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1. Fostering eABCD: Asset-Based Community Development in Digital Service-Learning

Author

Shah, Rachael W., Troester, Jennifer Selting, Brooke, Robert, Gatti, Lauren, Thomas, Sarah L., and Masterson, Jessica

Abstract

The continuing expansion of digital service-learning is bringing emergent dynamics to the field of community engagement, including the challenge of fostering asset-based views of community partners in online spaces. "Online disinhibition" ("Suler," 2004) can prompt harsh critique or insensitive language that would not have occurred during face-to-face relationships. Traditionally, the field of community engagement has drawn on asset-based community development ("Kretzmann & McKnight," 1993), which calls for relationship-driven, asset-based, and internally focused partnerships, to encourage ethical and positive interactions with community members. However, this theory was not originally intended for digital, text-based interactions. This article explores how aspects of asset-based community development might be enacted in online partnerships, in electronic asset-based community development (eABCD). A case study of a digital writing partnership between college students and rural youth is used to illustrate how students can be supported in asset-based, relationship-driven, and internally focused interactions in online service-learning collaborations.

Published
2018

2. Response Time Based Nonparametric Kullback-Leibler Divergence Measure for Detecting Aberrant Test-Taking Behavior

Author

Man, Kaiwen, Harring, Jeffery R., Ouyang, Yunbo, and Thomas, Sarah L.

Abstract

Many important high-stakes decisions--college admission, academic performance evaluation, and even job promotion--depend on accurate and reliable scores from valid large-scale assessments. However, examinees sometimes cheat by copying answers from other test-takers or practicing with test items ahead of time, which can undermine the effectiveness of such assessments in yielding accurate, precise information of examinees' performances. This study focuses on the utility of a new nonparametric person-fit index using examinees' response times to detect two types of cheating behaviors. The feasibility of this method was investigated vis-à-vis a Monte Carlo simulation as well as through analyzing data from a large-scale assessment. Findings indicate that the proposed index was quite successful in detecting pre-knowledge cheating and extreme one-item cheating.

Published
2018
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5. Large volume paracentesis of 39.5 liters chylous ascites in the setting of high-grade follicular lymphoma

Author

Hughes, Joseph A., Bishop, Thomas H., McLoney, Eric D., Thomas, Sarah L., Wessinger, John M., Hughes, Joseph A., Bishop, Thomas H., McLoney, Eric D., Thomas, Sarah L., and Wessinger, John M.

Abstract

The American Association for the Study of Liver Diseases recognizes large volume paracentesis as draining greater than 5 liters of ascites and states there is no limit in the amount of ascites drained with appropriate replacement of albumin. For many practitioners performing safe large volume paracentesis between 5 and 10 liters or even 20 liters is not an uncommon practice. However, drainage of higher volumes outside common practice may raise concerns of patient intolerance and complication. The largest volume paracentesis reported in the literature to date is 41 liters. However, few other reports approach this volume. This case report demonstrates patient tolerance of a 39.5-liter paracentesis performed with close monitoring and hypertonic albumin replacement in a patient with chylous ascites due to high-grade follicular lymphoma.

Published
2022

17. Assessment of Effectiveness of Seasonal Influenza Vaccination During Pregnancy in Preventing Influenza Infection in Infants in England, 2013-2014 and 2014-2015.

Author

Walker, Jemma L, Zhao, Hongxin, Dabrera, Gavin, Andrews, Nick, Thomas, Sarah L, Tsang, Camille, Ellis, Joanna, Donati, Matthew, and Pebody, Richard G

Subjects
FLU vaccine efficacy, INFLUENZA, INFANTS, VACCINE effectiveness, INFLUENZA vaccines, INFLUENZA prevention, PREVENTION of communicable diseases, RESEARCH, IMMUNIZATION, COMMUNICABLE diseases, RESEARCH methodology, EVALUATION research, MEDICAL cooperation, COMPARATIVE studies, PREGNANCY complications, RESEARCH funding, INFLUENZA A virus, H3N2 subtype, INFLUENZA A virus, H1N1 subtype, VERTICAL transmission (Communicable diseases)
Abstract

Maternal influenza vaccination is increasingly recognized to protect infants from influenza infection in their first 6 months. We used the screening method to estimate vaccine effectiveness (VE) against laboratory-confirmed influenza in infants in England, using newly available uptake data from the Clinical Practice Research Datalink pregnancy register, matched on week of birth and region and adjusted for ethnicity. We found VE of 66% (95% confidence interval [CI], 18%-84%) in the 2013-2014 season and 50% (95% CI, 11%-72%) in 2014-2015, with similar VE against influenza-related hospitalization. VE against the dominant circulating influenza strain was higher, at 78% (95% CI, 16%-94%) against H1N1 in 2013-2014, and 60% (95% CI, 16%-81%) against H3N2 in 2014-2015. [ABSTRACT FROM AUTHOR]

Published
2020
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19. Estimating the reproducibility of psychological science

Author

Anderson, Joanna E., Aarts, Alexander A., Anderson, Christopher J., Attridge, Peter R., Attwood, Angela, Axt, Jordan, Babel, Molly, Bahník, Štěpán, Baranski, Erica, Barnett-Cowan, Michael, Bartmess, Elizabeth, Beer, Jennifer, Bell, Raoul, Bentley, Heather, Beyan, Leah, Binion, Grace, Borsboom, Denny, Bosch, Annick, Bosco, Frank A., Bowman, Sara D., Brandt, Mark J., Braswell, Erin, Brohmer, Hilmar, Brown, Benjamin T., Brown, Kristina, Brüning, Jovita, Calhoun-Sauls, Ann, Callahan, Shannon P., Chagnon, Elizabeth, Chandler, Jesse, Chartier, Christopher R., Cheung, Felix, Christopherson, Cody D., Cillessen, Linda, Clay, Russ, Cleary, Hayley, Cloud, Mark D., Conn, Michael, Cohoon, Johanna, Columbus, Simon, Cordes, Andreas, Costantini, Giulio, Alvarez, Leslie D Cramblet, Cremata, Ed, Crusius, Jan, DeCoster, Jamie, DeGaetano, Michelle A., Penna, Nicolás Delia, Den Bezemer, Bobby, Deserno, Marie K., Devitt, Olivia, Dewitte, Laura, Dobolyi, David G., Dodson, Geneva T., Donnellan, M. Brent, Donohue, Ryan, Dore, Rebecca A., Dorrough, Angela, Dreber, Anna, Dugas, Michelle, Dunn, Elizabeth W., Easey, Kayleigh, Eboigbe, Sylvia, Eggleston, Casey, Embley, Jo, Epskamp, Sacha, Errington, Timothy M., Estel, Vivien, Farach, Frank J., Feather, Jenelle, Fedor, Anna, Fernández-Castilla, Belén, Fiedler, Susann, Field, James G., Fitneva, Stanka A., Flagan, Taru, Forest, Amanda L., Forsell, Eskil, Foster, Joshua D., Frank, Michael C., Frazier, Rebecca S., Fuchs, Heather, Gable, Philip, Galak, Jeff, Galliani, Elisa Maria, Gampa, Anup, Garcia, Sara, Gazarian, Douglas, Gilbert, Elizabeth, Giner-Sorolla, Roger, Glöckner, Andreas, Goellner, Lars, Goh, Jin X., Goldberg, Rebecca, Goodbourn, Patrick T., Gordon-McKeon, Shauna, Gorges, Bryan, Gorges, Jessie, Goss, Justin, Graham, Jesse, Grange, James A., Gray, Jeremy, Hartgerink, Chris, Hartshorne, Joshua, Hasselman, Fred, Hayes, Timothy, Heikensten, Emma, Henninger, Felix, Hodsoll, John, Holubar, Taylor, Hoogendoorn, Gea, Humphries, Denise J., Hung, Cathy O Y, Immelman, Nathali, Irsik, Vanessa C., Jahn, Georg, Jäkel, Frank, Jekel, Marc, Johannesson, Magnus, Johnson, Larissa G., Johnson, David J., Johnson, Kate M., Johnston, William J., Jonas, Kai, Joy-Gaba, Jennifer A., Kappes, Heather Barry, Kelso, Kim, Kidwell, Mallory C., Kim, Seung Kyung, Kirkhart, Matthew, Kleinberg, Bennett, Knežević, Goran, Kolorz, Franziska Maria, Kossakowski, Jolanda J., Krause, Robert Wilhelm, Krijnen, Job, Kuhlmann, Tim, Kunkels, Yoram K., Kyc, Megan M., Lai, Calvin K., Laique, Aamir, Lakens, Daniël, Lane, Kristin A., Lassetter, Bethany, Lazarević, Ljiljana B., Le Bel, Etienne P., Lee, Key Jung, Lee, Minha, Lemm, Kristi, Levitan, Carmel A., Lewis, Melissa, Lin, Lin, Lin, Stephanie, Lippold, Matthias, Loureiro, Darren, Luteijn, Ilse, MacKinnon, Sean, Mainard, Heather N., Marigold, Denise C., Martin, Daniel P., Martinez, Tylar, Masicampo, E. J., Matacotta, Josh, Mathur, Maya, May, Michael, Mechin, Nicole, Mehta, Pranjal, Meixner, Johannes, Melinger, Alissa, Miller, Jeremy K., Miller, Mallorie, Moore, Katherine, Möschl, Marcus, Motyl, Matt, Müller, Stephanie M., Munafo, Marcus, Neijenhuijs, Koen I., Nervi, Taylor, Nicolas, Gandalf, Nilsonne, Gustav, Nosek, Brian A., Nuijten, Michèle B., Olsson, Catherine, Osborne, Colleen, Ostkamp, Lutz, Pavel, Misha, Penton-Voak, Ian S., Perna, Olivia, Pernet, Cyril, Perugini, Marco, Pipitone, R. Nathan, Pitts, Michael, Plessow, Franziska, Prenoveau, Jason M., Rahal, Rima Maria, Ratliff, Kate A., Reinhard, David, Renkewitz, Frank, Ricker, Ashley A., Rigney, Anastasia, Rivers, Andrew M., Roebke, Mark, Rutchick, Abraham M., Ryan, Robert S., Sahin, Onur, Saide, Anondah, Sandstrom, Gillian M., Santos, David, Saxe, Rebecca, Schlegelmilch, René, Schmidt, Kathleen, Scholz, Sabine, Seibel, Larissa, Selterman, Dylan Faulkner, Shaki, Samuel, Simpson, William B., Sinclair, H. Colleen, Skorinko, Jeanine L M, Slowik, Agnieszka, Snyder, Joel S., Soderberg, Courtney, Sonnleitner, Carina, Spencer, Nick, Spies, Jeffrey R., Steegen, Sara, Stieger, Stefan, Strohminger, Nina, Sullivan, Gavin B., Talhelm, Thomas, Tapia, Megan, Te Dorsthorst, Anniek, Thomae, Manuela, Thomas, Sarah L., Tio, Pia, Traets, Frits, Tsang, Steve, Tuerlinckx, Francis, Turchan, Paul, Valášek, Milan, Van't Veer, Anna E., Van Aert, Robbie, Van Assen, Marcel, Van Bork, Riet, Van De Ven, Mathijs, Van Den Bergh, Don, Van Der Hulst, Marije, Van Dooren, Roel, Van Doorn, Johnny, Van Renswoude, Daan R., Van Rijn, Hedderik, Vanpaemel, Wolf, Echeverría, Alejandro Vásquez, Vazquez, Melissa, Velez, Natalia, Vermue, Marieke, Verschoor, Mark, Vianello, Michelangelo, Voracek, Martin, Vuu, Gina, Wagenmakers, Eric Jan, Weerdmeester, Joanneke, Welsh, Ashlee, Westgate, Erin C., Wissink, Joeri, Wood, Michael, Woods, Andy, Wright, Emily, Wu, Sining, Zeelenberg, Marcel, Zuni, Kellylynn, Anderson, Joanna E., Aarts, Alexander A., Anderson, Christopher J., Attridge, Peter R., Attwood, Angela, Axt, Jordan, Babel, Molly, Bahník, Štěpán, Baranski, Erica, Barnett-Cowan, Michael, Bartmess, Elizabeth, Beer, Jennifer, Bell, Raoul, Bentley, Heather, Beyan, Leah, Binion, Grace, Borsboom, Denny, Bosch, Annick, Bosco, Frank A., Bowman, Sara D., Brandt, Mark J., Braswell, Erin, Brohmer, Hilmar, Brown, Benjamin T., Brown, Kristina, Brüning, Jovita, Calhoun-Sauls, Ann, Callahan, Shannon P., Chagnon, Elizabeth, Chandler, Jesse, Chartier, Christopher R., Cheung, Felix, Christopherson, Cody D., Cillessen, Linda, Clay, Russ, Cleary, Hayley, Cloud, Mark D., Conn, Michael, Cohoon, Johanna, Columbus, Simon, Cordes, Andreas, Costantini, Giulio, Alvarez, Leslie D Cramblet, Cremata, Ed, Crusius, Jan, DeCoster, Jamie, DeGaetano, Michelle A., Penna, Nicolás Delia, Den Bezemer, Bobby, Deserno, Marie K., Devitt, Olivia, Dewitte, Laura, Dobolyi, David G., Dodson, Geneva T., Donnellan, M. Brent, Donohue, Ryan, Dore, Rebecca A., Dorrough, Angela, Dreber, Anna, Dugas, Michelle, Dunn, Elizabeth W., Easey, Kayleigh, Eboigbe, Sylvia, Eggleston, Casey, Embley, Jo, Epskamp, Sacha, Errington, Timothy M., Estel, Vivien, Farach, Frank J., Feather, Jenelle, Fedor, Anna, Fernández-Castilla, Belén, Fiedler, Susann, Field, James G., Fitneva, Stanka A., Flagan, Taru, Forest, Amanda L., Forsell, Eskil, Foster, Joshua D., Frank, Michael C., Frazier, Rebecca S., Fuchs, Heather, Gable, Philip, Galak, Jeff, Galliani, Elisa Maria, Gampa, Anup, Garcia, Sara, Gazarian, Douglas, Gilbert, Elizabeth, Giner-Sorolla, Roger, Glöckner, Andreas, Goellner, Lars, Goh, Jin X., Goldberg, Rebecca, Goodbourn, Patrick T., Gordon-McKeon, Shauna, Gorges, Bryan, Gorges, Jessie, Goss, Justin, Graham, Jesse, Grange, James A., Gray, Jeremy, Hartgerink, Chris, Hartshorne, Joshua, Hasselman, Fred, Hayes, Timothy, Heikensten, Emma, Henninger, Felix, Hodsoll, John, Holubar, Taylor, Hoogendoorn, Gea, Humphries, Denise J., Hung, Cathy O Y, Immelman, Nathali, Irsik, Vanessa C., Jahn, Georg, Jäkel, Frank, Jekel, Marc, Johannesson, Magnus, Johnson, Larissa G., Johnson, David J., Johnson, Kate M., Johnston, William J., Jonas, Kai, Joy-Gaba, Jennifer A., Kappes, Heather Barry, Kelso, Kim, Kidwell, Mallory C., Kim, Seung Kyung, Kirkhart, Matthew, Kleinberg, Bennett, Knežević, Goran, Kolorz, Franziska Maria, Kossakowski, Jolanda J., Krause, Robert Wilhelm, Krijnen, Job, Kuhlmann, Tim, Kunkels, Yoram K., Kyc, Megan M., Lai, Calvin K., Laique, Aamir, Lakens, Daniël, Lane, Kristin A., Lassetter, Bethany, Lazarević, Ljiljana B., Le Bel, Etienne P., Lee, Key Jung, Lee, Minha, Lemm, Kristi, Levitan, Carmel A., Lewis, Melissa, Lin, Lin, Lin, Stephanie, Lippold, Matthias, Loureiro, Darren, Luteijn, Ilse, MacKinnon, Sean, Mainard, Heather N., Marigold, Denise C., Martin, Daniel P., Martinez, Tylar, Masicampo, E. J., Matacotta, Josh, Mathur, Maya, May, Michael, Mechin, Nicole, Mehta, Pranjal, Meixner, Johannes, Melinger, Alissa, Miller, Jeremy K., Miller, Mallorie, Moore, Katherine, Möschl, Marcus, Motyl, Matt, Müller, Stephanie M., Munafo, Marcus, Neijenhuijs, Koen I., Nervi, Taylor, Nicolas, Gandalf, Nilsonne, Gustav, Nosek, Brian A., Nuijten, Michèle B., Olsson, Catherine, Osborne, Colleen, Ostkamp, Lutz, Pavel, Misha, Penton-Voak, Ian S., Perna, Olivia, Pernet, Cyril, Perugini, Marco, Pipitone, R. Nathan, Pitts, Michael, Plessow, Franziska, Prenoveau, Jason M., Rahal, Rima Maria, Ratliff, Kate A., Reinhard, David, Renkewitz, Frank, Ricker, Ashley A., Rigney, Anastasia, Rivers, Andrew M., Roebke, Mark, Rutchick, Abraham M., Ryan, Robert S., Sahin, Onur, Saide, Anondah, Sandstrom, Gillian M., Santos, David, Saxe, Rebecca, Schlegelmilch, René, Schmidt, Kathleen, Scholz, Sabine, Seibel, Larissa, Selterman, Dylan Faulkner, Shaki, Samuel, Simpson, William B., Sinclair, H. Colleen, Skorinko, Jeanine L M, Slowik, Agnieszka, Snyder, Joel S., Soderberg, Courtney, Sonnleitner, Carina, Spencer, Nick, Spies, Jeffrey R., Steegen, Sara, Stieger, Stefan, Strohminger, Nina, Sullivan, Gavin B., Talhelm, Thomas, Tapia, Megan, Te Dorsthorst, Anniek, Thomae, Manuela, Thomas, Sarah L., Tio, Pia, Traets, Frits, Tsang, Steve, Tuerlinckx, Francis, Turchan, Paul, Valášek, Milan, Van't Veer, Anna E., Van Aert, Robbie, Van Assen, Marcel, Van Bork, Riet, Van De Ven, Mathijs, Van Den Bergh, Don, Van Der Hulst, Marije, Van Dooren, Roel, Van Doorn, Johnny, Van Renswoude, Daan R., Van Rijn, Hedderik, Vanpaemel, Wolf, Echeverría, Alejandro Vásquez, Vazquez, Melissa, Velez, Natalia, Vermue, Marieke, Verschoor, Mark, Vianello, Michelangelo, Voracek, Martin, Vuu, Gina, Wagenmakers, Eric Jan, Weerdmeester, Joanneke, Welsh, Ashlee, Westgate, Erin C., Wissink, Joeri, Wood, Michael, Woods, Andy, Wright, Emily, Wu, Sining, Zeelenberg, Marcel, and Zuni, Kellylynn

Abstract

Reproducibility is a defining feature of science, but the extent to which it characterizes current research is unknown. We conducted replications of 100 experimental and correlational studies published in three psychology journals using high-powered designs and original materials when available. Replication effects were half the magnitude of original effects, representing a substantial decline. Ninety-seven percent of original studies had statistically significant results. Thirty-six percent of replications had statistically significant results; 47% of original effect sizes were in the 95% confidence interval of the replication effect size; 39% of effects were subjectively rated to have replicated the original result; and if no bias in original results is assumed, combining original and replication results left 68% with statistically significant effects. Correlational tests suggest that replication success was better predicted by the strength of original evidence than by characteristics of the original and replication teams.

Published
2015

20. Estimating the reproducibility of psychological science

Author

Aarts, Alexander A., Anderson, Joanna E., Anderson, Christopher J., Attridge, Peter R., Attwood, Angela, Axt, Jordan, Babel, Molly, Bahnik, Stepan, Baranski, Erica, Barnett-Cowan, Michael, Bartmess, Elizabeth, Beer, Jennifer, Bell, Raoul, Bentley, Heather, Beyan, Leah, Binion, Grace, Borsboom, Denny, Bosch, Annick, Bosco, Frank A., Bowman, Sara D., Brandt, Mark J., Braswell, Erin, Brohmer, Hilmar, Brown, Benjamin T., Brown, Kristina, Bruening, Jovita, Calhoun-Sauls, Ann, Callahan, Shannon P., Chagnon, Elizabeth, Chandler, Jesse, Chartier, Christopher R., Cheung, Felix, Christopherson, Cody D., Cillessen, Linda, Clay, Russ, Cleary, Hayley, Cloud, Mark D., Cohn, Michael, Cohoon, Johanna, Columbus, Simon, Cordes, Andreas, Costantini, Giulio, Alvarez, Leslie D. Cramblet, Cremata, Ed, Crusius, Jan, DeCoster, Jamie, DeGaetano, Michelle A., Della Penna, Nicolas, den Bezemer, Bobby, Deserno, Marie K., Devitt, Olivia, Dewitte, Laura, Dobolyi, David G., Dodson, Geneva T., Donnellan, M. Brent, Donohue, Ryan, Dore, Rebecca A., Dorrough, Angela, Dreber, Anna, Dugas, Michelle, Dunn, Elizabeth W., Easey, Kayleigh, Eboigbe, Sylvia, Eggleston, Casey, Embley, Jo, Epskamp, Sacha, Errington, Timothy M., Estel, Vivien, Farach, Frank J., Feather, Jenelle, Fedor, Anna, Fernandez-Castilla, Belen, Fiedler, Susann, Field, James G., Fitneva, Stanka A., Flagan, Taru, Forest, Amanda L., Forsell, Eskil, Foster, Joshua D., Frank, Michael C., Frazier, Rebecca S., Fuchs, Heather, Gable, Philip, Galak, Jeff, Galliani, Elisa Maria, Gampa, Anup, Garcia, Sara, Gazarian, Douglas, Gilbert, Elizabeth, Giner-Sorolla, Roger, Gloeckner, Andreas, Goellner, Lars, Goh, Jin X., Goldberg, Rebecca, Goodbourn, Patrick T., Gordon-McKeon, Shauna, Gorges, Bryan, Gorges, Jessie, Goss, Justin, Graham, Jesse, Grange, James A., Gray, Jeremy, Hartgerink, Chris, Hartshorne, Joshua, Hasselman, Fred, Hayes, Timothy, Heikensten, Emma, Henninger, Felix, Hodsoll, John, Holubar, Taylor, Hoogendoorn, Gea, Humphries, Denise J., Hung, Cathy O. -Y., Immelman, Nathali, Irsik, Vanessa C., Jahn, Georg, Jaekel, Frank, Jekel, Marc, Johannesson, Magnus, Johnson, Larissa G., Johnson, David J., Johnson, Kate M., Johnston, William J., Jonas, Kai, Joy-Gaba, Jennifer, Kappes, Heather Barry, Kelso, Kim, Kidwell, Mallory C., Kim, Seung Kyung, Kirkhart, Matthew, Kleinberg, Bennett, Knežević, Goran, Kolorz, Franziska Maria, Kossakowski, Jolanda J., Krause, Robert Wilhelm, Krijnen, Job, Kuhlmann, Tim, Kunkels, Yoram K., Kyc, Megan M., Lai, Calvin K., Laique, Aamir, Lakens, Daniel, Lane, Kristin A., Lassetter, Bethany, Lazarević, Ljiljana, LeBel, Etienne P., Lee, Key Jung, Lee, Minha, Lemm, Kristi, Levitan, Carmel A., Lewis, Melissa, Lin, Lin, Lin, Stephanie, Lippold, Matthias, Loureiro, Darren, Luteijn, Ilse, Mackinnon, Sean, Mainard, Heather N., Marigold, Denise C., Martin, Daniel P., Martinez, Tylar, Masicampo, E. J., Matacotta, Josh, Mathur, Maya, May, Michael, Mechin, Nicole, Mehta, Pranjal, Meixner, Johannes, Melinger, Alissa, Miller, Jeremy K., Miller, Mallorie, Moore, Katherine, Moeschl, Marcus, Motyl, Matt, Mueller, Stephanie M., Munafo, Marcus, Neijenhuijs, Koen I., Nervi, Taylor, Gandalf, Nicolas, Nilsonne, Gustav, Nosek, Brian A., Nuijten, Michele B., Olsson, Catherine, Osborne, Colleen, Ostkamp, Lutz, Pavel, Misha, Penton-Voak, Ian S., Perna, Olivia, Pernet, Cyril, Perugini, Marco, Pipitone, R. Nathan, Pitts, Michael, Plessow, Franziska, Prenoveau, Jason M., Rahal, Rima-Maria, Ratliff, Kate A., Reinhard, David, Renkewitz, Frank, Ricker, Ashley A., Rigney, Anastasia, Rivers, Andrew M., Roebke, Mark, Rutchick, Abraham M., Ryan, Robert S., Sahin, Onur, Saide, Anondah, Sandstrom, Gillian M., Santos, David, Saxe, Rebecca, Schlegelmilch, Rene, Schmidt, Kathleen, Scholz, Sabine, Seibel, Larissa, Selterman, Dylan Faulkner, Shaki, Samuel, Simpson, William B., Sinclair, H. Colleen, Skorinko, Jeanine L. M., Slowik, Agnieszka, Snyder, Joel S., Soderberg, Courtney, Sonnleitner, Carina, Spencer, Nick, Spies, Jeffrey R., Steegen, Sara, Stieger, Stefan, Strohminger, Nina, Sullivan, Gavin B., Talhelm, Thomas, Tapia, Megan, te Dorsthorst, Anniek, Thomae, Manuela, Thomas, Sarah L., Tio, Pia, Traets, Frits, Tsang, Steve, Tuerlinckx, Francis, Turchan, Paul, Valasek, Milan, van 't Veer, Anna E., Van Aert, Robbie, van Assen, Marcel, van Bork, Riet, van de Ven, Mathijs, van den Bergh, Don, van der Hulst, Marije, van Dooren, Roel, van Doorn, Johnny, van Renswoude, Daan R., van Rijn, Hedderik, Vanpaemel, Wolf, Echeverria, Alejandro Vasquez, Vazquez, Melissa, Velez, Natalia, Vermue, Marieke, Verschoor, Mark, Vianello, Michelangelo, Voracek, Martin, Vuu, Gina, Wagenmakers, Eric-Jan, Weerdmeester, Joanneke, Welsh, Ashlee, Westgate, Erin C., Wissink, Joeri, Wood, Michael, Woods, Andy, Wright, Emily, Wu, Sining, Zeelenberg, Marcel, Zuni, Kellylynn, Aarts, Alexander A., Anderson, Joanna E., Anderson, Christopher J., Attridge, Peter R., Attwood, Angela, Axt, Jordan, Babel, Molly, Bahnik, Stepan, Baranski, Erica, Barnett-Cowan, Michael, Bartmess, Elizabeth, Beer, Jennifer, Bell, Raoul, Bentley, Heather, Beyan, Leah, Binion, Grace, Borsboom, Denny, Bosch, Annick, Bosco, Frank A., Bowman, Sara D., Brandt, Mark J., Braswell, Erin, Brohmer, Hilmar, Brown, Benjamin T., Brown, Kristina, Bruening, Jovita, Calhoun-Sauls, Ann, Callahan, Shannon P., Chagnon, Elizabeth, Chandler, Jesse, Chartier, Christopher R., Cheung, Felix, Christopherson, Cody D., Cillessen, Linda, Clay, Russ, Cleary, Hayley, Cloud, Mark D., Cohn, Michael, Cohoon, Johanna, Columbus, Simon, Cordes, Andreas, Costantini, Giulio, Alvarez, Leslie D. Cramblet, Cremata, Ed, Crusius, Jan, DeCoster, Jamie, DeGaetano, Michelle A., Della Penna, Nicolas, den Bezemer, Bobby, Deserno, Marie K., Devitt, Olivia, Dewitte, Laura, Dobolyi, David G., Dodson, Geneva T., Donnellan, M. Brent, Donohue, Ryan, Dore, Rebecca A., Dorrough, Angela, Dreber, Anna, Dugas, Michelle, Dunn, Elizabeth W., Easey, Kayleigh, Eboigbe, Sylvia, Eggleston, Casey, Embley, Jo, Epskamp, Sacha, Errington, Timothy M., Estel, Vivien, Farach, Frank J., Feather, Jenelle, Fedor, Anna, Fernandez-Castilla, Belen, Fiedler, Susann, Field, James G., Fitneva, Stanka A., Flagan, Taru, Forest, Amanda L., Forsell, Eskil, Foster, Joshua D., Frank, Michael C., Frazier, Rebecca S., Fuchs, Heather, Gable, Philip, Galak, Jeff, Galliani, Elisa Maria, Gampa, Anup, Garcia, Sara, Gazarian, Douglas, Gilbert, Elizabeth, Giner-Sorolla, Roger, Gloeckner, Andreas, Goellner, Lars, Goh, Jin X., Goldberg, Rebecca, Goodbourn, Patrick T., Gordon-McKeon, Shauna, Gorges, Bryan, Gorges, Jessie, Goss, Justin, Graham, Jesse, Grange, James A., Gray, Jeremy, Hartgerink, Chris, Hartshorne, Joshua, Hasselman, Fred, Hayes, Timothy, Heikensten, Emma, Henninger, Felix, Hodsoll, John, Holubar, Taylor, Hoogendoorn, Gea, Humphries, Denise J., Hung, Cathy O. -Y., Immelman, Nathali, Irsik, Vanessa C., Jahn, Georg, Jaekel, Frank, Jekel, Marc, Johannesson, Magnus, Johnson, Larissa G., Johnson, David J., Johnson, Kate M., Johnston, William J., Jonas, Kai, Joy-Gaba, Jennifer, Kappes, Heather Barry, Kelso, Kim, Kidwell, Mallory C., Kim, Seung Kyung, Kirkhart, Matthew, Kleinberg, Bennett, Knežević, Goran, Kolorz, Franziska Maria, Kossakowski, Jolanda J., Krause, Robert Wilhelm, Krijnen, Job, Kuhlmann, Tim, Kunkels, Yoram K., Kyc, Megan M., Lai, Calvin K., Laique, Aamir, Lakens, Daniel, Lane, Kristin A., Lassetter, Bethany, Lazarević, Ljiljana, LeBel, Etienne P., Lee, Key Jung, Lee, Minha, Lemm, Kristi, Levitan, Carmel A., Lewis, Melissa, Lin, Lin, Lin, Stephanie, Lippold, Matthias, Loureiro, Darren, Luteijn, Ilse, Mackinnon, Sean, Mainard, Heather N., Marigold, Denise C., Martin, Daniel P., Martinez, Tylar, Masicampo, E. J., Matacotta, Josh, Mathur, Maya, May, Michael, Mechin, Nicole, Mehta, Pranjal, Meixner, Johannes, Melinger, Alissa, Miller, Jeremy K., Miller, Mallorie, Moore, Katherine, Moeschl, Marcus, Motyl, Matt, Mueller, Stephanie M., Munafo, Marcus, Neijenhuijs, Koen I., Nervi, Taylor, Gandalf, Nicolas, Nilsonne, Gustav, Nosek, Brian A., Nuijten, Michele B., Olsson, Catherine, Osborne, Colleen, Ostkamp, Lutz, Pavel, Misha, Penton-Voak, Ian S., Perna, Olivia, Pernet, Cyril, Perugini, Marco, Pipitone, R. Nathan, Pitts, Michael, Plessow, Franziska, Prenoveau, Jason M., Rahal, Rima-Maria, Ratliff, Kate A., Reinhard, David, Renkewitz, Frank, Ricker, Ashley A., Rigney, Anastasia, Rivers, Andrew M., Roebke, Mark, Rutchick, Abraham M., Ryan, Robert S., Sahin, Onur, Saide, Anondah, Sandstrom, Gillian M., Santos, David, Saxe, Rebecca, Schlegelmilch, Rene, Schmidt, Kathleen, Scholz, Sabine, Seibel, Larissa, Selterman, Dylan Faulkner, Shaki, Samuel, Simpson, William B., Sinclair, H. Colleen, Skorinko, Jeanine L. M., Slowik, Agnieszka, Snyder, Joel S., Soderberg, Courtney, Sonnleitner, Carina, Spencer, Nick, Spies, Jeffrey R., Steegen, Sara, Stieger, Stefan, Strohminger, Nina, Sullivan, Gavin B., Talhelm, Thomas, Tapia, Megan, te Dorsthorst, Anniek, Thomae, Manuela, Thomas, Sarah L., Tio, Pia, Traets, Frits, Tsang, Steve, Tuerlinckx, Francis, Turchan, Paul, Valasek, Milan, van 't Veer, Anna E., Van Aert, Robbie, van Assen, Marcel, van Bork, Riet, van de Ven, Mathijs, van den Bergh, Don, van der Hulst, Marije, van Dooren, Roel, van Doorn, Johnny, van Renswoude, Daan R., van Rijn, Hedderik, Vanpaemel, Wolf, Echeverria, Alejandro Vasquez, Vazquez, Melissa, Velez, Natalia, Vermue, Marieke, Verschoor, Mark, Vianello, Michelangelo, Voracek, Martin, Vuu, Gina, Wagenmakers, Eric-Jan, Weerdmeester, Joanneke, Welsh, Ashlee, Westgate, Erin C., Wissink, Joeri, Wood, Michael, Woods, Andy, Wright, Emily, Wu, Sining, Zeelenberg, Marcel, and Zuni, Kellylynn

Abstract

Reproducibility is a defining feature of science, but the extent to which it characterizes current research is unknown. We conducted replications of 100 experimental and correlational studies published in three psychology journals using high-powered designs and original materials when available. Replication effects were half the magnitude of original effects, representing a substantial decline. Ninety-seven percent of original studies had statistically significant results. Thirty-six percent of replications had statistically significant results; 47% of original effect sizes were in the 95% confidence interval of the replication effect size; 39% of effects were subjectively rated to have replicated the original result; and if no bias in original results is assumed, combining original and replication results left 68% with statistically significant effects. Correlational tests suggest that replication success was better predicted by the strength of original evidence than by characteristics of the original and replication teams.

Published
2015

21. Estimating the reproducibility of psychological science

Author

Social Networks, Solidarity and Inequality, Anderson, Joanna E., Aarts, Alexander A., Anderson, Christopher J., Attridge, Peter R., Attwood, Angela, Axt, Jordan, Babel, Molly, Bahník, Štěpán, Baranski, Erica, Barnett-Cowan, Michael, Bartmess, Elizabeth, Beer, Jennifer, Bell, Raoul, Bentley, Heather, Beyan, Leah, Binion, Grace, Borsboom, Denny, Bosch, Annick, Bosco, Frank A., Bowman, Sara D., Brandt, Mark J., Braswell, Erin, Brohmer, Hilmar, Brown, Benjamin T., Brown, Kristina, Brüning, Jovita, Calhoun-Sauls, Ann, Callahan, Shannon P., Chagnon, Elizabeth, Chandler, Jesse, Chartier, Christopher R., Cheung, Felix, Christopherson, Cody D., Cillessen, Linda, Clay, Russ, Cleary, Hayley, Cloud, Mark D., Conn, Michael, Cohoon, Johanna, Columbus, Simon, Cordes, Andreas, Costantini, Giulio, Alvarez, Leslie D Cramblet, Cremata, Ed, Crusius, Jan, DeCoster, Jamie, DeGaetano, Michelle A., Penna, Nicolás Delia, Den Bezemer, Bobby, Deserno, Marie K., Devitt, Olivia, Dewitte, Laura, Dobolyi, David G., Dodson, Geneva T., Donnellan, M. Brent, Donohue, Ryan, Dore, Rebecca A., Dorrough, Angela, Dreber, Anna, Dugas, Michelle, Dunn, Elizabeth W., Easey, Kayleigh, Eboigbe, Sylvia, Eggleston, Casey, Embley, Jo, Epskamp, Sacha, Errington, Timothy M., Estel, Vivien, Farach, Frank J., Feather, Jenelle, Fedor, Anna, Fernández-Castilla, Belén, Fiedler, Susann, Field, James G., Fitneva, Stanka A., Flagan, Taru, Forest, Amanda L., Forsell, Eskil, Foster, Joshua D., Frank, Michael C., Frazier, Rebecca S., Fuchs, Heather, Gable, Philip, Galak, Jeff, Galliani, Elisa Maria, Gampa, Anup, Garcia, Sara, Gazarian, Douglas, Gilbert, Elizabeth, Giner-Sorolla, Roger, Glöckner, Andreas, Goellner, Lars, Goh, Jin X., Goldberg, Rebecca, Goodbourn, Patrick T., Gordon-McKeon, Shauna, Gorges, Bryan, Gorges, Jessie, Goss, Justin, Graham, Jesse, Grange, James A., Gray, Jeremy, Hartgerink, Chris, Hartshorne, Joshua, Hasselman, Fred, Hayes, Timothy, Heikensten, Emma, Henninger, Felix, Hodsoll, John, Holubar, Taylor, Hoogendoorn, Gea, Humphries, Denise J., Hung, Cathy O Y, Immelman, Nathali, Irsik, Vanessa C., Jahn, Georg, Jäkel, Frank, Jekel, Marc, Johannesson, Magnus, Johnson, Larissa G., Johnson, David J., Johnson, Kate M., Johnston, William J., Jonas, Kai, Joy-Gaba, Jennifer A., Kappes, Heather Barry, Kelso, Kim, Kidwell, Mallory C., Kim, Seung Kyung, Kirkhart, Matthew, Kleinberg, Bennett, Knežević, Goran, Kolorz, Franziska Maria, Kossakowski, Jolanda J., Krause, Robert Wilhelm, Krijnen, Job, Kuhlmann, Tim, Kunkels, Yoram K., Kyc, Megan M., Lai, Calvin K., Laique, Aamir, Lakens, Daniël, Lane, Kristin A., Lassetter, Bethany, Lazarević, Ljiljana B., Le Bel, Etienne P., Lee, Key Jung, Lee, Minha, Lemm, Kristi, Levitan, Carmel A., Lewis, Melissa, Lin, Lin, Lin, Stephanie, Lippold, Matthias, Loureiro, Darren, Luteijn, Ilse, MacKinnon, Sean, Mainard, Heather N., Marigold, Denise C., Martin, Daniel P., Martinez, Tylar, Masicampo, E. J., Matacotta, Josh, Mathur, Maya, May, Michael, Mechin, Nicole, Mehta, Pranjal, Meixner, Johannes, Melinger, Alissa, Miller, Jeremy K., Miller, Mallorie, Moore, Katherine, Möschl, Marcus, Motyl, Matt, Müller, Stephanie M., Munafo, Marcus, Neijenhuijs, Koen I., Nervi, Taylor, Nicolas, Gandalf, Nilsonne, Gustav, Nosek, Brian A., Nuijten, Michèle B., Olsson, Catherine, Osborne, Colleen, Ostkamp, Lutz, Pavel, Misha, Penton-Voak, Ian S., Perna, Olivia, Pernet, Cyril, Perugini, Marco, Pipitone, R. Nathan, Pitts, Michael, Plessow, Franziska, Prenoveau, Jason M., Rahal, Rima Maria, Ratliff, Kate A., Reinhard, David, Renkewitz, Frank, Ricker, Ashley A., Rigney, Anastasia, Rivers, Andrew M., Roebke, Mark, Rutchick, Abraham M., Ryan, Robert S., Sahin, Onur, Saide, Anondah, Sandstrom, Gillian M., Santos, David, Saxe, Rebecca, Schlegelmilch, René, Schmidt, Kathleen, Scholz, Sabine, Seibel, Larissa, Selterman, Dylan Faulkner, Shaki, Samuel, Simpson, William B., Sinclair, H. Colleen, Skorinko, Jeanine L M, Slowik, Agnieszka, Snyder, Joel S., Soderberg, Courtney, Sonnleitner, Carina, Spencer, Nick, Spies, Jeffrey R., Steegen, Sara, Stieger, Stefan, Strohminger, Nina, Sullivan, Gavin B., Talhelm, Thomas, Tapia, Megan, Te Dorsthorst, Anniek, Thomae, Manuela, Thomas, Sarah L., Tio, Pia, Traets, Frits, Tsang, Steve, Tuerlinckx, Francis, Turchan, Paul, Valášek, Milan, Van't Veer, Anna E., Van Aert, Robbie, Van Assen, Marcel, Van Bork, Riet, Van De Ven, Mathijs, Van Den Bergh, Don, Van Der Hulst, Marije, Van Dooren, Roel, Van Doorn, Johnny, Van Renswoude, Daan R., Van Rijn, Hedderik, Vanpaemel, Wolf, Echeverría, Alejandro Vásquez, Vazquez, Melissa, Velez, Natalia, Vermue, Marieke, Verschoor, Mark, Vianello, Michelangelo, Voracek, Martin, Vuu, Gina, Wagenmakers, Eric Jan, Weerdmeester, Joanneke, Welsh, Ashlee, Westgate, Erin C., Wissink, Joeri, Wood, Michael, Woods, Andy, Wright, Emily, Wu, Sining, Zeelenberg, Marcel, Zuni, Kellylynn, Social Networks, Solidarity and Inequality, Anderson, Joanna E., Aarts, Alexander A., Anderson, Christopher J., Attridge, Peter R., Attwood, Angela, Axt, Jordan, Babel, Molly, Bahník, Štěpán, Baranski, Erica, Barnett-Cowan, Michael, Bartmess, Elizabeth, Beer, Jennifer, Bell, Raoul, Bentley, Heather, Beyan, Leah, Binion, Grace, Borsboom, Denny, Bosch, Annick, Bosco, Frank A., Bowman, Sara D., Brandt, Mark J., Braswell, Erin, Brohmer, Hilmar, Brown, Benjamin T., Brown, Kristina, Brüning, Jovita, Calhoun-Sauls, Ann, Callahan, Shannon P., Chagnon, Elizabeth, Chandler, Jesse, Chartier, Christopher R., Cheung, Felix, Christopherson, Cody D., Cillessen, Linda, Clay, Russ, Cleary, Hayley, Cloud, Mark D., Conn, Michael, Cohoon, Johanna, Columbus, Simon, Cordes, Andreas, Costantini, Giulio, Alvarez, Leslie D Cramblet, Cremata, Ed, Crusius, Jan, DeCoster, Jamie, DeGaetano, Michelle A., Penna, Nicolás Delia, Den Bezemer, Bobby, Deserno, Marie K., Devitt, Olivia, Dewitte, Laura, Dobolyi, David G., Dodson, Geneva T., Donnellan, M. Brent, Donohue, Ryan, Dore, Rebecca A., Dorrough, Angela, Dreber, Anna, Dugas, Michelle, Dunn, Elizabeth W., Easey, Kayleigh, Eboigbe, Sylvia, Eggleston, Casey, Embley, Jo, Epskamp, Sacha, Errington, Timothy M., Estel, Vivien, Farach, Frank J., Feather, Jenelle, Fedor, Anna, Fernández-Castilla, Belén, Fiedler, Susann, Field, James G., Fitneva, Stanka A., Flagan, Taru, Forest, Amanda L., Forsell, Eskil, Foster, Joshua D., Frank, Michael C., Frazier, Rebecca S., Fuchs, Heather, Gable, Philip, Galak, Jeff, Galliani, Elisa Maria, Gampa, Anup, Garcia, Sara, Gazarian, Douglas, Gilbert, Elizabeth, Giner-Sorolla, Roger, Glöckner, Andreas, Goellner, Lars, Goh, Jin X., Goldberg, Rebecca, Goodbourn, Patrick T., Gordon-McKeon, Shauna, Gorges, Bryan, Gorges, Jessie, Goss, Justin, Graham, Jesse, Grange, James A., Gray, Jeremy, Hartgerink, Chris, Hartshorne, Joshua, Hasselman, Fred, Hayes, Timothy, Heikensten, Emma, Henninger, Felix, Hodsoll, John, Holubar, Taylor, Hoogendoorn, Gea, Humphries, Denise J., Hung, Cathy O Y, Immelman, Nathali, Irsik, Vanessa C., Jahn, Georg, Jäkel, Frank, Jekel, Marc, Johannesson, Magnus, Johnson, Larissa G., Johnson, David J., Johnson, Kate M., Johnston, William J., Jonas, Kai, Joy-Gaba, Jennifer A., Kappes, Heather Barry, Kelso, Kim, Kidwell, Mallory C., Kim, Seung Kyung, Kirkhart, Matthew, Kleinberg, Bennett, Knežević, Goran, Kolorz, Franziska Maria, Kossakowski, Jolanda J., Krause, Robert Wilhelm, Krijnen, Job, Kuhlmann, Tim, Kunkels, Yoram K., Kyc, Megan M., Lai, Calvin K., Laique, Aamir, Lakens, Daniël, Lane, Kristin A., Lassetter, Bethany, Lazarević, Ljiljana B., Le Bel, Etienne P., Lee, Key Jung, Lee, Minha, Lemm, Kristi, Levitan, Carmel A., Lewis, Melissa, Lin, Lin, Lin, Stephanie, Lippold, Matthias, Loureiro, Darren, Luteijn, Ilse, MacKinnon, Sean, Mainard, Heather N., Marigold, Denise C., Martin, Daniel P., Martinez, Tylar, Masicampo, E. J., Matacotta, Josh, Mathur, Maya, May, Michael, Mechin, Nicole, Mehta, Pranjal, Meixner, Johannes, Melinger, Alissa, Miller, Jeremy K., Miller, Mallorie, Moore, Katherine, Möschl, Marcus, Motyl, Matt, Müller, Stephanie M., Munafo, Marcus, Neijenhuijs, Koen I., Nervi, Taylor, Nicolas, Gandalf, Nilsonne, Gustav, Nosek, Brian A., Nuijten, Michèle B., Olsson, Catherine, Osborne, Colleen, Ostkamp, Lutz, Pavel, Misha, Penton-Voak, Ian S., Perna, Olivia, Pernet, Cyril, Perugini, Marco, Pipitone, R. Nathan, Pitts, Michael, Plessow, Franziska, Prenoveau, Jason M., Rahal, Rima Maria, Ratliff, Kate A., Reinhard, David, Renkewitz, Frank, Ricker, Ashley A., Rigney, Anastasia, Rivers, Andrew M., Roebke, Mark, Rutchick, Abraham M., Ryan, Robert S., Sahin, Onur, Saide, Anondah, Sandstrom, Gillian M., Santos, David, Saxe, Rebecca, Schlegelmilch, René, Schmidt, Kathleen, Scholz, Sabine, Seibel, Larissa, Selterman, Dylan Faulkner, Shaki, Samuel, Simpson, William B., Sinclair, H. Colleen, Skorinko, Jeanine L M, Slowik, Agnieszka, Snyder, Joel S., Soderberg, Courtney, Sonnleitner, Carina, Spencer, Nick, Spies, Jeffrey R., Steegen, Sara, Stieger, Stefan, Strohminger, Nina, Sullivan, Gavin B., Talhelm, Thomas, Tapia, Megan, Te Dorsthorst, Anniek, Thomae, Manuela, Thomas, Sarah L., Tio, Pia, Traets, Frits, Tsang, Steve, Tuerlinckx, Francis, Turchan, Paul, Valášek, Milan, Van't Veer, Anna E., Van Aert, Robbie, Van Assen, Marcel, Van Bork, Riet, Van De Ven, Mathijs, Van Den Bergh, Don, Van Der Hulst, Marije, Van Dooren, Roel, Van Doorn, Johnny, Van Renswoude, Daan R., Van Rijn, Hedderik, Vanpaemel, Wolf, Echeverría, Alejandro Vásquez, Vazquez, Melissa, Velez, Natalia, Vermue, Marieke, Verschoor, Mark, Vianello, Michelangelo, Voracek, Martin, Vuu, Gina, Wagenmakers, Eric Jan, Weerdmeester, Joanneke, Welsh, Ashlee, Westgate, Erin C., Wissink, Joeri, Wood, Michael, Woods, Andy, Wright, Emily, Wu, Sining, Zeelenberg, Marcel, and Zuni, Kellylynn

Published
2015

22. Altered FXR signalling is associated with bile acid dysmetabolism in short bowel syndrome-associated liver disease

Author

Pereira-Fantini, Prue M., primary, Lapthorne, Susan, additional, Joyce, Susan A., additional, Dellios, Nicole L., additional, Wilson, Guineva, additional, Fouhy, Fiona, additional, Thomas, Sarah L., additional, Scurr, Michelle, additional, Hill, Colin, additional, Gahan, Cormac G.M., additional, Cotter, Paul D., additional, Fuller, Peter J., additional, Hardikar, Winita, additional, and Bines, Julie E., additional

Published
2014
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23. Seeking vision and voice in poetic dwelling

Author

Thomas, Sarah L. Sawin and Thomas, Sarah L. Sawin

Abstract

Narrative inductive accounts of my teaching practices create a compelling medium for exposing and challenging silences in education, while seeking and reinforcing enduring ideals. By stressing active perception, reflection, creative experimentation and invention in multiple mediums (e.g., literary, visual arts and performing arts) within my classroom, students and I experience challenge and hope. As we strive for meaning, the classroom discourse gains texture rich with honesty, pursuit, imaginative leaps, failures and tough ethical questions revealing our shared humanity and fostering agency for learning. The singular and collective stories of teaching that unfold provide direction for the field of education because within them the reader is able to closely observe and interrogate existing practices while better discerning the possible. Poetic dwelling spaces emerge, opening up content rather than pinning it down definitively. Alongside my students we suspend preoccupations with outcomes and linger in ideas. We recursively move from global to local perspectives, asking ourselves who we are amidst larger theoretical conversations about pedagogy and how our practices are informed by the larger scope. We privilege artistry, science and humanity as arteries comprising the bloodstream of good teaching and learning. Each chapter invites such poetic dwelling spaces for both reader and author to enhance meaning through stimulating professional reflection and imagination, considering what constitutes effective teaching/learning practices while probing professional identity. At the core of my professional identity I find over and over again that claiming the identity piece—teacher as inventor vs. reproducer—generates meaningful learning with students, among colleagues, and within myself. The voice and vision for education I personally gain are expressed and the significances for learners and learning revealed. My hope is that these accounts incite a collective educator voice

Published
2009

24. GLP-2 administration results in increased proliferation but paradoxically an adverse outcome in a juvenile piglet model of short bowel syndrome

Author

Pereira-Fantini, Prue M, Nagy, Eva S, Thomas, Sarah L, Taylor, Russell G, Sourial, Magdy, Paris, Monique C J, Holst, Jens Juul, Fuller, Peter J, Bines, Julie E, Pereira-Fantini, Prue M, Nagy, Eva S, Thomas, Sarah L, Taylor, Russell G, Sourial, Magdy, Paris, Monique C J, Holst, Jens Juul, Fuller, Peter J, and Bines, Julie E

Abstract

OBJECTIVE: The objective of the present study was to examine the effect of glucagon-like peptide-2 (GLP-2) administration in a piglet, juvenile model of short bowel syndrome.MATERIALS AND METHODS: Four-week-old piglets underwent either a sham operation or 75% small bowel resection. Postoperatively, piglets received either polymeric infant formula diet or the diet and subcutaneous human recombinant GLP-2 (1600 microg/day for 7 days, 800 microg/day thereafter). Food intake was monitored throughout the experiment, and stool and serum samples obtained fortnightly. After the piglets were killed, tissues were obtained from the duodenum, jejunum, ileum, and terminal ileum, and used for morphological and functional analysis.RESULTS: Treatment with GLP-2 resulted in significantly increased numbers of proliferating and apoptotic cells in the ileum of sham and small bowel resection piglets (P < 0.05). GLP-2 administration resulted in decreased weight gain, serum albumin, and disaccharidases in both sham and small bowel resection piglets (P < 0.001 compared with polymeric infant formula diet alone).CONCLUSIONS: This is the first study to our knowledge to examine the effect of GLP-2 administration in a juvenile short bowel syndrome model. Contrary to adult rodent studies, administration of GLP-2 resulted in adverse outcomes including reduced ability to gain weight; decreased serum albumin, tissue maltase, and sucrase; and villous atrophy. We anticipate this information will have important implications for future paediatric clinical trials.

Published
2008

25. What You Don't Know Can Hurt You: Missing Data and Partial Credit Model Estimates.

Author

Thomas, Sarah L., Schmidt, Karen M., Erbacher, Monica K., and Bergeman, Cindy S.

Subjects
MISSING data (Statistics), ESTIMATION theory, MATHEMATICAL models, ITEM response theory, PARAMETER estimation, QUESTIONNAIRES
Abstract

The authors investigated the effect of missing completely at random (MCAR) item responses on partial credit model (PCM) parameter estimates in a longitudinal study of Positive Affect. Participants were 307 adults from the older cohort of the Notre Dame Study of Health and Well-Being (Bergeman and Deboeck, 2014) who completed questionnaires including Positive Affect items for 56 days. Additional missing responses were introduced to the data, randomly replacing 20%, 50%, and 70% of the responses on each item and each day with missing values, in addition to the existing missing data. Results' indicated that item locations and person trait level measures diverged from the original estimates as the level of degradation from induced missing data increased. In addition, standard errors of these estimates increased with the level of degradation. Thus, MCAR data does damage the quality and precision of PCM estimates. [ABSTRACT FROM AUTHOR]

Published
2016

35. Graduating 4th year radiology residents' perception of optimal imaging modalities for neoplasm and trauma: a pilot study from four U. S. universities.

Author

Junior, Jorge Elias, Semelka, Richard C., Altun, Ersan, Balci, N. Cem, Thomas, Sarah L., Hussain, Shahid M., and Martin, Diego R.

Subjects
RADIOGRAPHY, DIAGNOSTIC imaging, TUMORS, WOUNDS & injuries, BRAIN injuries, X-ray diffraction
Abstract

Copyright of Radiologia Brasileira is the property of Radiologia Brasileira and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2011
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37. Estimating the reproducibility of psychological science

Author

Open Science Collaboration, Aarts, Alexander A., Anderson, Joanna E., Anderson, Christopher J., Attridge, Peter R., Attwood, Angela, Axt, Jordan, Babel, Molly, Bahník, Štěpán, Baranski, Erica, Barnett-Cowan, Michael, Bartmess, Elizabeth, Beer, Jennifer, Bell, Raoul, Bentley, Heather, Beyan, Leah, Binion, Grace, Borsboom, Denny, Bosch, Annick, Bosco, Frank A., Bowman, Sara D., Brandt, Mark J., Braswell, Erin, Brohmer, Hilmar, Brown, Benjamin T., Brown, Kristina, Brüning, Jovita, Calhoun-Sauls, Ann, Callahan, Shannon P., Chagnon, Elizabeth, Chandler, Jesse, Chartier, Christopher R., Cheung, Felix, Christopherson, Cody D., Cillessen, Linda, Clay, Russ, Cleary, Hayley, Cloud, Mark D., Cohn, Michael, Cohoon, Johanna, Columbus, Simon, Cordes, Andreas, Costantini, Giulio, Cramblet Alvarez, Leslie D., Cremata, Ed, Crusius, Jan, DeCoster, Jamie, DeGaetano, Michelle A., Della Penna, Nicolás, den Bezemer, Bobby, Deserno, Marie K., Devitt, Olivia, Dewitte, Laura, Dobolyi, David G., Dodson, Geneva T., Donnellan, M. Brent, Donohue, Ryan, Dore, Rebecca A., Dorrough, Angela, Dreber, Anna, Dugas, Michelle, Dunn, Elizabeth W., Easey, Kayleigh, Eboigbe, Sylvia, Eggleston, Casey, Embley, Jo, Epskamp, Sacha, Errington, Timothy M., Estel, Vivien, Farach, Frank J., Feather, Jenelle, Fedor, Anna, Fernández-Castilla, Belén, Fiedler, Susann, Field, James G., Fitneva, Stanka A., Flagan, Taru, Forest, Amanda L., Forsell, Eskil, Foster, Joshua D., Frank, Michael C., Frazier, Rebecca S., Fuchs, Heather, Gable, Philip, Galak, Jeff, Galliani, Elisa Maria, Gampa, Anup, Garcia, Sara, Gazarian, Douglas, Gilbert, Elizabeth, Giner-Sorolla, Roger, Glöckner, Andreas, Goellner, Lars, Goh, Jin X., Goldberg, Rebecca, Goodbourn, Patrick T., Gordon-McKeon, Shauna, Gorges, Bryan, Gorges, Jessie, Goss, Justin, Graham, Jesse, Grange, James A., Gray, Jeremy, Hartgerink, Chris, Hartshorne, Joshua, Hasselman, Fred, Hayes, Timothy, Heikensten, Emma, Henninger, Felix, Hodsoll, John, Holubar, Taylor, Hoogendoorn, Gea, Humphries, Denise J., Hung, Cathy O.Y., Immelman, Nathali, Irsik, Vanessa C., Jahn, Georg, Jäkel, Frank, Jekel, Marc, Johannesson, Magnus, Johnson, Larissa G., Johnson, David J., Johnson, Kate M., Johnston, William J., Jonas, Kai, Joy-Gaba, Jennifer A., Kappes, Heather Barry, Kelso, Kim, Kidwell, Mallory C., Kim, Seung Kyung, Kirkhart, Matthew, Kleinberg, Bennett, Knežević, Goran, Kolorz, Franziska Maria, Kossakowski, Jolanda J., Krause, Robert Wilhelm, Krijnen, Job, Kuhlmann, Tim, Kunkels, Yoram K., Kyc, Megan M., Lai, Calvin K., Laique, Aamir, Lakens, Daniël, Lane, Kristin A., Lassetter, Bethany, Lazarević, Ljiljana B., LeBel, Etienne P., Lee, Key Jung, Lee, Minha, Lemm, Kristi, Levitan, Carmel A., Lewis, Melissa, Lin, Lin, Lin, Stephanie, Lippold, Matthias, Loureiro, Darren, Luteijn, Ilse, Mackinnon, Sean, Mainard, Heather N., Marigold, Denise C., Martin, Daniel P., Martinez, Tylar, Masicampo, E.J., Matacotta, Josh, Mathur, Maya B., May, Michael, Mehta, Pranjal, Meixner, Johannes, Melinger, Alissa, Miller, Jeremy K., Miller, Mallorie, Moore, Katherine, Möschl, Marcus, Motyl, Matt, Müller, Stephanie M., Munafo, Marcus, Neijenhuijs, Koen I., Nervi, Taylor, Nicolas, Gandalf, Nilsonne, Gustav, Nosek, Brian A., Nuijten, Michèle B., Olsson, Catherine, Osborne, Colleen, Ostkamp, Lutz, Pavel, Misha, Penton-Voak, Ian S., Perna, Olivia, Pernet, Cyril, Perugini, Marco, Pipitone, R. Nathan, Pitts, Michael, Plessow, Franziska, Prenoveau, Jason M., Rahal, Rima-Maria, Ratliff, Kate A., Reinhard, David, Renkewitz, Frank, Ricker, Ashley A., Rigney, Anastasia, Rivers, Andrew M., Roebke, Mark, Rutchick, Abraham M., Ryan, Robert S., Sahin, Onur, Saide, Anondah, Sandstrom, Gillian M., Santos, David, Saxe, Rebecca, Schlegelmilch, René, Schmidt, Kathleen, Scholz, Sabine, Seibel, Larissa, Selterman, Dylan Faulkner, Shaki, Samuel, Simpson, William B., Sinclair, Colleen, Skorinko, Jeanine L., Slowik, Agnieszka, Snyder, Joel S., Soderberg, Courtney, Sonnleitner, Carina, Spencer, Nick, Spies, Jeffrey R., Steegen, Sara, Stieger, Stefan, Strohminger, Nina, Sullivan, Gavin B., Talhelm, Thomas, Tapia, Megan, te Dorsthorst, Anniek, Thomae, Manuela, Thomas, Sarah L., Tio, Pia, Traets, Frits, Tsang, Steve, Tuerlinckx, Francis, Turchan, Paul, Valášek, Milan, van ‘t Veer, A. E., Van Aert, Robbie, van Assen, Marcel, van Bork, Riet, van de Ven, Mathijs, van den Bergh, Donald, van der Hulst, Marije, van Dooren, Roel, van Doorn, Johnny, van Renswoude, Daan R., van Rijn, Hedderik, Vanpaemel, Wolf, Vásquez Echeverría, Alejandro, Vazquez, Melissa, Velez, Natalia, Vermue, Marieke, Verschoor, Mark, Vianello, Michelangelo, Voracek, Martin, Vuu, Gina, Wagenmakers, Eric-Jan, Weerdmeester, Joanneke, Welsh, Ashlee, Westgate, Erin C., Wissink, Joeri, Wood, Michael, Woods, Andy, Wright, Emily, Wu, Sining, Zeelenberg, Marcel, Zuni, Kellylynn, Open Science Collaboration, Aarts, Alexander A., Anderson, Joanna E., Anderson, Christopher J., Attridge, Peter R., Attwood, Angela, Axt, Jordan, Babel, Molly, Bahník, Štěpán, Baranski, Erica, Barnett-Cowan, Michael, Bartmess, Elizabeth, Beer, Jennifer, Bell, Raoul, Bentley, Heather, Beyan, Leah, Binion, Grace, Borsboom, Denny, Bosch, Annick, Bosco, Frank A., Bowman, Sara D., Brandt, Mark J., Braswell, Erin, Brohmer, Hilmar, Brown, Benjamin T., Brown, Kristina, Brüning, Jovita, Calhoun-Sauls, Ann, Callahan, Shannon P., Chagnon, Elizabeth, Chandler, Jesse, Chartier, Christopher R., Cheung, Felix, Christopherson, Cody D., Cillessen, Linda, Clay, Russ, Cleary, Hayley, Cloud, Mark D., Cohn, Michael, Cohoon, Johanna, Columbus, Simon, Cordes, Andreas, Costantini, Giulio, Cramblet Alvarez, Leslie D., Cremata, Ed, Crusius, Jan, DeCoster, Jamie, DeGaetano, Michelle A., Della Penna, Nicolás, den Bezemer, Bobby, Deserno, Marie K., Devitt, Olivia, Dewitte, Laura, Dobolyi, David G., Dodson, Geneva T., Donnellan, M. Brent, Donohue, Ryan, Dore, Rebecca A., Dorrough, Angela, Dreber, Anna, Dugas, Michelle, Dunn, Elizabeth W., Easey, Kayleigh, Eboigbe, Sylvia, Eggleston, Casey, Embley, Jo, Epskamp, Sacha, Errington, Timothy M., Estel, Vivien, Farach, Frank J., Feather, Jenelle, Fedor, Anna, Fernández-Castilla, Belén, Fiedler, Susann, Field, James G., Fitneva, Stanka A., Flagan, Taru, Forest, Amanda L., Forsell, Eskil, Foster, Joshua D., Frank, Michael C., Frazier, Rebecca S., Fuchs, Heather, Gable, Philip, Galak, Jeff, Galliani, Elisa Maria, Gampa, Anup, Garcia, Sara, Gazarian, Douglas, Gilbert, Elizabeth, Giner-Sorolla, Roger, Glöckner, Andreas, Goellner, Lars, Goh, Jin X., Goldberg, Rebecca, Goodbourn, Patrick T., Gordon-McKeon, Shauna, Gorges, Bryan, Gorges, Jessie, Goss, Justin, Graham, Jesse, Grange, James A., Gray, Jeremy, Hartgerink, Chris, Hartshorne, Joshua, Hasselman, Fred, Hayes, Timothy, Heikensten, Emma, Henninger, Felix, Hodsoll, John, Holubar, Taylor, Hoogendoorn, Gea, Humphries, Denise J., Hung, Cathy O.Y., Immelman, Nathali, Irsik, Vanessa C., Jahn, Georg, Jäkel, Frank, Jekel, Marc, Johannesson, Magnus, Johnson, Larissa G., Johnson, David J., Johnson, Kate M., Johnston, William J., Jonas, Kai, Joy-Gaba, Jennifer A., Kappes, Heather Barry, Kelso, Kim, Kidwell, Mallory C., Kim, Seung Kyung, Kirkhart, Matthew, Kleinberg, Bennett, Knežević, Goran, Kolorz, Franziska Maria, Kossakowski, Jolanda J., Krause, Robert Wilhelm, Krijnen, Job, Kuhlmann, Tim, Kunkels, Yoram K., Kyc, Megan M., Lai, Calvin K., Laique, Aamir, Lakens, Daniël, Lane, Kristin A., Lassetter, Bethany, Lazarević, Ljiljana B., LeBel, Etienne P., Lee, Key Jung, Lee, Minha, Lemm, Kristi, Levitan, Carmel A., Lewis, Melissa, Lin, Lin, Lin, Stephanie, Lippold, Matthias, Loureiro, Darren, Luteijn, Ilse, Mackinnon, Sean, Mainard, Heather N., Marigold, Denise C., Martin, Daniel P., Martinez, Tylar, Masicampo, E.J., Matacotta, Josh, Mathur, Maya B., May, Michael, Mehta, Pranjal, Meixner, Johannes, Melinger, Alissa, Miller, Jeremy K., Miller, Mallorie, Moore, Katherine, Möschl, Marcus, Motyl, Matt, Müller, Stephanie M., Munafo, Marcus, Neijenhuijs, Koen I., Nervi, Taylor, Nicolas, Gandalf, Nilsonne, Gustav, Nosek, Brian A., Nuijten, Michèle B., Olsson, Catherine, Osborne, Colleen, Ostkamp, Lutz, Pavel, Misha, Penton-Voak, Ian S., Perna, Olivia, Pernet, Cyril, Perugini, Marco, Pipitone, R. Nathan, Pitts, Michael, Plessow, Franziska, Prenoveau, Jason M., Rahal, Rima-Maria, Ratliff, Kate A., Reinhard, David, Renkewitz, Frank, Ricker, Ashley A., Rigney, Anastasia, Rivers, Andrew M., Roebke, Mark, Rutchick, Abraham M., Ryan, Robert S., Sahin, Onur, Saide, Anondah, Sandstrom, Gillian M., Santos, David, Saxe, Rebecca, Schlegelmilch, René, Schmidt, Kathleen, Scholz, Sabine, Seibel, Larissa, Selterman, Dylan Faulkner, Shaki, Samuel, Simpson, William B., Sinclair, Colleen, Skorinko, Jeanine L., Slowik, Agnieszka, Snyder, Joel S., Soderberg, Courtney, Sonnleitner, Carina, Spencer, Nick, Spies, Jeffrey R., Steegen, Sara, Stieger, Stefan, Strohminger, Nina, Sullivan, Gavin B., Talhelm, Thomas, Tapia, Megan, te Dorsthorst, Anniek, Thomae, Manuela, Thomas, Sarah L., Tio, Pia, Traets, Frits, Tsang, Steve, Tuerlinckx, Francis, Turchan, Paul, Valášek, Milan, van ‘t Veer, A. E., Van Aert, Robbie, van Assen, Marcel, van Bork, Riet, van de Ven, Mathijs, van den Bergh, Donald, van der Hulst, Marije, van Dooren, Roel, van Doorn, Johnny, van Renswoude, Daan R., van Rijn, Hedderik, Vanpaemel, Wolf, Vásquez Echeverría, Alejandro, Vazquez, Melissa, Velez, Natalia, Vermue, Marieke, Verschoor, Mark, Vianello, Michelangelo, Voracek, Martin, Vuu, Gina, Wagenmakers, Eric-Jan, Weerdmeester, Joanneke, Welsh, Ashlee, Westgate, Erin C., Wissink, Joeri, Wood, Michael, Woods, Andy, Wright, Emily, Wu, Sining, Zeelenberg, Marcel, and Zuni, Kellylynn

Abstract

Reproducibility is a defining feature of science, but the extent to which it characterizes current research is unknown. We conducted replications of 100 experimental and correlational studies published in three psychology journals using high-powered designs and original materials when available. Replication effects were half the magnitude of original effects, representing a substantial decline. Ninety-seven percent of original studies had statistically significant results. Thirty-six percent of replications had statistically significant results; 47% of original effect sizes were in the 95% confidence interval of the replication effect size; 39% of effects were subjectively rated to have replicated the original result; and if no bias in original results is assumed, combining original and replication results left 68% with statistically significant effects. Correlational tests suggest that replication success was better predicted by the strength of original evidence than by characteristics of the original and replication teams.

38. Changes in the colon microbiota and intestinal cytokine gene expression following minimal intestinal surgery.

Author

Lapthorne S, Bines JE, Fouhy F, Dellios NL, Wilson G, Thomas SL, Scurr M, Stanton C, Cotter PD, and Pereira-Fantini PM

Subjects
Animals, Animals, Newborn, Bacteria classification, Bacteria genetics, Colitis genetics, Colitis immunology, Colitis metabolism, Colitis microbiology, Cytokines immunology, Cytokines metabolism, Dysbiosis, Female, Gene Expression Regulation, High-Throughput Nucleotide Sequencing, Ileitis genetics, Ileitis immunology, Ileitis metabolism, Ileitis microbiology, Ileum immunology, Ileum metabolism, Ileum microbiology, Swine, Time Factors, Bacteria isolation & purification, Colon immunology, Colon metabolism, Colon microbiology, Cytokines genetics, Digestive System Surgical Procedures adverse effects, Ileum surgery, Inflammation Mediators immunology, Inflammation Mediators metabolism, Microbiota
Abstract

Aim: To investigate the impact of minor abdominal surgery on the caecal microbial population and on markers of gut inflammation., Methods: Four week old piglets were randomly allocated to a no-surgery "control" group (n = 6) or a "transection surgery" group (n = 5). During the transection surgery procedure, a conventional midline incision of the lower abdominal wall was made and the small intestine was transected at a site 225 cm proximal to the ileocaecal valve, a 2 cm segment was removed and the intestine was re-anastomosed. Piglets received a polymeric infant formula diet throughout the study period and were sacrificed at two weeks post-surgery. Clinical outcomes including weight, stool consistency and presence of stool fat globules were monitored. High throughput DNA sequencing of colonic content was used to detect surgery-related disturbances in microbial composition at phylum, family and genus level. Diversity and richness estimates were calculated for the control and minor surgery groups. As disturbances in the gut microbial community are linked to inflammation we compared the gene expression of key inflammatory cytokines (TNF, IL1B, IL18, IL12, IL8, IL6 and IL10) in ileum, terminal ileum and colon mucosal extracts obtained from control and abdominal surgery groups at two weeks post-surgery., Results: Changes in the relative abundance of bacterial species at family and genus level were confined to bacterial members of the Proteobacteria and Bacteroidetes phyla. Family level compositional shifts included a reduction in the relative abundance of Enterobacteriaceae (22.95 ± 5.27 vs 2.07 ± 0.72, P < 0.01), Bacteroidaceae (2.54 ± 0.56 vs 0.86 ± 0.43, P < 0.05) and Rhodospirillaceae (0.40 ± 0.14 vs 0.00 ± 0.00, P < 0.05) following transection surgery. Similarly, at the genus level, changes associated with transection surgery were restricted to members of the Proteobacteria and Bacteroidetes phyla and included decreased relative abundance of Enterobacteriaceae (29.20 ± 6.74 vs 2.88 ± 1.08, P < 0.01), Alistipes (4.82 ± 1.73 vs 0.18 ± 0.13, P < 0.05) and Thalassospira (0.53 ± 0.19 vs 0.00 ± 0.00, P < 0.05). Surgery-associated microbial dysbiosis was accompanied by increased gene expression of markers of inflammation. Within the ileum IL6 expression was decreased (4.46 ± 1.60 vs 0.24 ± 0.06, P < 0.05) following transection surgery. In the terminal ileum, gene expression of TNF was decreased (1.51 ± 0.13 vs 0.80 ± 0.16, P < 0.01) and IL18 (1.21 ± 0.18 vs 2.13 ± 0.24, P < 0.01), IL12 (1.04 ± 0.16 vs 1.82 ± 0.32, P < 0.05) and IL10 (1.04 ± 0.06 vs 1.43 ± 0.09, P < 0.01) gene expression increased following transection surgery. Within the colon, IL12 (0.72 ± 0.13 vs 1.78 ± 0.28, P < 0.01) and IL10 (0.98 ± 0.02 vs 1.95 ± 0.14, P < 0.01) gene expression were increased following transection surgery., Conclusion: This study suggests that minor abdominal surgery in infants, results in long-term alteration of the colonic microbial composition and persistent gastrointestinal inflammation.

Published
2015
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39. Colostrum supplementation restores insulin-like growth factor -1 levels and alters muscle morphology following massive small bowel resection.

Author

Pereira-Fantini PM, Thomas SL, Taylor RG, Nagy E, Sourial M, Fuller PJ, and Bines JE

Subjects
Animals, Disease Models, Animal, Female, Insulin-Like Growth Factor Binding Proteins metabolism, Intestine, Small metabolism, Intestine, Small surgery, Muscle, Smooth anatomy & histology, Muscle, Smooth cytology, Muscle, Smooth drug effects, RNA, Messenger metabolism, Random Allocation, Receptor, IGF Type 1 metabolism, Short Bowel Syndrome metabolism, Short Bowel Syndrome surgery, Swine, Weight Gain drug effects, Adaptation, Physiological, Colostrum chemistry, Insulin-Like Growth Factor I metabolism, Muscle, Smooth physiology, Proteins therapeutic use
Abstract

Background: Colostrum protein concentrate (CPC) contains a high level of insulin-like growth factor-1 (IGF-1). IGF-1 and IGF binding protein (IGFBPs) may play an important role during the postresection adaptation response. As smooth muscle is an important site for IGF-1 action in the intestine, this study aims to (1) investigate the effect of CPC supplementation on circulating levels and tissue expression of IGF-1, IGF-1 receptor, and IGFBPs following massive small bowel resection (MSBR), and (2) characterize the effect of CPC on the muscular adaptation response following MSBR., Methods: Four-week-old piglets underwent either a 75% MSBR or sham operation. Piglets received either a polymeric infant formula (PIF) diet or PIF supplemented with CPC for 8 weeks. Serum was analyzed by enzyme-linked immunosorbent assay, and ileal tissue assessed by molecular and histological analysis., Results: There was no difference in IGF-1 or IGFBPs mRNA among groups. CPC treatment resulted in significant increases in circulating levels of IGF-1 and IGFBPs and a concurrent increase in muscle width and the number of muscle cells, but did not alter muscle cell size., Conclusions: Strategies aimed at increasing muscular adaptation may decrease Gl transit and allow greater mucosal contact time for absorption. We have shown that CPC supplementation following resection results in increased levels of circulating IGF-1, IGFBP-2, and IGFBP-3 and muscular hypertrophy. Our results suggest that IGF-1 and its mediators may play a role in the muscular adaptation response and warrant further exploration as a treatment option for short bowel syndrome.

Published
2008
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