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402 results on '"Tholouli, Eleni"'

1. Improved outcome of COVID-19 over time in patients treated with CAR T-cell therapy: Update of the European COVID-19 multicenter study on behalf of the European Society for Blood and Marrow Transplantation (EBMT) Infectious Diseases Working Party (IDWP) and the European Hematology Association (EHA) Lymphoma Group

Author

Spanjaart, Anne Mea, Ljungman, Per, Tridello, Gloria, Schwartz, Juana, Martinez-Cibrián, Nuria, Barba, Pere, Kwon, Mi, Lopez-Corral, Lucia, Martinez-Lopez, Joaquin, Ferra, Christelle, Di Blasi, Roberta, Ghesquieres, Hervé, Mutsaers, Pim, Calkoen, Friso, Jak, Margot, van Doesum, Jaap, Vermaat, Joost S. P., van der Poel, Marjolein, Maertens, Johan, Gambella, Massimiliano, Metafuni, Elisabetta, Ciceri, Fabio, Saccardi, Riccardo, Nicholson, Emma, Tholouli, Eleni, Matthew, Collin, Potter, Victoria, Bloor, Adrian, Besley, Caroline, Roddie, Claire, Wilson, Keith, Nagler, Arnon, Campos, Antonio, Petersen, Soeren Lykke, Folber, Frantisek, Bader, Peter, Finke, Jurgen, Kroger, Nicolaus, Knelange, Nina, de La Camara, Rafael, Kersten, Marie José, and Mielke, Stephan

Published
2024
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2. In the era of Bortezomib-based Induction, intensification of Melphalan-based conditioning with Bortezomib does not improve Survival Outcomes in newly diagnosed Multiple Myeloma: a study from the Chronic Malignancies Working Party of the EBMT

Author

Beksac, Meral, Eikema, Diderik-Jan, Koster, Linda, Hulin, Cyrille, Poiré, Xavier, Hamladji, Rose-Marie, Gromek, Tomasz, Bazarbachi, Ali, Ozkurt, Zubeyde Nur, Pabst, Thomas, Ben Othman, Tarek, Finke, Jürgen, Pirogova, Olga, Wu, Depei, Hayat, Amjad, Hilgendorf, Inken, Tholouli, Eleni, de Wreede, Liesbeth C., Schönland, Stefan, Garderet, Laurent, Drozd-Sokolowska, Joanna, Raj, Kavita, Hayden, Patrick J., Yakoub-Agha, Ibrahim, and McLornan, Donal P.

Published
2024
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4. Comparison of fludarabine/melphalan (FluMel) with fludarabine/melphalan/BCNU or thiotepa (FBM/FTM) in patients with AML in first complete remission undergoing allogeneic hematopoietic stem cell transplantation – a registry study on behalf of the EBMT Acute Leukemia Working Party

Author

Duque-Afonso, Jesús, Finke, Jürgen, Ngoya, Maud, Galimard, Jacques-Emmanuel, Craddock, Charles, Raj, Kavita, Bloor, Adrian, Nicholson, Emma, Eder, Matthias, Kim, Orchard, Valerius, Thomas, Snowden, John A., Tholouli, Eleni, Crawley, Charles, Collin, Matthew, Wilson, Keith M. O., Gadisseur, Alain, Protheroe, Rachel, Wagner-Drouet, Eva Maria, Savani, Bipin N., Spyridonidis, Alexandros, Ciceri, Fabio, Nagler, Arnon, and Mohty, Mohamad

Published
2024
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5. Allogeneic hematopoietic cell transplantation for patients with AML aged 70 years or older in first remission. A study from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation (EBMT)

Author

Maffini, Enrico, Ngoya, Maud, Galimard, Jacques-Emmanuel, Harbi, Samia, Kröger, Nicolaus, Platzbecker, Uwe, Sengeloev, Henrik, Craddock, Charles, Potter, Victoria, Choi, Goda, Chevallier, Patrice, Stölzel, Friedrich, Tholouli, Eleni, Maertens, Johan, Ciceri, Fabio, Cornelissen, Jan, Sanz, Jaime, Spyridonidis, Alexandros, Lanza, Francesco, Nagler, Arnon, and Mohty, Mohamad

Published
2023
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6. Alternative donor transplantation for severe aplastic anemia: a comparative study of the SAAWP EBMT

Author

Montoro, Juan, Eikema, Dirk-Jan, Tuffnell, Joe, Potter, Victoria, Kalwak, Krzysztof, Halkes, Constantijn J. M., Kulagin, Alexander, Collin, Matthew, Wynn, Robert F., Robinson, Stephen, Nicholson, Emma, Sengeloev, Henrik, Clay, Jennifer, Halahleh, Khalid, Skorobogatova, Elena, Sanz, Jaime, Passweg, Jakob, Mielke, Stephan, Ryhänen, Samppa, Carpenter, Ben, Gedde-Dahl, Tobias, Tholouli, Eleni, Fanin, Renato, Lewalle, Philippe, Kulasekararaj, Austin, Risitano, Antonio, and Peffault de Latour, Régis

Published
2024
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8. Posttransplant MRD and T-cell chimerism status predict outcomes in patients who received allografts for AML/MDS

Author

Loke, Justin, McCarthy, Nicholas, Jackson, Aimee, Siddique, Shamyla, Hodgkinson, Andrea, Mason, John, Crawley, Charles, Gilleece, Maria, Peniket, Andrew, Protheroe, Rachel, Salim, Rahuman, Tholouli, Eleni, Wilson, Keith, Andrew, Georgia, Dillon, Richard, Khan, Naeem, Potter, Victoria, Krishnamurthy, Pramila, Craddock, Charles, and Freeman, Sylvie

Published
2023
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10. Dual targeting of CD19 and CD22 with bicistronic CAR-T cells in patients with relapsed/refractory large B-cell lymphoma

Author

Roddie, Claire, Lekakis, Lazaros J., Marzolini, Maria A. V., Ramakrishnan, Aravind, Zhang, Yiyun, Hu, Yanqing, Peddareddigari, Vijay G. R., Khokhar, Nushmia, Chen, Robert, Basilico, Silvia, Raymond, Meera, Vargas, Frederick Arce, Duffy, Kevin, Brugger, Wolfram, O’Reilly, Maeve A., Wood, Leigh, Linch, David C., Peggs, Karl S., Bachier, Carlos, Budde, Elizabeth Lihua, Lee Batlevi, Connie, Bartlett, Nancy, Irvine, David, Tholouli, Eleni, Osborne, Wendy, Ardeshna, Kirit M., and Pule, Martin A.

Published
2023
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11. Comparison of fludarabine–melphalan and fludarabine–treosulfan as conditioning prior to allogeneic hematopoietic cell transplantation—a registry study on behalf of the EBMT Acute Leukemia Working Party

Author

Duque-Afonso, Jesus, Finke, Jürgen, Labopin, Myriam, Craddock, Charles, Protheroe, Rachel, Kottaridis, Panagiotis, Tholouli, Eleni, Byrne, Jenny L., Orchard, Kim, Salmenniemi, Urpu, Hilgendorf, Inken, Hunter, Hannah, Nicholson, Emma, Bloor, Adrian, Snowden, John A., Verbeek, Mareike, Clark, Andrew, Savani, Bipin N., Spyridonidis, Alexandros, Nagler, Arnon, and Mohty, Mohamad

Published
2022
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12. Obecabtagene autoleucel (obe-cel, AUTO1) in adults with relapsed/refractory B-cell acute lymphoblastic leukemia (R/R B-ALL): Overall survival (OS), event-free survival (EFS) and the potential impact of chimeric antigen receptor (CAR)-T cell persistency and consolidative stem cell transplantation (SCT) in the open-label, single-arm FELIX phase Ib/II study.

Author

Jabbour, Elias, primary, Tholouli, Eleni, additional, Sandhu, Karamjeet S., additional, Shaughnessy, Paul, additional, Barba, Pere, additional, Guerreiro, Manuel, additional, Yallop, Deborah, additional, Logan, Aaron, additional, Abedi, Mehrdad, additional, Lao-Sirieix, Pierre, additional, Zhang, Yiyun, additional, Brugger, Wolfram, additional, Pule, Martin A., additional, Shah, Bijal D., additional, Bishop, Michael Russell, additional, Park, Jae H., additional, DeAngelo, Daniel J., additional, Peggs, Karl, additional, and Roddie, Claire, additional

Published
2024
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15. Human Leukocyte Antigen Mismatching and Survival in Contemporary Hematopoietic Cell Transplantation for Hematologic Malignancies.

Author

Arrieta-Bolaños, Esteban, Bonneville, Edouard F., Crivello, Pietro, Robin, Marie, Gedde-Dahl, Tobias, Salmenniemi, Urpu, Kröger, Nicolaus, Yakoub-Agha, Ibrahim, Crawley, Charles, Choi, Goda, Broers, Annoek E.C., Forcade, Edouard, Carre, Martin, Poiré, Xavier, Huynh, Anne, Lenhoff, Stig, Ciceri, Fabio, Tholouli, Eleni, Schroeder, Thomas, and Deconinck, Eric

Published
2024
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17. HLA Mismatching and Transplant Outcome in the Ptcy Era: A Comprehensive Study By the EBMT Cellular Therapy and Immunobiology Working Party

Author

Bolaños, Esteban Arrieta, primary, Bonneville, Edouard F, additional, Robin, Marie, additional, Gedde-Dahl, Tobias, additional, Salmenniemi, Urpu, additional, Kröger, Nicolaus, additional, Yakoub-Agha, Ibrahim, additional, Crawley, Charles, additional, Choi, Goda, additional, Broers, Annoek EC, additional, Forcade, Edouard, additional, Carre, Martin, additional, Poiré, Xavier, additional, Huynh, Anne, additional, Remenyi, Peter, additional, Lenhoff, Stig, additional, Ciceri, Fabio, additional, Tholouli, Eleni, additional, Schroeder, Thomas, additional, Deconinck, Eric, additional, Carlson, Kristina Elisabet, additional, de Wreede, Liesbeth C, additional, Hoogenboom, Jorinde, additional, Malard, Florent, additional, Ruggeri, Annalisa, additional, and Fleischhauer, Katharina, additional

Published
2024
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19. Autologous stem cell transplantation for post-transplant lymphoproliferative disorders after solid organ transplantation: a retrospective analysis from the Lymphoma Working Party of the EBMT

Author

Eyre, Toby A., Caillard, Sophie, Finel, Herve, Boumendil, Ariane, Kothari, Jaimal, Zimmermann, Heiner, Trappe, Ralf Ulrich, De Wilde, Virginie, Tholouli, Eleni, Kanfer, Edward, Broom, Angus, Damaj, Gandhi, Bargetzi, Mario, Kozák, Tomáš, Hilgendorf, Inken, Crawley, Charles, Kerre, Tessa, Trněný, Marek, Bachy, Emmanuel, Robinson, Stephen, and Montoto, Silvia

Published
2021
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20. Gilteritinib as Post-Transplant Maintenance for Acute Myeloid Leukemia With Internal Tandem Duplication Mutation of FLT3

Author

Levis, M, Hamadani, M, Logan, B, Jones, R, Singh, A, Litzow, M, Wingard, J, Papadopoulos, E, Perl, A, Soiffer, R, Ustun, C, Ueda Oshima, M, Uy, G, Waller, E, Vasu, S, Solh, M, Mishra, A, Muffly, L, Kim, H, Mikesch, J, Najima, Y, Onozawa, M, Thomson, K, Nagler, A, Wei, A, Marcucci, G, Geller, N, Hasabou, N, Delgado, D, Rosales, M, Hill, J, Gill, S, Nuthethi, R, King, D, Wittsack, H, Mendizabal, A, Devine, S, Horowitz, M, Chen, Y, Agura, E, Altman, J, Anagnostopoulos, A, Anand, S, Artz, A, Aulitzky, W, Balderman, S, Ballen, K, Becker, M, Beguin, Y, Berkahn, L, Berneman, Z, Bhatt, V, Bilmon, I, Bonifazi, F, Briggs, A, Bruno, B, Brunstein, C, Byrne, M, Byrne, J, Cabrero, M, Cairoli, R, Carrum, G, Cerny, J, Cheong, J, Ciceri, F, Colorado, M, Cook, R, Couriel, D, Craddock, C, Damon, L, Deol, A, Desbrosses, Y, Di Grazia, C, Di Stasi, A, Dias, A, Dorritie, K, Essell, J, Eto, T, Farag, S, Forcade, E, Frankfurt, O, Fujiwara, S, Fukuda, T, Fukushima, K, Furst, S, Goto, T, Hall, A, Hatta, S, Hicheri, Y, Horwitz, M, Hou, H, How, J, Howard, D, Hsu, W, Huynh, A, Irvine, D, Ishikawa, T, Jamieson, K, Jedrzejczak, W, Jethava, Y, Jimenez, A, Jung, C, Kanda, J, Karakasis, D, Kato, J, Kekre, N, Khera, N, Klein, A, Kobbe, G, Kornblit, B, Kota, V, Lachance, S, Leber, B, Lee, C, Lee, J, Lin, T, Liu, T, Martelli, M, Martinez, C, Matsuoka, K, Mccarty, J, Mendez, L, Michelis, F, Mineishi, S, Mohty, M, Moors, I, Motyckova, G, Mueller, L, Nakamae, H, Nakano, N, Nathan, S, Nicholson, E, Norkin, M, Ogawa, Y, Olesen, G, Oluwole, O, Pantin, J, Paulson, K, Pemberton, L, Perera, T, Piatkowska-Jakubas, B, Poire, X, Protheroe, R, Rambaldi, A, Ritchie, D, Ross, K, Rubio, M, Santarone, S, Sanz Caballer, J, Sawa, M, Schaar, D, Scheid, C, Schriber, J, Seropian, S, Shah, N, Shore, T, Gil, J, Sobecks, R, Socie, G, Sprague, K, Spyridonidis, A, Stelljes, M, Stiff, P, Stuart, R, Tanaka, M, Tandra, A, Tholouli, E, Thomas, X, Tiribelli, M, Tomlinson, B, Tsirigotis, P, Tzachanis, D, Uchida, N, Ueda, M, Valcarcel Ferreiras, D, Wagner, E, Watson, A, Weisdorf, D, Wolschke, C, Wrobel, T, Yakoub-Agha, I, Yamauchi, T, Yared, J, Yeh, S, Yoon, S, Yoshihara, S, Null, N, Levis, Mark J., Hamadani, Mehdi, Logan, Brent, Jones, Richard J., Singh, Anurag K., Litzow, Mark, Wingard, John R., Papadopoulos, Esperanza B., Perl, Alexander E., Soiffer, Robert J., Ustun, Celalettin, Ueda Oshima, Masumi, Uy, Geoffrey L., Waller, Edmund K., Vasu, Sumithra, Solh, Melhem, Mishra, Asmita, Muffly, Lori, Kim, Hee-Je, Mikesch, Jan-Henrik, Najima, Yuho, Onozawa, Masahiro, Thomson, Kirsty, Nagler, Arnon, Wei, Andrew H., Marcucci, Guido, Geller, Nancy L., Hasabou, Nahla, Delgado, David, Rosales, Matt, Hill, Jason, Gill, Stanley C., Nuthethi, Rishita, King, Denise, Wittsack, Heather, Mendizabal, Adam, Devine, Steven M., Horowitz, Mary M., Chen, Yi-Bin, Agura, Ed, Altman, Jessica, Anagnostopoulos, Achiles, Anand, Sarah, Artz, Andrew, Aulitzky, Walter, Balderman, Sophia, Ballen, Karen, Becker, Michael, Beguin, Yves, Berkahn, Leanne, Berneman, Zwi, Bhatt, Vijaya, Bilmon, Ian, Bonifazi, Francesca, Briggs, Adrienne, Bruno, Benedetto, Brunstein, Claudio, Byrne, Michael, Byrne, Jenny, Cabrero, Monica, Cairoli, Roberto, Carrum, George, Cerny, Jan, Cheong, June-Won, Ciceri, Fabio, Colorado, Mercedes, Cook, Rachel, Couriel, Daniel, Craddock, Charles, Damon, Lloyd, Deol, Abhinav, Desbrosses, Yohan, Devine, Steve, Di Grazia, Carmela, Di Stasi, Antonio, Dias, Ajoy, Dorritie, Kathy, Essell, James, Eto, Tetsuya, Farag, Sherif, Forcade, Edouard, Frankfurt, Olga, Fujiwara, Shinichiro, Fukuda, Takahiro, Fukushima, Kentaro, Furst, Sabine, Goto, Tatsunori, Hall, Aric, Hatta, Shunsuke, Hicheri, Yosr, Horwitz, Mitchell, Hou, Hsin-An, How, Jonathan, Howard, Dianna, Hsu, Wei-Hsun (Blake), Huynh, Anne, Irvine, David, Ishikawa, Takayuki, Jamieson, Katarzyna, Jedrzejczak, Wieslaw, Jethava, Yogesh, Jimenez, Antonio, Jung, Chul Won, Kanda, Junya, Karakasis, Dimitrios, Kato, Jun, Kekre, Natasha, Khera, Nandita, Klein, Andreas, Kobbe, Guido, Kornblit, Brian, Kota, Vamsi, Lachance, Silvy, Leber, Brian, Lee, Catherine, Lee, Je Hwan, Lin, Tung-Liang, Liu, Ta-Chih, Martelli, Maurizio, Martinez, Carmen, Matsuoka, Kenichi, McCarty, John, Mendez, Lourdes, Michelis, Fotios, Mineishi, Shin, Mohty, Mohamad, Moors, Ine, Motyckova, Gabriela, Mueller, Lutz, Nakamae, Hirohisa, Nakano, Nobuaki, Nathan, Sunita, Nicholson, Emma, Norkin, Maxim, Ogawa, Yoshiaki, Olesen, Gitte, Oluwole, Olalekan, Pantin, Jeremy, Paulson, Kristjan, Pemberton, Lucy, Perera, Travis, Piatkowska-Jakubas, Beata, Poire, Xavier, Protheroe, Rachel, Rambaldi, Alessandro, Ritchie, David, Ross, Kelly, Rubio, Marie-Therese, Santarone, Stella, Sanz Caballer, Jaime, Sawa, Masashi, Schaar, Dale, Scheid, Christoph, Schriber, Jeffrey, Seropian, Stuart, Shah, Nilay, Shah, Nirav, Shore, Tsiporah, Gil, Jorge Sierra, Singh, Anurag, Sobecks, Ronald, Socie, Gerard, Soiffer, Robert, Sprague, Kellie, Spyridonidis, Alexandros, Stelljes, Matthias, Stiff, Patrick, Stuart, Robert, Tanaka, Masatsugu, Tandra, Anand, Tholouli, Eleni, Thomas, Xavier, Tiribelli, Mario, Tomlinson, Benjamin, Tsirigotis, Panagiotis, Tzachanis, Dimitrios, Uchida, Naoyuki, Ueda, Masumi, Valcarcel Ferreiras, David, Wagner, Eva, Watson, Anne-Marie, Weisdorf, Daniel, Wolschke, Christine, Wrobel, Tomasz, Yakoub-Agha, Ibrahim, Yamauchi, Takuji, Yared, Jean, Yeh, Su-Peng, Yoon, Sung-Soo, Yoshihara, Satoshi, null, null, Levis, M, Hamadani, M, Logan, B, Jones, R, Singh, A, Litzow, M, Wingard, J, Papadopoulos, E, Perl, A, Soiffer, R, Ustun, C, Ueda Oshima, M, Uy, G, Waller, E, Vasu, S, Solh, M, Mishra, A, Muffly, L, Kim, H, Mikesch, J, Najima, Y, Onozawa, M, Thomson, K, Nagler, A, Wei, A, Marcucci, G, Geller, N, Hasabou, N, Delgado, D, Rosales, M, Hill, J, Gill, S, Nuthethi, R, King, D, Wittsack, H, Mendizabal, A, Devine, S, Horowitz, M, Chen, Y, Agura, E, Altman, J, Anagnostopoulos, A, Anand, S, Artz, A, Aulitzky, W, Balderman, S, Ballen, K, Becker, M, Beguin, Y, Berkahn, L, Berneman, Z, Bhatt, V, Bilmon, I, Bonifazi, F, Briggs, A, Bruno, B, Brunstein, C, Byrne, M, Byrne, J, Cabrero, M, Cairoli, R, Carrum, G, Cerny, J, Cheong, J, Ciceri, F, Colorado, M, Cook, R, Couriel, D, Craddock, C, Damon, L, Deol, A, Desbrosses, Y, Di Grazia, C, Di Stasi, A, Dias, A, Dorritie, K, Essell, J, Eto, T, Farag, S, Forcade, E, Frankfurt, O, Fujiwara, S, Fukuda, T, Fukushima, K, Furst, S, Goto, T, Hall, A, Hatta, S, Hicheri, Y, Horwitz, M, Hou, H, How, J, Howard, D, Hsu, W, Huynh, A, Irvine, D, Ishikawa, T, Jamieson, K, Jedrzejczak, W, Jethava, Y, Jimenez, A, Jung, C, Kanda, J, Karakasis, D, Kato, J, Kekre, N, Khera, N, Klein, A, Kobbe, G, Kornblit, B, Kota, V, Lachance, S, Leber, B, Lee, C, Lee, J, Lin, T, Liu, T, Martelli, M, Martinez, C, Matsuoka, K, Mccarty, J, Mendez, L, Michelis, F, Mineishi, S, Mohty, M, Moors, I, Motyckova, G, Mueller, L, Nakamae, H, Nakano, N, Nathan, S, Nicholson, E, Norkin, M, Ogawa, Y, Olesen, G, Oluwole, O, Pantin, J, Paulson, K, Pemberton, L, Perera, T, Piatkowska-Jakubas, B, Poire, X, Protheroe, R, Rambaldi, A, Ritchie, D, Ross, K, Rubio, M, Santarone, S, Sanz Caballer, J, Sawa, M, Schaar, D, Scheid, C, Schriber, J, Seropian, S, Shah, N, Shore, T, Gil, J, Sobecks, R, Socie, G, Sprague, K, Spyridonidis, A, Stelljes, M, Stiff, P, Stuart, R, Tanaka, M, Tandra, A, Tholouli, E, Thomas, X, Tiribelli, M, Tomlinson, B, Tsirigotis, P, Tzachanis, D, Uchida, N, Ueda, M, Valcarcel Ferreiras, D, Wagner, E, Watson, A, Weisdorf, D, Wolschke, C, Wrobel, T, Yakoub-Agha, I, Yamauchi, T, Yared, J, Yeh, S, Yoon, S, Yoshihara, S, Null, N, Levis, Mark J., Hamadani, Mehdi, Logan, Brent, Jones, Richard J., Singh, Anurag K., Litzow, Mark, Wingard, John R., Papadopoulos, Esperanza B., Perl, Alexander E., Soiffer, Robert J., Ustun, Celalettin, Ueda Oshima, Masumi, Uy, Geoffrey L., Waller, Edmund K., Vasu, Sumithra, Solh, Melhem, Mishra, Asmita, Muffly, Lori, Kim, Hee-Je, Mikesch, Jan-Henrik, Najima, Yuho, Onozawa, Masahiro, Thomson, Kirsty, Nagler, Arnon, Wei, Andrew H., Marcucci, Guido, Geller, Nancy L., Hasabou, Nahla, Delgado, David, Rosales, Matt, Hill, Jason, Gill, Stanley C., Nuthethi, Rishita, King, Denise, Wittsack, Heather, Mendizabal, Adam, Devine, Steven M., Horowitz, Mary M., Chen, Yi-Bin, Agura, Ed, Altman, Jessica, Anagnostopoulos, Achiles, Anand, Sarah, Artz, Andrew, Aulitzky, Walter, Balderman, Sophia, Ballen, Karen, Becker, Michael, Beguin, Yves, Berkahn, Leanne, Berneman, Zwi, Bhatt, Vijaya, Bilmon, Ian, Bonifazi, Francesca, Briggs, Adrienne, Bruno, Benedetto, Brunstein, Claudio, Byrne, Michael, Byrne, Jenny, Cabrero, Monica, Cairoli, Roberto, Carrum, George, Cerny, Jan, Cheong, June-Won, Ciceri, Fabio, Colorado, Mercedes, Cook, Rachel, Couriel, Daniel, Craddock, Charles, Damon, Lloyd, Deol, Abhinav, Desbrosses, Yohan, Devine, Steve, Di Grazia, Carmela, Di Stasi, Antonio, Dias, Ajoy, Dorritie, Kathy, Essell, James, Eto, Tetsuya, Farag, Sherif, Forcade, Edouard, Frankfurt, Olga, Fujiwara, Shinichiro, Fukuda, Takahiro, Fukushima, Kentaro, Furst, Sabine, Goto, Tatsunori, Hall, Aric, Hatta, Shunsuke, Hicheri, Yosr, Horwitz, Mitchell, Hou, Hsin-An, How, Jonathan, Howard, Dianna, Hsu, Wei-Hsun (Blake), Huynh, Anne, Irvine, David, Ishikawa, Takayuki, Jamieson, Katarzyna, Jedrzejczak, Wieslaw, Jethava, Yogesh, Jimenez, Antonio, Jung, Chul Won, Kanda, Junya, Karakasis, Dimitrios, Kato, Jun, Kekre, Natasha, Khera, Nandita, Klein, Andreas, Kobbe, Guido, Kornblit, Brian, Kota, Vamsi, Lachance, Silvy, Leber, Brian, Lee, Catherine, Lee, Je Hwan, Lin, Tung-Liang, Liu, Ta-Chih, Martelli, Maurizio, Martinez, Carmen, Matsuoka, Kenichi, McCarty, John, Mendez, Lourdes, Michelis, Fotios, Mineishi, Shin, Mohty, Mohamad, Moors, Ine, Motyckova, Gabriela, Mueller, Lutz, Nakamae, Hirohisa, Nakano, Nobuaki, Nathan, Sunita, Nicholson, Emma, Norkin, Maxim, Ogawa, Yoshiaki, Olesen, Gitte, Oluwole, Olalekan, Pantin, Jeremy, Paulson, Kristjan, Pemberton, Lucy, Perera, Travis, Piatkowska-Jakubas, Beata, Poire, Xavier, Protheroe, Rachel, Rambaldi, Alessandro, Ritchie, David, Ross, Kelly, Rubio, Marie-Therese, Santarone, Stella, Sanz Caballer, Jaime, Sawa, Masashi, Schaar, Dale, Scheid, Christoph, Schriber, Jeffrey, Seropian, Stuart, Shah, Nilay, Shah, Nirav, Shore, Tsiporah, Gil, Jorge Sierra, Singh, Anurag, Sobecks, Ronald, Socie, Gerard, Soiffer, Robert, Sprague, Kellie, Spyridonidis, Alexandros, Stelljes, Matthias, Stiff, Patrick, Stuart, Robert, Tanaka, Masatsugu, Tandra, Anand, Tholouli, Eleni, Thomas, Xavier, Tiribelli, Mario, Tomlinson, Benjamin, Tsirigotis, Panagiotis, Tzachanis, Dimitrios, Uchida, Naoyuki, Ueda, Masumi, Valcarcel Ferreiras, David, Wagner, Eva, Watson, Anne-Marie, Weisdorf, Daniel, Wolschke, Christine, Wrobel, Tomasz, Yakoub-Agha, Ibrahim, Yamauchi, Takuji, Yared, Jean, Yeh, Su-Peng, Yoon, Sung-Soo, Yoshihara, Satoshi, and null, null

Abstract

Purpose: Allogeneic hematopoietic cell transplantation (HCT) improves outcomes for patients with acute myeloid leukemia (AML) harboring an internal tandem duplication mutation of FLT3 (FLT3-ITD) AML. These patients are routinely treated with a FLT3 inhibitor after HCT, but there is limited evidence to support this. Accordingly, we conducted a randomized trial of post-HCT maintenance with the FLT3 inhibitor gilteritinib (ClinicalTrials.gov identifier: NCT02997202) to determine if all such patients benefit or if detection of measurable residual disease (MRD) could identify those who might benefit. Methods: Adults with FLT3-ITD AML in first remission underwent HCT and were randomly assigned to placebo or 120 mg once daily gilteritinib for 24 months after HCT. The primary end point was relapse-free survival (RFS). Secondary end points included overall survival (OS) and the effect of MRD pre- and post-HCT on RFS and OS. Results: Three hundred fifty-six participants were randomly assigned post-HCT to receive gilteritinib or placebo. Although RFS was higher in the gilteritinib arm, the difference was not statistically significant (hazard ratio [HR], 0.679 [95% CI, 0.459 to 1.005]; two-sided P = .0518). However, 50.5% of participants had MRD detectable pre- or post-HCT, and, in a prespecified subgroup analysis, gilteritinib was beneficial in this population (HR, 0.515 [95% CI, 0.316 to 0.838]; P = .0065). Those without detectable MRD showed no benefit (HR, 1.213 [95% CI, 0.616 to 2.387]; P = .575). Conclusion: Although the overall improvement in RFS was not statistically significant, RFS was higher for participants with detectable FLT3-ITD MRD pre- or post-HCT who received gilteritinib treatment. To our knowledge, these data are among the first to support the effectiveness of MRD-based post-HCT therapy.

Published
2024

21. Chimeric antigen receptor T cell therapy: a new emerging landscape in autoimmune rheumatic diseases.

Author

Lyu, Xia, Gupta, Latika, Tholouli, Eleni, and Chinoy, Hector

Subjects
PATIENT selection, T cells, PATIENT safety, IMMUNOTHERAPY, CELLULAR therapy, DISEASE remission, ANTIGENS, AUTOIMMUNE diseases, DRUG efficacy, CELL receptors, RHEUMATISM
Abstract

Chimeric antigen receptor T cell (CAR-T) therapy, an innovative immune cell therapy, has revolutionized the treatment landscape of haematological malignancies. The past 2 years has witnessed the successful application of CD19-targeting CAR constructs in refractory cases of autoimmune rheumatic diseases, including systemic lupus erythematosus, systemic sclerosis and anti-synthetase syndrome. In comparison with existing B cell depletion therapies, targeting CD19 has demonstrated a more rapid and profound therapeutic effect, enabling drug-free remission with manageable adverse events. These promising results necessitate validation through long-term, large-sample randomized controlled studies. Corroborating the role of CAR-T therapy in refractory rheumatological disorders and affirming safety, efficacy and durability of responses are the aims of future clinical studies. Optimizing the engineering strategies and better patient selection are also critical to further refining the successful clinical implementation of CAR-T therapy. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Role of HLA-B exon 1 in graft-versus-host disease after unrelated haemopoietic cell transplantation: a retrospective cohort study

Author

Petersdorf, Effie W, Carrington, Mary, O'hUigin, Colm, Bengtsson, Mats, De Santis, Dianne, Dubois, Valerie, Gooley, Ted, Horowitz, Mary, Hsu, Katharine, Madrigal, J Alejandro, Maiers, Martin, Malkki, Mari, McKallor, Caroline, Morishima, Yasuo, Oudshoorn, Machteld, Spellman, Stephen, Villard, Jean, Stevenson, Phil, Apperley, Jane, Bardy, Peter, Bernard, Ghislaine, Bertrand, Yves, Bloor, Adrian, Bonini, Chiara, Buhler, Stephane, Bungener, Laura, Campbell, Helen, Carlson, Kristina, Carpenter, Ben, Cesbron, Anne, Chabannon, Christian, Chalandon, Yves, Chapman, Jeremy, Chebel, Réda, Chevallier, Patrice, Choi, Gerda, Collin, Matt, Cornelissen, Jan J, Crawley, Charles, D'Orsogna, Lloyd, Dalle, Jean-Hugues, Deconinck, Eric, DeMatteis, Muriel, Diviney, Mary, Dormoy, Anne, Gagne, Katia, Gibson, Brenda, Gilleece, Maria, Gottlieb, David, Gribben, John, Güngör, Tayfun, Haagenson, Mike, Hart, Cathie, Holdsworth, Rhonda, Humphreys, Ian, Kodera, Yoshihisa, Koh, Mickey, Labussière-Wallet, Hélène, Lankester, Arjan C, Lardy, Neubery, Lawson, Sarah, Leleu, Xavier, MacKinnon, Stephen, Malladi, Ram, Marsh, Steven GE, Martin, Murray, Mayor, Neema P, McQuaker, I Grant, Meijer, Ellen, Morishima, Satoko, Nikolousis, Emmanouil, Orchard, Kim, Passweg, Jacob, Patel, Amit, Patrick, Katherine, Pedron, Béatrice, Peniket, Andy, Perry, Julia, Petersen, Eefke, Potter, Victoria, Potter, Mike, Protheroe, Rachel, Raus, Nicole, Ruiz de Elvira, Carmen, Russell, Nigel, Schaap, Nicholaas PM, Schanz, Urs, Schouten, Harry, Skinner, Roderick, Snowden, John, Spierings, Eric, Steward, Colin, Tholouli, Eleni, Thornton, Alycia, Tilanus, Marcel, van de Meer, Arnold, Veelkens, Hendrik, Veys, Paul, Watson, Narelle, Weston, Lyanne, Wilson, Keith, Wilson, Marie, Wynn, Robert, Zsiros, József, Maiers, Martin J, and Spellman, Stephen R

Published
2020
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23. Fludarabine, Cytarabine, Granulocyte Colony-Stimulating Factor, and Idarubicin With Gemtuzumab Ozogamicin Improves Event-Free Survival in Younger Patients With Newly Diagnosed AML and Overall Survival in Patients With NPM1 and FLT3 Mutations

Author

Russell, Nigel H., primary, Wilhelm-Benartzi, Charlotte, additional, Othman, Jad, additional, Dillon, Richard, additional, Knapper, Steven, additional, Batten, Leona M., additional, Canham, Joanna, additional, Hinson, Emily L., additional, Betteridge, Sophie, additional, Overgaard, Ulrik Malthe, additional, Gilkes, Amanda, additional, Potter, Nicola, additional, Mehta, Priyanka, additional, Kottaridis, Panagiotis, additional, Cavenagh, Jamie, additional, Hemmaway, Claire, additional, Arnold, Claire, additional, Freeman, Sylvie D., additional, Dennis, Mike, additional, Kallenbach, Maria, additional, Severinsen, Marianne, additional, Holm, Mette, additional, Maxwell Norgaard, Jan, additional, Beier Ommen, Hans, additional, Culligan, Dominic, additional, Tighe, Jane, additional, Craig, Jenny, additional, Crawley, Charles, additional, Krishnamurthy, Pramila, additional, Sadik, Walid, additional, Smith, Jeffery, additional, Dasgupta, Ranjit, additional, Berkhan, Leanne, additional, Bowett, Peter, additional, Doocey, Richard, additional, Emmett, Shannon, additional, Hawkins, Timothy, additional, Patton, Nigel, additional, Pemberton, Lucy, additional, Milne, Alison, additional, Roy, Ashok, additional, Simpson, Sylwia, additional, Cuthbert, Robert, additional, Finnegan, Damian, additional, Francis McMullin, Mary, additional, Pechey, Victoria, additional, Lovell, Richard, additional, Milligan, Donald, additional, Paneesha, Shankara, additional, Cahalin, Paul, additional, Kelsey, P., additional, Ackroyd, Sam, additional, Wiliams, Adrian, additional, Evely, Roger, additional, Marks, David, additional, Fletcher, Andrew, additional, Al-Ani, Maryam, additional, Ahmed, Khalil, additional, Lush, Richard, additional, Rye, Adam, additional, Cutting, Robert, additional, Welch, Emma, additional, Wodzinski, Mark, additional, Butler, Andrew, additional, Fernyhough, Liam, additional, Ganly, Peter, additional, Gibbons, Steve, additional, Smith, Mark, additional, Spearing, Ruth, additional, Peniket, Andy, additional, Hatcliffe, Faye, additional, Patel, Amit, additional, Lindsay, Kathrine, additional, Brearton, Gillian, additional, Tuegar, Salah, additional, Gandhi Anna Cowley, S., additional, Copplestone, Adrian, additional, Hunter, Hannah, additional, Medd, Patrick, additional, Nokes, Tim, additional, Rule, Simon, additional, Thomas, Wayne, additional, Joseph, Joe, additional, Kaul, Stuti, additional, Sorour, Youssef, additional, Chvuka, Shingi, additional, Mangos, Hilda, additional, Neylon, Annette, additional, Farrell, Katrina, additional, Edwards, Hugh, additional, Hanlon, Katharine, additional, Fail, Tom, additional, Goodrick, Margaret, additional, Heartin, Earnest, additional, Hoyle, Christine, additional, Carr, Robert, additional, Raj, Kavita, additional, Krogh Jensen, Morten, additional, Janmohamed, Riaz, additional, Kaczmarski, Richard, additional, Sugai, Taku, additional, Ademokun, Debo, additional, Chalmers, Isobel, additional, Hodson, Andrew, additional, Gomez, Cesar, additional, Sadullah, Shala, additional, Kwan, Mark, additional, Longmuir, Karyn, additional, Wilson-Morkeh, Isaac, additional, Hunter, Ann, additional, Martin, Murray, additional, Saravanamuttu, Kandeepan, additional, Sidra, Gamal, additional, Burns, Sarah, additional, Gibbs, Simon, additional, Tholouli, Eleni, additional, Aldouri, Maadh, additional, Andrews, Vivienne, additional, Eden, Ayed, additional, Dungarwalla, Moez, additional, White, Denise, additional, Laird, Jane, additional, Mitchell, Lindsey, additional, Murphy, John, additional, Paterson, Pamela, additional, Raafat, Alaeddin, additional, Mannari, Deepak, additional, Davies, Simon, additional, Austen, Belinda, additional, Allford, Sarah, additional, Kakalamudi, Sudhakar, additional, Basu, Supratik, additional, Hada, Sunil, additional, Jacob, Abraham, additional, MacWhonell, Alan, additional, McCaig, Alison, additional, Gelly, Keith, additional, Kerr, Ron, additional, Meiklejohn, David, additional, Tauro, Sudhir, additional, Lawes, Matthew, additional, Bowen, Angela, additional, Krishnamurthy, Suchitra, additional, Byrne, Jenny, additional, Dasgupta, Emma, additional, Russell, Nigel, additional, Stokley, Simone, additional, Friis, Lone, additional, Marcher, Claus, additional, Bake, Bart, additional, Chapple, Mary, additional, Moreton, Paul, additional, Omran, Asad, additional, Patil, Kavita, additional, Wright, David, additional, Jack, Fergus, additional, Maddams, Rebecca, additional, Corser, Robert, additional, Cranfield, Tanya, additional, Dignum, Helen, additional, Ganczakowski, Mary, additional, Jones, Christopher, additional, Craddock, Charles, additional, Moss, Paula, additional, Murray, Jim, additional, Craig, Joanne, additional, Forsyth, Peter, additional, Lush, Chris, additional, Wei Bjerrum, Ole, additional, Borregaard, Niels, additional, Kampmann, Peter, additional, Kjeldsen, Lars, additional, Juul Nielsen, Ove, additional, Niemann, Carsten, additional, Lykke Petersen, Soeren, additional, Udby Peter Møller, Lene, additional, Alfred, Arun, additional, Barker, Helen, additional, Went, Richard, additional, Groch, Henri, additional, Mucklow, Stuart, additional, Sampson, Rebecca, additional, Chacko, Joseph, additional, Hall, Rachel, additional, Walewska, Renata, additional, Creach, Desmond, additional, Pottinger, Bryson, additional, Addada, Juanah (Jo), additional, Hamilton, Malcolm, additional, Kerr, Paul, additional, Ngu, Loretta, additional, Rudin, Claudius, additional, Ruell, Jackie, additional, Dalley, Chris, additional, Kaur, Harpreet, additional, Reilly, John, additional, Snowden, John, additional, Ferguson, Paul, additional, Dyer, Peter, additional, Chandra, Deepak, additional, DeVos, Johannes, additional, Grey-Davies, Elisabeth, additional, Hendry, Louise, additional, Corbett, Timothy, additional, Crowe, Josephine, additional, Knechtli, Christopher, additional, Wexler, Sarah, additional, Fernandes, Savio, additional, Neilson, Jeff, additional, Houghton, John, additional, Jowitt, Simon, additional, Thomas-Dewing, Rowena, additional, Williams, Mark, additional, Zaman, Sonya, additional, Cullis, Jonathan, additional, Everington, Tamara, additional, Grand, Effie, additional, Hasan, Yasmin, additional, Murrin, Richard, additional, Wandoo, Farooq, additional, Ismail, Saad, additional, Mohite, Unmesh, additional, Sati, Hamdi, additional, Jenner, Matthew, additional, Orchard, Kim, additional, Richardson, Deborah, additional, McCloskey, Kayleigh, additional, Xu Chin, Kate, additional, Fenella Willis, Neoh, additional, Sud, Amit, additional, Gharib, Maged, additional, Nicholson, Toby, additional, Bowen, David, additional, Janes, Sarah, additional, Eagleton, Helen, additional, O'Hea, Anne-Marie, additional, Pattinson, Jonathan, additional, Hervey, Victoria, additional, Lyons, Simon, additional, Marshall, Scott, additional, Nicolle, Annette, additional, Vavyla, Maria, additional, Burgess, Jordan, additional, Somervaille, Tim, additional, Somerfield, Sven, additional, Mamat, Mohd, additional, Tomlins, Jo, additional, Salesh, Sana, additional, David, Marianna, additional, Maddox, Jamie, additional, Plews, Diane, additional, Dang, Ray, additional, Potter, Mike, additional, Ellis, Lauren, additional, Nicholson, Emma, additional, Keat, Sally, additional, Ahmed Alhassani, Thubeena M., additional, Anjum, Farahn, additional, Chatterjee, Poulami, additional, Stanchev, Atanas, additional, Peters, Jayne, additional, Lindsay-Holmes Srividhya, Sarah, additional, Chodhouri, Senthil S., additional, Eve, Heather, additional, Smith, Steve, additional, Roberts, Patrick, additional, Rymes, Nicholas, additional, Zhao New Oo, Rui, additional, Ardeshna, Kirit, additional, Blombery, Piers, additional, Khwaja, Asim, additional, Linch, David, additional, Popat, Rakesh, additional, Virchis, Andres, additional, Yong, Kwee, additional, McIntyre, Victoria, additional, Horne, Gillian, additional, Bokhari, Syed, additional, Borg, Anton, additional, Chapman, Oliver, additional, Harrison, Beth, additional, Jackson, Nicholas, additional, Jobanputra, Shailesh, additional, Narayanan, Mekkali, additional, Rose, Peter, additional, Oun, Hajer, additional, Powell, Matthew, additional, Gilles, Julie, additional, Laing, Alison, additional, Devanny, Ian, additional, Haskins, Lea, additional, Micallef-Eynaud, Paul, additional, Maclean, Peter, additional, Alvares, Caroline, additional, Kell, Jonathan, additional, Knapper, Steve, additional, Davidson, Kerri, additional, McLintock, Lorna, additional, Rogers, Stephen, additional, Williamson, Peter, additional, Corbett, Gillian, additional, Goodman, Hugh, additional, Islam, Shahid, additional, Pullon, Humphrey, additional, Johnson, Peter, additional, Roddie, P.H., additional, Maughan, Elizabeth, additional, Mills, Juliet, additional, Shafeek, Salim, additional, Narat, Santosh, additional, Aitchison, Robin, additional, Bond, Lee, additional, Munro, Laura, additional, and Edwards, David, additional

Published
2024
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24. Complex karyotype but not other cytogenetic abnormalities is associated with worse posttransplant survival of patients with nucleophosmin 1‐mutated acute myeloid leukemia: A study from the European Society for Blood and Marrow Transplantation Acute Leukemia Working Party

Author

Moukalled, Nour, primary, Labopin, Myriam, additional, Versluis, Jurjen, additional, Socié, Gérard, additional, Blaise, Didier, additional, Salmenniemi, Urpu, additional, Rambaldi, Alessandro, additional, Gedde‐Dahl, Tobias, additional, Tholouli, Eleni, additional, Kröger, Nicolaus, additional, Bourhis, Jean‐Henri, additional, Von Dem Borne, Peter, additional, Daguindau, Etienne, additional, Forcade, Edouard, additional, Nagler, Arnon, additional, Esteve, Jordi, additional, Ciceri, Fabio, additional, Bazarbachi, Ali, additional, and Mohty, Mohamad, additional

Published
2024
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25. Comparison of fludarabine/melphalan (FluMel) with fludarabine/melphalan/BCNU or thiotepa (FBM/FTM) in patients with AML in first complete remission undergoing allogeneic hematopoietic stem cell transplantation – a registry study on behalf of the EBMT Acute Leukemia Working Party

Author

Duque-Afonso, Jesús, primary, Finke, Jürgen, additional, Ngoya, Maud, additional, Galimard, Jacques-Emmanuel, additional, Craddock, Charles, additional, Raj, Kavita, additional, Bloor, Adrian, additional, Nicholson, Emma, additional, Eder, Matthias, additional, Kim, Orchard, additional, Valerius, Thomas, additional, Snowden, John A., additional, Tholouli, Eleni, additional, Crawley, Charles, additional, Collin, Matthew, additional, Wilson, Keith M. O., additional, Gadisseur, Alain, additional, Protheroe, Rachel, additional, Wagner-Drouet, Eva Maria, additional, Savani, Bipin N., additional, Spyridonidis, Alexandros, additional, Ciceri, Fabio, additional, Nagler, Arnon, additional, and Mohty, Mohamad, additional

Published
2023
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27. Presence of donor-encoded centromeric KIR B content increases the risk of infectious mortality in recipients of myeloablative, T-cell deplete, HLA-matched HCT to treat AML

Author

Bultitude, Will P., Schellekens, Jennifer, Szydlo, Richard M., Anthias, Chloe, Cooley, Sarah A., Miller, Jeffrey S., Weisdorf, Daniel J., Shaw, Bronwen E., Roberts, Chrissy h., Garcia-Sepulveda, Christian A., Lee, Julia, Pearce, Rachel M., Wilson, Marie C., Potter, Michael N., Byrne, Jenny L., Russell, Nigel H., MacKinnon, Stephen, Bloor, Adrian J., Patel, Amit, McQuaker, I. Grant, Malladi, Ram, Tholouli, Eleni, Orchard, Kim, Potter, Victoria T., Madrigal, J. Alejandro, Mayor, Neema P., and Marsh, Steven G. E.

Published
2020
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28. Reducing the diversity of allogeneic transplant protocols in the UK through a BSBMT Anthony Nolan Protocol Harmonization Initiative

Author

Anthias, Chloe, Apperley, Jane, Bloor, Adrian, Byrne, Jennifer, Collin, Matthew, Crawley, Charles, Craddock, Charles, Finnegan, Damian, Gilleece, Maria, Gribben, John, Hunter, Ann, Hunter, Hannah, Koh, Mickey, Mackinnon, Stephen, Malladi, Ram, Marks, David, McQuaker, Grant, Nikolousis, Manos, Orchard, Kim, Pavlu, Jiri, Peniket, Andrew, Potter, Mike, Potter, Victoria, Robinson, Stephen, Russell, Nigel, Salim, Rahuman, Snowden, John, Thomson, Kirsty, Tholouli, Eleni, and Wilson, Keith

Published
2020
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29. Allogeneic Stem Cell Transplantation for Blast Crisis Chronic Myeloid Leukemia in the Era of Tyrosine Kinase Inhibitors: A Retrospective Study by the EBMT Chronic Malignancies Working Party

Author

Radujkovic, Aleksandar, Dietrich, Sascha, Blok, Henric-Jan, Nagler, Arnon, Ayuk, Francis, Finke, Jürgen, Tischer, Johanna, Mayer, Jiri, Koc, Yener, Sorà, Federica, Passweg, Jakob, Byrne, Jenny L., Jindra, Pavel, Veelken, Joan Hendrik, Socié, Gerard, Maertens, Johan, Schaap, Nicolaas, Stadler, Michael, Itälä-Remes, Maija, Tholouli, Eleni, Arat, Mutlu, Rocha, Vanderson, Ljungman, Per, Yakoub-Agha, Ibrahim, Kröger, Nicolaus, and Chalandon, Yves

Published
2019
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32. Improved COVID-19 outcomes in CAR-T patients in the age of vaccination and preemptive pharmacotherapeutics

Author

Cheok, Kathleen P. L., primary, Kirkwood, Amy A., additional, Creasey, Thomas, additional, Tholouli, Eleni, additional, Chaganti, Sridhar, additional, Mathew, Amrith, additional, Dulobdas, Vaishali, additional, Irvine, David, additional, Besley, Caroline, additional, Neil, Lorna, additional, Lown, Robert, additional, Menne, Tobias, additional, Townsend, William, additional, Kuhnl, Andrea, additional, O’Reilly, Maeve, additional, Sanderson, Robin, additional, Sanchez, Emilie, additional, and Roddie, Claire, additional

Published
2023
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34. S262: SAFETY AND EFFICACY OF OBECABTAGENE AUTOLEUCEL (OBE-CEL), A FAST-OFF RATE CD19 CAR IN RELAPSED/REFRACTORY ADULT B-CELL ACUTE LYMPHOBLASTIC LEUKAEMIA:TOP LINE RESULTS OF THE PIVOTAL FELIX STUDY

Author

Roddie, Claire, primary, Sandhu, Karamjeet, additional, Tholouli, Eleni, additional, Shaughnessy, Paul, additional, Barba Suñol, Pere, additional, Nuno Direito de Morais Guerreiro, Manuel, additional, Abedi, Mehrdad, additional, Bishop, Michael, additional, Yared, Jean, additional, Ghobadi, Armin, additional, Yallop, Deborah, additional, Logan, Aaron, additional, Amer, Beitinjaneh, additional, Pantin, Jeremy, additional, Arellano, Martha L, additional, Chaganti, Sridhar, additional, Malladi, Ram, additional, Menne, Tobias, additional, Escamilla, Virginia, additional, Hodby, Katharine, additional, Gundabolu, Krishna, additional, Mountjoy, Luke, additional, Odwyer, Kristen, additional, Abedin, Sameem, additional, Alkhateeb, Hassan, additional, Shah, Bijal, additional, Basilico, Silvia, additional, Cluxton, Deborah, additional, Dawes, Joanna, additional, Lao-Sirieix, Pierre, additional, Raymond, Meera, additional, Shang, Justin, additional, Hu, Yanqing, additional, Pittari, Gianfranco, additional, Saxena, Kapil, additional, Brugger, Wolfram, additional, Zhang, Y, additional, Pule, Martin, additional, Park, Daniel, additional, De Angelo, Daniel, additional, and Jabbour, Elias, additional

Published
2023
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37. Directionality of HLA-DP permissive mismatches improves risk prediction in HCT for acute leukemia and MDS

Author

Arrieta-Bolaños, Esteban, van der Burg, Lars L. J., Gedde-Dahl, Tobias, Robin, Marie, Salmenniemi, Urpu, Kröger, Nicolaus, Yakoub-Agha, Ibrahim, Huynh, Anne, Crawley, Charles, Deconinck, Eric, Bulabois, Claude Eric, Forcade, Edouard, Tholouli, Eleni, van der Hem, Joost G. K., van Balen, Peter, Hoogenboom, Jorinde D., de Wreede, Liesbeth C., Malard, Florent, Ruggeri, Annalisa, and Fleischhauer, Katharina

Published
2024
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38. Integrating biological HLA-DPB1 mismatch models to predict survival after unrelated hematopoietic cell transplantation

Author

Ruggeri, Annalisa, De Wreede, Liesbeth C, Müller, Carlheinz R, Crivello, Pietro, Bonneville, Edouard F, Petersdorf, Effie W, Socié, Gerard, Dubois, Valérie, Niittyvuopio, Riitta, Peräsaari, Juha, Yakoub-Agha, Ibrahim, Cornelissen, Jan J, Wieten, Lotte, Gedde-Dahl, Tobias, Forcade, Edouard, Crawley, Charles R, Marsh, Steven G E, Gandemer, Virginie, Tholouli, Eleni, Bulabois, Claude-Eric, Huynh, Anne, Choi, Goda, Deconinck, Eric, Itäla-Remes, Maija, Lenhoff, Stig, Bengtsson, Mats, Johansson, Jan-Erik, Van Gorkom, Gwendolyn, Hoogenboom, Jorinde D, Vago, Luca, Rocha, Vanderson, Bonini, Chiara, Chabannon, Christian, Fleischhauer, Katharina, Ruggeri, Annalisa, De Wreede, Liesbeth C, Müller, Carlheinz R, Crivello, Pietro, Bonneville, Edouard F, Petersdorf, Effie W, Socié, Gerard, Dubois, Valérie, Niittyvuopio, Riitta, Peräsaari, Juha, Yakoub-Agha, Ibrahim, Cornelissen, Jan J, Wieten, Lotte, Gedde-Dahl, Tobias, Forcade, Edouard, Crawley, Charles R, Marsh, Steven G E, Gandemer, Virginie, Tholouli, Eleni, Bulabois, Claude-Eric, Huynh, Anne, Choi, Goda, Deconinck, Eric, Itäla-Remes, Maija, Lenhoff, Stig, Bengtsson, Mats, Johansson, Jan-Erik, Van Gorkom, Gwendolyn, Hoogenboom, Jorinde D, Vago, Luca, Rocha, Vanderson, Bonini, Chiara, Chabannon, Christian, and Fleischhauer, Katharina

Published
2023
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39. Immunotherapy with CD25/CD71-allodepleted T cells to improve T-cell reconstitution after matched unrelated donor hematopoietic stem cell transplant: a randomized trial

Author

Peggs, Karl S., primary, Albon, Sarah J., additional, Oporto Espuelas, Macarena, additional, Irving, Catherine, additional, Richardson, Rachel, additional, Casanovas-Company, Joan, additional, Wallace, Rebecca, additional, Guvenel, Aleks, additional, Ghorashian, Sara, additional, Collura, Angela, additional, Subramaniyam, Meera, additional, Flutter, Barry, additional, Popova, Bilyana, additional, Castro, Fernanda, additional, Lopes, Andre, additional, Champion, Kim, additional, Schofield, Oliver, additional, Clifton-Hadley, Laura, additional, Taylor, Thomas, additional, Farrell, Maria, additional, Adams, Stuart, additional, Gilmour, Kimberly C., additional, Mackinnon, Stephen, additional, Tholouli, Eleni, additional, and Amrolia, Persis J., additional

Published
2023
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40. First in Human Study of AUTO4, a TRBC1-Targeting CAR T-Cell Therapy in Relapsed/Refractory TRBC1-Positive Peripheral T-Cell Lymphoma

Author

Cwynarski, Kate, primary, Iacoboni, Gloria, additional, Tholouli, Eleni, additional, Menne, Tobias F., additional, Irvine, David A., additional, Balasubramaniam, Nivetha, additional, Wood, Leigh, additional, Shang, Justin, additional, Zhang, Yiyun, additional, Basilico, Silvia, additional, Huber, Birgit, additional, Vinson, Mary, additional, Lilova, Koki, additional, Brugger, Wolfram, additional, and Pule, Martin, additional

Published
2022
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41. Comparison of Fludarabine/Melphalan (FluMel) with Fludarabine/Melphalan/BCNU or Thiotepa (FBM/FTM) in Patients with AML in First Complete Remission Undergoing Allogeneic Hematopoietic Stem Cell Transplantation - a Registry Study on Behalf of the EBMT Acute Leukemia Working Party

Author

Duque Afonso, Jesus, primary, Finke, Jürgen, additional, Ngoya, Maud, additional, Galimard, Jacques-Emmanuel, additional, Craddock, Charles, additional, Raj, Kavita, additional, Bloor, Adrian, additional, Nicholson, Emma, additional, Eder, Matthias, additional, Orchard, Kim H., additional, Valerius, Thomas, additional, Snowden, John A., additional, Tholouli, Eleni, additional, Crawley, Charles, additional, Collin, Matthew P., additional, Wilson, Keith, additional, Gadisseur, Alain, additional, Protheroe, Rachel Elizabeth, additional, Wagner, Eva Maria, additional, Savani, Bipin, additional, Spyridonidis, Alexandros, additional, Ciceri, Fabio, additional, Nagler, Arnon, additional, and Mohty, Mohamad, additional

Published
2022
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42. Characteristics and outcomes of patients with acute promyelocytic leukemia and extreme hyperleukocytosis at presentation

Author

Iland, Harry J., Russell, Nigel, Dillon, Richard, Schuh, Andre C., Tedjaseputra, Aditya, Wei, Andrew, Khwaja, Asim, Knapper, Steven, Lane, Steven W., Reynolds, John, McMullin, Mary Frances, Martin, Annalise, Tan, Peter, Taussig, David C., Wong, Anny, Taper, John, Fraga, Christina, Kelly, Richard, Tawana, Kiran, Mehta, Priyanka, Mina, Alain, Altman, Jessica K., Mølle, Ingolf, Tauro, Sudhir, and Tholouli, Eleni

Published
2023
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44. Comparison of fludarabine/melphalan (FluMel) with fludarabine/melphalan/BCNU or thiotepa (FBM/FTM) in patients with AML in first complete remission undergoing allogeneic hematopoietic stem cell transplantation – a registry study on behalf of the EBMT Acute Leukemia Working Party.

Author

Duque-Afonso, Jesus, primary, Finke, Jürgen, additional, Ngoya, Maud, additional, Galimard, Jacques-Emmanuel, additional, Craddock, Charles, additional, Raj, Kavita, additional, Bloor, Adrian, additional, Nicholson, Emma, additional, Eder, Matthias, additional, Kim, Orchard, additional, Valerius, Thomas, additional, Snowden, John, additional, Tholouli, Eleni, additional, Crawley, Charles, additional, Collin, Matthew, additional, Wilson, Keith, additional, Gadisseur, Alain, additional, Protheroe, Rachel, additional, Wagner-Drouet, Eva, additional, Savani, Bipin, additional, Spyridonidis, Alexandros, additional, Ciceri, Fabio, additional, Nagler, Arnon, additional, and Mohty, Mohamad, additional

Published
2022
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45. Characteristics and outcomes of patients with acute promyelocytic leukemia and extreme hyperleukocytosis at presentation

Author

Iland, Harry J, primary, Russell, Nigel H., additional, Dillon, Richard, additional, Schuh, Andre C., additional, Tedjaseputra, Aditya, additional, Wei, Andrew H., additional, Khwaja, Asim, additional, Knapper, Steven, additional, Lane, Steven W, additional, Reynolds, John, additional, McMullin, Mary Frances Frances, additional, Martin, Annalise Maria, additional, Tan, Peter, additional, Taussig, David Christopher C, additional, Wong, Anny, additional, Taper, John M, additional, Fraga, Christina, additional, Kelly, Richard, additional, Tawana, Kiran, additional, Mehta, Priyanka, additional, Mina, Alain, additional, Altman, Jessica K., additional, Mølle, Ingolf, additional, Tauro, Sudhir, additional, and Tholouli, Eleni, additional

Published
2022
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46. Successful provision of CAR-T therapy during a pandemic: low SARS-CoV-2 infection rates and reduction in ICU admissions following modification of patient pathway

Author

Carter-Brzezinski, Luke, primary, Davies, Elizabeth, additional, Norman, Jane, additional, Rubio, Lourdes, additional, Dixon, Christopher, additional, Brett, Sarah, additional, Dunne, Tony, additional, Iqbal, Shahid, additional, Dignan, Fiona L., additional, Ahmad, Shazaad, additional, Machin, Nicholas, additional, Morriss, Henry, additional, Wilson, Anthony, additional, and Tholouli, Eleni, additional

Published
2022
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47. The evolution of cellular deficiency in GATA2 mutation

Author

Dickinson, Rachel E., Milne, Paul, Jardine, Laura, Zandi, Sasan, Swierczek, Sabina I., McGovern, Naomi, Cookson, Sharon, Ferozepurwalla, Zaveyna, Langridge, Alexander, Pagan, Sarah, Gennery, Andrew, Heiskanen-Kosma, Tarja, Hämäläinen, Sari, Seppänen, Mikko, Helbert, Matthew, Tholouli, Eleni, Gambineri, Eleonora, Reykdal, Sigrún, Gottfreðsson, Magnús, Thaventhiran, James E., Morris, Emma, Hirschfield, Gideon, Richter, Alex G., Jolles, Stephen, Bacon, Chris M., Hambleton, Sophie, Haniffa, Muzlifah, Bryceson, Yenan, Allen, Carl, Prchal, Josef T., Dick, John E., Bigley, Venetia, and Collin, Matthew

Published
2014
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48. UK consensus statement on the use of plerixafor to facilitate autologous peripheral blood stem cell collection to support high‐dose chemoradiotherapy for patients with malignancy

Author

Douglas, Kenneth W., Gilleece, Maria, Hayden, Patrick, Hunter, Hannah, Johnson, Peter R. E., Kallmeyer, Charlotte, Malladi, Ram K., Paneesha, Shankara, Pawson, Rachel, Quinn, Michael, Raj, Kavita, Richardson, Deborah, Robinson, Stephen, Russell, Nigel, Snowden, John, Sureda, Anna, Tholouli, Eleni, Thomson, Kirsty, Watts, Mike, and Wilson, Keith M.

Published
2018
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49. Integrating biological HLA-DPB1 mismatch models to predict survival after unrelated hematopoietic cell transplantation

Author

Ruggeri, Annalisa, primary, De Wreede, Liesbeth C., additional, Müller, Carlheinz R., additional, Crivello, Pietro, additional, Bonneville, Edouard F., additional, Petersdorf, Effie W., additional, Socié, Gerard, additional, Dubois, Valérie, additional, Niittyvuopio, Riitta, additional, Peräsaari, Juha, additional, Yakoub-Agha, Ibrahim, additional, Cornelissen, Jan J., additional, Wieten, Lotte, additional, Gedde-Dahl, Tobias, additional, Forcade, Edouard, additional, Crawley, Charles R., additional, Marsh, Steven G.E., additional, Gandemer, Virginie, additional, Tholouli, Eleni, additional, Bulabois, Claude-Eric, additional, Huynh, Anne, additional, Choi, Goda, additional, Deconinck, Eric, additional, Itäla-Remes, Maija, additional, Lenhoff, Stig, additional, Bengtsson, Mats, additional, Johansson, Jan-Erik, additional, Van Gorkom, Gwendolyn, additional, Hoogenboom, Jorinde D., additional, Vago, Luca, additional, Rocha, Vanderson, additional, Bonini, Chiara, additional, Chabannon, Christian, additional, and Fleischhauer, Katharina, additional

Published
2022
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50. Measurable residual disease, FLT3-ITD mutation, and disease status have independent prognostic influence on outcome of allogeneic stem cell transplantation in NPM1-mutated acute myeloid leukemia.

Author

UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Centre du cancer, UCL - (SLuc) Service d'hématologie, Al Hamed, Rama, Labopin, Myriam, Daguindau, Etienne, Niittyvuopio, Riitta, Huynh, Anne, Socié, Gerard, Srour, Micha, Henri Bourhis, Jean, Kröger, Nicolaus, Tholouli, Eleni, Choi, Goda, Poiré, Xavier, Martin, Hans, Rubio, Marie-Thérèse, Jindra, Pavel, Blaise, Didier, Beelen, Dietrich, Labussière-Wallet, Hélène, Nagler, Arnon, Bazarbachi, Ali, Mohty, Mohamad, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Centre du cancer, UCL - (SLuc) Service d'hématologie, Al Hamed, Rama, Labopin, Myriam, Daguindau, Etienne, Niittyvuopio, Riitta, Huynh, Anne, Socié, Gerard, Srour, Micha, Henri Bourhis, Jean, Kröger, Nicolaus, Tholouli, Eleni, Choi, Goda, Poiré, Xavier, Martin, Hans, Rubio, Marie-Thérèse, Jindra, Pavel, Blaise, Didier, Beelen, Dietrich, Labussière-Wallet, Hélène, Nagler, Arnon, Bazarbachi, Ali, and Mohty, Mohamad

Abstract

Nucleophosmin-1 (NPM1) mutations in acute myeloid leukemia (AML) confer a survival advantage in the absence of FLT3-internal tandem duplication (FLT3-ITD). Here, we investigated the main predictors of outcome after allogeneic hematopoietic stem cell transplantation (allo-HCT). We identified 1572 adult (age ≥ 18 year) patients with NPM1-mutated AML in first complete remission (CR1:78%) or second complete remission (CR2:22%) who were transplanted from matched sibling donors (30.8%) or unrelated donors (57.4%) between 2007 and 2019 at EBMT participating centers. Median follow-up for survivors was 23.7 months. FLT3-ITD was present in 69.3% of patients and 39.2% had detectable minimal/measurable residual disease (MRD) at transplant. In multivariate analysis, relapse incidence (RI) and leukemia-free survival (LFS) were negatively affected by concomitant FLT3-ITD mutation (HR 1.66 p = 0.0001, and HR 1.53, p < 0.0001, respectively), MRD positivity at transplant (HR 2.18, p < 10 and HR 1.71, p < 10 , respectively), and transplant in CR2 (HR 1.36, p = 0.026, and HR 1.26, p = 0.033, respectively), but positively affected by Karnofsky score ≥90 (HR 0.74, p = 0.012, and HR 0.7, p = 0.0002, respectively). Overall survival (OS) was also negatively influenced by concomitant FLT3-ITD (HR 1.6, p = 0.0001), MRD positivity at transplant (HR 1.61, p < 10 ), and older age (HR 1.22 per 10 years, p < 0.0001), but positively affected by matched sibling donor (unrelated donor: HR 1.35, p = 0.012; haploidentical donor: HR 1.45, p = 0.037) and Karnofsky score ≥90 (HR 0.73, p = 0.004). These results highlight the independent and significant role of FLT3-ITD, MRD status, and disease status on posttransplant outcomes in patients with NPM1-mutated AML allowing physicians to identify patients at risk of relapse who may benefit from posttransplant prophylactic interventions.

Published
2022

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