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1. Table S1 from The Tumor Immune Microenvironment Drives a Prognostic Relevance That Correlates with Bladder Cancer Subtypes

Author

Markus Eckstein, Reiner Strick, Arndt Hartmann, Philipp Erben, Franziska Erlmeier, Bastian Keck, Simone Bertz, Robert Stoehr, Veronika Weyerer, Carol I. Geppert, Nicole Fuhrich, Christian Bolenz, Bernd Wullich, Maximilian Burger, Thomas Worst, Wolfgang Otto, Johannes Breyer, Helge Taubert, Adrian Wullweber, Ralph M. Wirtz, Sven Wach, Danijel Sikic, Katherine B. Chiappinelli, Pamela L. Strissel, and Carolin Pfannstiel

Abstract

Clinico-pathological features of analyzed cohorts and subgroups.

Published
2023

2. Table S5 from The Tumor Immune Microenvironment Drives a Prognostic Relevance That Correlates with Bladder Cancer Subtypes

Author

Markus Eckstein, Reiner Strick, Arndt Hartmann, Philipp Erben, Franziska Erlmeier, Bastian Keck, Simone Bertz, Robert Stoehr, Veronika Weyerer, Carol I. Geppert, Nicole Fuhrich, Christian Bolenz, Bernd Wullich, Maximilian Burger, Thomas Worst, Wolfgang Otto, Johannes Breyer, Helge Taubert, Adrian Wullweber, Ralph M. Wirtz, Sven Wach, Danijel Sikic, Katherine B. Chiappinelli, Pamela L. Strissel, and Carolin Pfannstiel

Abstract

Distribution of stromal tumor infiltrating lymphocytes in analyzed cohorts and subgroups.

Published
2023

3. Supplementary Figure S1-S7 from The Tumor Immune Microenvironment Drives a Prognostic Relevance That Correlates with Bladder Cancer Subtypes

Author

Markus Eckstein, Reiner Strick, Arndt Hartmann, Philipp Erben, Franziska Erlmeier, Bastian Keck, Simone Bertz, Robert Stoehr, Veronika Weyerer, Carol I. Geppert, Nicole Fuhrich, Christian Bolenz, Bernd Wullich, Maximilian Burger, Thomas Worst, Wolfgang Otto, Johannes Breyer, Helge Taubert, Adrian Wullweber, Ralph M. Wirtz, Sven Wach, Danijel Sikic, Katherine B. Chiappinelli, Pamela L. Strissel, and Carolin Pfannstiel

Abstract

Figure S1. Selected images of different sTILs amounts, illustration of applied scoring method and images of IHC stainings. Figure S2. TLS in MIBC Figure S3. Subtyping of the CCC-EMN cohort and the TCGA-Cohort according to the MDACC-subtyping gene signature Figure S4. TCGA-Basal tumors (n=142). CIBERSORT and Mutational Burden. Figure S5. TCGA Luminal tumors (n=243). CIBERSORT and Mutational Burden. Figure S6. Distribution of tumor mutational burden (TMB; based on total single nucleotide variants) and neoantigens among different cut-offs of stromal TILs. Figure S7. TCGA - Antigen presenting cell signature (AGPS) and combined adjuvant platinum-containing chemotherapy cohort.

Published
2023

4. Table S3 from The Tumor Immune Microenvironment Drives a Prognostic Relevance That Correlates with Bladder Cancer Subtypes

Author

Markus Eckstein, Reiner Strick, Arndt Hartmann, Philipp Erben, Franziska Erlmeier, Bastian Keck, Simone Bertz, Robert Stoehr, Veronika Weyerer, Carol I. Geppert, Nicole Fuhrich, Christian Bolenz, Bernd Wullich, Maximilian Burger, Thomas Worst, Wolfgang Otto, Johannes Breyer, Helge Taubert, Adrian Wullweber, Ralph M. Wirtz, Sven Wach, Danijel Sikic, Katherine B. Chiappinelli, Pamela L. Strissel, and Carolin Pfannstiel

Abstract

CIBERSORT - Spearman rank correlations between predicted immune cell populations in the TCGA cohort.

Published
2023

5. Table S4 from The Tumor Immune Microenvironment Drives a Prognostic Relevance That Correlates with Bladder Cancer Subtypes

Author

Markus Eckstein, Reiner Strick, Arndt Hartmann, Philipp Erben, Franziska Erlmeier, Bastian Keck, Simone Bertz, Robert Stoehr, Veronika Weyerer, Carol I. Geppert, Nicole Fuhrich, Christian Bolenz, Bernd Wullich, Maximilian Burger, Thomas Worst, Wolfgang Otto, Johannes Breyer, Helge Taubert, Adrian Wullweber, Ralph M. Wirtz, Sven Wach, Danijel Sikic, Katherine B. Chiappinelli, Pamela L. Strissel, and Carolin Pfannstiel

Abstract

Inflammation gene signature TCGA: Full table of included genes.

Published
2023

6. Table S7 from The Tumor Immune Microenvironment Drives a Prognostic Relevance That Correlates with Bladder Cancer Subtypes

Author

Markus Eckstein, Reiner Strick, Arndt Hartmann, Philipp Erben, Franziska Erlmeier, Bastian Keck, Simone Bertz, Robert Stoehr, Veronika Weyerer, Carol I. Geppert, Nicole Fuhrich, Christian Bolenz, Bernd Wullich, Maximilian Burger, Thomas Worst, Wolfgang Otto, Johannes Breyer, Helge Taubert, Adrian Wullweber, Ralph M. Wirtz, Sven Wach, Danijel Sikic, Katherine B. Chiappinelli, Pamela L. Strissel, and Carolin Pfannstiel

Abstract

Antigen presenting cell signature TCGA: Full table of included genes.

Published
2023

7. Table S6 from The Tumor Immune Microenvironment Drives a Prognostic Relevance That Correlates with Bladder Cancer Subtypes

Author

Markus Eckstein, Reiner Strick, Arndt Hartmann, Philipp Erben, Franziska Erlmeier, Bastian Keck, Simone Bertz, Robert Stoehr, Veronika Weyerer, Carol I. Geppert, Nicole Fuhrich, Christian Bolenz, Bernd Wullich, Maximilian Burger, Thomas Worst, Wolfgang Otto, Johannes Breyer, Helge Taubert, Adrian Wullweber, Ralph M. Wirtz, Sven Wach, Danijel Sikic, Katherine B. Chiappinelli, Pamela L. Strissel, and Carolin Pfannstiel

Abstract

Multivariable Survival Models.

Published
2023

8. Table S2 from The Tumor Immune Microenvironment Drives a Prognostic Relevance That Correlates with Bladder Cancer Subtypes

Author

Markus Eckstein, Reiner Strick, Arndt Hartmann, Philipp Erben, Franziska Erlmeier, Bastian Keck, Simone Bertz, Robert Stoehr, Veronika Weyerer, Carol I. Geppert, Nicole Fuhrich, Christian Bolenz, Bernd Wullich, Maximilian Burger, Thomas Worst, Wolfgang Otto, Johannes Breyer, Helge Taubert, Adrian Wullweber, Ralph M. Wirtz, Sven Wach, Danijel Sikic, Katherine B. Chiappinelli, Pamela L. Strissel, and Carolin Pfannstiel

Abstract

Reference Sequences - Nanostring analysis for subtyping (CCC-EMN cohort).

Published
2023

9. Tumor-derived exosomes modulate PD-L1 expression in monocytes

Author

Stephan Stilgenbauer, Sven Diederichs, Marc Zapatka, Angela Schulz, Peter Lichter, Jérôme Paggetti, Maria Göbel, Laura Llao Cid, Karolin V. Willmund, Axel Benner, Uwe Warnken, Thomas Worst, Murat Iskar, Jana Seiler, Martina Seiffert, Ralph Schulz, Jan Dürig, Etienne Moussay, Franziska Haderk, Thorsten Zenz, and Michelle Nessling

Subjects
0301 basic medicine, Chemokine, biology, Immunology, Medizin, RNA, CCL4, Inflammation, General Medicine, TLR7, CCL2, Microvesicles, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, hemic and lymphatic diseases, 030220 oncology & carcinogenesis, biology.protein, medicine, Cancer research, medicine.symptom, Receptor
Abstract

In chronic lymphocytic leukemia (CLL), monocytes and macrophages are skewed toward protumorigenic phenotypes, including the release of tumor-supportive cytokines and the expression of immunosuppressive molecules such as programmed cell death 1 ligand 1 (PD-L1). To understand the mechanism driving protumorigenic skewing in CLL, we evaluated the role of tumor cell-derived exosomes in the cross-talk with monocytes. We carried out RNA sequencing and proteome analyses of CLL-derived exosomes and identified noncoding Y RNA hY4 as a highly abundant RNA species that is enriched in exosomes from plasma of CLL patients compared with healthy donor samples. Transfer of CLL-derived exosomes or hY4 alone to monocytes resulted in key CLL-associated phenotypes, including the release of cytokines, such as C-C motif chemokine ligand 2 (CCL2), CCL4, and interleukin-6, and the expression of PD-L1. These responses were abolished in Toll-like receptor 7 (TLR7)-deficient monocytes, suggesting exosomal hY4 as a driver of TLR7 signaling. Pharmacologic inhibition of endosomal TLR signaling resulted in a substantially reduced activation of monocytes in vitro and attenuated CLL development in vivo. Our results indicate that exosome-mediated transfer of noncoding RNAs to monocytes contributes to cancer-related inflammation and concurrent immune escape via PD-L1 expression.

Published
2016

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