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11 results on '"Thirstrup, Derek J."'

1. Automated human induced pluripotent stem cell culture and sample preparation for 3D live-cell microscopy

Author

Gregor, Benjamin W., Coston, Mackenzie E., Adams, Ellen M., Arakaki, Joy, Borensztejn, Antoine, Do, Thao P., Fuqua, Margaret A., Haupt, Amanda, Hendershott, Melissa C., Leung, Winnie, Mueller, Irina A., Nath, Aditya, Nelson, Angelique M., Rafelski, Susanne M., Sanchez, Emmanuel E., Swain-Bowden, Madison J., Tang, W. Joyce, Thirstrup, Derek J., Wiegraebe, Winfried, Whitney, Brian P., Yan, Calysta, Gunawardane, Ruwanthi N., and Gaudreault, Nathalie

Published
2024
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2. Integrated intracellular organization and its variations in human iPS cells

Author

Viana, Matheus P., Chen, Jianxu, Knijnenburg, Theo A., Vasan, Ritvik, Yan, Calysta, Arakaki, Joy E., Bailey, Matte, Berry, Ben, Borensztejn, Antoine, Brown, Eva M., Carlson, Sara, Cass, Julie A., Chaudhuri, Basudev, Cordes Metzler, Kimberly R., Coston, Mackenzie E., Crabtree, Zach J., Davidson, Steve, DeLizo, Colette M., Dhaka, Shailja, Dinh, Stephanie Q., Do, Thao P., Domingus, Justin, Donovan-Maiye, Rory M., Ferrante, Alexandra J., Foster, Tyler J., Frick, Christopher L., Fujioka, Griffin, Fuqua, Margaret A., Gehring, Jamie L., Gerbin, Kaytlyn A., Grancharova, Tanya, Gregor, Benjamin W., Harrylock, Lisa J., Haupt, Amanda, Hendershott, Melissa C., Hookway, Caroline, Horwitz, Alan R., Hughes, H. Christopher, Isaac, Eric J., Johnson, Gregory R., Kim, Brian, Leonard, Andrew N., Leung, Winnie W., Lucas, Jordan J., Ludmann, Susan A., Lyons, Blair M., Malik, Haseeb, McGregor, Ryan, Medrash, Gabe E., Meharry, Sean L., Mitcham, Kevin, Mueller, Irina A., Murphy-Stevens, Timothy L., Nath, Aditya, Nelson, Angelique M., Oluoch, Sandra A., Paleologu, Luana, Popiel, T. Alexander, Riel-Mehan, Megan M., Roberts, Brock, Schaefbauer, Lisa M., Schwarzl, Magdalena, Sherman, Jamie, Slaton, Sylvain, Sluzewski, M. Filip, Smith, Jacqueline E., Sul, Youngmee, Swain-Bowden, Madison J., Tang, W. Joyce, Thirstrup, Derek J., Toloudis, Daniel M., Tucker, Andrew P., Valencia, Veronica, Wiegraebe, Winfried, Wijeratna, Thushara, Yang, Ruian, Zaunbrecher, Rebecca J., Labitigan, Ramon Lorenzo D., Sanborn, Adrian L., Johnson, Graham T., Gunawardane, Ruwanthi N., Gaudreault, Nathalie, Theriot, Julie A., and Rafelski, Susanne M.

Published
2023
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3. Automated human induced pluripotent stem cell culture and sample preparation for 3D live-cell microscopy

Author

Gregor, Benjamin W., primary, Coston, Mackenzie E., additional, Adams, Ellen M., additional, Arakaki, Joy, additional, Borensztejn, Antoine, additional, Do, Thao P., additional, Fuqua, Margaret A., additional, Haupt, Amanda, additional, Hendershott, Melissa C., additional, Leung, Winnie, additional, Mueller, Irina A., additional, Nath, Aditya, additional, Nelson, Angelique M., additional, Rafelski, Susanne M., additional, Sanchez, Emmanuel E., additional, Swain-Bowden, Madison J., additional, Tang, W. Joyce, additional, Thirstrup, Derek J., additional, Wiegraebe, Winfried, additional, Whitney, Brian P., additional, Yan, Calysta, additional, Gunawardane, Ruwanthi N., additional, and Gaudreault, Nathalie, additional

Published
2023
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5. Automated hiPSC culture and sample preparation for 3D live cell microscopy

Author

Coston, Mackenzie E., primary, Gregor, Benjamin W., additional, Arakaki, Joy, additional, Borensztejn, Antoine, additional, Do, Thao P., additional, Fuqua, Margaret A., additional, Haupt, Amanda, additional, Hendershott, Melissa C., additional, Leung, Winnie, additional, Mueller, Irina A., additional, Nelson, Angelique M., additional, Rafelski, Susanne M., additional, Swain-Bowden, Madison J., additional, Tang, W. Joyce, additional, Thirstrup, Derek J., additional, Wiegraebe, Winfried, additional, Yan, Calysta, additional, Gunawardane, Ruwanthi N, additional, and Gaudreault, Nathalie, additional

Published
2020
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6. Multidrug Analyses in Patients Distinguish Efficacious Cancer Agents Based on Both Tumor Cell Killing and Immunomodulation

Author

Frazier, Jason P., primary, Bertout, Jessica A., additional, Kerwin, William S., additional, Moreno-Gonzalez, Alicia, additional, Casalini, Joey R., additional, Grenley, Marc O., additional, Beirne, Emily, additional, Watts, Kori L., additional, Keener, Andy, additional, Thirstrup, Derek J., additional, Tretyak, Ilona, additional, Ditzler, Sally H., additional, Tripp, Chelsea D., additional, Choy, Kevin, additional, Gillings, Sarah, additional, Breit, Megan N., additional, Meleo, Karri A., additional, Rizzo, Vanessa, additional, Herrera, Chamisa L., additional, Perry, James A., additional, Amaravadi, Ravi K., additional, Olson, James M., additional, and Klinghoffer, Richard A., additional

Published
2017
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7. A Platform for Rapid, Quantitative Assessment of Multiple Drug Combinations Simultaneously in Solid Tumors In Vivo

Author

Dey, Joyoti, primary, Kerwin, William S., additional, Grenley, Marc O., additional, Casalini, Joseph R., additional, Tretyak, Ilona, additional, Ditzler, Sally H., additional, Thirstrup, Derek J., additional, Frazier, Jason P., additional, Pierce, Daniel W., additional, Carleton, Michael, additional, and Klinghoffer, Richard A., additional

Published
2016
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9. A technology platform to assess multiple cancer agents simultaneously within a patient’s tumor

Author

Klinghoffer, Richard A., primary, Bahrami, S. Bahram, additional, Hatton, Beryl A., additional, Frazier, Jason P., additional, Moreno-Gonzalez, Alicia, additional, Strand, Andrew D., additional, Kerwin, William S., additional, Casalini, Joseph R., additional, Thirstrup, Derek J., additional, You, Sheng, additional, Morris, Shelli M., additional, Watts, Korashon L., additional, Veiseh, Mandana, additional, Grenley, Marc O., additional, Tretyak, Ilona, additional, Dey, Joyoti, additional, Carleton, Michael, additional, Beirne, Emily, additional, Pedro, Kyle D., additional, Ditzler, Sally H., additional, Girard, Emily J., additional, Deckwerth, Thomas L., additional, Bertout, Jessica A., additional, Meleo, Karri A., additional, Filvaroff, Ellen H., additional, Chopra, Rajesh, additional, Press, Oliver W., additional, and Olson, James M., additional

Published
2015
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10. Minimally invasive in tumor multidrug comparative analysis with contrast-enhanced MRI in mice.

Author

Kerwin, William S., Tretyak, Ilona, Grenley, Marc O., You, Sheng, Hatton, Beryl A., Moreno‐Gonzalez, Alicia, Thirstrup, Derek J., and Klinghoffer, Richard A.

Abstract

Purpose To facilitate decision making in the oncology clinic, technologies have recently been developed to independently inject and assess multiple anticancer agents directly in a patient's tumor. To increase the flexibility of this approach beyond histological readouts of response, contrast-enhanced MRI was evaluated for the detection of cell death in living tumors after injection. Methods A six-needle arrayed microinjection device designed to provide head-to-head comparisons of chemotherapy responses in living tumors was used. Xenografted non-Hodgkin lymphoma tumors in athymic Nude-Foxn1nu mice were injected either with different doses of vincristine or with one needle each of vincristine, doxorubicin, bendamustine, prednisolone, mafosfamide, and a vehicle control. To assess drug responses, measurements of enhancement by T1-weighted contrast-enhanced MRI were made for individual sites at 24, 48, and 72 h after injection. For comparison, histological evaluations of cell death were obtained after tumor resection. Results Measurements of MRI enhancement at injection sites showed a significant ( P < 0.001) positive regression slope as a function of vincristine dose. Average MRI measurements were closely correlated with cell death by hematoxylin and eosin staining (R = 0.81; P = 0.001). Conclusion Contrast-enhanced MRI has the potential to replace or augment histological analyses of tumor responses to microinjected doses of chemotherapy agents with potential application in selecting optimal chemotherapy regimens. Magn Reson Med 76:946-952, 2016. © 2015 Wiley Periodicals, Inc. [ABSTRACT FROM AUTHOR]

Published
2016
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11. Colony context and size-dependent compensation mechanisms give rise to variations in nuclear growth trajectories.

Author

Dixon JC, Frick CL, Leveille CL, Garrison P, Lee PA, Mogre SS, Morris B, Nivedita N, Vasan R, Chen J, Fraser CL, Gamlin CR, Harris LK, Hendershott MC, Johnson GT, Klein KN, Oluoch SA, Thirstrup DJ, Sluzewski MF, Wilhelm L, Yang R, Toloudis DM, Viana MP, Theriot JA, and Rafelski SM

Abstract

To investigate the fundamental question of how cellular variations arise across spatiotemporal scales in a population of identical healthy cells, we focused on nuclear growth in hiPS cell colonies as a model system. We generated a 3D timelapse dataset of thousands of nuclei over multiple days, and developed open-source tools for image and data analysis and an interactive timelapse viewer for exploring quantitative features of nuclear size and shape. We performed a data-driven analysis of nuclear growth variations across timescales. We found that individual nuclear volume growth trajectories arise from short timescale variations attributable to their spatiotemporal context within the colony. We identified a strikingly time-invariant volume compensation relationship between nuclear growth duration and starting volume across the population. Notably, we discovered that inheritance plays a crucial role in determining these two key nuclear growth features while other growth features are determined by their spatiotemporal context and are not inherited., Competing Interests: Declaration of interests The authors declare no competing interests.

Published
2024
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