., additional, Wallis, Nicola G., additional, and Murray, Chris, additional

Published
2016
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48. Inhibition of HSP90 by AT13387 Delays the Emergence of Resistance to BRAF Inhibitors and Overcomes Resistance to Dual BRAF and MEK Inhibition in Melanoma Models

Author

Smyth, Tomoko, primary, Paraiso, Kim H.T., additional, Hearn, Keisha, additional, Rodriguez-Lopez, Ana M., additional, Munck, Joanne M., additional, Haarberg, H. Eirik, additional, Sondak, Vernon K., additional, Thompson, Neil T., additional, Azab, Mohammad, additional, Lyons, John F., additional, Smalley, Keiran S.M., additional, and Wallis, Nicola G., additional

Published
2014
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50. The HSP90 Inhibitor, AT13387, Is Effective against Imatinib-Sensitive and -Resistant Gastrointestinal Stromal Tumor Models

Author

Smyth, Tomoko, primary, Van Looy, Thomas, additional, Curry, Jayne E., additional, Rodriguez-Lopez, Ana M., additional, Wozniak, Agnieszka, additional, Zhu, Meijun, additional, Donsky, Rachel, additional, Morgan, Jennifer G., additional, Mayeda, Mark, additional, Fletcher, Jonathan A., additional, Schöffski, Patrick, additional, Lyons, John, additional, Thompson, Neil T., additional, and Wallis, Nicola G., additional

Published
2012
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