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3. Relationship of device measured physical activity type and posture with cardiometabolic health markers: pooled dose–response associations from the Prospective Physical Activity, Sitting and Sleep Consortium

Author

Ahmadi, Matthew N., Blodgett, Joanna M., Atkin, Andrew J., Chan, Hsiu-Wen, del Pozo Cruz, Borja, Suorsa, Kristin, Bakker, Esmee A., Pulsford, Richard M., Mielke, Gregore I., Johansson, Peter J., Hettiarachchi, Pasan, Thijssen, Dick H. J., Stenholm, Sari, Mishra, Gita D., Teixeira-Pinot, Armando, Rangul, Vegar, Sherar, Lauren B., Ekelund, Ulf, Hughes, Alun D., Lee, I.-Min, Holtermann, Andreas, Koster, Annemarie, Hamer, Mark, and Stamatakis, Emmanuel

Published
2024
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18. Temporal dynamics of sitting behavior at work

Author

Broeke, Pam ten, Olthof, Merlijn, Beckers, Debby G. J., Hopkins, Nicola D., Graves, Lee E. F., Carter, Sophie E., Cochrane, Madeleine, Gavin, David, Morris, Abigail S., Lichtwarck-Aschoff, Anna, Geurts, Sabine A. E., Thijssen, Dick H. J., and Bijleveld, Erik

Published
2020

22. Preliminary Effects and Acceptability of a Co-Produced Physical Activity Referral Intervention

Author

Buckley, Benjamin J. R., Thijssen, Dick H. J., Murphy, Rebecca C., Graves, Lee E. F., Whyte, Greg, Gillison, Fiona, Crone, Diane, Wilson, Philip M., Hindley, Daniel, and Watson, Paula M.

Abstract

Objectives: To explore the preliminary effects and acceptability of a co-produced physical activity referral intervention. Study Design: Longitudinal design with data collected at baseline and post a 12-week physical activity referral intervention. Setting: Community leisure centre. Methods: In all, 32 adults with controlled lifestyle-related health conditions took part in a physical activity referral intervention (co-produced by a multidisciplinary stakeholder group) comprising 12 weeks subsidised fitness centre access plus four behaviour change consultations. A complete case analysis (t-tests and magnitude-based inferences) was conducted to assess baseline-to-12-week change in physical activity, cardiometabolic, and psychological measures. Semi-structured interviews were conducted (n = 12) to explore experiences of the intervention. Results: Mean improvements were observed in cardiorespiratory fitness (3.6 mL kg-1 min-1 [95% confidence interval: 1.9-5.4], p < 0.001) and moderate-to-vigorous physical activity (12.6 minutes per day [95% confidence interval: 4.3-29.6], p = 0.013). Participants were positive about the support received from exercise referral practitioners, but experienced some challenges in a busy and under staffed gym environment. Conclusions: A co-produced physical activity referral intervention elicited short-term improvements in physical activity and cardiometabolic health. Further refinements may be required, via ongoing feedback between stakeholders, researchers and service users, to achieve the intended holistic physical activity focus of the intervention, prior to a definitive trial.

Published
2019
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26. Cardiac Rehabilitation versus Percutaneous Coronary Intervention for Stable Angina Pectoris: A Retrospective Study of Effects on Major Adverse Cardiovascular Events and Associated Healthcare Costs

Author

de Koning, Iris A, primary, Heutinck, Joyce M, additional, Vromen, Tom, additional, Bakker, Esmée A, additional, Maessen, Martijn F H, additional, Smolders, Jurgen, additional, Eijsvogels, Thijs M H, additional, Grutters, Janneke P C, additional, van Geuns, Robert-Jan M, additional, Kemps, Hareld M C, additional, and Thijssen, Dick H J, additional

Published
2024
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40. Dose-response association between moderate to vigorous physical activity and incident morbidity and mortality for individuals with a different cardiovascular health status: A cohort study among 142,493 adults from the Netherlands

Author

Bakker, Esmée A., Lee, Duck-chul, Hopman, Maria T. E., Oymans, Eline J., Watson, Paula M., Thompson, Paul D., Thijssen, Dick H. J., and Eijsvogels, Thijs. M. H.

Subjects
Exercise -- Statistics -- Health aspects, Cardiovascular diseases -- Patient outcomes -- Risk factors -- Statistics, Biological sciences
Abstract

Background Moderate to vigorous physical activity (MVPA) is strongly associated with risk reductions of noncommunicable diseases and mortality. Cardiovascular health status may influence the benefits of MVPA. We compare the association between MVPA and incident major adverse cardiovascular events (MACE) and mortality between healthy individuals, individuals with elevated levels of cardiovascular risk factors (CVRF), and cardiovascular disease (CVD). Methods and findings A cohort study was performed in the 3 northern provinces of the Netherlands, in which data were collected between 2006 and 2018, with a median follow-up of 6.8 years (Q.sub.25 5.7; Q.sub.75 7.9). A total of 142,493 participants of the Lifelines Cohort Study were stratified at baseline as (1) healthy; (2) CVRF; or (3) CVD. Individuals were categorized into 'inactive' and 4 quartiles of least (Q1) to most (Q4) active based on self-reported MVPA volumes. Primary outcome was a composite of incident MACE and all-cause mortality during follow-up. Cox regression was used to estimate hazard ratios (HRs), 95% confidence intervals (CIs) and P values. The main analyses were stratified on baseline health status and adjusted for age, sex, income, education, alcohol consumption, smoking, protein, fat and carbohydrate intake, kidney function, arrhythmias, hypothyroid, lung disease, osteoarthritis, and rheumatoid arthritis. The event rates were 2.2% in healthy individuals (n = 2,485 of n = 112,018), 7.9% in those with CVRF (n = 2,214 of n = 27,982) and 40.9% in those with CVD (n = 1,019 of n = 2,493). No linear association between MVPA and all-cause mortality or MACE was found for healthy individuals (P = 0.36) and individuals with CVRF (P = 0.86), but a linear association was demonstrated for individuals with CVD (P = 0.04). Adjusted HRs in healthy individuals were 0.81 (95% CI 0.64 to 1.02, P = 0.07), 0.71 (95% CI 0.56 to 0.89, P = 0.004), 0.72 (95% CI 0.57 to 0.91, P = 0.006), and 0.76 (95% CI 0.60 to 0.96, P = 0.02) for MVPA Q1 to Q4, respectively, compared to inactive individuals. In individuals with CVRF, HRs were 0.69 (95% CI 0.57 to 0.82, P < 0.001), 0.66 (95% CI 0.55 to 0.80, P < 0.001), 0.64 (95% CI 0.53 to 0.77, P < 0.001), and 0.69 (95% CI 0.57 to 0.84, P < 0.001) for MVPA Q1 to Q4, respectively, compared to inactive individuals. Finally, HRs for MVPA Q1 to Q4 compared to inactive individuals were 0.80 (95% CI 0.62 to 1.03, P = 0.09), 0.82 (95% CI 0.63 to 1.06, P = 0.13), 0.74 (95% CI 0.57 to 0.95, P = 0.02), and 0.70 (95% CI 0.53 to 0.93, P = 0.01) in CVD patients. Leisure MVPA was associated with the most health benefits, nonleisure MVPA with little health benefits, and occupational MVPA with no health benefits. Study limitations include its observational nature, self-report data about MVPA, and potentially residual confounding despite extensive adjustment for lifestyle risk factors and health-related factors. Conclusions MVPA is beneficial for reducing adverse outcomes, but the shape of the association depends on cardiovascular health status. A curvilinear association was found in healthy and CVRF individuals with a steep risk reduction at low to moderate MVPA volumes and benefits plateauing at high(er) MVPA volumes. CVD patients demonstrated a linear association, suggesting a constant reduction of risk with higher volumes of MVPA. Therefore, individuals with CVDs should be encouraged that 'more is better' regarding MVPA. These findings may help to optimize exercise prescription to gain maximal benefits of a physically active lifestyle., Author(s): Esmée A. Bakker 1,2, Duck-chul Lee 3, Maria T. E. Hopman 1, Eline J. Oymans 1, Paula M. Watson 2, Paul D. Thompson 4, Dick H. J. Thijssen 1,2, [...]

Published
2021
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42. Central and local arterial stiffness in White Europeans compared to age-, sex-, and BMI-matched South Asians

Author

van der Sluijs, Koen M., primary, Thannhauser, Jos, additional, Visser, Iris M., additional, Nabeel, P. M., additional, Raj, Kiran V., additional, Malik, Afrah E. F., additional, Reesink, Koen D., additional, Eijsvogels, Thijs M. H., additional, Bakker, Esmée A., additional, Kaur, Prabhdeep, additional, Joseph, Jayaraj, additional, and Thijssen, Dick H. J., additional

Published
2023
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49. Device-measured physical activity and cardiometabolic health : the Prospective Physical Activity, Sitting, and Sleep (ProPASS) consortium

Author

Blodgett, Joanna M., Ahmadi, Matthew N, Atkin, Andrew J, Chastin, Sebastien, Chan, Hsiu-Wen, Suorsa, Kristin, Bakker, Esmee A., Hettiarachchi, Pasan, Johansson, Peter, Sherar, Lauren B., Rangul, Vegar, Pulsford, Richard M, Mishra, Gita, Eijsvogels, Thijs M H, Stenholm, Sari, Hughes, Alun D, Teixeira-Pinto, Armando M, Ekelund, Ulf, Lee, I Min, Holtermann, Andreas, Koster, Annemarie, Stamatakis, Emmanuel, Hamer, Mark, Gupta, Nidhi, Stehouwer, Coen, Savelberg, Hans, de Galan, Bastiaan, van de Kallen, Carla, Thijssen, Dick H J, Blodgett, Joanna M., Ahmadi, Matthew N, Atkin, Andrew J, Chastin, Sebastien, Chan, Hsiu-Wen, Suorsa, Kristin, Bakker, Esmee A., Hettiarachchi, Pasan, Johansson, Peter, Sherar, Lauren B., Rangul, Vegar, Pulsford, Richard M, Mishra, Gita, Eijsvogels, Thijs M H, Stenholm, Sari, Hughes, Alun D, Teixeira-Pinto, Armando M, Ekelund, Ulf, Lee, I Min, Holtermann, Andreas, Koster, Annemarie, Stamatakis, Emmanuel, Hamer, Mark, Gupta, Nidhi, Stehouwer, Coen, Savelberg, Hans, de Galan, Bastiaan, van de Kallen, Carla, and Thijssen, Dick H J

Abstract

Background and Aims: Physical inactivity, sedentary behaviour (SB), and inadequate sleep are key behavioural risk factors of cardiometabolic diseases. Each behaviour is mainly considered in isolation, despite clear behavioural and biological interdependencies. The aim of this study was to investigate associations of five-part movement compositions with adiposity and cardiometabolic biomarkers. Methods: Cross-sectional data from six studies (n = 15 253 participants; five countries) from the Prospective Physical Activity, Sitting and Sleep consortium were analysed. Device-measured time spent in sleep, SB, standing, light-intensity physical activity (LIPA), and moderate-vigorous physical activity (MVPA) made up the composition. Outcomes included body mass index (BMI), waist circumference, HDL cholesterol, total:HDL cholesterol ratio, triglycerides, and glycated haemoglobin (HbA1c). Compositional linear regression examined associations between compositions and outcomes, including modelling time reallocation between behaviours. Results: The average daily composition of the sample (age: 53.7 ± 9.7 years; 54.7% female) was 7.7 h sleeping, 10.4 h sedentary, 3.1 h standing, 1.5 h LIPA, and 1.3 h MVPA. A greater MVPA proportion and smaller SB proportion were associated with better outcomes. Reallocating time from SB, standing, LIPA, or sleep into MVPA resulted in better scores across all outcomes. For example, replacing 30 min of SB, sleep, standing, or LIPA with MVPA was associated with −0.63 (95% confidence interval −0.48, −0.79), −0.43 (−0.25, −0.59), −0.40 (−0.25, −0.56), and −0.15 (0.05, −0.34) kg/m2 lower BMI, respectively. Greater relative standing time was beneficial, whereas sleep had a detrimental association when replacing LIPA/MVPA and positive association when replacing SB. The minimal displacement of any behaviour into MVPA for improved cardiometabolic health ranged from 3.8 (HbA1c) to 12.7 (triglycerides) min/day. Conclusions: Compositional data analyses reveal

Published
2023
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50. Long-term cardiovascular health status and physical functioning of nonhospitalized patients with COVID-19 compared with non-COVID-19 controls

Author

HAG Trombose, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, HAG Hart- Vaatziekten, van der Sluijs, Koen M, Bakker, Esmée A, Schuijt, Tim, Joseph, Jayaraj, Kavousi, Maryam, Geersing, Geert-Jan, Rutten, Frans H, Hartman, Yvonne A W, Thijssen, Dick H J, Eijsvogels, Thijs M H, HAG Trombose, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, HAG Hart- Vaatziekten, van der Sluijs, Koen M, Bakker, Esmée A, Schuijt, Tim, Joseph, Jayaraj, Kavousi, Maryam, Geersing, Geert-Jan, Rutten, Frans H, Hartman, Yvonne A W, Thijssen, Dick H J, and Eijsvogels, Thijs M H

Published
2023

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