1. Regional mechanical dyssynchrony and shortened systole are present in people with Takotsubo syndrome
- Author
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Jan-Christian Reil, Vasco Sequeira, Gert-Hinrich Reil, Paul Steendijk, Christoph Maack, Thomas Fink, Elias Rawish, Ingo Eitel, and Thomas Stiermaier
- Subjects
Medicine - Abstract
Abstract Background: Takotsubo syndrome is characterized by transient regional systolic dysfunction, left ventricular (LV) dilatation, and edema, often occurring without obstructive coronary artery disease. The mechanisms underlying this stress-induced condition, especially the role of mechanical dyssynchrony in affecting systolic function, remain poorly understood. Methods: In our study, we evaluated global LV function and mechanical dyssynchrony in 24 Takotsubo patients compared to 20 controls by analyzing pressure-volume loops and time-varying elastance. Additionally, we monitored changes in LV segmental volume and internal flow. Results: Here we show a significant reduction in global myocardial contractility and pronounced mechanical dyssynchrony in Takotsubo syndrome, particularly in the mid and apical LV segments, without disturbances in electrical conduction. Conclusions: Our findings reveal substantial mechanical dyssynchrony in Takotsubo patients, characterized by increased internal flow and a shortened systolic ejection time. This indicates a mechanical basis for the inefficient LV function in Takotsubo syndrome, independent of electrical conduction abnormalities.
- Published
- 2024
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