Rouamba,Toussaint, Barry,Houreratou, Ouédraogo,Espérance, Tahita,Marc Christian, Yaméogo,Nobila Valentin, Poda,Armel, Diendéré,Eric Arnaud, Ouedraogo,Abdoul-Salam, Valea,Innocent, Koné,Amariane M, Thiombiano,Cherileila, Traoré,Isidore, Tarnagda,Zekiba, Sawadogo,Serge Aimé, Gansané,Zakaria, Kambiré,Yibar, Sanou,Idrissa, Barro-Traoré,Fatou, Drabo,Maxime K, Tinto,Halidou, Rouamba,Toussaint, Barry,Houreratou, Ouédraogo,Espérance, Tahita,Marc Christian, Yaméogo,Nobila Valentin, Poda,Armel, Diendéré,Eric Arnaud, Ouedraogo,Abdoul-Salam, Valea,Innocent, Koné,Amariane M, Thiombiano,Cherileila, Traoré,Isidore, Tarnagda,Zekiba, Sawadogo,Serge Aimé, Gansané,Zakaria, Kambiré,Yibar, Sanou,Idrissa, Barro-Traoré,Fatou, Drabo,Maxime K, and Tinto,Halidou
Toussaint Rouamba,1,* Houreratou Barry,2,* Esperance Ouédraogo,1 Marc Christian Tahita,1 Nobila Valentin Yaméogo,3 Armel Poda,4 Arnaud Eric Diendéré,5 Abdoul-Salam Ouedraogo,4 Innocent Valea,1 Amariane M Koné,2 Cherileila Thiombiano,2 Isidore Traoré,2 Zekiba Tarnagda,1 Serge A Sawadogo,6 Zakaria Gansané,7 Yibar Kambiré,8 Idrissa Sanou,8 Fatou Barro-Traoré,8 Maxime K Drabo,1 Halidou Tinto1 On behalf of the CHLORAZ Study Group1Institut de Recherche en Sciences de la Santé (CNRST-IRSS), Nanoro, Burkina Faso; 2Institut National de Santé Publique, Centre Muraz, Bobo-Dioulasso, Burkina Faso; 3Centre Hospitalier Universitaire Yalgado Ouédraogo, Ouagadougou, Burkina Faso; 4Centre Hospitalier Universitaire Sourou Sanon, Bobo-Dioulasso, Burkina Faso; 5Centre Hospitalier Universitaire de Bogodogo, Ouagadougou, Burkina Faso; 6Centre PrïmO Nelson Mandela (Promotion de la Recherche et de lâInnovation en Immunologie Médicale de Ouagadougou), Ouagadougou, Burkina Faso; 7Clinical Monitoring in Africa-Clinical Research Organization, Ouagadougou, Burkina Faso; 8Centre Hospitalier Universitaire de Tengandogo, Ouagadougou, Burkina Faso*These authors contributed equally to this workCorrespondence: Toussaint RouambaInstitut de Recherche en Sciences de la Santé (CNRST-IRSS), 528, Avenue Kumda-Yoore, BP 218 Ouagadougou CMS 11, Ouagadougou, Nanoro, Burkina FasoTel +226 666 532 04Email rouambatoussaint@gmail.comIntroduction: Though chloroquine derivatives are used in the treatment of coronavirus disease 2019 (COVID-19) in many countries worldwide, doubts remain about the safety and efficacy of these drugs, especially in African communities where published data are scarce.Methods: We conducted an observational prospective cohort study from April 24 to September 03, 2020, in Burkina Faso to assess (as primary outcome) the clinical, biological, and cardiac (electrocardiographic) safety of chloroquine or hydroxychloroquine plus azithromycin administered to