788 results on '"Thomas, Mg"'
Search Results
2. Abnormal retinal development associated with FRMD7 mutations.
- Author
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Moore, Anthony, Thomas, MG, Crosier, M, Lindsay, S, Kumar, A, Araki, M, Leroy, BP, McLean, RJ, Sheth, V, Maconachie, G, and Thomas, S
- Abstract
Idiopathic infantile nystagmus (IIN) is a genetically heterogeneous disorder, often associated with FRMD7 mutations. As the appearance of the retina is reported to be normal based on conventional fundus photography, IIN is postulated to arise from abnormal
- Published
- 2014
3. Assessing Artificial Intelligence Models to Diagnose and Differentiate Common Liver Carcinomas
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Thomas, MG, primary, Mastorides, SM, additional, Borkowski, SA, additional, Reed, JR, additional, Deland, LA, additional, Thomas, LB, additional, and Borkowski, AA, additional
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- 2022
- Full Text
- View/download PDF
4. PWE-307 A systematic review of local excision following neoadjuvant therapy for rectal cancer: are YPT0 tumours the limit?
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Messenger, DE, Hallam, S, and Thomas, MG
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- 2015
- Full Text
- View/download PDF
5. In-frame seven amino-acid duplication in AIP arose over the last 3000 years, disrupts protein interaction and stability and is associated with gigantism
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Salvatori, R, Radian, S, Diekmann, Y, Iacovazzo, D, David, A, Gabrovska, P, Grassi, G, Bussell, A-M, Stals, K, Weber, A, Quinton, R, Crowne, EC, Corazzini, V, Metherell, L, Kearney, T, Du Plessis, D, Sinha, AK, Baborie, A, Lecoq, A-L, Chanson, P, Ansorge, O, Ellard, S, Trainer, PJ, Balding, D, Thomas, MG, Korbonits, M, Salvatori, R, Radian, S, Diekmann, Y, Iacovazzo, D, David, A, Gabrovska, P, Grassi, G, Bussell, A-M, Stals, K, Weber, A, Quinton, R, Crowne, EC, Corazzini, V, Metherell, L, Kearney, T, Du Plessis, D, Sinha, AK, Baborie, A, Lecoq, A-L, Chanson, P, Ansorge, O, Ellard, S, Trainer, PJ, Balding, D, Thomas, MG, and Korbonits, M
- Abstract
OBJECTIVE: Mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene are associated with pituitary adenoma, acromegaly and gigantism. Identical alleles in unrelated pedigrees could be inherited from a common ancestor or result from recurrent mutation events. DESIGN AND METHODS: Observational, inferential and experimental study, including: AIP mutation testing; reconstruction of 14 AIP-region (8.3 Mbp) haplotypes; coalescent-based approximate Bayesian estimation of the time to most recent common ancestor (tMRCA) of the derived allele; forward population simulations to estimate current number of allele carriers; proposal of mutation mechanism; protein structure predictions; co-immunoprecipitation and cycloheximide chase experiments. RESULTS: Nine European-origin, unrelated c.805_825dup-positive pedigrees (four familial, five sporadic from the UK, USA and France) included 16 affected (nine gigantism/four acromegaly/two non-functioning pituitary adenoma patients and one prospectively diagnosed acromegaly patient) and nine unaffected carriers. All pedigrees shared a 2.79 Mbp haploblock around AIP with additional haploblocks privately shared between subsets of the pedigrees, indicating the existence of an evolutionarily recent common ancestor, the 'English founder', with an estimated median tMRCA of 47 generations (corresponding to 1175 years) with a confidence interval (9-113 generations, equivalent to 225-2825 years). The mutation occurred in a small tandem repeat region predisposed to slipped strand mispairing. The resulting seven amino-acid duplication disrupts interaction with HSP90 and leads to a marked reduction in protein stability. CONCLUSIONS: The c.805_825dup allele, originating from a common ancestor, associates with a severe clinical phenotype and a high frequency of gigantism. The mutation is likely to be the result of slipped strand mispairing and affects protein-protein interactions and AIP protein stability.
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- 2017
6. Increased Population Risk of AIP-Related Acromegaly and Gigantism in Ireland
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Radian, S, Diekmann, Y, Gabrovska, P, Holland, B, Bradley, L, Wallace, H, Stals, K, Bussell, A-M, McGurren, K, Cuesta, M, Ryan, AW, Herincs, M, Hernandez-Ramirez, LC, Holland, A, Samuels, J, Aflorei, ED, Barry, S, Denes, J, Pernicova, I, Stiles, CE, Trivellin, G, McCloskey, R, Ajzensztejn, M, Abid, N, Akker, SA, Mercado, M, Cohen, M, Thakker, RV, Baldeweg, S, Barkan, A, Musat, M, Levy, M, Orme, SM, Unterlaender, M, Burger, J, Kumar, AV, Ellard, S, McPartlin, J, McManus, R, Linden, GJ, Atkinson, B, Balding, DJ, Agha, A, Thompson, CJ, Hunter, SJ, Thomas, MG, Morrison, PJ, Korbonits, M, Radian, S, Diekmann, Y, Gabrovska, P, Holland, B, Bradley, L, Wallace, H, Stals, K, Bussell, A-M, McGurren, K, Cuesta, M, Ryan, AW, Herincs, M, Hernandez-Ramirez, LC, Holland, A, Samuels, J, Aflorei, ED, Barry, S, Denes, J, Pernicova, I, Stiles, CE, Trivellin, G, McCloskey, R, Ajzensztejn, M, Abid, N, Akker, SA, Mercado, M, Cohen, M, Thakker, RV, Baldeweg, S, Barkan, A, Musat, M, Levy, M, Orme, SM, Unterlaender, M, Burger, J, Kumar, AV, Ellard, S, McPartlin, J, McManus, R, Linden, GJ, Atkinson, B, Balding, DJ, Agha, A, Thompson, CJ, Hunter, SJ, Thomas, MG, Morrison, PJ, and Korbonits, M
- Abstract
The aryl hydrocarbon receptor interacting protein (AIP) founder mutation R304* (or p.R304* ; NM_003977.3:c.910C>T, p.Arg304Ter) identified in Northern Ireland (NI) predisposes to acromegaly/gigantism; its population health impact remains unexplored. We measured R304* carrier frequency in 936 Mid Ulster, 1,000 Greater Belfast (both in NI) and 2,094 Republic of Ireland (ROI) volunteers and in 116 NI or ROI acromegaly/gigantism patients. Carrier frequencies were 0.0064 in Mid Ulster (95%CI = 0.0027-0.013; P = 0.0005 vs. ROI), 0.001 in Greater Belfast (0.00011-0.0047) and zero in ROI (0-0.0014). R304* prevalence was elevated in acromegaly/gigantism patients in NI (11/87, 12.6%, P < 0.05), but not in ROI (2/29, 6.8%) versus non-Irish patients (0-2.41%). Haploblock conservation supported a common ancestor for all the 18 identified Irish pedigrees (81 carriers, 30 affected). Time to most recent common ancestor (tMRCA) was 2550 (1,275-5,000) years. tMRCA-based simulations predicted 432 (90-5,175) current carriers, including 86 affected (18-1,035) for 20% penetrance. In conclusion, R304* is frequent in Mid Ulster, resulting in numerous acromegaly/gigantism cases. tMRCA is consistent with historical/folklore accounts of Irish giants. Forward simulations predict many undetected carriers; geographically targeted population screening improves asymptomatic carrier identification, complementing clinical testing of patients/relatives. We generated disease awareness locally, necessary for early diagnosis and improved outcomes of AIP-related disease.
- Published
- 2017
7. A consensus model of human apolipoprotein A-I in its monomeric and lipid-free state.
- Author
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Melchior, JT, Walker, RG, Cooke, AL, Morris, J, Castleberry, M, Thompson, TB, Jones, MK, Song, HD, Rye, K-A, Oda, MN, Sorci-Thomas, MG, Thomas, MJ, Heinecke, JW, Mei, X, Atkinson, D, Segrest, JP, Lund-Katz, S, Phillips, MC, Davidson, WS, Melchior, JT, Walker, RG, Cooke, AL, Morris, J, Castleberry, M, Thompson, TB, Jones, MK, Song, HD, Rye, K-A, Oda, MN, Sorci-Thomas, MG, Thomas, MJ, Heinecke, JW, Mei, X, Atkinson, D, Segrest, JP, Lund-Katz, S, Phillips, MC, and Davidson, WS
- Abstract
Apolipoprotein (apo)A-I is an organizing scaffold protein that is critical to high-density lipoprotein (HDL) structure and metabolism, probably mediating many of its cardioprotective properties. However, HDL biogenesis is poorly understood, as lipid-free apoA-I has been notoriously resistant to high-resolution structural study. Published models from low-resolution techniques share certain features but vary considerably in shape and secondary structure. To tackle this central issue in lipoprotein biology, we assembled a team of structural biologists specializing in apolipoproteins and set out to build a consensus model of monomeric lipid-free human apoA-I. Combining novel and published cross-link constraints, small-angle X-ray scattering (SAXS), hydrogen-deuterium exchange (HDX) and crystallography data, we propose a time-averaged model consistent with much of the experimental data published over the last 40 years. The model provides a long-sought platform for understanding and testing details of HDL biogenesis, structure and function.
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- 2017
8. Ethnic disparities in infectious disease hospitalisations in the first year of life in New Zealand
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Hobbs, MR, Morton, SM, Atatoa-Carr, P, Ritchie, SR, Thomas, MG, Saraf, R, Chelimo, C, Harnden, A, Camargo, CA, and Grant, CC
- Subjects
Hospitalization ,Male ,Native Hawaiian or Other Pacific Islander ,Databases, Factual ,Risk Factors ,Humans ,Infant ,Female ,Health Status Disparities ,Communicable Diseases ,White People ,New Zealand - Abstract
Aim Infectious disease (ID) hospitalisation rates are increasing in New Zealand (NZ), especially in pre-school children, and Māori and Pacific people. We aimed to identify risk factors for ID hospitalisation in infancy within a birth cohort of NZ children, and to identify differences in risk factors between ethnic groups. Methods We investigated an established cohort of 6846 NZ children, born in 2009–2010, with linkage to a national data set of hospitalisations. We used multivariable logistic regression to obtain odds ratios (OR) for factors associated with ID hospitalisation in the first year of life, firstly for all children, and then separately for Māori or Pacific children. Results In the whole cohort, factors associated with ID hospitalisation were Māori (OR: 1.49, 95% CI: 1.17–1.89) or Pacific (2.51; 2.00–3.15) versus European maternal ethnicity, male gender (1.32; 1.13–1.55), low birthweight (1.94, 1.39–2.66), exclusive breastfeeding for Factors associated with ID hospitalisation for Māori infants were high household deprivation (2.16, 1.06–5.02) and maternal smoking (1.48, 1.02–2.14); and for Pacific infants were delayed immunisation (1.72, 1.23–2.38), maternal experience of health-care racism (2.20, 1.29–3.70) and maternal smoking (1.59, 1.10–2.29). Conclusions Māori and Pacific children in NZ experience a high burden of ID hospitalisation. Some risk factors, for example maternal smoking, are shared, while others are ethnic-specific. Interventions aimed at preventing ID hospitalisations should address both shared and ethnic-specific factors.
- Published
- 2016
9. Synthesis and summary of patient-reported outcome measures to inform the development of a core outcome set in colorectal cancer surgery
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McNair, A, Whistance, RN, Forsythe, RO, Rees, J, Jones, JE, Pullyblank, AM, Avery, K, Brookes, ST, Thomas, MG, Sylvester, PA, Russell, A, Oliver, A, Morton, D, Kennedy, R, Jayne, DG, Huxtable, R, Hackett, R, Dutton, SJ, Coleman, MG, Card, M, Brown, J, Blazeby, JM, and CONSENSUS-CRC working group
- Subjects
female genital diseases and pregnancy complications - Abstract
Aim: Patient reported outcome measures (PROMs) are standard in the assessment of colorectal cancer (CRC) treatment, but the range and complexity of available PROMs may be hindering evidence synthesis. This systematic review aimed to 1) summarise PROMs in studies of CRC surgery and 2) categorise PRO content to inform the future development of an agreed minimum 'core' outcome set to be measured in all trials. Method: All PROMs were identified from a systematic review of prospective CRC surgical studies. The type and frequency of PROMs in each study were summarized, and numbers of items documented. All items were extracted and independently categorized by content by two researchers into 'health domains' and discrepancies discussed with a patient and expert. Domain popularity and distribution of items were summarized. Results: 58 different PROMs were identified from the 104 included studies. There were 23 generic, 4 cancer specific, 11 disease and 16 symptom specific questionnaires, and 3 ad hoc measures. The most frequently used PROM was the EORTC QLQ-C30 (50 studies), and most PROMs (40,69%) were used in only one study. Detailed examination of the 50 available measures identified 917 items, which were categorized into 51 domains. The domains comprising the most items were 'anxiety' (n=85,9.2%), 'fatigue' (n=67,7.3%), and 'physical function' (n=63,6.9%). No domains were included in all PROMs Conclusion: There is major heterogeneity of PRO measurement and wide variation in content assessed by PROMs available for CRC. A core outcome set will improve PRO outcome measurement and reporting in CRC trials.
- Published
- 2015
10. The Cost-Effectiveness of Bariatric Surgery in Germany, France, Italy and the United Kingdom
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Belarbi, S, primary, Kusel, J, additional, and Thomas, MG, additional
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- 2016
- Full Text
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11. [Untitled]
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Thomas Mg, Santa Coloma Ta, Boccacci Gl, and Correale J
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Myosin light-chain kinase ,Kinase ,macromolecular substances ,General Medicine ,Biology ,Immunoglobulin light chain ,Biochemistry ,Oligodendrocyte ,Cell biology ,Cellular and Molecular Neuroscience ,Myelin ,medicine.anatomical_structure ,Myosin ,medicine ,Phosphorylation ,Rho-associated protein kinase - Abstract
Mature oligodendrocytes emit numerous myelinating processes. Force generating molecules are required for process outgrowth and spreading. We have analyzed the effect of the myosin II light chain kinase inhibitors ML-7 and ML-9 in cultured oligodendrocytes. Both drugs affect oligodendrocyte cell shape, provoking a retraction of high order processes. Our results suggest that the adhesion of the myelinating processes to the substrate depends on MLC phosphorylation, thus likely implicating myosin IIA.
- Published
- 2002
12. The Greeks in the West: genetic signatures of the Hellenic colonisation in southern Italy and Sicily
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Tofanelli, S, BRISIGHELLI, FRANCESCA, Anagnostou, P, Busby, GBJ, Ferri, G, Thomas, MG, Taglioli, L, Rudan, I, Zemunik, T, Hayward, C, Bolnick, D, Romano, V, Cali, F, Luiselli, D, Shepherd, GB, Tusa, S, Facella, A, Capelli, C, Tofanelli, S, BRISIGHELLI, FRANCESCA, Anagnostou, P, Busby, GBJ, Ferri, G, Thomas, MG, Taglioli, L, Rudan, I, Zemunik, T, Hayward, C, Bolnick, D, Romano, V, Cali, F, Luiselli, D, Shepherd, GB, Tusa, S, Facella, A, and Capelli, C
- Published
- 2015
13. Evidence for a Common Origin of Blacksmiths and Cultivators in the Ethiopian Ari within the Last 4500 Years: Lessons for Clustering-Based Inference
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Di Rienzo, A, van Dorp, L, Balding, D, Myers, S, Pagani, L, Tyler-Smith, C, Bekele, E, Tarekegn, A, Thomas, MG, Bradman, N, Hellenthal, G, Di Rienzo, A, van Dorp, L, Balding, D, Myers, S, Pagani, L, Tyler-Smith, C, Bekele, E, Tarekegn, A, Thomas, MG, Bradman, N, and Hellenthal, G
- Abstract
The Ari peoples of Ethiopia are comprised of different occupational groups that can be distinguished genetically, with Ari Cultivators and the socially marginalised Ari Blacksmiths recently shown to have a similar level of genetic differentiation between them (FST ≈ 0.023 - 0.04) as that observed among multiple ethnic groups sampled throughout Ethiopia. Anthropologists have proposed two competing theories to explain the origins of the Ari Blacksmiths as (i) remnants of a population that inhabited Ethiopia prior to the arrival of agriculturists (e.g. Cultivators), or (ii) relatively recently related to the Cultivators but presently marginalized in the community due to their trade. Two recent studies by different groups analysed genome-wide DNA from samples of Ari Blacksmiths and Cultivators and suggested that genetic patterns between the two groups were more consistent with model (i) and subsequent assimilation of the indigenous peoples into the expanding agriculturalist community. We analysed the same samples using approaches designed to attenuate signals of genetic differentiation that are attributable to allelic drift within a population. By doing so, we provide evidence that the genetic differences between Ari Blacksmiths and Cultivators can be entirely explained by bottleneck effects consistent with hypothesis (ii). This finding serves as both a cautionary tale about interpreting results from unsupervised clustering algorithms, and suggests that social constructions are contributing directly to genetic differentiation over a relatively short time period among previously genetically similar groups.
- Published
- 2015
14. The Cost-Effectiveness Of Bariatric Surgery In Germany
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Belarbi, S, primary, Kusel, J, additional, Maruszczak, M, additional, Slater, D, additional, Thomas, MG, additional, and Martini, O, additional
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- 2015
- Full Text
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15. Ancient urbanization predicts genetic resistance to tuberculosis
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Barnes, I, Duda, A, Pybus, O, and Thomas, MG
- Abstract
A link between urban living and disease is seen in recent and historical records, but the presence of this association in prehistory has been difficult to assess. If the transition to urban living does result in an increase in disease-based mortality, we might expect to see evidence of increased disease resistance in longer-term urbanized populations, as the result of natural selection. To test this, we determined the frequency of an allele (SLC11A1 1729 + 55del4) associated with natural resistance to intracellular pathogens such as tuberculosis and leprosy. We found a highly significantly correlation with duration of urban settlement-populations with a long history of living in towns are better adapted to resisting these infections. This correlation remains strong when we correct for autocorrelation in allele frequencies due to shared population history. Our results therefore support the interpretation that infectious disease loads became an increasingly important cause of human mortality after the advent of urbanization, highlighting the importance of population density in determining human health and the genetic structure of human populations.
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- 2011
16. Brief Report: AIP Mutation in Pituitary Adenomas in the 18th Century and Today
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Chahal, H, Stals, K, Unterlander, M, Balding, D, Thomas, MG, Kumar, A, Besser, G, Atkinson, AB, Morrison, P, Howlett, T, Levy, M, Orme, S, Akker, SA, Abel, R, Grossman, AB, Burger, J, Ellard, S, and Korbonits, M
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- 2011
17. The development of a colorectal cancer surgery core outcome set
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McNair, AGK, primary, Whistance, RN, additional, Forsythe, RO, additional, Macefield, R, additional, Rees, J, additional, Jones, JE, additional, Smith, G, additional, Pullyblank, AM, additional, Avery, KNL, additional, Brookes, ST, additional, Thomas, MG, additional, Sylvester, PA, additional, Russell, A, additional, Oliver, A, additional, Morton, D, additional, Kennedy, R, additional, Jayne, DG, additional, Huxtable, R, additional, Hackett, R, additional, Dutton, S, additional, Coleman, MG, additional, Card, M, additional, Brown, J, additional, and Blazeby, JM, additional
- Published
- 2015
- Full Text
- View/download PDF
18. Identification of the remains of King Richard III
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King, TE, Gonzalez Fortes, G, Balaresque, P, Thomas, MG, Balding, D, Delser, PM, Neumann, R, Parson, W, Knapp, M, Walsh, S, Tonasso, L, Holt, J, Kayser, M, Appleby, J, Forster, P, Ekserdjian, D, Hofreiter, M, Schuerer, K, King, TE, Gonzalez Fortes, G, Balaresque, P, Thomas, MG, Balding, D, Delser, PM, Neumann, R, Parson, W, Knapp, M, Walsh, S, Tonasso, L, Holt, J, Kayser, M, Appleby, J, Forster, P, Ekserdjian, D, Hofreiter, M, and Schuerer, K
- Abstract
In 2012, a skeleton was excavated at the presumed site of the Grey Friars friary in Leicester, the last-known resting place of King Richard III. Archaeological, osteological and radiocarbon dating data were consistent with these being his remains. Here we report DNA analyses of both the skeletal remains and living relatives of Richard III. We find a perfect mitochondrial DNA match between the sequence obtained from the remains and one living relative, and a single-base substitution when compared with a second relative. Y-chromosome haplotypes from male-line relatives and the remains do not match, which could be attributed to a false-paternity event occurring in any of the intervening generations. DNA-predicted hair and eye colour are consistent with Richard's appearance in an early portrait. We calculate likelihood ratios for the non-genetic and genetic data separately, and combined, and conclude that the evidence for the remains being those of Richard III is overwhelming.
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- 2014
19. Storytelling and story testing in domestication
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Gerbault, P, Allaby, RG, Boivin, N, Rudzinski, A, Grimaldi, IM, Pires, JC, Climer Vigueira, C, Dobney, K, Gremillion, KJ, Barton, L, Arroyo-Kalin, M, Purugganan, MD, De Casas, RR, Bollongino, R, Burger, J, Fuller, DQ, Bradley, DG, Balding, DJ, Richerson, PJ, Gilbert, MTP, Larson, G, Thomas, MG, Gerbault, P, Allaby, RG, Boivin, N, Rudzinski, A, Grimaldi, IM, Pires, JC, Climer Vigueira, C, Dobney, K, Gremillion, KJ, Barton, L, Arroyo-Kalin, M, Purugganan, MD, De Casas, RR, Bollongino, R, Burger, J, Fuller, DQ, Bradley, DG, Balding, DJ, Richerson, PJ, Gilbert, MTP, Larson, G, and Thomas, MG
- Abstract
The domestication of plants and animals marks one of the most significant transitions in human, and indeed global, history. Traditionally, study of the domestication process was the exclusive domain of archaeologists and agricultural scientists; today it is an increasingly multidisciplinary enterprise that has come to involve the skills of evolutionary biologists and geneticists. Although the application of new information sources and methodologies has dramatically transformed our ability to study and understand domestication, it has also generated increasingly large and complex datasets, the interpretation of which is not straightforward. In particular, challenges of equifinality, evolutionary variance, and emergence of unexpected or counter-intuitive patterns all face researchers attempting to infer past processes directly from patterns in data. We argue that explicit modeling approaches, drawing upon emerging methodologies in statistics and population genetics, provide a powerful means of addressing these limitations. Modeling also offers an approach to analyzing datasets that avoids conclusions steered by implicit biases, and makes possible the formal integration of different data types. Here we outline some of the modeling approaches most relevant to current problems in domestication research, and demonstrate the ways in which simulation modeling is beginning to reshape our understanding of the domestication process.
- Published
- 2014
20. Current perspectives and the future of domestication studies
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Larson, G, Piperno, DR, Allaby, RG, Purugganan, MD, Andersson, L, Arroyo-Kalin, M, Barton, L, Vigueira, CC, Denham, T, Dobney, K, Doust, AN, Gepts, P, Gilbert, MTP, Gremillion, KJ, Lucas, L, Lukens, L, Marshall, FB, Olsen, KM, Pires, JC, Richerson, PJ, De Casas, RR, Sanjur, OI, Thomas, MG, Fuller, DQ, Larson, G, Piperno, DR, Allaby, RG, Purugganan, MD, Andersson, L, Arroyo-Kalin, M, Barton, L, Vigueira, CC, Denham, T, Dobney, K, Doust, AN, Gepts, P, Gilbert, MTP, Gremillion, KJ, Lucas, L, Lukens, L, Marshall, FB, Olsen, KM, Pires, JC, Richerson, PJ, De Casas, RR, Sanjur, OI, Thomas, MG, and Fuller, DQ
- Abstract
It is difficult to overstate the cultural and biological impacts that the domestication of plants and animals has had on our species. Fundamental questions regarding where, when, and how many times domestication took place have been of primary interest within a wide range of academic disciplines. Within the last two decades, the advent of new archaeological and genetic techniques has revolutionized our understanding of the pattern and process of domestication and agricultural origins that led to our modern way of life. In the spring of 2011, 25 scholars with a central interest in domestication representing the fields of genetics, archaeobotany, zooarchaeology, geoarchaeology, and archaeology met at the National Evolutionary Synthesis Center to discuss recent domestication research progress and identify challenges for the future. In this introduction to the resulting Special Feature, we present the state of the art in the field by discussing what is known about the spatial and temporal patterns of domestication, and controversies surrounding the speed, intentionality, and evolutionary aspects of the domestication process. We then highlight three key challenges for future research. We conclude by arguing that although recent progress has been impressive, the next decade will yield even more substantial insights not only into how domestication took place, but also when and where it did, and where and why it did not.
- Published
- 2014
21. Ankilozan Spondilitli Hastalarda Artmış MEFV Geni Ekson 10 Mutasyon Sıklığı
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WEALE, M, AKAR, SERVET, THOMAS, MG, BİNİCİER, Ö, ÖNEN, FATOŞ, PLASTER, C, BRADMAN, N, BİRLİK, AHMET MERİH, AKKOÇ, NURULLAH, SAVRAN, YUSUF, and SARI, İSMAİL
- Published
- 2008
22. EE3 - The Cost-Effectiveness of Bariatric Surgery in Germany, France, Italy and the United Kingdom
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Belarbi, S, Kusel, J, and Thomas, MG
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- 2016
- Full Text
- View/download PDF
23. Regional population collapse followed initial agriculture booms in mid-Holocene Europe
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Shennan, S, Downey, SS, Timpson, A, Edinborough, K, Colledge, S, Kerig, T, Manning, K, Thomas, MG, Shennan, S, Downey, SS, Timpson, A, Edinborough, K, Colledge, S, Kerig, T, Manning, K, and Thomas, MG
- Abstract
Following its initial arrival in SE Europe 8,500 years ago agriculture spread throughout the continent, changing food production and consumption patterns and increasing population densities. Here we show that, in contrast to the steady population growth usually assumed, the introduction of agriculture into Europe was followed by a boom-and-bust pattern in the density of regional populations. We demonstrate that summed calibrated radiocarbon date distributions and simulation can be used to test the significance of these demographic booms and busts in the context of uncertainty in the radiocarbon date calibration curve and archaeological sampling. We report these results for Central and Northwest Europe between 8,000 and 4,000 cal. BP and investigate the relationship between these patterns and climate. However, we find no evidence to support a relationship. Our results thus suggest that the demographic patterns may have arisen from endogenous causes, although this remains speculative.
- Published
- 2013
24. Incidence, trends and demographics of Staphylococcus aureus infections in Auckland, New Zealand, 2001-2011
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Williamson, DA, Lim, A, Thomas, MG, Baker, MG, Roberts, SA, Fraser, JD, Ritchie, SR, Williamson, DA, Lim, A, Thomas, MG, Baker, MG, Roberts, SA, Fraser, JD, and Ritchie, SR
- Abstract
BACKGROUND: New Zealand has a higher incidence of Staphylococcus aureus disease than other developed countries, with significant sociodemographic variation in incidence rates. In contrast to North America, the majority of disease is due to methicillin-susceptible S. aureus (MSSA), although relatively little is known about the comparative demographics of MSSA and methicillin-resistant S. aureus (MRSA) infections in New Zealand. METHODS: Our objectives were to describe the trends, incidence and patient demographics of all S. aureus infections in patients presenting to our institution between 2001 and 2011, and compare the epidemiology of MSSA and MRSA infections. We identified all patients with S. aureus infections over the study period. A unique S. aureus infection was defined as the first positive S. aureus culture taken from the same patient within a thirty-day period. Standard definitions were used to classify episodes into community- or healthcare-associated S. aureus infection. RESULTS: There were 16,249 S. aureus infections over the study period. The incidence increased significantly over the study period from 360 to 412 per 100,000 population (P < 0.001), largely driven by an increase in community-associated non-invasive MSSA infections. When compared with MSSA infections, patients with non-multiresistant MRSA infections were more likely to be older, have hospital-onset infections and be Māori or Pacific Peoples. CONCLUSIONS: Our work provides valuable baseline data on the epidemiology and trends of S. aureus infections in New Zealand. The significant increase in community-associated S. aureus infections is of public health importance. Future studies should investigate the reasons underlying this concerning trend.
- Published
- 2013
25. The peopling of Europe and the cautionary tale of Y chromosome lineage R-M269
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Busby, Gbj, Brisighelli, Francesca, Sanchez Diz, P, Ramos Luis, E, Martinez Cadenas, C, Thomas, Mg, Bradley, Dg, Gusmao, L, Winney, B, Bodmer, W, Vennemann, M, Coia, V, Scarnicci, F, Tofanelli, S, Vona, G, Ploski, R, Vecchiotti, C, Zemunik, T, Rudan, I, Karachanak, S, Toncheva, D, Anagnostou, P, Ferri, G, Rapone, C, Hervig, T, Moen, T, Wilson, Jf, Capelli, C., Brisighelli, Francesca (ORCID:0000-0001-5469-4413), Busby, Gbj, Brisighelli, Francesca, Sanchez Diz, P, Ramos Luis, E, Martinez Cadenas, C, Thomas, Mg, Bradley, Dg, Gusmao, L, Winney, B, Bodmer, W, Vennemann, M, Coia, V, Scarnicci, F, Tofanelli, S, Vona, G, Ploski, R, Vecchiotti, C, Zemunik, T, Rudan, I, Karachanak, S, Toncheva, D, Anagnostou, P, Ferri, G, Rapone, C, Hervig, T, Moen, T, Wilson, Jf, Capelli, C., and Brisighelli, Francesca (ORCID:0000-0001-5469-4413)
- Abstract
Recently, the debate on the origins of the major European Y chromosome haplogroup R1b1b2-M269 has reignited, and opinion has moved away from Palaeolithic origins to the notion of a younger Neolithic spread of these chromosomes from the Near East. Here, we address this debate by investigating frequency patterns and diversity in the largest collection of R1b1b2-M269 chromosomes yet assembled. Our analysis reveals no geographical trends in diversity, in contradiction to expectation under the Neolithic hypothesis, and suggests an alternative explanation for the apparent cline in diversity recently described. We further investigate the young, STR-based time to the most recent common ancestor estimates proposed so far for R-M269-related lineages and find evidence for an appreciable effect of microsatellite choice on age estimates. As a consequence, the existing data and tools are insufficient to make credible estimates for the age of this haplogroup, and conclusions about the timing of its origin and dispersal should be viewed with a large degree of caution
- Published
- 2011
26. Schizophrenia susceptibility loci on chromosomes 13q32 and 8p21
- Author
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Blouin, JL Dombroski, BA Nath, SK Lasseter, VK Wolyniec, PS Nestadt, G Thornquist, M Ullrich, G McGrath, J and Kasch, L Lamacz, M Thomas, MG Gehrig, C Radhakrishna, U and Snyder, SE Balk, KG Neufeld, K Swartz, KL DeMarchi, N Papadimitriou, GN Dikeos, DG Stefanis, CN Chakravarti, A Childs, B Housman, DE Kazazian, HH Antonarakis, SE and Pulver, AE
- Abstract
Schizophrenia is a common disorder characterized by psychotic symptoms; diagnostic criteria have been established(1). Family, twin and adoption studies suggest that both genetic and environmental factors influence susceptibility (heritability is approximately 71%; ref. 2), however, little is known about the aetiology of schizophrenia. Clinical and family studies suggest aetiological heterogeneity(3-6). Previously, we reported that regions on chromosomes 22, 3 and 8 may be associated with susceptibility to schizophrenia(7-8), and collaborations provided some support for regions on chromosomes 8 and 22 (refs 9-13). We present here a genome-wide scan for schizophrenia susceptibility loci (SSL) using 452 microsatellite markers on 54 multiplex pedigrees. Non-parametric linkage (NPL) analysis provided significant evidence for an SSL on chromosome 13q32 (NPL score=4.18; P=0.00002), and suggestive evidence for another SSL on chromosome 8p21-22 (NPL=3.64; P=0.0001). Parametric linkage analysis provided additional support for these SSL. Linkage evidence at chromosome 8 is weaker than that at chromosome 13, so it is more probable that chromosome 8 may be a false positive linkage. Additional putative SSL were noted on chromosomes 14q13 (NPL=2.57: P=0.005), 7q11 (NPL=2.50, P=0.007) and 22q11 (NPL=2.42, P=0.009). Verification of suggestive SSL on chromosomes 13q and 8p was attempted in a follow-up sample of 54 multiplex pedigrees. This analysis confirmed the SSL in 13q14-q33 (NPL=2.36, P=0.007) and supported the SSL in 8p22-p21 (NPL=1.95, P=0.023).
- Published
- 1998
27. PCV111 - The Cost-Effectiveness Of Bariatric Surgery In Germany
- Author
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Belarbi, S, Kusel, J, Maruszczak, M, Slater, D, Thomas, MG, and Martini, O
- Published
- 2015
- Full Text
- View/download PDF
28. Reading strategies in nystagmus
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THOMAS, MG, primary, PROUDLOCK, FA, additional, MCLEAN, RJ, additional, and GOTTLOB, I, additional
- Published
- 2008
- Full Text
- View/download PDF
29. Critical Role of Inelastic Interactions in Quantitative Electron Microscopy
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Mkhoyan, KA, primary, Maccagnano-Zacher, SE, additional, Thomas, MG, additional, and Silcox, J, additional
- Published
- 2008
- Full Text
- View/download PDF
30. Pulmonary staging in colorectal cancer – is computerised tomography the answer?
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McIntosh, J, primary, Sylvester, PA, additional, Virjee, J, additional, Callaway, M, additional, and Thomas, MG, additional
- Published
- 2005
- Full Text
- View/download PDF
31. Intentional and unintentional nonadherence in patients prescribed HAART treatment regimens
- Author
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Wroe, AL, primary and Thomas, MG, additional
- Published
- 2003
- Full Text
- View/download PDF
32. Hepatitis B virus variants with core gene deletions in the evolution of chronic hepatitis B infection
- Author
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Marinos, G, primary, Torre, F, additional, Gunther, S, additional, Thomas, MG, additional, Will, H, additional, Williams, R, additional, and Naoumov, NV, additional
- Published
- 1996
- Full Text
- View/download PDF
33. Effects of massage on antibody responses after hepatitis B vaccination.
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Loft P, Petrie KJ, Booth RJ, Thomas MG, Robinson E, and Vedhara K
- Published
- 2012
- Full Text
- View/download PDF
34. Bone marrow stromal cells as replacement cells for Parkinson's disease: generation of an anatomical but not functional neuronal phenotype.
- Author
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Thomas MG, Stone L, Evill L, Ong S, Ziman M, and Hool L
- Abstract
The focus of cell replacement therapies (CRTs) for Parkinson's disease has been on delivering dopamine-producing cells to the striatum. Fetal grafts have proven the feasibility of this approach, but an appropriate source of replacement cells has restricted the clinical translation. Bone marrow stromal cells (BMSCs) have been heralded as an ideal source of dopaminergic (DAergic) replacement cells, as they are viewed as ethically acceptable, easily procured, and readily expanded. It is known that they confer functional benefits, particularly in stroke models, through the release of neurotrophic factors, but their transdifferentiation into neurons is still under contention. We sought to evaluate the neuronal phenotype and functional capacity of adult rat BMSCs after exposure to a novel multistep in vitro differentiation protocol compared with cells exposed to other reported neuronal differentiation conditions. We employed a systematic, comprehensive method of assessment to determine the neuronal differentiation capacity of BMSCs. Our fluorescence-activated cell sorting, immunofluorescent and semiquantitative polymerase chain reaction results confirmed that undifferentiated BMSCs isolated based on their adherence to plastic are of mesenchymal origin and express a range of lineage markers. After exposure to preinduction and neuronal induction steps, BMSCs down-regulate markers of other lineages but fail, as assessed by patch clamp, to differentiate into functional neurons. Thus, for BMSCs to be considered a source of DAergic neuronal replacement cells, their ability to transdifferentiate terminally along a neuronal lineage first must be clarified before attempting to direct more complex specification process required for them to be used in Parkinson's-disease-focused CRTs. [ABSTRACT FROM AUTHOR]
- Published
- 2011
- Full Text
- View/download PDF
35. Team learning: preparing for pandemic flu.
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Thomas MG
- Published
- 2006
36. Team learning: access to health records.
- Author
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Thomas MG
- Published
- 2006
37. Team learning: the appointments system.
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Thomas MG
- Published
- 2006
38. Team learning: child protection and the primary healthcare team.
- Author
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Thomas MG
- Published
- 2005
39. Team learning: coping with stress.
- Author
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Thomas MG
- Published
- 2005
40. Cannula-associated Staphylococcus aureus bacteraemia: outcome in relation to treatment.
- Author
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Thomas MG and Morris AJ
- Published
- 2005
- Full Text
- View/download PDF
41. Team learning: audit in general practice.
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Thomas MG and Turner S
- Published
- 2004
42. Effect of written emotional expression on immune function in patients with human immunodeficiency virus infection: a randomized trial.
- Author
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Petrie KJ, Fontanilla I, Thomas MG, Booth RJ, Pennebaker JW, Petrie, Keith J, Fontanilla, Iris, Thomas, Mark G, Booth, Roger J, and Pennebaker, James W
- Published
- 2004
- Full Text
- View/download PDF
43. Responses of Commercial Broiler Chicks to Acute Gamma Radiation Stress in the Range of 900–1600 R
- Author
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Brisbin Il and Thomas Mg
- Subjects
Analysis of Variance ,Veterinary medicine ,animal structures ,Body Weight ,Broiler ,General Medicine ,Biology ,Radiation Injuries, Experimental ,Vitamin supplement ,Stress, Physiological ,Animals ,Animal Science and Zoology ,Chickens ,Poultry Diseases - Abstract
ALTHOUGH the various strains of broiler chickens are among the most commercially valuable breeds of poultry, the radiatiation responses of these birds have only recently come under study (Brisbin, 1969). Preliminary data reported by Brisbin (1969) have suggested that chicks of a commercial broiler strain had an unusually high degree of resistance to gamma radiation stress. These chicks showed no mortality following exposures to total doses as high as 900 R, administered at the rate of 8 R/min. at an age of two days, although other breeds of chickens have been reported to show up to 50% mortality following exposures to doses as low as 800 R, administered under similar conditions (Steamer, 1951; Tyler and Steamer, 1962; Mraz, 1968). In previous studies, all chicks were routinely given an antibiotic and vitamin supplement (Vita-lizer—Vineland Poultry Laboratories) for the first nine days following exposure, and it is possible that this supplement…
- Published
- 1971
44. Mexiletine: long-term follow-up of a patient with prolonged QT interval and quinidine-induced torsades de pointes
- Author
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Giles Td and Thomas Mg
- Subjects
Quinidine ,Male ,medicine.medical_specialty ,Lidocaine ,Long term follow up ,Torsades de pointes ,Mexiletine ,Ventricular tachycardia ,QT interval ,Electrocardiography ,Internal medicine ,Tachycardia ,medicine ,Humans ,In patient ,Propylamines ,business.industry ,General Medicine ,Middle Aged ,medicine.disease ,Long-Term Care ,Cardiology ,business ,medicine.drug ,Follow-Up Studies - Abstract
The use of class 1A antidysrhythmic agents in patients with or without prolonged QT intervals carries a risk of induction of polymorphic ventricular tachycardia. The class 1B antidysrhythmics have many similarities to the former group, but have different modes of action and electrophysiologic properties. Therefore, lidocaine and lidocaine-like drugs such as mexiletine may be used with relative safety in this clinical situation, as in the case we have reported, in which lidocaine and mexiletine controlled VPB in the acute stage and during long-term follow-up respectively, while quinidine induced "torsades de pointes."
- Published
- 1985
45. Acalculous cholecystitis complicating hepatic intraarterial lipiodol: case report
- Author
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I.S. Benjamin, Jackson J, Thomas Mg, Finn Jp, Adam A, and E Y Yeung
- Subjects
medicine.medical_specialty ,medicine.medical_treatment ,Computed tomography ,Diagnostic accuracy ,Necrosis ,Laparotomy ,medicine ,Cholecystitis ,Edema ,Humans ,Radiology, Nuclear Medicine and imaging ,medicine.diagnostic_test ,business.industry ,Liver Diseases ,Liver Neoplasms ,Angiography ,Acalculous cholecystitis ,Iodized Oil ,Middle Aged ,medicine.disease ,Surgery ,Injections, Intra-Arterial ,Lipiodol ,Female ,Radiology ,Cardiology and Cardiovascular Medicine ,Complication ,business ,Tomography, X-Ray Computed ,medicine.drug - Abstract
Hepatic intraarterial injection of Lipiodol has been used by various authors to enhance the diagnostic accuracy of computed tomography in hepatic tumors. The technique appears safe and seems free from serious complications when used judiciously. We report a case in which injection of hepatic intraarterial Lipiodol precipitated acalculous cholecystitis requiring urgent laparotomy.
- Published
- 1989
46. OC-057 Undetectable faecal immunochemical test for haemoglobin excludes colorectal cancer in symptomatic patients: a prospective uk study
- Author
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Widlak, MM, Thomas, CL, Thomas, MG, Tomkins, C, Smith, S, Darby, C, O’Connell, N, Wurie, S, Burns, L, Harmston, C, Evans, C, Nwokolo, CU, Singh, B, and Arasaradnam, RP
- Abstract
IntroductionThe diagnosis of colorectal cancer (CRC) in primary care can be challenging as symptoms are variable with poor specificity. We investigated the diagnostic accuracies of faecal immunochemical test for haemoglobin (FIT) and faecal calprotectin (FCP) in symptomatic patients referred from primary care for urgent lower gastrointestinal investigations via the two-week wait colorectal pathway.Method1016 patients were prospectively recruited between January 2015 and September 2016. In total 612 patients returned stool samples, completed colonic investigations and were included in the final statistical analysis (51% women, median age 68 years, IQR: 57–76). FIT was performed on HM-JACKarc analyser (Kyowa Medex), and FCP by EliA Calprotectin immunoassay (Thermo Fisher Scientific). Any detectable FIT (detection limit 7 µg Hb/g faeces) and a cut-off of 50 µg/g for FCP were considered positive.Results37 (6%) patients were diagnosed with CRC. The negative predictive value (NPV) of FIT vs. FIT plus FCP was the same at 99% (95% CI 98% to 100%). The sensitivity and specificity of FIT was 84% and 89%, respectively. Whereas, it was 89% and 86% for FIT combined with FCP. The ROCs for FIT, FCP and both faecal biomarkers combined showed AUC 0.90, 0.73 and 0.91, respectively. Faecal ćhaemoglobin measurements were significantly higher in left-sided colonic lesions compared ćwith the right side; 490 µg Hb/g faeces vs. 90 µg Hb/g faeces; p=0.007).[Figure]ConclusionUndetectable FIT is sufficiently sensitive to exclude colorectal cancer, with higher values in left-sided lesions. FCP in combination does not appear to provide additional diagnostic information. Further studies to determine the health economic benefits of implementing FIT in primary care are required.Disclosure of InterestM. Widlak: None Declared, C. Thomas: None Declared, M. Thomas: None Declared, C. Tomkins Conflict with: Educational lectures on behalf of Thermo Fisher Scientific Ltd., S. Smith: None Declared, C. Darby: None Declared, N. O’Connell: None Declared, S. Wurie: None Declared, L. Burns: None Declared, C. Harmston: None Declared, C. Evans: None Declared, C. Nwokolo: None Declared, B. Singh: None Declared, R. Arasaradnam Conflict with: Educational lectures on behalf of Thermo Fisher Scientific Ltd.
- Published
- 2017
- Full Text
- View/download PDF
47. PCV111 The Cost-Effectiveness Of Bariatric Surgery In Germany
- Author
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Belarbi, S, Kusel, J, Maruszczak, M, Slater, D, Thomas, MG, and Martini, O
- Full Text
- View/download PDF
48. Ancient human genomes suggest three ancestral populations for present-day Europeans
- Author
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Joanna L. Mountain, Michael F. Hammer, Ruslan Ruizbakiev, Cesare de Filippo, Kumarasamy Thangaraj, David E. C. Cole, Haim Ben-Ami, Leila Laredj, Mark Lipson, Jüri Parik, Valentino Romano, Andres Ruiz-Linares, Fouad Berrada, Dominique Delsate, Ugur Hodoglugil, Antti Sajantila, Olga Utevska, Shahlo Turdikulova, Tor Hervig, Ludmila P. Osipova, Hovhannes Sahakyan, Robert W. Mahley, Ramiro Barrantes, Kirsten I. Bos, Stanislav Dryomov, Peter H. Sudmant, Nadin Rohland, Heng Li, Gabriel Renaud, Mikhail Voevoda, Claudio M. Bravi, Jean-Michel Guinet, Rem I. Sukernik, Joachim Wahl, Matthias Meyer, Christos Economou, Kay Prüfer, Graciela Bailliet, Mait Metspalu, Mikhail Churnosov, Iosif Lazaridis, Johannes Krause, Bonnie Berger, Levon Yepiskoposyan, Francesca Brisighelli, Francesco Calì, Irene Gallego Romero, Oleg Balanovsky, George Ayodo, Alan Cooper, Alissa Mittnik, Julio Molina, George van Driem, Jean-Michel Dugoujon, Larissa Damba, Fedor Platonov, Nick Patterson, David Reich, Thomas B. Nyambo, David Comas, Olga L. Posukh, Béla Melegh, Draga Toncheva, Alena Kushniarevich, Brenna M. Henn, Montgomery Slatkin, René Vasquez, Elena B. Starikovskaya, Joachim Burger, Ayele Tarekegn, Tatijana Zemunik, Ene Metspalu, Sena Karachanak-Yankova, Lalji Singh, Wolfgang Haak, Susanna Sawyer, Rick A. Kittles, Cheryl A. Winkler, Svante Pääbo, Francisco Rothhammer, Marina Gubina, Pierre Zalloua, Aashish R. Jha, Swapan Mallick, Sergi Castellano, Qiaomei Fu, Desislava Nesheva, Sergey Litvinov, Ingrida Uktveryte, Michael Francken, Cosimo Posth, Theologos Loukidis, Cristian Capelli, Janet Kelso, Sarah A. Tishkoff, Toomas Kivisild, Mark G. Thomas, Elin Fornander, Mercedes Villena, Fredrik Hallgren, Vaidutis Kučinskas, Daniel Corach, George B.J. Busby, Judit Bene, William Klitz, Hamza A. Babiker, Karola Kirsanow, Ruth Bollongino, Rita Khusainova, Evan E. Eichler, Sardana A. Fedorova, Klemetti Näkkäläjärvi, Igor Rudan, Susanne Nordenfelt, Joshua G. Schraiber, Elena Balanovska, Antonio Salas, Richard Villems, Gabriel Bedoya, Elza Khusnutdinova, Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology. Department of Mathematics, Lipson, Mark, Berger Leighton, Bonnie, Lazaridis,I, Patterson,P, Mittnik,A, Renaud,G, Mallick,S, Kirsanow,K, Sudmant,PH, Schraiber,JG, Castellano,S, Lipson,M, Berger,B, Economou,C, Bollongino,R, Fu,Q, Bos,KI, Nordenfelt,S, Li,H, De Filippo,C, Pruefer,K, Sawyer, Posth,C, Haak1,H, Hallgren,F, Fornander,E, Rohland,N, Delsate,D, Francken,M, Guinet,JM, Wah,J, Ayodo,G, Babiker,HA, Bailliet,G, Balanovska,E, Balanovsky,O, Barrantes,R, Bedoya,G, Ben-Ami,H, Bene,J, Berrada,F, Bravi,CM, Brisighelli,F, Busby,GBJ, Cali,F, Churnosov,M, Cole,DEC, Corach,D, Damba,L, van Driem,G, Dryomov,S, Dugoujon,JM, Fedorova,SA, Gallego Romero,I, Gubina,M, Hammer,M, Henn,BM, Hervig,T, Hodoglugi,U, Jha,AR, Karachanak-Yankova,S, Khusainova,R, Khusnutdinova,E, Kittles,R:Kivisild,T, Klitz,W, Kucˇinskas,V, Kushniarevich,A, Laredj,L, Litvinov,S, Loukidis,T, Mahley,RW, Melegh,B, Metspalu,E, Molina,J, Mountain,J, Na¨kka¨la¨ja¨rvi,K, Nesheva,D, Nyambo,T, Osipova,L, Parik,J, Platonov,F, Posukh,O, Romano,V, Rothhammer,F, Rudan,I, Ruizbakiev,R, Sahakyan,H, Sajantila,A, Salas,A, Starikovskaya,EB, Tarekegn,A, Toncheva,D, Turdikulova,S, Uktveryte,I, Utevska,O, Vasquez,R, Villena,M, Voevoda,M, Winkler,CA, Yepiskoposyan,L, Zalloua,P, Zemunik,T, Cooper, Capelli,C, Thomas,MG, Ruiz-inares,A, Tishkoff,SA, Singh,L, Thangaraj,K, Villems,R, Comas,D, Sukernik,R, Metspalu,M, Meyer,M, Eichler,EE, Burger,J, Slatkin,M, Pa¨a¨bo,S, Kelso,J, Reich,D, and Krause,J
- Subjects
History ,Neanderthal ,Biología ,Population Dynamics ,Present day ,Genoma humà ,Genome ,purl.org/becyt/ford/1 [https] ,Basal (phylogenetics) ,Settore BIO/13 - Biologia Applicata ,History, Ancient ,Genetics ,Principal Component Analysis ,education.field_of_study ,0303 health sciences ,Multidisciplinary ,Ancient DNA ,030305 genetics & heredity ,food and beverages ,Agriculture ,Genomics ,3. Good health ,Europe ,Workforce ,CIENCIAS NATURALES Y EXACTAS ,Human ,Archaeogenetics ,Asia ,Lineage (genetic) ,EUROPE ,Otras Ciencias Biológicas ,European Continental Ancestry Group ,Population ,Settore BIO/08 - ANTROPOLOGIA ,evolution ,Europeans ,Biology ,Article ,White People ,Ancient ,Genètica de poblacions humanes ,Human origins ,Ciencias Biológicas ,03 medical and health sciences ,HUMAN ORIGINS ,biology.animal ,Humans ,ANCIENT DNA ,purl.org/becyt/ford/1.6 [https] ,education ,Quantitative Biology - Populations and Evolution ,Denisovan ,030304 developmental biology ,Genetic diversity ,ancient DNA, modern DNA, Europeans, prehistory ,Genome, Human ,Populations and Evolution (q-bio.PE) ,biology.organism_classification ,Evolutionary biology ,FOS: Biological sciences ,Upper Paleolithic ,Human genome ,GENOMICS - Abstract
We sequenced the genomes of a ∼7,000-year-old farmer from Germany and eight ∼8,000-year-old hunter-gatherers from Luxembourg and Sweden. We analysed these and other ancient genomes1,2,3,4 with 2,345 contemporary humans to show that most present-day Europeans derive from at least three highly differentiated populations: west European hunter-gatherers, who contributed ancestry to all Europeans but not to Near Easterners; ancient north Eurasians related to Upper Palaeolithic Siberians3, who contributed to both Europeans and Near Easterners; and early European farmers, who were mainly of Near Eastern origin but also harboured west European hunter-gatherer related ancestry. We model these populations’ deep relationships and show that early European farmers had ∼44% ancestry from a ‘basal Eurasian’ population that split before the diversification of other non-African lineages., Instituto Multidisciplinario de Biología Celular
- Published
- 2014
49. Population structure in the Méditerranean basin: a Y chromosome perspective
- Author
-
Alex E. Felice, Andrea Novelletto, A. Berebbi, Vincenzo Lorenzo Pascali, Valérie Delague, André Mégarbané, David Goldstein, Pavlos Neophytou, Nicola Redhead, Gérard Lefranc, Patrizia Malaspina, Marc Fellous, L. Terrenato, Mark G. Thomas, Valentino Romano, Cristian Capelli, Z. Poulli, Filippo Cali, Institut de génétique humaine (IGH), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), CAPELLI C, REDHEAD N, ROMANO V, CALI F, LEFRANC G, DELAGUE G, MEGARBANE A, FELICE AE, PASCALI AV, NEOPHYTOU PI, POULLI Z, NOVELLETTO A, MALASPINA P, TERRENATO L, BEREBBI A, FELLOUS M, THOMAS MG, and AND GOLDSTEIN DB
- Subjects
Mediterranean climate ,Male ,demography ,haplotype ,Southern Europe ,genotype ,UEPs ,Population genetics ,Variation (Genetics) ,Arab ,Mediterranean ,Mediterranean Basin ,article ,cluster analysis ,gene locus ,genetic linkage ,genetic variability ,human ,male ,North Africa ,population genetics ,population structure ,priority journal ,Y chromosome, Chromosomes, Human, Y ,Ethnic Groups ,Genetics, Population ,Humans ,Mediterranean Region ,Ethnicity ,[SDV.BDD]Life Sciences [q-bio]/Development Biology ,Genetics (clinical) ,Genetics ,0303 health sciences ,education.field_of_study ,Ecology ,030305 genetics & heredity ,Population genetic structure ,STRs ,Y chromosome ,Y-chromosome, population genetics, Arab ,Population ,Biology ,Chromosomes ,03 medical and health sciences ,Genetic variation ,Genetic variability ,education ,030304 developmental biology ,[SDV.GEN]Life Sciences [q-bio]/Genetics ,Chromosomes, Human, Y ,Haplotype ,Genetic Variation ,Settore MED/43 - MEDICINA LEGALE ,Settore BIO/18 - Genetica - Abstract
The Mediterranean region has been characterised by a number of pre-historical and historical demographic events whose legacy on the current genetic landscape is still a matter of debate. In order to investigate the degree of population structure across the Mediterranean, we have investigated Y chromosome variation in a large dataset of Mediterranean populations, 11 of which are first described here. Our analyses identify four main clusters in the Mediterranean that can be labelled as North Africa, Arab, Central-East and West Mediterranean. In particular, Near Eastern samples tend to separate according to the presence of Arab Y chromosome lineages, suggesting that the Arab expansion played a major role in shaping the current genetic structuring within the Fertile Crescent.
- Published
- 2006
50. Improved feasibility of handheld optical coherence tomography in children with craniosynostosis.
- Author
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Rufai SR, Panteli V, Henderson RH, Bunce C, Gottlob I, Thomas MG, Proudlock FA, Bowman R, and Jeelani NUO
- Subjects
- Humans, Male, Infant, Child, Preschool, Female, Child, Tomography, Optical Coherence methods, Craniosynostoses diagnostic imaging, Feasibility Studies
- Published
- 2024
- Full Text
- View/download PDF
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