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499 results on '"Thoeny, Harriet"'

1. Definition and Diagnosis of Oligometastatic Bladder Cancer: A Delphi Consensus Study Endorsed by the European Association of Urology, European Society for Radiotherapy and Oncology, and European Society of Medical Oncology Genitourinary Faculty

Author

Bamias, Aristotelis, Stenzl, Arnulf, Brown, Stephanie L., Albiges, Laurence, Babjuk, Marko, Birtle, Alison, Briganti, Alberto, Burger, Maximilian, Choudhury, Ananya, Colecchia, Maurizio, De Santis, Maria, Fanti, Stefano, Fonteyne, Valérie, Gallucci, Michele, Rivas, Juan Gómez, Huddart, Robert, Junker, Kerstin, Kroeze, Stephanie, Loriot, Yohann, Merseburger, Axel, Montironi, Rodolfo, Necchi, Andrea, Oing, Christoph, Oldenburg, Jan, Ost, Piet, Pinkawa, Michael, Ribal, Maria J., Rouprêt, Morgan, Thoeny, Harriet, Zilli, Thomas, and Hoskin, Peter

Published
2023
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3. Deep Learning How to Fit an Intravoxel Incoherent Motion Model to Diffusion-Weighted MRI

Author

Barbieri, Sebastiano, Gurney-Champion, Oliver J., Klaassen, Remy, and Thoeny, Harriet C.

Subjects
Quantitative Biology - Quantitative Methods, Computer Science - Machine Learning, Electrical Engineering and Systems Science - Image and Video Processing
Abstract

Purpose: This prospective clinical study assesses the feasibility of training a deep neural network (DNN) for intravoxel incoherent motion (IVIM) model fitting to diffusion-weighted magnetic resonance imaging (DW-MRI) data and evaluates its performance. Methods: In May 2011, ten male volunteers (age range: 29 to 53 years, mean: 37 years) underwent DW-MRI of the upper abdomen on 1.5T and 3.0T magnetic resonance scanners. Regions of interest in the left and right liver lobe, pancreas, spleen, renal cortex, and renal medulla were delineated independently by two readers. DNNs were trained for IVIM model fitting using these data; results were compared to least-squares and Bayesian approaches to IVIM fitting. Intraclass Correlation Coefficients (ICC) were used to assess consistency of measurements between readers. Intersubject variability was evaluated using Coefficients of Variation (CV). The fitting error was calculated based on simulated data and the average fitting time of each method was recorded. Results: DNNs were trained successfully for IVIM parameter estimation. This approach was associated with high consistency between the two readers (ICCs between 50 and 97%), low intersubject variability of estimated parameter values (CVs between 9.2 and 28.4), and the lowest error when compared with least-squares and Bayesian approaches. Fitting by DNNs was several orders of magnitude quicker than the other methods but the networks may need to be re-trained for different acquisition protocols or imaged anatomical regions. Conclusion: DNNs are recommended for accurate and robust IVIM model fitting to DW-MRI data. Suitable software is available at (1).

Published
2019
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4. Consensus-based technical recommendations for clinical translation of renal BOLD MRI.

Author

Bane, Octavia, Mendichovszky, Iosif, Milani, Bastien, Dekkers, Ilona, Deux, Jean-Francois, Eckerbom, Per, Grenier, Nicolas, Hall, Michael, Inoue, Tsutomu, Laustsen, Christoffer, Lerman, Lilach, Morrell, Glen, Pedersen, Michael, Pruijm, Menno, Sadowski, Elizabeth, Seeliger, Erdmann, Sharma, Kanishka, Thoeny, Harriet, Vermathen, Peter, Serafin, Zbigniew, Zhang, Jeff, Francis, Susan, Sourbron, Steven, Pohlmann, Andreas, Fain, Sean, Prasad, Pottumarthi, Wang, Zhen, and Liu, Chunlei

Subjects
BOLD MRI, Biomarkers, Consensus, Imaging, Kidney, Standardization, Animals, Biomarkers, Consensus, Delphi Technique, Humans, Kidney, Magnetic Resonance Imaging, Reproducibility of Results, Signal-To-Noise Ratio, Surveys and Questionnaires, Translational Research, Biomedical
Abstract

Harmonization of acquisition and analysis protocols is an important step in the validation of BOLD MRI as a renal biomarker. This harmonization initiative provides technical recommendations based on a consensus report with the aim to move towards standardized protocols that facilitate clinical translation and comparison of data across sites. We used a recently published systematic review paper, which included a detailed summary of renal BOLD MRI technical parameters and areas of investigation in its supplementary material, as the starting point in developing the survey questionnaires for seeking consensus. Survey data were collected via the Delphi consensus process from 24 researchers on renal BOLD MRI exam preparation, data acquisition, data analysis, and interpretation. Consensus was defined as ≥ 75% unanimity in response. Among 31 survey questions, 14 achieved consensus resolution, 12 showed clear respondent preference (65-74% agreement), and 5 showed equal (50/50%) split in opinion among respondents. Recommendations for subject preparation, data acquisition, processing and reporting are given based on the survey results and review of the literature. These technical recommendations are aimed towards increased inter-site harmonization, a first step towards standardization of renal BOLD MRI protocols across sites. We expect this to be an iterative process updated dynamically based on progress in the field.

Published
2020

5. Consensus-based technical recommendations for clinical translation of renal diffusion-weighted MRI

Author

Ljimani, Alexandra, Caroli, Anna, Laustsen, Christoffer, Francis, Susan, Mendichovszky, Iosif Alexandru, Bane, Octavia, Nery, Fabio, Sharma, Kanishka, Pohlmann, Andreas, Dekkers, Ilona A, Vallee, Jean-Paul, Derlin, Katja, Notohamiprodjo, Mike, Lim, Ruth P, Palmucci, Stefano, Serai, Suraj D, Periquito, Joao, Wang, Zhen Jane, Froeling, Martijn, Thoeny, Harriet C, Prasad, Pottumarthi, Schneider, Moritz, Niendorf, Thoralf, Pullens, Pim, Sourbron, Steven, and Sigmund, Eric E

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Kidney Disease, Biomedical Imaging, Bioengineering, Clinical Research, Algorithms, Biomarkers, Consensus, Delphi Technique, Diffusion Magnetic Resonance Imaging, Humans, Image Interpretation, Computer-Assisted, Kidney, Models, Statistical, Motion, Reproducibility of Results, Surveys and Questionnaires, Translational Research, Biomedical, Biomarker, DWI, ADC, IVIM, DTI, Nuclear Medicine & Medical Imaging
Abstract

ObjectivesStandardization is an important milestone in the validation of DWI-based parameters as imaging biomarkers for renal disease. Here, we propose technical recommendations on three variants of renal DWI, monoexponential DWI, IVIM and DTI, as well as associated MRI biomarkers (ADC, D, D*, f, FA and MD) to aid ongoing international efforts on methodological harmonization.Materials and methodsReported DWI biomarkers from 194 prior renal DWI studies were extracted and Pearson correlations between diffusion biomarkers and protocol parameters were computed. Based on the literature review, surveys were designed for the consensus building. Survey data were collected via Delphi consensus process on renal DWI preparation, acquisition, analysis, and reporting. Consensus was defined as ≥ 75% agreement.ResultsCorrelations were observed between reported diffusion biomarkers and protocol parameters. Out of 87 survey questions, 57 achieved consensus resolution, while many of the remaining questions were resolved by preference (65-74% agreement). Summary of the literature and survey data as well as recommendations for the preparation, acquisition, processing and reporting of renal DWI were provided.DiscussionThe consensus-based technical recommendations for renal DWI aim to facilitate inter-site harmonization and increase clinical impact of the technique on a larger scale by setting a framework for acquisition protocols for future renal DWI studies. We anticipate an iterative process with continuous updating of the recommendations according to progress in the field.

Published
2020

6. Correction to: Consensus-based technical recommendations for clinical translation of renal diffusion-weighted MRI

Author

Ljimani, Alexandra, Caroli, Anna, Laustsen, Christoffer, Francis, Susan, Mendichovszky, Iosif Alexandru, Bane, Octavia, Nery, Fabio, Sharma, Kanishka, Pohlmann, Andreas, Dekkers, Ilona A, Vallee, Jean-Paul, Derlin, Katja, Notohamiprodjo, Mike, Lim, Ruth P, Palmucci, Stefano, Serai, Suraj D, Periquito, Joao, Wang, Zhen Jane, Froeling, Martijn, Thoeny, Harriet C, Prasad, Pottumarthi, Schneider, Moritz, Niendorf, Thoralf, Pullens, Pim, Sourbron, Steven, and Sigmund, Eric E

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Nuclear Medicine & Medical Imaging
Abstract

The article Consensus-based technical recommendations for clinical translation of renal diffusion-weighted MRI.

Published
2020

8. Clinical indications and acquisition protocol for the use of dynamic contrast-enhanced MRI in head and neck cancer squamous cell carcinoma: recommendations from an expert panel

Author

Romeo, Valeria, Stanzione, Arnaldo, Ugga, Lorenzo, Cuocolo, Renato, Cocozza, Sirio, Quarantelli, Mario, Chawla, Sanjeev, Farina, Davide, Golay, Xavier, Parker, Geoff, Shukla-Dave, Amita, Thoeny, Harriet, Vidiri, Antonello, Brunetti, Arturo, Surlan-Popovic, Katarina, and Bisdas, Sotirios

Published
2022
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11. Imaging of Lymph Nodes

Author

Barbieri, Sebastiano, Härmä, Kirsi H., Thoeny, Harriet C., Kauczor, Hans-Ulrich, Series Editor, Parizel, Paul M., Series Editor, Peh, Wilfred C. G., Series Editor, Forstner, Rosemarie, editor, Cunha, Teresa Margarida, editor, and Hamm, Bernd, editor

Published
2019
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24. Evaluation of Organ Function

Author

de Keyzer, Frederik, Thoeny, Harriet C., Baert, A. L., editor, Reiser, M. F., editor, Hricak, H., editor, Knauth, M., editor, Koh, D. M., editor, and Thoeny, H. C., editor

Published
2010
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29. Thank You to Mentors

Author

Bluemke, David A., Andreisek, Gustav, Atri, Mostafa, Barkhof, Frederik, Davenport, Matthew, Dodd, Jonathan D., Filippi, Massimo, Goldberg, S. Nahum, Hindman, Nicole M., Iagaru, Andrei, Jara, Hernan J., Johnson, Christopher R., Kang, Stella, Link, Thomas M., Malayeri, Ashkan A., Matos, Celso, Matsui, Osumu, McCollough, Cynthia H., Mellnick, Vincent M., Newell, Mary S., Oto, Aytekin, Pagel, Mark, Paltiel, Harriet J., Scott, James A., Smith, Andrew D., Sosna, Jacob, Srinivasan, Ashok, Taylor, Stuart A., Thoeny, Harriet C., Trop, Isabelle, White, Sarah, Wortman, Jeremy R., Zaharchuk, Greg, Zins, Marc, Radiology and nuclear medicine, Amsterdam Neuroscience - Brain Imaging, and Amsterdam Neuroscience - Neuroinfection & -inflammation

Subjects
Radiology, Nuclear Medicine and imaging
Published
2022
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30. Diffusion-Weighted MRI in the Genitourinary System

Author

De Perrot, Thomas, primary, Sadjo Zoua, Christine, additional, Glessgen, Carl G., additional, Botsikas, Diomidis, additional, Berchtold, Lena, additional, Salomir, Rares, additional, De Seigneux, Sophie, additional, Thoeny, Harriet C., additional, and Vallée, Jean-Paul, additional

Published
2022
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39. PD51-09 THE VALUE OF RE-STAGING BY COMPUTED-TOMOGRAPHY (CT) TO MONITOR THE RESPONSE TO NEOADJUVANT CHEMOTHERAPY IN MUSCLE-INVASIVE BLADDER CANCER. A LONGITUDINAL LONG-TERM SINGLE CENTER STUDY

Author

Kiss, Bernhard, primary, Lütolf, Sandro, additional, Furrer, Marc A., additional, Papa, Nathan, additional, Roth, Beat, additional, Cumberbatch, Marcus, additional, Vartolomei, Mihai Dorin, additional, Thomas, Benjamin C., additional, Thoeny, Harriet C., additional, Seiler-Blarer, Roland, additional, and Thalmann, George Niklaus, additional

Published
2021
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40. Association Between Multiparametric Magnetic Resonance Imaging of the Prostate and Oncological Outcomes after Primary Treatment for Prostate Cancer: A Systematic Review and Meta-analysis

Author

Stabile, Armando, primary, Mazzone, Elio, additional, Cirulli, Giuseppe O., additional, De Cobelli, Francesco, additional, Grummet, Jeremy, additional, Thoeny, Harriet C., additional, Emberton, Mark, additional, Pokorny, Morgan, additional, Pinto, Peter A., additional, and Taneja, Samir S., additional

Published
2021
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41. A longitudinal study evaluating interim assessment of neoadjuvant chemotherapy for bladder cancer

Author

Furrer, Marc A., Papa, Nathan, Luetolf, Sandro, Roth, Beat, Cumberbatch, Marcus, Dorin Vartolomei, Mihai, Thomas, Benjamin C., Thoeny, Harriet C., Seiler, Roland, Thalmann, George N., and Kiss, Bernhard

Subjects
610 Medicine & health
Abstract

OBJECTIVES To evaluate the usefulness of radiological re-staging after two and four cycles of neoadjuvant chemotherapy (NAC), the impact of re-staging on further patient management, and the correlation between clinical and final pathological tumour stage at radical cystectomy (RC). PATIENTS AND METHODS We conducted a longitudinal, single-centre, cohort study of prospectively collected consecutive patients who underwent NAC and RC for urothelial muscle-invasive bladder cancer between July 2001 and December 2017. Patients underwent repeated computed tomography scans for re-staging after two cycles of NAC and after completion of NAC before RC. RESULTS Of 180 patients, 110 had ≥four cycles of NAC and had complete imaging available. In the entire cohort, further patient management was only changed in 2/180 patients (1.1%) after two cycles of NAC based on radiological findings. Patients who were stable after two cycles but then downstaged after at least four cycles of NAC had a similarly lowered risk of death (hazard ratio [HR] 0.53). Only one patient downstaged after two cycles was subsequently upstaged after four cycles. Clinical downstaging was observed in 51 patients (46%), 55 patients (50%) had no change in clinical stage and four patients (3.6%) were clinically upstaged. Patients clinically downstaged after four cycles of NAC had a lower risk of death (HR 0.49, 95% confidence interval 0.25-0.94; P = 0.033) compared to those with no change or upstaged after completion of NAC. CONCLUSIONS Re-staging of muscle-invasive bladder cancer after two cycles of NAC offers little additional information, rarely changes patient management, and may therefore be omitted, whereas re-staging after completion of NAC by CT is a strong predictor of overall survival.

Published
2021
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47. A longitudinal study evaluating interim assessment of neoadjuvant chemotherapy for bladder cancer.

Author

Furrer, Marc A., Papa, Nathan, Luetolf, Sandro, Roth, Beat, Cumberbatch, Marcus, Dorin Vartolomei, Mihai, Thomas, Benjamin C., Thoeny, Harriet C., Seiler, Roland, Thalmann, George N., and Kiss, Bernhard

Subjects
NEOADJUVANT chemotherapy, CANCER chemotherapy, BLADDER cancer, CANCER invasiveness, LONGITUDINAL method, URINARY diversion, ILEAL conduit surgery
Abstract

Objectives: To evaluate the usefulness of radiological re‐staging after two and four cycles of neoadjuvant chemotherapy (NAC), the impact of re‐staging on further patient management, and the correlation between clinical and final pathological tumour stage at radical cystectomy (RC). Patients and Methods: We conducted a longitudinal, single‐centre, cohort study of prospectively collected consecutive patients who underwent NAC and RC for urothelial muscle‐invasive bladder cancer between July 2001 and December 2017. Patients underwent repeated computed tomography scans for re‐staging after two cycles of NAC and after completion of NAC before RC. Results: Of 180 patients, 110 had ≥four cycles of NAC and had complete imaging available. In the entire cohort, further patient management was only changed in 2/180 patients (1.1%) after two cycles of NAC based on radiological findings. Patients who were stable after two cycles but then downstaged after at least four cycles of NAC had a similarly lowered risk of death (hazard ratio [HR] 0.53). Only one patient downstaged after two cycles was subsequently upstaged after four cycles. Clinical downstaging was observed in 51 patients (46%), 55 patients (50%) had no change in clinical stage and four patients (3.6%) were clinically upstaged. Patients clinically downstaged after four cycles of NAC had a lower risk of death (HR 0.49, 95% confidence interval 0.25–0.94; P = 0.033) compared to those with no change or upstaged after completion of NAC. Conclusions: Re‐staging of muscle‐invasive bladder cancer after two cycles of NAC offers little additional information, rarely changes patient management, and may therefore be omitted, whereas re‐staging after completion of NAC by CT is a strong predictor of overall survival. [ABSTRACT FROM AUTHOR]

Published
2022
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49. Amide proton transfer weighted imaging shows differences in multiple sclerosis lesions and white matter hyperintensities of presumed vascular origin

Author

Sartoretti, Elisabeth, Sartoretti, Thomas, Wyss, Michael, Becker, Anton S., Schwenk, Árpád, van Smoorenburg, Luuk, Najafi, Arash, Binkert, Christoph, Thoeny, Harriet C., Zhou, Jinyuan, Jiang, Shanshan, Graf, Nicole, Czell, David, Sartoretti-Schefer, Sabine, and Reischauer, Carolin

Subjects
Neurology, white matter lesions, fungi, magnetic resonance imaging, amide proton transfer, molecular imaging, multiple sclerosis lesions, CEST, Original Research
Abstract

Objectives: To assess the ability of 3D amide proton transfer weighted (APTw) imaging based on magnetization transfer analysis to discriminate between multiple sclerosis lesions (MSL) and white matter hyperintensities of presumed vascular origin (WMH) and to compare APTw signal intensity of healthy white matter (healthy WM) with APTw signal intensity of MSL and WHM. Materials and Methods: A total of 27 patients (16 female, 11 males, mean age 39.6 years) with multiple sclerosis, 35 patients (17 females, 18 males, mean age 66.6 years) with small vessel disease (SVD) and 20 healthy young volunteers (9 females, 11 males, mean age 29 years) were included in the MSL, the WMH, and the healthy WM group. MSL and WMH were segmented on fluid attenuated inversion recovery (FLAIR) images underlaid onto APTw images. Histogram parameters (mean, median, 10th, 25th, 75th, 90th percentile) were calculated. Mean APTw signal intensity values in healthy WM were defined by “Region of interest” (ROI) measurements. Wilcoxon rank sum tests and receiver operating characteristics (ROC) curve analyses of clustered data were applied. Results: All histogram parameters except the 75 and 90th percentile were significantly different between MSL and WMH (p = 0.018–p = 0.034). MSL presented with higher median values in all parameters. The histogram parameters offered only low diagnostic performance in discriminating between MSL and WMH. The 10th percentile yielded the highest diagnostic performance with an AUC of 0.6245 (95% CI: [0.532, 0.717]). Mean APTw signal intensity values of MSL were significantly higher than mean values of healthy WM (p = 0.005). The mean values of WMH did not differ significantly from the values of healthy WM (p = 0.345). Conclusions: We found significant differences in APTw signal intensity, based on straightforward magnetization transfer analysis, between MSL and WMH and between MSL and healthy WM. Low AUC values from ROC analyses, however, suggest that it may be challenging to determine type of lesion with APTw imaging. More advanced analysis of the APT CEST signal may be helpful for further differentiation of MSL and WMH., Frontiers in Neurology, 10, ISSN:1664-2295

Published
2020

50. Correction to: Consensus-based technical recommendations for clinical translation of renal diffusion-weighted MRI

Author

Highfield Research Group, Regenerative Medicine and Stem Cells, Ljimani, Alexandra, Caroli, Anna, Laustsen, Christoffer, Francis, Susan, Mendichovszky, Iosif Alexandru, Bane, Octavia, Nery, Fabio, Sharma, Kanishka, Pohlmann, Andreas, Dekkers, Ilona A, Vallee, Jean-Paul, Derlin, Katja, Notohamiprodjo, Mike, Lim, Ruth P, Palmucci, Stefano, Serai, Suraj D, Periquito, Joao, Wang, Zhen Jane, Froeling, Martijn, Thoeny, Harriet C, Prasad, Pottumarthi, Schneider, Moritz, Niendorf, Thoralf, Pullens, Pim, Sourbron, Steven, Sigmund, Eric E, Highfield Research Group, Regenerative Medicine and Stem Cells, Ljimani, Alexandra, Caroli, Anna, Laustsen, Christoffer, Francis, Susan, Mendichovszky, Iosif Alexandru, Bane, Octavia, Nery, Fabio, Sharma, Kanishka, Pohlmann, Andreas, Dekkers, Ilona A, Vallee, Jean-Paul, Derlin, Katja, Notohamiprodjo, Mike, Lim, Ruth P, Palmucci, Stefano, Serai, Suraj D, Periquito, Joao, Wang, Zhen Jane, Froeling, Martijn, Thoeny, Harriet C, Prasad, Pottumarthi, Schneider, Moritz, Niendorf, Thoralf, Pullens, Pim, Sourbron, Steven, and Sigmund, Eric E

Published
2020

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