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366 results on '"Thiounn, N."'

3. Multicentric evaluation of the oncological outcomes and management of recurrence after brachytherapy for prostate cancer

Author

Benchimol, Y., primary, Taussky, D., additional, Thiounn, N., additional, Bouche, G., additional, Ramiandrisoa, F., additional, Delouya, G., additional, Taha, F., additional, Meynard, C., additional, Giraud, P., additional, Bibault, J-E., additional, Kreps, S., additional, Timsit, M-O., additional, Méjean, A., additional, Larré, S., additional, and Dariane, C., additional

Published
2024
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4. Impact of the hypoxic microenvironment on spermatogonial stem cells in culture

Author

Gille, A. S., primary, Givelet, M., additional, Pehlic, D., additional, Lapoujade, C., additional, Lassalle, B., additional, Barroca, V., additional, Bemelmans, A. P., additional, Borderie, D., additional, Moison, D., additional, Livera, G., additional, Gauthier, L. R., additional, Boussin, F. D., additional, Thiounn, N., additional, Allemand, I., additional, Peyssonnaux, C., additional, Wolf, J. P., additional, Barraud-Lange, V., additional, Riou, L., additional, and Fouchet, P., additional

Published
2024
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9. P-554 Impact of genotype and phenotype on ICSI outcomes of cystic fibrosis (CF) men patients: a cohort study about 107 ICSI from 1999 to 2019

Author

Chargui, A, primary, Adjiman, L, additional, Hubert, D, additional, Bourdon, M, additional, Ferreux, L, additional, Maignien, C, additional, Gille, A.S, additional, Rivet Danon, D, additional, Pocate, K, additional, Thiounn, N, additional, Santulli, P, additional, Bienvenu, T, additional, and Patrat, C, additional

Published
2022
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38. Comparaison de la chirurgie conservatrice vs ablation par radiofréquence pour le traitement du carcinome à cellules rénales après 75ans

Author

Cholley, I., primary, Correas, J., additional, Sanchez, S., additional, Ariane, M., additional, Fontaine, E., additional, Thiounn, N., additional, Hurel, S., additional, Le Guilchet, T., additional, Champy, C., additional, Audenet, F., additional, Pietak, M., additional, Méjean, A., additional, and Timsit, M., additional

Published
2015
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40. [Brachytherapy in the curative treatment of localized prostatic cancer]

Author

Flam T, Chauveinc L, Vincent Servois, Jc, Rosenwald, Jm, Cosset, Thiounn N, and Debré B

Subjects
Male, Prostatectomy, Treatment Outcome, Patient Selection, Brachytherapy, Humans, Prostatic Neoplasms, Radiotherapy Dosage, Combined Modality Therapy
Abstract

The treatment of clinically localized prostate cancer is based on total prostatectomy, radiotherapy or surveillance. The adverse effects of these treatments have led to an increasing interest in alternatives with decreased morbidity. Brachytherapy consists of placing radioactive sources in the prostatic tissue. High doses can therefore be delivered to the cancer while avoiding excessive irradiation of the bladder and rectum. Brachytherapy generally uses permanent implants (Iodine 125 or Palladium 103). The so-called Seattle technique requires planning before implantation, while, in the "ProCeed" technique, the position of the grains is determined at the time of treatment, with the help of a computer programme which determines the dosimetry. Brachytherapy is a reliable and reproducible technique with minimal morbidity, providing 10-year results comparable to those of total prostatectomy.

Published
2000

41. [Intracytoplasmic sperm injection (ICSI) in the management of azoospermia]

Author

Izard V, Thiounn N, Poirot C, Bouker A, sylvie epelboin, Jr, Zorn, Jouannet P, Debré B, Jardin A, and Jp, Wolf

Subjects
Adult, Male, Microinjections, Pregnancy, Pregnancy Outcome, Humans, Female, Fertilization in Vitro, Oligospermia, Middle Aged, Embryo Transfer, Retrospective Studies
Abstract

The objective of this study was to analyse all attempts of ICSI performed in our centre between 1995 and 1997 with surgically harvested sperm for the treatment of secretory and excretory azoospermia.71 infertile couples, in which the man suffered from secretory (n = 8) or excretory azoospermia (n = 63), were managed with 94 attempts of ICSI.ICSI was able to be performed 85 times with 82 embryo transfers resulting in 29 clinical pregnancies. The clinical pregnancy rate per ICSI attempt was comparable with sperm obtained on the day of ICSI or previously harvested and frozen (30.5% and 31.4% respectively). The clinical pregnancy rate per ICSI attempt was 33.3% for testicular sperm (n = 18), and 30.3% for epididymal sperm (n = 76). Twenty-seven clinical pregnancies (32.1%) were obtained for men with excretory azoospermia (47.2% for vas deferens agenesis and 20.8% for acquired urinary tract obstruction, p = 0.01), and 2 (20%) for men with secretory azoospermia.ICSI can achieve pregnancy in infertile couples in whom no other solution can be considered. Cryopreservation allows surgical harvesting to be dissociated from ICSI without decreasing the pregnancy rate, justifying freezing of sperm during any surgical procedure on the seminal tract. The better results obtained in congenital excretory azoospermia compared to acquired obstructions, usually post-infectious, suggest a harmful effect of infection on the quality of sperm.

Published
1999

42. [Intra-cytoplasmic sperm injection with testicular sperm: what strategy?]

Author

Thiounn N, Yz, Ji, Izard V, sylvie epelboin, Jr, Zorn, Debré B, Jardin A, Jouannet P, and Jp, Wolf

Subjects
Adult, Male, Microinjections, Pregnancy Outcome, Fertilization in Vitro, Oligospermia, Middle Aged, Erectile Dysfunction, Pregnancy, Testis, Humans, Female, Infertility, Male, Insemination, Artificial, Zona Pellucida, Retrospective Studies
Abstract

The pregnancy rate after ICSI with surgically retrieved spermatozoa varies according to the etiology and to the level of sperm retrieval in the genital tract. The use of testicular sperm in all cases is discussed.

Published
1997

44. [Resistance to chemotherapy in cancers of the kidney and therapeutic perspectives]

Author

Stephane OUDARD, Thiounn N, Batel Copel L, Chauvenet L, Pujade Lauraine E, and Bernadou A

Subjects
Piperidines, Drug Resistance, Neoplasm, Triazines, Humans, Antineoplastic Agents, Cyclosporins, ATP Binding Cassette Transporter, Subfamily B, Member 1, Kidney Neoplasms
Abstract

Usual treatments combining surgery, radiation therapy, chemotherapy and hormonotherapy are poorly effective. The immunotherapy gave and objective response rate of 25% but is associated with many side effects. Multidrug resistance (MDR) can be explained, in part, by an mdr1 gene overexpression in renal carcinoma. The MDR is related to expression of a 170 Kda membrane glycoprotein, the so-called P glycoprotein (Pgp). This protein is able to extrude from cytoplasm drugs with various structures and mechanisms. Reversal compounds capable of inhibiting Pgp, given with antineoplastic drugs, could be able to increase their intracellular concentrations. Nevertheless, renal cell carcinomas are characterized by their multifactorial resistance and a better knowledge in this field will allow to design new circumvention resistance to chemotherapy.

Published
1995

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