1,006 results on '"Thomas, Mark G."'
Search Results
2. The Evolution of Lactose Tolerance in Dairying Populations
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Gerbault, Pascale, Walker, Catherine, Yonova-Doing, Ekaterina, Brown, Katherine, Thomas, Mark G., Lee-Thorp, Julia, book editor, and Katzenberg, M. Anne, book editor
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- 2024
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3. Rising antimicrobial resistance : a strong reason to reduce excessive antimicrobial consumption in New Zealand
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Thomas, Mark G., Smith, Alesha J., and Tilyard, Murray W.
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- 2014
4. The Anglo-Saxon migration and the formation of the early English gene pool
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Gretzinger, Joscha, Sayer, Duncan, Justeau, Pierre, Altena, Eveline, Pala, Maria, Dulias, Katharina, Edwards, Ceiridwen J., Jodoin, Susanne, Lacher, Laura, Sabin, Susanna, Vågene, Åshild J., Haak, Wolfgang, Ebenesersdóttir, S. Sunna, Moore, Kristjan H. S., Radzeviciute, Rita, Schmidt, Kara, Brace, Selina, Bager, Martina Abenhus, Patterson, Nick, Papac, Luka, Broomandkhoshbacht, Nasreen, Callan, Kimberly, Harney, Éadaoin, Iliev, Lora, Lawson, Ann Marie, Michel, Megan, Stewardson, Kristin, Zalzala, Fatma, Rohland, Nadin, Kappelhoff-Beckmann, Stefanie, Both, Frank, Winger, Daniel, Neumann, Daniel, Saalow, Lars, Krabath, Stefan, Beckett, Sophie, Van Twest, Melanie, Faulkner, Neil, Read, Chris, Barton, Tabatha, Caruth, Joanna, Hines, John, Krause-Kyora, Ben, Warnke, Ursula, Schuenemann, Verena J., Barnes, Ian, Dahlström, Hanna, Clausen, Jane Jark, Richardson, Andrew, Popescu, Elizabeth, Dodwell, Natasha, Ladd, Stuart, Phillips, Tom, Mortimer, Richard, Sayer, Faye, Swales, Diana, Stewart, Allison, Powlesland, Dominic, Kenyon, Robert, Ladle, Lilian, Peek, Christina, Grefen-Peters, Silke, Ponce, Paola, Daniels, Robin, Spall, Cecily, Woolcock, Jennifer, Jones, Andy M., Roberts, Amy V., Symmons, Robert, Rawden, Anooshka C., Cooper, Alan, Bos, Kirsten I., Booth, Tom, Schroeder, Hannes, Thomas, Mark G., Helgason, Agnar, Richards, Martin B., Reich, David, Krause, Johannes, and Schiffels, Stephan
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- 2022
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5. Dairying, diseases and the evolution of lactase persistence in Europe
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Evershed, Richard P., Davey Smith, George, Roffet-Salque, Mélanie, Timpson, Adrian, Diekmann, Yoan, Lyon, Matthew S., Cramp, Lucy J. E., Casanova, Emmanuelle, Smyth, Jessica, Whelton, Helen L., Dunne, Julie, Brychova, Veronika, Šoberl, Lucija, Gerbault, Pascale, Gillis, Rosalind E., Heyd, Volker, Johnson, Emily, Kendall, Iain, Manning, Katie, Marciniak, Arkadiusz, Outram, Alan K., Vigne, Jean-Denis, Shennan, Stephen, Bevan, Andrew, Colledge, Sue, Allason-Jones, Lyndsay, Amkreutz, Luc, Anders, Alexandra, Arbogast, Rose-Marie, Bălăşescu, Adrian, Bánffy, Eszter, Barclay, Alistair, Behrens, Anja, Bogucki, Peter, Carrancho Alonso, Ángel, Carretero, José Miguel, Cavanagh, Nigel, Claßen, Erich, Collado Giraldo, Hipolito, Conrad, Matthias, Csengeri, Piroska, Czerniak, Lech, Dębiec, Maciej, Denaire, Anthony, Domboróczki, László, Donald, Christina, Ebert, Julia, Evans, Christopher, Francés-Negro, Marta, Gronenborn, Detlef, Haack, Fabian, Halle, Matthias, Hamon, Caroline, Hülshoff, Roman, Ilett, Michael, Iriarte, Eneko, Jakucs, János, Jeunesse, Christian, Johnson, Melanie, Jones, Andy M., Karul, Necmi, Kiosak, Dmytro, Kotova, Nadezhda, Krause, Rüdiger, Kretschmer, Saskia, Krüger, Marta, Lefranc, Philippe, Lelong, Olivia, Lenneis, Eva, Logvin, Andrey, Lüth, Friedrich, Marton, Tibor, Marley, Jane, Mortimer, Richard, Oosterbeek, Luiz, Oross, Krisztián, Pavúk, Juraj, Pechtl, Joachim, Pétrequin, Pierre, Pollard, Joshua, Pollard, Richard, Powlesland, Dominic, Pyzel, Joanna, Raczky, Pál, Richardson, Andrew, Rowe, Peter, Rowland, Stephen, Rowlandson, Ian, Saile, Thomas, Sebők, Katalin, Schier, Wolfram, Schmalfuß, Germo, Sharapova, Svetlana, Sharp, Helen, Sheridan, Alison, Shevnina, Irina, Sobkowiak-Tabaka, Iwona, Stadler, Peter, Stäuble, Harald, Stobbe, Astrid, Stojanovski, Darko, Tasić, Nenad, van Wijk, Ivo, Vostrovská, Ivana, Vuković, Jasna, Wolfram, Sabine, Zeeb-Lanz, Andrea, and Thomas, Mark G.
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- 2022
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6. Benchmarking of human Y-chromosomal haplogroup classifiers with whole-genome and whole-exome sequence data
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García-Olivares, Víctor, Muñoz-Barrera, Adrián, Rubio-Rodríguez, Luis A., Jáspez, David, Díaz-de Usera, Ana, Iñigo-Campos, Antonio, Veeramah, Krishna R., Alonso, Santos, Thomas, Mark G., Lorenzo-Salazar, José M., González-Montelongo, Rafaela, and Flores, Carlos
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- 2023
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7. North Pontic crossroads: Mobility in Ukraine from the Bronze Age to the early modern period
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Saag, Lehti, primary, Utevska, Olga, additional, Zadnikov, Stanislav, additional, Shramko, Iryna, additional, Gorbenko, Kyrylo, additional, Bandrivskyi, Mykola, additional, Pavliv, Dmytro, additional, Bruyako, Igor, additional, Grechko, Denys, additional, Okatenko, Vitalii, additional, Toshev, Gennadi, additional, Andrukh, Svitlana, additional, Radziyevska, Vira, additional, Buynov, Yurii, additional, Kotenko, Viktoriia, additional, Smyrnov, Oleksandr, additional, Petrauskas, Oleg, additional, Magomedov, Borys, additional, Didenko, Serhii, additional, Heiko, Anatolii, additional, Reida, Roman, additional, Sapiehin, Serhii, additional, Aksonov, Viktor, additional, Laptiev, Oleksii, additional, Terskyi, Svyatoslav, additional, Skorokhod, Viacheslav, additional, Zhyhola, Vitalii, additional, Sytyi, Yurii, additional, Jarve, Mari, additional, Scheib, Christiana Lyn, additional, Anastasiadou, Kyriaki, additional, Kelly, Monica, additional, Williams, Mia, additional, Silva, Marina, additional, Barrington, Christopher, additional, Gilardet, Alexandre, additional, Macleod, Ruairidh, additional, Skoglund, Pontus, additional, and Thomas, Mark G, additional
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- 2024
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8. Large-scale migration into Britain during the Middle to Late Bronze Age
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Patterson, Nick, Isakov, Michael, Booth, Thomas, Büster, Lindsey, Fischer, Claire-Elise, Olalde, Iñigo, Ringbauer, Harald, Akbari, Ali, Cheronet, Olivia, Bleasdale, Madeleine, Adamski, Nicole, Altena, Eveline, Bernardos, Rebecca, Brace, Selina, Broomandkhoshbacht, Nasreen, Callan, Kimberly, Candilio, Francesca, Culleton, Brendan, Curtis, Elizabeth, Demetz, Lea, Carlson, Kellie Sara Duffett, Edwards, Ceiridwen J., Fernandes, Daniel M., Foody, M. George B., Freilich, Suzanne, Goodchild, Helen, Kearns, Aisling, Lawson, Ann Marie, Lazaridis, Iosif, Mah, Matthew, Mallick, Swapan, Mandl, Kirsten, Micco, Adam, Michel, Megan, Morante, Guillermo Bravo, Oppenheimer, Jonas, Özdoğan, Kadir Toykan, Qiu, Lijun, Schattke, Constanze, Stewardson, Kristin, Workman, J. Noah, Zalzala, Fatma, Zhang, Zhao, Agustí, Bibiana, Allen, Tim, Almássy, Katalin, Amkreutz, Luc, Ash, Abigail, Baillif-Ducros, Christèle, Barclay, Alistair, Bartosiewicz, László, Baxter, Katherine, Bernert, Zsolt, Blažek, Jan, Bodružić, Mario, Boissinot, Philippe, Bonsall, Clive, Bradley, Pippa, Brittain, Marcus, Brookes, Alison, Brown, Fraser, Brown, Lisa, Brunning, Richard, Budd, Chelsea, Burmaz, Josip, Canet, Sylvain, Carnicero-Cáceres, Silvia, Čaušević-Bully, Morana, Chamberlain, Andrew, Chauvin, Sébastien, Clough, Sharon, Čondić, Natalija, Coppa, Alfredo, Craig, Oliver, Črešnar, Matija, Cummings, Vicki, Czifra, Szabolcs, Danielisová, Alžběta, Daniels, Robin, Davies, Alex, de Jersey, Philip, Deacon, Jody, Deminger, Csilla, Ditchfield, Peter W., Dizdar, Marko, Dobeš, Miroslav, Dobisíková, Miluše, Domboróczki, László, Drinkall, Gail, Đukić, Ana, Ernée, Michal, Evans, Christopher, Evans, Jane, Fernández-Götz, Manuel, Filipović, Slavica, Fitzpatrick, Andrew, Fokkens, Harry, Fowler, Chris, Fox, Allison, Gallina, Zsolt, Gamble, Michelle, González Morales, Manuel R., González-Rabanal, Borja, Green, Adrian, Gyenesei, Katalin, Habermehl, Diederick, Hajdu, Tamás, Hamilton, Derek, Harris, James, Hayden, Chris, Hendriks, Joep, Hernu, Bénédicte, Hey, Gill, Horňák, Milan, Ilon, Gábor, Istvánovits, Eszter, Jones, Andy M., Kavur, Martina Blečić, Kazek, Kevin, Kenyon, Robert A., Khreisheh, Amal, Kiss, Viktória, Kleijne, Jos, Knight, Mark, Kootker, Lisette M., Kovács, Péter F., Kozubová, Anita, Kulcsár, Gabriella, Kulcsár, Valéria, Le Pennec, Christophe, Legge, Michael, Leivers, Matt, Loe, Louise, López-Costas, Olalla, Lord, Tom, Los, Dženi, Lyall, James, Marín-Arroyo, Ana B., Mason, Philip, Matošević, Damir, Maxted, Andy, McIntyre, Lauren, McKinley, Jacqueline, McSweeney, Kathleen, Meijlink, Bernard, Mende, Balázs G., Menđušić, Marko, Metlička, Milan, Meyer, Sophie, Mihovilić, Kristina, Milasinovic, Lidija, Minnitt, Steve, Moore, Joanna, Morley, Geoff, Mullan, Graham, Musilová, Margaréta, Neil, Benjamin, Nicholls, Rebecca, Novak, Mario, Pala, Maria, Papworth, Martin, Paresys, Cécile, Patten, Ricky, Perkić, Domagoj, Pesti, Krisztina, Petit, Alba, Petriščáková, Katarína, Pichon, Coline, Pickard, Catriona, Pilling, Zoltán, Price, T. Douglas, Radović, Siniša, Redfern, Rebecca, Resutík, Branislav, Rhodes, Daniel T., Richards, Martin B., Roberts, Amy, Roefstra, Jean, Sankot, Pavel, Šefčáková, Alena, Sheridan, Alison, Skae, Sabine, Šmolíková, Miroslava, Somogyi, Krisztina, Somogyvári, Ágnes, Stephens, Mark, Szabó, Géza, Szécsényi-Nagy, Anna, Szeniczey, Tamás, Tabor, Jonathan, Tankó, Károly, Maria, Clenis Tavarez, Terry, Rachel, Teržan, Biba, Teschler-Nicola, Maria, Torres-Martínez, Jesús F., Trapp, Julien, Turle, Ross, Ujvári, Ferenc, van der Heiden, Menno, Veleminsky, Petr, Veselka, Barbara, Vytlačil, Zdeněk, Waddington, Clive, Ware, Paula, Wilkinson, Paul, Wilson, Linda, Wiseman, Rob, Young, Eilidh, Zaninović, Joško, Žitňan, Andrej, Lalueza-Fox, Carles, de Knijff, Peter, Barnes, Ian, Halkon, Peter, Thomas, Mark G., Kennett, Douglas J., Cunliffe, Barry, Lillie, Malcolm, Rohland, Nadin, Pinhasi, Ron, Armit, Ian, and Reich, David
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- 2022
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9. Did Our Species Evolve in Subdivided Populations across Africa, and Why Does It Matter?
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Scerri, Eleanor ML, Thomas, Mark G, Manica, Andrea, Gunz, Philipp, Stock, Jay T, Stringer, Chris, Grove, Matt, Groucutt, Huw S, Timmermann, Axel, Rightmire, G Philip, d’Errico, Francesco, Tryon, Christian A, Drake, Nick A, Brooks, Alison S, Dennell, Robin W, Durbin, Richard, Henn, Brenna M, Lee-Thorp, Julia, deMenocal, Peter, Petraglia, Michael D, Thompson, Jessica C, Scally, Aylwyn, and Chikhi, Lounès
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Biological Sciences ,Ecology ,Africa ,Animals ,Archaeology ,Biological Evolution ,Ecosystem ,Fossils ,Genetics ,Population ,Geography ,Hominidae ,Humans ,African origins ,Middle Stone Age ,evolutionary genetics ,human evolution ,paleoanthropology ,paleoecology ,Environmental Sciences ,Evolutionary Biology ,Biological sciences ,Environmental sciences - Abstract
We challenge the view that our species, Homo sapiens, evolved within a single population and/or region of Africa. The chronology and physical diversity of Pleistocene human fossils suggest that morphologically varied populations pertaining to the H. sapiens clade lived throughout Africa. Similarly, the African archaeological record demonstrates the polycentric origin and persistence of regionally distinct Pleistocene material culture in a variety of paleoecological settings. Genetic studies also indicate that present-day population structure within Africa extends to deep times, paralleling a paleoenvironmental record of shifting and fractured habitable zones. We argue that these fields support an emerging view of a highly structured African prehistory that should be considered in human evolutionary inferences, prompting new interpretations, questions, and interdisciplinary research directions.
- Published
- 2018
10. Synchronous diversification of Sulawesi's iconic artiodactyls driven by recent geological events
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Frantz, Laurent AF, Rudzinski, Anna, Nugraha, Abang Mansyursyah Surya, Evin, Allowen, Burton, James, Hulme-Beaman, Ardern, Linderholm, Anna, Barnett, Ross, Vega, Rodrigo, Irving-Pease, Evan K, Haile, James, Allen, Richard, Leus, Kristin, Shephard, Jill, Hillyer, Mia, Gillemot, Sarah, van den Hurk, Jeroen, Ogle, Sharron, Atofanei, Cristina, Thomas, Mark G, Johansson, Friederike, Mustari, Abdul Haris, Williams, John, Mohamad, Kusdiantoro, Damayanti, Chandramaya Siska, Wiryadi, Ita Djuwita, Obbles, Dagmar, Mona, Stephano, Day, Hally, Yasin, Muhammad, Meker, Stefan, McGuire, Jimmy A, Evans, Ben J, von Rintelen, Thomas, Ho, Simon YW, Searle, Jeremy B, Kitchener, Andrew C, Macdonald, Alastair A, Shaw, Darren J, Hall, Robert, Galbusera, Peter, and Larson, Greger
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Animals ,Base Sequence ,Buffaloes ,DNA ,Mitochondrial ,Genetic Speciation ,Geography ,Geological Phenomena ,Indonesia ,Islands ,Microsatellite Repeats ,Phylogeny ,Phylogeography ,Swine ,biogeography ,evolution ,geology ,Wallacea ,Biological Sciences ,Agricultural and Veterinary Sciences ,Medical and Health Sciences - Abstract
The high degree of endemism on Sulawesi has previously been suggested to have vicariant origins, dating back to 40 Ma. Recent studies, however, suggest that much of Sulawesi's fauna assembled over the last 15 Myr. Here, we test the hypothesis that more recent uplift of previously submerged portions of land on Sulawesi promoted diversification and that much of its faunal assemblage is much younger than the island itself. To do so, we combined palaeogeographical reconstructions with genetic and morphometric datasets derived from Sulawesi's three largest mammals: the babirusa, anoa and Sulawesi warty pig. Our results indicate that although these species most likely colonized the area that is now Sulawesi at different times (14 Ma to 2-3 Ma), they experienced an almost synchronous expansion from the central part of the island. Geological reconstructions indicate that this area was above sea level for most of the last 4 Myr, unlike most parts of the island. We conclude that emergence of land on Sulawesi (approx. 1-2 Myr) may have allowed species to expand synchronously. Altogether, our results indicate that the establishment of the highly endemic faunal assemblage on Sulawesi was driven by geological events over the last few million years.
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- 2018
11. Disentangling Immediate Adaptive Introgression from Selection on Standing Introgressed Variation in Humans
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Jagoda, Evelyn, Lawson, Daniel J, Wall, Jeffrey D, Lambert, David, Muller, Craig, Westaway, Michael, Leavesley, Matthew, Capellini, Terence D, Mirazón Lahr, Marta, Gerbault, Pascale, Thomas, Mark G, Migliano, Andrea Bamberg, Willerslev, Eske, Metspalu, Mait, and Pagani, Luca
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Generic health relevance ,adaptive introgression ,Neanderthal ,positive selection ,archaic genomes ,interferon ,toll-like receptor ,Biochemistry and Cell Biology ,Evolutionary Biology ,Genetics - Abstract
Recent studies have reported evidence suggesting that portions of contemporary human genomes introgressed from archaic hominin populations went to high frequencies due to positive selection. However, no study to date has specifically addressed the postintrogression population dynamics of these putative cases of adaptive introgression. Here, for the first time, we specifically define cases of immediate adaptive introgression (iAI) in which archaic haplotypes rose to high frequencies in humans as a result of a selective sweep that occurred shortly after the introgression event. We define these cases as distinct from instances of selection on standing introgressed variation (SI), in which an introgressed haplotype initially segregated neutrally and subsequently underwent positive selection. Using a geographically diverse data set, we report novel cases of selection on introgressed variation in living humans and shortlist among these cases those whose selective sweeps are more consistent with having been the product of iAI rather than SI. Many of these novel inferred iAI haplotypes have potential biological relevance, including three that contain immune-related genes in West Siberians, South Asians, and West Eurasians. Overall, our results suggest that iAI may not represent the full picture of positive selection on archaically introgressed haplotypes in humans and that more work needs to be done to analyze the role of SI in the archaic introgression landscape of living humans.
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- 2018
12. Author Correction: The Anglo-Saxon migration and the formation of the early English gene pool
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Gretzinger, Joscha, Sayer, Duncan, Justeau, Pierre, Altena, Eveline, Pala, Maria, Dulias, Katharina, Edwards, Ceiridwen J., Jodoin, Susanne, Lacher, Laura, Sabin, Susanna, Vågene, Åshild J., Haak, Wolfgang, Ebenesersdóttir, S. Sunna, Moore, Kristjan H. S., Radzeviciute, Rita, Schmidt, Kara, Brace, Selina, Bager, Martina Abenhus, Patterson, Nick, Papac, Luka, Broomandkhoshbacht, Nasreen, Callan, Kimberly, Harney, Éadaoin, Iliev, Lora, Lawson, Ann Marie, Michel, Megan, Stewardson, Kristin, Zalzala, Fatma, Rohland, Nadin, Kappelhoff-Beckmann, Stefanie, Both, Frank, Winger, Daniel, Neumann, Daniel, Saalow, Lars, Krabath, Stefan, Beckett, Sophie, Van Twest, Melanie, Faulkner, Neil, Read, Chris, Barton, Tabatha, Caruth, Joanna, Hines, John, Krause-Kyora, Ben, Warnke, Ursula, Schuenemann, Verena J., Barnes, Ian, Dahlström, Hanna, Clausen, Jane Jark, Richardson, Andrew, Popescu, Elizabeth, Dodwell, Natasha, Ladd, Stuart, Phillips, Tom, Mortimer, Richard, Sayer, Faye, Swales, Diana, Stewart, Allison, Powlesland, Dominic, Kenyon, Robert, Ladle, Lilian, Peek, Christina, Grefen-Peters, Silke, Ponce, Paola, Daniels, Robin, Spall, Cecily, Woolcock, Jennifer, Jones, Andy M., Roberts, Amy V., Symmons, Robert, Rawden, Anooshka C., Cooper, Alan, Bos, Kirsten I., Booth, Tom, Schroeder, Hannes, Thomas, Mark G., Helgason, Agnar, Richards, Martin B., Reich, David, Krause, Johannes, and Schiffels, Stephan
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- 2022
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13. Genomic analyses inform on migration events during the peopling of Eurasia
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Pagani, Luca, Lawson, Daniel John, Jagoda, Evelyn, Mörseburg, Alexander, Eriksson, Anders, Mitt, Mario, Clemente, Florian, Hudjashov, Georgi, DeGiorgio, Michael, Saag, Lauri, Wall, Jeffrey D, Cardona, Alexia, Mägi, Reedik, Sayres, Melissa A Wilson, Kaewert, Sarah, Inchley, Charlotte, Scheib, Christiana L, Järve, Mari, Karmin, Monika, Jacobs, Guy S, Antao, Tiago, Iliescu, Florin Mircea, Kushniarevich, Alena, Ayub, Qasim, Tyler-Smith, Chris, Xue, Yali, Yunusbayev, Bayazit, Tambets, Kristiina, Mallick, Chandana Basu, Saag, Lehti, Pocheshkhova, Elvira, Andriadze, George, Muller, Craig, Westaway, Michael C, Lambert, David M, Zoraqi, Grigor, Turdikulova, Shahlo, Dalimova, Dilbar, Sabitov, Zhaxylyk, Sultana, Gazi Nurun Nahar, Lachance, Joseph, Tishkoff, Sarah, Momynaliev, Kuvat, Isakova, Jainagul, Damba, Larisa D, Gubina, Marina, Nymadawa, Pagbajabyn, Evseeva, Irina, Atramentova, Lubov, Utevska, Olga, Ricaut, François-Xavier, Brucato, Nicolas, Sudoyo, Herawati, Letellier, Thierry, Cox, Murray P, Barashkov, Nikolay A, Škaro, Vedrana, Mulahasanovic´, Lejla, Primorac, Dragan, Sahakyan, Hovhannes, Mormina, Maru, Eichstaedt, Christina A, Lichman, Daria V, Abdullah, Syafiq, Chaubey, Gyaneshwer, Wee, Joseph TS, Mihailov, Evelin, Karunas, Alexandra, Litvinov, Sergei, Khusainova, Rita, Ekomasova, Natalya, Akhmetova, Vita, Khidiyatova, Irina, Marjanović, Damir, Yepiskoposyan, Levon, Behar, Doron M, Balanovska, Elena, Metspalu, Andres, Derenko, Miroslava, Malyarchuk, Boris, Voevoda, Mikhail, Fedorova, Sardana A, Osipova, Ludmila P, Lahr, Marta Mirazón, Gerbault, Pascale, Leavesley, Matthew, Migliano, Andrea Bamberg, Petraglia, Michael, Balanovsky, Oleg, Khusnutdinova, Elza K, Metspalu, Ene, Thomas, Mark G, Manica, Andrea, Nielsen, Rasmus, Villems, Richard, Willerslev, Eske, Kivisild, Toomas, and Metspalu, Mait
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Human Genome ,Biotechnology ,Genetics ,Generic health relevance ,Africa ,Animals ,Asia ,Datasets as Topic ,Estonia ,Europe ,Fossils ,Gene Flow ,Genetics ,Population ,Genome ,Human ,Genomics ,Heterozygote ,History ,Ancient ,Human Migration ,Humans ,Native Hawaiian or Other Pacific Islander ,Neanderthals ,New Guinea ,Population Dynamics ,Racial Groups ,General Science & Technology - Abstract
High-coverage whole-genome sequence studies have so far focused on a limited number of geographically restricted populations, or been targeted at specific diseases, such as cancer. Nevertheless, the availability of high-resolution genomic data has led to the development of new methodologies for inferring population history and refuelled the debate on the mutation rate in humans. Here we present the Estonian Biocentre Human Genome Diversity Panel (EGDP), a dataset of 483 high-coverage human genomes from 148 populations worldwide, including 379 new genomes from 125 populations, which we group into diversity and selection sets. We analyse this dataset to refine estimates of continent-wide patterns of heterozygosity, long- and short-distance gene flow, archaic admixture, and changes in effective population size through time as well as for signals of positive or balancing selection. We find a genetic signature in present-day Papuans that suggests that at least 2% of their genome originates from an early and largely extinct expansion of anatomically modern humans (AMHs) out of Africa. Together with evidence from the western Asian fossil record, and admixture between AMHs and Neanderthals predating the main Eurasian expansion, our results contribute to the mounting evidence for the presence of AMHs out of Africa earlier than 75,000 years ago.
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- 2016
14. A genomic history of Aboriginal Australia
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Malaspinas, Anna-Sapfo, Westaway, Michael C, Muller, Craig, Sousa, Vitor C, Lao, Oscar, Alves, Isabel, Bergström, Anders, Athanasiadis, Georgios, Cheng, Jade Y, Crawford, Jacob E, Heupink, Tim H, Macholdt, Enrico, Peischl, Stephan, Rasmussen, Simon, Schiffels, Stephan, Subramanian, Sankar, Wright, Joanne L, Albrechtsen, Anders, Barbieri, Chiara, Dupanloup, Isabelle, Eriksson, Anders, Margaryan, Ashot, Moltke, Ida, Pugach, Irina, Korneliussen, Thorfinn S, Levkivskyi, Ivan P, Moreno-Mayar, J Víctor, Ni, Shengyu, Racimo, Fernando, Sikora, Martin, Xue, Yali, Aghakhanian, Farhang A, Brucato, Nicolas, Brunak, Søren, Campos, Paula F, Clark, Warren, Ellingvåg, Sturla, Fourmile, Gudjugudju, Gerbault, Pascale, Injie, Darren, Koki, George, Leavesley, Matthew, Logan, Betty, Lynch, Aubrey, Matisoo-Smith, Elizabeth A, McAllister, Peter J, Mentzer, Alexander J, Metspalu, Mait, Migliano, Andrea B, Murgha, Les, Phipps, Maude E, Pomat, William, Reynolds, Doc, Ricaut, Francois-Xavier, Siba, Peter, Thomas, Mark G, Wales, Thomas, Wall, Colleen Ma’run, Oppenheimer, Stephen J, Tyler-Smith, Chris, Durbin, Richard, Dortch, Joe, Manica, Andrea, Schierup, Mikkel H, Foley, Robert A, Lahr, Marta Mirazón, Bowern, Claire, Wall, Jeffrey D, Mailund, Thomas, Stoneking, Mark, Nielsen, Rasmus, Sandhu, Manjinder S, Excoffier, Laurent, Lambert, David M, and Willerslev, Eske
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Africa ,Australia ,Datasets as Topic ,Desert Climate ,Gene Flow ,Genetics ,Population ,Genome ,Human ,Genomics ,History ,Ancient ,Human Migration ,Humans ,Language ,Native Hawaiian or Other Pacific Islander ,New Guinea ,Phylogeny ,Population Dynamics ,Racial Groups ,Tasmania ,General Science & Technology - Abstract
The population history of Aboriginal Australians remains largely uncharacterized. Here we generate high-coverage genomes for 83 Aboriginal Australians (speakers of Pama-Nyungan languages) and 25 Papuans from the New Guinea Highlands. We find that Papuan and Aboriginal Australian ancestors diversified 25-40 thousand years ago (kya), suggesting pre-Holocene population structure in the ancient continent of Sahul (Australia, New Guinea and Tasmania). However, all of the studied Aboriginal Australians descend from a single founding population that differentiated ~10-32 kya. We infer a population expansion in northeast Australia during the Holocene epoch (past 10,000 years) associated with limited gene flow from this region to the rest of Australia, consistent with the spread of the Pama-Nyungan languages. We estimate that Aboriginal Australians and Papuans diverged from Eurasians 51-72 kya, following a single out-of-Africa dispersal, and subsequently admixed with archaic populations. Finally, we report evidence of selection in Aboriginal Australians potentially associated with living in the desert.
- Published
- 2016
15. Genetic legacy of state centralization in the Kuba Kingdom of the Democratic Republic of the Congo
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van Dorp, Lucy, Lowes, Sara, Weigel, Jonathan L., Ansari-Pour, Naser, López, Saioa, Mendoza-Revilla, Javier, Robinson, James A., Henrich, Joseph, Thomas, Mark G., Nunn, Nathan, and Hellenthal, Garrett
- Published
- 2019
16. Ancient human genomes suggest three ancestral populations for present-day Europeans
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Lazaridis, Iosif, Patterson, Nick, Mittnik, Alissa, Renaud, Gabriel, Mallick, Swapan, Kirsanow, Karola, Sudmant, Peter H., Schraiber, Joshua G., Castellano, Sergi, Lipson, Mark, Berger, Bonnie, Economou, Christos, Bollongino, Ruth, Fu, Qiaomei, Bos, Kirsten I., Nordenfelt, Susanne, Li, Heng, de Filippo, Cesare, Prüfer, Kay, Sawyer, Susanna, Posth, Cosimo, Haak, Wolfgang, Hallgren, Fredrik, Fornander, Elin, Rohland, Nadin, Delsate, Dominique, Francken, Michael, Guinet, Jean-Michel, Wahl, Joachim, Ayodo, George, Babiker, Hamza A., Bailliet, Graciela, Balanovska, Elena, Balanovsky, Oleg, Barrantes, Ramiro, Bedoya, Gabriel, Ben-Ami, Haim, Bene, Judit, Berrada, Fouad, Bravi, Claudio M., Brisighelli, Francesca, Busby, George, Cali, Francesco, Churnosov, Mikhail, Cole, David E. C., Corach, Daniel, Damba, Larissa, van Driem, George, Dryomov, Stanislav, Dugoujon, Jean-Michel, Fedorova, Sardana A., Romero, Irene Gallego, Gubina, Marina, Hammer, Michael, Henn, Brenna, Hervig, Tor, Hodoglugil, Ugur, Jha, Aashish R., Karachanak-Yankova, Sena, Khusainova, Rita, Khusnutdinova, Elza, Kittles, Rick, Kivisild, Toomas, Klitz, William, Kučinskas, Vaidutis, Kushniarevich, Alena, Laredj, Leila, Litvinov, Sergey, Loukidis, Theologos, Mahley, Robert W., Melegh, Béla, Metspalu, Ene, Molina, Julio, Mountain, Joanna, Näkkäläjärvi, Klemetti, Nesheva, Desislava, Nyambo, Thomas, Osipova, Ludmila, Parik, Jüri, Platonov, Fedor, Posukh, Olga, Romano, Valentino, Rothhammer, Francisco, Rudan, Igor, Ruizbakiev, Ruslan, Sahakyan, Hovhannes, Sajantila, Antti, Salas, Antonio, Starikovskaya, Elena B., Tarekegn, Ayele, Toncheva, Draga, Turdikulova, Shahlo, Uktveryte, Ingrida, Utevska, Olga, Vasquez, René, Villena, Mercedes, Voevoda, Mikhail, Winkler, Cheryl, Yepiskoposyan, Levon, Zalloua, Pierre, Zemunik, Tatijana, Cooper, Alan, Capelli, Cristian, Thomas, Mark G., Ruiz-Linares, Andres, Tishkoff, Sarah A., Singh, Lalji, Thangaraj, Kumarasamy, Villems, Richard, Comas, David, Sukernik, Rem, Metspalu, Mait, Meyer, Matthias, Eichler, Evan E., Burger, Joachim, Slatkin, Montgomery, Pääbo, Svante, Kelso, Janet, Reich, David, and Krause, Johannes
- Subjects
Quantitative Biology - Populations and Evolution - Abstract
We sequenced genomes from a $\sim$7,000 year old early farmer from Stuttgart in Germany, an $\sim$8,000 year old hunter-gatherer from Luxembourg, and seven $\sim$8,000 year old hunter-gatherers from southern Sweden. We analyzed these data together with other ancient genomes and 2,345 contemporary humans to show that the great majority of present-day Europeans derive from at least three highly differentiated populations: West European Hunter-Gatherers (WHG), who contributed ancestry to all Europeans but not to Near Easterners; Ancient North Eurasians (ANE), who were most closely related to Upper Paleolithic Siberians and contributed to both Europeans and Near Easterners; and Early European Farmers (EEF), who were mainly of Near Eastern origin but also harbored WHG-related ancestry. We model these populations' deep relationships and show that EEF had $\sim$44% ancestry from a "Basal Eurasian" lineage that split prior to the diversification of all other non-African lineages.
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- 2013
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17. Evidence of the interplay of genetics and culture in Ethiopia
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López, Saioa, Tarekegn, Ayele, Band, Gavin, van Dorp, Lucy, Bird, Nancy, Morris, Sam, Oljira, Tamiru, Mekonnen, Ephrem, Bekele, Endashaw, Blench, Roger, Thomas, Mark G., Bradman, Neil, and Hellenthal, Garrett
- Published
- 2021
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18. Author Correction: Dairying, diseases and the evolution of lactase persistence in Europe
- Author
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Evershed, Richard P., Davey Smith, George, Roffet-Salque, Mélanie, Timpson, Adrian, Diekmann, Yoan, Lyon, Matthew S., Cramp, Lucy J. E., Casanova, Emmanuelle, Smyth, Jessica, Whelton, Helen L., Dunne, Julie, Brychova, Veronika, Šoberl, Lucija, Gerbault, Pascale, Gillis, Rosalind E., Heyd, Volker, Johnson, Emily, Kendall, Iain, Manning, Katie, Marciniak, Arkadiusz, Outram, Alan K., Vigne, Jean-Denis, Shennan, Stephen, Bevan, Andrew, Colledge, Sue, Allason-Jones, Lyndsay, Amkreutz, Luc, Anders, Alexandra, Arbogast, Rose-Marie, Bălăşescu, Adrian, Bánffy, Eszter, Barclay, Alistair, Behrens, Anja, Bogucki, Peter, Carrancho Alonso, Ángel, Carretero, José Miguel, Cavanagh, Nigel, Claßen, Erich, Collado Giraldo, Hipolito, Conrad, Matthias, Csengeri, Piroska, Czerniak, Lech, Dębiec, Maciej, Denaire, Anthony, Domboróczki, László, Donald, Christina, Ebert, Julia, Evans, Christopher, Francés-Negro, Marta, Gronenborn, Detlef, Haack, Fabian, Halle, Matthias, Hamon, Caroline, Hülshoff, Roman, Ilett, Michael, Iriarte, Eneko, Jakucs, János, Jeunesse, Christian, Johnson, Melanie, Jones, Andy M., Karul, Necmi, Kiosak, Dmytro, Kotova, Nadezhda, Krause, Rüdiger, Kretschmer, Saskia, Krüger, Marta, Lefranc, Philippe, Lelong, Olivia, Lenneis, Eva, Logvin, Andrey, Lüth, Friedrich, Marton, Tibor, Marley, Jane, Mortimer, Richard, Oosterbeek, Luiz, Oross, Krisztián, Pavúk, Juraj, Pechtl, Joachim, Pétrequin, Pierre, Pollard, Joshua, Pollard, Richard, Powlesland, Dominic, Pyzel, Joanna, Raczky, Pál, Richardson, Andrew, Rowe, Peter, Rowland, Stephen, Rowlandson, Ian, Saile, Thomas, Sebők, Katalin, Schier, Wolfram, Schmalfuß, Germo, Sharapova, Svetlana, Sharp, Helen, Sheridan, Alison, Shevnina, Irina, Sobkowiak-Tabaka, Iwona, Stadler, Peter, Stäuble, Harald, Stobbe, Astrid, Stojanovski, Darko, Tasić, Nenad, van Wijk, Ivo, Vostrovská, Ivana, Vuković, Jasna, Wolfram, Sabine, Zeeb-Lanz, Andrea, and Thomas, Mark G.
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- 2022
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19. Ancient West African foragers in the context of African population history
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Lipson, Mark, Ribot, Isabelle, Mallick, Swapan, Rohland, Nadin, Olalde, Iñigo, Adamski, Nicole, Broomandkhoshbacht, Nasreen, Lawson, Ann Marie, López, Saioa, Oppenheimer, Jonas, Stewardson, Kristin, Asombang, Raymond Neba’ane, Bocherens, Hervé, Bradman, Neil, Culleton, Brendan J., Cornelissen, Els, Crevecoeur, Isabelle, de Maret, Pierre, Fomine, Forka Leypey Mathew, Lavachery, Philippe, Mindzie, Christophe Mbida, Orban, Rosine, Sawchuk, Elizabeth, Semal, Patrick, Thomas, Mark G., Van Neer, Wim, Veeramah, Krishna R., Kennett, Douglas J., Patterson, Nick, Hellenthal, Garrett, Lalueza-Fox, Carles, MacEachern, Scott, Prendergast, Mary E., and Reich, David
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- 2020
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20. A recent bottleneck of Y chromosome diversity coincides with a global change in culture
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Karmin, Monika, Saag, Lauri, Vicente, Mário, Sayres, Melissa A Wilson, Järve, Mari, Talas, Ulvi Gerst, Rootsi, Siiri, Ilumäe, Anne-Mai, Mägi, Reedik, Mitt, Mario, Pagani, Luca, Puurand, Tarmo, Faltyskova, Zuzana, Clemente, Florian, Cardona, Alexia, Metspalu, Ene, Sahakyan, Hovhannes, Yunusbayev, Bayazit, Hudjashov, Georgi, DeGiorgio, Michael, Loogväli, Eva-Liis, Eichstaedt, Christina, Eelmets, Mikk, Chaubey, Gyaneshwer, Tambets, Kristiina, Litvinov, Sergei, Mormina, Maru, Xue, Yali, Ayub, Qasim, Zoraqi, Grigor, Korneliussen, Thorfinn Sand, Akhatova, Farida, Lachance, Joseph, Tishkoff, Sarah, Momynaliev, Kuvat, Ricaut, François-Xavier, Kusuma, Pradiptajati, Razafindrazaka, Harilanto, Pierron, Denis, Cox, Murray P, Sultana, Gazi Nurun Nahar, Willerslev, Rane, Muller, Craig, Westaway, Michael, Lambert, David, Skaro, Vedrana, Kovačevic´, Lejla, Turdikulova, Shahlo, Dalimova, Dilbar, Khusainova, Rita, Trofimova, Natalya, Akhmetova, Vita, Khidiyatova, Irina, Lichman, Daria V, Isakova, Jainagul, Pocheshkhova, Elvira, Sabitov, Zhaxylyk, Barashkov, Nikolay A, Nymadawa, Pagbajabyn, Mihailov, Evelin, Seng, Joseph Wee Tien, Evseeva, Irina, Migliano, Andrea Bamberg, Abdullah, Syafiq, Andriadze, George, Primorac, Dragan, Atramentova, Lubov, Utevska, Olga, Yepiskoposyan, Levon, Marjanovic´, Damir, Kushniarevich, Alena, Behar, Doron M, Gilissen, Christian, Vissers, Lisenka, Veltman, Joris A, Balanovska, Elena, Derenko, Miroslava, Malyarchuk, Boris, Metspalu, Andres, Fedorova, Sardana, Eriksson, Anders, Manica, Andrea, Mendez, Fernando L, Karafet, Tatiana M, Veeramah, Krishna R, Bradman, Neil, Hammer, Michael F, Osipova, Ludmila P, Balanovsky, Oleg, Khusnutdinova, Elza K, Johnsen, Knut, Remm, Maido, Thomas, Mark G, Tyler-Smith, Chris, Underhill, Peter A, Willerslev, Eske, Nielsen, Rasmus, Metspalu, Mait, Villems, Richard, and Kivisild, Toomas
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Biological Sciences ,Genetics ,Human Genome ,Base Sequence ,Chromosomes ,Human ,Y ,DNA ,Mitochondrial ,Evolution ,Molecular ,Genetic Variation ,Genetics ,Population ,Haplotypes ,Humans ,Male ,Models ,Genetic ,Phylogeny ,Racial Groups ,Sequence Analysis ,DNA ,Medical and Health Sciences ,Bioinformatics - Abstract
It is commonly thought that human genetic diversity in non-African populations was shaped primarily by an out-of-Africa dispersal 50-100 thousand yr ago (kya). Here, we present a study of 456 geographically diverse high-coverage Y chromosome sequences, including 299 newly reported samples. Applying ancient DNA calibration, we date the Y-chromosomal most recent common ancestor (MRCA) in Africa at 254 (95% CI 192-307) kya and detect a cluster of major non-African founder haplogroups in a narrow time interval at 47-52 kya, consistent with a rapid initial colonization model of Eurasia and Oceania after the out-of-Africa bottleneck. In contrast to demographic reconstructions based on mtDNA, we infer a second strong bottleneck in Y-chromosome lineages dating to the last 10 ky. We hypothesize that this bottleneck is caused by cultural changes affecting variance of reproductive success among males.
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- 2015
21. A 3,000-year-old Egyptian emmer wheat genome reveals dispersal and domestication history
- Author
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Scott, Michael F., Botigué, Laura R., Brace, Selina, Stevens, Chris J., Mullin, Victoria E., Stevenson, Alice, Thomas, Mark G., Fuller, Dorian Q., and Mott, Richard
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- 2019
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22. Modelling caprine age-at-death profiles using the Gamma distribution
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Timpson, Adrian, Gillis, Rosalind E., Manning, Katie, and Thomas, Mark G.
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- 2018
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23. Storytelling and story testing in domestication
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Gerbault, Pascale, Allaby, Robin G, Boivin, Nicole, Rudzinski, Anna, Grimaldi, Ilaria M, Pires, J Chris, Vigueira, Cynthia Climer, Dobney, Keith, Gremillion, Kristen J, Barton, Loukas, Arroyo-Kalin, Manuel, Purugganan, Michael D, de Casas, Rafael Rubio, Bollongino, Ruth, Burger, Joachim, Fuller, Dorian Q, Bradley, Daniel G, Balding, David J, Richerson, Peter J, Gilbert, M Thomas P, Larson, Greger, and Thomas, Mark G
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Generic health relevance ,Animals ,Animals ,Domestic ,Crops ,Agricultural ,Humans ,Hybridization ,Genetic ,Models ,Biological ,Narration ,model ,inference ,evolution ,agriculture ,Neolithic - Abstract
The domestication of plants and animals marks one of the most significant transitions in human, and indeed global, history. Traditionally, study of the domestication process was the exclusive domain of archaeologists and agricultural scientists; today it is an increasingly multidisciplinary enterprise that has come to involve the skills of evolutionary biologists and geneticists. Although the application of new information sources and methodologies has dramatically transformed our ability to study and understand domestication, it has also generated increasingly large and complex datasets, the interpretation of which is not straightforward. In particular, challenges of equifinality, evolutionary variance, and emergence of unexpected or counter-intuitive patterns all face researchers attempting to infer past processes directly from patterns in data. We argue that explicit modeling approaches, drawing upon emerging methodologies in statistics and population genetics, provide a powerful means of addressing these limitations. Modeling also offers an approach to analyzing datasets that avoids conclusions steered by implicit biases, and makes possible the formal integration of different data types. Here we outline some of the modeling approaches most relevant to current problems in domestication research, and demonstrate the ways in which simulation modeling is beginning to reshape our understanding of the domestication process.
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- 2014
24. Current perspectives and the future of domestication studies
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Larson, Greger, Piperno, Dolores R, Allaby, Robin G, Purugganan, Michael D, Andersson, Leif, Arroyo-Kalin, Manuel, Barton, Loukas, Vigueira, Cynthia Climer, Denham, Tim, Dobney, Keith, Doust, Andrew N, Gepts, Paul, Gilbert, M Thomas P, Gremillion, Kristen J, Lucas, Leilani, Lukens, Lewis, Marshall, Fiona B, Olsen, Kenneth M, Pires, J Chris, Richerson, Peter J, de Casas, Rafael Rubio, Sanjur, Oris I, Thomas, Mark G, and Fuller, Dorian Q
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Animals ,Animals ,Domestic ,Biological Evolution ,Crops ,Agricultural ,Environment ,Geography ,Spatio-Temporal Analysis ,evolution ,selection ,agriculture ,human ecology ,human history - Abstract
It is difficult to overstate the cultural and biological impacts that the domestication of plants and animals has had on our species. Fundamental questions regarding where, when, and how many times domestication took place have been of primary interest within a wide range of academic disciplines. Within the last two decades, the advent of new archaeological and genetic techniques has revolutionized our understanding of the pattern and process of domestication and agricultural origins that led to our modern way of life. In the spring of 2011, 25 scholars with a central interest in domestication representing the fields of genetics, archaeobotany, zooarchaeology, geoarchaeology, and archaeology met at the National Evolutionary Synthesis Center to discuss recent domestication research progress and identify challenges for the future. In this introduction to the resulting Special Feature, we present the state of the art in the field by discussing what is known about the spatial and temporal patterns of domestication, and controversies surrounding the speed, intentionality, and evolutionary aspects of the domestication process. We then highlight three key challenges for future research. We conclude by arguing that although recent progress has been impressive, the next decade will yield even more substantial insights not only into how domestication took place, but also when and where it did, and where and why it did not.
- Published
- 2014
25. Postglacial genomes from foragers across Northern Eurasia reveal prehistoric mobility associated with the spread of the Uralic and Yeniseian languages
- Author
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Zeng, Tian Chen, primary, Vyazov, Leonid A., additional, Kim, Alexander, additional, Flegontov, Pavel, additional, Sirak, Kendra, additional, Maier, Robert, additional, Lazaridis, Iosif, additional, Akbari, Ali, additional, Frachetti, Michael, additional, Tishkin, Alexey A., additional, Ryabogina, Natalia E., additional, Agapov, Sergey A., additional, Agapov, Danila S., additional, Alekseev, Anatoliy N., additional, Boeskorov, Gennady G., additional, Derevianko, Anatoly P., additional, Dyakonov, Viktor M., additional, Enshin, Dmitry N., additional, Fribus, Alexey V., additional, Frolov, Yaroslav V., additional, Grushin, Sergey P., additional, Khokhlov, Alexander A., additional, Kiryushin, Kirill Yu, additional, Kiryushin, Yurii F., additional, Kitov, Egor P., additional, Kosintsev, Pavel, additional, Kovtun, Igor V., additional, Makarov, Nikolai P., additional, Morozov, Viktor V., additional, Nikolaev, Egor N., additional, Rykun, Marina P., additional, Savenkova, Tatyana M., additional, Shchelchkova, Marina V., additional, Shirokov, Vladimir, additional, Skochina, Svetlana N., additional, Sherstobitova, Olga S., additional, Slepchenko, Sergey M., additional, Solodovnikov, Konstantin N., additional, Solovyova, Elena N., additional, Stepanov, Aleksandr D., additional, Timoshchenko, Aleksei A., additional, Vdovin, Aleksandr S., additional, Vybornov, Anton V., additional, Balanovska, Elena V., additional, Dryomov, Stanislav, additional, Hellenthal, Garrett, additional, Kidd, Kenneth, additional, Krause, Johannes, additional, Starikovskaya, Elena, additional, Sukenik, Rem, additional, Tatarinova, Tatiana, additional, Thomas, Mark G., additional, Zhabagin, Maxat, additional, Callan, Kim, additional, Cheronet, Olivia, additional, Fernandes, Daniel, additional, Keating, Denise, additional, Francesca, Candilio, additional, Iliev, Lora, additional, Kearns, Aisling, additional, Özdoğan, Kadir Toykan, additional, Mah, Matthew, additional, Micco, Adam, additional, Michel, Megan, additional, Olalde, Iñigo, additional, Zalzala, Fatma, additional, Mallick, Swapan, additional, Rohland, Nadin, additional, Pinhasi, Ron, additional, Narasimhan, Vagheesh, additional, and Reich, David, additional
- Published
- 2023
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- View/download PDF
26. Synchronous diversification of Sulawesi’s iconic artiodactyls driven by recent geological events
- Author
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Frantz, Laurent A. F., Rudzinski, Anna, Nugraha, Abang Mansyursyah Surya, Evin, Allowen, Burton, James, Hulme-Beaman, Ardern, Linderholm, Anna, Barnett, Ross, Vega, Rodrigo, Irving-Pease, Evan K., Haile, James, Allen, Richard, Leus, Kristin, Shephard, Jill, Hillyer, Mia, Gillemot, Sarah, van den Hurk, Jeroen, Ogle, Sharron, Atofanei, Cristina, Thomas, Mark G., Johansson, Friederike, Mustari, Abdul Haris, Williams, John, Mohamad, Kusdiantoro, Damayanti, Chandramaya Siska, Wiryadik, Ita Djuwita, Obbles, Dagmar, Mona, Stephano, Day, Hally, Yasin, Muhammad, Meker, Stefan, McGuire, Jimmy A., Evans, Ben J., von Rintelen, Thomas, Ho, Simon Y. W., Searle, Jeremy B., Kitchener, Andrew C., Macdonald, Alastair A., Shaw, Darren J., Hall, Robert, Galbusera, Peter, and Larson, Greger
- Published
- 2018
27. Estimating mobility using sparse data : Application to human genetic variation
- Author
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Loog, Liisa, Lahr, Marta Mirazón, Kovacevic, Mirna, Manica, Andrea, Eriksson, Anders, and Thomas, Mark G.
- Published
- 2017
28. Reduced intensity of bone fat exploitation correlates with increased potential access to dairy fats in early Neolithic Europe
- Author
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Johnson, Emily V., Timpson, Adrian, Thomas, Mark G., and Outram, Alan K.
- Published
- 2018
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29. Long-Term Stable Bone Mineral Density in HIV-Infected Men Without Risk Factors for Osteoporosis Treated with Antiretroviral Therapy
- Author
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Bolland, Mark J., Horne, Anne M., Briggs, Simon E., Thomas, Mark G., Reid, Ian R., Gamble, Greg D., and Grey, Andrew
- Published
- 2019
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30. The use of a poster to reduce expectations to receive antibiotics for a common cold
- Author
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Ritchie, Stephen R., Rakhmanova, Lizzie, Out-O’Reilly, Eilish, Reay, Stephen, Thomas, Mark G., and Sajtos, Laszlo
- Published
- 2019
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31. Ancient genomes indicate population replacement in Early Neolithic Britain
- Author
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Brace, Selina, Diekmann, Yoan, Booth, Thomas J., van Dorp, Lucy, Faltyskova, Zuzana, Rohland, Nadin, Mallick, Swapan, Olalde, Iñigo, Ferry, Matthew, Michel, Megan, Oppenheimer, Jonas, Broomandkhoshbacht, Nasreen, Stewardson, Kristin, Martiniano, Rui, Walsh, Susan, Kayser, Manfred, Charlton, Sophy, Hellenthal, Garrett, Armit, Ian, Schulting, Rick, Craig, Oliver E., Sheridan, Alison, Parker Pearson, Mike, Stringer, Chris, Reich, David, Thomas, Mark G., and Barnes, Ian
- Published
- 2019
- Full Text
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32. Little genetic differentiation as assessed by uniparental markers in the presence of substantial language variation in peoples of the Cross River region of Nigeria
- Author
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Veeramah, Krishna R, Connell, Bruce A, Pour, Naser, Powell, Adam, Plaster, Christopher A, Zeitlyn, David, Mendell, Nancy R, Weale, Michael E, Bradman, Neil, and Thomas, Mark G
- Abstract
Abstract Background The Cross River region in Nigeria is an extremely diverse area linguistically with over 60 distinct languages still spoken today. It is also a region of great historical importance, being a) adjacent to the likely homeland from which Bantu-speaking people migrated across most of sub-Saharan Africa 3000-5000 years ago and b) the location of Calabar, one of the largest centres during the Atlantic slave trade. Over 1000 DNA samples from 24 clans representing speakers of the six most prominent languages in the region were collected and typed for Y-chromosome (SNPs and microsatellites) and mtDNA markers (Hypervariable Segment 1) in order to examine whether there has been substantial gene flow between groups speaking different languages in the region. In addition the Cross River region was analysed in the context of a larger geographical scale by comparison to bordering Igbo speaking groups as well as neighbouring Cameroon populations and more distant Ghanaian communities. Results The Cross River region was shown to be extremely homogenous for both Y-chromosome and mtDNA markers with language spoken having no noticeable effect on the genetic structure of the region, consistent with estimates of inter-language gene flow of 10% per generation based on sociological data. However the groups in the region could clearly be differentiated from others in Cameroon and Ghana (and to a lesser extent Igbo populations). Significant correlations between genetic distance and both geographic and linguistic distance were observed at this larger scale. Conclusions Previous studies have found significant correlations between genetic variation and language in Africa over large geographic distances, often across language families. However the broad sampling strategies of these datasets have limited their utility for understanding the relationship within language families. This is the first study to show that at very fine geographic/linguistic scales language differences can be maintained in the presence of substantial gene flow over an extended period of time and demonstrates the value of dense sampling strategies and having DNA of known and detailed provenance, a practice that is generally rare when investigating sub-Saharan African demographic processes using genetic data.
- Published
- 2010
33. Accurate age estimation in small-scale societies
- Author
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Diekmann, Yoan, Smith, Daniel, Gerbault, Pascale, Dyble, Mark, Page, Abigail E., Chaudhary, Nikhil, Migliano, Andrea Bamberg, and Thomas, Mark G.
- Published
- 2017
34. Long-Term Impact of a Smartphone App on Prescriber Adherence to Antibiotic Guidelines for Adult Patients With Community-Acquired Pneumonia: Interrupted Time-Series Study
- Author
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Yoon, Chang Ho, primary, Nolan, Imogen, additional, Humphrey, Gayl, additional, Duffy, Eamon J, additional, Thomas, Mark G, additional, and Ritchie, Stephen R, additional
- Published
- 2023
- Full Text
- View/download PDF
35. Understanding cumulative cultural evolution
- Author
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Henrich, Joseph, Boyd, Robert, Derex, Maxime, Kline, Michelle A., Mesoudi, Alex, Muthukrishna, Michael, Powell, Adam T., Shennan, Stephen J., and Thomas, Mark G.
- Published
- 2016
36. Genetic Evidence for Different Male and Female Roles during Cultural Transitions in the British Isles
- Author
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Wilson, James F., Weiss, Deborah A., Richards, Martin, Thomas, Mark G., Bradman, Neil, and Goldstein, David B.
- Published
- 2001
37. Changing Mindsets About Side Effects of the COVID-19 Vaccination: A Randomized Controlled Trial.
- Author
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Crum, Alia J, Heathcote, Lauren C, Morrison, Zara, Yielder, Rachael, Leibowitz, Kari, Petousis-Harris, Helen, Thomas, Mark G, Prober, Charles G, Berek, Jonathan S, and Petrie, Keith J
- Subjects
VACCINATION complications ,RANDOMIZED controlled trials ,VACCINE hesitancy ,COVID-19 vaccines ,COVID-19 ,CANCER fatigue - Abstract
Background Side-effect concerns are a major barrier to vaccination against COVID-19 and other diseases. Identifying cost- and time-efficient interventions to improve vaccine experience and reduce vaccine hesitancy—without withholding information about side effects—is critical. Purpose Determine whether a brief symptom as positive signals mindset intervention can improve vaccine experience and reduce vaccine hesitancy after the COVID-19 vaccination. Methods English-speaking adults (18+) were recruited during the 15-min wait period after receiving their second dose of the Pfizer COVID-19 vaccination and were randomly allocated to the symptom as positive signals mindset condition or the treatment as usual control. Participants in the mindset intervention viewed a 3:43-min video explaining how the body responds to vaccinations and how common side effects such as fatigue, sore arm, and fever are signs that the vaccination is helping the body boost immunity. The control group received standard vaccination center information. Results Mindset participants (N = 260) versus controls (N = 268) reported significantly less worry about symptoms at day 3 [ t (506)=2.60, p =.01, d =0.23], fewer symptoms immediately following the vaccine [ t (484)=2.75, p =.006, d =0.24], and increased intentions to vaccinate against viruses like COVID-19 in the future [ t (514)=−2.57, p =.01, d =0.22]. No significant differences for side-effect frequency at day 3, coping, or impact. Conclusions This study supports the use of a brief video aimed at reframing symptoms as positive signals to reduce worry and increase future vaccine intentions. Clinical Trial information Australian New Zealand Clinical Trials Registry: ACTRN12621000722897p. [ABSTRACT FROM AUTHOR]
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- 2023
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38. Molecular and Morphological Evidence on the Phylogeny of the Elephantidae
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Thomas, Mark G., Hagelberg, Erika, Jones, Hywel B., Yang, Ziheng, and Lister, Adrian M.
- Published
- 2000
39. List of contributors
- Author
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Dickhoff, Bastiaan H.J., primary, Gänzle, Michael G., additional, Hebbink, Gerald A., additional, Hettinga, Kasper A., additional, Szilagyi, Andrew, additional, Thomas, Mark G., additional, and Walker, Catherine, additional
- Published
- 2019
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40. Lactose intolerance and other related food sensitivities
- Author
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Szilagyi, Andrew, primary, Walker, Catherine, additional, and Thomas, Mark G., additional
- Published
- 2019
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41. The evolution of lactose digestion
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Walker, Catherine, primary and Thomas, Mark G., additional
- Published
- 2019
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42. Beyond multiregional and simple out-of-Africa models of human evolution
- Author
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Scerri, Eleanor M. L., Chikhi, Lounès, and Thomas, Mark G.
- Published
- 2019
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43. Simulating Geographical Variation in Material Culture: Were Early Modern Humans in Europe Ethnically Structured?
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Kovacevic, Mirna, Shennan, Stephen, Vanhaeren, Marian, d’Errico, Francesco, Thomas, Mark G., Mesoudi, Alex, editor, and Aoki, Kenichi, editor
- Published
- 2015
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44. Molecular Instability in the COII-tRNALys Intergenic Region of the Human Mitochondrial Genome: Multiple Origins of the 9-bp Deletion and Heteroplasmy for Expanded Repeats
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Thomas, Mark G., Cook, Charles E., Waring, Michael J., and Hagelberg, Erika
- Published
- 1998
45. Staphylococcus aureus colonisation and its relationship with skin and soft tissue infection in New Zealand children
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Hobbs, Mark R., Grant, Cameron C., Thomas, Mark G., Berry, Sarah, Morton, Susan M. B., Marks, Emma, and Ritchie, Stephen R.
- Published
- 2018
- Full Text
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46. Dense sampling of ethnic groups within African countries reveals fine-scale genetic structure and extensive historical admixture
- Author
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Bird, Nancy, primary, Ormond, Louise, additional, Awah, Paschal, additional, Caldwell, Elizabeth F., additional, Connell, Bruce, additional, Elamin, Mohamed, additional, Fadlelmola, Faisal M., additional, Matthew Fomine, Forka Leypey, additional, López, Saioa, additional, MacEachern, Scott, additional, Moñino, Yves, additional, Morris, Sam, additional, Näsänen-Gilmore, Pieta, additional, Nketsia V, Nana Kobina, additional, Veeramah, Krishna, additional, Weale, Michael E., additional, Zeitlyn, David, additional, Thomas, Mark G., additional, Bradman, Neil, additional, and Hellenthal, Garrett, additional
- Published
- 2023
- Full Text
- View/download PDF
47. Dense sampling of ethnic groups within African countries reveals fine-scale genetic structure and extensive historical admixture
- Author
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Bird, Nancy, Ormond, Louise, Awah, Paschal, Caldwell, Elizabeth F, Connell, Bruce, Elamin, Mohamed, Fadlelmola, Faisal M, Matthew Fomine, Forka Leypey, López, Saioa, MacEachern, Scott, Moñino, Yves, Morris, Sam, Näsänen-Gilmore, Pieta, Nketsia V, Nana Kobina, Veeramah, Krishna, Weale, Michael E, Zeitlyn, David, Thomas, Mark G, Bradman, Neil, Hellenthal, Garrett, Bird, Nancy, Ormond, Louise, Awah, Paschal, Caldwell, Elizabeth F, Connell, Bruce, Elamin, Mohamed, Fadlelmola, Faisal M, Matthew Fomine, Forka Leypey, López, Saioa, MacEachern, Scott, Moñino, Yves, Morris, Sam, Näsänen-Gilmore, Pieta, Nketsia V, Nana Kobina, Veeramah, Krishna, Weale, Michael E, Zeitlyn, David, Thomas, Mark G, Bradman, Neil, and Hellenthal, Garrett
- Abstract
Previous studies have highlighted how African genomes have been shaped by a complex series of historical events. Despite this, genome-wide data have only been obtained from a small proportion of present-day ethnolinguistic groups. By analyzing new autosomal genetic variation data of 1333 individuals from over 150 ethnic groups from Cameroon, Republic of the Congo, Ghana, Nigeria, and Sudan, we demonstrate a previously underappreciated fine-scale level of genetic structure within these countries, for example, correlating with historical polities in western Cameroon. By comparing genetic variation patterns among populations, we infer that many northern Cameroonian and Sudanese groups share genetic links with multiple geographically disparate populations, likely resulting from long-distance migrations. In Ghana and Nigeria, we infer signatures of intermixing dated to over 2000 years ago, corresponding to reports of environmental transformations possibly related to climate change. We also infer recent intermixing signals in multiple African populations, including Congolese, that likely relate to the expansions of Bantu language-speaking peoples.
- Published
- 2023
48. Statistically robust representation and comparison of mortality profiles in archaeozoology
- Author
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Gerbault, Pascale, Gillis, Rosalind, Vigne, Jean-Denis, Tresset, Anne, Bréhard, Stéphanie, and Thomas, Mark G.
- Published
- 2016
- Full Text
- View/download PDF
49. Early Neolithic genomes from the eastern Fertile Crescent
- Author
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Broushaki, Farnaz, Thomas, Mark G., Link, Vivian, López, Saioa, van Dorp, Lucy, Kirsanow, Karola, Hofmanová, Zuzana, Diekmann, Yoan, Cassidy, Lara M., Díez-del-Molino, David, Kousathanas, Athanasios, Sell, Christian, Robson, Harry K., Martiniano, Rui, Blöcher, Jens, Scheu, Amelie, Kreutzer, Susanne, Bollongino, Ruth, Bobo, Dean, Davoudi, Hossein, Munoz, Olivia, Currat, Mathias, Abdi, Kamyar, Biglari, Fereidoun, Craig, Oliver E., Bradley, Daniel G., Shennan, Stephen, Veeramah, Krishna R., Mashkour, Marjan, Wegmann, Daniel, Hellenthal, Garrett, and Burger, Joachim
- Published
- 2016
50. Early farmers from across Europe directly descended from Neolithic Aegeans
- Author
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Hofmanová, Zuzana, Kreutzer, Susanne, Hellenthal, Garrett, Sell, Christian, Diekmann, Yoan, Díez-del-Molino, David, van Dorp, Lucy, López, Saioa, Kousathanas, Athanasios, Link, Vivian, Kirsanow, Karola, Cassidy, Lara M., Martiniano, Rui, Strobel, Melanie, Scheu, Amelie, Kotsakis, Kostas, Halstead, Paul, Triantaphyllou, Sevi, Kyparissi-Apostolika, Nina, Urem-Kotsou, Dushka, Ziota, Christina, Adaktylou, Fotini, Gopalan, Shyamalika, Bobo, Dean M., Winkelbach, Laura, Blöcher, Jens, Unterländer, Martina, Leuenberger, Christoph, Çilingiroğlu, Çiler, Horejs, Barbara, Gerritsen, Fokke, Shennan, Stephen J., Bradley, Daniel G., Currat, Mathias, Veeramah, Krishna R., Wegmann, Daniel, Thomas, Mark G., Papageorgopoulou, Christina, and Burger, Joachim
- Published
- 2016
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