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2. 'I Couldn’t See a Downside': Decision-Making About Gender-Affirming Hormone Therapy

Author

Thomas Daley, Daniel H. Grossoehme, Sarah D. Corathers, Lee Ann E. Conard, Jenifer K. McGuire, and Ellen A. Lipstein

Subjects
Adult, Male, Parents, Gender dysphoria, Adolescent, Health Personnel, media_common.quotation_subject, Decision Making, MEDLINE, Psychological intervention, Transgender Persons, Developmental psychology, Interviews as Topic, Transgender, medicine, Humans, Testosterone, Gender Dysphoria, Qualitative Research, media_common, Public Health, Environmental and Occupational Health, medicine.disease, Psychiatry and Mental health, Feeling, Pediatrics, Perinatology and Child Health, Happiness, Female, Thematic analysis, Psychology, Gonadal Hormones, Qualitative research
Abstract

Purpose The aim of the article was to understand adolescents' and parents' decision-making process related to gender-affirming hormone therapy (GAHT). Methods We conducted qualitative semistructured interviews with transgender adolescents who began testosterone for GAHT in the prior year and the parents of such adolescents. Questions focused on decision-making roles, steps in the decision process, and factors considered in the decision. Participants used pie charts to describe the division of responsibility for the decision. All interviews were coded by at least two members of the research team with disagreements resolved through discussion. Thematic analysis was used to analyze the data. Results Seventeen adolescents and 13 parents were interviewed (12 dyads). The process of deciding about GAHT involves a series of small conversations, typically with the adolescent advocating to start treatment and the parent feeling hesitant. In most cases, after seeking information from the Internet, healthcare providers and personal contacts move toward acceptance and agree to start treatment. Although adolescents have some short-term concerns, such as about needles, parents’ concerns relate more to long-term risks. Ultimately, for both parents and adolescents, the benefits of treatment outweigh any concerns, and they are in agreement about the goals of personal confidence, comfort in one's body and happiness. Conclusions To the extent that the decision about GAHT is a medical decision, the decision process is similar to others. However, decisions about GAHT are much more about gender identity than medical risks, suggesting that interventions based in a medical framework may not aid in supporting decision-making.

Published
2019

6. Abstract 1550: FT576 path to first-of-kind clinical trial: translation of a versatile multi-antigen specific off-the-shelf NK cell for treatment of multiple myeloma

Author

Jode P Goodridge, Yu-Waye Chu, Sajid Mahmood, Miguel Meza, Svetlana Gaidarova, Robert Blum, Thomas H. Lee, Jeffrey S. Miller, Brian Groff, Bruce Walcheck, Bahram Valamehr, Frank Cichocki, John Reiser, Greg Bonello, Thomas Daley, Hui-yi Chu, Karl-Johan Malmberg, Ryan Bjordahl, and Armin Rehm

Subjects
Cancer Research, Computer science, Cell, Translation (biology), Computational biology, medicine.disease, Clinical trial, medicine.anatomical_structure, Oncology, Antigen specific, Path (graph theory), medicine, Off the shelf, Multiple myeloma
Abstract

Chimeric antigen receptor (CAR) directed therapies have been used successfully to treat a variety of hematological malignancies. With the advent of multi-modal engineering, adoptive cell therapy offers the opportunity to tackle increasingly complex disease settings such as multiple myeloma (MM), where targeting of single tumor associated antigen by CAR or monoclonal antibodies (mAb) is confounded by antigen loss and clonal heterogeneity. Further, expanding treatment options beyond primary T and NK cell based therapies has multiple advantages, including the use of induced pluripotent stem cells (iPSC) to derive effector cells using precision genetic engineering that can be uniformly manufactured at scale from a clonally-derived master cell bank (MCB).FT576 is a multiplex-edited, iPSC-derived CAR-NK (CAR-iNK) cell therapy designed for treatment of Multiple Myeloma. FT576 is engineered 1) to express a recombinant IL-15/IL-15 receptor signaling complex (IL-15RF) for enhanced persistence; 2) to express an enhanced high-affinity, non-cleavable CD16 (hnCD16) ; 3) to disrupt expression of CD38, allowing for enhanced ADCC without NK cell fratricide; and 4) to express a BCMA-targeted CAR with NK-cell optimized signaling.CAR-directed specificity of the FT576 cells for BCMA was demonstrated using a short-term cytotoxicity assay (90.8% cytotoxicity against BCMA+ vs 22.1% BCMA- cells, p Citation Format: Jode P. Goodridge, Ryan Bjordahl, Sajid Mahmood, John Reiser, Svetlana Gaidarova, Robert Blum, Frank Cichocki, Hui-yi Chu, Greg Bonello, Tom Lee, Brian Groff, Miguel Meza, Thomas Daley, Yu-waye Chu, Bruce Walcheck, Karl-Johan Malmberg, Jeffrey S. Miller, Armin Rehm, Bahram Valamehr. FT576 path to first-of-kind clinical trial: translation of a versatile multi-antigen specific off-the-shelf NK cell for treatment of multiple myeloma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2021; 2021 Apr 10-15 and May 17-21. Philadelphia (PA): AACR; Cancer Res 2021;81(13_Suppl):Abstract nr 1550.

Published
2021

7. Monitoring the process of formation of ZnO from ZnO2 using in situ combined XRD/XAS technique

Author

Kwasi B Opuni, Andrew J. Dent, Edwin Raj, Timothy I. Hyde, Gopinathan Sankar, Giannantonio Cibin, and Thomas Daley

Subjects
X-ray absorption spectroscopy, Thermogravimetric analysis, Materials science, Absorption spectroscopy, Thermal decomposition, Analytical chemistry, chemistry.chemical_element, Zinc, Atmospheric temperature range, Condensed Matter Physics, XANES, chemistry.chemical_compound, chemistry, General Materials Science, Zinc peroxide
Abstract

Use of in situ combined x-ray diffraction and x-ray absorption spectroscopy for the study of the thermal decomposition of zinc peroxide to zinc oxide is reported here. Comparison of data extracted from both x-ray diffraction (XRD) and x-ray absorption spectroscopy (XAS) with thermo gravimetric analysis (TGA) enabled us to follow the nature of the conversion of ZnO2 to ZnO. A temperature range between 230 °C and 350 °C appears to show that a very poorly crystalline ZnO is formed prior to the formation of an ordered ZnO material. Both the decrease in white line intensity in the Zn K-edge XANES and resulting lower coordination numbers estimated from analysis of the Zn K-edge data of ZnO heated at 500 °C, in comparison to bulk ZnO, suggest that the ZnO produced by this method has significant defects in the system.

Published
2021

8. SAGEEP 2017 papers with only a paragraph abstract

Author

Christopher Arp, Frank Jalinoos, Sarah Moriarty, Esben Auken, Jordan K. Harding, Douglas LaBrecque, Robin Glas, Ryan North, Aaron Davis, Laura Sherrod, Bitnarae Kim, Garth Richards, Frederick Day-Lewis, Daniel LaBrecque, Qian Yin, Thomas Mejer Hansen, Jason Payne, Jeanne LeFebvre, Richard Krahenbuhl, Isaac Fage, Adnan Aydin, Robin Dornfest, Carl-Axel Triumf, Nobuhito Nagai, Myles Danforth, Paul Bedrosian, Sue Natali, Alain Plattner, Moones Alamooti, Hongchun Yao, Nicholas Sowko, Marvin Speece, Carole D. Johnson, Shane Mulè, Jill Densmore, Daniel Richter, Austin Keller, Nathan Davis, Allen Bondurant, William Doll, Jean M. Legault, Austin Carey, Vivek Anand, Koichi Hayashi, Judy Robinson, Paul Nelson, Edward Muller, Elchin Jafarov, Brian Ham, Kira Dickey, Isabelle Cozzarelli, Kivanc Sabunis, Shishay Kidanu, Trevor Irons, Aaron Cahill, Jared D. Abraham, Nathan Smith, Philip Reeder, Roger Michaelides, Chih-Ping Lin, Tim Sickbert, Forrest Kunkel, Mohamed G. Abdelsalam, Andrew D. Parsekian, Katherine Grote, Mark Oliver, Shaoqin Sun, Kit Miyamoto, Eiichi Fukushima, Shaul Hurwitz, Shan Dou, Jason Cox, Brady Flinchum, Kevin Bjella, Terrance Delisser, Roy Bowling, Adam Ward, David Beckendorff, David Palandro, Nikolas Gazo, Jan Francke, Upasna Chandarana, Bojan Milinic, Yin Jeh Ngui, Anders Lund, Paul O'Neill, Payman Hajiani, Sean Wagner, Torleif Dahlin, Phil Sirles, Timothy Munday, Colby Steelman, Lena Persson, Justin Kulongoski, Robert R. Stewart, Geoff Pettifer, Graham Jenke, Mats Lundh Gulbrandsen, Leanne Hanson, Doug Laymon, Chun-Hung Lin, Robert Thompson, Dave Walsh, Matthew Struckhoff, David O. Walsh, Akpofure Orubu, Mike Müller-Petke, Geoffrey Plastow, Anna Wagner, John Cherry, Emine Avci, Ryan Harmon, Peter Dahlqvist, Dung Nguyen, Martial Morrison, Annette Hein, Barbara Bekins, Somaria Sammy, Dylan Rose-Coss, Kevin Schaefer, Myung Jin Nam, Hannuree Jang, Yang Lei, Xuefeng Zhao, Toni Ivey, Jay Silverstein, Thomas McKenna, Sarah L. Codd, Jalf Salima, Timothy Nedwed, John H. Bradford, Ryan Brumbaugh, Melvyn Best, Nathan Campbell, Donovan Capes, Ahmed Ismail, Sarah Ludwig, Maneh Kotikian, Chad Cote, Fethi Ahmet Yuksel, Steven Jepsen, Jakob Juul Larsen, Hangilro Jang, Cullen Pickens, Mark Seyfried, Andrew Black, Elizabeth Screaton, Timothy deSmet, Richard Smith, Burke J. Minsley, Jonathan E. Nyquist, Rujun Chen, Paul Bauman, Barry Freifeld, Leonard Kalindekafe, Dale F. Rucker, David Smith, Juan Carlos Laya, Brian Bird, Sevket Donmez, Esther Babcock, Jackie Randell, E. Michael Chapa, Daphne Szutu, Neil Anderson, John W. Lane, Mark Hudson, Kelly Devlin, Eileen Martin, Marios Karaoulis, Jeffrey Paine, Jeffrey Munsey, Nigel Crook, Stephen Altobelli, Micah Mayle, Camilla Soerensen, Kevin Mitchell, Pauline Kessouri, Benjamin Jones, Mohamed Khalil, Elliot Grunewald, Scott Ikard, Dominic Monarco, Juan Lorenzo, Bruce Wylie, Ross Groom, Mark Panning, Jon Seligman, Gary Robbins, Robert Crowder, Dylan Klazinga, Tony Endres, Khori Newlander, Stefan Kropidlowski, Raphael Dlugosch, Clifford Voss, Folarin Kolawole, Pavel Tishin, M. Andy Kass, Dario Grana, Robert Moucha, Isaac Stephens, Holly Barnard, Mahmut Ziya Gorucu, Mark Conradi, Niels Claes, Craig J. Hickey, David Miller, Kevin Hon, Kathryn Decker, Arthur Gelvin, Jeffrey Cook, Jeffrey McKenzie, Brian Cubbage, Beth Parker, Yukio Tobe, Brian McPherson, Estella A. Atekwana, Ashley Richardson, Christopher Buckman, Rongyi Qian, Andrew Teeple, Bryant Robbins, Khamis Haramy, Neil Lester, Dimitrios Ntarlagiannis, Nathaniel Lindsey, Ken Sims, Bradley J. Carr, Jim Pfeiffer, Flemming Jørgensen, Laura Toran, Andrea Creighton, Jennifer Rover, Adrienne J. Phillips, Rebecca Travis, Richard Freund, Jesper Pedersen, Afshin Aghayan, Seo Young Song, Alexander Prikhodko, James Oliver, Evgeniy Torgashov, Len Mankowski, Matthew Wise, Kristina Keating, Kathleen Cameron, Russell Brigham, Mark Everett, Neal J. Pastick, Jeffrey R. Kennedy, Seiichiro Kuroda, Gail Heath, Marco de Kleine, Ginger B. Paige, Martin A. Briggs, Ryan Banta, Lin Liu, Hirotaka Saito, Jacob Sheehan, Raymond Russo, Theis Raaschou Andersen, Austin Robbins, Sean Schaefer, Lyndsay Ball, Nicholas Zaremba, Gregory Stanton, John Mundell, Catherine M. Kirkland, Victor Nyalugwe, Stephanie James, Carol Finn, Ruijie Shen, Bryan Mark, Andrew Fletcher, Mitchell Craig, Kerim Avci, James C. Cannia, Josip Adams, A.C. Chen, W. Steven Holbrook, Daniel Laó-Dávila, Hans Thomann, Geoffrey Cromwell, Zhiyuan An, William Sauck, Theodore H. Asch, Adam Smiarowski, Santosh Panda, Braden Hrencher, Peeter Pehme, Hsing-Chang Liu, David Hallman, Lee Slater, Michelle Walvoord, Mario Carnevale, Ric Federico, Sean Hussey, William Ampomah, Thomas Daley, Celia Kennedy, Mike Culig, Stuart Norton, Jeannot Ngalamo, David Buesch, Christian Aneke, Timothy Eadie, Erika Beam, Moe Momayez, Jonathan Ajo-Franklin, Thomas Guenther, Bill Brown, Alastair McClymont, Denys Grombacher, Kamini Singha, Tom Martlev Pallesen, Gianfranco Morelli, Ian Ekblaw, Yaoguo Li, Travis Nielson, Mohammad Mohammadi, Torben Bach, Christopher Holmquist-Johnson, Arnd Obert, Andres Kozlowski, Rikke Jacobsen, Patrick Chindandali, Edward Collins, Giulio Vignoli, Shawn Ryan, Jacob Lowenstern, Stephanie Phillips, Craig Ulrich, Jodie Mead, Laura Lautz, Haroon Tayyab, Charles Stanford, Kevin Parkman, Diego Domenzain, David Vales, Michael N. Gooseff, Christopher W. Smith, Ye Zhang, Toshiki Iwasaki, Lewis Land, Harry Jol, Michael Kalinski, and Jason Heath

Subjects
Philosophy, Paragraph, Linguistics
Published
2017

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