Search

Your search keyword '"Thompson, Elizabeth D."' showing total 484 results
Start Over Author "Thompson, Elizabeth D."
484 results on '"Thompson, Elizabeth D."'

1. Neoplastic Progression in Macroscopic Precursor Lesions of the Pancreas

Author

Thompson, Elizabeth D.

Subjects
Care and treatment, Evaluation, Development and progression, Prognosis -- Evaluation, Pancreatic cancer -- Development and progression -- Care and treatment, Cancer research, Oncology, Experimental, Cancer -- Research
Abstract

Understanding of the biology, pathology, and natural history of cystic lesions of the pancreas has expanded dramatically. As recently as the 1970s, all tumors of the pancreas with cystic morphology [...], * Context.--Macroscopic precursor lesions of the pancreas represent a complex clinical management problem. Molecular characterization of pancreatic cysts has helped to confirm and refine clinical and pathologic classifications of these lesions, inform our understanding of tumorigenesis in the pancreas, and provide opportunities for preoperative diagnosis. Objective.--To review the pathologic classification of macroscopic cystic lesions of the pancreas: intraductal papillary mucinous neoplasms (IPMNs), mucinous cystic neoplasms (MCNs), intraductal oncocytic papillary neoplasms (IOPNs), and intraductal tubulopapillary neoplasms (ITPNs), and to describe our current state of understanding of their molecular underpinnings, relationship to invasive carcinomas, and implications for diagnosis and prognostication. Data Sources.--We assessed the current primary literature and current World Health Organization Classification of Digestive System Tumours. Conclusions.--Macroscopic cystic lesions of the pancreas are morphologically and molecularly diverse. IPMNs and MCNs share mucinous cytoplasm with papillae. MCNs are defined by ovarian-type stroma. IOPNs have granular eosinophilic cytoplasm, prominent nucleoli, and complex, arborizing papillae. ITPNs demonstrate complex, back-to-back tubules and anastomosing papillae and lack prominent intracellular mucin. IPMNs and MCNs are characterized by driver mutations in KRAS/ GNAS (IPMNs) and KRAS (MCNs), with later driver events in RNF43, CDKN2A, SMAD4, and TP53. In contrast, IOPNs and ITPNs have recurrent rearrangements in PRKACA/PRKACB and MAPK-associated genes, respectively. The recurrent alterations described in cysts provide an opportunity for diagnosis using aspirated cyst fluid. Molecular characterization of IPMNs shows a striking spatial and mutational heterogeneity, challenging traditional models of neoplastic development and creating challenges to interpretation of cyst fluid sequencing results. (Arch Pathol Lab Med. 2024;148:980-988; doi: 10.5858/arpa.2023-0358-RA)

Published
2024
Full Text
View/download PDF

2. 3D genomic mapping reveals multifocality of human pancreatic precancers

Author

Braxton, Alicia M., Kiemen, Ashley L., Grahn, Mia P., Forjaz, André, Parksong, Jeeun, Mahesh Babu, Jaanvi, Lai, Jiaying, Zheng, Lily, Niknafs, Noushin, Jiang, Liping, Cheng, Haixia, Song, Qianqian, Reichel, Rebecca, Graham, Sarah, Damanakis, Alexander I., Fischer, Catherine G., Mou, Stephanie, Metz, Cameron, Granger, Julie, Liu, Xiao-Ding, Bachmann, Niklas, Zhu, Yutong, Liu, YunZhou, Almagro-Pérez, Cristina, Jiang, Ann Chenyu, Yoo, Jeonghyun, Kim, Bridgette, Du, Scott, Foster, Eli, Hsu, Jocelyn Y., Rivera, Paula Andreu, Chu, Linda C., Liu, Fengze, Fishman, Elliot K., Yuille, Alan, Roberts, Nicholas J., Thompson, Elizabeth D., Scharpf, Robert B., Cornish, Toby C., Jiao, Yuchen, Karchin, Rachel, Hruban, Ralph H., Wu, Pei-Hsun, Wirtz, Denis, and Wood, Laura D.

Published
2024
Full Text
View/download PDF

3. Concordance of Whole-Slide Imaging and Conventional Light Microscopy for Assessment of Pathologic Response Following Neoadjuvant Therapy for Lung Cancer

Author

Deutsch, Julie S., Wang, Daphne, Chen, Krista Y., Cimino-Mathews, Ashley, Thompson, Elizabeth D., Jedrych, Jaroslaw, Anders, Robert A., Gabrielson, Edward, Illei, Peter B., Uttam, Sonali, Fiorante, Alexa, Cohen, Emily, Fotheringham, Michael, Engle, Logan L., Sunshine, Joel C., Wang, Hao, Pandya, Dimple, Baxi, Vipul, Fiore, Joseph, Sidik, Kurex, Pratt, James, Baras, Alexander S., Cottrell, Tricia R., and Taube, Janis M.

Published
2025
Full Text
View/download PDF

8. RNA Sequencing Identifies Frequent Mitogen-activated Protein Kinase–associated Fusion Genes in Intraductal Tubulopapillary Neoplasms of the Pancreas

Author

Tucker, James, Zureikat, Amer H., He, Jin, Paniccia, Alessandro, Lee, Kenneth K., Zeh, Herbert J., Hogg, Melissa E., Dasyam, Anil K., McGrath, Kevin, Lennon, Anne Marie, Fasanella, Kenneth E., Afghani, Elham, Brand, Randall E., Slivka, Adam, Kubiliun, Nisa, VandenBussche, Christopher J., Thompson, Elizabeth D., Torbenson, Michael S., Allende, Daniela S., Bell, Phoenix D., Kaya, Cihan, Wald, Abigail I., Lee, Jae W., Hruban, Ralph H., Brosens, Lodewijk A.A., Condello, Vincenzo, Nikiforova, Marina N., and Singhi, Aatur D.

Published
2023
Full Text
View/download PDF

11. Prospective, Multi-Institutional, Real-Time Next-Generation Sequencing of Pancreatic Cyst Fluid Reveals Diverse Genomic Alterations That Improve the Clinical Management of Pancreatic Cysts

Author

Paniccia, Alessandro, Polanco, Patricio M., Boone, Brian A., Wald, Abigail I., McGrath, Kevin, Brand, Randall E., Khalid, Asif, Kubiliun, Nisa, O'Broin-Lennon, Anne Marie, Park, Walter G., Klapman, Jason, Tharian, Benjamin, Inamdar, Sumant, Fasanella, Kenneth, Nasr, John, Chennat, Jennifer, Das, Rohit, DeWitt, John, Easler, Jeffrey J., Bick, Benjamin, Singh, Harkirat, Fairley, Kimberly J., Sarkaria, Savreet, Sawas, Tarek, Skef, Wasseem, Slivka, Adam, Tavakkoli, Anna, Thakkar, Shyam, Kim, Victoria, Vanderveldt, Hendrikus Dutch, Richardson, Allyson, Wallace, Michael B., Brahmbhatt, Bhaumik, Engels, Megan, Gabbert, Charles, Dugum, Mohannad, El-Dika, Samer, Bhat, Yasser, Ramrakhiani, Sanjay, Bakis, Gennadiy, Rolshud, Daniil, Millspaugh, Gordon, Tielleman, Thomas, Schmidt, Carl, Mansour, John, Marsh, Wallis, Ongchin, Melanie, Centeno, Barbara, Monaco, Sara E., Ohori, N. Paul, Lajara, Sigfred, Thompson, Elizabeth D., Hruban, Ralph H., Bell, Phoenix D., Smith, Katelyn, Permuth, Jennifer B., Vandenbussche, Christopher, Ernst, Wayne, Grupillo, Maria, Kaya, Cihan, Hogg, Melissa, He, Jin, Wolfgang, Christopher L., Lee, Kenneth K., Zeh, Herbert, Zureikat, Amer, Nikiforova, Marina N., and Singhi, Aatur D.

Published
2023
Full Text
View/download PDF

13. The Impact of the COVID-19 Pandemic on Multidisciplinary Clinics: A High-Volume Pancreatic Cancer Center Experience

Author

Javed, Ammar A., Habib, Joseph R., Kinny-Köster, Benedict, Hodgin, Mary, Parish, Lindsay, Cunningham, Dea, Hacker-Prietz, Amy, Burkhart, Richard A., Burns, William R., Shubert, Christopher R., Cameron, John L., Zaheer, Atif, Chu, Linda C.H., Kawamoto, Satomi, Thompson, Elizabeth D., Shin, Eun J., Narang, Amol, Zheng, Lei, Laheru, Daniel A., Hruban, Ralph H., He, Jin, Wolfgang, Christopher L., Fishman, Elliot K., and Lafaro, Kelly

Published
2022
Full Text
View/download PDF

15. Supplementary Table S4 from Fibroblasts in the Aged Pancreas Drive Pancreatic Cancer Progression

Author

Zabransky, Daniel J., primary, Chhabra, Yash, primary, Fane, Mitchell E., primary, Kartalia, Emma, primary, Leatherman, James M., primary, Hüser, Laura, primary, Zimmerman, Jacquelyn W., primary, Delitto, Daniel, primary, Han, Song, primary, Armstrong, Todd D., primary, Charmsaz, Soren, primary, Guinn, Samantha, primary, Pramod, Sneha, primary, Thompson, Elizabeth D., primary, Hughes, Steven J., primary, O'Connell, Jennifer, primary, Egan, Josephine M., primary, Jaffee, Elizabeth M., primary, and Weeraratna, Ashani T., primary

Published
2024
Full Text
View/download PDF

16. Figure S2 from Fibroblasts in the Aged Pancreas Drive Pancreatic Cancer Progression

Author

Zabransky, Daniel J., primary, Chhabra, Yash, primary, Fane, Mitchell E., primary, Kartalia, Emma, primary, Leatherman, James M., primary, Hüser, Laura, primary, Zimmerman, Jacquelyn W., primary, Delitto, Daniel, primary, Han, Song, primary, Armstrong, Todd D., primary, Charmsaz, Soren, primary, Guinn, Samantha, primary, Pramod, Sneha, primary, Thompson, Elizabeth D., primary, Hughes, Steven J., primary, O'Connell, Jennifer, primary, Egan, Josephine M., primary, Jaffee, Elizabeth M., primary, and Weeraratna, Ashani T., primary

Published
2024
Full Text
View/download PDF

17. Table S2 from Fibroblasts in the Aged Pancreas Drive Pancreatic Cancer Progression

Author

Zabransky, Daniel J., primary, Chhabra, Yash, primary, Fane, Mitchell E., primary, Kartalia, Emma, primary, Leatherman, James M., primary, Hüser, Laura, primary, Zimmerman, Jacquelyn W., primary, Delitto, Daniel, primary, Han, Song, primary, Armstrong, Todd D., primary, Charmsaz, Soren, primary, Guinn, Samantha, primary, Pramod, Sneha, primary, Thompson, Elizabeth D., primary, Hughes, Steven J., primary, O'Connell, Jennifer, primary, Egan, Josephine M., primary, Jaffee, Elizabeth M., primary, and Weeraratna, Ashani T., primary

Published
2024
Full Text
View/download PDF

18. Data from Fibroblasts in the Aged Pancreas Drive Pancreatic Cancer Progression

Author

Zabransky, Daniel J., primary, Chhabra, Yash, primary, Fane, Mitchell E., primary, Kartalia, Emma, primary, Leatherman, James M., primary, Hüser, Laura, primary, Zimmerman, Jacquelyn W., primary, Delitto, Daniel, primary, Han, Song, primary, Armstrong, Todd D., primary, Charmsaz, Soren, primary, Guinn, Samantha, primary, Pramod, Sneha, primary, Thompson, Elizabeth D., primary, Hughes, Steven J., primary, O'Connell, Jennifer, primary, Egan, Josephine M., primary, Jaffee, Elizabeth M., primary, and Weeraratna, Ashani T., primary

Published
2024
Full Text
View/download PDF

19. Ovarian Metastasis from Pancreatic Ductal Adenocarcinoma

Author

Habib, Joseph R., Pasha, Shamsher, Khan, Subhan, Kinny-Köster, Benedict, Shoucair, Sami, Thompson, Elizabeth D., Yu, Jun, Lafaro, Kelly, Burkhart, Richard A., Burns, William R., Ronnett, Brigitte M., Wolfgang, Christopher L., Hruban, Ralph H., He, Jin, Fishman, Elliot K., and Javed, Ammar A.

Published
2021
Full Text
View/download PDF

20. Continuing Undergraduate Pathology Medical Education in the Coronavirus Disease 2019 (COVID-19) Global Pandemic: The Johns Hopkins Virtual Surgical Pathology Clinical Elective

Author

White, Marissa J., Birkness, Jacqueline E., Salimian, Kevan J., Meiss, Alice E., Butcher, Monica, Davis, Katelynn, Ware, Alisha D., Zarella, Mark D., Lecksell, Kristen, Rooper, Lisa M., Cimino-Mathews, Ashley, VandenBussche, Christopher J., Halushka, Marc K., and Thompson, Elizabeth D.

Subjects
Diagnosis, Surgical -- Study and teaching, Epidemics -- Educational aspects, Pathology -- Study and teaching, Medical education -- Technology application, Medical personnel -- Training, Online education -- Methods, Company business management, Technology application, Health, Johns Hopkins University. School of Medicine -- Technology application -- Management
Abstract

* Context.--In the early months of the response to the coronavirus disease 2019 (COVID-19) pandemic, the Johns Hopkins University School of Medicine (JHUSOM) (Baltimore, Maryland) leadership reached out to faculty to develop and implement virtual clinical clerkships after all in-person medical student clinical experiences were suspended. Objective.--To develop and implement a digital slide-based virtual surgical pathology (VSP) clinical elective to meet the demand for meaningful and robust virtual clinical electives in response to the temporary suspension of in-person clinical rotations at JHUSOM. Design.--The VSP elective was modeled after the in-person surgical pathology elective to include virtual previewing and sign-out with standardized cases supplemented by synchronous and asynchronous pathology educational content. Results.--Validation of existing Web communications technology and slide-scanning systems was performed by feasibility testing. Curriculum development included drafting of course objectives and syllabus, Blackboard course site design, electronic-lecture creation, communications with JHUSOM leadership, scheduling, and slide curation. Subjectively, the weekly schedule averaged 35 to 40 hours of asynchronous, synchronous, and independent content, approximately 10 to 11 hours of which were synchronous. As of February 2021, VSP has hosted 35 JHUSOM and 8 non-JHUSOM students, who have provided positive subjective and objective course feedback. Conclusions.--The Johns Hopkins VSP elective provided meaningful clinical experience to 43 students in a time of immense online education need. Added benefits of implementing VSP included increased medical student exposure to pathology as a medical specialty and demonstration of how digital slides have the potential to improve standardization of the pathology clerkship curriculum. (Arch Pathol Lab Med. 2021;145:814-820; doi: 10.5858/arpa.2020-0652-SA), On March 10, 2020, Johns Hopkins University (Baltimore, Maryland) President Ronald J. Daniels announced the suspension of in-person classes for all students, with Johns Hopkins University and Johns Hopkins Medicine [...]

Published
2021
Full Text
View/download PDF

27. Neoadjuvant radioimmunotherapy in pancreatic cancer enhances effector T cell infiltration and shortens their distances to tumor cells

Author

Wang, Junke, primary, Gai, Jessica, additional, Zhang, Tengyi, additional, Niu, Nan, additional, Qi, Hanfei, additional, Thomas, Dwayne L., additional, Li, Keyu, additional, Xia, Tao, additional, Rodriguez, Christina, additional, Parkinson, Rose, additional, Durham, Jennifer, additional, McPhaul, Thomas, additional, Narang, Amol K., additional, Anders, Robert A., additional, Osipov, Arsen, additional, Wang, Hao, additional, He, Jin, additional, Laheru, Daniel A., additional, Herman, Joseph M., additional, Lee, Valerie, additional, Jaffee, Elizabeth M., additional, Thompson, Elizabeth D., additional, Zhu, Qingfeng, additional, and Zheng, Lei, additional

Published
2024
Full Text
View/download PDF

29. Pancreatic Neoplasms With Acinar Differentiation: A Review of Pathologic and Molecular Features

Author

Thompson, Elizabeth D. and Wood, Laura D.

Subjects
Pancreatic cancer -- Diagnosis, Health
Abstract

* Context.--Pancreatic acinar lesions encompass a broad spectrum of malignant tumors and benign reactive processes affecting both adults and children, with clinical, pathologic, and molecular features that are distinct from more common ductal neoplasms. Accurate morphologic diagnosis and molecular assessment of these uncommon neoplasms is critical for effective patient care. Objective.--To review the clinical, pathologic, and molecular features of pancreatic neoplasms with acinar differentiation, the most common of which is acinar cell carcinoma but which also includes mixed carcinomas with acinar components, cystic acinar lesions, and pancreatoblastoma. Data Sources.--We assessed the current primary literature, as well as recently updated diagnostic manuals. Conclusions.--Pancreatic acinar neoplasms are a morphologically and molecularly heterogeneous group of diseases that are characterized by acinar differentiation of at least a subset of the neoplastic cells, defined either morphologically (granular cytoplasm, single prominent nucleoli) or immunohistochemically. Squamoid nests are a key morphologic feature of pancreatoblastoma. Alterations in WNT signaling and chromosomal 11p loss are common molecular features of both acinar cell carcinoma and pancreatoblastoma. Targetable molecular alterations in acinar carcinoma include BRAF rearrangements and DNA repair defects, including mismatch repair deficiency and BRCA pathway defects. For practicing pathologists, morphologic recognition of such acinar neoplasms is critical, and in the future, molecular diagnostics to identify lesions susceptible to targeted therapy will likely form an important component of patient care. (Arch Pathol Lab Med. 2020;144:808-815; doi: 10.5858/arpa.2019-0472-RA), Pancreatic acinar lesions are clinically and pathologically distinct from more common ductal neoplasms, encompassing a broad spectrum of malignant tumors and benign reactive processes affecting both adults and children. Knowledge [...]

Published
2020
Full Text
View/download PDF

30. RAD51B Harbors Germline Mutations Associated With Pancreatic Ductal Adenocarcinoma

Author

Xie, Fanfan, Ding, Ding, Lin, Cong, Cunningham, Dea, Wright, Michael, Javed, Ammar A., Azad, Nilo, Lee, Valerie, Donehower, Ross, De Jesus-Acosta, Ana, Le, Dung T., Pishvaian, Michael, Shin, Eun Ji, Lennon, Anne Marie, Khashab, Mouen, Singh, Vikesh, Klein, Alison P., Roberts, Nicholas J., Hacker-Prietz, Amy, McPhaul, Thomas, Burkhart, Richard A., Burns, William R., Narang, Amol, Zaheer, Atif, Fishman, Elliot K., Thompson, Elizabeth D., Anders, Robert, Yu, Jun, He, Jin, Wolfgang, Christopher L., Zheng, Lei, Liu, Dongbing, Wu, Kui, and Laheru, Daniel A.

Published
2022
Full Text
View/download PDF

33. Multi-omic profiling of lung and liver tumor microenvironments of metastatic pancreatic cancer reveals site-specific immune regulatory pathways

Author

Ho, Won Jin, Erbe, Rossin, Danilova, Ludmila, Phyo, Zaw, Bigelow, Emma, Stein-O’Brien, Genevieve, Thomas, II, Dwayne L., Charmsaz, Soren, Gross, Nicole, Woolman, Skylar, Cruz, Kayla, Munday, Rebecca M., Zaidi, Neeha, Armstrong, Todd D., Sztein, Marcelo B., Yarchoan, Mark, Thompson, Elizabeth D., Jaffee, Elizabeth M., and Fertig, Elana J.

Published
2021
Full Text
View/download PDF

34. The Impact of Clinical and Pathological Features on Intraductal Papillary Mucinous Neoplasm Recurrence After Surgical Resection: Long-Term Follow-Up Analysis

Author

Pflüger, Michael J., Griffin, James F., Hackeng, Wenzel M., Kawamoto, Satomi, Yu, Jun, Chianchiano, Peter, Shin, Eunice, Lionheart, Gemma, Tsai, Hua-Ling, Wang, Hao, Rezaee, Neda, Burkhart, Richard A., Cameron, John L., Thompson, Elizabeth D., Wolfgang, Christopher L., He, Jin, Brosens, Lodewijk A. A., and Wood, Laura D.

Published
2020
Full Text
View/download PDF

35. Digitize your Biology! Modeling multicellular systems through interpretable cell behavior

Author

Johnson, Jeanette A.I., primary, Stein-O'Brien, Genevieve L, additional, Booth, Max, additional, Heiland, Randy, additional, Kurtoglu, Furkan, additional, Bergman, Daniel, additional, Bucher, Elmar, additional, Deshpande, Atul, additional, Forjaz, Andre, additional, Getz, Michael, additional, Godet, Ines, additional, Lyman, Melissa, additional, Metzcar, John, additional, Mitchell, Jacob, additional, Raddatz, Andrew, additional, Rocha, Heber L., additional, Solorzano, Jacobo, additional, Sundus, Aneequa, additional, Wang, Yafei, additional, Gilkes, Daniele M., additional, Kagohara, Luciane T., additional, Kiemen, Ashley L., additional, Thompson, Elizabeth D., additional, Wirtz, Denis, additional, Wu, Pei-Hsun, additional, Zaidi, Neeha, additional, Zheng, Lei, additional, Zimmerman, Jacquelyn W., additional, Jaffee, Elizabeth M., additional, Chang, Young Hwan, additional, Coussens, Lisa, additional, Gray, Joe, additional, Heiser, Laura M., additional, Fertig, Elana J., additional, and Macklin, Paul, additional

Published
2023
Full Text
View/download PDF

39. Genomic characterization of malignant progression in neoplastic pancreatic cysts

Author

Noë, Michaël, Niknafs, Noushin, Fischer, Catherine G., Hackeng, Wenzel M., Beleva Guthrie, Violeta, Hosoda, Waki, Debeljak, Marija, Papp, Eniko, Adleff, Vilmos, White, James R., Luchini, Claudio, Pea, Antonio, Scarpa, Aldo, Butturini, Giovanni, Zamboni, Giuseppe, Castelli, Paola, Hong, Seung-Mo, Yachida, Shinichi, Hiraoka, Nobuyoshi, Gill, Anthony J., Samra, Jaswinder S., Offerhaus, G. Johan A., Hoorens, Anne, Verheij, Joanne, Jansen, Casper, Adsay, N. Volkan, Jiang, Wei, Winter, Jordan, Albores-Saavedra, Jorge, Terris, Benoit, Thompson, Elizabeth D., Roberts, Nicholas J., Hruban, Ralph H., Karchin, Rachel, Scharpf, Robert B., Brosens, Lodewijk A. A., Velculescu, Victor E., and Wood, Laura D.

Published
2020
Full Text
View/download PDF

40. Immune microenvironment of intimal sarcomas: Adaptive immune resistance with potential therapeutic implications.

Author

Birkness-Gartman, Jacqueline E, Thomas, Dwayne L, Engle, Logan L, Voltaggio, Lysandra, and Thompson, Elizabeth D

Subjects
PROGRAMMED death-ligand 1, BIOMARKERS, SARCOMA
Abstract

Objectives Intimal sarcomas are rare, aggressive neoplasms that arise from large blood vessels. Characterization of the tumor immune microenvironment may suggest new treatment strategies. Methods Seventeen specimens from 7 patients were labeled by immunohistochemistry for programmed cell death 1 ligand 1 (PD-L1), CD45, CD8, CD4, FOXP3, CD20, CD68, and LAG3. The immune cell density was scored as a percentage of the tumor area (1+ [<5%], 2+ [5%-50%], 3+ [>50%]); PD-L1 expression was scored on tumor cells and on intratumoral immune cells. Immune marker density was quantified using image analysis software. Results All intimal sarcomas showed immune cell infiltration (41% were 1+, 53% were 2+, 6% were 3+). Tumor and immune cell PD-L1 labeling was seen in 35% and 76% of cases, respectively; PD-L1+ intimal sarcomas had higher CD45+, CD8+, FOXP3+, CD68+, and leukocyte activation gene 3 (LAG3)+ cell densities (P  ≤ .01). Similarly, PD-L1 expression on immune cells correlated with higher densities of CD8+ and FOXP3+ cells (P  < .04). Higher LAG3+ cell density correlated with higher CD68+ cell density and necrosis (P  < .05). One patient with prolonged survival had the highest immune cell density and PD-L1 expression. Conclusions These data show that intimal sarcomas have an active tumor microenvironment with an adaptive pattern of PD-L1 expression. Our results suggest that immunotherapy may be an effective treatment option. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

41. Characterizing the impact of multiple chronic conditions on return to participation in chronic stroke survivors.

Author

Thompson, Elizabeth D., Miller, Allison E., and Reisman, Darcy S.

Subjects
STROKE prevention, CHRONIC diseases, CROSS-sectional method, RETROSPECTIVE studies, REGRESSION analysis, SELF-efficacy, RESEARCH funding, QUALITY of life, DATA analysis software
Abstract

Each year, 795,000 Americans experience a stroke. As stroke mortality declines, more individuals are in the chronic phase of recovery (>6 months post-stroke). Over 80% of stroke survivors have multiple, chronic health conditions (MCC). While the relationship between MCC and mortality and function during acute recovery has been explored, less is known about how MCC burden affects participation in chronic stroke survivors. This study investigated whether MCC burden is related to participation in those with chronic stroke. Two hundred and sixty-six participants with chronic (≥6 months) stroke were included in this cross-sectional and retrospective analysis. Participants had a mean age of 62.2 ± 12.8 years, and time since stroke (TSS) of 36.0 ± 44.6 months (114F/152 M). Participants completed the 6-minute Walk Test (6MWT), Activities-Specific Balance Confidence Scale (ABC), Modified Cumulative Illness Rating Scale (MCIR) to quantify the presence and severity of chronic illness across 14 body systems, and the Stroke Impact Scale – Participation subscale (SIS-P). Participation (SIS-P) was the dependent variable. Independent variables were entered into a sequential regression model in three blocks: demographic variables, physical capacity (6MWT distance) and balance self-efficacy (ABC), and MCC burden (MCIR). After adjusting for age, sex, and time since stroke, physical capacity and balance self-efficacy explained 31.4% (p < 0.001), and the MCC burden explained 2.0% (p = 0.004). Higher participation was related to lower MCC burden. MCC burden is a significant contributor to variance in participation in chronic stroke survivors, above and beyond demographics, physical capacity, and self-efficacy, and therefore should be considered when creating rehabilitation programs to improve participation. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results