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1. R2d2 Drives Selfish Sweeps in the House Mouse.

Author

Didion, John, Morgan, Andrew, Yadgary, Liran, Bell, Timothy, McMullan, Rachel, Ortiz de Solorzano, Lydia, Britton-Davidian, Janice, Bult, Carol, Campbell, Karl, Castiglia, Riccardo, Ching, Yung-Hao, Chunco, Amanda, Crowley, James, Chesler, Elissa, Förster, Daniel, French, John, Gabriel, Sofia, Gatti, Daniel, Garland, Theodore, Giagia-Athanasopoulou, Eva, Giménez, Mabel, Grize, Sofia, Gündüz, İslam, Holmes, Andrew, Hauffe, Heidi, Herman, Jeremy, Holt, James, Hua, Kunjie, Jolley, Wesley, Lindholm, Anna, López-Fuster, María, Mitsainas, George, da Luz Mathias, Maria, McMillan, Leonard, Ramalhinho, Maria, Rehermann, Barbara, Rosshart, Stephan, Searle, Jeremy, Shiao, Meng-Shin, Solano, Emanuela, Svenson, Karen, Thomas-Laemont, Patricia, Threadgill, David, Ventura, Jacint, Weinstock, George, Pomp, Daniel, Churchill, Gary, and Pardo-Manuel de Villena, Fernando

Subjects
House Mouse., Meiotic Drive, R2d2, Selective Sweep, Selfish Genes, Adaptation, Physiological, Alleles, Animals, Biological Evolution, DNA Copy Number Variations, Evolution, Molecular, Female, Genetic Variation, Genetics, Population, Male, Mice, Models, Genetic, Mutation, Nuclear Proteins, RNA-Binding Proteins, Repetitive Sequences, Nucleic Acid, Selection, Genetic
Abstract

A selective sweep is the result of strong positive selection driving newly occurring or standing genetic variants to fixation, and can dramatically alter the pattern and distribution of allelic diversity in a population. Population-level sequencing data have enabled discoveries of selective sweeps associated with genes involved in recent adaptations in many species. In contrast, much debate but little evidence addresses whether selfish genes are capable of fixation-thereby leaving signatures identical to classical selective sweeps-despite being neutral or deleterious to organismal fitness. We previously described R2d2, a large copy-number variant that causes nonrandom segregation of mouse Chromosome 2 in females due to meiotic drive. Here we show population-genetic data consistent with a selfish sweep driven by alleles of R2d2 with high copy number (R2d2(HC)) in natural populations. We replicate this finding in multiple closed breeding populations from six outbred backgrounds segregating for R2d2 alleles. We find that R2d2(HC) rapidly increases in frequency, and in most cases becomes fixed in significantly fewer generations than can be explained by genetic drift. R2d2(HC) is also associated with significantly reduced litter sizes in heterozygous mothers, making it a true selfish allele. Our data provide direct evidence of populations actively undergoing selfish sweeps, and demonstrate that meiotic drive can rapidly alter the genomic landscape in favor of mutations with neutral or even negative effects on overall Darwinian fitness. Further study will reveal the incidence of selfish sweeps, and will elucidate the relative contributions of selfish genes, adaptation and genetic drift to evolution.

Published
2016

2. R2d2 drives selfish sweeps in the house mouse

Author

Didion, John P, Morgan, Andrew P, Yadgary, Liran, Bell, Timothy A, McMullan, Rachel C, de Solorzano, Lydia Ortiz, Britton-Davidian, Janice, Bult, Carol J, Campbell, Karl J, Castiglia, Riccardo, Ching, Yung-Hao, Chunco, Amanda J, Crowley, James J, Chesler, Elissa J, Förster, Daniel W, French, John E, Gabriel, Sofia I, Gatti, Daniel M, Garland, Theodore, Giagia-Athanasopoulou, Eva B, Giménez, Mabel D, Grize, Sofia A, Günduz, Islam, Holmes, Andrew, Hauffe, Heidi C, Herman, Jeremy S, Holt, James M, Hua, Kunjie, Jolley, Wesley J, Lindholm, Anna K, Lopez-Fuster, Maria J, Mitsainas, George, da Luz Mathias, Maria, McMillan, Leonard, da Graca Morgado Ramalhinho, Maria, Rehermann, Barbara, Rosshart, Stephan P, Searle, Jeremy B, Shiao, Meng-Shin, Solano, Emanuela, Svenson, Karen L, Thomas-Laemont, Patricia, Threadgill, David W, Ventura, Jacint, Weinstock, George M, Pomp, Daniel, Churchill, Gary A, de Villena, Fernando Pardo-Manuel, Didion, John P, Morgan, Andrew P, Yadgary, Liran, Bell, Timothy A, McMullan, Rachel C, de Solorzano, Lydia Ortiz, Britton-Davidian, Janice, Bult, Carol J, Campbell, Karl J, Castiglia, Riccardo, Ching, Yung-Hao, Chunco, Amanda J, Crowley, James J, Chesler, Elissa J, Förster, Daniel W, French, John E, Gabriel, Sofia I, Gatti, Daniel M, Garland, Theodore, Giagia-Athanasopoulou, Eva B, Giménez, Mabel D, Grize, Sofia A, Günduz, Islam, Holmes, Andrew, Hauffe, Heidi C, Herman, Jeremy S, Holt, James M, Hua, Kunjie, Jolley, Wesley J, Lindholm, Anna K, Lopez-Fuster, Maria J, Mitsainas, George, da Luz Mathias, Maria, McMillan, Leonard, da Graca Morgado Ramalhinho, Maria, Rehermann, Barbara, Rosshart, Stephan P, Searle, Jeremy B, Shiao, Meng-Shin, Solano, Emanuela, Svenson, Karen L, Thomas-Laemont, Patricia, Threadgill, David W, Ventura, Jacint, Weinstock, George M, Pomp, Daniel, Churchill, Gary A, and de Villena, Fernando Pardo-Manuel

Abstract

A selective sweep is the result of strong positive selection driving newly occurring or standing genetic variants to fixation, and can dramatically alter the pattern and distribution of allelic diversity in a population. Population-level sequencing data have enabled discoveries of selective sweeps associated with genes involved in recent adaptations in many species. In contrast, much debate but little evidence addresses whether “selfish” genes are capable of fixation – thereby leaving signatures identical to classical selective sweeps – despite being neutral or deleterious to organismal fitness. We previously described R2d2, a large copy-number variant that causes non-random segregation of mouse Chromosome 2 in females due to meiotic drive. Here we show population-genetic data consistent with a selfish sweep driven by alleles of R2d2 with high copy number (R2d2HC) in natural populations. We replicate this finding in multiple closed breeding populations from six outbred backgrounds segregating for R2d2 alleles. We find that R2d2HC rapidly increases in frequency, and in most cases becomes fixed in significantly fewer generations than can be explained by genetic drift. R2d2HC is also associated with significantly reduced litter sizes in heterozygous mothers, making it a true selfish allele. Our data provide direct evidence of populations actively undergoing selfish sweeps, and demonstrate that meiotic drive can rapidly alter the genomic landscape in favor of mutations with neutral or even negative effects on overall Darwinian fitness. Further study will reveal the incidence of selfish sweeps, and will elucidate the relative contributions of selfish genes, adaptation and genetic drift to evolution.

Published
2016

3. R2d2Drives Selfish Sweeps in the House Mouse

Author

Didion, John P., primary, Morgan, Andrew P., additional, Yadgary, Liran, additional, Bell, Timothy A., additional, McMullan, Rachel C., additional, Ortiz de Solorzano, Lydia, additional, Britton-Davidian, Janice, additional, Bult, Carol J., additional, Campbell, Karl J., additional, Castiglia, Riccardo, additional, Ching, Yung-Hao, additional, Chunco, Amanda J., additional, Crowley, James J., additional, Chesler, Elissa J., additional, Förster, Daniel W., additional, French, John E., additional, Gabriel, Sofia I., additional, Gatti, Daniel M., additional, Garland, Theodore, additional, Giagia-Athanasopoulou, Eva B., additional, Giménez, Mabel D., additional, Grize, Sofia A., additional, Gündüz, İslam, additional, Holmes, Andrew, additional, Hauffe, Heidi C., additional, Herman, Jeremy S., additional, Holt, James M., additional, Hua, Kunjie, additional, Jolley, Wesley J., additional, Lindholm, Anna K., additional, López-Fuster, María J., additional, Mitsainas, George, additional, da Luz Mathias, Maria, additional, McMillan, Leonard, additional, Ramalhinho, Maria da Graça Morgado, additional, Rehermann, Barbara, additional, Rosshart, Stephan P., additional, Searle, Jeremy B., additional, Shiao, Meng-Shin, additional, Solano, Emanuela, additional, Svenson, Karen L., additional, Thomas-Laemont, Patricia, additional, Threadgill, David W., additional, Ventura, Jacint, additional, Weinstock, George M., additional, Pomp, Daniel, additional, Churchill, Gary A., additional, and Pardo-Manuel de Villena, Fernando, additional

Published
2016
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5. Small Mammal Community Structure on a North Carolina Old Field Successional Plot.

Author

Salecki, Emmanuela, Chunco, Amanda, and Thomas-Laemont, Patricia

Subjects
MAMMAL communities, MAMMAL habitats, MAMMAL diversity, HORSE feeding & feeds
Abstract

Old field successional plots of land are an interesting area of study because the diversity of plant and animal life change depending on which period of succession you are studying. While primary succession, such as Mount St. Helens and soils exposed during glacial retreats show the most dramatic changes in biodiversity over time, succession in old farm fields can also bring about a large turnover in biodiversity over a relatively short period of time. Our research focuses specifically on small mammals on old-field successional habitat. We set up a 100 x 90-meter plot with 90 trapping stations arranged at 10m x 10m intervals at Elon University's Loy Farm. Aluminum Sherman Folding Small Mammal Traps were used in order to capture the small mammals. Traps of three sizes (Small, Medium, and Large) were used, with medium traps at every trapping station and small and large traps interspersed throughout the field. Small traps would be either set flush with the ground or elevated on a wooden stake. These traps were placed as such in order to catch field mice, which generally jump or climb. The bait used in the traps was a mixture of creamy peanut butter and horse feed oats wrapped in wax paper into a "kiss" and hung at the back of the trap. On trap days, traps would be opened at approximately 0800 and then subsequently checked for mammals at approximately 1400 the same day. Trap number, weight, length, sex, mating condition, unique individual details, and tag number if present were recorded for each small mammal captured. New captures received an ear tag. The goal of this research was to examine the small mammal community in a secondary successional field in the Piedmont of North Carolina. [ABSTRACT FROM AUTHOR]

Published
2021

6. Male accessory gland factors elicit change from `virgin' to `mated' behaviour in the female corn...

Author

Kingan, Timothy G. and Thomas-Laemont, Patricia A.

Subjects
*LEPIDOPTERA, *HELIOTHIS zea
Abstract

Investigates the behavioral effects of chemical messengers in the seminal fluids of Lepidoptera. Actions of male accessory glands of the corn earworm moth Helicoverpa zea in the evoking of different components of the mated state of females; Explanation for the transient depletion of pheromone after mating.

Published
1993
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7. R2d2 Drives Selfish Sweeps in the House Mouse

Author

Searle, Jeremy B., Didion, John P., Pomp, Daniel, Solano, Emanuela, López-Fuster, María J., Ventura, Jacint, Ramalhinho, Maria Da Graça Morgado, Churchill, Gary A., Morgan, Andrew P., McMullan, Rachel C., Giménez, Mabel D., Ching, Yung-Hao, Garland, Theodore, Castiglia, Riccardo, Bult, Carol J., Gündüz, Islam, Bell, Timothy A., Grize, Sofia A., Chesler, Elissa J., Lindholm, Anna K., Weinstock, George M., Gatti, Daniel M., Hauffe, Heidi C., Förster, Daniel W., French, John E., Da Luz Mathias, Maria, Holmes, Andrew, Giagia-Athanasopoulou, Eva B., Mitsainas, George, De Solorzano, Lydia Ortiz, Rehermann, Barbara, Rosshart, Stephan P., De Villena, Fernando Pardo-Manuel, Chunco, Amanda J., Britton-Davidian, Janice, Threadgill, David W., Svenson, Karen L., Holt, James M., Gabriel, Sofia I., Shiao, Meng-Shin, Crowley, James J., Campbell, Karl J., Hua, Kunjie, McMillan, Leonard, Jolley, Wesley J., Herman, Jeremy S., Yadgary, Liran, and Thomas-Laemont, Patricia

Subjects
2. Zero hunger
Abstract

A selective sweep is the result of strong positive selection driving newly occurring or standing genetic variants to fixation, and can dramatically alter the pattern and distribution of allelic diversity in a population. Population-level sequencing data have enabled discoveries of selective sweeps associated with genes involved in recent adaptations in many species. In contrast, much debate but little evidence addresses whether “selfish” genes are capable of fixation—thereby leaving signatures identical to classical selective sweeps—despite being neutral or deleterious to organismal fitness. We previously described R2d2, a large copy-number variant that causes nonrandom segregation of mouse Chromosome 2 in females due to meiotic drive. Here we show population-genetic data consistent with a selfish sweep driven by alleles of R2d2 with high copy number (R2d2HC) in natural populations. We replicate this finding in multiple closed breeding populations from six outbred backgrounds segregating for R2d2 alleles. We find that R2d2HC rapidly increases in frequency, and in most cases becomes fixed in significantly fewer generations than can be explained by genetic drift. R2d2HC is also associated with significantly reduced litter sizes in heterozygous mothers, making it a true selfish allele. Our data provide direct evidence of populations actively undergoing selfish sweeps, and demonstrate that meiotic drive can rapidly alter the genomic landscape in favor of mutations with neutral or even negative effects on overall Darwinian fitness. Further study will reveal the incidence of selfish sweeps, and will elucidate the relative contributions of selfish genes, adaptation and genetic drift to evolution.

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