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16. Chambers, Anthony

Author

Thoburn, John W., Breunlin, Douglas C., Section editor, Lebow, Jay L., editor, Chambers, Anthony L., editor, and Breunlin, Douglas C., editor

Published
2019
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18. Book Notes

Author

Rebelo, Ivona, Bonetti, Shane, Meeks, J. G. T., Johnes, Geraint, Steedman, Ian, Kennedy, Peter, Dow, Sheila C., Salisu, Mohammed Adaya, Massilia, Marzia Raybaudi, Redmond, John, Pilbeam, Keith, Bonetti, Shane, Ozawa, Terutoma, Berkouwer, J., Ghosh, Dipak, Morgan, Claire, Toivanen, Otto, Holmes, Mark J., Cohen, Ivan, Murinde, Victor, Myles, Gareth, Borooah, Vani, Barrientos, Armando, Siebert, W. S., Sicca, Renato, Liu, Minquan, Beesley, Michael, Trotter, Stephen, Tomlinson, B. R., Hall, Alastair, Stevens, Paul, Thoburn, John, Poyago-Theotoky, Joanna, Wright, Gavin, Alence, Rod, Morrissey, Oliver, Roberts, Jennifer, Teal, Francis, Harding, Rebecca, Kokko, Ari, Spash, Clive L., Markandya, A., and Collins, Alan

Published
1998

27. Collaborative Treatment for the Psychosomatic Couple

Author

Thoburn, John, Hoffman-Robinson, Gwynith, and Shelly, Lauren J.

Abstract

This article reflects on the conceptualization and treatment strategies associated with a systems perspective of the somatic couple. It is suggested that resistance to change, nurturance of the somatic patient by his or her partner, and rigid role taking serve to promote relationship stability and individual pseudopower at the cost of patient health. The authors suggest that psychotherapists can aid primary care physicians in more effective treatment for somatizing patients by educating physicians about the role of the couple relationship in the maintenance of somatic disorder, how the somatizing patient can triangulate health care into an unstable dyadic relationship, and the usefulness of a multidisciplinary, contextual approach to the treatment of somatization. A case example is offered to demonstrate these concepts.

Published
2009
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28. Controlling the Complexity and Interconversion Mechanisms in Self-Assembled [Fe2L3]4+ Helicates and [Fe4L6]8+ Cages

Author

Siddique, Rashid G., Arachchige, Kasun S.A., AL-Fayaad, Hydar A., Thoburn, John D., McMurtrie, John C., Clegg, Jack K., Siddique, Rashid G., Arachchige, Kasun S.A., AL-Fayaad, Hydar A., Thoburn, John D., McMurtrie, John C., and Clegg, Jack K.

Abstract

Self-assembled coordination cages and metal–organic frameworks have relied extensively on symmetric ligands in their formation. Here we have prepared a relatively simple system employing an unsymmetric ligand that results in two distinct self-assembled structures, a [Fe2L3]4+ helicate and a [Fe4L6]8+ cage composed of 10 interconverting diastereomers and their enantiomers. We show that the steric profile of the ligand controls the complexity, thermodynamics and kinetics of interconversion of the system.

Published
2022

37. Glucose Binding Drives Reconfiguration of a Dynamic Library of Urea-Containing Metal-Organic Assemblies

Author

Yang, Dong, Von Krbek, Larissa KS, Yu, Le, Ronson, Tanya K, Thoburn, John D, Carpenter, John P, Greenfield, Jake L, Howe, Duncan J, Wu, Biao, Nitschke, Jonathan R, Yang, Dong [0000-0002-1971-7349], von Krbek, Larissa KS [0000-0002-4278-5235], Yu, Le [0000-0002-0360-290X], Ronson, Tanya K [0000-0002-6917-3685], Carpenter, John P [0000-0002-4341-2887], Greenfield, Jake L [0000-0002-7650-5414], Wu, Biao [0000-0002-0724-4150], Nitschke, Jonathan R [0000-0002-4060-5122], and Apollo - University of Cambridge Repository

Subjects
dynamic combinatorial library, metal-organic assemblies, glucose binding, supramolecular chemistry, host-guest systems
Abstract

A bis-urea-functionalized ditopic subcomponent assembled with 2-formylpyridine and FeII , resulting in a dynamic library of metal-organic assemblies: an irregular FeII4 L6 structure and three FeII2 L3 stereoisomers: left- and right-handed helicates and a meso-structure. This library reconfigured in response to the addition of monosaccharide derivatives, which served as guests for specific library members, and the rate of saccharide mutarotation was also enhanced by the library. The (P) enantiomer of the FeII2 L3 helical structure bound β-D-glucose selectively over α-D-glucose. As a consequence, the library collapsed into the (P)-FeII2 L3 helicate following glucose addition. The α-D-glucose was likewise transformed into the β-D-anomer during equilibration and binding. Thus, β-D-glucose and (P)-3 amplified each other in the product mixture, as metal-organic and saccharide libraries geared together into a single equilibrating system.

Published
2021

38. The kinetics and mechanism of interconversion within a system of [Fe2L3]4+ helicates and [Fe4L 6]8+ cages

Author

Siddique, Rashid G., Arachchige, Kasun S.A., Al-Fayaad, Hydar A., Brock, Aidan J., Micallef, Aaron S., Luis, Ena T., Thoburn, John D., McMurtrie, John C., Clegg, Jack K., Siddique, Rashid G., Arachchige, Kasun S.A., Al-Fayaad, Hydar A., Brock, Aidan J., Micallef, Aaron S., Luis, Ena T., Thoburn, John D., McMurtrie, John C., and Clegg, Jack K.

Abstract

Nature builds simple molecules into highly complex assemblies, which are involved in all fundamental processes of life. Some of the most intriguing biological assemblies are those that can be precisely reconfigured to achieve different functions using the same building blocks. Understanding the reconfiguration of synthetic self-assembled systems will allow us to better understand the complexity of proteins and design useful artificial chemical systems. Here we have prepared a relatively simple system in which two distinct self-assembled structures, a [Fe2L3]4+ helicate and a [Fe4L6]8+ cage that are formed from the same precursors, coexist at equilibrium. We have measured the rates of interconversion of these two species and propose a mechanism for the transformation.

Published
2021

42. Guest Binding Drives Host Redistribution in Libraries of CoII 4 L4 Cages

Author

Kieffer, Marion, Bilbeisi, Rana A, Thoburn, John D, Clegg, Jack K, Nitschke, Jonathan R, Kieffer, Marion [0000-0003-0202-7445], Clegg, Jack K [0000-0002-7140-5596], Nitschke, Jonathan R [0000-0002-4060-5122], and Apollo - University of Cambridge Repository

Subjects
self-assembly, supramolecular library, host-guest systems, mass spectrometry, metal-organic Cages
Abstract

Two CoII 4 L4 tetrahedral cages prepared from similar building blocks showed contrasting host-guest properties. One cage did not bind guests, whereas the second encapsulated a series of anions, due to electronic and geometric effects. When the building blocks of both cages were present during self-assembly, a library of five CoII LA x LB 4-x cages was formed in a statistical ratio in the absence of guests. Upon incorporation of anions able to interact preferentially with some library members, the products obtained were redistributed in favor of the best anion binders. To quantify the magnitudes of these templation effects, ESI-MS was used to gauge the effect of each template upon library redistribution.

Published
2020

49. Industrial policy and automotive development: a comparative study of Thailand and Czechia.

Author

Natsuda, Kaoru, Thoburn, John, Blažek, Jiří, and Otsuka, Kozo

Subjects
*INDUSTRIAL policy, *INDUSTRIALIZATION, *GLOBAL production networks, *INTERVENTION (Federal government), *FOREIGN investments, *EXPORT controls
Abstract

This paper investigates the effectiveness of industrial policy, and the role of state capacity to implement it, by making a comparison of automotive development in Thailand and Czechia, the largest vehicle producers in Southeast Asia and Central and Eastern Europe, respectively. The development of the industry in both countries primarily relied on foreign investment, despite Czechia's long earlier history of domestic automotive development. The countries, however, have used very different types of industrial policy. Thailand introduced a series of vertical (sector-specific) industrial policies, pursuing a proactive industrial development strategy with state intervention, continuing even under the restrictions on trade-related policy measures imposed by the WTO since 2000. In contrast, Czechia has employed mostly horizontal (non-sector-specific) industrial policies with less state intervention, influenced by the restrictions of the European Union. Although both countries achieved considerable output and export growth, Thailand has a deeper and more locally owned supply chain. Thailand's imaginative use of de facto local content requirements in connection with its product champion policy is instructive. [ABSTRACT FROM AUTHOR]

Published
2022
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