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340 results on '"Thistlethwaite, J. R."'

12. Leberchirurgie II

Author

Herfarth, Ch., Hohenberger, P., Schwemmle, K., Hottenrott, C., Lorenz, M., Gubernatis, G., Vogt, P., Raab, R., Kremer, B., Ringe, B., Mauz, S., Barg-Hock, H., Kotzerke, J., Pichlmayr, R., Broelsch, E., Vogelbach, P., Emond, J. C., Thistlethwaite, J. R., Woodle, S. A., Baker, A. L., Whitington, P. F., Neuhaus, P., Steffen, R., Hamelmann, H., and Ungeheuer, E., editor

Published
1989
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18. Liver transplantation in children from living related donors. Surgical techniques and results

Author

Broelsch, C E, Whitington, P F, Emond, J C, Heffron, T G, Thistlethwaite, J R, Stevens, L, Piper, J, Whitington, S H, and Lichtor, J L

Subjects
Research Article
Abstract

Pediatric liver transplantation with reduced size donor organs (RLT) has evolved into a standard clinical procedure increasing the choices of recipients for their treatment. Nevertheless organ availability remains a major problem. The authors therefore have proposed to study the use of hepatic segments from living related donors (LRT) in a group of 20 children less than 2 years of age or weighing less than 15 kg, in whom standard indications for transplantation existed. Volunteer related donors were selected after medical and psychiatric evaluations, and the suitability of the donor's liver was established by functional and radiologic criteria. A two-stage informed consent process assured appropriate "volunteerism." Nineteen infants received LRT as first grafts and one as a second graft. Seventeen of the recipients are alive 3 to 18 months after LRT. Fifteen of 20 patients are currently at home with the original graft and normal liver function (bilirubin less than 1.5 mg/dl) after a median hospital stay of 27 days (range, 14-93 days). Four patients underwent retransplantation, in all cases due to arterial thrombosis. The overall graft survival for 20 primary LRTs is 75%, with follow-up between 3 and 18 months. A number of technical problems occurred during our initial trial, the most aggravating being vascular thrombosis. Refined approaches to vascular reconstruction should reduce the incidence of thrombosis and improve the rate of survival in future cases. The donor group for the initial 20 LRT procedures comprised 12 mothers, 7 fathers, and 1 grandmother. In addition one father and one uncle, who was an identical twin of the recipient's father, who did not qualify for anatomic reasons, were used in repeat LRT. All donors survived and are now in normal health between 3 and 18 months after LRT, having returned to all activities enjoyed before donation. The median hospital stay was 6 days (range, 5-14). Complications were minimal, and all were limited to the first three procedures, in which a full left hepatectomy was performed. After alteration of the procedure into a left lateral segmentectomy, no complications were encountered. The left lateral segmentectomy presents minimal surgical trauma to the liver and should remain the primary approach for obtaining a liver graft from a living donor. For children, transplantation of a left lateral segment from a live donor provides a new way of providing a transplant of appropriate size and with good function. The success of this program has led to the acceptance of LRT for general clinical application in the authors' institution.

Published
1991

20. INDUCTION, MAINTENANCE, AND REVERSAL OF STREPTOZOTOCIN-INDUCED INSULIN-DEPENDENT DIABETES MELLITUS IN THE JUVENILE CYNOMOLGUS MONKEY (Macaca fascilularis)1

Author

Theriault, Betty R., primary, Thistlethwaite, J. R., additional, Levisetti, Matteo G., additional, Wardrip, Craig L., additional, Szot, Gregory, additional, Bruce, David S., additional, Rilo, Horatio, additional, Li, Xiantang, additional, Gray, Gary S., additional, Bluestone, Jeffrey A., additional, and Padrid, Philip A., additional

Published
1999
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23. EARLY CORTICOSTEROID WITHDRAWAL WITH TACROLIMUS AND MYCOPHENOLATE MOFETIL (MMF) IMMUNO-SUPPRESSION IN RENAL TRANSPLANTATION: EIGHTEEN-MONTH FOLLOW-UP

Author

BUELL, J F, primary, GREWAL, H P, additional, KRISTO, B, additional, KOPELAN, A, additional, KULKARNI, S, additional, YOSHIDA, A, additional, KIM, E, additional, SIEGEL, C, additional, CRONIN, D C, additional, BRUCE, D S, additional, NEWELL, K A, additional, MILLIS, J M, additional, THISTLETHWAITE, J R, additional, and WOODLE, E S, additional

Published
1999
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28. COMBINED LIVER AND KIDNEY TRANSPLANTATION (LKT) IN CHILDREN

Author

Grewal, H P, primary, Brady, L, additional, Cronin, D, additional, Loss, G E, additional, Siegel, C T, additional, Oswald, K, additional, Fisher, J S, additional, Bruce, D S, additional, Woodle, E S, additional, Millis, J M, additional, Thistlethwaite, J R, additional, and Newell, K A, additional

Published
1998
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34. AN ANALYSIS OF HEPATIC RETRANSPLANTATION IN CHILDREN

Author

Newell, K. A., primary, Millis, J. M., additional, Bruce, D. S., additional, Woodle, E. S., additional, Cronin, D. C., additional, Loss, G., additional, Grewal, H., additional, Alonso, E. M., additional, Dillon, J. J., additional, Whitington, P. F., additional, and Thistlethwaite, J. R., additional

Published
1998
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49. Muscle Strength and Pressor Response.

Author

Gonzales, J. U., Thompson, B. C., Thistlethwaite, J. R., Harper, A. J., and Scheuermann, B. W.

Subjects
MEN'S health, MUSCLE strength, ENDURANCE athletes, ENDURANCE sports, PHYSICAL fitness for men, PHYSICAL education, HEMODYNAMICS
Abstract

The purpose of this study was to determine if muscle strength influences the hyperemic response to dynamic exercise. Men with low (n=8) and high (n=9) maximal forearm strength performed dynamic handgrip exercise as the same absolute workload increased in a ramp function (0.5kg·min-1). Forearm blood flow (FBF) was measured instantaneously by ultrasound Doppler and blood pressure was measured by auscultation. The pressor response to exercise was greater (P<0.05) for low strength men at workloads >1.5 kg allowing volumetric FBF (ml·min-1) and vascular conductance to increase in proportion to absolute workload similar to high strength men. When FBF was expressed relative to forearm volume (ml·min-1·100ml-1) the hyperemic response to exercise (slope of relative FBF vs. workload) was greater in low strength men (3.2±1.5 vs. 1.7±0.4ml·min-1·100ml-1·kg-1, P<0.05) as was relative FBF at workloads >1.5kg. However, when relative FBF was compared across relative work intensity, no difference was found between low and high strength groups. Together, these findings suggest men with low strength require a greater pressor response to match blood flow to exercise intensity as compared to high strength men. [ABSTRACT FROM AUTHOR]

Published
2009
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