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3. Impaired SARS-CoV-2 specific T-cell response in patients with severe COVID-19

Author

Rümke, Lidewij W., primary, Smit, Wouter L., additional, Bossink, Ailko, additional, Limonard, Gijs J. M., additional, Muilwijk, Danya, additional, Haas, Lenneke E. M., additional, Reusken, Chantal, additional, van der Wal, Sanne, additional, Thio, Bing J., additional, van Os, Yvonne M. G., additional, Gremmels, Hendrik, additional, Beekman, Jeffrey M., additional, Nijhuis, Monique, additional, Wensing, Annemarie M. J., additional, Heron, Michiel, additional, and Thijsen, Steven F. T., additional

Published
2023
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4. Seroprevalence and Risk Factors of Lyme Borreliosis in The Netherlands: A Population-Based Cross-Sectional Study

Author

Medische Microbiologie, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, Hoeve-Bakker, B J A, van den Berg, Oda E, Doppenberg, H S, van der Klis, Fiona R M, van den Wijngaard, Cees C, Kluytmans, Jan A J W, Thijsen, Steven F T, Kerkhof, Karen, Medische Microbiologie, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, Hoeve-Bakker, B J A, van den Berg, Oda E, Doppenberg, H S, van der Klis, Fiona R M, van den Wijngaard, Cees C, Kluytmans, Jan A J W, Thijsen, Steven F T, and Kerkhof, Karen

Published
2023

7. In-depth Characterization of Vaccine Breakthrough Infections With SARS-CoV-2 Among Health Care Workers in a Dutch Academic Medical Center

Author

MMB opleiding Arts microbioloog, Infection & Immunity, MMB Research line 3a, MMB Staf diagnostiek, MMB Medische Staf, CDL Patiëntenzorg MI, CTI Research, Cancer, Longziekten onderzoek 2, Onderzoek, Child Health, Regenerative Medicine and Stem Cells, Rümke, Lidewij W, Groenveld, Femke C, van Os, Yvonne M G, Praest, Patrique, Tanja, Anniek A N, de Jong, Dorien T C M, Symons, Jori, Schuurman, Rob, Reinders, Tessa, Hofstra, L Marije, Nierkens, Stefan, Thijsen, Steven F T, Heron, Michiel, Lebbink, Robert-Jan, Beekman, Jeffrey M, Nijhuis, Monique, Wensing, Annemarie M J, MMB opleiding Arts microbioloog, Infection & Immunity, MMB Research line 3a, MMB Staf diagnostiek, MMB Medische Staf, CDL Patiëntenzorg MI, CTI Research, Cancer, Longziekten onderzoek 2, Onderzoek, Child Health, Regenerative Medicine and Stem Cells, Rümke, Lidewij W, Groenveld, Femke C, van Os, Yvonne M G, Praest, Patrique, Tanja, Anniek A N, de Jong, Dorien T C M, Symons, Jori, Schuurman, Rob, Reinders, Tessa, Hofstra, L Marije, Nierkens, Stefan, Thijsen, Steven F T, Heron, Michiel, Lebbink, Robert-Jan, Beekman, Jeffrey M, Nijhuis, Monique, and Wensing, Annemarie M J

Published
2022

10. In depth characterization of vaccine breakthrough infections with SARS-CoV-2 among healthcare workers of a Dutch academic medical center

Author

Rümke, Lidewij W, primary, Groenveld, Femke C, additional, van Os, Yvonne M G, additional, Praest, Patrique, additional, Tanja, Anniek A N, additional, de Jong, Dorien T C M, additional, Symons, Jori, additional, Schuurman, Rob, additional, Reinders, Tessa, additional, Hofstra, L Marije, additional, Nierkens, Stefan, additional, Thijsen, Steven F T, additional, Heron, Michiel, additional, Lebbink, Robert-Jan, additional, Beekman, Jeffrey M, additional, Nijhuis, Monique, additional, and Wensing, Annemarie M J, additional

Published
2021
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11. Serum Biomarker Profile Including CCL1, CXCL10, VEGF, and Adenosine Deaminase Activity Distinguishes Active From Remotely Acquired Latent Tuberculosis

Author

Delemarre, Eveline M., primary, van Hoorn, Laura, additional, Bossink, Aik W. J., additional, Drylewicz, Julia, additional, Joosten, Simone A., additional, Ottenhoff, Tom H. M., additional, Akkerman, Onno W., additional, Goletti, Delia, additional, Petruccioli, Elisa, additional, Navarra, Assunta, additional, van den Broek, Brigitte T. A., additional, Paardekooper, Sanne P. A., additional, van Haeften, Ineke, additional, Koenderman, Leo, additional, Lammers, Jan-Willem J., additional, Thijsen, Steven F. T., additional, Hofland, Regina W., additional, and Nierkens, Stefan, additional

Published
2021
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12. The consequences of the edge-effect in a commercial enzyme-linked immunosorbent assay (ELISA) for the diagnosis of Lyme neuroborreliosis

Author

van Gorkom, Tamara, van Arkel, Gijs H J, Voet, Willem, Thijsen, Steven F T, and Kremer, Kristin

Abstract

The diagnosis of Lyme neuroborreliosis (LNB) is based on neurological symptoms, cerebrospinal fluid (CSF) pleocytosis, and intrathecally produced Borrelia-specific antibodies. In most cases, the presence of intrathecally produced Borrelia-specific antibodies is determined by using an enzyme-linked immunosorbent assay (ELISA). The edge-effect is a known phenomenon in ELISAs and can negatively influence the assay reproducibility, repeatability, as well as index calculations of sample pairs which are tested in the same run.

Published
2021

16. Serum Biomarker Profile Including CCL1, CXCL10, VEGF, and Adenosine Deaminase Activity Distinguishes Active From Remotely Acquired Latent Tuberculosis

Author

CTI Bont, Infection & Immunity, CTI UDAIR, CTI Computational Immunology Core, CTI Borghans, CTI Nierkens, Experimentele Afdeling Longziekten, Cancer, Dier Experimenten Commissie, Longziekten, CDL Patiëntenzorg MI, CTI Research, Delemarre, Eveline M, van Hoorn, Laura, Bossink, Aik W J, Drylewicz, Julia, Joosten, Simone A, Ottenhoff, Tom H M, Akkerman, Onno W, Goletti, Delia, Petruccioli, Elisa, Navarra, Assunta, van den Broek, Brigitte T A, Paardekooper, Sanne P A, van Haeften, Ineke, Koenderman, Leo, Lammers, Jan-Willem J, Thijsen, Steven F T, Hofland, Regina W, Nierkens, Stefan, CTI Bont, Infection & Immunity, CTI UDAIR, CTI Computational Immunology Core, CTI Borghans, CTI Nierkens, Experimentele Afdeling Longziekten, Cancer, Dier Experimenten Commissie, Longziekten, CDL Patiëntenzorg MI, CTI Research, Delemarre, Eveline M, van Hoorn, Laura, Bossink, Aik W J, Drylewicz, Julia, Joosten, Simone A, Ottenhoff, Tom H M, Akkerman, Onno W, Goletti, Delia, Petruccioli, Elisa, Navarra, Assunta, van den Broek, Brigitte T A, Paardekooper, Sanne P A, van Haeften, Ineke, Koenderman, Leo, Lammers, Jan-Willem J, Thijsen, Steven F T, Hofland, Regina W, and Nierkens, Stefan

Published
2021

17. Attributable mortality of antibiotic resistance in Gram-negative infections in the Netherlands: a parallel matched cohort study

Author

Epi Infectieziekten Team 1, Epidemiology & Health Economics, Epi Infectieziekten, MMB, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, Rottier, Wouter C, Deelen, J W Timotëus, Caruana, Giorgia, Buiting, Anton G M, Dorigo-Zetsma, J Wendelien, Kluytmans, Jan A J W, van der Linden, Paul D, Thijsen, Steven F T, Vlaminckx, Bart J M, Weersink, Annemarie J L, Ammerlaan, Heidi S M, Bonten, Marc J M, Epi Infectieziekten Team 1, Epidemiology & Health Economics, Epi Infectieziekten, MMB, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, Rottier, Wouter C, Deelen, J W Timotëus, Caruana, Giorgia, Buiting, Anton G M, Dorigo-Zetsma, J Wendelien, Kluytmans, Jan A J W, van der Linden, Paul D, Thijsen, Steven F T, Vlaminckx, Bart J M, Weersink, Annemarie J L, Ammerlaan, Heidi S M, and Bonten, Marc J M

Published
2021

18. Short-course aminoglycosides as adjunctive empirical therapy in patients with Gram-negative bloodstream infection, a cohort study

Author

JC onderzoeksprogramma Infectieziekten, Infection & Immunity, Epi Infectieziekten Team 1, MMB, Epidemiology & Health Economics, Epi Infectieziekten, Deelen, J W Timotëus, Rottier, Wouter C, Buiting, Anton G M, Dorigo-Zetsma, J Wendelien, Kluytmans, Jan A J W, van der Linden, Paul D, Thijsen, Steven F T, Vlaminckx, Bart J M, Weersink, Annemarie J L, Ammerlaan, Heidi S M, Bonten, Marc J M, van Werkhoven, Cornelis H, JC onderzoeksprogramma Infectieziekten, Infection & Immunity, Epi Infectieziekten Team 1, MMB, Epidemiology & Health Economics, Epi Infectieziekten, Deelen, J W Timotëus, Rottier, Wouter C, Buiting, Anton G M, Dorigo-Zetsma, J Wendelien, Kluytmans, Jan A J W, van der Linden, Paul D, Thijsen, Steven F T, Vlaminckx, Bart J M, Weersink, Annemarie J L, Ammerlaan, Heidi S M, Bonten, Marc J M, and van Werkhoven, Cornelis H

Published
2021

19. The burden of bacteremic and non-bacteremic Gram-negative infections: a prospective multicenter cohort study in a low-resistance country

Author

Epi Infectieziekten Team 1, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, MMB, MMB KAM, Epi Infectieziekten, Deelen, J W Timotëus, Rottier, Wouter C, van Werkhoven, Cornelis H, Woudt, Sjoukje H S, Buiting, Anton G M, Dorigo-Zetsma, J Wendelien, Kluytmans, Jan A J W, van der Linden, Paul D, Thijsen, Steven F T, Vlaminckx, Bart J M, Weersink, Annemarie J L, Ammerlaan, Heidi S M, Bonten, Marc J M, Epi Infectieziekten Team 1, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, MMB, MMB KAM, Epi Infectieziekten, Deelen, J W Timotëus, Rottier, Wouter C, van Werkhoven, Cornelis H, Woudt, Sjoukje H S, Buiting, Anton G M, Dorigo-Zetsma, J Wendelien, Kluytmans, Jan A J W, van der Linden, Paul D, Thijsen, Steven F T, Vlaminckx, Bart J M, Weersink, Annemarie J L, Ammerlaan, Heidi S M, and Bonten, Marc J M

Published
2020

22. Ecological Effects of Selective Decontamination on Resistant Gram-negative Bacterial Colonization

Author

Oostdijk, Evelien A. N., de Smet, Anne Marie G. A., Blok, Hetty E. M., Thieme Groen, Emily S., van Asselt, Gerard J., Benus, Robin F. J., Bernards, Sandra A. T., Frénay, Ine H. M. E., Jansz, Arjan R., de Jongh, Bartelt M., Kaan, Jan A., Leverstein-van Hall, Maurine A., Mascini, Ellen M., Pauw, Wouter, Sturm, Patrick D. J., Thijsen, Steven F. T., Kluytmans, Jan A. J. W., and Bonten, Marc J. M.

Published
2010
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23. In-depth Characterization of Vaccine Breakthrough Infections With SARS-CoV-2 Among Health Care Workers in a Dutch Academic Medical Center.

Author

Rümke, Lidewij W, Groenveld, Femke C, Os, Yvonne M G van, Praest, Patrique, Tanja, Anniek A N, Jong, Dorien T C M de, Symons, Jori, Schuurman, Rob, Reinders, Tessa, Hofstra, L Marije, Nierkens, Stefan, Thijsen, Steven F T, Heron, Michiel, Lebbink, Robert-Jan, Beekman, Jeffrey M, Nijhuis, Monique, and Wensing, Annemarie M J

Abstract

Severe acute respiratory syndrome coronavirus 2 infection after coronavirus disease 2019 vaccination raises concerns about the emergence of vaccine escape variants. Here we characterize 14 breakthrough infections among 5860 fully vaccinated Dutch health care workers ≥14 days after the final dose of vaccination with either BNT162b2, mRNA-1273, or Ad26.COV2.S. These breakthrough infections presented with regular B.1.1.7 (Alpha) and B.1.617.2 (Delta) variants and high viral loads, despite normal vaccine-induced B- and T-cell immune responses detected by live virus neutralization assays and ELISpot. High-risk exposure settings, such as in households, indicate a potential risk of viral transmission despite full vaccination. [ABSTRACT FROM AUTHOR]

Published
2022
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24. CD1b presents self and Borrelia burgdorferi diacylglycerols to human T cells

Author

Reinink, Peter, Souter, Michael N T, Cheng, Tan-Yun, van Gorkom, Tamara, Lenz, Stefanie, Kubler-Kielb, Joanna, Strle, Klemen, Kremer, Kristin, Thijsen, Steven F T, Steere, Allen C, Godfrey, Dale I, Pellicci, Daniel G, Moody, D Branch, Van Rhijn, Ildiko, LS Immunologie, and dI&I RA-I&I I&I

Subjects
lipid antigen, T cells, Lyme disease, antigen specificity, CD1b
Abstract

Lyme disease is a common multi-system disease caused by infection with a tick-transmitted spirochete, Borrelia burgdorferi and related Borrelia species. The monoglycosylated diacylglycerol known as B. burgdorferi glycolipid II (BbGL-II) is a major target of antibodies in sera from infected individuals. Here we show that CD1b presents BbGL-II to human T cells and that the T cell receptor (TCR) mediates the recognition. However, we did not detect increased frequency of CD1b-BbGL-II binding T cells in the peripheral blood of Lyme disease patients compared to controls. Unexpectedly, mapping the T cell specificity for BbGL-II-like molecules using tetramers and activation assays revealed a concomitant response to CD1b-expressing antigen presenting cells in absence of BbGL-II. Further, among all major classes of self-lipid tested, BbGL-II responsive TCRs show strong cross-reactivity to diacylglycerol, a self-lipid antigen with structural similarities to BbGL-II. Extending prior work on MHC and CD1b, CD1c, and CD1d proteins, this study provides evidence for cross-reactive CD1b-restricted T cell responses to bacterial and self-antigens, and identifies chemically defined targets for future discovery of self and foreign antigen cross-reactive T cells. This article is protected by copyright. All rights reserved.

Published
2019

26. Development of diagnostic prediction tools for bacteraemia caused by 3rd generation cephalosporin-resistant Enterobacteriaceae in suspected bacterial infections: a nested case-control study

Author

Rottier, Wouter C, van Werkhoven, Cornelis H., Bamberg, Yara R P, Dorigo-Zetsma, J Wendelien, van de Garde, Ewoudt M, van Hees, Babette C, Kluytmans, Jan A J W, Kuck, Emile M, Van Der Linden, Paul D., Prins, Jan M., Thijsen, Steven F T, Verbon, Annelies, Vlaminckx, Bart J.M., Ammerlaan, Heidi S M, Bonten, Marc J M, Afd Pharmacoepi & Clinical Pharmacology, and Pharmacoepidemiology and Clinical Pharmacology

Subjects
Risk factors, Enterobacteria, Clinical prediction models, Taverne, Scoring systems, Extended-spectrum β-lactamases, Empirical antibiotic therapy
Abstract

OBJECTIVES: Current guidelines for empiric antibiotic treatment poorly predict the presence of 3rd generation cephalosporin-resistant Enterobacteriaceae bacteraemia (3GCR-E-Bac) as a cause of infection, thereby increasing unnecessary carbapenem use. We aimed to develop diagnostic scoring systems to better predict the presence of 3GCR-E-Bac. METHODS: A retrospective nested case-control study was performed that included patients ≥18 years from eight Dutch hospitals in whom blood cultures were obtained and intravenous antibiotics were initiated. Each patient with 3GCR-E-Bac was matched to four control infection episodes within the same hospital, based on blood culture date and onset location (community or hospital). Starting from 32 commonly described clinical risk factors available at infection onset, selection strategies were used to derive scoring systems for the probability of community- and hospital-onset 3GCR-E-Bac. RESULTS: 3GCR-E-Bac occurred in 90 of 22,506 (0.4%) community-onset and in 82 of 8,110 (1.0%) hospital-onset infections, and these cases were matched to 360 community-onset and 328 hospital-onset control episodes. The derived community-onset and hospital-onset scoring systems consisted of 6 and 9 predictors, respectively. With selected score cutoffs, the models identified 3GCR-E-Bac with equal sensitivity as existing guidelines (community-onset: 54.3%; hospital-onset: 81.5%). Yet, they reduced the proportion of patients classified as at risk for 3GCR-E-Bac (i.e. eligible for empiric carbapenem therapy) with 40% (95% confidence interval 21-56%) and 49% (95% confidence interval 39-58%) in, respectively, community-onset and hospital-onset infection. CONCLUSIONS: These prediction scores for 3GCR-E-Bac, specifically geared towards the initiation of empiric antibiotic treatment, may improve the balance between inappropriate antibiotics and carbapenem overuse.

Published
2018

27. Molecular quantification of viral load in plasma allows for fast and accurate prediction of response to therapy of Epstein–Barr virus-associated lymphoproliferative disease after allogeneic stem cell transplantation

Author

van Esser, Joost W. J., Niesters, Hubert G. M., Thijsen, Steven F. T., Meijer, Ellen, Osterhaus, Albert D. M. E., Wolthers, Katja C., Boucher, Charles A. B., Gratama, Jan Willem, Budel, Leo M., van der Holt, Bronno, van Loon, Anton M., Löwenberg, Bob, Verdonck, Leo F., and Cornelissen, Jan J.

Published
2001

29. Development of diagnostic prediction tools for bacteraemia caused by 3rd generation cephalosporin-resistant Enterobacteriaceae in suspected bacterial infections: a nested case-control study

Author

Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology, Rottier, Wouter C, van Werkhoven, Cornelis H., Bamberg, Yara R P, Dorigo-Zetsma, J Wendelien, van de Garde, Ewoudt M, van Hees, Babette C, Kluytmans, Jan A J W, Kuck, Emile M, Van Der Linden, Paul D., Prins, Jan M., Thijsen, Steven F T, Verbon, Annelies, Vlaminckx, Bart J.M., Ammerlaan, Heidi S M, Bonten, Marc J M, Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology, Rottier, Wouter C, van Werkhoven, Cornelis H., Bamberg, Yara R P, Dorigo-Zetsma, J Wendelien, van de Garde, Ewoudt M, van Hees, Babette C, Kluytmans, Jan A J W, Kuck, Emile M, Van Der Linden, Paul D., Prins, Jan M., Thijsen, Steven F T, Verbon, Annelies, Vlaminckx, Bart J.M., Ammerlaan, Heidi S M, and Bonten, Marc J M

Published
2018

30. Clinical Aspects of Immune Responses in Tuberculosis

Author

Longziekten, Lammers, Jan-Willem J., Bossink, Ailko W J, Thijsen, Steven F T, Hofland, R.W., Longziekten, Lammers, Jan-Willem J., Bossink, Ailko W J, Thijsen, Steven F T, and Hofland, R.W.

Published
2018

31. Quantifying within-household transmission of ESBL-producing bacteria

Author

Haverkate, Manon R, Platteel, Tamara N, Fluit, A C, Cohen Stuart, James W, Leverstein-van Hall, Maurine A, Thijsen, Steven F T, Scharringa, J., Kloosterman, Fieke R C, Bonten, Marc J M, and Bootsma, Martin C J

Subjects
Mathematical model, Enterobacteriaceae, Journal Article, Colonisation, Within-household transmission, Extended-spectrum beta-lactamase (ESBL)
Abstract

OBJECTIVES: Patients can acquire extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae during hospitalisation and colonised patients may transmit these bacteria after discharge, most likely to household contacts. In this study, ESBL transmission was quantified in households. METHODS: Fecal samples were longitudinally collected from hospitalised patients colonised with ESBL-producing bacteria and from their household members during hospitalisation of the index patient and at 3, 6, 12, and 18 months. A mathematical household model was developed which allowed for person-to-person transmission, acquisition from other sources (background transmission), and losing carriage. Next, a deterministic population model with a household structure was created, informed by parameter values found in the household model. RESULTS: 74 index patients and 84 household members were included. In more than half of the household members ESBL-producing bacteria were demonstrated at some time during follow up. Person-to-person transmission occurred at a rate of 0.0053/colonised person/day (0.0025-0.011), background transmission at 0.00015/day (95% CI 0.00002-0.00039), and decolonization at 0.0026/day (0.0016-0.0040) for index patients and 0.0090/day (0.0046-0.018) for household members. The estimated probability of transmission from an index patient to a household contact was 67% and 37% vice versa. CONCLUSION: There is frequent transmission of ESBL-producing bacteria in households, which may contribute to the observed endemicity of ESBL carriage in the Netherlands. However, the population model suggests that there is not a single dominant acquisition route in the community.

Published
2017

33. REtrieval And cure of Chronic Hepatitis C (REACH): Results of micro-elimination in the Utrecht province

Author

Kracht, Patricia A. M., primary, Arends, Joop E., additional, van Erpecum, Karel J., additional, Thijsen, Steven F. T., additional, Vlaminckx, Bart J. M., additional, Weersink, Annemarie J. L., additional, Wensing, Anne M. J., additional, Deege, Marjolein P. H., additional, Dimmendaal, Marieke, additional, Stadhouders, Paul H. G. M., additional, Friederich, Philip W., additional, Verhagen, Marc A. M. T., additional, Boland, Greet J., additional, and Hoepelman, Andy I. M., additional

Published
2018
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36. Positive predictive value of ELISpot in BAL and pleural fluid from patients with suspected pulmonary tuberculosis

Author

Longziekten, Infection & Immunity, Biostatistiek Onderzoek, Circulatory Health, Directie Kwaliteit v. Zorg en Patiëntv., Hofland, Regina W., Thijsen, Steven F T, van Lindert, Anne S R, de Lange, Wiel C M, van Gorkom, Tamara, van der Tweel, Ingeborg, Lammers, Jan Willem J, Bossink, Aik W J, Longziekten, Infection & Immunity, Biostatistiek Onderzoek, Circulatory Health, Directie Kwaliteit v. Zorg en Patiëntv., Hofland, Regina W., Thijsen, Steven F T, van Lindert, Anne S R, de Lange, Wiel C M, van Gorkom, Tamara, van der Tweel, Ingeborg, Lammers, Jan Willem J, and Bossink, Aik W J

Published
2017

37. Quantifying within-household transmission of ESBL-producing bacteria

Author

Epi Infectieziekten Team 1, MMB, MMB Research line 2, Infection & Immunity, Epi Infectieziekten, JC onderzoeksprogramma Infectieziekten, Haverkate, Manon R, Platteel, Tamara N, Fluit, A C, Cohen Stuart, James W, Leverstein-van Hall, Maurine A, Thijsen, Steven F T, Scharringa, J., Kloosterman, Fieke R C, Bonten, Marc J M, Bootsma, Martin C J, Epi Infectieziekten Team 1, MMB, MMB Research line 2, Infection & Immunity, Epi Infectieziekten, JC onderzoeksprogramma Infectieziekten, Haverkate, Manon R, Platteel, Tamara N, Fluit, A C, Cohen Stuart, James W, Leverstein-van Hall, Maurine A, Thijsen, Steven F T, Scharringa, J., Kloosterman, Fieke R C, Bonten, Marc J M, and Bootsma, Martin C J

Published
2017

40. REtrieval And cure of Chronic Hepatitis C (REACH): Results of micro‐elimination in the Utrecht province.

Author

Kracht, Patricia A. M., Arends, Joop E., van Erpecum, Karel J., Wensing, Anne M. J., Boland, Greet J., Hoepelman, Andy I. M., Thijsen, Steven F. T., Verhagen, Marc A. M. T., Vlaminckx, Bart J. M., Stadhouders, Paul H. G. M., Weersink, Annemarie J. L., Friederich, Philip W., Deege, Marjolein P. H., and Dimmendaal, Marieke

Subjects
DIAGNOSTIC services, NEEDLE exchange programs, HEPATITIS C, CHRONIC hepatitis C, HEPATITIS C virus
Abstract

Background: The Netherlands is one of the six European countries considered on track to eliminate hepatitis C virus by 2030. To achieve this goal, continuous efforts have to be put into designing efficient case‐finding strategies, including the retrieval of previously diagnosed hepatitis C virus‐infected who are lost to follow‐up. Aims: To trace and treat all lost to follow‐up hepatitis C virus patients in the Utrecht region and create an efficient retrieval strategy that can be used in future (national) retrieval initiatives. Methods: Positive hepatitis C virus diagnostic tests (anti‐hepatitis C virus IgG or hepatitis C virus‐RNA) from the laboratory of all four hospitals and one central laboratory for primary care diagnostics in the province of Utrecht from 2001 to 2015 were linked to clinical records. Untreated patients with available contact information were deemed eligible for retrieval and invited for reevaluation with (virology) blood tests, fibroscan measurement and possible direct‐acting antiviral therapy. Main results: After screening all hepatitis C virus diagnostics, 1913 chronic hepatitis C virus‐infected were identified of which 14.1% (n = 269) were invited back into care. Overall, 17.4% was traced with the highest yield (28.3%) in those who lived in the Utrecht province. Through renewed patient assessments, 42 chronic hepatitis C virus infections were re‐identified (76% with a history of intravenous drug use, 24% with Metavir F3‐F4). Until now, 59% has either scheduled or initiated direct‐acting antiviral therapy. Conclusion: The retrieval of previously diagnosed hepatitis C virus patients through screening of laboratory diagnostics from the past is feasible and should be pursued for further control and reduction of hepatitis C virus infection. Retrieval is most successful when performed regionally. Lay summary: To completely eliminate chronic hepatitis C virus (HCV) infection and prevent complications, undiagnosed and also previously diagnosed but lost to follow‐up (LFU) HCV patients have to be brought (back) into care for therapy. Retrieval of LFU HCV patients through screening of laboratory diagnostics from the past is feasible and most successful when performed regionally. [ABSTRACT FROM AUTHOR]

Published
2019
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44. Antibiotic Treatment Strategies for Community-Acquired Pneumonia in Adults

Author

Postma, Douwe F., Van Werkhoven, Cornelis H., Van Elden, Leontine J R, Thijsen, Steven F T, Hoepelman, Andy I M, Kluytmans, Jan A J W, Boersma, Wim G., Compaijen, Clara J., Van Der Wall, Eva, Prins, Jan M., Oosterheert, Jan J., Bonten, Marc J M, Postma, Douwe F., Van Werkhoven, Cornelis H., Van Elden, Leontine J R, Thijsen, Steven F T, Hoepelman, Andy I M, Kluytmans, Jan A J W, Boersma, Wim G., Compaijen, Clara J., Van Der Wall, Eva, Prins, Jan M., Oosterheert, Jan J., and Bonten, Marc J M

Published
2015

45. Antibiotic Treatment Strategies for Community-Acquired Pneumonia in Adults

Author

Epi Infectieziekten Team 1, JC onderzoeksprogramma Infectieziekten, Infection & Immunity, MS Infectieziekten, Epi Infectieziekten, MMB, Postma, Douwe F., Van Werkhoven, Cornelis H., Van Elden, Leontine J R, Thijsen, Steven F T, Hoepelman, Andy I M, Kluytmans, Jan A J W, Boersma, Wim G., Compaijen, Clara J., Van Der Wall, Eva, Prins, Jan M., Oosterheert, Jan J., Bonten, Marc J M, Epi Infectieziekten Team 1, JC onderzoeksprogramma Infectieziekten, Infection & Immunity, MS Infectieziekten, Epi Infectieziekten, MMB, Postma, Douwe F., Van Werkhoven, Cornelis H., Van Elden, Leontine J R, Thijsen, Steven F T, Hoepelman, Andy I M, Kluytmans, Jan A J W, Boersma, Wim G., Compaijen, Clara J., Van Der Wall, Eva, Prins, Jan M., Oosterheert, Jan J., and Bonten, Marc J M

Published
2015

49. Appropriateness of Empirical Treatment and Outcome in Bacteremia Caused by Extended-Spectrum-β-Lactamase-Producing Bacteria

Author

Frakking, Florine N. J., primary, Rottier, Wouter C., additional, Dorigo-Zetsma, J. Wendelien, additional, van Hattem, Jarne M., additional, van Hees, Babette C., additional, Kluytmans, Jan A. J. W., additional, Lutgens, Suzanne P. M., additional, Prins, Jan M., additional, Thijsen, Steven F. T., additional, Verbon, Annelies, additional, Vlaminckx, Bart J. M., additional, Cohen Stuart, James W., additional, Leverstein-van Hall, Maurine A., additional, and Bonten, Marc J. M., additional

Published
2013
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50. Clinical relevance of Corynebacterium pseudodiphtheriticum in lower respiratory tract specimens.

Author

Van Roeden, Sonja E., Thijsen, Steven F., Sankatsing, Sanjay U.C., and Limonard, Gijs J.M.

Subjects
*ACADEMIC medical centers, *AMOXICILLIN, *CELL culture, *CORYNEBACTERIUM, *MICROBIAL sensitivity tests, *CORYNEBACTERIUM diseases, *RESPIRATORY infections, *SECONDARY analysis, *RETROSPECTIVE studies, *DESCRIPTIVE statistics, *SYMPTOMS, *DISEASE risk factors, *DIAGNOSIS, RESPIRATORY organ microbiology
Abstract

Background: Corynebacterium pseudodiphtheriticummay be present as commensal flora of the respiratory tract and therefore it may be difficult to assess clinical relevance when it is cultured from lower respiratory tract specimens. Our objective was to determine the clinical relevance ofC. pseudodiphtheriticumas a lower respiratory tract pathogen and to define patients at risk of developing lower respiratory tract infections caused byC. pseudodiphtheriticum. Methods:We retrospectively identified all lower respiratory tract cultures positive forC. pseudodiphtheriticumover a 10-year period and assessed clinical relevance by predefined criteria.Results:Clinical relevance was likely or possible in 86% of patients. Pre-existent comorbidity was present in 86% of patients, mostly underlying cardiac or pulmonary disease. All isolates were susceptible to amoxicillin.Conclusion: C. pseudodiphtheriticumshould be considered a clinically relevant pathogen when cultured from the lower respiratory tract in symptomatic patients. [ABSTRACT FROM AUTHOR]

Published
2015
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