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1. The Prognostic Role of the Number of Involved Structures in Thymic Epithelial Tumors: Results from the ESTS Database

Author

Chiappetta, Marco, Lococo, Filippo, Sassorossi, Carolina, Aigner, Clemens, Ploenes, Till, Van Raemdonck, Dirk, Vanluyten, Cedric, Van Schil, Paul, Agrafiotis, Apostolos C., Guerrera, Francesco, Lyberis, Paraskevas, Casiraghi, Monica, Spaggiari, Lorenzo, Zisis, Charalambos, Magou, Christina, Moser, Bernhard, Bauer, Jonas, Thomas, Pascal Alexandre, Brioude, Geoffrey, Passani, Stefano, Zsanto, Zalan, Sperduti, Isabella, and Margaritora, Stefano

Published
2024
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2. ASO Visual Abstract: The Prognostic Role of the Number of Involved Structures in Thymic Epithelial Tumors: Results from the ESTS Database

Author

Chiappetta, Marco, Lococo, Filippo, Sassorossi, Carolina, Aigner, Clemens, Ploenes, Till, Van Raemdonck, Dirk, Vanluyten, Cedric, Van Schil, Paul, Agrafiotis, Apostolos, Guerrera, Francesco, Lyberis, Paraskevas, Casiraghi, Monica, Spaggiari, Lorenzo, Zisis, Charalambos, Magou, Christina, Moser, Bernhard, Bauer, Jonas, Thomas, Pascal Alexandre, Brioude, Geoffrey, Passani, Stefano, Zsanto, Zalan, Sperduti, Isabella, and Margaritora, Stefano

Published
2024
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3. ASO Author Reflections: The Number of Involved Structures is a Promising Prognostic Factor in Thymic Epithelial Tumors

Author

Chiappetta, Marco, Lococo, Filippo, Sassorossi, Carolina, Aigner, Clemens, Ploenes, Till, Van Raemdonck, Dirk, Vanluyten, Cedric, Van Schil, Paul, Agrafiotis, Apostolos, Guerrera, Francesco, Lyberis, Paraskevas, Casiraghi, Monica, Spaggiari, Lorenzo, Zisis, Charalambos, Magou, Christina, Moser, Bernhard, Bauer, Jonas, Thomas, Pascal Alexandre, Brioude, Geoffrey, Passani, Stefano, Zsanto, Zalan, Sperduti, Isabella, and Margaritora, Stefano

Published
2024
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4. Correction: ASO Author Reflections: The Number of Involved Structures is a Promising Prognostic Factor in Thymic Epithelial Tumors

Author

Chiappetta, Marco, Lococo, Filippo, Sassorossi, Carolina, Aigner, Clemens, Ploenes, Till, Van Raemdonck, Dirk, Vanluyten, Cedric, Van Schil, Paul, Agrafiotis, Apostolos, Guerrera, Francesco, Lyberis, Paraskevas, Casiraghi, Monica, Spaggiari, Lorenzo, Zisis, Charalambos, Magou, Christina, Moser, Bernhard, Bauer, Jonas, Thomas, Pascal Alexandre, Brioude, Geoffrey, Passani, Stefano, Zsanto, Zalan, Sperduti, Isabella, and Margaritora, Stefano

Published
2024
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5. Correction: The Prognostic Role of the Number of Involved Structures in Thymic Epithelial Tumors: Results from the ESTS Database

Author

Chiappetta, Marco, Lococo, Filippo, Sassorossi, Carolina, Aigner, Clemens, Ploenes, Till, Van Raemdonck, Dirk, Vanluyten, Cedric, Van Schil, Paul, Agrafiotis, Apostolos C., Guerrera, Francesco, Lyberis, Paraskevas, Casiraghi, Monica, Spaggiari, Lorenzo, Zisis, Charalambos, Magou, Christina, Moser, Bernhard, Bauer, Jonas, Thomas, Pascal Alexandre, Brioude, Geoffrey, Passani, Stefano, Zsanto, Zalan, Sperduti, Isabella, and Margaritora, Stefano

Published
2024
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6. Correction: ASO Visual Abstract: The Prognostic Role of the Number of Involved Structures in Thymic Epithelial Tumors: Results from the ESTS Database

Author

Chiappetta, Marco, Lococo, Filippo, Sassorossi, Carolina, Aigner, Clemens, Ploenes, Till, Van Raemdonck, Dirk, Vanluyten, Cedric, Van Schil, Paul, Agrafiotis, Apostolos, Guerrera, Francesco, Lyberis, Paraskevas, Casiraghi, Monica, Spaggiari, Lorenzo, Zisis, Charalambos, Magou, Christina, Moser, Bernhard, Bauer, Jonas, Thomas, Pascal Alexandre, Brioude, Geoffrey, Passani, Stefano, Zsanto, Zalan, Sperduti, Isabella, and Margaritora, Stefano

Published
2024
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11. Outcome of Patients With Resected Early-Stage Non-small Cell Lung Cancer and EGFR Mutations: Results From the IFCT Biomarkers France Study

Author

Mordant, Pierre, MD, PhD, Brosseau, Solenn, Milleron, Bernard, Santelmo, Nicola, Fraboulet-Moreau, Séverine, Besse, Benjamin, Langlais, Alexandra, Gossot, Dominique, Thomas, Pascal-Alexandre, Pujol, Jean-Louis, Ricordel, Charles, Madelaine, Jeannick, Lamy, Régine, Audigier-Valette, Clarisse, Missy, Pascale, Blons, Hélène, Barlesi, Fabrice, and Westeel, Virginie

Published
2023
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14. Postoperative radiotherapy versus no postoperative radiotherapy in patients with completely resected non-small-cell lung cancer and proven mediastinal N2 involvement (Lung ART, IFCT 0503): an open-label, randomised, phase 3 trial

Author

Le Pechoux, Cecile, Pourel, Nicolas, Barlesi, Fabrice, Lerouge, Delphine, Antoni, Delphine, Lamezec, Bruno, Nestle, Ursula, Boisselier, Pierre, Dansin, Eric, Paumier, Amaury, Peignaux, Karine, Thillays, François, Zalcman, Gerard, Madelaine, Jeannick, Pichon, Eric, Larrouy, Anne, Lavole, Armelle, Argo-Leignel, Delphine, Derollez, Marc, Faivre-Finn, Corinne, Hatton, Matthew Q, Riesterer, Oliver, Bouvier-Morel, Emilie, Dunant, Ariane, Edwards, John G, Thomas, Pascal Alexandre, Mercier, Olaf, and Bardet, Aurelie

Published
2022
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15. Survival outcomes following urgent lung transplantation in France and the USA.

Author

Roussel, Arnaud, Sage, Edouard, Falcoz, Pierre-Emmanuel, Thomas, Pascal Alexandre, Castier, Yves, Fadel, Elie, Le Pimpec-Barthes, Françoise, Tronc, François, Jougon, Jacques, Lacoste, Philippe, Claustre, Johanna, Brouchet, Laurent, Dorent, Richard, Cantu, Edward, Harhay, Michael, Porcher, Raphaël, and Mordant, Pierre

Subjects
MEDICAL care, SURVIVAL rate, LUNG transplantation, ARTIFICIAL blood circulation, PROPORTIONAL hazards models, ARTIFICIAL respiration, BRONCHIECTASIS, BLOOD group incompatibility
Published
2024
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16. Real-world outcomes of lobectomy, segmentectomy and wedge resection for the treatment of stage c-IA lung carcinoma.

Author

Thomas, Pascal Alexandre, Seguin-Givelet, Agathe, Pages, Pierre-Benoît, Alifano, Marco, Brouchet, Laurent, Falcoz, Pierre-Emmanuel, Baste, Jean-Marc, Glorion, Matthieu, Belaroussi, Yaniss, Filaire, Marc, Heyndrickx, Maxime, Loundou, Anderson, Fourdrain, Alex, Dahan, Marcel, Boyer, Laurent, and group, EPITHOR working

Subjects
*PROPENSITY score matching, *OVERALL survival, *THORACIC surgery, *TUMOR microenvironment, *SURVIVAL rate, *LOBECTOMY (Lung surgery)
Abstract

OBJECTIVES To determine safety and survival outcomes associated with lobectomy, segmentectomy and wedge resection for early-stage lung cancer by quiring the French population-based registry EPIdemiology in THORacic surgery (EPITHOR). METHODS Retrospective analysis of 19 452 patients with stage c IA lung carcinoma who underwent lobectomy, segmentectomy or wedge resection between 2016 and 2022 with curative-intent. Main outcome measures were 90-day mortality and 5-year overall survival estimates. Proportional hazards regression and propensity score matching were used to adjust outcomes for key patient, tumour and practice environment factors. RESULTS The treatment distribution was 72.2% for lobectomy, 21.5% for segmentectomy and 6.3% for wedge. Unadjusted 90-day mortality rates were 1.6%, 1.2% and 1.1%, respectively (P  = 0.10). Unadjusted 5-year overall survival estimates were 80%, 78% and 70%, with significant inter-group survival curves differences (P  < 0.0001). Multivariable proportional hazards regression showed that wedge was associated with worse overall survival [adjusted hazard ratio (AHR), 1.23 (95% confidence interval 1.03–1.47); P  = 0.021] compared with lobectomy, while no significant difference was disclosed when comparing segmentectomy to lobectomy (1.08 [0.97–1.20]; P  = 0.162). The three-way propensity score analyses confirmed similar 90-day mortality rate for wedge resection and segmentectomy compared with lobectomy (hazard ratio: 0.43; 95% confidence interval 0.16–1.11; P  = 0.081 and 0.99; 0.48–2.10; P  = 0.998, respectively), but poorer overall survival (1.45; 1.13–1.86; P  = 0.003 and 1.31; 1–1.71; P  = 0.048, respectively). CONCLUSIONS Wedge resection was associated with comparable 90-day mortality but lower overall survival when compared to lobectomy. Overall, all types of sublobar resections may not offer equivalent oncologic effectiveness in real-world settings. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Protective effect of height on long-term survival of resectable lung cancer: a new feature of the lung cancer paradox

Author

Daffré, Elisa, primary, Porcher, Raphaël, additional, Iannelli, Antonio, additional, Prieto, Mathilde, additional, Brouchet, Laurent, additional, Falcoz, Pierre Emmanuel, additional, Le Pimpec Barthes, Françoise, additional, Pages, Pierre Benoit, additional, Thomas, Pascal Alexandre, additional, Dahan, Marcel, additional, and Alifano, Marco, additional

Published
2024
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23. Adenocarcinoma of the oesophagogastric junction Siewert II: An oesophageal cancer better cured with total gastrectomy

Author

Arnaud, Jean Pierre, Balon, Jean Michel, Bonnetain, Frank, Borie, Frederic, Brachet, Dorothée, Brigand, Cécile, Carrere, Nicolas, D'Journo, Xavier Benoit, Dechelotte, Pierre, Delpero, Jean Robert, Dhari, Abdenaceur, Fabre, Sylvain, Fernandez, Manuel, Flamein, Renaud, Gillet, Brigitte, Glaise, Aude, Glehen, Olivier, Goéré, Diane, Guilbert, Marie, Guiramand, Jérôme, Hebbar, Mohamed, Huten, Noël, Leteurtre, Emmanuelle, Kraft, Kevin, Louis, Damien, Mabrut, Jean Yves, Mathieu, Benjamin, Michalak, Sophie, Michot, Francis, Millat, Bertrand, Lefevre, Jeremie H., Peschaud, Fédérique, Pezet, Denis, Pichot-Delahaye, Virginie, Pocard, Marc, Poisson, Ariane, Prudhomme, Michel, Regimbeau, Jean Marc, Thiébot, Timothée, Thomas, Pascal- Alexandre, Tsilividis, Basile, Vandois, Florence, Voron, Thibault, Gronnier, Caroline, Pasquer, Arnaud, Thereaux, Jeremie, Gagniere, Johan, Lebreton, Gil, Meunier, Bernard, Collet, Denis, Piessen, Guillaume, and Paye, François

Published
2019
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24. Resected EGFR -mutated non-small-cell lung cancers: incidence and outcomes in a European population (GFPC Exerpos Study).

Author

Auliac, Jean-Bernard, Thomas, Pascal-Alexandre, Bylicki, Olivier, Guisier, Florian, Curcio, Hubert, AlainVegnenègre, Swalduz, Aurelie, Wislez, Marie, Le Treut, Jacques, Decroisette, Chantal, Basse, Victor, Falchero, Lionel, De Chabot, Gonzague, Moreau, Diane, Huchot, Eric, Lupo Mansuet, Audrey, Blons, Helene, Chouaïd, Christos, and Greillier, Laurent

Abstract

Background: Few epidemiological data are available on surgically treated Caucasian patients with non-small-cell lung cancers (NSCLCs) harboring epidermal growth factor receptor (EGFR) mutations. The main objective of this study was to describe, in the real-world setting, these patients' incidence, clinical, and tumoral characteristics. Methods: The participating centers included all consecutive localized non-squamous NSCLC patients undergoing surgery between January 2018 and December 2019 in France. EGFR status was determined retrospectively when not available before surgery. Results: The study includes 1391 no squamous NSCLC patients from 16 centers; EGFR status was determined before surgery in 692 (49.7%) of the cases and conducted as part of the study for 699 (50.3%); 171 (12.3%) were EGFR mutated; median age: 70 (range: 36–88) years; female: 59.6%; never smokers: 75.7%; non-squamous histology 97.7%, programmed death ligand-1 expression 0%/1–49%/⩾50 in 60.5%/25.7%/13.8%, respectively. Surgery was predominantly lobectomy (81%) or segmentectomy (14.9%), with systematic lymph node dissection in 95.9%. Resection completeness was R0 for 97%. Post-surgery staging was as follows: IA: 52%, IB: 16%, IIA: 4%, IIB: 10%, IIIA: 16%, and IIIB: 0.05%; EGFR mutation exon was Del19/exon 21 (L858R)/20/18 in 37.4%/36.8%/14%, and 6.4% of cases, respectively; 31 (18%) patients received adjuvant treatment (chemotherapy: 93%, EGFR tyrosine kinase inhibitor: 0%, radiotherapy: 20%). After a median follow-up of 31 (95% confidence interval: 29.6–33.1) months, 45 (26%) patients relapsed: 11/45 (24%) locally and 34 (76%) with metastatic progression. Median disease-free survival (DFS) and overall survival were not reached and 3-year DFS was 60%. Conclusion: This real-world analysis provides the incidence and outcomes of resected EGFR -mutated NSCLCs in a European patient cohort. [ABSTRACT FROM AUTHOR]

Published
2024
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28. Lung Ultrasound Findings in the Postanesthesia Care Unit Are Associated With Outcome After Major Surgery: A Prospective Observational Study in a High-Risk Cohort

Author

Zieleskiewicz, Laurent, Papinko, Mickael, Lopez, Alexandre, Baldovini, Alice, Fiocchi, David, Meresse, Zoe, Boussuges, Alain, Thomas, Pascal Alexandre, Berdah, Stephane, Creagh-Brown, Ben, Bouhemad, Belaid, Futier, Emmanuel, Resseguier, Noémie, Antonini, François, Duclos, Gary, and Leone, Marc

Published
2021
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29. Multidisciplinary Tumor Board Decision Making for Postoperative Radiotherapy in Thymic Epithelial Tumors: Insights from the RYTHMIC Prospective Cohort

Author

Basse, Clémence, Thureau, Sébastien, Bota, Suzanna, Dansin, Eric, Thomas, Pascal-Alexandre, Pichon, Eric, Lena, Hervé, Massabeau, Carole, Clément-Duchene, Christelle, Massard, Gilbert, Westeel, Virginie, Quantin, Xavier, Oulkhouir, Youssef, Danhier, Serge, Lerouge, Delphine, Tanguy, Ronan, Thillays, François, Le Pechoux, Cécile, Dubray, Bernard, Thiberville, Luc, Besse, Benjamin, and Girard, Nicolas

Published
2017
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30. Prediction of survival after lung transplantation at one year (SALTO cohort) using information available at different key time-points

Author

Belaroussi, Yaniss, primary, Hustache-Castaing, Romain, additional, Maury, Jean-Michel, additional, Lehot, Laurent, additional, Rodriguez, Arnaud, additional, Demant, Xavier, additional, Rozé, Hadrien, additional, Brioude, Geoffrey, additional, D’Journo, Xavier-Benoit, additional, Drevet, Gabrielle, additional, Tronc, Francois, additional, Mathoulin-Pélissier, Simone, additional, Jougon, Jacques, additional, Thomas, Pascal-Alexandre, additional, and Thumerel, Matthieu, additional

Published
2023
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34. Effectiveness of Surgeon-Performed Paravertebral Block Analgesia for Minimally Invasive Thoracic Surgery: A Randomized Clinical Trial.

Author

Chenesseau, Josephine, Fourdrain, Alex, Pastene, Bruno, Charvet, Aude, Rivory, Adrien, Baumstarck, Karine, Bouabdallah, Ilies, Trousse, Delphine, Boulate, David, Brioude, Geoffrey, Gust, Lucile, Vasse, Matthieu, Braggio, Cesare, Mora, Pierre, Labarriere, Ambroise, Zieleskiewicz, Laurent, Leone, Marc, Thomas, Pascal Alexandre, and D'Journo, Xavier-Benoit

Published
2023
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36. Oropharyngeal and nasopharyngeal decontamination with chlorhexidine gluconate in lung cancer surgery: a randomized clinical trial

Author

D’Journo, Xavier Benoit, Falcoz, Pierre-Emmanuel, Alifano, Marco, Le Rochais, Jean-Philippe, D’Annoville, Thomas, Massard, Gilbert, Regnard, Jean Francois, Icard, Philippe, Marty-Ane, Charles, Trousse, Delphine, Doddoli, Christophe, Orsini, Bastien, Edouard, Sophie, Million, Matthieu, Lesavre, Nathalie, Loundou, Anderson, Baumstarck, Karine, Peyron, Florence, Honoré, Stephane, Dizier, Stéphanie, Charvet, Aude, Leone, Marc, Raoult, Didier, Papazian, Laurent, and Thomas, Pascal Alexandre

Published
2018
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38. Prognostic score and sex-specific nomograms to predict survival in resectable lung cancer: a French nationwide study from the Epithor cohort database

Author

Alifano, Marco, primary, Daffré, Elisa, additional, Brouchet, Laurent, additional, Falcoz, Pierre Emmanuel, additional, Le Pimpec Barthes, Françoise, additional, Pages, Pierre Benoit, additional, Thomas, Pascal Alexandre, additional, Dahan, Marcel, additional, and Porcher, Raphael, additional

Published
2023
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39. Lung Transplantation for Primary Ciliary Dyskinesia and Kartagener Syndrome: A Multicenter Study

Author

Marro, Matteo, primary, Leiva-Juárez, Miguel M., additional, D’Ovidio, Frank, additional, Chan, Justin, additional, Van Raemdonck, Dirk, additional, Ceulemans, Laurens Joseph, additional, Moreno, Paula, additional, Kindelan, Antonio Alvarez, additional, Krueger, Thorsten, additional, Koutsokera, Angela, additional, Ehrsam, Jonas Peter, additional, Inci, Ilhan, additional, Yazicioglu, Alkin, additional, Yekeler, Erdal, additional, Boffini, Massimo, additional, Brioude, Geoffrey, additional, Thomas, Pascal Alexandre, additional, Pizanis, Nikolaus, additional, Aigner, Clemens, additional, Schiavon, Marco, additional, Rea, Federico, additional, Anile, Marco, additional, Venuta, Federico, additional, and Keshavjee, Shaf, additional

Published
2023
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40. Risk Prediction Model of 90-Day Mortality after Esophagectomy for Cancer

Author

D'Journo, Xavier Benoit, Boulate, David, Fourdrain, Alex, Loundou, Anderson, van Berge Henegouwen, Mark I, Gisbertz, Suzanne S, O'Neill, J Robert, Hoelscher, Arnulf, Piessen, Guillaume, van Lanschot, Jan, Wijnhoven, Bas, Jobe, Blair, Davies, Andrew, Schneider, Paul M, Pera, Manuel, Nilsson, Magnus, Nafteux, Philippe, Kitagawa, Yuko, Morse, Christopher R, Hofstetter, Wayne, Molena, Daniela, Jimmy Bok-Yan, So, Immanuel, Arul, Parsons, Simon L, Larsen, Michael Hareskov, Dolan, James P, Wood, Stephanie G, Maynard, Nick, Smithers, Mark, Puig, Sonia, Law, Simon, Wong, Ian, Kennedy, Andrew, Kangning, Wang, Reynolds, John V, Pramesh, C S, Ferguson, Mark, Darling, Gail, Schröder, Wolfgang, Bludau, Marc, Underwood, Tim, van Hillegersberg, Richard, Chang, Andrew, Cecconello, Ivan, Ribeiro, Ulysses, de Manzoni, Giovanni, Rosati, Riccardo, Kuppusamy, Madhankumar, Thomas, Pascal Alexandre, Low, Donald E, Weindelmayer, J., Surgery, CCA - Cancer Treatment and Quality of Life, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, D'Journo, Xavier Benoit, Boulate, David, Fourdrain, Alex, Loundou, Anderson, van Berge Henegouwen, Mark I, Gisbertz, Suzanne S, O'Neill, J Robert, Hoelscher, Arnulf, Piessen, Guillaume, van Lanschot, Jan, Wijnhoven, Ba, Jobe, Blair, Davies, Andrew, Schneider, Paul M, Pera, Manuel, Nilsson, Magnu, Nafteux, Philippe, Kitagawa, Yuko, Morse, Christopher R, Hofstetter, Wayne, Molena, Daniela, So, Jimmy Bok-Yan, Immanuel, Arul, Parsons, Simon L, Larsen, Michael Hareskov, Dolan, James P, Wood, Stephanie G, Maynard, Nick, Smithers, Mark, Puig, Sonia, Law, Simon, Wong, Ian, Kennedy, Andrew, Kangning, Wang, Reynolds, John V, Pramesh, C S, Ferguson, Mark, Darling, Gail, Schröder, Wolfgang, Bludau, Marc, Underwood, Tim, van Hillegersberg, Richard, Chang, Andrew, Cecconello, Ivan, Ribeiro, Ulysse, de Manzoni, Giovanni, Rosati, Riccardo, Kuppusamy, Madhankumar, Thomas, Pascal Alexandre, and Low, Donald E

Subjects
Male, medicine.medical_specialty, Time Factors, Esophageal Neoplasms, medicine.medical_treatment, 030230 surgery, Logistic regression, Risk Assessment, 03 medical and health sciences, 0302 clinical medicine, Postoperative Complications, SDG 3 - Good Health and Well-being, Risk Factors, Internal medicine, medicine, Humans, Retrospective Studies, Original Investigation, Models, Statistical, Performance status, Receiver operating characteristic, business.industry, Mortality rate, Esophageal cancer, Middle Aged, medicine.disease, Prognosis, Esophagectomy, 030220 oncology & carcinogenesis, Cohort, Surgery, Female, business, Body mass index
Abstract

Importance: Ninety-day mortality rates after esophagectomy are an indicator of the quality of surgical oncologic management. Accurate risk prediction based on large data sets may aid patients and surgeons in making informed decisions. Objective: To develop and validate a risk prediction model of death within 90 days after esophagectomy for cancer using the International Esodata Study Group (IESG) database, the largest existing prospective, multicenter cohort reporting standardized postoperative outcomes. Design, Setting, and Participants: In this diagnostic/prognostic study, we performed a retrospective analysis of patients from 39 institutions in 19 countries between January 1, 2015, and December 31, 2019. Patients with esophageal cancer were randomly assigned to development and validation cohorts. A scoring system that predicted death within 90 days based on logistic regression ß coefficients was conducted. A final prognostic score was determined and categorized into homogeneous risk groups that predicted death within 90 days. Calibration and discrimination tests were assessed between cohorts. Exposures: Esophageal resection for cancer of the esophagus and gastroesophageal junction. Main Outcomes and Measures: All-cause postoperative 90-day mortality. Results: A total of 8403 patients (mean [SD] age, 63.6 [9.0] years; 6641 [79.0%] male) were included. The 30-day mortality rate was 2.0% (n = 164), and the 90-day mortality rate was 4.2% (n = 353). Development (n = 4172) and validation (n = 4231) cohorts were randomly assigned. The multiple logistic regression model identified 10 weighted point variables factored into the prognostic score: age, sex, body mass index, performance status, myocardial infarction, connective tissue disease, peripheral vascular disease, liver disease, neoadjuvant treatment, and hospital volume. The prognostic scores were categorized into 5 risk groups: very low risk (score, =1; 90-day mortality, 1.8%), low risk (score, 0; 90-day mortality, 3.0%), medium risk (score, -1 to -2; 90-day mortality, 5.8%), high risk (score, -3 to -4: 90-day mortality, 8.9%), and very high risk (score, =-5; 90-day mortality, 18.2%). The model was supported by nonsignificance in the Hosmer-Lemeshow test. The discrimination (area under the receiver operating characteristic curve) was 0.68 (95% CI, 0.64-0.72) in the development cohort and 0.64 (95% CI, 0.60-0.69) in the validation cohort. Conclusions and Relevance: In this study, on the basis of preoperative variables, the IESG risk prediction model allowed stratification of an individual patient's risk of death within 90 days after esophagectomy. These data suggest that this model can help in the decision-making process when esophageal cancer surgery is being considered and in informed consent.

Published
2021

41. Lung Transplantation for Primary Ciliary Dyskinesia and Kartagener Syndrome : A Multicenter Study

Author

Marro, Matteo, Leiva-Juárez, Miguel M., D'Ovidio, Frank, Chan, Justin, Van Raemdonck, Dirk, Ceulemans, Laurens Joseph, Moreno, Paula, Kindelan, Antonio Alvarez, Krueger, Thorsten, Koutsokera, Angela, Ehrsam, Jonas Peter, Inci, Ilhan, Yazicioglu, Alkin, Yekeler, Erdal, Boffini, Massimo, Brioude, Geoffrey, Thomas, Pascal Alexandre, Pizanis, Nikolaus, Aigner, Clemens, Schiavon, Marco, Rea, Federico, Anile, Marco, Venuta, Federico, Keshavjee, Shaf, and D’Ovidio, Frank

Subjects
Transplantation, Kartagener Syndrome, Biopsy, Data Collection, primary graft dysfunction, Medizin, rare disease, Humans, outcomes, lung transplant, chronic lung allograft dysfunction, Retrospective Studies, Lung Transplantation
Abstract

Primary ciliary dyskinesia, with or without situs abnormalities, is a rare lung disease that can lead to an irreversible lung damage that may progress to respiratory failure. Lung transplant can be considered in end-stage disease. This study describes the outcomes of the largest lung transplant population for PCD and for PCD with situs abnormalities, also identified as Kartagener's syndrome. Retrospectively collected data of 36 patients who underwent lung transplantation for PCD from 1995 to 2020 with or without SA as part of the European Society of Thoracic Surgeons Lung Transplantation Working Group on rare diseases. Primary outcomes of interest included survival and freedom from chronic lung allograft dysfunction. Secondary outcomes included primary graft dysfunction within 72 h and the rate of rejection ≥A2 within the first year. Among PCD recipients with and without SA, the mean overall and CLAD-free survival were 5.9 and 5.2 years with no significant differences between groups in terms of time to CLAD (HR: 0.92, 95% CI: 0.27-3.14, p = 0.894) or mortality (HR: 0.45, 95% CI: 0.14-1.43, p = 0.178). Postoperative rates of PGD were comparable between groups; rejection grades ≥A2 on first biopsy or within the first year was more common in patients with SA. This study provides a valuable insight on international practices of lung transplantation in patients with PCD. Lung transplantation is an acceptable treatment option in this population. ispartof: TRANSPLANT INTERNATIONAL vol:36 ispartof: location:Switzerland status: published

Published
2023

42. Is the Epithor conversion score reliable in robotic-assisted surgery anatomical lung resection?

Author

Armand, Elsa, Fourdrain, Alex, Lafouasse, Chloé, Resseguier, Noémie, Trousse, Delphine, D'Journo, Xavier-Benoît, and Thomas, Pascal-Alexandre

Subjects
LUNG surgery, VIDEO-assisted thoracic surgery, MINIMALLY invasive procedures, PERIPHERAL vascular diseases, CHEST endoscopic surgery, ANKLE brachial index
Abstract

Open in new tab Download slide OBJECTIVES Despite an improvement in surgical abilities, the need for an intraoperative switch from a minimally invasive procedure towards an open surgery (conversion) still remains. To anticipate this risk, the Epithor conversion score (ECS) has been described for video-assisted thoracoscopic surgery (VATS). Our objective was to determine if this score, developed for VATS, is applicable in robotic-assisted thoracoscopic surgery (RATS). METHODS This was a retrospective monocentric study from January 2006 to June 2022, and data were obtained from the EPITHOR database. Patients included were those who underwent anatomic lung resection either by VATS or RATS. The ECS was calculated for all patients studied. Discrimination and calibration of the test were measured by the area under the curve and Hosmer–Lemeshow test. RESULTS A total of 1685 were included. There were 183/1299 conversions in the VATS group (14.1%) and 27/386 conversions in the RATS group (6.9%). Patients in the RATS group had fewer antiplatelet therapy and peripheral arterial disease. There were more segmentectomies in the VATS group. As for test discrimination, the area under the curve was 0.66 [0.56–0.78] in the RATS group and 0.64 [0.60–0.69] in the VATS group. Regarding the calibration, the Hosmer–Lemeshow test was not significant for both groups but more positive (better calibrated) for the VATS group (P  = 0.12) compared to the RATS group (P  = 0.08). CONCLUSIONS The ECS seems applicable for patients operated with RATS, with a correct discrimination but a lower calibration performance for patients operated with VATS. A new score could be developed to specifically anticipate conversion in patients operated on by RATS. [ABSTRACT FROM AUTHOR]

Published
2023
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43. Benignant and malignant epidemiology among surgical resections for suspicious solitary lung cancer without preoperative tissue diagnosis

Author

Armand, Elsa, primary, Boulate, David, additional, Fourdrain, Alex, additional, Nguyen, Ngoc-Anh-Thu, additional, Resseguier, Noémie, additional, Brioude, Geoffrey, additional, Trousse, Delphine, additional, Doddoli, Christophe, additional, D’journo, Xavier-Benoit, additional, and Thomas, Pascal-Alexandre, additional

Published
2022
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44. Robotic vs Thoracoscopic Anatomic Lung Resection in Obese Patients: A Propensity-Adjusted Analysis

Author

Seder, Christopher W., primary, Farrokhyar, Forough, additional, Nayak, Rahul, additional, Baste, Jean-Marc, additional, Patel, Yogita, additional, Agzarian, John, additional, Finley, Christian J., additional, Shargall, Yaron, additional, Thomas, Pascal-Alexandre, additional, Dahan, Marcel, additional, Verhoye, Jean-Philippe, additional, Mbadinga, Frankie, additional, and Hanna, Waël C., additional

Published
2022
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45. Impact of the implementation of a trauma system on compliance with evidence-based clinical management guidelines in penetrating thoracic trauma

Author

Vasse, Matthieu, primary, Leone, Marc, additional, Boyer, Laurent, additional, Michelet, Pierre, additional, Goudard, Yvain, additional, Cardinale, Michael, additional, Paris, Raphael, additional, Avaro, Jean Philippe, additional, Thomas, Pascal Alexandre, additional, and de Lesquen, Henri, additional

Published
2022
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46. Mobilisation of HLA‐F on the surface of bronchial epithelial cells and platelets in asthmatic patients

Author

Fiouane, Sabrina, primary, Chebbo, Mohamad, additional, Beley, Sophie, additional, Paganini, Julien, additional, Picard, Christophe, additional, D'Journo, Xavier‐Benoît, additional, Thomas, Pascal‐Alexandre, additional, Chiaroni, Jacques, additional, Chanez, Pascal, additional, Gras, Delphine, additional, and Di Cristofaro, Julie, additional

Published
2022
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47. Thoracic surgery in France

Author

Gossot, Dominique, primary, Saiydoun, Gabriel, additional, Leclerc, Jean-Baptiste, additional, Dahan, Marcel, additional, Thomas, Pascal Alexandre, additional, Verhoye, Jean-Philippe, additional, and Seguin-Givelet, Agathe, additional

Published
2022
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48. Multicentric evaluation of the impact of central tumour location when comparing rates of N1 upstaging in patients undergoing video-assisted and open surgery for clinical Stage I non-small-cell lung cancer†

Author

Decaluwé, Herbert, Petersen, René Horsleben, Brunelli, Alex, Pompili, Cecilia, Seguin-Givelet, Agathe, Gust, Lucile, Aigner, Clemens, Falcoz, Pierre-Emmanuel, Rinieri, Philippe, Augustin, Florian, Sokolow, Youri, Verhagen, Ad, Depypere, Lieven, Papagiannopoulos, Kostas, Gossot, Dominique, D’Journo, Xavier Benoit, Guerrera, Francesco, Baste, Jean-Marc, Schmid, Thomas, Stanzi, Alessia, Van Raemdonck, Dirk, Bardet, Jeremy, Thomas, Pascal-Alexandre, Massard, Gilbert, Fieuws, Steffen, Moons, Johnny, Dooms, Christophe, De Leyn, Paul, and Hansen, Henrik Jessen

Published
2018
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49. Associations between the severity of medical and surgical complications and perception of surgeon empathy in esophageal and gastric cancer patients

Author

Gehenne, Lucie, Lelorain, Sophie, Eveno, Clarisse, Piessen, Guillaume, Mariette, Christophe, Glehen, Olivier, d'Journo, Xavier, Mathonnet, Muriel, Regenet, Nicolas, Meunier, Bernard, Baudry, Anne-Sophie, Christophe, Véronique, Adenis, Antoine, Aparicio, Thomas, Assenat, Eric, Barret, Maximilien, Benhaim, Leonor, Benoit, Céline, Bergeat, Damien, Boige, Valérie, Borie, Fréderic, Bouche, Olivier, Bourriez, Damien, Brichon, Pierre-Yves, Brigand, Cécile, Carrere, Nicolas, Cattan, Pierre, Christou, Niki, Coffin, Benoit, Cohen, Romain, Collet, Denis, Conroy, Thierry, Dahan, Laetitia, Deguelte, Sophie, Di Fiore, Fréderic, Dousset, Bertrand, Drouillard, Antoine, Dumont, Frédéric, Elhajbi, Farid, Fabre, Jean Michel, Fabre, Joseph, Gagniere, Johan, Galais, Marie Pierre, Germain, Adeline, Geyl, Sophie, Goere, Diane, Gornet, Jean Marc, Granger, Victoire, Gronnier, Caroline, Guimbaud, Rosine, Hautefeuille, Vincent, Helyon, Morgane, Jougon, Jacques, Lebreton, Gilles, Lefevre, Jérémie, Lepage, Côme, Lievre, Astrid, Marchal, Frédéric, Mathieu, Pierre, Mathysiak, Tamara, Michot, Nicolas, Moszkowicz, David, Moussata, Driffa, Msika, Simon, Neuzillet, Cindy, Ouaissi, Medhi, Paquette, Brice, Paye, François, Penna, Christophe, Père, Guillaume, Perrier, Marine, Peschaud, Frédérique, Pezet, Denis, Phoutthsang, Valérie, Pocard, Marc, Rat, Paul, Regimbeau, Jean Marc, Renaud, Florence, Sabate, Jean-Marc, Souche, Régis, Terrebonne, Eric, Tessier, Williams, Thomas, Pascal Alexandre, Turpin, Anthony, Vaudoyer, Delphine, Vienot, Angélique, Voron, Thibault, You, Benoit, Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 (SCALab), Université de Lille-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 (CANTHER), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL), Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service de Chirurgie digestive, endocrinienne et générale [CHU Limoges], CHU Limoges, Centre hospitalier universitaire de Nantes (CHU Nantes), CHU Pontchaillou [Rennes], Centre hospitalier [Valenciennes, Nord], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Institut de Génétique Moléculaire de Montpellier (IGMM), and Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
medicine.medical_specialty, Esophageal Neoplasms, media_common.quotation_subject, education, [SDV.CAN]Life Sciences [q-bio]/Cancer, Empathy, MESH: Perception, Odds, Postoperative complications, MESH: Surgeons, 03 medical and health sciences, 0302 clinical medicine, Stomach Neoplasms, Perception, Internal medicine, Humans, Medicine, 030212 general & internal medicine, Major complication, Retrospective Studies, Cancer, media_common, Multinomial logistic regression, Surgeons, Physician-Patient Relations, MESH: Humans, business.industry, Nursing research, MESH: Retrospective Studies, Cognition, MESH: Stomach Neoplasms, medicine.disease, Patient-physician communication, MESH: Empathy, Oncology, 030220 oncology & carcinogenesis, MESH: Esophageal Neoplasms, MESH: Physician-Patient Relations, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience; Objective: To assess the impact of global physician empathy and its three subdimensions (establishing rapport, emotional and cognitive processes) on the severity of postoperative complications in a sample of cancer patients.Methods: We retrospectively analyzed data on 256 patients with esogastric cancer from the French national FREGAT database. Empathy and its subdimensions were assessed using the patient-reported CARE scale and the severity of medical and surgical complications was reported with the Clavien-Dindo classification system. The usual covariates were included in multinomial logistic regression analyses.Results: Physician empathy predicted the odds of reporting major complications. When patients perceived high empathy, they were less likely to report major complications compared to no complications (OR = .95, 95% CI = [.91-.99], p = .029). Among the three dimensions, only "establishing rapport" (OR = .84, 95% CI = [.73-.98], p = .019) and the "emotional process" (OR = .85, 95% CI = [.74-.98], p = .022) predicted major complications.Conclusions: Physician empathy is essential before surgery. Further research is needed to understand the mechanisms associating empathy with health outcomes in cancer. Physicians should be trained to establish good rapport with patients, especially in the preoperative period.

Published
2021

50. Prediction of survival after a lung transplant at 1 year (SALTO cohort) using information available at different key time points.

Author

Belaroussi, Yaniss, Hustache-Castaing, Romain, Maury, Jean-Michel, Lehot, Laurent, Rodriguez, Arnaud, Demant, Xavier, Rozé, Hadrien, Brioude, Geoffrey, D'Journo, Xavier-Benoit, Drevet, Gabrielle, Tronc, Francois, Mathoulin-Pélissier, Simone, Jougon, Jacques, Thomas, Pascal-Alexandre, and Thumerel, Matthieu

Subjects
LUNG transplantation, RECEIVER operating characteristic curves, KIDNEY transplantation, Q fever
Abstract

Open in new tab Download slide OBJECTIVES A lung transplant is the final treatment option for end-stage lung disease. We evaluated the individual risk of 1-year mortality at each stage of the lung transplant process. METHODS This study was a retrospective analysis of patients undergoing bilateral lung transplants between January 2014 and December 2019 in 3 French academic centres. Patients were randomly divided into development and validation cohorts. Three multivariable logistic regression models of 1-year mortality were applied (i) at recipient registration, (ii) the graft allocation and (iii) after the operation. The 1-year mortality was predicted for individual patients assigned to 3 risk groups at time points A to C. RESULTS The study population consisted of 478 patients with a mean (standard deviation) age of 49.0 (14.3) years. The 1-year mortality rate was 23.0%. There were no significant differences in patient characteristics between the development (n  =   319) and validation (n  =   159) cohorts. The models analysed recipient, donor and intraoperative variables. The discriminatory power (area under the receiver operating characteristic curve) was 0.67 (0.62–0.73), 0.70 (0.63–0.77) and 0.82 (0.77–0.88), respectively, in the development cohort and 0.74 (0.64–0.85), 0.76 (0.66–0.86) and 0.87 (0.79 – 0.95), respectively, in the validation cohort. Survival rates were significantly different among the low- (< 15%), intermediate- (15%–45%) and high-risk (> 45%) groups in both cohorts. CONCLUSIONS Risk prediction models allow estimation of the 1-year mortality risk of individual patients during the lung transplant process. These models may help caregivers identify high-risk patients at times A to C and reduce the risk at subsequent time points. [ABSTRACT FROM AUTHOR]

Published
2023
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